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Conserved domains on  [gi|446353379|ref|WP_000431234|]
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MULTISPECIES: O-antigen ligase [Staphylococcus]

Protein Classification

O-antigen ligase family protein( domain architecture ID 11462199)

O-antigen ligase family protein may be involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane of gram-negative bacteria; similar to Escherichia coli O-antigen ligase RfaL, which adds the O-antigen on the glucose group of lipopolysaccharide

PubMed:  17890310

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RfaL COG3307
O-antigen ligase [Cell wall/membrane/envelope biogenesis];
162-400 5.94e-11

O-antigen ligase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442536 [Multi-domain]  Cd Length: 239  Bit Score: 62.02  E-value: 5.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353379 162 MNDPNYFA--MTQIITLVLAYKYIHN-----YIFKVLACGILLWSLTTTGSKTAFIILIV--LAIYFFIKKLFSRNAVSV 232
Cdd:COG3307    2 FGNPNHLAayLALALPLLLALLLLLKrrrlrRLLALLALLLALLALLLTGSRGAWLALLVglLLLLLLYKRKLRLRRLLL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353379 233 VSMSVIMLILLCFTFYninyylfqlsdldALPSLDRMASIFEEgfaslNDSGSERSVVWINAISVIKYTLGFGVGLVDYV 312
Cdd:COG3307   82 LLLAALLLLLLALILV-------------SPPLAERLLEILGK-----DSSLGGRLEIWKAALEMIKEHPLLGVGYGNFW 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353379 313 HIGSQ-----INGILLVAHNTYLQIFAEWGILFGALFIIFMLYLLFELFR-FNISGKNVTAIVVMLTMLIYFLTVSFNNS 386
Cdd:COG3307  144 YAYPAyqpagYIWNAGHAHNEYLEILAETGILGLLLLLLLLLVLLRRALRrLRRSRLALALLALLLALLVHGLTESPLFS 223
                        250
                 ....*....|....
gi 446353379 387 RYVAFILGIIVFIV 400
Cdd:COG3307  224 PASALLFWLLLALL 237
 
Name Accession Description Interval E-value
RfaL COG3307
O-antigen ligase [Cell wall/membrane/envelope biogenesis];
162-400 5.94e-11

O-antigen ligase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442536 [Multi-domain]  Cd Length: 239  Bit Score: 62.02  E-value: 5.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353379 162 MNDPNYFA--MTQIITLVLAYKYIHN-----YIFKVLACGILLWSLTTTGSKTAFIILIV--LAIYFFIKKLFSRNAVSV 232
Cdd:COG3307    2 FGNPNHLAayLALALPLLLALLLLLKrrrlrRLLALLALLLALLALLLTGSRGAWLALLVglLLLLLLYKRKLRLRRLLL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353379 233 VSMSVIMLILLCFTFYninyylfqlsdldALPSLDRMASIFEEgfaslNDSGSERSVVWINAISVIKYTLGFGVGLVDYV 312
Cdd:COG3307   82 LLLAALLLLLLALILV-------------SPPLAERLLEILGK-----DSSLGGRLEIWKAALEMIKEHPLLGVGYGNFW 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353379 313 HIGSQ-----INGILLVAHNTYLQIFAEWGILFGALFIIFMLYLLFELFR-FNISGKNVTAIVVMLTMLIYFLTVSFNNS 386
Cdd:COG3307  144 YAYPAyqpagYIWNAGHAHNEYLEILAETGILGLLLLLLLLLVLLRRALRrLRRSRLALALLALLLALLVHGLTESPLFS 223
                        250
                 ....*....|....
gi 446353379 387 RYVAFILGIIVFIV 400
Cdd:COG3307  224 PASALLFWLLLALL 237
Wzy_C pfam04932
O-Antigen ligase; This group of bacterial proteins is involved in the synthesis of O-antigen, ...
191-345 2.48e-04

O-Antigen ligase; This group of bacterial proteins is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in gram-negative bacteria. This family includes O-antigen ligases such as E. coli RfaL.


Pssm-ID: 461489  Cd Length: 148  Bit Score: 41.23  E-value: 2.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353379  191 LACGILLWSLTTTGSKTAFIILIVLAIYFFIKKLFSRNAVSVVSMsVIMLILLCFTFYNINYYLFQLSDLdalpsldrma 270
Cdd:pfam04932   1 LALVLLLLALVLTGSRGALLALLVALLLLLLLYLRRRLRRRLLAL-VLLGVLLLFALLFLADGLFTLGRL---------- 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353379  271 sifEEGFASLNDSGSERSVVWINAISVIKYTLGFGVGLVDYVHIGSQINGILLV-------AHNTYLQIFAEWGILFGAL 343
Cdd:pfam04932  70 ---VSALQAKDGSSSGRLEIWKSALDLIKDHPLLGVGAGTGLAYAAYLLYAQLLgsggythAHNLYLEILAELGIPGLLL 146

                  ..
gi 446353379  344 FI 345
Cdd:pfam04932 147 FL 148
 
Name Accession Description Interval E-value
RfaL COG3307
O-antigen ligase [Cell wall/membrane/envelope biogenesis];
162-400 5.94e-11

O-antigen ligase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442536 [Multi-domain]  Cd Length: 239  Bit Score: 62.02  E-value: 5.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353379 162 MNDPNYFA--MTQIITLVLAYKYIHN-----YIFKVLACGILLWSLTTTGSKTAFIILIV--LAIYFFIKKLFSRNAVSV 232
Cdd:COG3307    2 FGNPNHLAayLALALPLLLALLLLLKrrrlrRLLALLALLLALLALLLTGSRGAWLALLVglLLLLLLYKRKLRLRRLLL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353379 233 VSMSVIMLILLCFTFYninyylfqlsdldALPSLDRMASIFEEgfaslNDSGSERSVVWINAISVIKYTLGFGVGLVDYV 312
Cdd:COG3307   82 LLLAALLLLLLALILV-------------SPPLAERLLEILGK-----DSSLGGRLEIWKAALEMIKEHPLLGVGYGNFW 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353379 313 HIGSQ-----INGILLVAHNTYLQIFAEWGILFGALFIIFMLYLLFELFR-FNISGKNVTAIVVMLTMLIYFLTVSFNNS 386
Cdd:COG3307  144 YAYPAyqpagYIWNAGHAHNEYLEILAETGILGLLLLLLLLLVLLRRALRrLRRSRLALALLALLLALLVHGLTESPLFS 223
                        250
                 ....*....|....
gi 446353379 387 RYVAFILGIIVFIV 400
Cdd:COG3307  224 PASALLFWLLLALL 237
Wzy_C pfam04932
O-Antigen ligase; This group of bacterial proteins is involved in the synthesis of O-antigen, ...
191-345 2.48e-04

O-Antigen ligase; This group of bacterial proteins is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in gram-negative bacteria. This family includes O-antigen ligases such as E. coli RfaL.


Pssm-ID: 461489  Cd Length: 148  Bit Score: 41.23  E-value: 2.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353379  191 LACGILLWSLTTTGSKTAFIILIVLAIYFFIKKLFSRNAVSVVSMsVIMLILLCFTFYNINYYLFQLSDLdalpsldrma 270
Cdd:pfam04932   1 LALVLLLLALVLTGSRGALLALLVALLLLLLLYLRRRLRRRLLAL-VLLGVLLLFALLFLADGLFTLGRL---------- 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446353379  271 sifEEGFASLNDSGSERSVVWINAISVIKYTLGFGVGLVDYVHIGSQINGILLV-------AHNTYLQIFAEWGILFGAL 343
Cdd:pfam04932  70 ---VSALQAKDGSSSGRLEIWKSALDLIKDHPLLGVGAGTGLAYAAYLLYAQLLgsggythAHNLYLEILAELGIPGLLL 146

                  ..
gi 446353379  344 FI 345
Cdd:pfam04932 147 FL 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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