NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446358922|ref|WP_000436777|]
View 

MULTISPECIES: proline dehydrogenase family protein [Bacillus]

Protein Classification

bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase; bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase; proline dehydrogenase family protein; proline dehydrogenase family protein( domain architecture ID 11423475)

bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase catalyzes the two-step oxidation of proline to glutamate; bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase catalyzes the two-step oxidation of proline to glutamate; proline dehydrogenase family protein similar to Pectobacterium carotovorum carbapenem antibiotics biosynthesis protein CarD; proline dehydrogenase family protein similar to Pectobacterium carotovorum carbapenem antibiotics biosynthesis protein CarD; proline dehydrogenase family protein similar to Pectobacterium carotovorum carbapenem antibiotics biosynthesis protein CarD; proline dehydrogenase family protein similar to human mitochondrial proline dehydrogenase 1 that converts proline to delta-1-pyrroline-5-carboxylate; proline dehydrogenase family protein similar to Pectobacterium carotovorum carbapenem antibiotics biosynthesis protein CarD; proline dehydrogenase family protein similar to human mitochondrial proline dehydrogenase 1 that converts proline to delta-1-pyrroline-5-carboxylate; proline dehydrogenase family protein similar to human mitochondrial proline dehydrogenase 1 that converts proline to delta-1-pyrroline-5-carboxylate

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PutA super family cl33919
Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of ...
 27-277 3.84e-94

Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of the Pathway/BioSystem: Proline degradation


The actual alignment was detected with superfamily member COG0506:

Pssm-ID: 440272 [Multi-domain]  Cd Length: 975  Bit Score: 298.88  E-value: 3.84e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922  27 LRFGAGRFVAGETIELATAAIKQLNKQGLCVTIDYLGEFVDNEAEANEMASESIEAIRAIGREGL-NSQLSLKMTSMGLD 105
Cdd:COG0506  109 MRRMARRFVAGETIEEALKAARKLRAKGYRVSLDLLGEAVLTEAEAERYLDAYLEALEAIGAAGVdRPGVSVKLSALGPR 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922 106 ISD-------EIVMNNMRRILEAGKENGVFITIDMEDYTRCGKTIEIFKQLKSE-----YDNIGTVIQAYLYRTEKDMEE 173
Cdd:COG0506  189 YSPaqrervvEELLERLRPLARAAREAGIFVTIDMEEYDRLDLTLDVFERLLADpelagWPGVGIVLQAYLKRAEADLDR 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922 174 LNA------YSPNLRLVKGAYKEPEDV----------AFPDKKDVDDNYKKIIKMHLLNGN--YTAIASHDEAIIEYTKK 235
Cdd:COG0506  269 LAAlarrggRRIRVRLVKGAYWDPEIVraqvhgwpypVFTRKADTDANYLRCARKLLEAGDaiYPQFATHNARTIAAALA 348

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 446358922 236 LAEEHNIPRDQFEFQMLYGIRNERQLELVKE-GYKMRVYVPYG 277
Cdd:COG0506  349 LAGERGRPPDRFEFQMLYGMGEDLQRALAAVdGGRLLLYCPVV 391
 
Name Accession Description Interval E-value
PutA COG0506
Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of ...
 27-277 3.84e-94

Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of the Pathway/BioSystem: Proline degradation


Pssm-ID: 440272 [Multi-domain]  Cd Length: 975  Bit Score: 298.88  E-value: 3.84e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922  27 LRFGAGRFVAGETIELATAAIKQLNKQGLCVTIDYLGEFVDNEAEANEMASESIEAIRAIGREGL-NSQLSLKMTSMGLD 105
Cdd:COG0506  109 MRRMARRFVAGETIEEALKAARKLRAKGYRVSLDLLGEAVLTEAEAERYLDAYLEALEAIGAAGVdRPGVSVKLSALGPR 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922 106 ISD-------EIVMNNMRRILEAGKENGVFITIDMEDYTRCGKTIEIFKQLKSE-----YDNIGTVIQAYLYRTEKDMEE 173
Cdd:COG0506  189 YSPaqrervvEELLERLRPLARAAREAGIFVTIDMEEYDRLDLTLDVFERLLADpelagWPGVGIVLQAYLKRAEADLDR 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922 174 LNA------YSPNLRLVKGAYKEPEDV----------AFPDKKDVDDNYKKIIKMHLLNGN--YTAIASHDEAIIEYTKK 235
Cdd:COG0506  269 LAAlarrggRRIRVRLVKGAYWDPEIVraqvhgwpypVFTRKADTDANYLRCARKLLEAGDaiYPQFATHNARTIAAALA 348

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 446358922 236 LAEEHNIPRDQFEFQMLYGIRNERQLELVKE-GYKMRVYVPYG 277
Cdd:COG0506  349 LAGERGRPPDRFEFQMLYGMGEDLQRALAAVdGGRLLLYCPVV 391
Pro_dh pfam01619
Proline dehydrogenase;
43-298 1.75e-54

Proline dehydrogenase;


Pssm-ID: 426348 [Multi-domain]  Cd Length: 296  Bit Score: 178.84  E-value: 1.75e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922   43 ATAAIKQLNKQGLCVTIDYLGEFVDNEAEANEMASESIEAIRAIGRE------GLNSQLSLKMTSMG--LDISD-----E 109
Cdd:pfam01619   1 ALKTIEKLRKQGYRFSLDMLGEAALTEADADRYLDAYLRAIDALGKAagpwplGPRPGISVKLSALHprYEPLErervmA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922  110 IVMNNMRRILEAGKENGVFITIDMEDYTRCGKTIEIFKQLKSE-----YDNIGTVIQAYLYRTEKDMEELNA------YS 178
Cdd:pfam01619  81 ELLERLRPLCRLAKELGVRLNIDAEEADRLDLTLDLFERLLAEpelrgWNGVGITLQAYLKDALAVLDWLLElarrrgRP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922  179 PNLRLVKGAY--KEPEDVA--------FPDKKDVDDNYKKIIKMhLLNGN---YTAIASHDEAIIEYTKKLAEEHNIPRD 245
Cdd:pfam01619 161 LGVRLVKGAYwdSEIKRAQqggwpypvFTRKEATDANYEACARF-LLENHdriYPQFATHNARSVAAALALAEELGIPPR 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 446358922  246 QFEFQMLYGIRNERQLELVKEGYKMRVYVPYG--NDWYGYFMRRLAERPANVAFV 298
Cdd:pfam01619 240 RFEFQQLYGMGDNLSFALVAAGYRVRKYAPVGphEELLAYLVRRLLENTANSSFV 294
PRK11904 PRK11904
bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA;
17-298 5.96e-13

bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA;


Pssm-ID: 237017 [Multi-domain]  Cd Length: 1038  Bit Score: 69.07  E-value: 5.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922   17 ALTKLAKKYG---LRFGAGR--------FVAGETIELATAAIKQLNKQGLCVTIDYLGEFVDNEAEANEMASESIEAIRA 85
Cdd:PRK11904  152 VLKRLVNRLGepvIRKAMRQamkimgkqFVLGRTIEEALKRARSARNKGYRYSFDMLGEAALTAADAERYFKAYARAIEA 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922   86 IGREGLNSQL------SLKMTSmgLD-----ISDEIVMNNM----RRILEAGKENGVFITIDMEDYTRCGKTIEIFKQLK 150
Cdd:PRK11904  232 IGRAAGGADLparpgiSIKLSA--LHpryeaAQRERVLAELvprvLELARLAKEANIGLTIDAEEADRLELSLDLFEALF 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922  151 SE-----YDNIGTVIQAYLYRTEKDMEELNAYS-------PnLRLVKGAY-----KEPEDVAFPD------KKDVDDNY- 206
Cdd:PRK11904  310 RDpslkgWGGFGLAVQAYQKRALPVLDWLADLArrqgrriP-VRLVKGAYwdseiKRAQELGLPGypvftrKAATDVSYl 388

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922  207 ---KKIIKM--HLlngnYTAIASHD----EAIIEytkkLAEEHNiprdqFEFQMLYGIRNErqL-ELVKEGYKM--RVYV 274
Cdd:PRK11904  389 acaRKLLSArgAI----YPQFATHNahtvAAILE----MAGHRG-----FEFQRLHGMGEA--LyDALLDAPGIpcRIYA 453

                         330       340
                  ....*....|....*....|....*.
gi 446358922  275 PYG--NDWYGYFMRRLAERPANVAFV 298
Cdd:PRK11904  454 PVGshKDLLPYLVRRLLENGANSSFV 479
 
Name Accession Description Interval E-value
PutA COG0506
Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of ...
 27-277 3.84e-94

Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of the Pathway/BioSystem: Proline degradation


Pssm-ID: 440272 [Multi-domain]  Cd Length: 975  Bit Score: 298.88  E-value: 3.84e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922  27 LRFGAGRFVAGETIELATAAIKQLNKQGLCVTIDYLGEFVDNEAEANEMASESIEAIRAIGREGL-NSQLSLKMTSMGLD 105
Cdd:COG0506  109 MRRMARRFVAGETIEEALKAARKLRAKGYRVSLDLLGEAVLTEAEAERYLDAYLEALEAIGAAGVdRPGVSVKLSALGPR 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922 106 ISD-------EIVMNNMRRILEAGKENGVFITIDMEDYTRCGKTIEIFKQLKSE-----YDNIGTVIQAYLYRTEKDMEE 173
Cdd:COG0506  189 YSPaqrervvEELLERLRPLARAAREAGIFVTIDMEEYDRLDLTLDVFERLLADpelagWPGVGIVLQAYLKRAEADLDR 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922 174 LNA------YSPNLRLVKGAYKEPEDV----------AFPDKKDVDDNYKKIIKMHLLNGN--YTAIASHDEAIIEYTKK 235
Cdd:COG0506  269 LAAlarrggRRIRVRLVKGAYWDPEIVraqvhgwpypVFTRKADTDANYLRCARKLLEAGDaiYPQFATHNARTIAAALA 348

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 446358922 236 LAEEHNIPRDQFEFQMLYGIRNERQLELVKE-GYKMRVYVPYG 277
Cdd:COG0506  349 LAGERGRPPDRFEFQMLYGMGEDLQRALAAVdGGRLLLYCPVV 391
Pro_dh pfam01619
Proline dehydrogenase;
43-298 1.75e-54

Proline dehydrogenase;


Pssm-ID: 426348 [Multi-domain]  Cd Length: 296  Bit Score: 178.84  E-value: 1.75e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922   43 ATAAIKQLNKQGLCVTIDYLGEFVDNEAEANEMASESIEAIRAIGRE------GLNSQLSLKMTSMG--LDISD-----E 109
Cdd:pfam01619   1 ALKTIEKLRKQGYRFSLDMLGEAALTEADADRYLDAYLRAIDALGKAagpwplGPRPGISVKLSALHprYEPLErervmA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922  110 IVMNNMRRILEAGKENGVFITIDMEDYTRCGKTIEIFKQLKSE-----YDNIGTVIQAYLYRTEKDMEELNA------YS 178
Cdd:pfam01619  81 ELLERLRPLCRLAKELGVRLNIDAEEADRLDLTLDLFERLLAEpelrgWNGVGITLQAYLKDALAVLDWLLElarrrgRP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922  179 PNLRLVKGAY--KEPEDVA--------FPDKKDVDDNYKKIIKMhLLNGN---YTAIASHDEAIIEYTKKLAEEHNIPRD 245
Cdd:pfam01619 161 LGVRLVKGAYwdSEIKRAQqggwpypvFTRKEATDANYEACARF-LLENHdriYPQFATHNARSVAAALALAEELGIPPR 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 446358922  246 QFEFQMLYGIRNERQLELVKEGYKMRVYVPYG--NDWYGYFMRRLAERPANVAFV 298
Cdd:pfam01619 240 RFEFQQLYGMGDNLSFALVAAGYRVRKYAPVGphEELLAYLVRRLLENTANSSFV 294
PRK11904 PRK11904
bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA;
17-298 5.96e-13

bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA;


Pssm-ID: 237017 [Multi-domain]  Cd Length: 1038  Bit Score: 69.07  E-value: 5.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922   17 ALTKLAKKYG---LRFGAGR--------FVAGETIELATAAIKQLNKQGLCVTIDYLGEFVDNEAEANEMASESIEAIRA 85
Cdd:PRK11904  152 VLKRLVNRLGepvIRKAMRQamkimgkqFVLGRTIEEALKRARSARNKGYRYSFDMLGEAALTAADAERYFKAYARAIEA 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922   86 IGREGLNSQL------SLKMTSmgLD-----ISDEIVMNNM----RRILEAGKENGVFITIDMEDYTRCGKTIEIFKQLK 150
Cdd:PRK11904  232 IGRAAGGADLparpgiSIKLSA--LHpryeaAQRERVLAELvprvLELARLAKEANIGLTIDAEEADRLELSLDLFEALF 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922  151 SE-----YDNIGTVIQAYLYRTEKDMEELNAYS-------PnLRLVKGAY-----KEPEDVAFPD------KKDVDDNY- 206
Cdd:PRK11904  310 RDpslkgWGGFGLAVQAYQKRALPVLDWLADLArrqgrriP-VRLVKGAYwdseiKRAQELGLPGypvftrKAATDVSYl 388

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922  207 ---KKIIKM--HLlngnYTAIASHD----EAIIEytkkLAEEHNiprdqFEFQMLYGIRNErqL-ELVKEGYKM--RVYV 274
Cdd:PRK11904  389 acaRKLLSArgAI----YPQFATHNahtvAAILE----MAGHRG-----FEFQRLHGMGEA--LyDALLDAPGIpcRIYA 453

                         330       340
                  ....*....|....*....|....*.
gi 446358922  275 PYG--NDWYGYFMRRLAERPANVAFV 298
Cdd:PRK11904  454 PVGshKDLLPYLVRRLLENGANSSFV 479
PRK11905 PRK11905
bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed
 13-298 1.37e-12

bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed


Pssm-ID: 237018 [Multi-domain]  Cd Length: 1208  Bit Score: 68.35  E-value: 1.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922   13 SKNKALTKLAKKYG---LRFGAGR--------FVAGETIELATAAIKQLNKQGLCVTIDYLGEFVDNEAEANEMASESIE 81
Cdd:PRK11905  147 GLSAALTRLIARLGepvIRKAVDMamrmmgeqFVTGETIEEALKRARELEARGYRYSYDMLGEAARTAADAERYYRDYER 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922   82 AIRAIGReglnsqlslkmTSMGLDISD--------------------EIVMNNM----RRILEAGKENGVFITIDMEDYT 137
Cdd:PRK11905  227 AIHAIGK-----------AATGRGVYDgpgisvklsalhpryeraqrERVMAELlprlKALALLAKAYDIGLNIDAEEAD 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922  138 RCGKTIEIFKQLKSE-----YDNIGTVIQAYLYRTEK------DMEELNAYSPNLRLVKGAYKEPE----DVA----FP- 197
Cdd:PRK11905  296 RLELSLDLLEALCSDpdlagWNGIGFVVQAYQKRCPFvidyliDLARRSGRRLMVRLVKGAYWDAEikraQVDglegFPv 375

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922  198 --DKKDVDDNY----KKIIKMHllNGNYTAIASHD----EAIIEytkkLAEehniPRDQFEFQMLYGIrNERQLELV--- 264
Cdd:PRK11905  376 ftRKVHTDVSYiacaRKLLAAR--DVIYPQFATHNaqtlAAIYE----LAG----GKGDFEFQCLHGM-GEPLYDQVvgk 444

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 446358922  265 -KEGYKMRVYVPYGN--DWYGYFMRRLAERPANVAFV 298
Cdd:PRK11905  445 eKLGRPCRIYAPVGTheTLLAYLVRRLLENGANSSFV 481
putA PRK11809
trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate ...
 16-298 7.15e-07

trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed


Pssm-ID: 236989 [Multi-domain]  Cd Length: 1318  Bit Score: 50.74  E-value: 7.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922   16 KALTKLAKKYG---LRFG---AGR-----FVAGETIELATAAIKQLNKQGLCVTIDYLGEFVDNEAEANE-MASESiEAI 83
Cdd:PRK11809  230 SSLNRIIGKSGeplIRKGvdmAMRlmgeqFVTGETIAEALANARKLEEKGFRYSYDMLGEAALTEADAQAyLASYE-QAI 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922   84 RAIGR--------EGlnSQLSLKMTSMGLDISD---EIVMNNM----RRILEAGKENGVFITIDMEDYTRCGKTIEIFKQ 148
Cdd:PRK11809  309 HAIGKasngrgiyEG--PGISIKLSALHPRYSRaqyDRVMEELyprlKSLTLLARQYDIGINIDAEEADRLEISLDLLEK 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922  149 LKSE-----YDNIGTVIQAYLYRTEK------DMEELNAYSPNLRLVKGAYKEPE------------DVaFPDKKDVDDN 205
Cdd:PRK11809  387 LCFEpelagWNGIGFVIQAYQKRCPFvidyliDLARRSRRRLMIRLVKGAYWDSEikraqvdglegyPV-YTRKVYTDVS 465

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922  206 Y----KKiikmhLL---NGNYTAIASHDEAIIEYTKKLAEEHNIPrDQFEFQMLYGIrNERQLELV-------KEGYKMR 271
Cdd:PRK11809  466 YlacaRK-----LLavpNLIYPQFATHNAHTLAAIYHLAGQNYYP-GQYEFQCLHGM-GEPLYEQVvgkvadgKLNRPCR 538

                         330       340
                  ....*....|....*....|....*....
gi 446358922  272 VYVPYGN--DWYGYFMRRLAERPANVAFV 298
Cdd:PRK11809  539 IYAPVGTheTLLAYLVRRLLENGANTSFV 567
PLN02681 PLN02681
proline dehydrogenase
 34-291 8.19e-06

proline dehydrogenase


Pssm-ID: 215366 [Multi-domain]  Cd Length: 455  Bit Score: 47.00  E-value: 8.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922  34 FVAGETIELATAAIKQLNKQGLCVTIDYLGEFVDNEAEANEMASESIEAIRAIGR-EGLNSQLSLKMTSMG--------- 103
Cdd:PLN02681  88 FCAGEDAEEAARTVRRLWELGLGGILDYAAEDAGDNAACDRNLEKFLAAIRAAATlPPSSSSAAVKITALCppsllervs 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922 104 ---------------------------------------LDISDEIVMNNM----RRILEAGKENGVFITIDME------ 134
Cdd:PLN02681 168 dllrwqdrdpngklpwkqwsfplfadssplyhatsepepLTAEEERLLELAherlQKLCERAAQLGVPLLIDAEytslqp 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922 135 --DYTRCGKTIEIFKqlKSEYDNIGTVIQAYLY----RTEKDME--ELNAYSPNLRLVKGAY--KEPEDVAF-------- 196
Cdd:PLN02681 248 aiDYITYDLAREFNK--GKDRPIVYGTYQAYLKdareRLRLDLErsEREGVPLGAKLVRGAYlsLERRLAASlgvpspvh 325

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446358922 197 PDKKDVDDNYKK---IIKMHLLNGNYTAI-ASHDEAIIEYTKKLAEEHNIPR--DQFEFQMLYGIRNERQLELVKEGYKM 270
Cdd:PLN02681 326 DTIQDTHACYNRcaeFLLEKASNGDGEVMlATHNVESGELAAAKMNELGLHKgdPRVQFAQLLGMSDNLSFGLGNAGFRV 405

                        330       340
                 ....*....|....*....|...
gi 446358922 271 RVYVPYG--NDWYGYFMRRLAER 291
Cdd:PLN02681 406 SKYLPYGpvEEVIPYLLRRAEEN 428
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH