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Conserved domains on  [gi|446353306|ref|WP_000431161|]
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MULTISPECIES: NAD(P)-dependent oxidoreductase [Bacillus]

Protein Classification

NAD(P)-dependent oxidoreductase( domain architecture ID 11449905)

NAD(P)-dependent oxidoreductase similar to 3-hydroxyisobutyrate dehydrogenase, L-threonate dehydrogenase, 2-(hydroxymethyl)glutarate dehydrogenase, and glyoxylate/succinic semialdehyde reductase

CATH:  3.40.50.720
EC:  1.1.-.-
Gene Ontology:  GO:0050661|GO:0051287|GO:0016491
PubMed:  8749365
SCOP:  4000072

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 8-289 2.01e-59

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


:

Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 191.10  E-value: 2.01e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306   8 PVTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGAVSASPLVIICVLDYNVVHEVL----GPV 83
Cdd:COG2084    3 KVGFIGLGAMGAPMARNLLKAGHEVTVWNRTPAKAEALVAAGARVAASPAEAAAAADVVITMLPDDAAVEEVLlgedGLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306  84 GDALKGRTLVNLTADSPKRAREMATWAAQHGVDYLDGAIMTPTPTIGTPAASVLYSGPESIFKVHQPTLASLGGTTSYLG 163
Cdd:COG2084   83 AALRPGAVVVDMSTISPETARELAAAAAARGVRYLDAPVSGGPAGAEAGTLTIMVGGDEAAFERARPVLEAMGKRIVHVG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306 164 aDPGRAAAYDVALLDLFWTSMSGYAHALALATAENIPAKEFaiyaqgiIDIL------PDIMAYLASEVDSGHY-PGDKS 236
Cdd:COG2084  163 -DAGAGQAAKLANNLLLAGTMAALAEALALAEKAGLDPETL-------LEVLsggaagSWVLENRGPRMLAGDFdPGFAL 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446353306 237 NIisASAGMEHIIHAAQHHGLDVSVLSAAMAVTQQAINEGYGTDGFSRLTELL 289
Cdd:COG2084  235 DL--MLKDLGLALEAARAAGVPLPLAAAARQLYARAVAAGHGDEDFSALIKLL 285
 
Name Accession Description Interval E-value
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 8-289 2.01e-59

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 191.10  E-value: 2.01e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306   8 PVTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGAVSASPLVIICVLDYNVVHEVL----GPV 83
Cdd:COG2084    3 KVGFIGLGAMGAPMARNLLKAGHEVTVWNRTPAKAEALVAAGARVAASPAEAAAAADVVITMLPDDAAVEEVLlgedGLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306  84 GDALKGRTLVNLTADSPKRAREMATWAAQHGVDYLDGAIMTPTPTIGTPAASVLYSGPESIFKVHQPTLASLGGTTSYLG 163
Cdd:COG2084   83 AALRPGAVVVDMSTISPETARELAAAAAARGVRYLDAPVSGGPAGAEAGTLTIMVGGDEAAFERARPVLEAMGKRIVHVG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306 164 aDPGRAAAYDVALLDLFWTSMSGYAHALALATAENIPAKEFaiyaqgiIDIL------PDIMAYLASEVDSGHY-PGDKS 236
Cdd:COG2084  163 -DAGAGQAAKLANNLLLAGTMAALAEALALAEKAGLDPETL-------LEVLsggaagSWVLENRGPRMLAGDFdPGFAL 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446353306 237 NIisASAGMEHIIHAAQHHGLDVSVLSAAMAVTQQAINEGYGTDGFSRLTELL 289
Cdd:COG2084  235 DL--MLKDLGLALEAARAAGVPLPLAAAARQLYARAVAAGHGDEDFSALIKLL 285
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 9-163 3.30e-19

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 82.52  E-value: 3.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306    9 VTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGAVSASPLVIICVLDYNVVHEVL--GPVGDA 86
Cdd:pfam03446   2 IGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEKVEELVAAGAIAAASPAEFVAGLDVVITMVPAGAAVDAVIfgEGLLPG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306   87 L-KGRTLVNLTADSPKRAREMATWAAQHGVDYLDgaimtpTPTIGTPAA------SVLYSGPESIFKVHQPTLASLGGTT 159
Cdd:pfam03446  82 LkPGDIIIDGSTSSPEDARRRAKELKEKGLHFLD------APVSGGEAGaengtlSIMVGGDEEAFERVKPILEAMGACV 155


                  ....
gi 446353306  160 SYLG 163
Cdd:pfam03446 156 TYIG 159
garR PRK11559
tartronate semialdehyde reductase; Provisional
 12-163 5.32e-13

tartronate semialdehyde reductase; Provisional


Pssm-ID: 183197 [Multi-domain]  Cd Length: 296  Bit Score: 67.77  E-value: 5.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306  12 IGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGAVSASPLVIICVLDYNVVHEV-LGPVG---DAL 87
Cdd:PRK11559   8 IGLGIMGKPMSKNLLKAGYSLVVYDRNPEAVAEVIAAGAETASTAKAVAEQCDVIITMLPNSPHVKEVaLGENGiieGAK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306  88 KGRTLVNLTADSPKRAREMATWAAQHGVDYLDGAImtptpTIGTPAA-----SVLYSGPESIFKVHQPTLASLGGTTSYL 162
Cdd:PRK11559  88 PGTVVIDMSSIAPLASREIAAALKAKGIEMLDAPV-----SGGEPKAidgtlSVMVGGDKAIFDKYYDLMKAMAGSVVHT 162


                 .
gi 446353306 163 G 163
Cdd:PRK11559 163 G 163
 
Name Accession Description Interval E-value
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 8-289 2.01e-59

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 191.10  E-value: 2.01e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306   8 PVTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGAVSASPLVIICVLDYNVVHEVL----GPV 83
Cdd:COG2084    3 KVGFIGLGAMGAPMARNLLKAGHEVTVWNRTPAKAEALVAAGARVAASPAEAAAAADVVITMLPDDAAVEEVLlgedGLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306  84 GDALKGRTLVNLTADSPKRAREMATWAAQHGVDYLDGAIMTPTPTIGTPAASVLYSGPESIFKVHQPTLASLGGTTSYLG 163
Cdd:COG2084   83 AALRPGAVVVDMSTISPETARELAAAAAARGVRYLDAPVSGGPAGAEAGTLTIMVGGDEAAFERARPVLEAMGKRIVHVG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306 164 aDPGRAAAYDVALLDLFWTSMSGYAHALALATAENIPAKEFaiyaqgiIDIL------PDIMAYLASEVDSGHY-PGDKS 236
Cdd:COG2084  163 -DAGAGQAAKLANNLLLAGTMAALAEALALAEKAGLDPETL-------LEVLsggaagSWVLENRGPRMLAGDFdPGFAL 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446353306 237 NIisASAGMEHIIHAAQHHGLDVSVLSAAMAVTQQAINEGYGTDGFSRLTELL 289
Cdd:COG2084  235 DL--MLKDLGLALEAARAAGVPLPLAAAARQLYARAVAAGHGDEDFSALIKLL 285
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 9-163 3.30e-19

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 82.52  E-value: 3.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306    9 VTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGAVSASPLVIICVLDYNVVHEVL--GPVGDA 86
Cdd:pfam03446   2 IGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEKVEELVAAGAIAAASPAEFVAGLDVVITMVPAGAAVDAVIfgEGLLPG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306   87 L-KGRTLVNLTADSPKRAREMATWAAQHGVDYLDgaimtpTPTIGTPAA------SVLYSGPESIFKVHQPTLASLGGTT 159
Cdd:pfam03446  82 LkPGDIIIDGSTSSPEDARRRAKELKEKGLHFLD------APVSGGEAGaengtlSIMVGGDEEAFERVKPILEAMGACV 155


                  ....
gi 446353306  160 SYLG 163
Cdd:pfam03446 156 TYIG 159
garR PRK11559
tartronate semialdehyde reductase; Provisional
 12-163 5.32e-13

tartronate semialdehyde reductase; Provisional


Pssm-ID: 183197 [Multi-domain]  Cd Length: 296  Bit Score: 67.77  E-value: 5.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306  12 IGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGAVSASPLVIICVLDYNVVHEV-LGPVG---DAL 87
Cdd:PRK11559   8 IGLGIMGKPMSKNLLKAGYSLVVYDRNPEAVAEVIAAGAETASTAKAVAEQCDVIITMLPNSPHVKEVaLGENGiieGAK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306  88 KGRTLVNLTADSPKRAREMATWAAQHGVDYLDGAImtptpTIGTPAA-----SVLYSGPESIFKVHQPTLASLGGTTSYL 162
Cdd:PRK11559  88 PGTVVIDMSSIAPLASREIAAALKAKGIEMLDAPV-----SGGEPKAidgtlSVMVGGDKAIFDKYYDLMKAMAGSVVHT 162


                 .
gi 446353306 163 G 163
Cdd:PRK11559 163 G 163
PRK15059 PRK15059
2-hydroxy-3-oxopropionate reductase;
12-165 6.00e-09

2-hydroxy-3-oxopropionate reductase;


Pssm-ID: 185019 [Multi-domain]  Cd Length: 292  Bit Score: 55.80  E-value: 6.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306  12 IGLGPMGQALAGAFLMNGHPTTLwNRTAEKADYLISQGATLSNSVTGAVSASPLVIICVLDYNVVHEVL----GPVGDAL 87
Cdd:PRK15059   6 IGLGIMGTPMAINLARAGHQLHV-TTIGPVADELLSLGAVSVETARQVTEASDIIFIMVPDTPQVEEVLfgenGCTKASL 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446353306  88 KGRTLVNLTADSPKRAREMATWAAQHGVDYLDGAIMTPTPTIGTPAASVLYSGPESIFKVHQPTLASLGGTTSYLGAD 165
Cdd:PRK15059  85 KGKTIVDMSSISPIETKRFARQVNELGGDYLDAPVSGGEIGAREGTLSIMVGGDEAVFERVKPLFELLGKNITLVGGN 162
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
9-93 3.33e-08

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 52.87  E-value: 3.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306   9 VTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQ-GATLS-NSVTGAVSASPLVIICVLdYNVVHEVLGPVGDA 86
Cdd:COG2085    1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPEKAAALAAElGPGARaGTNAEAAAAADVVVLAVP-YEAVPDVLESLGDA 79


                 ....*..
gi 446353306  87 LKGRTLV 93
Cdd:COG2085   80 LAGKIVI 86
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 9-93 1.72e-07

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 51.22  E-value: 1.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306   9 VTVIGLGPMGQALAGAFLMNGHPT---TLWNRTAEKADYLISQ-GATLSNSVTGAVSASPLVIICVLDYnVVHEVLGPVG 84
Cdd:COG0345    5 IGFIGAGNMGSAIIKGLLKSGVPPediIVSDRSPERLEALAERyGVRVTTDNAEAAAQADVVVLAVKPQ-DLAEVLEELA 83


                 ....*....
gi 446353306  85 DALKGRTLV 93
Cdd:COG0345   84 PLLDPDKLV 92
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 9-96 4.40e-05

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 44.26  E-value: 4.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306   9 VTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQ--------GATLSNSVT------GAVSASPLVIICVlDYN 74
Cdd:COG0240    3 IAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVAEEINETrenprylpGVKLPENLRatsdleEALAGADLVLLAV-PSQ 81

                         90       100
                 ....*....|....*....|...
gi 446353306  75 VVHEVLGPVGDAL-KGRTLVNLT 96
Cdd:COG0240   82 ALREVLEQLAPLLpPGAPVVSAT 104
PRK07680 PRK07680
late competence protein ComER; Validated
 9-83 1.14e-04

late competence protein ComER; Validated


Pssm-ID: 181080 [Multi-domain]  Cd Length: 273  Bit Score: 42.65  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306   9 VTVIGLGPMGQALAGAFLMNGHPT----TLWNRTAEKADYLISQ--GATLSNSVTGAVSASPLVIICV--LDYNVVHEVL 80
Cdd:PRK07680   3 IGFIGTGNMGTILIEAFLESGAVKpsqlTITNRTPAKAYHIKERypGIHVAKTIEEVISQSDLIFICVkpLDIYPLLQKL 82


                 ...
gi 446353306  81 GPV 83
Cdd:PRK07680  83 APH 85
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
11-97 2.31e-04

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 39.52  E-value: 2.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306   11 VIGLGPMGQALAGAFLMNG--HPTTLWNRTAEKADYL---ISQGATLSnSVTGAVSASPLVIICVlDYNVVHEVLGPVGD 85
Cdd:pfam03807   2 FIGAGNMGEALARGLVAAGphEVVVANSRNPEKAEELaeeYGVGATAV-DNEEAAEEADVVFLAV-KPEDAPDVLSELSD 79

                          90
                  ....*....|..
gi 446353306   86 ALKGRTLVNLTA 97
Cdd:pfam03807  80 LLKGKIVISIAA 91
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
9-107 5.00e-04

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 41.21  E-value: 5.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306   9 VTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKAD----------YLisQGATLSNSVT------GAVSASPLVIICVLD 72
Cdd:PRK00094   4 IAVLGAGSWGTALAIVLARNGHDVTLWARDPEQAAeinadrenprYL--PGIKLPDNLRattdlaEALADADLILVAVPS 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446353306  73 YnVVHEVLGPVGDALK-GRTLVNLT----ADSPKRAREMA 107
Cdd:PRK00094  82 Q-ALREVLKQLKPLLPpDAPIVWATkgiePGTGKLLSEVL 120
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 9-43 9.23e-04

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 40.09  E-value: 9.23e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 446353306   9 VTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKAD 43
Cdd:COG1250    5 VAVIGAGTMGAGIAAVFANAGYEVVLLDISPEALE 39
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-66 1.22e-03

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 39.97  E-value: 1.22e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446353306   1 MENPHRspVTVIGLGPMGQALAGAFLMNGHPTTLWNRtaekadyliSQGATLSNSVTGA---VSASPLV 66
Cdd:PRK14619   1 TTQPKT--IAILGAGAWGSTLAGLASANGHRVRVWSR---------RSGLSLAAVLADAdviVSAVSMK 58
COG5495 COG5495
Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains ...
 9-72 1.60e-03

Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains [General function prediction only];


Pssm-ID: 444246 [Multi-domain]  Cd Length: 286  Bit Score: 39.41  E-value: 1.60e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446353306   9 VTVIGLGPMGQALAGAFLMNGHP-TTLWNRTAEKADYLISQ-GATLSNSVTGAVSASPLVIICVLD 72
Cdd:COG5495    6 IGIIGAGRVGTALAAALRAAGHEvVGVYSRSPASAERAAALlGAVPALDLEELAAEADLVLLAVPD 71
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 8-96 1.92e-03

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 37.94  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306    8 PVTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKAD----------YL----ISQGATLSNSVTGAVSASPLVIIcVLDY 73
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADNGHEVRLWGRDEELIEeintthenvrYLpgikLPENLKATTDLAEALKGADIIVI-VVPS 79

                          90       100
                  ....*....|....*....|....
gi 446353306   74 NVVHEVLGPVGDALKGRT-LVNLT 96
Cdd:pfam01210  80 QALREVLKQLKGLLKPDAiLVSLS 103
ApbA pfam02558
Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also ...
 9-93 1.99e-03

Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases, EC:1.1.1.169. The reaction catalyzed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH. AbpA catalyzes the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway. ApbA and PanE are allelic. ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway.


Pssm-ID: 426831 [Multi-domain]  Cd Length: 147  Bit Score: 37.98  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306    9 VTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADY------LISQGATLSNSVTGAVSASP------LVIICVLDYNVV 76
Cdd:pfam02558   1 IAILGAGAIGSLLGARLAKAGHDVTLILRGAELAAIkknglrLTSPGGERIVPPPAVTSASEslgpidLVIVTVKAYQTE 80

                          90
                  ....*....|....*..
gi 446353306   77 hEVLGPVGDALKGRTLV 93
Cdd:pfam02558  81 -EALEDIAPLLGPNTVV 96
PRK15461 PRK15461
sulfolactaldehyde 3-reductase;
12-80 3.44e-03

sulfolactaldehyde 3-reductase;


Pssm-ID: 185358 [Multi-domain]  Cd Length: 296  Bit Score: 38.30  E-value: 3.44e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446353306  12 IGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQGATLSNSVTGAVSASPLVIICVLDYNVVHEVL 80
Cdd:PRK15461   7 IGLGQMGSPMASNLLKQGHQLQVFDVNPQAVDALVDKGATPAASPAQAAAGAEFVITMLPNGDLVRSVL 75
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 3-177 7.24e-03

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 37.54  E-value: 7.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306   3 NPHRSPVTVIGLGPMGQALAGAFLMNGHPTTLWNRTAEKADYLISQ--------GATLSNSVtgAVSASPLVIICVLDYN 74
Cdd:PRK14618   1 MHHGMRVAVLGAGAWGTALAVLAASKGVPVRLWARRPEFAAALAAErenreylpGVALPAEL--YPTADPEEALAGADFA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306  75 VVhevlgpvgdALKGRTLVNLTADSPkraREMATWAAQHGVDYLDGAIMTPTPTIG--TPAASVLYSGPESIFKVHQptl 152
Cdd:PRK14618  79 VV---------AVPSKALRETLAGLP---RALGYVSCAKGLAPDGGRLSELARVLEflTQARVAVLSGPNHAEEIAR--- 143

                        170       180
                 ....*....|....*....|....*
gi 446353306 153 aSLGGTTSYLGADPGRAAAYDVALL 177
Cdd:PRK14618 144 -FLPAATVVASPEPGLARRVQAAFS 167
Sacchrp_dh_NADP pfam03435
Saccharopine dehydrogenase NADP binding domain; This family contains the NADP binding domain ...
 9-127 9.90e-03

Saccharopine dehydrogenase NADP binding domain; This family contains the NADP binding domain of saccharopine dehydrogenase. In some organizms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase. The saccharopine dehydrogenase can also function as a saccharopine reductase.


Pssm-ID: 397480 [Multi-domain]  Cd Length: 120  Bit Score: 35.26  E-value: 9.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353306    9 VTVIGLGPMGQALAGAFLMNGHPT--TLWNRTAEKADYLISQgatlsnsvtgavSASPLVIICVLDYNVVHEVLGPvgdA 86
Cdd:pfam03435   1 VLIIGAGSVGQGVAPLLARHFDVDriTVADRTLEKAQALAAK------------LGGVRFIAVAVDADNYEAVLAA---L 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 446353306   87 LKGRTLV-NLTadSPKRAREMATWAAQHGVDYLDGAIMTPTP 127
Cdd:pfam03435  66 LKEGDLVvNLS--PPTLSLDVLKACIETGVHYVDTSYLREAV 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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