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Conserved domains on  [gi|446344840|ref|WP_000422695|]
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MULTISPECIES: IS66-like element accessory protein TnpA [Escherichia]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IS66_access_TnpA super family cl45815
IS66-like element accessory protein TnpA;
6-122 6.73e-24

IS66-like element accessory protein TnpA;


The actual alignment was detected with superfamily member NF038385:

Pssm-ID: 439678 [Multi-domain]  Cd Length: 190  Bit Score: 91.31  E-value: 6.73e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446344840   6 WRKEPRKKYSNEFKLRMVELASQPGACVAQIARENGVNDNVIFKWLRLWQNEGrisrrlpVTTTSDAGLELLPVEITSD- 84
Cdd:NF038385  81 WKKIRRPNFSREFKIRLVEQTLQPGACVAQIARENGINDNLLFNWRHLYRNGL-------LQPDNEQETALLPVTLTPEp 153

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446344840  85 EPKEPMAALIPPLsTQTTVSASSCKVEFRHGNMTLENP 122
Cdd:NF038385 154 DPTIPVPAQDPEQ-QNTTADSLCCELVLPAGTLRLFGP 190
 
Name Accession Description Interval E-value
IS66_access_TnpA NF038385
IS66-like element accessory protein TnpA;
6-122 6.73e-24

IS66-like element accessory protein TnpA;


Pssm-ID: 439678 [Multi-domain]  Cd Length: 190  Bit Score: 91.31  E-value: 6.73e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446344840   6 WRKEPRKKYSNEFKLRMVELASQPGACVAQIARENGVNDNVIFKWLRLWQNEGrisrrlpVTTTSDAGLELLPVEITSD- 84
Cdd:NF038385  81 WKKIRRPNFSREFKIRLVEQTLQPGACVAQIARENGINDNLLFNWRHLYRNGL-------LQPDNEQETALLPVTLTPEp 153

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446344840  85 EPKEPMAALIPPLsTQTTVSASSCKVEFRHGNMTLENP 122
Cdd:NF038385 154 DPTIPVPAQDPEQ-QNTTADSLCCELVLPAGTLRLFGP 190
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
8-72 5.00e-15

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 65.72  E-value: 5.00e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446344840   8 KEPRKKYSNEFKLRMVELASQPGACVAQIARENGVNDNVIFKWLRLWQNEGRISRRLPVTTTSDA 72
Cdd:COG2963    2 SKKRRRYSPEFKAEAVRLVLEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFPGDGRTTPEQ 66
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 8-55 3.00e-10

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 52.74  E-value: 3.00e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 446344840    8 KEPRKKYSNEFKLRMVELASQPGACVAQIARENGVNDNVIFKWLRLWQ 55
Cdd:pfam01527   1 MKKRRRFSEEFKLRAVKEVLEPGRTVKEVARRHGVSPNTLYQWRRQYE 48
transpos_IS3 NF033516
IS3 family transposase;
17-58 3.30e-07

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 47.95  E-value: 3.30e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 446344840  17 EFKLRMVELASQPGACVAQIARENGVNDNVIFKWLRLWQNEG 58
Cdd:NF033516   1 EFKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGGG 42
PRK09413 PRK09413
IS2 repressor TnpA; Reviewed
 9-61 4.07e-03

IS2 repressor TnpA; Reviewed


Pssm-ID: 181833  Cd Length: 121  Bit Score: 35.16  E-value: 4.07e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446344840   9 EPRKKYSNEFKLRMVELASQPGACVAQIARENGVNDNVIFKWLRLWQnEGRIS 61
Cdd:PRK09413   8 EKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQ-EGSLT 59
 
Name Accession Description Interval E-value
IS66_access_TnpA NF038385
IS66-like element accessory protein TnpA;
6-122 6.73e-24

IS66-like element accessory protein TnpA;


Pssm-ID: 439678 [Multi-domain]  Cd Length: 190  Bit Score: 91.31  E-value: 6.73e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446344840   6 WRKEPRKKYSNEFKLRMVELASQPGACVAQIARENGVNDNVIFKWLRLWQNEGrisrrlpVTTTSDAGLELLPVEITSD- 84
Cdd:NF038385  81 WKKIRRPNFSREFKIRLVEQTLQPGACVAQIARENGINDNLLFNWRHLYRNGL-------LQPDNEQETALLPVTLTPEp 153

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446344840  85 EPKEPMAALIPPLsTQTTVSASSCKVEFRHGNMTLENP 122
Cdd:NF038385 154 DPTIPVPAQDPEQ-QNTTADSLCCELVLPAGTLRLFGP 190
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
8-72 5.00e-15

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 65.72  E-value: 5.00e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446344840   8 KEPRKKYSNEFKLRMVELASQPGACVAQIARENGVNDNVIFKWLRLWQNEGRISRRLPVTTTSDA 72
Cdd:COG2963    2 SKKRRRYSPEFKAEAVRLVLEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFPGDGRTTPEQ 66
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 8-55 3.00e-10

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 52.74  E-value: 3.00e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 446344840    8 KEPRKKYSNEFKLRMVELASQPGACVAQIARENGVNDNVIFKWLRLWQ 55
Cdd:pfam01527   1 MKKRRRFSEEFKLRAVKEVLEPGRTVKEVARRHGVSPNTLYQWRRQYE 48
transpos_IS3 NF033516
IS3 family transposase;
17-58 3.30e-07

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 47.95  E-value: 3.30e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 446344840  17 EFKLRMVELASQPGACVAQIARENGVNDNVIFKWLRLWQNEG 58
Cdd:NF033516   1 EFKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGGG 42
HTH_23 pfam13384
Homeodomain-like domain;
19-58 3.09e-03

Homeodomain-like domain;


Pssm-ID: 433164 [Multi-domain]  Cd Length: 50  Bit Score: 33.78  E-value: 3.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 446344840   19 KLRMVELASQpGACVAQIARENGVNDNVIFKWLRLWQNEG 58
Cdd:pfam13384   7 RARALLLLAE-GLSVKEIAELLGVSRRTVYRWLKRYNEEG 45
PRK09413 PRK09413
IS2 repressor TnpA; Reviewed
 9-61 4.07e-03

IS2 repressor TnpA; Reviewed


Pssm-ID: 181833  Cd Length: 121  Bit Score: 35.16  E-value: 4.07e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446344840   9 EPRKKYSNEFKLRMVELASQPGACVAQIARENGVNDNVIFKWLRLWQnEGRIS 61
Cdd:PRK09413   8 EKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQ-EGSLT 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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