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Conserved domains on  [gi|446362330|ref|WP_000440185|]
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MULTISPECIES: PdxA family protein [Enterobacteriaceae]

Protein Classification

PdxA family protein( domain architecture ID 10005086)

PdxA family protein similar to 4-hydroxythreonine-4-phosphate dehydrogenase that catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 3-amino-2-oxopropyl phosphate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PdxA COG1995
4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; ...
3-330 8.17e-132

4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; 4-hydroxy-L-threonine phosphate dehydrogenase PdxA is part of the Pathway/BioSystem: Pyridoxal phosphate biosynthesis


:

Pssm-ID: 441598  Cd Length: 330  Bit Score: 378.64  E-value: 8.17e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330   3 RKPVLGIFLGEAAGIGPELVAKVVADGTVYKYCRPVLIGDARVLALGQKIAGVHFQWNVISDPTEADWTTGNVPLLDLKN 82
Cdd:COG1995    1 TKPRIAITMGDPAGIGPEIILKALADPRILELCRPVVIGDPKVLERAAKQLGLDLPLREIDSPAEAAANPGTLNVLDVGN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  83 fNPEKLTMGTIDTDSGYATGESLVTCMSLLKSGKIDGFVFAPLNKEAFKKGGWDIEDEHYLFAEQLGyLDKPrGLLNVLG 162
Cdd:COG1995   81 -DAAPVEPGKPSAAAGRAALESLERAVELALAGEIDALVTAPINKEAINAAGFPFPGHTEFLAELTG-TKDV-VMMLAGE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 163 DLWVFRVTGHIPFKDIASHITPENVSRSIQLCYDTLRM-AAVENPRIAVAALNPHAGDGGTCGKEEIDVLIPVIEGFREK 241
Cdd:COG1995  158 GLRVALVTTHIPLRDVPDAITPERILETIRLLHRALRRdFGIAKPRIAVAGLNPHAGEGGLFGREEIDIIAPAIEAARAE 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 242 GMDMYGPVPGDTVFIHAFNHEYDAVVTLFHDQGQIATKLHSFDVGITVAAGLPFAITTPEHGTAFDIAGKGIAKTLATER 321
Cdd:COG1995  238 GIDVSGPLPADTLFHRAARGEYDAVLAMYHDQGLIPLKLLGFDRGVNVTLGLPFIRTSVDHGTAFDIAGKGIADPGSLIA 317

                 ....*....
gi 446362330 322 AIAVAARMA 330
Cdd:COG1995  318 AIRLAARLA 326
 
Name Accession Description Interval E-value
PdxA COG1995
4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; ...
3-330 8.17e-132

4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; 4-hydroxy-L-threonine phosphate dehydrogenase PdxA is part of the Pathway/BioSystem: Pyridoxal phosphate biosynthesis


Pssm-ID: 441598  Cd Length: 330  Bit Score: 378.64  E-value: 8.17e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330   3 RKPVLGIFLGEAAGIGPELVAKVVADGTVYKYCRPVLIGDARVLALGQKIAGVHFQWNVISDPTEADWTTGNVPLLDLKN 82
Cdd:COG1995    1 TKPRIAITMGDPAGIGPEIILKALADPRILELCRPVVIGDPKVLERAAKQLGLDLPLREIDSPAEAAANPGTLNVLDVGN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  83 fNPEKLTMGTIDTDSGYATGESLVTCMSLLKSGKIDGFVFAPLNKEAFKKGGWDIEDEHYLFAEQLGyLDKPrGLLNVLG 162
Cdd:COG1995   81 -DAAPVEPGKPSAAAGRAALESLERAVELALAGEIDALVTAPINKEAINAAGFPFPGHTEFLAELTG-TKDV-VMMLAGE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 163 DLWVFRVTGHIPFKDIASHITPENVSRSIQLCYDTLRM-AAVENPRIAVAALNPHAGDGGTCGKEEIDVLIPVIEGFREK 241
Cdd:COG1995  158 GLRVALVTTHIPLRDVPDAITPERILETIRLLHRALRRdFGIAKPRIAVAGLNPHAGEGGLFGREEIDIIAPAIEAARAE 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 242 GMDMYGPVPGDTVFIHAFNHEYDAVVTLFHDQGQIATKLHSFDVGITVAAGLPFAITTPEHGTAFDIAGKGIAKTLATER 321
Cdd:COG1995  238 GIDVSGPLPADTLFHRAARGEYDAVLAMYHDQGLIPLKLLGFDRGVNVTLGLPFIRTSVDHGTAFDIAGKGIADPGSLIA 317

                 ....*....
gi 446362330 322 AIAVAARMA 330
Cdd:COG1995  318 AIRLAARLA 326
pdxA PRK00232
4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed
1-331 1.31e-127

4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed


Pssm-ID: 234696  Cd Length: 332  Bit Score: 368.34  E-value: 1.31e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330   1 MERKPVLGIFLGEAAGIGPELVAKVVADGTVYKYCRPVLIGDARVLALGQKIAGVHFQWNVISDPTEADWTTGNVPLLDL 80
Cdd:PRK00232   1 MMMKPRIAITPGDPAGIGPELVAKLLAQPDVRWPAELVVIADRALLERRAAILGLPLDLRPYSPDAPAQPQEAGTLTVLP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  81 KNFNPEkLTMGTIDTDSGYATGESLVTCMSLLKSGKIDGFVFAPLNKEAFKKGGWDIEDEHYLFAEQLGYlDKPRGLLNV 160
Cdd:PRK00232  81 VPLAPA-VVAGQLDAANGRYVLETLARALDGCLAGEFDAICTAPVNKGAINDAGIPFSGHTEFFAELSGT-TGVVMMLAT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 161 lGDLWVFRVTGHIPFKDIASHITPENVSRSIQLCYDTLRMAAVENPRIAVAALNPHAGDGGTCGKEEIDVLIPVIEGFRE 240
Cdd:PRK00232 159 -EGLRVALVTTHLPLRDVADAITPERLEEVIRILHADLRRKGIAEPRIAVCGLNPHAGEGGHFGREEIDIIIPALEELRA 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 241 KGMDMYGPVPGDTVFIHAFNHEYDAVVTLFHDQGQIATKLHSFDVGITVAAGLPFAITTPEHGTAFDIAGKGIAKTLATE 320
Cdd:PRK00232 238 EGINLVGPLPADTLFQPAYLGDADAVLAMYHDQGLPVLKYLGFGRGVNITLGLPFIRTSVDHGTALDLAGKGIADVGSFI 317
                        330
                 ....*....|.
gi 446362330 321 RAIAVAARMAS 331
Cdd:PRK00232 318 TALNLAIRMAA 328
PdxA pfam04166
Pyridoxal phosphate biosynthetic protein PdxA; In Escherichia coli the coenzyme pyridoxal 5 ...
33-326 2.23e-94

Pyridoxal phosphate biosynthetic protein PdxA; In Escherichia coli the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that is thought to involve the condensation of 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose, catalyzed by the enzymes PdxA and PdxJ, to form either pyridoxine (vitamin B6) or pyridoxine 5'-phosphate.


Pssm-ID: 461203  Cd Length: 251  Bit Score: 280.81  E-value: 2.23e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330   33 KYCRPVLIGDARVLALGQkiagvhfqwnvisdpteadwttgnvplldlknfnpekltmgtIDTDSGYATGESLVTCMSLL 112
Cdd:pfam04166   1 ELCTPVVVGDPKVLRPGK------------------------------------------PSAESGAAALAYLERAVELA 38
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  113 KSGKIDGFVFAPLNKEAFKKGGWDIEDEHYLFAEQLGyLDKPRGLLNVlGDLWVFRVTGHIPFKDIASHITPENVSRSIQ 192
Cdd:pfam04166  39 LAGEFDALVTAPINKEAINAAGFPFPGHTEYLAELTG-TKDVVMMLAG-EGLRVALVTTHIPLKDVPAAITPERILEKIR 116
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  193 LCYDTLRMA-AVENPRIAVAALNPHAGDGGTCGKEEIDVLIPVIEGFREKGMDMYGPVPGDTVFIHAFNHEYDAVVTLFH 271
Cdd:pfam04166 117 LLHKALKRDfGIANPRIAVAGLNPHAGEGGLFGREEIEIIIPAIEKARAEGIDVFGPLPADTLFGKAARGKFDAVLAMYH 196
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 446362330  272 DQGQIATKLHSFDVGITVAAGLPFAITTPEHGTAFDIAGKGIAKTLATERAIAVA 326
Cdd:pfam04166 197 DQGLIPLKTLGFDRGVNVTLGLPIIRTSVDHGTAFDIAGKGIADPGSLREAIRLA 251
pdxA TIGR00557
4-hydroxythreonine-4-phosphate dehydrogenase; This model represents PdxA, an NAD+-dependent ...
7-330 7.74e-82

4-hydroxythreonine-4-phosphate dehydrogenase; This model represents PdxA, an NAD+-dependent 4-hydroxythreonine 4-phosphate dehydrogenase (EC 1.1.1.262) active in pyridoxal phosphate biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridoxine]


Pssm-ID: 273137  Cd Length: 320  Bit Score: 251.25  E-value: 7.74e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330    7 LGIFLGEAAGIGPELVAKVVADgtVYKYCRPVLIGDARVLALGQKIAGVHFQWNVISDPTEADWTTGNVPLLDLKNfnPE 86
Cdd:TIGR00557   2 IAITLGDPAGIGPEIILKALAQ--LAELCPPVVIGDPALLEARAKLLGLLPLVAIDAPEDAAAAFPGALPVLPVPL--AA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330   87 KLTMGTIDTDSGYATGESLVTCMSLLKSGKIDGFVFAPLNKEAFKKGGwdiedehYLFAEQLGYL------DKPRGLLnV 160
Cdd:TIGR00557  78 PVTPGKPDPANGAAVFETLERAVELCLAGEADALVTAPIHKGAINAAG-------FPFPGHTEFLaeltgvPDVVMML-A 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  161 LGDLWVFRVTGHIPFKDIASHITPENVSRSIQLCYDTLRMA-AVENPRIAVAALNPHAGDGGTCGKEEIDVLIPVIEGFR 239
Cdd:TIGR00557 150 GPGLRVALATTHIPLKDVPAALTPELLLEKLRILHADLRRDfGIARPRIAVAGLNPHAGEGGHLGREEIDIIIPALEALR 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  240 EKGMDMYGPVPGDTVFIHAFNHEYDAVVTLFHDQGQIATKLHSFDVGITVAAGLPFAITTPEHGTAFDIAGKGIAKTLAT 319
Cdd:TIGR00557 230 AEGIDLIGPLPADTLFHPAALAKYDAVLAMYHDQGLIPLKYLGFDEGVNVTLGLPFIRTSPDHGTAFDIAGKGKADPGSL 309
                         330
                  ....*....|.
gi 446362330  320 ERAIAVAARMA 330
Cdd:TIGR00557 310 IAAIKLAIELA 320
 
Name Accession Description Interval E-value
PdxA COG1995
4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; ...
3-330 8.17e-132

4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; 4-hydroxy-L-threonine phosphate dehydrogenase PdxA is part of the Pathway/BioSystem: Pyridoxal phosphate biosynthesis


Pssm-ID: 441598  Cd Length: 330  Bit Score: 378.64  E-value: 8.17e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330   3 RKPVLGIFLGEAAGIGPELVAKVVADGTVYKYCRPVLIGDARVLALGQKIAGVHFQWNVISDPTEADWTTGNVPLLDLKN 82
Cdd:COG1995    1 TKPRIAITMGDPAGIGPEIILKALADPRILELCRPVVIGDPKVLERAAKQLGLDLPLREIDSPAEAAANPGTLNVLDVGN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  83 fNPEKLTMGTIDTDSGYATGESLVTCMSLLKSGKIDGFVFAPLNKEAFKKGGWDIEDEHYLFAEQLGyLDKPrGLLNVLG 162
Cdd:COG1995   81 -DAAPVEPGKPSAAAGRAALESLERAVELALAGEIDALVTAPINKEAINAAGFPFPGHTEFLAELTG-TKDV-VMMLAGE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 163 DLWVFRVTGHIPFKDIASHITPENVSRSIQLCYDTLRM-AAVENPRIAVAALNPHAGDGGTCGKEEIDVLIPVIEGFREK 241
Cdd:COG1995  158 GLRVALVTTHIPLRDVPDAITPERILETIRLLHRALRRdFGIAKPRIAVAGLNPHAGEGGLFGREEIDIIAPAIEAARAE 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 242 GMDMYGPVPGDTVFIHAFNHEYDAVVTLFHDQGQIATKLHSFDVGITVAAGLPFAITTPEHGTAFDIAGKGIAKTLATER 321
Cdd:COG1995  238 GIDVSGPLPADTLFHRAARGEYDAVLAMYHDQGLIPLKLLGFDRGVNVTLGLPFIRTSVDHGTAFDIAGKGIADPGSLIA 317

                 ....*....
gi 446362330 322 AIAVAARMA 330
Cdd:COG1995  318 AIRLAARLA 326
pdxA PRK00232
4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed
1-331 1.31e-127

4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed


Pssm-ID: 234696  Cd Length: 332  Bit Score: 368.34  E-value: 1.31e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330   1 MERKPVLGIFLGEAAGIGPELVAKVVADGTVYKYCRPVLIGDARVLALGQKIAGVHFQWNVISDPTEADWTTGNVPLLDL 80
Cdd:PRK00232   1 MMMKPRIAITPGDPAGIGPELVAKLLAQPDVRWPAELVVIADRALLERRAAILGLPLDLRPYSPDAPAQPQEAGTLTVLP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  81 KNFNPEkLTMGTIDTDSGYATGESLVTCMSLLKSGKIDGFVFAPLNKEAFKKGGWDIEDEHYLFAEQLGYlDKPRGLLNV 160
Cdd:PRK00232  81 VPLAPA-VVAGQLDAANGRYVLETLARALDGCLAGEFDAICTAPVNKGAINDAGIPFSGHTEFFAELSGT-TGVVMMLAT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 161 lGDLWVFRVTGHIPFKDIASHITPENVSRSIQLCYDTLRMAAVENPRIAVAALNPHAGDGGTCGKEEIDVLIPVIEGFRE 240
Cdd:PRK00232 159 -EGLRVALVTTHLPLRDVADAITPERLEEVIRILHADLRRKGIAEPRIAVCGLNPHAGEGGHFGREEIDIIIPALEELRA 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 241 KGMDMYGPVPGDTVFIHAFNHEYDAVVTLFHDQGQIATKLHSFDVGITVAAGLPFAITTPEHGTAFDIAGKGIAKTLATE 320
Cdd:PRK00232 238 EGINLVGPLPADTLFQPAYLGDADAVLAMYHDQGLPVLKYLGFGRGVNITLGLPFIRTSVDHGTALDLAGKGIADVGSFI 317
                        330
                 ....*....|.
gi 446362330 321 RAIAVAARMAS 331
Cdd:PRK00232 318 TALNLAIRMAA 328
pdxA PRK03743
4-hydroxythreonine-4-phosphate dehydrogenase PdxA;
2-335 1.61e-95

4-hydroxythreonine-4-phosphate dehydrogenase PdxA;


Pssm-ID: 179641  Cd Length: 332  Bit Score: 286.51  E-value: 1.61e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330   2 ERKPVLGIFLGEAAGIGPELVAKVVADGTVYKYCRPVLIGDARVLALGQKIAGVHFQWNVISDPTEADWTTGNVPLLDLK 81
Cdd:PRK03743   1 MKKPIIAIPIGDPAGIGPEIVVKTLADKEVYDECKPFLIGDAPVIERAMKICGVDLNINKIKKPAEGKFEWGTIDLIDLG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  82 NFNPEKLTMGTIDTDSGYATGESLVTCMSLLKSGKIDGFVFAPLNKEAFKKGGWDIEDEHYLFAEQLGYLDkPRGLLNVl 161
Cdd:PRK03743  81 NYDCDSIKWGKVQALAGKAAFEYIKKSVELAMEGKVDAVATTPINKEALKAAGVKYIGHTEILADLTGTED-PLTMFEV- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 162 GDLWVFRVTGHIPFKDIASHITPENVSRSIQLCYDTLRMAAVENPRIAVAALNPHAGDGGTCGKEEIDVLIPVIEGFREK 241
Cdd:PRK03743 159 RNLRVFFLTRHVSLKKACDYVTKERVLDYIQRCTKALEKLGIKNPKIAVAGLNPHSGEHGLFGDEEVDEIIPAVEAAQEM 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 242 GMDMYGPVPGDTVFIHAFNHEYDAVVTLFHDQGQIATKLHSFDVGITVAAGLPFAITTPEHGTAFDIAGKGIAKTLATER 321
Cdd:PRK03743 239 GINVEGPVPADSVFHLALQGRYDAVLSLYHDQGHIATKTLDFERTIAITNGLPFLRTSVDHGTAFDIAGTGKASSVSMEE 318
                        330
                 ....*....|....
gi 446362330 322 AIAVAARMASTVHK 335
Cdd:PRK03743 319 AILLAAKYAPMFKK 332
PdxA pfam04166
Pyridoxal phosphate biosynthetic protein PdxA; In Escherichia coli the coenzyme pyridoxal 5 ...
33-326 2.23e-94

Pyridoxal phosphate biosynthetic protein PdxA; In Escherichia coli the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that is thought to involve the condensation of 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose, catalyzed by the enzymes PdxA and PdxJ, to form either pyridoxine (vitamin B6) or pyridoxine 5'-phosphate.


Pssm-ID: 461203  Cd Length: 251  Bit Score: 280.81  E-value: 2.23e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330   33 KYCRPVLIGDARVLALGQkiagvhfqwnvisdpteadwttgnvplldlknfnpekltmgtIDTDSGYATGESLVTCMSLL 112
Cdd:pfam04166   1 ELCTPVVVGDPKVLRPGK------------------------------------------PSAESGAAALAYLERAVELA 38
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  113 KSGKIDGFVFAPLNKEAFKKGGWDIEDEHYLFAEQLGyLDKPRGLLNVlGDLWVFRVTGHIPFKDIASHITPENVSRSIQ 192
Cdd:pfam04166  39 LAGEFDALVTAPINKEAINAAGFPFPGHTEYLAELTG-TKDVVMMLAG-EGLRVALVTTHIPLKDVPAAITPERILEKIR 116
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  193 LCYDTLRMA-AVENPRIAVAALNPHAGDGGTCGKEEIDVLIPVIEGFREKGMDMYGPVPGDTVFIHAFNHEYDAVVTLFH 271
Cdd:pfam04166 117 LLHKALKRDfGIANPRIAVAGLNPHAGEGGLFGREEIEIIIPAIEKARAEGIDVFGPLPADTLFGKAARGKFDAVLAMYH 196
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 446362330  272 DQGQIATKLHSFDVGITVAAGLPFAITTPEHGTAFDIAGKGIAKTLATERAIAVA 326
Cdd:pfam04166 197 DQGLIPLKTLGFDRGVNVTLGLPIIRTSVDHGTAFDIAGKGIADPGSLREAIRLA 251
pdxA TIGR00557
4-hydroxythreonine-4-phosphate dehydrogenase; This model represents PdxA, an NAD+-dependent ...
7-330 7.74e-82

4-hydroxythreonine-4-phosphate dehydrogenase; This model represents PdxA, an NAD+-dependent 4-hydroxythreonine 4-phosphate dehydrogenase (EC 1.1.1.262) active in pyridoxal phosphate biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridoxine]


Pssm-ID: 273137  Cd Length: 320  Bit Score: 251.25  E-value: 7.74e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330    7 LGIFLGEAAGIGPELVAKVVADgtVYKYCRPVLIGDARVLALGQKIAGVHFQWNVISDPTEADWTTGNVPLLDLKNfnPE 86
Cdd:TIGR00557   2 IAITLGDPAGIGPEIILKALAQ--LAELCPPVVIGDPALLEARAKLLGLLPLVAIDAPEDAAAAFPGALPVLPVPL--AA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330   87 KLTMGTIDTDSGYATGESLVTCMSLLKSGKIDGFVFAPLNKEAFKKGGwdiedehYLFAEQLGYL------DKPRGLLnV 160
Cdd:TIGR00557  78 PVTPGKPDPANGAAVFETLERAVELCLAGEADALVTAPIHKGAINAAG-------FPFPGHTEFLaeltgvPDVVMML-A 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  161 LGDLWVFRVTGHIPFKDIASHITPENVSRSIQLCYDTLRMA-AVENPRIAVAALNPHAGDGGTCGKEEIDVLIPVIEGFR 239
Cdd:TIGR00557 150 GPGLRVALATTHIPLKDVPAALTPELLLEKLRILHADLRRDfGIARPRIAVAGLNPHAGEGGHLGREEIDIIIPALEALR 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  240 EKGMDMYGPVPGDTVFIHAFNHEYDAVVTLFHDQGQIATKLHSFDVGITVAAGLPFAITTPEHGTAFDIAGKGIAKTLAT 319
Cdd:TIGR00557 230 AEGIDLIGPLPADTLFHPAALAKYDAVLAMYHDQGLIPLKYLGFDEGVNVTLGLPFIRTSPDHGTAFDIAGKGKADPGSL 309
                         330
                  ....*....|.
gi 446362330  320 ERAIAVAARMA 330
Cdd:TIGR00557 310 IAAIKLAIELA 320
pdxA PRK05312
4-hydroxythreonine-4-phosphate dehydrogenase PdxA;
1-332 3.07e-66

4-hydroxythreonine-4-phosphate dehydrogenase PdxA;


Pssm-ID: 235402  Cd Length: 336  Bit Score: 211.67  E-value: 3.07e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330   1 MERKPvLGIFLGEAAGIGPELVAKV----VADGTVykycrP-VLIGDARVLALGQKIAGVHFQWNVISDPTEA-DWTTGN 74
Cdd:PRK05312   1 MMMRP-LALSLGDPAGIGPEIALKAwlrrRELGLP-----PfFLIGDPAVLAARARLLGLDVPVAEVTDPEEAaAVFADA 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  75 VPLLDLKNfnPEKLTMGTIDTDSGYATGESLVTCMSLLKSGKIDGFVFAPLNKEAFKKGGwdiedehylFA-----EQLG 149
Cdd:PRK05312  75 LPVLPLPF--PAPVVPGQPDPANAAGVIAAIERAVGLVLSGEAAAVVTAPIAKKVLYDAG---------FAfpghtEFLA 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 150 YL-----DKPRGLLNVL--GDLWVFRVTGHIPFKDIASHITPEnvsrsiqLCYDTLRMAA--------VENPRIAVAALN 214
Cdd:PRK05312 144 ELagvatGKPVQPVMMLagPQLRVVPVTIHIPLRDVPAALTPE-------LIVATARITAadlrrrfgIASPRLAVAGLN 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 215 PHAGDGGTCGKEEIDVLIPVIEGFREKGMDMYGPVPGDTVFIHAFNHEYDAVVTLFHDQGQIATKLHSFDVGITVAAGLP 294
Cdd:PRK05312 217 PHAGEGGALGREDIDIIAPAIEQLRAEGIDARGPLPADTMFHAAARATYDAAICMYHDQALIPIKTLDFDGGVNVTLGLP 296
                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 446362330 295 FAITTPEHGTAFDIAGKGIAKTLATERAIAVAARMAST 332
Cdd:PRK05312 297 FIRTSPDHGTAFDIAGKGIARPDSLIAALRLAAQMAAN 334
pdxA PRK03371
D-threonate 4-phosphate dehydrogenase;
6-330 5.17e-60

D-threonate 4-phosphate dehydrogenase;


Pssm-ID: 179572  Cd Length: 326  Bit Score: 195.43  E-value: 5.17e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330   6 VLGIFLGEAAGIGPELVAKVVADGTVYKyCRPVLIGDA----RVLALGqkIAGvHFQWNVISDPTEADWTTGNVPLLDLK 81
Cdd:PRK03371   4 IIAVTMGDPAGIGPEIIIKSLSEGGLNG-APLVVVGCLatlrRILAKG--ITP-QVELRAIERVAEARFAPGIINVIDEP 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  82 NFNPEKLTMGTIDTDSGYATGESLVTCMSLLKSGKIDGFVFAPLNKEAFKKGGwdiedEHYL-FAEQLGYLDKPRGLLNV 160
Cdd:PRK03371  80 LAQPEALEPGVVQAQAGDLAYRCVKRATELALRGEVQAIATAPLNKEALHLAG-----HNYPgHTELLATLTHSRDYAMV 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 161 L--GDLWVFRVTGHIPFKDIASHITPENVSRSIQLCYDTLRMAAVENPRIAVAALNPHAGDGGTCGKEEIDVLIPVIEGF 238
Cdd:PRK03371 155 LytDKLKVIHVSTHIALRKFLDTLNTARVETVIGIADTFLKRVGYVKPRIAVAGVNPHAGENGLFGDEEIRIVTPAIEAM 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 239 REKGMDMYGPVPGDTVFIHAFNHEYDAVVTLFHDQGQIATKLHSFDVGITVAAGLPFAITTPEHGTAFDIAGKGIAKTLA 318
Cdd:PRK03371 235 RAKGMDVYGPCPPDTVFLQAYEGQYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHGTAFDIAWTGKAKSES 314
                        330
                 ....*....|..
gi 446362330 319 TERAIAVAARMA 330
Cdd:PRK03371 315 MAVSIKLAMQLA 326
pdxA PRK02746
4-hydroxythreonine-4-phosphate dehydrogenase PdxA;
4-330 4.52e-57

4-hydroxythreonine-4-phosphate dehydrogenase PdxA;


Pssm-ID: 235066  Cd Length: 345  Bit Score: 188.19  E-value: 4.52e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330   4 KPVLGIFLGEAAGIGPELVAKVVADGTVYKYCRPVLIGDARVLALGQKiagvHFQwnvisdpteadwTTGNVPLLDLKNF 83
Cdd:PRK02746   9 RPRLAITLGDPAGIGPEVILKALASPELPENCQPTLVGCRSLLEQTYQ----RLK------------SQGIEPLADPANL 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  84 N------PEKLTMGTIDTDSGYATGESLVTCMSLLKSGKIDGFVFAPLNKEAFKKGGWDIEDEHYLFAEQLGyLDKPrGL 157
Cdd:PRK02746  73 DildiplDSTIIPGKGNAASGAASFAYLTTAIEITLAGEFDAIVTAPIAKSAWHAAGHHYPGQTEVLAELAG-VERF-GM 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 158 LNVL-----GdlWVFRV---TGHIPFKDIASHITPENVSRSIQLCYDTLR-MAAVENPRIAVAALNPHAGDGGTCGKEEI 228
Cdd:PRK02746 151 LFTArsphtG--WRLRTllaTTHIPLCQVPKTLTPELITSKLDLLIDFLQrDFGIEKPRIAIAGLNPHAGEQGQLGTEEK 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 229 DVLIPVIEGFREK--GMDMYGPVPGDTVFIHA--------FNHEYDAVVTLFHDQGQIATKLHSFDVGITVAAGLPFAIT 298
Cdd:PRK02746 229 DWLIPWLESWRQKnpDIQLLGPIPPDTCWVSPaqawygkgVAEAPDGYLALYHDQGLIPVKLMAFDRAVNTTIGLPFIRT 308
                        330       340       350
                 ....*....|....*....|....*....|..
gi 446362330 299 TPEHGTAFDIAGKGIAKTLATERAIAVAARMA 330
Cdd:PRK02746 309 SPDHGTAFDIAGKGIARPQSMKAAIKLAWELS 340
pdxA PRK01909
4-hydroxythreonine-4-phosphate dehydrogenase PdxA;
1-330 1.87e-45

4-hydroxythreonine-4-phosphate dehydrogenase PdxA;


Pssm-ID: 234991  Cd Length: 329  Bit Score: 157.59  E-value: 1.87e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330   1 MERKPVLGIFLGEAAGIGPELVAKVVAD-GTVYKYCRPVLIGDARVLAlgQKIAGVHFQWNVISdpTEADWTTGNVPLld 79
Cdd:PRK01909   2 TPQPLQIAITTGEPAGVGPELTVRALADaAARWPDARFTVLGDAALLA--ARAAAVGADWARLA--AGGHVTVAHRPL-- 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  80 lknfnPEKLTMGTIDTDSGYATGESLVTCMSLLKSGKIDGFVFAPLNKEAFKKGGWDIEDEHYLFAEQLGyldKPRGLLN 159
Cdd:PRK01909  76 -----AAPAEAGKLDAANGRYVLDLLDAAIDGALAGRYDAIVTAPLQKSTINDAGVPFTGHTEYLAERTH---TPRVVMM 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 160 VLGD----LWVFRVTGHIPFKDIASHITPENVSRSIQLCYDTLRMA-AVENPRIAVAALNPHAGDGGTCGKEEIDVLIPV 234
Cdd:PRK01909 148 LAGTgprpLRVALATTHLPLKDVSAALTIDGLVETLAIIDRDLRRDfGLAAPRILVTGLNPHAGENGYLGREEIDVIEPA 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 235 IEGFREKGMDMYGPVPGDTVFIHAFNHEYDAVVTLFHDQGQIATKLHSFDVGITVAAGLPFAITTPEHGTAFDIAGKGIA 314
Cdd:PRK01909 228 LARARAAGIDARGPYPADTLFQPRYLEDADCVLAMFHDQGLPVLKYATFGEGINVTLGLPIIRTSVDHGTALDLAGTGRA 307
                        330
                 ....*....|....*.
gi 446362330 315 KTLATERAIAVAARMA 330
Cdd:PRK01909 308 DPGSMIAAIDTAVTMA 323
pdxA PRK03946
4-hydroxythreonine-4-phosphate dehydrogenase; Provisional
4-332 1.74e-38

4-hydroxythreonine-4-phosphate dehydrogenase; Provisional


Pssm-ID: 179681  Cd Length: 307  Bit Score: 138.59  E-value: 1.74e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330   4 KPVLGIFLGEAAGIGPELVAKvvADGTVYKYCRPVLIGDARVLALGQKIAGVHfqwnvISDPTEADWTTGnvplldlKNF 83
Cdd:PRK03946   1 KKKIAISIGDINGIGLEIALK--SHDEVSKICEPLYCINEELLEQAAKLLNLK-----TPNDFEIDFPVG-------LLF 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330  84 npeKLTMGTIDTDSGYATGESLVTCMSLLKSGKIDGFVFAPLNKEAFKKGGWdiedeHYLfaeqlGYLDKPRGLLN---- 159
Cdd:PRK03946  67 ---EIKPGKVSAKSGAYSFESFKKAVELADSKEVDAIVTLPINKKAWQKAGI-----PYK-----GHTDALRDRFKkeai 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 160 -VLG--DLWVFRVTGHIPFKDIASHITPENVSRSIQLCYdtlrmAAVENPRIAVAALNPHAGDGGTCGKEEIDVLIPVIE 236
Cdd:PRK03946 134 mMLGceELFVALFTDHIPLKKVSQLIKVKKLVKFLLDFY-----KSTKFKKIGVLGLNPHAGDNGVIGGEEEEIKKAIKK 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362330 237 GFREKGMDMY-GPVPGDTVFIHAFNHEYDAVVTLFHDQGQIATKLHSFDVGITVAAGLPFAITTPEHGTAFDIAGKGI-A 314
Cdd:PRK03946 209 ANQFLGFEIFfGPLVPDSAFTPNKRKKFNYYVAMYHDQGLAPLKALYFDESINVSLNLPILRTSVDHGTAFDIAYKNAkA 288
                        330
                 ....*....|....*...
gi 446362330 315 KTLATERAIAVAARMAST 332
Cdd:PRK03946 289 NTKSYLNAIKYAINLLSK 306
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
295-329 6.28e-03

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 38.04  E-value: 6.28e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 446362330  295 FAITTPEHGTAFDIAGKGIAKTLATeraIAVAARM 329
Cdd:pfam00180 268 FGIFEPVHGSAPDIAGKGIANPIAT---ILSAAMM 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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