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Conserved domains on  [gi|446367551|ref|WP_000445406|]
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MULTISPECIES: DNA-binding transcriptional regulator SfsB [Escherichia]

Protein Classification

helix-turn-helix domain-containing protein; LacI family DNA-binding transcriptional regulator( domain architecture ID 10013493)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family; HTH domain binds DNA and may function as a transcriptional regulator| LacI family DNA-binding transcriptional regulator functions as an activator or repressor by binding a specific effector ligand that either decreases (induction) or increases DNA-binding affinity (co-repression)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10344 PRK10344
DNA-binding transcriptional regulator SfsB;
1-92 9.37e-61

DNA-binding transcriptional regulator SfsB;


:

Pssm-ID: 182394  Cd Length: 92  Bit Score: 179.77  E-value: 9.37e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446367551  1 MESNFIDWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWIIWPSRYHDPLTHEFIDR 80
Cdd:PRK10344  1 MESNFIDWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWVIWPSRYHDPQTHEFIDR 80

                        90
                ....*....|..
gi 446367551 81 TQLIRSYTKPKK 92
Cdd:PRK10344 81 TQLMRSYTKPKK 92
 
Name Accession Description Interval E-value
PRK10344 PRK10344
DNA-binding transcriptional regulator SfsB;
1-92 9.37e-61

DNA-binding transcriptional regulator SfsB;


Pssm-ID: 182394  Cd Length: 92  Bit Score: 179.77  E-value: 9.37e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446367551  1 MESNFIDWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWIIWPSRYHDPLTHEFIDR 80
Cdd:PRK10344  1 MESNFIDWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWVIWPSRYHDPQTHEFIDR 80

                        90
                ....*....|..
gi 446367551 81 TQLIRSYTKPKK 92
Cdd:PRK10344 81 TQLMRSYTKPKK 92
HTH_35 pfam13693
Winged helix-turn-helix DNA-binding;
7-72 7.32e-39

Winged helix-turn-helix DNA-binding;


Pssm-ID: 433408  Cd Length: 70  Bit Score: 123.50  E-value: 7.32e-39
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446367551   7 DWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWIIWPSRYHDP 72
Cdd:pfam13693  1 DWHPADIKAALRKRGTTLAALSRSAGLSSSTLSNALTRPWPKGERIIAEALGVPPEEIWPSRYFDD 66
SfsB COG3423
Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];
7-70 8.79e-35

Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];


Pssm-ID: 442649 [Multi-domain]  Cd Length: 69  Bit Score: 113.39  E-value: 8.79e-35
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446367551  7 DWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWIIWPSRYH 70
Cdd:COG3423   6 DWHPADIKAALRKRGTSLAALAREAGLSSSTLSNALTRPWPKGERAIAEALGVPPEEIWPSRYA 69
 
Name Accession Description Interval E-value
PRK10344 PRK10344
DNA-binding transcriptional regulator SfsB;
1-92 9.37e-61

DNA-binding transcriptional regulator SfsB;


Pssm-ID: 182394  Cd Length: 92  Bit Score: 179.77  E-value: 9.37e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446367551  1 MESNFIDWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWIIWPSRYHDPLTHEFIDR 80
Cdd:PRK10344  1 MESNFIDWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWVIWPSRYHDPQTHEFIDR 80

                        90
                ....*....|..
gi 446367551 81 TQLIRSYTKPKK 92
Cdd:PRK10344 81 TQLMRSYTKPKK 92
HTH_35 pfam13693
Winged helix-turn-helix DNA-binding;
7-72 7.32e-39

Winged helix-turn-helix DNA-binding;


Pssm-ID: 433408  Cd Length: 70  Bit Score: 123.50  E-value: 7.32e-39
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446367551   7 DWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWIIWPSRYHDP 72
Cdd:pfam13693  1 DWHPADIKAALRKRGTTLAALSRSAGLSSSTLSNALTRPWPKGERIIAEALGVPPEEIWPSRYFDD 66
SfsB COG3423
Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];
7-70 8.79e-35

Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];


Pssm-ID: 442649 [Multi-domain]  Cd Length: 69  Bit Score: 113.39  E-value: 8.79e-35
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446367551  7 DWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWIIWPSRYH 70
Cdd:COG3423   6 DWHPADIKAALRKRGTSLAALAREAGLSSSTLSNALTRPWPKGERAIAEALGVPPEEIWPSRYA 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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