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Conserved domains on  [gi|446347231|ref|WP_000425086|]
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MULTISPECIES: BA2291 family sporulation histidine kinase [Bacillus]

Protein Classification

sensor histidine kinase( domain architecture ID 12099919)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KinD super family cl47427
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...
 31-375 1.51e-59

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5808:

Pssm-ID: 444510 [Multi-domain]  Cd Length: 454  Bit Score: 199.20  E-value: 1.51e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231  31 VENWKNKMIISEKDPFKLEVVQNGEDLLELIIELTMedkdinylQPLCEKIAIERAGADANIGDfVYNANVGRNELFEAM 110
Cdd:COG5808  132 MDYIRALINILDPDKYIEIVDQNGQSVFTSGHREES--------KSVSNKLDKVPWEVEVYPNP-VTNDELGQALAIRKL 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 111 CEldvsarelkpimakihtCFDKLIYYTVLKYSEIisKNLEEKQQYINETHKERLTILGQMSASFVHEFRNPLTSIMGFV 190
Cdd:COG5808  203 II-----------------LVLISIIFLLLQYNLL--KRKTLLERVIQEINTQKLELIGTFAASTAHEIRNPLTSIKGFI 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 191 KLLKADHPSL---SYLDIISHELDQLNFRISQFLLVSKKEMwNESERFWLNDLFQDIIQFLYPSLVNANVLIEKNLP-YP 266
Cdd:COG5808  264 QLLQEKYPELedqKYFDIIQEEIQRINQIVSEFLVLGKPTA-KKLELDDLNELIEEILSIIDSEANLKNIRVEKQSLdEP 342

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 267 IPLVGYRSEVRQVFLNILMNsidALESMKEERKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFVTTKKLGTGIGL 346
Cdd:COG5808  343 LHIKCDKDRIKQVLLNLIKN---AIEAMKEGGKLTISIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGL 419

                        330       340       350
                 ....*....|....*....|....*....|
gi 446347231 347 FVCKQIVEKHNGSIMCRSDND-WTEFQIAF 375
Cdd:COG5808  420 SVCKRIVEMHGGEIDIESEEGkGTTFTIRL 449
 
Name Accession Description Interval E-value
KinD COG5808
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...
 31-375 1.51e-59

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444510 [Multi-domain]  Cd Length: 454  Bit Score: 199.20  E-value: 1.51e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231  31 VENWKNKMIISEKDPFKLEVVQNGEDLLELIIELTMedkdinylQPLCEKIAIERAGADANIGDfVYNANVGRNELFEAM 110
Cdd:COG5808  132 MDYIRALINILDPDKYIEIVDQNGQSVFTSGHREES--------KSVSNKLDKVPWEVEVYPNP-VTNDELGQALAIRKL 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 111 CEldvsarelkpimakihtCFDKLIYYTVLKYSEIisKNLEEKQQYINETHKERLTILGQMSASFVHEFRNPLTSIMGFV 190
Cdd:COG5808  203 II-----------------LVLISIIFLLLQYNLL--KRKTLLERVIQEINTQKLELIGTFAASTAHEIRNPLTSIKGFI 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 191 KLLKADHPSL---SYLDIISHELDQLNFRISQFLLVSKKEMwNESERFWLNDLFQDIIQFLYPSLVNANVLIEKNLP-YP 266
Cdd:COG5808  264 QLLQEKYPELedqKYFDIIQEEIQRINQIVSEFLVLGKPTA-KKLELDDLNELIEEILSIIDSEANLKNIRVEKQSLdEP 342

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 267 IPLVGYRSEVRQVFLNILMNsidALESMKEERKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFVTTKKLGTGIGL 346
Cdd:COG5808  343 LHIKCDKDRIKQVLLNLIKN---AIEAMKEGGKLTISIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGL 419

                        330       340       350
                 ....*....|....*....|....*....|
gi 446347231 347 FVCKQIVEKHNGSIMCRSDND-WTEFQIAF 375
Cdd:COG5808  420 SVCKRIVEMHGGEIDIESEEGkGTTFTIRL 449
HisK_N pfam09385
Histidine kinase N terminal; This domain is found at the N terminal of sensor histidine kinase ...
 16-144 5.30e-57

Histidine kinase N terminal; This domain is found at the N terminal of sensor histidine kinase proteins.


Pssm-ID: 286473  Cd Length: 129  Bit Score: 182.11  E-value: 5.30e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231   16 KEIFCSHLKNNRHQFVENWKNKMIISEKDPFKLEVVQNGEDLLELIIELTMEDKDINYLQPLCEKIAIERAGADANIGDF 95
Cdd:pfam09385   1 KQVLVDYLEEHQPNFLSEWKKRILISDDDPYKDEIKQNGEALFSLVIEYLRESISLEDLERLAEKIAKERAEANVNIGDF 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 446347231   96 VYNANVGRNELFEAMCELDVSARELKPIMAKIHTCFDKLIYYTVLKYSE 144
Cdd:pfam09385  81 VYNVNVGRSEVINYLFKLNVPWDELQPIIDKINECFDKFLYYAVSKYTE 129
GS_BA2291-HK-like cd14755
Non-heme globin sensor domain of BA2291 histidine kinase and related domains; This subfamily ...
 15-146 1.66e-55

Non-heme globin sensor domain of BA2291 histidine kinase and related domains; This subfamily includes the sensor domain of Bacillus anthracis BA2291 histidine kinase. BA2291 is one of the most active kinases in promoting sporulation, and is found in most members of the Bacillus cereus subfamily of the genus Bacillus, which includes B. anthracis and Bacillus thuringiensis, but not Bacillus subtilis. This subfamily also includes two sensor-only plasmid encoded sporulation inhibitors pXO1-118 and pXO2-61 found only in B. anthracis and various strains of Bacillus cereus having similar plasmids. The pXO1-118 and pXO2-61 sensor domains form homodimers, and in vitro bind fatty acid and halide, and not heme; there may be roles for fatty acid (or similar molecule), chloride ion, and possibly pH, as signaling cues. It has been proposed that BA2291 senses the same environmental cue in vivo, and that pXO1-118 and pXO2-61 act by titrating out an environmental signal that might cause an ill-timed sporulation.


Pssm-ID: 271288  Cd Length: 132  Bit Score: 178.58  E-value: 1.66e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231  15 IKEIFCSHLKNNRHQFVENWKNKMIISEKDPFKLEVVQNGEDLLELIIELTMEDKDINYLQPLCEKIAIERAGADANIGD 94
Cdd:cd14755    1 AKKRLLDFLEEHQENFLSEWEKRILISEDDPFKEEIRKNGEAMLELVIEYLREEISEEYIKQLAYKVAEERVDANINIGD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446347231  95 FVYNANVGRNELFEAMCELDVSARELKPIMAKIHTCFDKLIYYTVLKYSEII 146
Cdd:cd14755   81 FVYNVNLGRSLIFKYLFKLNLPWDELQPIIDKINQCFDKFLYYAVSKYTELK 132
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
163-360 3.43e-37

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 141.64  E-value: 3.43e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 163 ERLTILGQMSASFVHEFRNPLTSIMGFVKLLK---ADHPSLSYLDIISHELDQLNFRISQFLLVSK--KEMWnesERFWL 237
Cdd:PRK11360 385 ERLAALGELVAGVAHEIRNPLTAIRGYVQIWRqqtSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRprESQW---QPVSL 461

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 238 NDLFQDIIQFLYPSLVNANVLIEKNLPYPIPLVGYRSE-VRQVFLNILMNsidALESMKEERKIIIDVFEE-DQAIRIVI 315
Cdd:PRK11360 462 NALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPElLKQVLLNILIN---AVQAISARGKIRIRTWQYsDGQVAVSI 538

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446347231 316 KNNGPMIPAENVETIFEPFVTTKKLGTGIGLFVCKQIVEKHNGSI 360
Cdd:PRK11360 539 EDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDI 583
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 276-373 8.55e-25

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 97.33  E-value: 8.55e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231   276 VRQVFLNILMNSIDAlesMKEERKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFVTTKKL-----GTGIGLFVCK 350
Cdd:smart00387   6 LRQVLSNLLDNAIKY---TPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkigGTGLGLSIVK 82

                           90       100
                   ....*....|....*....|....
gi 446347231   351 QIVEKHNGSIMCRSDND-WTEFQI 373
Cdd:smart00387  83 KLVELHGGEISVESEPGgGTTFTI 106
 
Name Accession Description Interval E-value
KinD COG5808
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...
 31-375 1.51e-59

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444510 [Multi-domain]  Cd Length: 454  Bit Score: 199.20  E-value: 1.51e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231  31 VENWKNKMIISEKDPFKLEVVQNGEDLLELIIELTMedkdinylQPLCEKIAIERAGADANIGDfVYNANVGRNELFEAM 110
Cdd:COG5808  132 MDYIRALINILDPDKYIEIVDQNGQSVFTSGHREES--------KSVSNKLDKVPWEVEVYPNP-VTNDELGQALAIRKL 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 111 CEldvsarelkpimakihtCFDKLIYYTVLKYSEIisKNLEEKQQYINETHKERLTILGQMSASFVHEFRNPLTSIMGFV 190
Cdd:COG5808  203 II-----------------LVLISIIFLLLQYNLL--KRKTLLERVIQEINTQKLELIGTFAASTAHEIRNPLTSIKGFI 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 191 KLLKADHPSL---SYLDIISHELDQLNFRISQFLLVSKKEMwNESERFWLNDLFQDIIQFLYPSLVNANVLIEKNLP-YP 266
Cdd:COG5808  264 QLLQEKYPELedqKYFDIIQEEIQRINQIVSEFLVLGKPTA-KKLELDDLNELIEEILSIIDSEANLKNIRVEKQSLdEP 342

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 267 IPLVGYRSEVRQVFLNILMNsidALESMKEERKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFVTTKKLGTGIGL 346
Cdd:COG5808  343 LHIKCDKDRIKQVLLNLIKN---AIEAMKEGGKLTISIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGL 419

                        330       340       350
                 ....*....|....*....|....*....|
gi 446347231 347 FVCKQIVEKHNGSIMCRSDND-WTEFQIAF 375
Cdd:COG5808  420 SVCKRIVEMHGGEIDIESEEGkGTTFTIRL 449
HisK_N pfam09385
Histidine kinase N terminal; This domain is found at the N terminal of sensor histidine kinase ...
 16-144 5.30e-57

Histidine kinase N terminal; This domain is found at the N terminal of sensor histidine kinase proteins.


Pssm-ID: 286473  Cd Length: 129  Bit Score: 182.11  E-value: 5.30e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231   16 KEIFCSHLKNNRHQFVENWKNKMIISEKDPFKLEVVQNGEDLLELIIELTMEDKDINYLQPLCEKIAIERAGADANIGDF 95
Cdd:pfam09385   1 KQVLVDYLEEHQPNFLSEWKKRILISDDDPYKDEIKQNGEALFSLVIEYLRESISLEDLERLAEKIAKERAEANVNIGDF 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 446347231   96 VYNANVGRNELFEAMCELDVSARELKPIMAKIHTCFDKLIYYTVLKYSE 144
Cdd:pfam09385  81 VYNVNVGRSEVINYLFKLNVPWDELQPIIDKINECFDKFLYYAVSKYTE 129
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 161-375 1.76e-56

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 188.47  E-value: 1.76e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 161 HKERLTILGQMSASFVHEFRNPLTSIMGFVKLLKA-------DHPSLSYLDIISHELDQLNFRISQFLLVSKKEMwNESE 233
Cdd:COG4191  135 QSEKLAALGELAAGIAHEINNPLAAILGNAELLRRrledepdPEELREALERILEGAERAAEIVRSLRAFSRRDE-EERE 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 234 RFWLNDLFQDIIQFLYPSLVNANVLIEKNLPYPIPLV-GYRSEVRQVFLNILMNSIDALESmKEERKIIIDVFEEDQAIR 312
Cdd:COG4191  214 PVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVlGDPGQLEQVLLNLLINAIDAMEE-GEGGRITISTRREGDYVV 292

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446347231 313 IVIKNNGPMIPAENVETIFEPFVTTKKL--GTGIGLFVCKQIVEKHNGSIMCRSD-NDWTEFQIAF 375
Cdd:COG4191  293 ISVRDNGPGIPPEVLERIFEPFFTTKPVgkGTGLGLSISYGIVEKHGGRIEVESEpGGGTTFTITL 358
GS_BA2291-HK-like cd14755
Non-heme globin sensor domain of BA2291 histidine kinase and related domains; This subfamily ...
 15-146 1.66e-55

Non-heme globin sensor domain of BA2291 histidine kinase and related domains; This subfamily includes the sensor domain of Bacillus anthracis BA2291 histidine kinase. BA2291 is one of the most active kinases in promoting sporulation, and is found in most members of the Bacillus cereus subfamily of the genus Bacillus, which includes B. anthracis and Bacillus thuringiensis, but not Bacillus subtilis. This subfamily also includes two sensor-only plasmid encoded sporulation inhibitors pXO1-118 and pXO2-61 found only in B. anthracis and various strains of Bacillus cereus having similar plasmids. The pXO1-118 and pXO2-61 sensor domains form homodimers, and in vitro bind fatty acid and halide, and not heme; there may be roles for fatty acid (or similar molecule), chloride ion, and possibly pH, as signaling cues. It has been proposed that BA2291 senses the same environmental cue in vivo, and that pXO1-118 and pXO2-61 act by titrating out an environmental signal that might cause an ill-timed sporulation.


Pssm-ID: 271288  Cd Length: 132  Bit Score: 178.58  E-value: 1.66e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231  15 IKEIFCSHLKNNRHQFVENWKNKMIISEKDPFKLEVVQNGEDLLELIIELTMEDKDINYLQPLCEKIAIERAGADANIGD 94
Cdd:cd14755    1 AKKRLLDFLEEHQENFLSEWEKRILISEDDPFKEEIRKNGEAMLELVIEYLREEISEEYIKQLAYKVAEERVDANINIGD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446347231  95 FVYNANVGRNELFEAMCELDVSARELKPIMAKIHTCFDKLIYYTVLKYSEII 146
Cdd:cd14755   81 FVYNVNLGRSLIFKYLFKLNLPWDELQPIIDKINQCFDKFLYYAVSKYTELK 132
KinC COG5807
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ...
 162-375 2.78e-54

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444509 [Multi-domain]  Cd Length: 358  Bit Score: 182.68  E-value: 2.78e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 162 KERLTILGQMSASFVHEFRNPLTSIMGFVKLLKADHPSL---SYLDIISHELDQLNFRISQFLLVSKKEMWNESErFWLN 238
Cdd:COG5807  141 SEKLSVAGELAAGIAHEIRNPLTSIKGFLQLLQESREDSereEYFNIIISEIDRINTIITELLVLSKPKKFNFKK-LNLN 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 239 DLFQDIIQFLYPSLVNANVLIEKNLPYPIPLV-GYRSEVRQVFLNILMNSIDAlesMKEERKIIIDVFEEDQAIRIVIKN 317
Cdd:COG5807  220 DVLEDVIALLSTEAILKNISIKYDLADDEPVInGDKNQLKQVFINLIKNAIEA---METGGNITIKTYVEGDFVVISVKD 296

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446347231 318 NGPMIPAENVETIFEPFVTTKKLGTGIGLFVCKQIVEKHNGSIMCRSD-NDWTEFQIAF 375
Cdd:COG5807  297 EGIGIPEEVLEKIGEPFFTTKEEGTGLGLSICKKIIEEHNGTIEVESKpGKGTTFTIYL 355
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
148-373 2.70e-51

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 175.03  E-value: 2.70e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 148 KNLEEKQQyinetHKERLTILGQMSASFVHEFRNPLTSIMGFVKLLK---ADHPSLSYLDIISHELDQLNFRISQFLLVS 224
Cdd:COG3852  120 KRLERELR-----RAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLErelPDDELREYTQLIIEEADRLNNLVDRLLSFS 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 225 KKEMwNESERFWLNDLFQDIIQFLYPSLvNANVLIEKNLPYPIPLV-GYRSEVRQVFLNILMNSIDAlesMKEERKIIID 303
Cdd:COG3852  195 RPRP-PEREPVNLHEVLERVLELLRAEA-PKNIRIVRDYDPSLPEVlGDPDQLIQVLLNLVRNAAEA---MPEGGTITIR 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 304 VFEEDQ----------AIRIVIKNNGPMIPAENVETIFEPFVTTKKLGTGIGLFVCKQIVEKHNGSIMCRS-DNDWTEFQ 372
Cdd:COG3852  270 TRVERQvtlgglrprlYVRIEVIDNGPGIPEEILDRIFEPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESePGKGTTFR 349


                 .
gi 446347231 373 I 373
Cdd:COG3852  350 I 350
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 145-365 4.77e-49

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 172.08  E-value: 4.77e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 145 IISKNLEEKQQYINE-THKERLTILGQMSASFVHEFRNPLTSIMGFVKLLKADHPS--LSYLDIISHELDQLNFRISQFL 221
Cdd:COG5809  246 IIFRDITERKKLEELlRKSEKLSVVGELAAGIAHEIRNPLTSLKGFIQLLKDTIDEeqKTYLDIMLSELDRIESIISEFL 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 222 LVSKKEMWNEsERFWLNDLFQDIIQFLYPSLVNANVLIEKNLPYPIPLV-GYRSEVRQVFLNILMNSIdalESMKEERKI 300
Cdd:COG5809  326 VLAKPQAIKY-EPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIPDIlGDENQLKQVFINLLKNAI---EAMPEGGNI 401

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446347231 301 IIDV-FEEDQAIRIVIKNNGPMIPAENVETIFEPFVTTKKLGTGIGLFVCKQIVEKHNGSIMCRSD 365
Cdd:COG5809  402 TIETkAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVESE 467
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 161-375 2.83e-48

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 168.60  E-value: 2.83e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 161 HKERLTILGQMSASFVHEFRNPLTSIMGFVKLLK--------ADHPSLS-YLDIISHELDQLNFRISQFLLVSKKEmWNE 231
Cdd:COG5000  194 RAERLAAWGELARRIAHEIKNPLTPIQLSAERLRrkladkleEDREDLErALDTIIRQVDRLKRIVDEFLDFARLP-EPQ 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 232 SERFWLNDLFQDIIQFLYPSLVNANVLIEKNLPYPIPLV-GYRSEVRQVFLNILMNsidALESMKEERKIIIDVFEEDQA 310
Cdd:COG5000  273 LEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVlADRDQLEQVLINLLKN---AIEAIEEGGEIEVSTRREDGR 349

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446347231 311 IRIVIKNNGPMIPAENVETIFEPFVTTKKLGTGIGLFVCKQIVEKHNGSIMCRS-DNDWTEFQIAF 375
Cdd:COG5000  350 VRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEEHGGTIELESrPGGGTTFTIRL 415
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
168-375 6.97e-47

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 162.77  E-value: 6.97e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 168 LGQMSASFVHEFRNPLTSIMGFVKLLKADHPS--LSYLDIISHELDQLNFRISQFLLVSKKE---MWNESERFWLNDLFQ 242
Cdd:COG0642  110 KSRFLANVSHELRTPLTAIRGYLELLLEELDEeqREYLETILRSADRLLRLINDLLDLSRLEagkLELEPEPVDLAELLE 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 243 DIIQFLYPSLVNANVLIEKNLPYPIPLV-GYRSEVRQVFLNILMNSIDAlesMKEERKIIIDVFEEDQAIRIVIKNNGPM 321
Cdd:COG0642  190 EVVELFRPLAEEKGIELELDLPDDLPTVrGDPDRLRQVLLNLLSNAIKY---TPEGGTVTVSVRREGDRVRISVEDTGPG 266

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446347231 322 IPAENVETIFEPFVTTKKL----GTGIGLFVCKQIVEKHNGSIMCRS-DNDWTEFQIAF 375
Cdd:COG0642  267 IPPEDLERIFEPFFRTDPSrrggGTGLGLAIVKRIVELHGGTIEVESePGKGTTFTVTL 325
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 161-377 8.31e-44

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 158.36  E-value: 8.31e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 161 HKERLTILGQMSASFVHEFRNPLTSIMGFVKLLKA-----DHpslsYLDIISHELDQLNFRISQFLLVSKkEMWNESERF 235
Cdd:COG5805  280 RSEKLSIAGQLAAGIAHEIRNPLTSIKGFLQLLQPgiedkEE----YFDIMLSELDRIESIISEFLALAK-PQAVNKEKE 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 236 WLNDLFQDIIQFLYPSLVNANVLIEKNLPYPIP-LVGYRSEVRQVFLNILMNSIDAlesMKEERKIIIDVFEEDQAIRIV 314
Cdd:COG5805  355 NINELIQDVVTLLETEAILHNIQIRLELLDEDPfIYCDENQIKQVFINLIKNAIEA---MPNGGTITIHTEEEDNSVIIR 431

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446347231 315 IKNNGPMIPAENVETIFEPFVTTKKLGTGIGLFVCKQIVEKHNGSIMCRSDNDW-TEFQIAFQK 377
Cdd:COG5805  432 VIDEGIGIPEERLKKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKgTTFTITLPL 495
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
150-375 7.61e-42

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 146.59  E-value: 7.61e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 150 LEEKQQYINETHKERLTILGQMSasfvHEFRNPLTSIMGFVKLLKADHPSLS-----YLDIISHELDQLNFRISQFLLVS 224
Cdd:COG2205    2 LEEALEELEELERLKSEFLANVS----HELRTPLTSILGAAELLLDEEDLSPeerreLLEIIRESAERLLRLIEDLLDLS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 225 KKEMWN---ESERFWLNDLFQDIIQFLYPSLVNANVLIEKNLPYPIPLV-GYRSEVRQVFLNILMNSIDAlesMKEERKI 300
Cdd:COG2205   78 RLESGKlslELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVyADPELLEQVLANLLDNAIKY---SPPGGTI 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 301 IIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFV----TTKKLGTGIGLFVCKQIVEKHNGSIMCRSDNDW-TEFQIAF 375
Cdd:COG2205  155 TISARREGDGVRISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGgTTFTVTL 234
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
170-373 9.88e-38

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 139.69  E-value: 9.88e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 170 QMSASFV----HEFRNPLTSIMGFVKLLKADHPSLS-----YLDIISHELDQLNFRISQFLLVSK---KEMWNESERFWL 237
Cdd:COG5002  163 QMRREFVanvsHELRTPLTSIRGYLELLLDGAADDPeerreYLEIILEEAERLSRLVNDLLDLSRlesGELKLEKEPVDL 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 238 NDLFQDIIQFLYPSLVNANVLIEKNLPYPIPLV-GYRSEVRQVFLNILMNsidALESMKEERKIIIDVFEEDQAIRIVIK 316
Cdd:COG5002  243 AELLEEVVEELRPLAEEKGIELELDLPEDPLLVlGDPDRLEQVLTNLLDN---AIKYTPEGGTITVSLREEDDQVRISVR 319

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446347231 317 NNGPMIPAENVETIFEPFVTTKKL------GTGIGLFVCKQIVEKHNGSIMCRSD-NDWTEFQI 373
Cdd:COG5002  320 DTGIGIPEEDLPRIFERFYRVDKSrsretgGTGLGLAIVKHIVEAHGGRIWVESEpGKGTTFTI 383
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
163-360 3.43e-37

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 141.64  E-value: 3.43e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 163 ERLTILGQMSASFVHEFRNPLTSIMGFVKLLK---ADHPSLSYLDIISHELDQLNFRISQFLLVSK--KEMWnesERFWL 237
Cdd:PRK11360 385 ERLAALGELVAGVAHEIRNPLTAIRGYVQIWRqqtSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRprESQW---QPVSL 461

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 238 NDLFQDIIQFLYPSLVNANVLIEKNLPYPIPLVGYRSE-VRQVFLNILMNsidALESMKEERKIIIDVFEE-DQAIRIVI 315
Cdd:PRK11360 462 NALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPElLKQVLLNILIN---AVQAISARGKIRIRTWQYsDGQVAVSI 538

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446347231 316 KNNGPMIPAENVETIFEPFVTTKKLGTGIGLFVCKQIVEKHNGSI 360
Cdd:PRK11360 539 EDNGCGIDPELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDI 583
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 172-364 9.15e-26

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 108.33  E-value: 9.15e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 172 SASfvHEFRNPLTSIMGFVKLLKADHPS------LSYLDII---SHELDQLnfrIS---QFLLVSKKEMwnESERFWLND 239
Cdd:COG4251  288 VAS--HDLREPLRKISGFSQLLEEDYGDkldeegREYLERIrdaAERMQAL---IDdllAYSRVGRQEL--EFEPVDLNE 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 240 LFQDIIQFLYPSLVNANVLIE-KNLPypiPLVGYRSEVRQVFLNILMNsidALESMKEER--KIIIDVFEEDQAIRIVIK 316
Cdd:COG4251  361 LLEEVLEDLEPRIEERGAEIEvGPLP---TVRGDPTLLRQVFQNLISN---AIKYSRPGEppRIEIGAEREGGEWVFSVR 434

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446347231 317 NNGPMIPAENVETIFEPFvttKKL-------GTGIGLFVCKQIVEKHNGSIMCRS 364
Cdd:COG4251  435 DNGIGIDPEYAEKIFEIF---QRLhsrdeyeGTGIGLAIVKKIVERHGGRIWVES 486
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 276-373 8.55e-25

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 97.33  E-value: 8.55e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231   276 VRQVFLNILMNSIDAlesMKEERKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFVTTKKL-----GTGIGLFVCK 350
Cdd:smart00387   6 LRQVLSNLLDNAIKY---TPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkigGTGLGLSIVK 82

                           90       100
                   ....*....|....*....|....
gi 446347231   351 QIVEKHNGSIMCRSDND-WTEFQI 373
Cdd:smart00387  83 KLVELHGGEISVESEPGgGTTFTI 106
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
148-364 4.32e-24

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 102.94  E-value: 4.32e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 148 KNLEEKQQYINET-HKERLTILGQMSASFVHEFRNPLTSIMGFVKLLKADHPSLS----YLDIISHELDQLNFRISQFL- 221
Cdd:PRK10364 216 RYLRSRQLLQDEMkRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERAPAGGeahqLAQVMAKEADRLNRVVSELLe 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 222 LVSKKEMWNESERfwLNDLFQDIIQFLYPSLVNANVLIEKNLPYPIPLVGYRSE-VRQVFLNILMNSIDAlesMKEERKI 300
Cdd:PRK10364 296 LVKPTHLALQAVD--LNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDrLTQVLLNLYLNAIQA---IGQHGVI 370

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446347231 301 IIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFVTTKKLGTGIGLFVCKQIVEKHNGSIMCRS 364
Cdd:PRK10364 371 SVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVAS 434
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 144-373 4.90e-22

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 96.46  E-value: 4.90e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 144 EIISKNLEEKQQYINETHKERltilgqmsasfvHEFRNPLTSIMGFVKLLKADHpSLSYLDIISHELDQLNFRISQF--- 220
Cdd:COG3290  177 ERLEEELEGVKELAEALRAQR------------HDFRNHLHTISGLLQLGEYDE-ALEYIDEISEELQELIDSLLSRign 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 221 -----LLVSKKEMWNESErfwlndlfqdiiqflypslVNANVLIEKNLPyPIPLVGYrsEVRQVFLNILMNSIDALESMK 295
Cdd:COG3290  244 pvlaaLLLGKAARARERG-------------------IDLTIDIDSDLP-DLPLSDT--DLVTILGNLLDNAIEAVEKLP 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 296 -EERKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFVTTK-KLGTGIGLFVCKQIVEKHNGSIMCRSDNDW-TEFQ 372
Cdd:COG3290  302 eEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKlGEGRGLGLALVKQIVEKYGGTIEVESEEGEgTVFT 381


                 .
gi 446347231 373 I 373
Cdd:COG3290  382 V 382
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 273-364 1.07e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 85.94  E-value: 1.07e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 273 RSEVRQVFLNILMNsidALESMKEERKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFVTTKKL--GTGIGLFVCK 350
Cdd:cd16943    1 PSQLNQVLLNLLVN---AAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVgeGTGLGLSLSY 77

                         90
                 ....*....|....
gi 446347231 351 QIVEKHNGSIMCRS 364
Cdd:cd16943   78 RIIQKHGGTIRVAS 91
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 276-360 4.01e-20

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 84.37  E-value: 4.01e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 276 VRQVFLNILMNSIDALESMKEERKIIIDVFE--EDQAIRIVIKNNGPMIPAENVETIFEPFVTTKKLGTGIGLFVCKQIV 353
Cdd:cd16920    1 IQQVLINLVRNGIEAMSEGGCERRELTIRTSpaDDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSII 80


                 ....*..
gi 446347231 354 EKHNGSI 360
Cdd:cd16920   81 EAHGGRL 87
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 278-373 1.12e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 80.52  E-value: 1.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 278 QVFLNILMNSIDALESMKEErkIIIDVFEEDQ----------AIRIVIKNNGPMIPAENVETIFEPFVTTKKLGTGIGLF 347
Cdd:cd16918    3 QVFLNLVRNAAQALAGSGGE--IILRTRTQRQvtlghprhrlALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80

                         90       100
                 ....*....|....*....|....*.
gi 446347231 348 VCKQIVEKHNGSIMCRSDNDWTEFQI 373
Cdd:cd16918   81 IAQNIVSQHGGVIECDSQPGHTVFSV 106
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 271-373 2.31e-18

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 79.72  E-value: 2.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231  271 GYRSEVRQVFLNILMNSIDAlesMKEERKIIIDVfEEDQAIRIVIKNNGPMIPAENVETIFEPFVTTKKL---GTGIGLF 347
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKH---AAKAGEITVTL-SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRgggGTGLGLS 76

                          90       100
                  ....*....|....*....|....*..
gi 446347231  348 VCKQIVEKHNGSIMCRS-DNDWTEFQI 373
Cdd:pfam02518  77 IVRKLVELLGGTITVESePGGGTTVTL 103
PRK09303 PRK09303
histidine kinase;
153-360 2.53e-18

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 85.39  E-value: 2.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 153 KQQyiNETHKERLTILGQMSASFVHEFRNPLT--SI------MGFVKLLKADHPSL--SYLDIISHELDQLNfRISQFLL 222
Cdd:PRK09303 138 RQE--NETLLEQLKFKDRVLAMLAHDLRTPLTaaSLaletleLGQIDEDTELKPALieQLQDQARRQLEEIE-RLITDLL 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 223 VSKKEMWNE----SERFWLNDLFQDIIQFLYPSLVNANVLIEKNLPYPIPLV-GYRSEVRQVFLNILMNsidALESMKEE 297
Cdd:PRK09303 215 EVGRTRWEAlrfnPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLPSVyADQERIRQVLLNLLDN---AIKYTPEG 291

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446347231 298 RKIIIDVFEE-DQAIRIVIKNNGPMIPAENVETIFEPFVTTK----KLGTGIGLFVCKQIVEKHNGSI 360
Cdd:PRK09303 292 GTITLSMLHRtTQKVQVSICDTGPGIPEEEQERIFEDRVRLPrdegTEGYGIGLSVCRRIVRVHYGQI 359
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 276-371 2.11e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 74.03  E-value: 2.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 276 VRQVFLNILMNSIDALESMKEERkiiIDVFEEDQAIR--IVIKNNGPMIPAENVETIFEPFVTTKKL--GTGIGLFVCKQ 351
Cdd:cd16976    1 IQQVLMNLLQNALDAMGKVENPR---IRIAARRLGGRlvLVVRDNGPGIAEEHLSRVFDPFFTTKPVgkGTGLGLSISYG 77

                         90       100
                 ....*....|....*....|.
gi 446347231 352 IVEKHNGSIMCRSDND-WTEF 371
Cdd:cd16976   78 IVEEHGGRLSVANEEGaGARF 98
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 273-360 3.24e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 73.73  E-value: 3.24e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 273 RSEVRQVFLNILMNSIDALESMKEER-KIIIDVfEEDQAIRIV--IKNNGPMIPAENVETIFEPFVTTKKLGTGIGLFVC 349
Cdd:cd16944    2 TTQISQVLTNILKNAAEAIEGRPSDVgEVRIRV-EADQDGRIVliVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIV 80

                         90
                 ....*....|.
gi 446347231 350 KQIVEKHNGSI 360
Cdd:cd16944   81 KKIMEEHGGRI 91
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 144-361 9.74e-16

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 78.57  E-value: 9.74e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 144 EIISKNLEEKQQYINETHKerLTILGQMSASFVHEFRNPLTSIMGFVKLLKA------DHPSLSYLDIISHELDQLNFRI 217
Cdd:COG4192  411 KRIEKNLRQTQDELIQAAK--MAVVGQTMTSLAHELNQPLNAMSMYLFSAKKaleqenYAQLPTSLDKIEGLIERMDKII 488

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 218 SQFLLVSKKEmwNESERFW-LNDLFQDIIQFLypSLVNANVLIEKNLPYPIPLVGYRSEVRQVFLNILMNSIDAlesMKE 296
Cdd:COG4192  489 KSLRQFSRKS--DTPLQPVdLRQVIEQAWELV--ESRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDA---VAT 561

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446347231 297 ERKIIIDVFEEDQAIRIVIKNNGPMIPAenVETIFEPFVTTKKLGTGIGLFVCKQIVEKHNGSIM 361
Cdd:COG4192  562 QPQISVDLLSNAENLRVAISDNGNGWPL--VDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLY 624
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
161-364 1.75e-15

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 78.18  E-value: 1.75e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 161 HKERLTILGQMSASFVHEFRNPLTSIMGFVKL----LKADHPSLSYLDIISHELDQLNFRISQFLLVSKKEMWNeSERFW 236
Cdd:PRK13837 443 HARRLEAVGTLASGIAHNFNNILGAILGYAEMalnkLARHSRAARYIDEIISAGARARLIIDQILAFGRKGERN-TKPFD 521

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 237 LNDLFQDIIQFLYPSLVNANVLIEKNLPYPIPLVGYRSEVRQVFLNILMNsidALESMKEERKIIIDVFEED-------- 308
Cdd:PRK13837 522 LSELVTEIAPLLRVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSN---AAQAMDGAGRVDISLSRAKlrapkvls 598

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446347231 309 -------QAIRIVIKNNGPMIPAENVETIFEPFVTTKKLGTGIGLFVCKQIVEKHNGSIMCRS 364
Cdd:PRK13837 599 hgvlppgRYVLLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQS 661
glnL PRK11073
nitrogen regulation protein NR(II);
177-373 7.34e-15

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 74.73  E-value: 7.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 177 HEFRNPLTSIMGFVKLL-KA-DHPSLS-YLDIISHELDQLNFRISQFLLVSKKEMwneserfwlnDLFQDIIQFL--YPS 251
Cdd:PRK11073 139 HEIKNPLGGLRGAAQLLsKAlPDPALTeYTKVIIEQADRLRNLVDRLLGPQRPGT----------HVTESIHKVAerVVQ 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 252 LVN----ANVLIEKNLPYPIP-LVGYRSEVRQVFLNILMNSIDALEsmKEERKIIIDVFEEDQ----------AIRIVIK 316
Cdd:PRK11073 209 LVSlelpDNVRLIRDYDPSLPeLAHDPDQIEQVLLNIVRNALQALG--PEGGTITLRTRTAFQltlhgeryrlAARIDIE 286

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 317 NNGPMIPAENVETIFEPFVTTKKLGTGIGLFVCKQIVEKHNGSIMCRSdndW---TEFQI 373
Cdd:PRK11073 287 DNGPGIPPHLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFTS---WpghTEFSV 343
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 276-364 2.28e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 62.90  E-value: 2.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 276 VRQVFLNILMNSIdalesmK--EERKIIIDV-----FEEDQAIRIVIKNNGPMIPAENVETIFEPFV-----TTKKL-GT 342
Cdd:cd16922    1 LRQILLNLLGNAI------KftEEGEVTLRVsleeeEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSqadssTTRKYgGT 74

                         90       100
                 ....*....|....*....|..
gi 446347231 343 GIGLFVCKQIVEKHNGSIMCRS 364
Cdd:cd16922   75 GLGLAISKKLVELMGGDISVES 96
envZ PRK09467
osmolarity sensor protein; Provisional
 177-360 3.07e-12

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 67.63  E-value: 3.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 177 HEFRNPLTSI------MGfvkllkadhPSLSYL-DIISHELDQLNFRISQFL--LVSKKEMwnESERFWLNDLFQDIIQf 247
Cdd:PRK09467 238 HDLRTPLTRIrlatemMS---------EEDGYLaESINKDIEECNAIIEQFIdyLRTGQEM--PMEMADLNALLGEVIA- 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 248 lypSLVNANVLIEKNL-PYPIPLVGYRSEVRQVFLNILMNSIdalesmkeeR----KIIIDVFEEDQAIRIVIKNNGPMI 322
Cdd:PRK09467 306 ---AESGYEREIETALqPGPIEVPMNPIAIKRALANLVVNAA---------RygngWIKVSSGTEGKRAWFQVEDDGPGI 373

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 446347231 323 PAENVETIFEPFVTTKK----LGTGIGLFVCKQIVEKHNGSI 360
Cdd:PRK09467 374 PPEQLKHLFQPFTRGDSargsSGTGLGLAIVKRIVDQHNGKV 415
PRK10490 PRK10490
sensor protein KdpD; Provisional
 163-360 1.68e-11

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 65.83  E-value: 1.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 163 ERLTILGQMSASFVHEFRNPLTSIMGFVKLLKADHPS----------------LSYLDIISHELDQLNFRISQFLLvsKK 226
Cdd:PRK10490 659 EREQLRNALLAALSHDLRTPLTVLFGQAEILTLDLASegspharqaseirqqvLNTTRLVNNLLDMARIQSGGFNL--RK 736

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 227 EmWNEserfwLNDLFQDIIQFLYPSLVNANvlIEKNLPYPIPLV-GYRSEVRQVFLNILMNsidALESMKEERKIIIDVF 305
Cdd:PRK10490 737 E-WLT-----LEEVVGSALQMLEPGLSGHP--INLSLPEPLTLIhVDGPLFERVLINLLEN---AVKYAGAQAEIGIDAH 805

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446347231 306 EEDQAIRIVIKNNGPMIPAENVETIFEPFVTTKKL----GTGIGLFVCKQIVEKHNGSI 360
Cdd:PRK10490 806 VEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKEsaipGVGLGLAICRAIVEVHGGTI 864
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 282-360 1.87e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 60.38  E-value: 1.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 282 NILMNSIDALESMKEERKII-IDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFVTTKKLGT-GIGLFVCKQIVEKHNGS 359
Cdd:cd16915    7 NLIDNALDALAATGAPNKQVeVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGErGIGLALVRQSVERLGGS 86


                 .
gi 446347231 360 I 360
Cdd:cd16915   87 I 87
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 277-373 1.93e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 60.09  E-value: 1.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 277 RQVFLNILMNSIDAleSMKEERkIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFV----TTKKLGTGIGLFVCKQI 352
Cdd:cd16923    2 QRVFSNLLSNAIKY--SPENTR-IYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYrgdnSRNTEGAGLGLSIAKAI 78

                         90       100
                 ....*....|....*....|.
gi 446347231 353 VEKHNGSIMCRSDNDWTEFQI 373
Cdd:cd16923   79 IELHGGSASAEYDDNHDLFKV 99
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
177-360 1.08e-10

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 62.64  E-value: 1.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 177 HEFRNPLTSIMGFVKLLK---ADHPSLSYLDIISHELDQLnfrISQFLLVSKKEMWN--ESERFWLNDLFQDIIQflyps 251
Cdd:PRK09470 252 HELRTPLTRLQLATALLRrrqGESKELERIETEAQRLDSM---INDLLVLSRNQQKNhlERETFKANSLWSEVLE----- 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 252 lvNANVLIE---KNL-----PYPIPLVGYRSEVRQVFLNILMNSIDALESmkeerKIIIDVFEEDQAIRIVIKNNGPMIP 323
Cdd:PRK09470 324 --DAKFEAEqmgKSLtvsapPGPWPINGNPNALASALENIVRNALRYSHT-----KIEVAFSVDKDGLTITVDDDGPGVP 396

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446347231 324 AENVETIFEPFVTTKKL------GTGIGLFVCKQIVEKHNGSI 360
Cdd:PRK09470 397 EEEREQIFRPFYRVDEArdresgGTGLGLAIVENAIQQHRGWV 439
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 283-375 1.28e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 58.07  E-value: 1.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 283 ILMNsidALESMKEERKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFVTTK-----KLGTGIGLFVCKQIVEKHN 357
Cdd:cd16948   13 IVSN---ALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrnfQESTGMGLYLVKKLCDKLG 89

                         90
                 ....*....|....*....
gi 446347231 358 GSIMCRSD-NDWTEFQIAF 375
Cdd:cd16948   90 HKIDVESEvGEGTTFTITF 108
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 278-367 2.46e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 57.20  E-value: 2.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 278 QVFLNILMNSIDAleSMKEERKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFVTTKKLG------TGIGLFVCKQ 351
Cdd:cd16953    3 QVLRNLIGNAISF--SPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANeafgqhSGLGLSISRQ 80

                         90
                 ....*....|....*.
gi 446347231 352 IVEKHNGSIMCRSDND 367
Cdd:cd16953   81 IIEAHGGISVAENHNQ 96
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 166-364 4.88e-10

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 61.07  E-value: 4.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 166 TILGQMSasfvHEFRNPLTSIMGFVKLLkADHPSLS----YLDIISHELDQLNFRISQFLLVSKKEMWNES-----ERFW 236
Cdd:PRK11466 446 AFLAAMS----HEIRTPLYGILGTAQLL-ADNPALNaqrdDLRAITDSGESLLTILNDILDYSAIEAGGKNvsvsdEPFE 520

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 237 LNDLFQDIIQFLYPSLVNANVLIEKNLPYPIP--LVGYRSEVRQVFLNILMNSIdaleSMKEERKIIIDVFEEDQAIRIV 314
Cdd:PRK11466 521 PRPLLESTLQLMSGRVKGRPIRLATDIADDLPtaLMGDPRRIRQVITNLLSNAL----RFTDEGSIVLRSRTDGEQWLVE 596

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446347231 315 IKNNGPMIPAENVETIFEPFV--TTKKLGTGIGLFVCKQIVEKHNGSIMCRS 364
Cdd:PRK11466 597 VEDSGCGIDPAKLAEIFQPFVqvSGKRGGTGLGLTISSRLAQAMGGELSATS 648
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 168-227 5.63e-10

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 54.91  E-value: 5.63e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446347231  168 LGQMSASFVHEFRNPLTSIMGFVKLLKADHPSLS---YLDIISHELDQLNFRISQFLLVSKKE 227
Cdd:pfam00512   2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEqreYLETILRSAERLLRLINDLLDLSRIE 64
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 168-227 6.34e-10

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 54.88  E-value: 6.34e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446347231   168 LGQMSASFVHEFRNPLTSIMGFVKLLKADHPSLS---YLDIISHELDQLNFRISQFLLVSKKE 227
Cdd:smart00388   2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEqreYLETILREAERLLRLINDLLDLSRIE 64
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 168-225 1.71e-09

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 53.37  E-value: 1.71e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446347231 168 LGQMSASFVHEFRNPLTSIMGFVKLLKADHPSLS----YLDIISHELDQLNFRISQFLLVSK 225
Cdd:cd00082    4 KGEFLANVSHELRTPLTAIRGALELLEEELLDDEeqreYLERIREEAERLLRLINDLLDLSR 65
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 282-373 1.89e-09

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 59.16  E-value: 1.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 282 NILMNSIDALESMkEERKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFVTTKKLGTGIGLFVCKQIVEKHNGSIM 361
Cdd:PRK11086 440 NLIENALEAVGGE-EGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIA 518

                         90
                 ....*....|...
gi 446347231 362 CRSD-NDWTEFQI 373
Cdd:PRK11086 519 VESEpGVGTQFFV 531
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 276-360 2.77e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 54.26  E-value: 2.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 276 VRQVFLNILMNSIdalESMKEERKIIIDVFEEDQAI--RIVIKNNGPMIPAENVETIFEPFvttKKL-------GTGIGL 346
Cdd:cd16921    1 LGQVLTNLLGNAI---KFRRPRRPPRIEVGAEDVGEewTFYVRDNGIGIDPEYAEKVFGIF---QRLhsreeyeGTGVGL 74

                         90
                 ....*....|....
gi 446347231 347 FVCKQIVEKHNGSI 360
Cdd:cd16921   75 AIVRKIIERHGGRI 88
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 273-360 6.41e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 53.24  E-value: 6.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 273 RSEVRQVFLNILMNSIDALESMKeerKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFVTTKKL------GTGIGL 346
Cdd:cd16946    2 RDRLQQLFVNLLENSLRYTDTGG---KLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnrasgGSGLGL 78

                         90
                 ....*....|....
gi 446347231 347 FVCKQIVEKHNGSI 360
Cdd:cd16946   79 AICHNIALAHGGTI 92
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 298-360 1.15e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 52.33  E-value: 1.15e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446347231 298 RKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPF------VTTKKLGTGIGLFVCKQIVEKHNGSI 360
Cdd:cd16949   18 SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFyrvdsaRDRESGGTGLGLAIAERAIEQHGGKI 86
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
277-377 1.51e-08

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 56.32  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 277 RQVFLNILMNsidALESMKEERKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFVTT------KKLGTGIGLFVCK 350
Cdd:PRK09835 377 RRAISNLLSN---ALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVdpsrqrKGEGSGIGLAIVK 453

                         90       100
                 ....*....|....*....|....*..
gi 446347231 351 QIVEKHNGSIMCRSDNDWTEFQIAFQK 377
Cdd:PRK09835 454 SIVVAHKGTVAVTSDARGTRFVISLPR 480
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 311-360 3.16e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 50.91  E-value: 3.16e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446347231 311 IRIVIKNNGPMIPAENVETIFEPFVTTKK----LGTGIGLFVCKQIVEKHNGSI 360
Cdd:cd16950   31 TRIQVLDNGPGIAPEEVDELFQPFYRGDNargtSGTGLGLAIVQRISDAHGGSL 84
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
256-361 3.61e-08

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 55.02  E-value: 3.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 256 NVLIEKNLPYPIPLVGYRSEVRQVFLNILMNSidaLESMKEERKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFV 335
Cdd:PRK10549 333 GLTLQLSLPDSATVFGDPDRLMQLFNNLLENS---LRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFY 409

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446347231 336 TTKKL------GTGIGLFVCKQIVEKHNGSIM 361
Cdd:PRK10549 410 RTEGSrnrasgGSGLGLAICLNIVEAHNGRII 441
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 279-375 5.14e-08

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 50.29  E-value: 5.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231  279 VFLNILMNSIDALESMKEERKIIIDVFEEDQAIRIVIKNngpmiPAENVETIFEPFVTTKKLGT--GIGLFVCKQIVEKH 356
Cdd:pfam14501   9 IFGNLLDNAIEACSKIDDNRFIRLKIREKQNFLIIRIEN-----TYEGELKFEGKLPSTKTKGDghGIGLKSIRRIVKKY 83

                          90
                  ....*....|....*....
gi 446347231  357 NGSIMCRSDNDWTEFQIAF 375
Cdd:pfam14501  84 GGNLSTEIENGIFTLSILL 102
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 177-360 5.89e-08

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 54.47  E-value: 5.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 177 HEFRNPLTSIMGFVKLLKADHPS---LSYLDIISHE---LDQLnfrISQFLLVSKKEMWN---ESERFWLNDLFQDIIQF 247
Cdd:PRK11100 265 HELKSPLAAIRGAAELLQEDPPPedrARFTGNILTQsarLQQL---IDRLLELARLEQRQeleVLEPVALAALLEELVEA 341

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 248 LYPSLVNANVLIEKNLPyPIPLVGYRSEVRQVFLNILMNSIDAlesMKEERKIIIDVFEEDQAIRIVIKNNGPMIPAENV 327
Cdd:PRK11100 342 REAQAAAKGITLRLRPD-DARVLGDPFLLRQALGNLLDNAIDF---SPEGGTITLSAEVDGEQVALSVEDQGPGIPDYAL 417

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 446347231 328 ETIFEPFVT-----TKKLGTGIGL-FVcKQIVEKHNGSI 360
Cdd:PRK11100 418 PRIFERFYSlprpaNGRKSTGLGLaFV-REVARLHGGEV 455
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 278-360 1.08e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 49.77  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 278 QVFLNILMNSIDaleSMKEERKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFVTTKKLGT-----GIGLFVCKQI 352
Cdd:cd16975    7 RALINIISNACQ---YAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRsgghyGMGLYIAKNL 83


                 ....*...
gi 446347231 353 VEKHNGSI 360
Cdd:cd16975   84 VEKHGGSL 91
PRK15347 PRK15347
two component system sensor kinase;
177-364 1.33e-07

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 53.49  E-value: 1.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 177 HEFRNPLTSIMGFVKLLK--------------ADHPSLSYLDIISHELDqlnF-RIsqfllvskkemwnESERFWLN--- 238
Cdd:PRK15347 407 HEIRTPLNGVLGALELLQntpltaeqmdladtARQCTLSLLAIINNLLD---FsRI-------------ESGQMTLSlee 470

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 239 -DLFQDIIQFLY----PSL---VNANVLIEKNLPYPIPLVGYRseVRQVFLNILMNSIdaleSMKEERKIIIDVFEEDQA 310
Cdd:PRK15347 471 tALLPLLDQAMLtiqgPAQsksLTLRTFVGAHVPLYLHLDSLR--LRQILVNLLGNAV----KFTETGGIRLRVKRHEQQ 544

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446347231 311 IRIVIKNNGPMIPAENVETIFEPF--VTTKKLGTGIGLFVCKQIVEKHNGSIMCRS 364
Cdd:PRK15347 545 LCFTVEDTGCGIDIQQQQQIFTPFyqADTHSQGTGLGLTIASSLAKMMGGELTLFS 600
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 278-365 1.28e-06

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 46.99  E-value: 1.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 278 QVFLNILMNSIDAlesMKEERKIIIDVFEE---------------DQAIRIVIKNNGPMIPAENVETIFEPFVTTKKL-- 340
Cdd:cd16919    3 LAILNLAVNARDA---MPEGGRLTIETSNQrvdadyalnyrdlipGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVgk 79

                         90       100
                 ....*....|....*....|....*
gi 446347231 341 GTGIGLFVCKQIVEKHNGSIMCRSD 365
Cdd:cd16919   80 GTGLGLSMVYGFVKQSGGHLRIYSE 104
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 279-373 2.41e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 46.42  E-value: 2.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 279 VFLNILMNSIDA-LESMKEERKIIIDVFEEDQAIRIVIKNNGPmipaENVETIFEPFVTTKK-LGTGIGLFVCKQIVEKH 356
Cdd:cd16935   40 IFGNLLDNAIEAcAKIDKENRFIHLKIRQKKGFLIISIENSYE----GELKKKNGLFLSTKKdKNHGIGLKSIREIVKKY 115

                         90
                 ....*....|....*..
gi 446347231 357 NGSIMCRSDNDWTEFQI 373
Cdd:cd16935  116 NGNLSIEYENGIFTLSI 132
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 276-362 4.69e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 44.73  E-value: 4.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 276 VRQVFLNILMNSIdalesMKEERKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFV------TTKKLGTGIGLFVC 349
Cdd:cd16939    1 MARALDNLLRNAL-----RYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldpsrDRATGGFGLGLAIV 75

                         90
                 ....*....|...
gi 446347231 350 KQIVEKHNGSIMC 362
Cdd:cd16939   76 HRVALWHGGHVEC 88
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
290-359 5.37e-06

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 48.09  E-value: 5.37e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 290 ALESMKEERKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFvTTKKLGTGIGLFVCKQIVEKHNGS 359
Cdd:COG2972  352 GIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-SSKGEGRGIGLRNVRERLKLYYGE 420
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 301-360 6.56e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 44.70  E-value: 6.56e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446347231 301 IIDV-FEEDQAIRIVIKNNGPMIPAENVETIFEPFVTTKKL---GTGIGLFVCKQIVEKHNGSI 360
Cdd:cd16940   34 RVEIkLSADDGAVIRVEDNGPGIDEEELEALFERFYRSDGQnygGSGLGLSIVKRIVELHGGQI 97
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 276-367 8.93e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 43.99  E-value: 8.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 276 VRQVFLNILMNSIDAlesMKEERKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPFVT-----TKKLGTGIGLFVCK 350
Cdd:cd16945    5 LRQAINNLLDNAIDF---SPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFVQ 81

                         90
                 ....*....|....*..
gi 446347231 351 QIVEKHNGSIMCRSDND 367
Cdd:cd16945   82 EVAQLHGGRITLRNRPD 98
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 311-360 2.26e-05

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 43.25  E-value: 2.26e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446347231 311 IRIVIKNNGPMIPAENVETIFEPF------VTTKKLGTGIGLFVCKQIVEKHNGSI 360
Cdd:cd16925   38 FLLTVSDSGPGIPPNLREEIFERFrqgdgsSTRAHGGTGLGLSIVKEFVELHGGTV 93
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
302-360 3.44e-05

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 45.78  E-value: 3.44e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446347231 302 IDVFEEDQAIRIVIKNNGPMIPAENVETIFE--PFVTTKKLGTGIGLFVCKQIVEKHNGSI 360
Cdd:PRK10815 400 ISARQTDEHLHIVVEDDGPGIPESKRELIFDrgQRADTLRPGQGLGLSVAREITEQYEGKI 460
PRK13557 PRK13557
histidine kinase; Provisional
 168-346 4.23e-05

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 45.43  E-value: 4.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 168 LGQMSASFVHEFRNPLTSIMGFVKLLK--ADHPSLSYLDI------ISHELDQLNFRISQFLLVSKKEMWnESERFWLND 239
Cdd:PRK13557 163 LGQLTGGIAHDFNNLLQVMSGYLDVIQaaLSHPDADRGRMarsvenIRAAAERAATLTQQLLAFARKQRL-EGRVLNLNG 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 240 LFQDIIQFLYPSLvNANVLIEKNLP---YPIPLVGYRSEVrqVFLNILMNSIDAlesMKEERKIII-----DVFEEDQA- 310
Cdd:PRK13557 242 LVSGMGELAERTL-GDAVTIETDLApdlWNCRIDPTQAEV--ALLNVLINARDA---MPEGGRVTIrtrnvEIEDEDLAm 315

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446347231 311 ---------IRIVIKNNGPMIPAENVETIFEPFVTTKKLGTGIGL 346
Cdd:PRK13557 316 yhglppgryVSIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGL 360
PRK10604 PRK10604
sensor protein RstB; Provisional
 305-364 6.11e-05

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 44.59  E-value: 6.11e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446347231 305 FEEDQAIRIViKNNGPMIPAENVETIFEPFV------TTKKLGTGIGLFVCKQIVEKHNGSIMCRS 364
Cdd:PRK10604 345 LDGNQACLIV-EDDGPGIPPEERERVFEPFVrldpsrDRATGGCGLGLAIVHSIALAMGGSVNCDE 409
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 168-364 9.39e-05

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 44.45  E-value: 9.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 168 LGQMSasfvHEFRNPLTSIMGFVK-LLKAD-HPS-LSYLDIISHELDQLNFRISQFLLVSKKE---MWNESERFWLNDLF 241
Cdd:PRK11107 297 LANMS----HELRTPLNGVIGFTRqTLKTPlTPTqRDYLQTIERSANNLLAIINDILDFSKLEagkLVLENIPFSLRETL 372

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 242 QDIIQFLYPS-------LVnanVLIEKNLPYPipLVGYRSEVRQVFLNILMNSIdalesmK--EERKIIIDVFEEDQA-- 310
Cdd:PRK11107 373 DEVVTLLAHSahekgleLT---LNIDPDVPDN--VIGDPLRLQQIITNLVGNAI------KftESGNIDILVELRALSnt 441

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446347231 311 ---IRIVIKNNGPMIPAENVETIFEPF------VTTKKLGTGIGLFVCKQIVEKHNGSIMCRS 364
Cdd:PRK11107 442 kvqLEVQIRDTGIGISERQQSQLFQAFrqadasISRRHGGTGLGLVITQKLVNEMGGDISFHS 504
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 259-365 1.04e-04

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 44.16  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 259 IEKNLPYPIPLVGYRSEVRQVFLNILMNSidalesMK--EERKIIIDV-FEEDQAIRIVIKNNGPMIPAENVETIFEPFV 335
Cdd:PRK11091 382 LEPLLPLPHKVITDGTRLRQILWNLISNA------VKftQQGGVTVRVrYEEGDMLTFEVEDSGIGIPEDELDKIFAMYY 455

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446347231 336 TTKKL-------GTGIGLFVCKQIVEKHNGSIMCRSD 365
Cdd:PRK11091 456 QVKDShggkpatGTGIGLAVSKRLAQAMGGDITVTSE 492
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 248-360 1.82e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 38.00  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 248 LYPSLVNA--------NVLIEKNLPYPIPLVGYRSEVRQVFLNILMNSID-ALEsmkeerKIIIDVFEEDQAIRIVIKNN 318
Cdd:cd16954    2 LLDSLCSAlnkvyqrkGVSISLDISPELRFPGERNDLMELLGNLLDNACKwCLE------FVEVTARQTDGGLHLIVDDD 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446347231 319 GPMIPAENVETIFE--PFVTTKKLGTGIGLFVCKQIVEKHNGSI 360
Cdd:cd16954   76 GPGVPESQRSKIFQrgQRLDEQRPGQGLGLAIAKEIVEQYGGEL 119
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
173-360 4.22e-03

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 39.19  E-value: 4.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 173 ASFVHEFRNPLTSIMGFVKLLKA--------------DHPSLSYLDIISHELD-------QL-------------NFRIS 218
Cdd:PRK10841 452 ATVSHELRTPLYGIIGNLDLLQTkelpkgvdrlvtamNNSSSLLLKIISDILDfskieseQLkieprefspreviNHITA 531

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347231 219 QFL-LVSKKEMWneserfwlndlfqdiiqfLYpslvnanVLIEKNLPypIPLVGYRSEVRQVFLNILMNSIDALESmkee 297
Cdd:PRK10841 532 NYLpLVVKKRLG------------------LY-------CFIEPDVP--VALNGDPMRLQQVISNLLSNAIKFTDT---- 580

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446347231 298 RKIIIDVFEEDQAIRIVIKNNGPMIPAENVETIFEPF------VTTKKLGTGIGLFVCKQIVEKHNGSI 360
Cdd:PRK10841 581 GCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFfqvgtgVQRNFQGTGLGLAICEKLINMMDGDI 649
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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