|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
12-371 |
1.20e-101 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 305.29 E-value: 1.20e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 12 MTFAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNL 91
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 92 ASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLS 171
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 172 FMAVLLSLMTKMPFTPQKE------KGKIQLFEKSVLSITIVVFFLSFAYGGITTFLPLFASSI-DVNPGTFFLVYAIAL 244
Cdd:cd17489 161 LLALLLVFLVKDPPPVAAEeaeagtRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERgISNAGLFFTVYAIAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 245 TIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANAS 324
Cdd:cd17489 241 LLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGT 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446362813 325 FFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVFFV 371
Cdd:cd17489 321 FFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-371 |
7.82e-56 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 187.40 E-value: 7.82e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 13 TFAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLA 92
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 93 STIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSF 172
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 173 MAVLLSLMTKMPFTPQKEKGKIQ-----------LFEKSVLSITIVVFFLSFAYGGITTFLPLFASS-IDVNP---GTFF 237
Cdd:cd17325 162 LALVLALLLLPEPRPPPNKRAVSaarlrsglrllLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAElGGLSPaqiGLLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 238 LVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSK 317
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 446362813 318 RGVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVFFV 371
Cdd:cd17325 322 RGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-335 |
1.30e-39 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 143.96 E-value: 1.30e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 12 MTFAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNL 91
Cdd:COG2814 15 LALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 92 ASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLS 171
Cdd:COG2814 95 APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 172 FMAVLLSLMTkMPFTPQKEKGKIQ------LFEKSVLSITIVVFFLSFAYGGITTFLPLFASSI----DVNPGTFFLVYA 241
Cdd:COG2814 175 LLALLLLLRL-LPESRPAARARLRgslrelLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlglsASAAGLLLALFG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 242 IALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVA 321
Cdd:COG2814 254 LGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRA 333
|
330
....*....|....
gi 446362813 322 NASFFTAFDLGIGL 335
Cdd:COG2814 334 SGLYNSAFFLGGPL 347
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
12-367 |
1.92e-31 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 122.27 E-value: 1.92e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 12 MTFAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNL 91
Cdd:cd17324 4 LALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 92 ASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLS 171
Cdd:cd17324 84 APSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 172 FMAVLLsLMTKMPFTPQKEKGKIQLF--------EKSVLSITIVVFFLSFAYGGITTFLPLFASSIDVNPGTF----FLV 239
Cdd:cd17324 164 LLAALL-LWRLLPSLPPKKPGSLGLLsslllllrNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAiiglLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 240 YAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIvDPSKRG 319
Cdd:cd17324 243 FGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-APEARG 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 446362813 320 VANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIF 367
Cdd:cd17324 322 LASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
14-370 |
7.22e-30 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 118.06 E-value: 7.22e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 14 FAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLAS 93
Cdd:cd17474 6 FATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 94 TIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGlAVVQNYSFHGLFLLATLLSFM 173
Cdd:cd17474 86 SFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLG-GLLAAISWRYPFFLLAALIPV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 174 AVLLSLM--------TKMPFTPQKEKGKIQLFEKSVLSITIVVFFLSFAYGGITTFLPLFAS-SIDVNP---GTFFLVYA 241
Cdd:cd17474 165 AFLAILFllpepkekAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLElLYGISPiiiGLLFAGWS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 242 IALTIVRPISGKLLDK-YGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGV 320
Cdd:cd17474 245 VLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGT 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 446362813 321 ANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVFF 370
Cdd:cd17474 325 ASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-374 |
1.92e-28 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 113.81 E-value: 1.92e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 12 MTFAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNL 91
Cdd:COG2271 15 LFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 92 ASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLS 171
Cdd:COG2271 95 ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 172 FMAVLLslmtkmpftpqkekgkiqlfekSVLSITIVVFFLSFAYGGITTFLPLFASSI----DVNPGTFFLVYAIALTIV 247
Cdd:COG2271 175 LLLALL----------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVrglsLAQAGLLLSLPFLAGIVG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 248 RPISGKLLDKYGEVFIILPALC--ITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASF 325
Cdd:COG2271 233 SLLGGWLSDRLGRRRKLVLAIGllLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLV 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 446362813 326 FTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVFFVKQR 374
Cdd:COG2271 313 NTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
12-337 |
1.30e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 108.66 E-value: 1.30e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 12 MTFAMLFLFTGFYLLVPTLPLFI-KEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYN 90
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 91 LASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLL 170
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 171 SFMAVLLSLMTKMPFTPQKEKGKIQ-----------LFEKSVLSITIVVFFLSFAYGGITTFLPLFASSIDVNP---GTF 236
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEarlslivawkaLLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSAllaGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 237 FLVYAIALTIVRPISGKLLDKYGE---VFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIV 313
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRrrrLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 446362813 314 DPSKRGVANASFFTAFDLGIGLGA 337
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
12-371 |
2.12e-24 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 103.11 E-value: 2.12e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 12 MTFAMLFLFTGFYLLVPTLPLFIKEIGGNESQV-----GLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTM 86
Cdd:cd17391 1 CWLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLvelwsGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 87 YSYNLASTIVLLAVLRVIHGVTWAVSTTAVgTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLL 166
Cdd:cd17391 81 GLMAFVTNVWQLLILRLLQGVFSGYVPNAT-ALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 167 ATLLSFMAVLLSLM-TKMPFTPQKEKGKIQ--------LFEKSVLSITIVVFFLSFAYGGITTFLPLFASSIDVN----- 232
Cdd:cd17391 160 TGGLLFLAFLLTLFfVKEDFKPVEKKKMVStkevwnsvPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDasnla 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 233 --PGTFFLVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAML 310
Cdd:cd17391 240 fiSGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446362813 311 TIVDPSKRGVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVFFV 371
Cdd:cd17391 320 KITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
12-364 |
4.16e-24 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 101.87 E-value: 4.16e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 12 MTFAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNL 91
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 92 ASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLS 171
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 172 FMAVLLSlmtkmpftpqkekgkiqlfeKSVLSITIVVFFLSFAYGGITTFLPLFASSID----VNPGTFFLVYAIALTIV 247
Cdd:cd17321 161 LVALLLA--------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLgyspLQAGLALLPLALAMLVA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 248 RPISGKLLDKYGEVFIILPALCITIIAIVVLTI---SNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANAS 324
Cdd:cd17321 221 APLAGRLADRFGPRLVLVAGLLLTAVGLLLLALlgaDSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGI 300
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 446362813 325 FFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTAL 364
Cdd:cd17321 301 LNTARQLGGALGVALLGALLTAGLSANLGDSGVAALLSAA 340
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
9-370 |
8.34e-24 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 101.15 E-value: 8.34e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 9 FIQMTFAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRR-----SFIIFGLIFFG 83
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrllilADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 84 LTMYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGL 163
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 164 FLLATLLSFMAVLLSLMTKMPFTPQKEKGKIQLFEKS------------VLSITIVVFFLSFAYGGITTFLPLFASSI-- 229
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLreglrylrrsplLRLLLLALALFALLGGALTVLLPLLAKEVlg 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 230 --DVNPGTFFLVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQA 307
Cdd:cd06173 241 ggAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446362813 308 AMLTIVDPSKRGVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVFF 370
Cdd:cd06173 321 LLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
7-182 |
3.18e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 99.57 E-value: 3.18e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 7 KSFIQMTFAMLFLFTGFYLLVPTLPLFIKEIGG-NESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLT 85
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 86 MYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFL 165
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
170
....*....|....*..
gi 446362813 166 LATLLSFMAVLLSLMTK 182
Cdd:cd17325 359 AAAALLLLAAVLFLLLR 375
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
14-371 |
8.07e-23 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 98.45 E-value: 8.07e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 14 FAMLFLFTGFYLLVPTLPLFI-KEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLA 92
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 93 STIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQnYSFHGLFLLATLLSF 172
Cdd:cd17329 86 HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 173 MAVLLSLMTKMPFTPQKEKGKIQLFEKSVLSI---------TIVVFFLSFAYGGITTFLPLFASSIDVNP----GTFFLV 239
Cdd:cd17329 165 LAALVLLFLLPETRPKRRAAEKTEILRGYKIVlrdrafllfLLASFLISLIYFQLESTLPVYVVEILGLGesllGLLLAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 240 YAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRG 319
Cdd:cd17329 245 NALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRG 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446362813 320 VANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVFFV 371
Cdd:cd17329 325 SYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
20-369 |
9.04e-23 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 98.03 E-value: 9.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 20 FTGFYLLVPTLPLFIKEI---GGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIV 96
Cdd:cd17330 9 ALGFGIVFPVLPFYVREFnklGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 97 LLAVLRVIHGVTwAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFMAVL 176
Cdd:cd17330 89 LLFLARFLDGLT-GGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 177 LSLmtkmpftpqkekgkiqLFEKSVLSITIVVFFLSFAYGGITTFLPLFASSI----DVNPGTFFLVYAIALTIVR-PIS 251
Cdd:cd17330 168 LVL----------------FFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRfgfsPSQIGLLLALVGIAGILAQlLLI 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 252 GKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFFTAFDL 331
Cdd:cd17330 232 PRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSL 311
|
330 340 350
....*....|....*....|....*....|....*...
gi 446362813 332 GIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVF 369
Cdd:cd17330 312 ARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
6-373 |
2.75e-22 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 97.05 E-value: 2.75e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 6 TKSFIQMTFAMLFLFTGFYLLVPTLPLFI-KEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGL 84
Cdd:PRK12382 14 NFSLFRIAFAVFLTYMTVGLPLPVIPLFVhHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSALQGMLACGL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 85 TMYSYNLASTIVLLAVL--------RVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQ 156
Cdd:PRK12382 94 AGLAYLLAAILPVSAPFkfallvvgRLILGFGESQLLTGALTWGLGLVGPKHSGKVMSWNGMAMYGALAAGAPLGLLLHS 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 157 NYSFHGLFLLATLLSFMAvlLSLMTKMPFTP--QKEKGKIQLFEKSVLSITIVVFFLSFAYGGITTFLPLFASSIDVNPG 234
Cdd:PRK12382 174 HFGFAALALTTMVLPLLA--WAFNGTVRKVPahAGERPSLWSVVGLIWKPGLGLALQGVGFAVIGTFVSLYFASKGWAMA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 235 TF-FLVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIV 313
Cdd:PRK12382 252 GFtLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAALTGAGCSLIFPALGVEVVKRV 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 314 DPSKRGVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVFFVKQ 373
Cdd:PRK12382 332 PSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVLGIIVTILSFRR 391
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
14-365 |
5.97e-22 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 95.70 E-value: 5.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 14 FAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYG-RRSFIIFGLIFFGLTMySYNLA 92
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGhIRAFAAGAAITAVSVL-LLALT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 93 STIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIgLAVVQNYSFHgLFLLATLLSF 172
Cdd:cd17477 82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGAL-PFLIAAVLLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 173 MAVLLSLMTKMPFTPQKEKGKIQLFEKSVLSITIVV--FFLSFAYGGITTFLPLFASSIDVNP---GTFFLVYAIALTIV 247
Cdd:cd17477 160 LALVPLLLTRRAAPEIEEAESISLRRLLRIAPLALLgaFVAGFLEGAFYSLLPLYGLRLGLSVaqaALLLAAFVLGGLLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 248 RPISGKLLDKYGEVFIIL-PALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFF 326
Cdd:cd17477 240 QWPLGWLADRFDRRRVLLgCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALL 319
|
330 340 350
....*....|....*....|....*....|....*....
gi 446362813 327 TAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALI 365
Cdd:cd17477 320 LLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
25-368 |
1.62e-21 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 94.55 E-value: 1.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 25 LLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVI 104
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 105 HGVTWAVSTTAvGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFMAVLLSLMTKMP 184
Cdd:cd17478 94 AGIGSAAFHPE-GARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 185 FTPQKEKGK--------IQLFEKSVLSITIVVFFLSFAYGGITTFLPLFASSIDVNP---GTFFLVYAIALTIVRPISGK 253
Cdd:cd17478 173 KKPEAKKAAakssarstLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLvfaGLLLSLFLFAGAIGTLIGGP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 254 LLDKYGEVFIILPALCITIIAIvVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVdPSKRGVANASFFT-AFDLG 332
Cdd:cd17478 253 LSDRFGRRRVIIASLLLAAPFL-LLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELL-PGNVGLASGLMMGlSFGLG 330
|
330 340 350
....*....|....*....|....*....|....*.
gi 446362813 333 iGLGAILLGVVSQMFGYRILFSGSAISALTALIIFV 368
Cdd:cd17478 331 -GIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
27-368 |
5.72e-21 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 92.99 E-value: 5.72e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 27 VPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRR-SFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIH 105
Cdd:cd17370 19 RSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRkPLVILGYGLSALAKPLLALAGSWQLVLLLRILE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 106 GVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQ--NYSFHGLFLLATLLSFMAVLLSLM--- 180
Cdd:cd17370 99 RLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYllGGNYRTIFLLAAIPALLALLILLFvvk 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 181 ---TKMPFTPQKEKGKIQLFEKSVLSITIVVFFLSFAYGGITtFLPLFASSIDVNPGTFFLVYAIAL---TIVRPISGKL 254
Cdd:cd17370 179 eypRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFA-FLILRAQELGLSAALIPLLYALFNlvyALAAYPAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 255 LDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFFTAFDLGIG 334
Cdd:cd17370 258 SDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWL 337
|
330 340 350
....*....|....*....|....*....|....
gi 446362813 335 LGAILLGVVSQMFGYRILFSGSAISALTALIIFV 368
Cdd:cd17370 338 LASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-379 |
1.70e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 91.87 E-value: 1.70e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 13 TFAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLA 92
Cdd:COG2223 11 TLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 93 STIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSF 172
Cdd:COG2223 91 VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 173 -MAVLLSLMTKMPFTPQKEKGKIQLFE-------KSVLSITIVVFFLSFAYGGITTFLPLFASSI----DVNPGTFFLVY 240
Cdd:COG2223 171 vVAVLAWLFLRDPPAGAAAAAKASLRDqlealrdPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfglsAATAGLLAALF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 241 AIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVL-TISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRG 319
Cdd:COG2223 251 ALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLaLALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAG 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446362813 320 VANASFFTAFDLGIGLGAILLGVVSQMFG-YRILFSGSAISALTALIIFVFFVKQRLGKKE 379
Cdd:COG2223 331 AVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
25-370 |
5.10e-20 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 90.33 E-value: 5.10e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 25 LLVPTLPLFIKE-IGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRV 103
Cdd:cd17473 17 AIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 104 IHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQnYSFHGLFLLATLLSFMAVLLSLMTKM 183
Cdd:cd17473 97 LLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLLFLPE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 184 PFTPQKEKGKIQLFE------KSVLSITIVVFFLSFAYGGITTFLPLFASSIDVNP----GTFFLVYAIALTIVRPISGK 253
Cdd:cd17473 176 PARKSKSAASPGAATaaalpwKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSaaliGLALAIASLAGAIGALLFGR 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 254 LLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFFTAFDLGI 333
Cdd:cd17473 256 LKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQ 335
|
330 340 350
....*....|....*....|....*....|....*...
gi 446362813 334 GLGAILLGVVSQM-FGYRILFSGSAISALTALIIFVFF 370
Cdd:cd17473 336 FLSPLVLGPLVNLtGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
25-355 |
3.77e-19 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 87.63 E-value: 3.77e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 25 LLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVI 104
Cdd:cd17504 14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 105 HGVTWAVSTTAVGTaITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFMAVLLSLMTKMP 184
Cdd:cd17504 94 QGIGGAVFPLAFAL-VREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLIDLR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 185 ftpqkekgkiQLFEKSVLSITIVVFFLSFAYGGITTFLPLFASS--------IDVNPGTFFLVYAIALTIVRPISGKLLD 256
Cdd:cd17504 173 ----------LLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptgfglGITEAGLLLLPGALVMLIAGPLAGRLIA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 257 KYGEVFIILPALCITIIAIV-VLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFFTAFDLGIGL 335
Cdd:cd17504 243 RVGPRRVLLIGLVISAVGLLlLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAI 322
|
330 340
....*....|....*....|
gi 446362813 336 GAILLGVVSQMFGYRILFSG 355
Cdd:cd17504 323 GPAIAGAILTTYTVSITSGG 342
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
30-366 |
9.77e-19 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 86.86 E-value: 9.77e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 30 LPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIHGVTW 109
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 110 AVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFMAVLLSLMTKMpftpqk 189
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLLDL------ 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 190 ekgkiQLFEKSVLSI-TIVVFFLSFAYGGITTFLPLFASSI----DVNPGTFFLVYAIALTIVRPISGKLLDKYGEVFII 264
Cdd:cd17503 173 -----RLFKDRNFTLgLLLSFLLGLGLFGAMFLLPLYLQNVlgysAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 265 LPALCITIIAIVVLTISNNLIGV---VIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFFT----AFDLGIGLGA 337
Cdd:cd17503 248 LAGLLLLALGTLLLAFLTPDTSLwliILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTirqlGGSIGTALLA 327
|
330 340
....*....|....*....|....*....
gi 446362813 338 ILLGVVSQMFGYRILFSGSAISALTALII 366
Cdd:cd17503 328 TLLTNRTQFHHSRLSELLAQQVQKQALII 356
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
15-374 |
1.53e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 86.06 E-value: 1.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 15 AMLFLFTGFY--LLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLA 92
Cdd:COG0738 14 YLLFFLWGFAtaLWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 93 STIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGeGMGWYGMAMTIAMAIGPMIGLAVVQ---NYSFHGLFLLATL 169
Cdd:COG0738 94 PSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAS-RLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPYLILAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 170 LSFMAVLLSLMTKMPFTPQKEKGKIQLFE--------KSVLSITIVVFFLSFAYGGITTFLPLFASSI----DVNPGTFF 237
Cdd:COG0738 173 LLLLLALLFLRSKLPEIEEEEEEAAGSAAslksllknPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVlglsEATAALGL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 238 LVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVdPSK 317
Cdd:COG0738 253 SLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGL-GKR 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 446362813 318 RGVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVFFVKQR 374
Cdd:COG0738 332 TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKR 388
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
13-369 |
3.97e-18 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 84.96 E-value: 3.97e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 13 TFAMLFLFTGFYLLVPTLPLFIKEI-GGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNL 91
Cdd:cd17472 2 SLIFSLRMLGMFLVLPVLSVYAKSLpGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 92 ASTIVLLAVLRVIHGvTWAVSTtAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLS 171
Cdd:cd17472 82 ATSIYGLILGRALQG-SGAISS-VVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 172 FMAVLLsLMTKMPFTP--------QKEKGKIQLFEKSVLSITIVVFFLSFAYGGITTFLPLFASSIDVNPGTFFLVYAIA 243
Cdd:cd17472 160 LVSLLI-LLFFVPDPPkivqisekEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 244 LT---IVRPISGKLLDKYGEVFIILPALCITIIA--IVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKR 318
Cdd:cd17472 239 ILigfILMVPFVIYAEKKGKMKQVFVSSILLIAVgfLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYR 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 446362813 319 GVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVF 369
Cdd:cd17472 319 GTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSFL 369
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
21-319 |
2.04e-17 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 82.68 E-value: 2.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 21 TGFYLLVPTLPLFIKEIGGNESQV----GLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIV 96
Cdd:cd17388 13 MGIGLIMPVLPTLLREFVGDSADAathyGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLW 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 97 LLAVLRVIHGVTWAVSTTAvGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGlAVVQNYSFHGLFLLATLLSFMAVL 176
Cdd:cd17388 93 WLYLGRIIAGITGATGAVA-AAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALG-GLLGEISPRAPFLVAAGLNGLNFL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 177 LSLMTkMPFTPQKEKGK-------------IQLFEKSVLSITIVVFFLSFAYGGIT-TFLPLF--------ASSIDVNPG 234
Cdd:cd17388 171 LGLFV-LPESLPPERRRafrwrranpfgslRWLTGFPGLLGLLAVFFLIQLIGQVPaTTWVLFtedrfdwsPTMVGLSLA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 235 TFFLVYAIALTIV-RPISGKLldkyGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGfGSAQPALQAAMLTIV 313
Cdd:cd17388 250 VFGLLHALFQAFVtGPIAKRL----GEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALG-GIAGPALQGLLSRQV 324
|
....*.
gi 446362813 314 DPSKRG 319
Cdd:cd17388 325 PENEQG 330
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-381 |
3.96e-17 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 82.26 E-value: 3.96e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 1 MERLWTKSFIQMTFAMLFLFTGFYLLVPTLPLFIKEIGG-NESQVGLMMGMFTIAAVVIRPIIGGMLDQYG-----RRSF 74
Cdd:COG2211 4 KKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGlSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPW 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 75 IIFGLIFFGLTMY------SYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSR-RGEGMGWYGMAMTIAMAIG 147
Cdd:COG2211 84 ILIGAIPLALSFVllftapDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGGLLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 148 PMIGLAVVQNYS------FHGLFLLATLLSFMAVLLS-LMTKMPFTPQKEKGKIQLFEKSVLS------ITIVVFFLSFA 214
Cdd:COG2211 164 SVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTfFGTKERPVPEEEKVSLKESLKALLKnrpfllLLLAYLLFFLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 215 YGGITTFLPLFASSIDVNP----GTFFLVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTIS--NNLIGVV 288
Cdd:COG2211 244 LALVAALLLYYFKYVLGLSaalvGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 289 IAATLYGVGFGSAQPALQAAMLTIVDPS--KRGVANASFFTAFD-----LGIGLGAILLGVVSQMFGYR----------- 350
Cdd:COG2211 324 VLAALAGIGLGAILVLPWAMLADVVDYDewKTGRRREGLYFGIFtfaikLGQALAGALAGLLLALFGYVagaaqspsalt 403
|
410 420 430
....*....|....*....|....*....|..
gi 446362813 351 -ILFSGSAISALTALIIFVFFVKQRLGKKEFA 381
Cdd:COG2211 404 gIRLLFFLLPAVLLLLAALLLLFYPLTRERHA 435
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
15-368 |
9.36e-17 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 80.67 E-value: 9.36e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 15 AMLFLFTGFYLLVPTLPLF-IKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQ-YGRRSFIIFGLIFFGLTMYSY-NL 91
Cdd:cd17471 4 ATLLTGLAGAFVLPYLSLFlTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFaFL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 92 ASTIVLLAVLRVIHGVTWAVS--TTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATL 169
Cdd:cd17471 84 RNYWVLLLVGVVLLSLGAAAFpqLFALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 170 LSFMAVLLSLMTKMPFTPQKEKGKIQLFEKSVLSI-TIVVFFLSFAYGGITTF-----LPLFASS-IDVNPGTFFLVYAI 242
Cdd:cd17471 164 LYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNrRLLLLFAAFTLLFAANSmyiiaMPLYVTNeLGGSESWVGLLFGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 243 ALTIVRPI---SGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIA----ATLYGVGFGSAQPALQAAMltivdP 315
Cdd:cd17471 244 AAALEIPImllAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALqllnAIFIGITAGLGISYFQDLM-----P 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446362813 316 SKRGVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFV 368
Cdd:cd17471 319 GQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
17-366 |
2.11e-16 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 79.93 E-value: 2.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 17 LFLFTGFY---LLVPTLPLFIKE-IGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLA 92
Cdd:PRK05122 22 MFTFISYLtigLPLAVLPGYVHDqLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALSGLLYLLA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 93 S--------TIVLLAVLRVIHGvtWAVSTTAVGTAITDI--IPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHG 162
Cdd:PRK05122 102 GllaawpvlSLLLLLLGRLLLG--IGESLAGTGSILWGIgrVGALHTGRVISWNGIATYGALAIGAPLGVLLYHWGGLAG 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 163 LFLLATLLSFMAVLLSL-MTKMPFTPQKEKGKIQLFEKsVLSITIVVFFLSFAYGGITTFLPLFASSIDVNPGTFFL-VY 240
Cdd:PRK05122 180 LGLLIMLLALLGLLLARpRPAVPPVKGERLPFRRVLGR-VWPYGMGLALASIGFGTIATFITLYYAARGWDGAALALtLF 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 241 AIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGV 320
Cdd:PRK05122 259 GVAFVGARLLFGNLINRLGGLRVAIVSLLVEILGLLLLWLAPSPWMALIGAALTGFGFSLVFPALGVEAVKRVPPQNRGA 338
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 446362813 321 ANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALII 366
Cdd:PRK05122 339 ALGAYSVFLDLSLGITGPLAGLVASWFGYPSIFLAAALAALLGLAL 384
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-368 |
6.19e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 78.24 E-value: 6.19e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 12 MTFAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNL 91
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 92 ASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQN--YSFHGLFLLATL 169
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 170 LSFMAVLLSLMTKMPFTPQKEKGKIQLFEKS-------------VLSITIVVFFLSFAYGGITTFLPLFASSI----DVN 232
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSvlkllkrvlknpgLWLLLLAIFLVNLAYYSFSTLLPLFLLDLgglsVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 233 PGTFFLVYAIALTIVRPISGKLLDKYGEVFIILPALCI-TIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLT 311
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLlMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446362813 312 IVDPSKRGVANASFFTAFDLGIGLGAILLGVV-SQMFGYRILFSGSAISALTALIIFV 368
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
17-372 |
2.09e-15 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 76.85 E-value: 2.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 17 LFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMY-SYNLASTI 95
Cdd:cd17335 7 FFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFlSLFFVAQI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 96 -VLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEG----MGWYGMAMTiAMAIGPMIGLAvVQNYSFHGLFLLATLL 170
Cdd:cd17335 87 fWLLLLLVILGAFFSAPVVPLVDSITLQYLGEERERYGkqrlWGSIGFGIA-ALLVGILIDRS-STYKNYTIAFYVFAVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 171 SFMAVLLSLMTKMPFTPQKE-----KGKIQLFEKSVLSITIVVFFLSFAYGGITTFLPLFASSIDVNP---GTFFLVYAI 242
Cdd:cd17335 165 MLLALLLALKFPFRPKHPEPnentgGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKtliGLLWTVGVV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 243 ALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVAN 322
Cdd:cd17335 245 SEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQ 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 446362813 323 ASFF-TAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVFFVK 372
Cdd:cd17335 325 GLLQgLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
17-371 |
6.56e-15 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 75.34 E-value: 6.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 17 LFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRS-FIIFGLIFFGLTMYSYNLASTI 95
Cdd:cd17490 6 FLFWFSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKlFIIIGLLFTVLASLIMILFPSP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 96 VLLAVLRVIHGV---TWAVSTTAvgtaITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSF 172
Cdd:cd17490 86 WGLLIARFLSGIaaaTWVSFTVL----YASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 173 MAVLLSLMTK------MPFTPQKEKGKIQLFEKSVLSITIVVFFLSFA-YGGITTFLPLFAS-------SIDVNPGTFFL 238
Cdd:cd17490 162 LGFILSLFIKeerrekKPVLTELKELLSVLKDKKLLFFSLLAILQQMItFSTTFGFTPLIAKqlgassfQLGLLSIIYLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 239 VYAIALTIVRPISGKlldKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKR 318
Cdd:cd17490 242 PNALASLLSGTLFYK---KLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQR 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446362813 319 GVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVFFV 371
Cdd:cd17490 319 STAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
16-371 |
2.24e-14 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 73.76 E-value: 2.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 16 MLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTI 95
Cdd:cd17320 8 VALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 96 VLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFMAV 175
Cdd:cd17320 88 EQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 176 LLSLMtKMPFTPQKEKGKIQ-----------LFEKSVLS---ITIVVFFLSFAYGGITTFlpLFASSIDVNPGTF---FL 238
Cdd:cd17320 168 LLVLL-FLPETLPEEKRKPLlssllraykrvLKNRRFLGyalALGLSFAGLFAYLAAAPF--IYIEQLGLSPAQFgllFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 239 VYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVL-----TISNNLIGVVIAATLYGVGFGSAQPALQAAMLTiV 313
Cdd:cd17320 245 LNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLllaalLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALE-P 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446362813 314 DPSKRGVANASFFTafdLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVFFV 371
Cdd:cd17320 324 FPHVAGTASALLGF---LQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLIL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
204-372 |
8.32e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 71.84 E-value: 8.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 204 ITIVVFFLSFAYGGITTFLPLFASSIDVNP---GTFFLVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTI 280
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVaqiGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 281 SNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISA 360
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170
....*....|..
gi 446362813 361 LTALIIFVFFVK 372
Cdd:cd17325 161 LLALVLALLLLP 172
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
42-325 |
3.06e-13 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 69.90 E-value: 3.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 42 SQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAIT 121
Cdd:cd17502 30 SLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 122 DIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLS-FMAVLLSlmtkmpftpqkekgkiqlfekS 200
Cdd:cd17502 110 DLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGgLALALLR---------------------T 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 201 VLSITIVVFFLSFAYGGITTFLPLFASSI----DVNPGTFFLVYAIALTIVRPISGKLLDKYG-EVFIILPALCITIIAI 275
Cdd:cd17502 169 ILLSSIFGFLFGGALFGLIYYLPLYFQLVlgdsATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVIGTILMSVGA 248
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 446362813 276 VVLTI---SNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASF 325
Cdd:cd17502 249 GLLTTltlDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATN 301
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
199-372 |
3.37e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 70.00 E-value: 3.37e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 199 KSVLSITIVVFFLSFAYGGITTFLPLFASSIDVNP---GTFFLVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAI 275
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPaqaGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 276 VVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSG 355
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170
....*....|....*..
gi 446362813 356 SAISALTALIIFVFFVK 372
Cdd:COG2814 170 NAVLALLALLLLLRLLP 186
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
21-376 |
3.38e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 67.21 E-value: 3.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 21 TGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAV 100
Cdd:COG2807 32 PAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 101 LRVIHGVTWAVSTTAVGTAITDIIPDsRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFMAVLLSLM 180
Cdd:COG2807 112 GTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLP 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 181 ----TKMPFTPQKEKGKIQLFEKSVLSITIVVFFL--SFAYGGITTFLPLFASSIDVNP---GTFFLVYAIALTIVRPIS 251
Cdd:COG2807 191 llrrRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGlqSLLYYAVVAWLPPILRDAGLSAataGLLLSLFQLAGIPGSLLV 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 252 GKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQP-ALQAAMLTIVDPSKRGVANASFFTAFD 330
Cdd:COG2807 271 PLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPlALTLIGLRARTPAEAAALSGMAQSVGY 350
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446362813 331 LGIGLGAILLGVVSQMFG-YRILFSGSAISALTALIIFVFFVKQRLG 376
Cdd:COG2807 351 LLAALGPLLVGALHDATGsWTAALLLLAALAVLMLVAGLLAGRPYVE 397
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
30-369 |
7.40e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 66.05 E-value: 7.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 30 LPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIHGVTW 109
Cdd:cd17319 26 APTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 110 AVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFMAVLLSLmtkmpftpqk 189
Cdd:cd17319 106 AGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWW---------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 190 ekgkiqLFEKSVLSITIVVFFLSFAYGGITTFLPLFASSI----DVNPGTFFLVYAIALTIVRPISGKLLDKY---GEVF 262
Cdd:cd17319 176 ------FYLRQVWGLALGYFGINYALYGLLTWLPTYLKQArgfsLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 263 IILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFFTAFDLGIGLGAILLGV 342
Cdd:cd17319 250 VIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGY 329
|
330 340
....*....|....*....|....*...
gi 446362813 343 VSQMFG-YRILFSGSAISALTALIIFVF 369
Cdd:cd17319 330 LVDATGsYTAAFLFLAAVALLAALLVLL 357
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
12-247 |
9.00e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 65.22 E-value: 9.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 12 MTFAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNL 91
Cdd:COG0477 19 LALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 92 ASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLS 171
Cdd:COG0477 99 APSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLG 178
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446362813 172 FMAVLLSLMTKMPFTPQKEKGKIQLFEKSVLSITIVVFFLSFAYGGITTFLPLFASSIDVNPGTFFLVYAIALTIV 247
Cdd:COG0477 179 LLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLL 254
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
5-353 |
3.36e-11 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 64.17 E-value: 3.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 5 WTKSFIQMTFAMLFLFTGFYLLVPTLPLFIKEIGGNESQV-----GLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGL 79
Cdd:PRK09874 12 WKRNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSAlnmwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 80 IFFGLTMYSYNLASTIVLLAVLRVIHGVTWAVSTTAvGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYS 159
Cdd:PRK09874 92 LGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNA-NALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 160 FHGLFLLATLLSFMAVLLSLM-TKMPFTPQKEKGKIQLFE--------KSVLSITIVVFFLSFAYGGITTFLPLF----- 225
Cdd:PRK09874 171 LRPVFFITASVLFLCFLVTLFcIRENFQPVSKKEMLHMREvvtslknpKLVLSLFVTTLIIQVATGSIAPILTLYvrela 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 226 --ASSIDVNPGTFFLVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQP 303
Cdd:PRK09874 251 gnVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLP 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 446362813 304 ALQaAMLTIVDPSKRGVANASFFTAF-DLGIGLGAILLGVVSQMFGYRILF 353
Cdd:PRK09874 331 AVQ-TLLVYNSSNQIAGRIFSYNQSFrDIGNVTGPLMGAAISANYGFRAVF 380
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
9-181 |
6.86e-11 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 63.05 E-value: 6.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 9 FIQMTFAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFT----IAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGL 84
Cdd:cd17391 203 LISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFsatgVSSLLSAPRLGKLGDRIGHHRILLGALLASAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 85 TMYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLF 164
Cdd:cd17391 283 LYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVF 362
|
170
....*....|....*..
gi 446362813 165 LLATLLSFMAVLLSLMT 181
Cdd:cd17391 363 VVTALLVLLNAIWSFIF 379
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
24-361 |
8.03e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.02 E-value: 8.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 24 YLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRV 103
Cdd:cd17328 16 FTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 104 IHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQ-NYSFHGLFLLATLLSFMAVLLSLMTK 182
Cdd:cd17328 96 LVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVTGVLGVLLAILLLLFV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 183 MPFTPQKEKG---------------KIQLFEKSVLSITIVVFFLSFAYGGITTFLPLF-----------ASSIDVNPGTF 236
Cdd:cd17328 176 REPPRGAAEGgvmakstatsfladlKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFflrafgvgdlsSADVGLIFGAI 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 237 FLVYAIALTIVRPISGKLLDKY---GEVFIILPALCITIIAIVVLTISNNLIGVVIAATLY-GVGFGSAQPALQAAM-LT 311
Cdd:cd17328 256 TCIAGVLGVLLGGILADRLRRKtprADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFlGEFLLSLNWAPVFAIlLY 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 446362813 312 IVDPSKRGVANASF-FTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISAL 361
Cdd:cd17328 336 VVIPTRRSTASAIQiLLSHLLGDAGSPYLIGLISDLLRQNKDSPLAEAASL 386
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
17-353 |
1.24e-10 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 62.26 E-value: 1.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 17 LFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFII----FGLIFFGLTMYSYNLA 92
Cdd:pfam12832 9 FFYFAALGCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVrlasILAAVLFLSVLFIPIS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 93 STIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEG----MGWYGMAmTIAMAIGPMIGLAVVQnysFHGLFLLAT 168
Cdd:pfam12832 89 LTFWWLALLVVLFSFFWNAILPQFEVATLQHLGEKRKDYGrqrlWGSVGFA-LSVFGLGALFDHYSVG---LLPSVLFYL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 169 LLSFMAVLLSLMTKMPFTPQKEKGKIQ------LFEKSVLSITIVVFFLSFAYGGITTFLPLFASSIDVNP---GTFFLV 239
Cdd:pfam12832 165 FAALMLLSLLLPLAPPEMEYESKGGSKavfwnlLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENLGASNtllGALWAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 240 YAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVL-TISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKR 318
Cdd:pfam12832 245 GVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYaFFVENPWLVLPIQFLHAISFGLTHAAAIEYVRRIFPGSLQ 324
|
330 340 350
....*....|....*....|....*....|....*.
gi 446362813 319 GVANASFFTA-FDLGIGLGAILLGVVSQMFGYRILF 353
Cdd:pfam12832 325 GTGQALYSGLyFGLGGALGSLIGGQLWDLFGARFTF 360
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
14-179 |
3.72e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 60.66 E-value: 3.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 14 FAMLFLFTGFYLLVPTLPLFIKEIG-GNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLA 92
Cdd:cd17473 204 FLAFLAMLLFYVIPIQLPFLLQERGgGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALA 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 93 STIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGP-MIGLAVVQNYSFHGLFLLATLLS 171
Cdd:cd17473 284 SGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPlVLGPLVNLTGGLSGAFLILGVLA 363
|
....*...
gi 446362813 172 FMAVLLSL 179
Cdd:cd17473 364 LVLAIVLL 371
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
7-179 |
3.85e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 60.70 E-value: 3.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 7 KSFIQMTFAMLFLFTGFYLLVPTLPLFIKEIGGN-ESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLT 85
Cdd:cd17329 200 RAFLLFLLASFLISLIYFQLESTLPVYVVEILGLgESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIG 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 86 MYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFL 165
Cdd:cd17329 280 FAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWL 359
|
170
....*....|....
gi 446362813 166 LATLLSFMAVLLSL 179
Cdd:cd17329 360 ILAALGLIAAALLL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-146 |
1.02e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 59.22 E-value: 1.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 4 LWTKSFIQMTFAMLFLFTGFYLLVPTLPLFIKEIGG-NESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFF 82
Cdd:COG2814 204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGlSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446362813 83 GLTMYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAI 146
Cdd:COG2814 284 ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
22-180 |
1.04e-09 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 59.16 E-value: 1.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 22 GFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVL 101
Cdd:cd17390 11 GVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 102 RVIHGVTWAVSTTAvGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIG--LAVVQNYSFHGLFLLATLLSFMAVLLSL 179
Cdd:cd17390 91 RIPLGIFKHTQSLC-KAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGghLAETDGGFYYVALLCSAIFILNAGLVWF 169
|
.
gi 446362813 180 M 180
Cdd:cd17390 170 L 170
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
27-281 |
1.05e-09 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 59.54 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 27 VPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIHG 106
Cdd:PRK11102 11 LPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 107 VTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFMAVLLsLMTKMPFT 186
Cdd:PRK11102 91 LAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAAL-VFFFIPET 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 187 PQKEKGK-----------IQLF-EKSVLSItivVFFLSFAYGGITTFLP--------LFASSIDvNPGTFFLVYAIALTI 246
Cdd:PRK11102 170 LPKERRQpfhlrttirnfASLFrHKRVLGY---MLASGFSFAGMFSFLTagpfvyieLNGVSPQ-NFGYYFALNIVFLFV 245
|
250 260 270
....*....|....*....|....*....|....*
gi 446362813 247 VRPISGKLLDKYGEVFIILPALCITIIAIVVLTIS 281
Cdd:PRK11102 246 MTIINSRFVRRVGALNMLRFGLWIQFIMGIWLVVS 280
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
9-367 |
1.22e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 59.17 E-value: 1.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 9 FIQMTFAMlflftgFYLLVPTLPLFIKE-IGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMY 87
Cdd:cd17475 3 LAQAAASL------VAQGIPALAPFLQEdLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 88 SYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLA 167
Cdd:cd17475 77 LMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 168 TLLS-FMAVLLSLMTKMPFTPQKEKGKIQ---------LFEKSVLSITIVVFFLSFAYGGITTFLPLFASS---IDVNPG 234
Cdd:cd17475 157 GLVSiLAAVLFWLFYREPPAASAATESAStllrslkevLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDhlgLSVVAA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 235 TFFLVYAIALTIV-RPISGKLLDKYGE-----VFIILPALC-ITIIAIVVLTISNNLIGVVIAATLYGVgFGSAQPALQA 307
Cdd:cd17475 237 GALLAVAQLGGALgRIGLGRVSDRVFGgrrrpVLVITAAIAaAALLVLSLLSPGTPLWLLVLLLILLGL-FAIGWNGLYL 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446362813 308 AMLT-IVDPSKRGVANASFFTAFDLGIGLGAILLG-VVSQMFGYRILFSGSAISALTALIIF 367
Cdd:cd17475 316 TLVAeSAGPEQAGTALGLANTINFIGIAIGPPLFGlLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-184 |
2.48e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 58.34 E-value: 2.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 8 SFIQMTFAMLFLFTGFYLLVPTLPLFIKEIGG-NESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRS--FIIFGLIFFGL 84
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGlSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 85 TMYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLF 164
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
|
170 180
....*....|....*....|
gi 446362813 165 LLATLLSFMAVLLSLMTKMP 184
Cdd:COG2271 341 LLLAALALLAALLALLLLRE 360
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
30-209 |
3.03e-09 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 58.54 E-value: 3.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 30 LPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIHGVTW 109
Cdd:TIGR00711 25 IPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 110 AVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFMAVLLSLMTkMPFTPQK 189
Cdd:TIGR00711 105 GPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFI-LPRDKPA 183
|
170 180
....*....|....*....|
gi 446362813 190 EKGKIQLFEKSVLSITIVVF 209
Cdd:TIGR00711 184 ASENFDFLGLLLLSVGLGSL 203
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
6-177 |
7.92e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.81 E-value: 7.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 6 TKSFIQMTFAMLFLFTGFYLLVPTLPLFIK-EIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQ-YGRRSFIIFGLIFFG 83
Cdd:cd17474 197 GRGLLTFLVSAFLYFFLYFAFLTYLPFLLElLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 84 LTMYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGL 163
Cdd:cd17474 277 LSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAP 356
|
170
....*....|....
gi 446362813 164 FLLATLLSFMAVLL 177
Cdd:cd17474 357 FLVGAAIALAAAVL 370
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
14-177 |
1.26e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.01 E-value: 1.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 14 FAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLAS 93
Cdd:cd17370 206 LLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGS 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 94 TIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFM 173
Cdd:cd17370 286 SLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALI 365
|
....
gi 446362813 174 AVLL 177
Cdd:cd17370 366 ALLL 369
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
15-370 |
2.39e-08 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 55.34 E-value: 2.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 15 AMLFLFTGFYL--LVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLA 92
Cdd:cd17393 5 AAFFFINGILMasWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 93 STIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGM----AMTIAMAIGPMIGLAVVQNYSFHGLFLLAT 168
Cdd:cd17393 85 PSVPALALALFLFGAANGALDVAMNAQGVAVERAYGRPIMSSLHAMwslgGLAGALLGAAAIGAGVSPGVHLLAAAVLLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 169 LLSFMAV--LLSLMTKMPFTPQKEKGKIQLF--EKSVLSITIVVFFLSFAYGGITTFLPLFASSIDVNP----GTFFLVY 240
Cdd:cd17393 165 LAALVAIraLLPGTGEAAEDRPDGAGKPGFLlpNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASaalaALGYAVF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 241 AIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQP-ALQAAMLTIVDPSKRG 319
Cdd:cd17393 245 SLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPlAFSAAGALPGLAAGIA 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 446362813 320 VANASFFTAfdLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVFF 370
Cdd:cd17393 325 VARVATLGY--LGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLARAV 373
|
|
| MFS_MFSD6L |
cd17479 |
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ... |
26-368 |
2.78e-08 |
|
Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341032 [Multi-domain] Cd Length: 376 Bit Score: 55.01 E-value: 2.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 26 LVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLrVIH 105
Cdd:cd17479 15 LLPFLTLYFRQLGLTAPQVGIIIGSKHLISLLWAPFWSFLAKSYRKRRFVILFSLLISLGTYLLYHQIFLLVLLVI-IIW 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 106 GVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQN-----------YSFHglFLLATLLSFMA 174
Cdd:cd17479 94 ELLSAPLEKVADDSLYEYLDFVDATERYGKLKVWSALGAAFGPCGITLLVDNldcflppkisrILLH--FYTYGGFMILT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 175 VLLSLMTKMPFTPQKEKG-------KIQLFEKSVLSITIVVFFLSFAYGGITTFLPLFASSIDVNPGTFFLVYAIAL--- 244
Cdd:cd17479 172 FLLSFFYPIPVPKKEEHSskvvkglRLLGGDGRAILYALTVFLVGFVGSTVQNFLFWLMQDKGGSELHMGLSIALALlse 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 245 TIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANAS 324
Cdd:cd17479 252 ILMSFFGNWLLRKLGHAGCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALWWAVNSQVEFLASPGMERSLQLV 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 446362813 325 FFT-AFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFV 368
Cdd:cd17479 332 LRAlYYGIGFALGSFVSGFIYDRFGLAILYQACCVVLGLWLIIFA 376
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
201-372 |
3.07e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 54.89 E-value: 3.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 201 VLSITIVVFFLSFA-YGGITTFLPLFASSIDVNPGTFFLVYAIAL---TIVRPISGKLLDKYGEVFIILPALCITIIAIV 276
Cdd:COG2223 6 VLLLATLAFFLAFGvWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVlvgALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 277 VLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGS 356
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170
....*....|....*.
gi 446362813 357 AISALTALIIFVFFVK 372
Cdd:COG2223 166 GILLLVVAVLAWLFLR 181
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
21-368 |
3.53e-08 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 54.92 E-value: 3.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 21 TGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAV 100
Cdd:cd17331 14 TCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 101 LRV----IHGVTwavsttAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFMAVL 176
Cdd:cd17331 94 SRLpsvfMHAMQ------AAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 177 LSLM----------TKMPFTPQKEKGKIQLFE-------KSVLSITIVVFFLSFAYGGITTFLPLFASS---IDVNPGTF 236
Cdd:cd17331 168 LVILlipsntkskrEKEAKESASPPSVFNLKEilrllrlPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDffgLTPEENGY 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 237 FLVYAIALTIVRP--ISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVD 314
Cdd:cd17331 248 LMSYAGVLGMVVQglLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVP 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446362813 315 PSKRGVANASFFTAFDLGIGLGAILLGVVSQMFGYRIL-FSGSAISALTALIIFV 368
Cdd:cd17331 328 PEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFgLLGAAINGLLTVYLLL 382
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
222-378 |
4.24e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 54.48 E-value: 4.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 222 LPLFASSIDVNPGTFFL---VYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGF 298
Cdd:cd17324 22 LPDIARDFGVSVAQAGLlvsAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 299 GSAQPALQAAMLTIVDPSKRGVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVFFVKQRLGKK 378
Cdd:cd17324 102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
30-343 |
8.61e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 53.51 E-value: 8.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 30 LPLFIKEIGGNESQVGlMMGMFTIAAVVIRPIIGGML-DQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIHGVT 108
Cdd:TIGR00895 40 APAISAEWGLDPVQLG-FLFSAGLIGMAFGALFFGPLaDRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 109 WAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLS-FMAVLL---------- 177
Cdd:TIGR00895 119 LGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPlLLLLLLmrflpesidf 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 178 --------------------------SLMTKMPFTPQKEKGKIQLFEKSVLSITIVV----FFLSFAYGGITTFLPLFAS 227
Cdd:TIGR00895 199 lvskrpetvrrivnaiapqmqaeaqsALPEQKSTQGTKRSVFKALFQGKTARITVLLwllyFMLLVGVYFLTNWLPKLMV 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 228 SIDVNP---GTFFLVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPA 304
Cdd:TIGR00895 279 ELGFSLslaATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSG 358
|
330 340 350
....*....|....*....|....*....|....*....
gi 446362813 305 LQAAMLTIVDPSKRGVANASFFTAFDLGIGLGAILLGVV 343
Cdd:TIGR00895 359 LYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
30-353 |
9.51e-08 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 53.53 E-value: 9.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 30 LPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIHGVTW 109
Cdd:TIGR00881 18 MPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 110 AVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMI-GLAVVQNYSFHGLFLLATLLS--FMAVLLSLMTKMPFT 186
Cdd:TIGR00881 98 GMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLvLFGIAELYSWHWVFIVPGIIAiiVSLICFLLLRDSPQS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 187 P------------------------QKEKGKIQ--LFEKSVLSITIVVFFLSFAYGGITTFLPLFASSID----VNPGTF 236
Cdd:TIGR00881 178 CglppaeempneepdgdaekkeeelTKKQIFLQyvLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKgfskEKASWA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 237 FLVYAIALTIVRPISGKLLDKY--GEVFII-LPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIV 313
Cdd:TIGR00881 258 FTLYELGGLVGTLLAGWLSDKLfnGRRGPLaVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIASE 337
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 446362813 314 DPSKRGVANASFFTAFDLGIG--LGAILLGVVSQMFGYRILF 353
Cdd:TIGR00881 338 LAPKKAAGTAAGFVGFFAYLGgiLAGLPLGYLADGFGWAGAF 379
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
28-179 |
1.19e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 52.96 E-value: 1.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 28 PTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIHGV 107
Cdd:cd17323 20 PALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGF 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446362813 108 TWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFMAVLLSL 179
Cdd:cd17323 100 FGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIF 171
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
30-369 |
2.22e-07 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 52.24 E-value: 2.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 30 LPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLD----QYGRR-SFIIFGLIF-------------FGLTMYSYNL 91
Cdd:cd17313 22 VPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDrcnsRIGRRrPFILVGAPLaalglilipnaadIGLALGDGPR 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 92 ASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIG----------LAVVQNYSFH 161
Cdd:cd17313 102 TWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGailwdhnwfgFALGGNLKVP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 162 GLFLLATLLSFMAVLLSLMTKMPFTPQKE------------KGKIQLF---EKSVLSITIVVFFLSFAYGGITTFLPLFA 226
Cdd:cd17313 182 FYIGAIILLVCVLVTLFFVKEPPLSPEAGehsenpslgevlKSLLKLLkimPRSLLRLLLVIFFWWIAFFPFELFFTDYM 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 227 S--------------SIDVNPGTFFL-VYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAA 291
Cdd:cd17313 262 GeevyhgtsaasshyGAGVRMGAWGLlIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLF 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 292 TLYGVGFGSAQpALQAAMLTIVDPSKR---GVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFV 368
Cdd:cd17313 342 ALGGIGWATIN-INPYPLVSDYHSESGrgqGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGAL 420
|
.
gi 446362813 369 F 369
Cdd:cd17313 421 F 421
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
204-378 |
2.55e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 52.04 E-value: 2.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 204 ITIVVFFLSFAYGGITTFLPLF-ASSIDVNPGTF---FLVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLT 279
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLlAEDLGISPTEIgllLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 280 ISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAIS 359
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|....*....
gi 446362813 360 ALTALIIFVFFVKQRLGKK 378
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKR 179
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
6-190 |
4.45e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 51.42 E-value: 4.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 6 TKSFIQMTFAMLFLFTGFYLLVPTLPLFIKEIGGNE-SQVGLMMGMFTIAAVVIRPIIGGMLDQYGRR-----SFIIFGL 79
Cdd:COG2223 204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSaATAGLLAALFALLGALGRPLGGWLSDRIGGRrvlliVFALMAL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 80 IFFGLTMYSYNLASTIVLLAVLrvihGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNY- 158
Cdd:COG2223 284 GLLLLALALGSLWLFLVLFLLL----GLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATg 359
|
170 180 190
....*....|....*....|....*....|..
gi 446362813 159 SFHGLFLLATLLSFMAVLLSLMTKMPFTPQKE 190
Cdd:COG2223 360 SYTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
234-379 |
5.69e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.07 E-value: 5.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 234 GTFFLVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIV 313
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVT 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446362813 314 DPSKRGVANASFFTAFDLGIGLGAILLGVVSqMFGYRILFSGSAISALTALIIFVFFVKQRLGKKE 379
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRR 182
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
206-372 |
6.95e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 50.65 E-value: 6.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 206 IVVFFLSFAYGGITTFLPLFASSIDVNPGTFFLV------YAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLT 279
Cdd:cd17330 3 LVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVgllqssYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 280 ISNNLIGVVIAATLYGVgFGSAQPALQAAMLTIVDPSKRGVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAIS 359
Cdd:cd17330 83 LSRNLWLLFLARFLDGL-TGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAAL 161
|
170
....*....|...
gi 446362813 360 ALTALIIFVFFVK 372
Cdd:cd17330 162 ALLNLVLVLFFLP 174
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
6-182 |
1.81e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 49.50 E-value: 1.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 6 TKSFIQMTFAMLFLFTGFYLLVPTLPLFIKEIGG-NESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGL 84
Cdd:cd17503 177 DRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGySAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLAL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 85 TMYS---YNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNY--- 158
Cdd:cd17503 257 GTLLlafLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRtqf 336
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 446362813 159 --------------------SFHGLFLLATLLSFMAVLLSLMTK 182
Cdd:cd17503 337 hhsrlsellaqqvqkqaliiAFNDAFLVSAILLLVGLLLALFLR 380
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
204-368 |
2.12e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.09 E-value: 2.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 204 ITIVVFFLSFAYGGITTFLPLFASSIDVNPGTFFLV---YAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTI 280
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVasaYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 281 SNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFFTAFDLGIGLGAILLGVVSQMfGYRILFSGSAISA 360
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GALPFLIAAVLLL 159
|
....*...
gi 446362813 361 LTALIIFV 368
Cdd:cd17477 160 LALVPLLL 167
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
29-339 |
2.34e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 49.12 E-value: 2.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 29 TLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIHGVT 108
Cdd:cd17365 21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 109 WAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFMAVLLSLMTkmpftpq 188
Cdd:cd17365 101 LGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGT------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 189 kekgkiqlfeksvLSITIVVFFLSFAYGGITTFLPLFASSIDVNPG---TFFLVYAIALTIVRPISGKLLDKYGEVFIIL 265
Cdd:cd17365 174 -------------LLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSqalTITLLLNIGGVIGSLLLGWLADRFGPKRVLA 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446362813 266 PALCITIIAIVVL-TISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVAnasffTAFDLGIG-LGAIL 339
Cdd:cd17365 241 LFFALGAVSLALLgVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATG-----VGWALGVGrLGAIL 311
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
9-370 |
2.56e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 48.81 E-value: 2.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 9 FIQMTFAMLFLFTGFYLLVPtlplFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYS 88
Cdd:cd17355 9 FLILILSWGIRYYFGVFIIP----IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 89 YNLASTIVLLAVLRVIHGVTWAVSTTAVGTA-ITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSF-HGLFLL 166
Cdd:cd17355 85 LALATSLWQLYLLWGLLGGGGAGTLAAVAFAtVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWrTALLVL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 167 ATLLSFMAVLLSLMTKMPFTPQKEKGKIQLFEKSVLS-------------ITIVVFFLSFAYGGITTFLPLFASSIDVNP 233
Cdd:cd17355 165 ALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGStlkealrsasfwlLALAFFLCGFAVVGLIVHLVPYLADRGISP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 234 GTFFLVYA---IALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLI-GVVIAATLYGVGFGSAQPALQAAM 309
Cdd:cd17355 245 AAAAVALAligLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPlALLLFAALFGLGWGATVPLTAALA 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446362813 310 LTIVDPSKRGVANASFFTAFDLGIGLGAILLGVVSQMFG-YRILFSGSAISALTALIIFVFF 370
Cdd:cd17355 325 ARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALLVLPI 386
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
201-376 |
2.61e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 48.65 E-value: 2.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 201 VLSITIVVFFLSFAYGGITTFLPLFASSIDVNP---GTFFLVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVV 277
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSaqlGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 278 LTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSA 357
Cdd:COG0477 96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINA 175
|
170
....*....|....*....
gi 446362813 358 ISALTALIIFVFFVKQRLG 376
Cdd:COG0477 176 PLGLLALVLRLRLPESRGL 194
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
4-182 |
3.05e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 48.71 E-value: 3.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 4 LWTKSFIQMTFAMLFLFTGFYLLVPTLPLFIKEIGG-NESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFF 82
Cdd:cd17321 165 LLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGySPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLT 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 83 GLTMYSY---NLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQN-- 157
Cdd:cd17321 245 AVGLLLLallGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAgl 324
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 446362813 158 ---------------------YSFHGLFLLATLLSFMAVLLSLMTK 182
Cdd:cd17321 325 sanlgdsgvaallsaaaaafaAGFHLAFLVAAALALLAALLALLLP 370
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
22-369 |
3.21e-06 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 48.82 E-value: 3.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 22 GFYLLVPTLPLFIKEIGGNESQVGLMMgMFTIAAVVIRPIIGGML-DQYGRRSFIIF-----GLIFFGLTMYSYNLASTI 95
Cdd:PRK10489 32 GLGLLGVAVPVQIQMMTGSTLQVGLSV-TLTGGAMFIGLMVGGVLaDRYDRKKLILLargtcGLGFIGLALNAFLPEPSL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 96 VLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFMAV 175
Cdd:PRK10489 111 LAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPALGGLLIAAGGVAWNYGLAAAGTFITL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 176 LLSL-MTKMPFTPQKEKGKIQ--------LFEKSVLSITIVVFFLSFAYGGITTFLPLFASSI-DVNPGTFFLVY-AIAL 244
Cdd:PRK10489 191 LPLLrLPALPPPPQPREHPLRsllagfrfLLASPVVGGIALLGGLLTMASAVRVLYPALADEVwQMGAAQIGLLYaAVPL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 245 --TIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQpALQAAMLTIVDPSK-RGVA 321
Cdd:PRK10489 271 gaALGALTSGWLAHSARPGLLMLLSTLGSFLAVGLFGLMPMWILAVLCLALFGYLSAISS-LLQYTLLQTQTPDEmLGRI 349
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 446362813 322 NaSFFTAFD-LGIGLGAILLGVVSQMFGYR--ILFSGSAISALTALIIFVF 369
Cdd:PRK10489 350 N-GLWTAQNvTGDAIGAALLGGLGAMMTPVasASASGFGLLIIGVLLLLVL 399
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
3-180 |
3.69e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 48.34 E-value: 3.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 3 RLWTKSFIQMTFAMLFLFTGFYLLVPTLPLFIKEIGG-NESQVGLMMGMFTIAAVVIRPIIGGMLDQY-GRRSFIIFGLI 80
Cdd:cd17330 170 LFFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGfSPSQIGLLLALVGIAGILAQLLLIPRLAKRlGERKLLRLGLL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 81 FFGLTMYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSF 160
Cdd:cd17330 250 LAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGP 329
|
170 180
....*....|....*....|
gi 446362813 161 HGLFLLATLLSFMAVLLSLM 180
Cdd:cd17330 330 GVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
23-374 |
3.69e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 48.45 E-value: 3.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 23 FYLLVPTLPLFIKEIGGNESQVGlMMGMFTIAAVVIRPIIGGML-DQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVL 101
Cdd:cd17371 15 LLLLGLVLPALIAEFGLDEAEAG-LLGTVTLAGGAIGGILGGILaDRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLIL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 102 RVIHGVTWAVSTTAVGTAITDIIPDSRRGEG-----MGWYGMAMTIAMAIGPMIGLAvVQNYSFHGLFLLATLLSFMAVL 176
Cdd:cd17371 94 RALAGLGFGGEWAAGAALMAEYVPARHRGKAlgyvqSGWAVGWLLATLLAALLFPLL-PPEIAWRVLFLLGALPALLVLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 177 LSLMTKMPFTPQKEKGKIQ----------LFEKSVLSITIVVFFLS----FAYGGITTFLPLFASS---IDVNPGTFFLV 239
Cdd:cd17371 173 IRRFVKEPPQWQAARAARRhfadrpslreLFSPPLLRTTLLASLLAtgalGGYYGITTWLPSYLTGergLSFEGSAGYLV 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 240 YAIALTIV-RPISGKLLDKYGEVFIILPALCITIIAIVV---LTISNNLIGVVIAATLYgvgFGSAQPALQAAMLTIVDP 315
Cdd:cd17371 253 VTILGGFLgYLAGGFLADRIGRRNNFALFALGSAISILLyffLPLSPTLILILGFPLGF---FASGPFSGMGAYLTELFP 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 316 SKRGVANASFFTAFDLGIG-LGAILLGVVSQMFGYRILFSGSAISALTALIIFVFFVKQR 374
Cdd:cd17371 330 TAVRATAQGFCYNVGRIIGaLFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPET 389
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
26-188 |
4.06e-06 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 48.38 E-value: 4.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 26 LVPTLPLFIKEIGGNESQVGLMMGMFT----IAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVL 101
Cdd:PRK09874 238 IAPILTLYVRELAGNVSNIAFISGMIAsvpgVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGIL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 102 RVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLL-ATLLSFMAVLLSLM 180
Cdd:PRK09874 318 RFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVtAGVVLFNAVYSWNS 397
|
....*...
gi 446362813 181 TKMPFTPQ 188
Cdd:PRK09874 398 LRRRRIPQ 405
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
45-305 |
4.52e-06 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 48.42 E-value: 4.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 45 GLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIHGVTWA-VST-TAVgtaITD 122
Cdd:cd17389 67 GLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGnVSLsTAI---VAD 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 123 IIPDSRRGEGMGWYGMAMTIAMAIGPMIG--LAVVQNYSFHGLFLLATLLSFMAVLLSLMTKMPFTPQKekgkiqlFEKS 200
Cdd:cd17389 144 VTSPKKRSKGMALIGVAFSLGFIIGPMIGayFASFTRSLGEVFFSMPALFALVLALADLLFIFFFLPET-------LPSN 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 201 VLSITIVVFFLSFAYGGITTFLPLFA------SSIDvnPGTFFLVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIA 274
Cdd:cd17389 217 LRRLGLVYFLYLFLFSGLEFTLTFLThqrfqyTSMQ--QGKMFFFIGIIMALVQGGYVRRIKPGKEKKAVLQGLILLIPA 294
|
250 260 270
....*....|....*....|....*....|.
gi 446362813 275 IVVLTISNNLIGVVIAATLYGVGFGSAQPAL 305
Cdd:cd17389 295 FLLIGWASSVTVLYAGLFLYSFAAATVVPCL 325
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
30-184 |
4.98e-06 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 48.21 E-value: 4.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 30 LPLFIK-EIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIHGVT 108
Cdd:pfam05977 241 LPLVARdLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLGGAA 320
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446362813 109 WAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFMAVLLSLMTKMP 184
Cdd:pfam05977 321 WITALTTLNVAVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALLGAAAALLAGAAAGLRFRLP 396
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
42-370 |
6.37e-06 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 48.21 E-value: 6.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 42 SQVGLMMGMFTIAA---VVIRPIIGGML-DQYGRRSFIIFGLIFFG-----LTMYSYNLASTIVLLAVLRVIHGVTWAVS 112
Cdd:pfam05977 41 SASPLMVALVQAAAtlpIFLLSIPAGALaDNFDRRKIMLAGQLLLAlvstlLTLLAGLGLLSPWLLLGLTFLGGIGTALM 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 113 TTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLlSFMAVLLSLM------TKMPFT 186
Cdd:pfam05977 121 DPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPAFTFALNAL-SYFAVIAALWrwkraaPASPLP 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 187 PQKEKGKIQL--------FEKSVLSITIVVFFLSFAygGITTFLPLFA-SSIDVNPGTF------FLVYAIALTIVRPis 251
Cdd:pfam05977 200 RERIFGAVRAglrftamsRELRSVLVRAFAFGLSAS--AVWALLPLVArDLLDGDAIFYgillgaVGVGAILGALSLP-- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 252 gKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFFTAFDL 331
Cdd:pfam05977 276 -RLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLGGAAWITALTTLNVAVQLSVPRWVRGRALAVYQTVFFG 354
|
330 340 350
....*....|....*....|....*....|....*....
gi 446362813 332 GIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVFF 370
Cdd:pfam05977 355 GMAAGSWLWGAVAEALSVTGALLGAAAALLAGAAAGLRF 393
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
250-377 |
9.50e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 47.23 E-value: 9.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 250 ISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFFTAF 329
Cdd:cd17475 50 PAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGV 129
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 446362813 330 DLGIGLGAILLGVVSQMFGYRILFSGSA-ISALTALIIFVFFVKQRLGK 377
Cdd:cd17475 130 PLGGALAAALLPPLALHYGWRAAFVVAGlVSILAAVLFWLFYREPPAAS 178
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
46-369 |
1.09e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.83 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 46 LMMGMFTIAAVVIRPI---IGGML-DQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAIT 121
Cdd:cd17316 36 LQTGLLFAAGFLGRPIgalLFGYLgDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 122 DIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVV----QNYSFHGLFLLATLLSFMAVLLSlmtkmpftpqkekgkiqlf 197
Cdd:cd17316 116 EFAPSKRRGFALGLLQSGWALGALLAALVASLLIpllsGDWGWRILFLIGALPALLALLLR------------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 198 eKSVLSITIVVFFLSFAYGGITTFLPLFASSIDVNPGT----FFLVYAIALTIVRPISGKLLDKYGE-----VFIILPAL 268
Cdd:cd17316 177 -RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPAtsslYLLLISLGALVGALIAGLLSDRIGRkktlvIGLILSGI 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 269 CITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLtivDPSKRGVANAsffTAFDLGIGLGAILLGVVSQMFG 348
Cdd:cd17316 256 LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELF---PTEVRATGVG---LSYNLGRLGGGGAPPLIALLLA 329
|
330 340
....*....|....*....|.
gi 446362813 349 YRILFSGSAISALTALIIFVF 369
Cdd:cd17316 330 STGGTGVPALILALLAIVALI 350
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
27-358 |
2.18e-05 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 46.03 E-value: 2.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 27 VPTLPLFIKEiggnESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIHG 106
Cdd:cd17384 20 VPIIPDYLNE----NVRVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 107 VTWAVSTTAVGTAITDIIPDS-RRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFMAVLLSLMT-KMP 184
Cdd:cd17384 96 VGSACSSVAGMGMLASLYPDDkERGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFIlQPS 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 185 FTPQKEKGKIQLFE----KSVLSITIVVFFLSFAYGGITTFLPLFASSIDVNP----GTFFLVYAIALTIVRPISGKLLD 256
Cdd:cd17384 176 VKSEESEEGTPWKTllkdPYILIAAGAICFSNSGIAILEPCLPIWMMETMCPPkwqlGTAFLPDSIGYLIGTNLFGPLAH 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 257 KYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVD---PSKRGVANASFFTAFDLGI 333
Cdd:cd17384 256 KIGRWLCSLLGMLLVGISLILIPLAKNIYGLIIPHFGLGLGIGMVDSSMMPLLAYLVDlrhSSVYGSVYAIADVAFCLAF 335
|
330 340
....*....|....*....|....*
gi 446362813 334 GLGAILLGVVSQMFGYRILFSGSAI 358
Cdd:cd17384 336 ALGPSLGGAIVKSIGFPWLMRIIGI 360
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
209-373 |
2.57e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 45.72 E-value: 2.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 209 FFLSFAYGGITTFLPLFASSIDVNPGTF--------FLVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTI 280
Cdd:cd17391 6 FFTGIGFSLIAPFLPLYIEQLGVTSGGLvelwsglaFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 281 SNNLIGVVIAATLYGV--GFGSAQPALQAamlTIVDPSKRGVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAI 358
Cdd:cd17391 86 VTNVWQLLILRLLQGVfsGYVPNATALIA---SQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGG 162
|
170
....*....|....*
gi 446362813 359 SALTALIIFVFFVKQ 373
Cdd:cd17391 163 LLFLAFLLTLFFVKE 177
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
9-371 |
3.28e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 45.34 E-value: 3.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 9 FIQMTFAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYS 88
Cdd:cd17312 5 FLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 89 YNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLAT 168
Cdd:cd17312 85 MGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 169 LLSFMAVLLSLMTkmpftpqkekgkIQLFEKSVLSITIVVFFLSFAYGGITTFLPLFASSID----VNPGTFFLVYAIAL 244
Cdd:cd17312 165 IVGLVVAIILFFF------------LRDSPPYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKgyslIDAGWFSSLYEVGG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 245 TIVRPISGKLLDKYGE----VFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVdPSKRGV 320
Cdd:cd17312 233 IAGTILAGLLSDKLFGgrraPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDI-GRKEAA 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446362813 321 ANASFFTAF--DLGIGLGAILLGVVSQMFGyrilFSGSAISALTALIIFVFFV 371
Cdd:cd17312 312 GTATGFVGLfgYLGASLAGLPLGYIIDHYG----WSTVFYFLISAALLSVLLL 360
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
9-365 |
5.30e-05 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 44.90 E-value: 5.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 9 FIQMTFAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGL-------IF 81
Cdd:cd17385 1 LISLALANFSSMICYSILAPFFPREAEKKGVSDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMfvsggctIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 82 FGLTMYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRrGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFH 161
Cdd:cd17385 81 FGFLDRVPDGTVFIALCFLVRIVEAVGFAAFITASFAIIAKEFPNNI-ATVLGTLETFSGLGLMLGPPLGGFLYQAGGYE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 162 GLFLLATLLSFMAVLLS--LMTKMPFTPQKEKGKIQLFEK--SVLSITIVVFFLSFAYGGITTFLPLFASSIDVNP---G 234
Cdd:cd17385 160 LPFLVLGCLLLLTVPLNmfILPRYDDDPSPKSGSMLKLLKipSVLLLCLSIVSGSVSLGFLDPTLSPHLRQFKLSPgqvG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 235 TFFLVYAIALTIVRPISGKLLDKY--GEVFIILPALCITIIAIVV-----LTISNNLIGVVIAATLYGVGFG-SAQPALQ 306
Cdd:cd17385 240 LMFLILAGSYAISAPLWGWLSDKKkiPKWLMVIGSIITGVGFLLLgpaplLPIKSELWMVIIGLVLLGLSLGaALVPTFP 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446362813 307 AAMLTIV------DPSKRGVANASFFTAFDLGIGLGAILLGVVSQMFGYRIlfsGSAISALTALI 365
Cdd:cd17385 320 ELLNCAReygfpdNLSTYGLVSGLFNAAFSLGAFIGPTLGGFLLERLGFEW---AATIQAGLAFV 381
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
204-374 |
6.62e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 44.72 E-value: 6.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 204 ITIVVFFLSFAYGGITTFLPLFASSIDVNP---GTFFLVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTI 280
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSAsqlGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 281 SNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFFTAFDLGIGLGAILLGVVSQ--MFGYRILFSGSAI 358
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160
|
170
....*....|....*.
gi 446362813 359 SALTALIIFVFFVKQR 374
Cdd:cd06174 161 LALLAAILLLLVVPDP 176
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
7-180 |
1.06e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 43.70 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 7 KSFIQMTFAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQ--YGRRSFIIFGLIFFGL 84
Cdd:cd17352 183 PTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGL 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 85 TMYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMI-GLAVVQNYSFHGL 163
Cdd:cd17352 263 SLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIaGLLRDYTGDYDAA 342
|
170
....*....|....*..
gi 446362813 164 FLLATLLSFMAVLLSLM 180
Cdd:cd17352 343 FYFCGACLLLSGVLLFL 359
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
3-179 |
1.12e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 43.71 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 3 RLWTKSFIQMTFAMLFLFTGFYLLVPTLPLFIKEIGG-NESQVGLMMGMFTIAAVVIRPIIGGMLD---QYGRRSFIIFG 78
Cdd:cd17319 175 WFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGfSLKQVGLLAAIPFLAGAIGMILGGRLSDrllRGARRLVIIIG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 79 LIFFGLTMYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPM-IGLAVVQN 157
Cdd:cd17319 255 LLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLlIGYLVDAT 334
|
170 180
....*....|....*....|..
gi 446362813 158 YSFHGLFLLATLLSFMAVLLSL 179
Cdd:cd17319 335 GSYTAAFLFLAAVALLAALLVL 356
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
4-179 |
1.69e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.36 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 4 LWTKSFIQMTFAMLFLFTGFYLLVPTLPLFIKEIGG-NESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFF 82
Cdd:cd17316 174 LLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGlSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILS 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 83 GLTMY--SYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGW-YGMAMTIAMAIGPMIGLAVVQNYS 159
Cdd:cd17316 254 GILALplFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLsYNLGRLGGGGAPPLIALLLASTGG 333
|
170 180
....*....|....*....|
gi 446362813 160 FHGLFLLATLLSFMAVLLSL 179
Cdd:cd17316 334 TGVPALILALLAIVALIVAL 353
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
234-374 |
3.12e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.54 E-value: 3.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 234 GTFFLVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPAlQAAMLTIV 313
Cdd:cd17478 34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPE-GARLASQA 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446362813 314 DPSKRGVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVFFVKQR 374
Cdd:cd17478 113 AGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK 173
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
70-374 |
3.99e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 41.91 E-value: 3.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 70 GRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAI-GP 148
Cdd:cd06180 62 RARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALsGL 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 149 MIGLAVVQNYSFHGLFLLATLLSFMAVLLSLMT----KMPFTPQKEKGKIQLFEKSVLSITIVVFFLSFAYGGITTFLPL 224
Cdd:cd06180 142 LVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLlrrgPSAPTEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPL 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 225 FASSI---DVNPGTFFLVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFgSA 301
Cdd:cd06180 222 IARETgagSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTF-MA 300
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446362813 302 QPALQAAMLTIVDPSKRGVANASFFTAFDLGIGLGAILLGVVSQMFGYriLFSGSAISALTALIIFVFFVKQR 374
Cdd:cd06180 301 ITALVMALARELAPPAAPRALALMTASFGVGQILGPLLAGWLADATGG--FAPALILAAAALVVAALLALLVL 371
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
240-353 |
6.28e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 41.40 E-value: 6.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 240 YAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRG 319
Cdd:cd17502 39 YLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERG 118
|
90 100 110
....*....|....*....|....*....|....
gi 446362813 320 VANASFFTAFDLGIGLGAILLGVVSQMFGYRILF 353
Cdd:cd17502 119 KYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCF 152
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
7-179 |
6.52e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.26 E-value: 6.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 7 KSFIQMTFAMLFLFTGFYLLVPTLPLFIKEIGGN-ESQVGLMMGMFTIAAVVIRPIIGGMLD-QYGRRSFIIFGLIFFGL 84
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLsVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 85 TMYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMI-GLAVVQNYSFHGL 163
Cdd:cd06174 283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLaGFLLAATFGLTGA 362
|
170
....*....|....*.
gi 446362813 164 FLLATLLSFMAVLLSL 179
Cdd:cd06174 363 FLVLAVLLLLAAILLL 378
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
25-305 |
7.52e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.15 E-value: 7.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 25 LLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVI 104
Cdd:cd17333 14 LLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 105 HGVTWAVSTTAVGTAITDIIPdSRRGEGMGWYGMAMTIAMAIGPMI-GLAVVQNYSFHGLFLLATLLSFMAVLLSLMTKM 183
Cdd:cd17333 94 AGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIaTSLLTSELSWSWAYLIIGLIYLLLAILILLTLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 184 PFTPQK-----EKGKIQLFEKSVLSITIVVFF--LSFAYGGITTFLPLFASSI--------DVNPGTFFLVYAIALTIVR 248
Cdd:cd17333 173 PELPSArnpqqSVGAFSASASRLLRNPSIILGalALFLYVGAETAFSSWVPSYlvekkhvsDGLAGYLLSGFWVGITIGR 252
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 446362813 249 PISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPAL 305
Cdd:cd17333 253 LLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTI 309
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
15-182 |
8.36e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 41.02 E-value: 8.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 15 AMLFLFTGFYLLVPTLPLFIKE-----IGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIF--FGLTMY 87
Cdd:cd17504 185 TALLAGFGMFMVFQLLPQLLQLptptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVIsaVGLLLL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 88 SYNLaSTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYS-------- 159
Cdd:cd17504 265 ALLH-SSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTvsitsggv 343
|
170 180
....*....|....*....|....*...
gi 446362813 160 -----FHGLFLLATLLSFMAVLLSLMTK 182
Cdd:cd17504 344 ptegaYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
14-177 |
9.27e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.07 E-value: 9.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 14 FAMLFLFTGFYLLVPTLPLFIKEIG---GNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYN 90
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVadlGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 91 LASTIVLLAVLRVIHGVTWAVStTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNY--SFHGLFLLAT 168
Cdd:cd06179 81 TAKSVNMLIGGQALIGIGAGTQ-GLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIFYINA 159
|
....*....
gi 446362813 169 LLSFMAVLL 177
Cdd:cd06179 160 IFNALALIL 168
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
250-369 |
1.03e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 40.80 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 250 ISGKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFFTAF 329
Cdd:TIGR00895 71 FFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGY 150
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 446362813 330 DLGIGLGAILLGVVSQMFGYRILFS-GSAISALTALIIFVF 369
Cdd:TIGR00895 151 PIGAAVGGFLAGWLIPVFGWRSLFYvGGIAPLLLLLLLMRF 191
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
44-371 |
1.14e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 40.67 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 44 VGLMMGMFTIAAVVIRPIIGGMLDQY-----GRRSFIIFGLIFFGLTMYS--YNLASTIVLLAVLRVIHGVTWAVSTTAV 116
Cdd:cd17332 37 AGTIFLVARIIDAINDPLMGYLIDRTrsrwgRFRPWLLWGAIPLALLFVLlfTTPDGSGTGKLIYALITYILLDLLYTLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 117 GTAITDIIP---------DSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFMAVLLSLMT-----K 182
Cdd:cd17332 117 NIPYTALIPeltddpeerTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICffgtrE 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 183 MPFTPQKEKGKIQLFE--------KSVLSITIVVFFLSFAYGGITTFLPLFASSIDVNPGTFFLV---YAIALTIVRPIS 251
Cdd:cd17332 197 RVVPPEEEKSKLPLLKslkallknRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLlllILSGALLALLPW 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 252 GKLLDKYGE--VFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPS--KRGVANASFFT 327
Cdd:cd17332 277 PPLKKRFGKkkAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGelKTGKRREGIFY 356
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 446362813 328 AFD-----LGIGLGAILLGVVSQMFGYRILFSGSAISALTALIIFVFFV 371
Cdd:cd17332 357 SVMtffrkLGLALAGALVGLILSLAGYVANAAAQSASALNGIRLLIAVL 405
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
7-177 |
1.31e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.59 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 7 KSFIQMTFAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIA-AVVIRPIIGGMLDQYGRRSFIIFGLIFFGLT 85
Cdd:cd17369 228 RALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVvAAITIPLFGWLSDRVGRRPVYLAGALLAALF 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 86 MYSYNLA----STIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGW-YGMAMTIAMAIGPMIGLA-VVQNYS 159
Cdd:cd17369 308 AFPFFWLldtgSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLgYQLGAILGGGFAPLIATAlVAATGS 387
|
170 180
....*....|....*....|.
gi 446362813 160 FHGL---FLLATLLSFMAVLL 177
Cdd:cd17369 388 WWPValyLAALAVISLVAALF 408
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
14-179 |
1.75e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 40.30 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 14 FAMLFLFTGF--YLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNL 91
Cdd:cd17313 251 FPFELFFTDYmgEEVYHGTSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMAL 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 92 ASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGM--GWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATL 169
Cdd:cd17313 331 VHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRGQGTdtGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAV 410
|
170
....*....|
gi 446362813 170 LSFMAVLLSL 179
Cdd:cd17313 411 ASFLSLVGAL 420
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
4-180 |
1.76e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.24 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 4 LWTKSFIQMTFAMLFLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFG 83
Cdd:COG2807 212 WRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLG 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 84 LTMYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRR-GEGMGWYGMAMTIAMAIGP-MIGLAVVQNYSFH 161
Cdd:COG2807 292 LAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPlLVGALHDATGSWT 371
|
170
....*....|....*....
gi 446362813 162 GLFLLATLLSFMAVLLSLM 180
Cdd:COG2807 372 AALLLLAALAVLMLVAGLL 390
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
46-187 |
2.86e-03 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 39.40 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 46 LMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIP 125
Cdd:cd17435 40 MVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAP 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446362813 126 DSRRGEGMGWYGMAMTIAMAigpmigLAVVQNYSFHGLFLLATLLSFMAVLLSLMTK--MPFTP 187
Cdd:cd17435 120 QHRRGLLVSLNELMIVIGIL------LAYISNYAFANVSNGWKYMFGLVIPLAALQAiaMYFLP 177
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
202-370 |
4.21e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 4.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 202 LSITIVVFFLSFAYGGITTFLPLFASSIDVNPGTFFLVYAIALTIVRPISGKLLDKYGEVFIILPALCITIIAIVVL-TI 280
Cdd:cd17353 220 LMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLpFI 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 281 SNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSKRGVANASFFTAFDLGIGLGAILLGVVSQMFGYRILFSGSAISA 360
Cdd:cd17353 300 GSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALS 379
|
170
....*....|
gi 446362813 361 LTALIIFVFF 370
Cdd:cd17353 380 LVALALALLL 389
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
10-173 |
4.35e-03 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 38.93 E-value: 4.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 10 IQMTFAMLFLFTGFYL----LVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLT 85
Cdd:cd17488 2 IHILASMFIGYAVFYLtrksFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 86 MYSYNLASTIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFL 165
Cdd:cd17488 82 NILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMY 161
|
....*...
gi 446362813 166 LATLLSFM 173
Cdd:cd17488 162 VPGIIAIL 169
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
3-162 |
5.08e-03 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 38.87 E-value: 5.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 3 RLWTKSFIQMTFAMLFLFTGFYLLVPTL----PLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFG 78
Cdd:PRK09556 21 KMWFKPFMQSYLVVFIGYLTMYLIRKNFkaaqNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 79 LIFFGLTMYSYNLA-----STIVLLAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLa 153
Cdd:PRK09556 101 LILSAICMLGFGASlgsgsVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVAL- 179
|
....*....
gi 446362813 154 VVQNYSFHG 162
Cdd:PRK09556 180 WGANYFFDG 188
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
18-151 |
5.83e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 38.49 E-value: 5.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 18 FLFTGFYLLVPTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVL 97
Cdd:TIGR00895 261 MLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTL 340
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 446362813 98 LAVLRVIHGVTWAVSTTAVGTAITDIIPDSRRGEGMGW-YGMAMTIAMaIGPMIG 151
Cdd:TIGR00895 341 LLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWaIGIGRLGAI-IGPILA 394
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
14-177 |
5.93e-03 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 38.34 E-value: 5.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 14 FAMLFLFTGFYLLVPtlPLFIKEIGGNESQVGLMMG-MFTIAAVVIRPIIGGM----LDQYGRRSFIIFGLIFFG---LT 85
Cdd:cd17326 204 FVVLFIFANLETIGT--PLTMDMYGWTREEAVLYNGiILAVSGVLSVLVFLLFkflsLGLIDERKILLGGLILFFlgfVV 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 86 MYSYNLASTIVLlavlrvihGVTWAVSTTAVGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFL 165
Cdd:cd17326 282 TLPWGITGVILF--------GLGYPIGNVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWI 353
|
170
....*....|..
gi 446362813 166 LATLLSFMAVLL 177
Cdd:cd17326 354 ITLGLLLLAIIL 365
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
28-186 |
5.97e-03 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 38.38 E-value: 5.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 28 PTLPLFIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIHGV 107
Cdd:PRK15402 34 PGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 108 TWAVsTTAVG-TAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFMAvLLSLMTKMPFT 186
Cdd:PRK15402 114 GLCF-IGAVGyAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALS-FFGLWRAMPET 191
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
252-373 |
7.72e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 37.97 E-value: 7.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 252 GKLLDKYGEVFIILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAqpALQAAMLTIVDPSKRGVANA----SFFT 327
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISS--VVMALLADLTREENRTKAMAligaSIGI 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 446362813 328 AFDLGIGLGAILlgvvSQMFGYRILFSGSAISALTALIIFVFFVKQ 373
Cdd:cd17472 131 AFAISMVLGPLL----AAHLGVSGLFLITAILSLVSLLILLFFVPD 172
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
41-369 |
8.76e-03 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 37.95 E-value: 8.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 41 ESQVGLMMgmfTI-AAVVIRPIIGGML--DQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVI----HGVTWAVST 113
Cdd:PRK03545 43 TAQVGLML---TIyAWVVALMSLPLMLltSNVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRIGiafaHAIFWSITA 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 114 T-AVGTAitdiiPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYSFHGLFLLATLLSFmAVLLSLMTKMPFTPQKEKG 192
Cdd:PRK03545 120 SlAIRVA-----PAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLAIGGGAL-ITLLLLIKLLPLLPSEHSG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 193 KIQ----LFEKSVLS----ITIVVFFLSF-AYGGITTFLpLFASSIDVNPGTFFL-VYAIALTIVRPISGKLLDKYGEVF 262
Cdd:PRK03545 194 SLKslplLFRRPALVslylLTVVVVTAHFtAYSYIEPFV-QQVAGLSENFATLLLlLFGGAGIIGSVLFSRLGNRHPSGF 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 263 IILPALCITIIAIVVLTISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIvDPSKRGVANASFFTAFDLGIGLGAILLGV 342
Cdd:PRK03545 273 LLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIGLAMQVKVLKL-APDATDVAMALFSGIFNIGIGAGALLGNQ 351
|
330 340
....*....|....*....|....*...
gi 446362813 343 VSQMFGYR-ILFSGSAIsALTALIIFVF 369
Cdd:PRK03545 352 VSLHLGLSsIGYVGAAL-ALAALVWSIL 378
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
36-181 |
8.89e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 37.94 E-value: 8.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 36 EIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGLTMYSYNLASTIVLLAVLRVIHGVTWAVSTTA 115
Cdd:cd17315 28 GFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVL 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446362813 116 VGTAITDIIPDSRRGEGMGWYGMAMTIAMAIGPMIGLAVVQNYS--FHGLFLLATLLSFMAVLLSLMT 181
Cdd:cd17315 108 VPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPgwWRLMFALAAVPALLQLLLMFFL 175
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
33-317 |
9.88e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 37.53 E-value: 9.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 33 FIKEIGGNESQVGLMMGMFTIAAVVIRPIIGGMLDQYGRRSFIIFGLIFFGL-TMYSYNLASTIVLLAVLRVIHGVTWAV 111
Cdd:cd17352 29 LLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALgLLLSSFATSLWQLYLTYGVLGGLGLGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 112 STTAVGTAITDIIpDSRRgegmgwyGMAMTIAMA---IGPMIGLAVVQ----NYSFHGLFLLATLLSFMAVLLSLMTKMp 184
Cdd:cd17352 109 IYSPAIVIVGQYF-EKKR-------GLATGIAVAgsgVGTFVFPPLLRylldNYGWRGALLILGGLCLNLCVCGLLLRL- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446362813 185 ftpqkekgkiqLFEKSVLSITIVVFFLSFAYGGITTFLPLFASSIDVNPG-TFFLVYAIAL--TIVRPISGKLLDKYGEV 261
Cdd:cd17352 180 -----------LKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESdAAFLLSIIGIsdIVGRILLGLLADKPRIG 248
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 446362813 262 FIILPALCITIIAIVVL--TISNNLIGVVIAATLYGVGFGSAQPALQAAMLTIVDPSK 317
Cdd:cd17352 249 RLYLYIFTLLILGLSLLafPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEK 306
|
|
| |
