NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446343393|ref|WP_000421248|]
View 

type II toxin-antitoxin system RelE/ParE family toxin [Escherichia coli]

Protein Classification

type II toxin-antitoxin system RelE/ParE family toxin( domain architecture ID 10007814)

type II toxin-antitoxin (TA) system RelE/ParE family toxin is the RelE/ParE-like toxin component of a type II toxin-antitoxin system, its activity is attenuated by interaction with its cognate antitoxin

Gene Ontology:  GO:0110001|GO:0090729
PubMed:  20143871|20487277|28279904|15718296

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
1-90 5.24e-18

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


:

Pssm-ID: 442885  Cd Length: 96  Bit Score: 71.46  E-value: 5.24e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446343393  1 MELKWSSKALSDLARLYDFLVL-ASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTI 79
Cdd:COG3668   1 MKVRWTPEAEADLEEIYDYIAEdWGPEAAERYLDEIEEAIELLAEFPELGRPRPELRVPGLRELVVGPYVIFYRVDDDTV 80

                        90
                ....*....|.
gi 446343393 80 YVLRLWHTREN 90
Cdd:COG3668  81 EILRVLHGRRD 91
 
Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
1-90 5.24e-18

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


Pssm-ID: 442885  Cd Length: 96  Bit Score: 71.46  E-value: 5.24e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446343393  1 MELKWSSKALSDLARLYDFLVL-ASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTI 79
Cdd:COG3668   1 MKVRWTPEAEADLEEIYDYIAEdWGPEAAERYLDEIEEAIELLAEFPELGRPRPELRVPGLRELVVGPYVIFYRVDDDTV 80

                        90
                ....*....|.
gi 446343393 80 YVLRLWHTREN 90
Cdd:COG3668  81 EILRVLHGRRD 91
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 3-90 4.65e-16

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 66.68  E-value: 4.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446343393   3 LKWSSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEL--NGQTIY 80
Cdd:pfam05016  1 VILTPKALKDLKKIADYIAQDNPDAAERFLKALEEALELLAENPALGRPLPEGGLKGLRRIRIGDYRIIYRIddDDLVIL 80

                         90
                 ....*....|
gi 446343393  81 VLRLWHTREN 90
Cdd:pfam05016 81 ILRVGHRRRD 90
 
Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
1-90 5.24e-18

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


Pssm-ID: 442885  Cd Length: 96  Bit Score: 71.46  E-value: 5.24e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446343393  1 MELKWSSKALSDLARLYDFLVL-ASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTI 79
Cdd:COG3668   1 MKVRWTPEAEADLEEIYDYIAEdWGPEAAERYLDEIEEAIELLAEFPELGRPRPELRVPGLRELVVGPYVIFYRVDDDTV 80

                        90
                ....*....|.
gi 446343393 80 YVLRLWHTREN 90
Cdd:COG3668  81 EILRVLHGRRD 91
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 3-90 4.65e-16

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 66.68  E-value: 4.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446343393   3 LKWSSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEL--NGQTIY 80
Cdd:pfam05016  1 VILTPKALKDLKKIADYIAQDNPDAAERFLKALEEALELLAENPALGRPLPEGGLKGLRRIRIGDYRIIYRIddDDLVIL 80

                         90
                 ....*....|
gi 446343393  81 VLRLWHTREN 90
Cdd:pfam05016 81 ILRVGHRRRD 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH