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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Bacillus]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
9-145 6.38e-44

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 141.45  E-value: 6.38e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446368251   9 LDDLDVQILDILQKESQVSNAELARRVNLSPAAMHARIKRLDGEGFIDKQVAILNQEKLGFDLLCFIFMSTNIHQSDKle 88
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE-- 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446368251  89 vLEKELEAMPEVLECHCLTGEYDYLLKVANRDRKELEQFI-RKLNKL-GITRIQTSLAL 145
Cdd:COG1522   81 -FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLlERLAALpGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
9-145 6.38e-44

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 141.45  E-value: 6.38e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446368251   9 LDDLDVQILDILQKESQVSNAELARRVNLSPAAMHARIKRLDGEGFIDKQVAILNQEKLGFDLLCFIFMSTNIHQSDKle 88
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE-- 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446368251  89 vLEKELEAMPEVLECHCLTGEYDYLLKVANRDRKELEQFI-RKLNKL-GITRIQTSLAL 145
Cdd:COG1522   81 -FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLlERLAALpGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 9-117 1.39e-34

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 116.85  E-value: 1.39e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446368251     9 LDDLDVQILDILQKESQVSNAELARRVNLSPAAMHARIKRLDGEGFIDKQVAILNQEKLGFDLLCFIFMstNIHQSDKLE 88
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGV--TLENPDKLE 78

                           90       100
                   ....*....|....*....|....*....
gi 446368251    89 VLEKELEAMPEVLECHCLTGEYDYLLKVA 117
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVR 107
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-158 1.30e-24

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 93.29  E-value: 1.30e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446368251   1 MESSVIKVLDDLDVQILDILQKESQVSNAELARRVNLSPAAMHARIKRLDGEGFIDKQVAILNQEKLGFDLLCFIFMSTN 80
Cdd:PRK11169   4 SKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446368251  81 IHQSDKLEVLEKELEAMPEVLECHCLTGEYDYLLKVANRD----RKELEQFIRKLNKLGITRiqTSLALREIKYSTVLPI 156
Cdd:PRK11169  84 RGAPDVFEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDmsayRKLLGETLLRLPGVNDTR--TYVVMEEVKQTNRLVI 161


                 ..
gi 446368251 157 RN 158
Cdd:PRK11169 162 KT 163
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 81-147 2.76e-17

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 71.79  E-value: 2.76e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446368251   81 IHQSDKLEVLEKELEAMPEVLECHCLTGEYDYLLKVANRDRKELEQFI-RKLNKL-GITRIQTSLALRE 147
Cdd:pfam01037   5 LEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLrEKLRSLpGVARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-58 5.08e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.89  E-value: 5.08e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 446368251  10 DDLDVQILDILQkESQVSNAELARRVNLSPAAMHARIKRLDGEGFIDKQ 58
Cdd:cd00090    6 DPTRLRILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
9-145 6.38e-44

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 141.45  E-value: 6.38e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446368251   9 LDDLDVQILDILQKESQVSNAELARRVNLSPAAMHARIKRLDGEGFIDKQVAILNQEKLGFDLLCFIFMSTNIHQSDKle 88
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE-- 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446368251  89 vLEKELEAMPEVLECHCLTGEYDYLLKVANRDRKELEQFI-RKLNKL-GITRIQTSLAL 145
Cdd:COG1522   81 -FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLlERLAALpGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 9-117 1.39e-34

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 116.85  E-value: 1.39e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446368251     9 LDDLDVQILDILQKESQVSNAELARRVNLSPAAMHARIKRLDGEGFIDKQVAILNQEKLGFDLLCFIFMstNIHQSDKLE 88
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGV--TLENPDKLE 78

                           90       100
                   ....*....|....*....|....*....
gi 446368251    89 VLEKELEAMPEVLECHCLTGEYDYLLKVA 117
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVR 107
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-158 1.30e-24

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 93.29  E-value: 1.30e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446368251   1 MESSVIKVLDDLDVQILDILQKESQVSNAELARRVNLSPAAMHARIKRLDGEGFIDKQVAILNQEKLGFDLLCFIFMSTN 80
Cdd:PRK11169   4 SKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446368251  81 IHQSDKLEVLEKELEAMPEVLECHCLTGEYDYLLKVANRD----RKELEQFIRKLNKLGITRiqTSLALREIKYSTVLPI 156
Cdd:PRK11169  84 RGAPDVFEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDmsayRKLLGETLLRLPGVNDTR--TYVVMEEVKQTNRLVI 161


                 ..
gi 446368251 157 RN 158
Cdd:PRK11169 162 KT 163
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 9-141 1.54e-21

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 85.15  E-value: 1.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446368251   9 LDDLDVQILDILQKESQVSNAELARRVNLSPAAMHARIKRLDGEGFIDKQVAILNQEKLGFDLLCFIFMSTNiHQSDKLE 88
Cdd:PRK11179   7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILK-SAKDYPS 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446368251  89 VLEKeLEAMPEVLECHCLTGEYDYLLKVANRDRKELEQFIrklnklgITRIQT 141
Cdd:PRK11179  86 ALAK-LESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVL-------INKIQT 130
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 81-147 2.76e-17

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 71.79  E-value: 2.76e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446368251   81 IHQSDKLEVLEKELEAMPEVLECHCLTGEYDYLLKVANRDRKELEQFI-RKLNKL-GITRIQTSLALRE 147
Cdd:pfam01037   5 LEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLrEKLRSLpGVARTETSIVLST 73
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
10-49 1.12e-11

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 56.22  E-value: 1.12e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 446368251   10 DDLDVQILDILQKESQVSNAELARRVNLSPAAMHARIKRL 49
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRL 40
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
11-55 2.26e-09

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 50.51  E-value: 2.26e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 446368251   11 DLDVQILDILQKESQVSNAELARRVNLSPAAMHARIKRLDGEGFI 55
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-58 5.08e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.89  E-value: 5.08e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 446368251  10 DDLDVQILDILQkESQVSNAELARRVNLSPAAMHARIKRLDGEGFIDKQ 58
Cdd:cd00090    6 DPTRLRILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
15-60 1.26e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 37.60  E-value: 1.26e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 446368251  15 QILDILQKESQVSNAELARRVNLSPAAMHARIKRLDGEGFIDKQVA 60
Cdd:COG2345   17 RILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETE 62
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 16-58 2.59e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 34.45  E-value: 2.59e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 446368251   16 ILDILQKESQVSNAELARRVNLSPAAMHARIKRLDGEGFIDKQ 58
Cdd:pfam01047   8 ILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERS 50
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 9-58 2.71e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 34.49  E-value: 2.71e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 446368251    9 LDDLDVQILDILQKESQVSNAELARRVNLSPAAMHARIKRLDGEGFIDKQ 58
Cdd:pfam12802   3 LTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVERE 52
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
16-58 3.35e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 35.26  E-value: 3.35e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 446368251    16 ILDILQKESQVSNAELARRVNLSPAAMHARIKRLDGEGFIDKQ 58
Cdd:smart00347  15 VLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRRE 57
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
2-58 3.97e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 36.01  E-value: 3.97e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446368251   2 ESSVIKVL-DDLDVQILDILQKESQVSNAELARRVNLSPAAMHARIKRLDGEGFIDKQ 58
Cdd:COG3398   87 EKKILAYLrRETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERE 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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