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Conserved domains on  [gi|446355683|ref|WP_000433538|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Bacillus]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-103 1.95e-18

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 73.00  E-value: 1.95e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446355683   6 IYKALSNETRCQILSWLKNPEnhfdekayleqglsfqvgVCVGDIQLKTGLAQSVISSYLLTMKKAGLLQSDRIGKWTYY 85
Cdd:COG0640   13 LFKALADPTRLRILRLLAEGE------------------LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYY 74

                         90
                 ....*....|....*...
gi 446355683  86 RRNEKTIREFSEYVQNEL 103
Cdd:COG0640   75 RLADEALAELLEWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-103 1.95e-18

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 73.00  E-value: 1.95e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446355683   6 IYKALSNETRCQILSWLKNPEnhfdekayleqglsfqvgVCVGDIQLKTGLAQSVISSYLLTMKKAGLLQSDRIGKWTYY 85
Cdd:COG0640   13 LFKALADPTRLRILRLLAEGE------------------LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYY 74

                         90
                 ....*....|....*...
gi 446355683  86 RRNEKTIREFSEYVQNEL 103
Cdd:COG0640   75 RLADEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 6-94 4.91e-12

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 56.31  E-value: 4.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446355683   6 IYKALSNETRCQILSWLKNPEnhfdekayleqglsfqvgVCVGDIQLKTGLAQSVISSYLLTMKKAGLLQSDRIGKWTYY 85
Cdd:NF033788   4 LFKALADPTRLRILELLAEGE------------------LCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYY 65


                 ....*....
gi 446355683  86 RRNEKTIRE 94
Cdd:NF033788  66 RLADEHVAE 74
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 8-90 8.64e-10

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 50.76  E-value: 8.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446355683   8 KALSNETRCQILswlknpenhfdekAYLEQGlsfqvGVCVGDIQLKTGLAQSVISSYLLTMKKAGLLQSDRIGKWTYYRR 87
Cdd:cd00090    2 KALSDPTRLRIL-------------RLLLEG-----PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSL 63


                 ...
gi 446355683  88 NEK 90
Cdd:cd00090   64 TDA 66
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
46-95 1.36e-08

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 47.21  E-value: 1.36e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 446355683    46 CVGDIQLKTGLAQSVISSYLLTMKKAGLLQSDRIGKWTYYRRNEKTIREF 95
Cdd:smart00418  12 CVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADL 61
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 1-86 9.10e-07

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 43.65  E-value: 9.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446355683   1 MEPLLIYKALSNETRCQILSWLKnpenhfdekaylEQGlsfqvGVCVGDIQLKTGLAQSVISSYLLTMKKAGLLQSDRIG 80
Cdd:PRK10141   4 LLPLQLFKILSDETRLGIVLLLR------------ESG-----ELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQG 66


                 ....*.
gi 446355683  81 KWTYYR 86
Cdd:PRK10141  67 KWVHYR 72
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-103 1.95e-18

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 73.00  E-value: 1.95e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446355683   6 IYKALSNETRCQILSWLKNPEnhfdekayleqglsfqvgVCVGDIQLKTGLAQSVISSYLLTMKKAGLLQSDRIGKWTYY 85
Cdd:COG0640   13 LFKALADPTRLRILRLLAEGE------------------LCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYY 74

                         90
                 ....*....|....*...
gi 446355683  86 RRNEKTIREFSEYVQNEL 103
Cdd:COG0640   75 RLADEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 6-94 4.91e-12

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 56.31  E-value: 4.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446355683   6 IYKALSNETRCQILSWLKNPEnhfdekayleqglsfqvgVCVGDIQLKTGLAQSVISSYLLTMKKAGLLQSDRIGKWTYY 85
Cdd:NF033788   4 LFKALADPTRLRILELLAEGE------------------LCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYY 65


                 ....*....
gi 446355683  86 RRNEKTIRE 94
Cdd:NF033788  66 RLADEHVAE 74
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 8-90 8.64e-10

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 50.76  E-value: 8.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446355683   8 KALSNETRCQILswlknpenhfdekAYLEQGlsfqvGVCVGDIQLKTGLAQSVISSYLLTMKKAGLLQSDRIGKWTYYRR 87
Cdd:cd00090    2 KALSDPTRLRIL-------------RLLLEG-----PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSL 63


                 ...
gi 446355683  88 NEK 90
Cdd:cd00090   64 TDA 66
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
46-95 1.36e-08

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 47.21  E-value: 1.36e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 446355683    46 CVGDIQLKTGLAQSVISSYLLTMKKAGLLQSDRIGKWTYYRRNEKTIREF 95
Cdd:smart00418  12 CVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADL 61
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 1-86 9.10e-07

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 43.65  E-value: 9.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446355683   1 MEPLLIYKALSNETRCQILSWLKnpenhfdekaylEQGlsfqvGVCVGDIQLKTGLAQSVISSYLLTMKKAGLLQSDRIG 80
Cdd:PRK10141   4 LLPLQLFKILSDETRLGIVLLLR------------ESG-----ELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQG 66


                 ....*.
gi 446355683  81 KWTYYR 86
Cdd:PRK10141  67 KWVHYR 72
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
6-76 2.71e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 36.86  E-value: 2.71e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446355683   6 IYKALSNETRCQILSWLknpenhfdekayLEQGLSfqvgvcVGDIQLKTGLAQSVISSYLLTMKKAGLLQS 76
Cdd:COG4189   12 VLKALASETRLRILRLL------------AEEPLN------VNELAEALGLPKSTVSYHIRKLEEAGLIRT 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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