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Conserved domains on  [gi|446369000|ref|WP_000446855|]
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MULTISPECIES: AraC family transcriptional regulator [Bacillus]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12204073)

AraC family transcriptional regulator containing an AraC family helix-turn-helix (HTH) DNA-binding domain, may regulate the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0006355|GO:0003700
PubMed:  33837749|12596232|10473770|15808743|9409145|11282467

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YdeE COG3708
Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription] ...
 133-298 1.81e-55

Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription];


:

Pssm-ID: 442922  Cd Length: 157  Bit Score: 176.75  E-value: 1.81e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000 133 MEYRIVNKPEFLVAGYELKTTSKEGKNHQDIPAFWQEYLQKDLGTtIPNRKDTSqwVELGLCTDFNLETGDFTYIIGMEV 212
Cdd:COG3708    1 MEYRIVEKPAFKLVGLSARTSNSDEEANEEIPALWQRFLPEGLAE-IPNLSNPG--GLYGVCTDYESDEGEFDYLAGVEV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000 213 TDFENVPNEIAKRTFPAATYAVFTTPKvpheEMVSSIHQTWNAVFSEWFPHSGYEHCGVTEFELYDERCheDKSEFAQVE 292
Cdd:COG3708   78 SSFDEVPEGLETLEIPAGTYAVFTHKG----PMPEALQETWQYIYSEWLPSSGYERADGPDFEVYDERD--DPSPDSEVE 151


                 ....*.
gi 446369000 293 LWIPVK 298
Cdd:COG3708  152 IWIPIK 157
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
24-105 2.10e-31

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 112.26  E-value: 2.10e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000    24 TLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHGFQSHETFTRAFKKLFQMTPSE 103
Cdd:smart00342   3 TLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSE 82


                   ..
gi 446369000   104 YR 105
Cdd:smart00342  83 YR 84
 
Name Accession Description Interval E-value
YdeE COG3708
Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription] ...
 133-298 1.81e-55

Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription];


Pssm-ID: 442922  Cd Length: 157  Bit Score: 176.75  E-value: 1.81e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000 133 MEYRIVNKPEFLVAGYELKTTSKEGKNHQDIPAFWQEYLQKDLGTtIPNRKDTSqwVELGLCTDFNLETGDFTYIIGMEV 212
Cdd:COG3708    1 MEYRIVEKPAFKLVGLSARTSNSDEEANEEIPALWQRFLPEGLAE-IPNLSNPG--GLYGVCTDYESDEGEFDYLAGVEV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000 213 TDFENVPNEIAKRTFPAATYAVFTTPKvpheEMVSSIHQTWNAVFSEWFPHSGYEHCGVTEFELYDERCheDKSEFAQVE 292
Cdd:COG3708   78 SSFDEVPEGLETLEIPAGTYAVFTHKG----PMPEALQETWQYIYSEWLPSSGYERADGPDFEVYDERD--DPSPDSEVE 151


                 ....*.
gi 446369000 293 LWIPVK 298
Cdd:COG3708  152 IWIPIK 157
AraC_E_bind smart00871
Bacterial transcription activator, effector binding domain; This domain is found in the ...
 134-298 1.30e-36

Bacterial transcription activator, effector binding domain; This domain is found in the probable effector binding domain of a number of different bacterial transcription activators.and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.


Pssm-ID: 214874 [Multi-domain]  Cd Length: 158  Bit Score: 128.36  E-value: 1.30e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   134 EYRIVNKPEFLVAGYELKTTSKEgknhQDIPAFWQEYLQKDLGTTIPNRKDTSQWVELGLCTDFNLETGDFTYIIGMEVT 213
Cdd:smart00871   1 EVRIVELPAFKVAGLRHRGPNED----EKIPELWQRLIQWAKELGLLPVGNSGEPYGVYYDDPDDTPDGEFRYDAGVEVS 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   214 DFENVPNEIAKRTFPAATYAVFTTPKVPHEEmvssIHQTWNAVFSEWFPHSGYEH-CGVTEFELYDERCHEDKSEFAQVE 292
Cdd:smart00871  77 DEVEAPEGVETKTIPAGKYAVFTHKGGSYDE----IQEAWEAIYGEWLPNSGYELrDAGPDFEVYLNDPPDTDPEELVTE 152


                   ....*.
gi 446369000   293 LWIPVK 298
Cdd:smart00871 153 IYIPVK 158
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
24-105 2.10e-31

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 112.26  E-value: 2.10e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000    24 TLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHGFQSHETFTRAFKKLFQMTPSE 103
Cdd:smart00342   3 TLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSE 82


                   ..
gi 446369000   104 YR 105
Cdd:smart00342  83 YR 84
Cass2 pfam14526
Integron-associated effector binding protein; This family contains Cass2 from Vibrio cholerae, ...
 136-297 2.60e-31

Integron-associated effector binding protein; This family contains Cass2 from Vibrio cholerae, an integron-associated protein that has been shown to bind cationic drug compounds with submicromolar affinity. Cass2 has been proposed to be representative of a larger family of independent effector-binding proteins associated with lateral gene transfer within Vibrio and other closely-related species.


Pssm-ID: 434016 [Multi-domain]  Cd Length: 149  Bit Score: 114.38  E-value: 2.60e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000  136 RIVNKPEFLVAGYELKTTSKEGKNHQDIPAFWQEYLQK-DLGTTIPNRKdtsqwvELGLCTDFNLETGDFTYIIGMEVTD 214
Cdd:pfam14526   1 EIVELPSFTVAGIRYEGPNEYEDHNKEIGKFWEEFNEDgRLPNIKKDDK------SYGIYVDYEDEENEFDYYAGVEVPS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000  215 FENVPNEIAKRTFPAATYAVFTTPKVPHEEmvssIHQTWNAVFSEWFPHSGYEHCGVTEFELYdercHEDKSEFAQVELW 294
Cdd:pfam14526  75 FSELPEGLVVIEIPGGKYAVFTIEGDFPDA----IAEAWTRIYGWLLPNSGYERAGGPDFEVY----KENGDENMKIELY 146


                  ...
gi 446369000  295 IPV 297
Cdd:pfam14526 147 IPV 149
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
15-107 3.38e-30

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 114.49  E-value: 3.38e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000  15 IEEDVMEKQTLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHGFQSHETFTRAFK 94
Cdd:COG2207  161 LLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFK 240

                         90
                 ....*....|...
gi 446369000  95 KLFQMTPSEYRKQ 107
Cdd:COG2207  241 KRFGVTPSEYRKR 253
HTH_18 pfam12833
Helix-turn-helix domain;
28-107 2.28e-27

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 101.51  E-value: 2.28e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   28 LARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSH-TDEKVIDIAFEHGFQSHETFTRAFKKLFQMTPSEYRK 106
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 446369000  107 Q 107
Cdd:pfam12833  81 R 81
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
3-107 5.10e-21

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 85.75  E-value: 5.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   3 SYETQIQRSIDYIEEDVMEKQTLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHG 82
Cdd:PRK10219   2 SHQKIIQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLG 81

                         90       100
                 ....*....|....*....|....*
gi 446369000  83 FQSHETFTRAFKKLFQMTPSEYRKQ 107
Cdd:PRK10219  82 YVSQQTFSRVFRRQFDRTPSDYRHR 106
 
Name Accession Description Interval E-value
YdeE COG3708
Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription] ...
 133-298 1.81e-55

Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription];


Pssm-ID: 442922  Cd Length: 157  Bit Score: 176.75  E-value: 1.81e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000 133 MEYRIVNKPEFLVAGYELKTTSKEGKNHQDIPAFWQEYLQKDLGTtIPNRKDTSqwVELGLCTDFNLETGDFTYIIGMEV 212
Cdd:COG3708    1 MEYRIVEKPAFKLVGLSARTSNSDEEANEEIPALWQRFLPEGLAE-IPNLSNPG--GLYGVCTDYESDEGEFDYLAGVEV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000 213 TDFENVPNEIAKRTFPAATYAVFTTPKvpheEMVSSIHQTWNAVFSEWFPHSGYEHCGVTEFELYDERCheDKSEFAQVE 292
Cdd:COG3708   78 SSFDEVPEGLETLEIPAGTYAVFTHKG----PMPEALQETWQYIYSEWLPSSGYERADGPDFEVYDERD--DPSPDSEVE 151


                 ....*.
gi 446369000 293 LWIPVK 298
Cdd:COG3708  152 IWIPIK 157
AraC_E_bind smart00871
Bacterial transcription activator, effector binding domain; This domain is found in the ...
 134-298 1.30e-36

Bacterial transcription activator, effector binding domain; This domain is found in the probable effector binding domain of a number of different bacterial transcription activators.and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.


Pssm-ID: 214874 [Multi-domain]  Cd Length: 158  Bit Score: 128.36  E-value: 1.30e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   134 EYRIVNKPEFLVAGYELKTTSKEgknhQDIPAFWQEYLQKDLGTTIPNRKDTSQWVELGLCTDFNLETGDFTYIIGMEVT 213
Cdd:smart00871   1 EVRIVELPAFKVAGLRHRGPNED----EKIPELWQRLIQWAKELGLLPVGNSGEPYGVYYDDPDDTPDGEFRYDAGVEVS 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   214 DFENVPNEIAKRTFPAATYAVFTTPKVPHEEmvssIHQTWNAVFSEWFPHSGYEH-CGVTEFELYDERCHEDKSEFAQVE 292
Cdd:smart00871  77 DEVEAPEGVETKTIPAGKYAVFTHKGGSYDE----IQEAWEAIYGEWLPNSGYELrDAGPDFEVYLNDPPDTDPEELVTE 152


                   ....*.
gi 446369000   293 LWIPVK 298
Cdd:smart00871 153 IYIPVK 158
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
24-105 2.10e-31

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 112.26  E-value: 2.10e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000    24 TLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHGFQSHETFTRAFKKLFQMTPSE 103
Cdd:smart00342   3 TLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSE 82


                   ..
gi 446369000   104 YR 105
Cdd:smart00342  83 YR 84
Cass2 pfam14526
Integron-associated effector binding protein; This family contains Cass2 from Vibrio cholerae, ...
 136-297 2.60e-31

Integron-associated effector binding protein; This family contains Cass2 from Vibrio cholerae, an integron-associated protein that has been shown to bind cationic drug compounds with submicromolar affinity. Cass2 has been proposed to be representative of a larger family of independent effector-binding proteins associated with lateral gene transfer within Vibrio and other closely-related species.


Pssm-ID: 434016 [Multi-domain]  Cd Length: 149  Bit Score: 114.38  E-value: 2.60e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000  136 RIVNKPEFLVAGYELKTTSKEGKNHQDIPAFWQEYLQK-DLGTTIPNRKdtsqwvELGLCTDFNLETGDFTYIIGMEVTD 214
Cdd:pfam14526   1 EIVELPSFTVAGIRYEGPNEYEDHNKEIGKFWEEFNEDgRLPNIKKDDK------SYGIYVDYEDEENEFDYYAGVEVPS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000  215 FENVPNEIAKRTFPAATYAVFTTPKVPHEEmvssIHQTWNAVFSEWFPHSGYEHCGVTEFELYdercHEDKSEFAQVELW 294
Cdd:pfam14526  75 FSELPEGLVVIEIPGGKYAVFTIEGDFPDA----IAEAWTRIYGWLLPNSGYERAGGPDFEVY----KENGDENMKIELY 146


                  ...
gi 446369000  295 IPV 297
Cdd:pfam14526 147 IPV 149
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
15-107 3.38e-30

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 114.49  E-value: 3.38e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000  15 IEEDVMEKQTLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHGFQSHETFTRAFK 94
Cdd:COG2207  161 LLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFK 240

                         90
                 ....*....|...
gi 446369000  95 KLFQMTPSEYRKQ 107
Cdd:COG2207  241 KRFGVTPSEYRKR 253
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 5-117 3.79e-28

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 111.30  E-value: 3.79e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   5 ETQIQRSIDYIEEDVMEKQTLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLsHTDEKVIDIAFEHGFQ 84
Cdd:COG2169   83 ADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLL-QTGLSVTDAAYAAGFG 161

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446369000  85 SHETFTRAFKKLFQMTPSEYRKQEIETPMYYRV 117
Cdd:COG2169  162 SLSRFYEAFKKLLGMTPSAYRRGGAGAAIRFAP 194
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 8-107 1.32e-27

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 109.09  E-value: 1.32e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   8 IQRSIDYIEEDVMEKQTLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHGFQSHE 87
Cdd:COG4977  212 LARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSAS 291

                         90       100
                 ....*....|....*....|
gi 446369000  88 TFTRAFKKLFQMTPSEYRKQ 107
Cdd:COG4977  292 HFRRAFRRRFGVSPSAYRRR 311
HTH_18 pfam12833
Helix-turn-helix domain;
28-107 2.28e-27

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 101.51  E-value: 2.28e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   28 LARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSH-TDEKVIDIAFEHGFQSHETFTRAFKKLFQMTPSEYRK 106
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 446369000  107 Q 107
Cdd:pfam12833  81 R 81
GyrI-like pfam06445
GyrI-like small molecule binding domain; This family contains the small molecule binding ...
 134-297 1.21e-26

GyrI-like small molecule binding domain; This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.


Pssm-ID: 428947  Cd Length: 153  Bit Score: 102.10  E-value: 1.21e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000  134 EYRIVNKPEFLVAGYELKTTSkegkNHQDIPAFWQEYLQKDLGTTIPNRKDTSqwveLGLCTDF--NLETGDFTYIIGME 211
Cdd:pfam06445   1 EVEIVELPAFRVAGLRHRGPY----NEEGIGALWEELCAWASENGLSPAPSPL----IGVSYDDpeVTEDEELRYDAGVA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000  212 VTDFENVPNEIAKRTFPAATYAVFTtpkvpHEEMVSSIHQTWNAVFSEWFPHSGYEHCGVTEFELYDERCHEDKSEFAQV 291
Cdd:pfam06445  73 VPIPVEGPEGVEELELPGGEYAVFR-----HKGPYDDLQETYAKIYGEWLPESGYERRDGPSFEIYLNDPREVPEEELKT 147


                  ....*.
gi 446369000  292 ELWIPV 297
Cdd:pfam06445 148 EIYIPV 153
SbmC COG3449
DNA gyrase inhibitor GyrI/SbmC [Replication, recombination and repair];
1-299 6.60e-25

DNA gyrase inhibitor GyrI/SbmC [Replication, recombination and repair];


Pssm-ID: 442672 [Multi-domain]  Cd Length: 286  Bit Score: 101.09  E-value: 6.60e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   1 MESYETQIQRSIDYIEEDVMEKQTLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFE 80
Cdd:COG3449    7 READQRRRILLVLIALHDDLDLLLLALLLAFAFHFFFFHRRRRFRALIGRRARLLLRRRLLAALALLLLSSSAIIAAAAA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000  81 HGFQSHETFTRAFKKLFQMTPSEYRKQEIETPMYYRVNVKQRKLNPylggiqMEYRIVNKPEFLVAGYELKttskeGkNH 160
Cdd:COG3449   87 ASGYSSSASFRRFFRAFGGSSRSRRRRAKAKLLALPPLDPPRLEPM------MDVEIKELPPRRVAYLRHR-----G-PY 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000 161 QDIPAFWQEYLQ----KDLGTtipnrkDTSQWVelGLCTDFNLET--GDFTYIIGMEVTDFENVPNEIAKRTFPAATYAV 234
Cdd:COG3449  155 EEIGEAFERLIAwakaRGLLP------PDSRTI--GIYYDDPDITppEKLRYDACVTVPEDVALPGGVEVKTIPGGRYAV 226

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446369000 235 FTTpKVPHEEmvssIHQTWNAVFSEWFPHSGYEHCGVTEFELYDERCHEDKSEFAQVELWIPVKK 299
Cdd:COG3449  227 LRH-KGPYED----LGAAWDWLYGEWLPASGYELRDRPCFEIYLNDPRETPEGELITDIYLPLKP 286
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
3-107 5.10e-21

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 85.75  E-value: 5.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   3 SYETQIQRSIDYIEEDVMEKQTLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHG 82
Cdd:PRK10219   2 SHQKIIQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLG 81

                         90       100
                 ....*....|....*....|....*
gi 446369000  83 FQSHETFTRAFKKLFQMTPSEYRKQ 107
Cdd:PRK10219  82 YVSQQTFSRVFRRQFDRTPSDYRHR 106
PRK15121 PRK15121
MDR efflux pump AcrAB transcriptional activator RobA;
24-108 4.89e-20

MDR efflux pump AcrAB transcriptional activator RobA;


Pssm-ID: 185076 [Multi-domain]  Cd Length: 289  Bit Score: 87.76  E-value: 4.89e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000  24 TLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHGFQSHETFTRAFKKLFQMTPSE 103
Cdd:PRK15121  23 SLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKAAVALRLTSRPILDIALQYRFDSQQTFTRAFKKQFAQTPAL 102


                 ....*
gi 446369000 104 YRKQE 108
Cdd:PRK15121 103 YRRSP 107
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 2-107 3.27e-17

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 80.08  E-value: 3.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   2 ESYETQIQRSIDYIEEDVMEKQtLR--NLARVAGFSESHFHRVFqALVGDTVMEYVRKRRLARAAYQLSH--TDEKVIDI 77
Cdd:PRK09685 193 PRRERQFQKVVALIDQSIQEEI-LRpeWIAGELGISVRSLYRLF-AEQGLVVAQYIRNRRLDRCADDLRPaaDDEKITSI 270

                         90       100       110
                 ....*....|....*....|....*....|
gi 446369000  78 AFEHGFQSHETFTRAFKKLFQMTPSEYRKQ 107
Cdd:PRK09685 271 AYKWGFSDSSHFSTAFKQRFGVSPGEYRRK 300
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
8-105 6.46e-16

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 72.83  E-value: 6.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   8 IQRSIDYIEEDVMEKQTLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHGFQSHE 87
Cdd:PRK11511  11 IHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQ 90

                         90
                 ....*....|....*...
gi 446369000  88 TFTRAFKKLFQMTPSEYR 105
Cdd:PRK11511  91 TLTRTFKNYFDVPPHKYR 108
ftrA PRK09393
transcriptional activator FtrA; Provisional
 12-107 7.81e-16

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 76.54  E-value: 7.81e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000  12 IDYIEEDVMEKQTLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHGFQSHETFTR 91
Cdd:PRK09393 224 IDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESLRH 303

                         90
                 ....*....|....*.
gi 446369000  92 AFKKLFQMTPSEYRKQ 107
Cdd:PRK09393 304 HFRRRAATSPAAYRKR 319
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
5-107 1.00e-09

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 58.15  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   5 ETQIQRSIDYIEEDVMEKQTLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHGFQ 84
Cdd:PRK13503 170 DARLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFG 249

                         90       100
                 ....*....|....*....|...
gi 446369000  85 SHETFTRAFKKLFQMTPSEYRKQ 107
Cdd:PRK13503 250 DSNHFSTLFRREFSWSPRDIRQG 272
PRK10371 PRK10371
transcriptional regulator MelR;
8-110 2.85e-09

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 57.14  E-value: 2.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   8 IQRSIDYIEEDVMEKQTLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHGFQSHE 87
Cdd:PRK10371 193 VSQMLGFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSS 272

                         90       100
                 ....*....|....*....|...
gi 446369000  88 TFTRAFKKLFQMTPSEYRKQEIE 110
Cdd:PRK10371 273 RFYSTFGKYVGMSPQQYRKLSQQ 295
PRK10296 PRK10296
DNA-binding transcriptional regulator ChbR; Provisional
 25-107 9.67e-09

DNA-binding transcriptional regulator ChbR; Provisional


Pssm-ID: 182362 [Multi-domain]  Cd Length: 278  Bit Score: 55.15  E-value: 9.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000  25 LRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHGFQSHETFTRAFKKLFQMTPSEY 104
Cdd:PRK10296 191 LENMVRLSGKSQEYLTRATRRYYGKTPMQIINEIRINFAKKQLEMTNYSVTDIAFEAGYSSPSLFIKTFKKLTSFTPGSY 270


                 ...
gi 446369000 105 RKQ 107
Cdd:PRK10296 271 RKK 273
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
34-112 7.58e-07

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 49.52  E-value: 7.58e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446369000  34 FSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHGFQSHETFTRAFKKLFQMTPSEYRKQEIETP 112
Cdd:PRK13501 204 LVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQRFIRSP 282
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
3-105 8.10e-07

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 49.72  E-value: 8.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   3 SYETQIQRSIDYIEEDVMEKQTLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHG 82
Cdd:PRK13500 203 SSETLLDKLITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECG 282

                         90       100
                 ....*....|....*....|...
gi 446369000  83 FQSHETFTRAFKKLFQMTPSEYR 105
Cdd:PRK13500 283 FEDSNYFSVVFTRETGMTPSQWR 305
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
3-105 1.46e-06

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 48.90  E-value: 1.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   3 SYETQIQRSIDYIEEDVMEKQTLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHG 82
Cdd:PRK13502 173 SRETLLDKLITALANSLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCG 252

                         90       100
                 ....*....|....*....|...
gi 446369000  83 FQSHETFTRAFKKLFQMTPSEYR 105
Cdd:PRK13502 253 FEDSNYFSVVFTRETGMTPSQWR 275
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
9-115 1.71e-06

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 48.64  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000   9 QRSIDYIEE--DVMEKQ---TLRNLARVAGFSESHFHRVFQALVGDTVMEY---VRKRRLaRAAyqLSHtDEKVIDIAFE 80
Cdd:PRK15435  81 QHRLDKITHacRLLEQEtpvTLEALADQVAMSPFHLHRLFKATTGMTPKAWqqaWRARRL-REA--LAK-GESVTTSILN 156

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446369000  81 HGFQSHETFTRAFKKLFQMTPSEYRKQEIETPMYY 115
Cdd:PRK15435 157 AGFPDSSSYYRKADETLGMTAKQFRHGGENLAVRY 191
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 15-56 1.87e-06

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 44.07  E-value: 1.87e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 446369000   15 IEEDVMEKQTLRNLARVAGFSESHFHRVFQALVGDTVMEYVR 56
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 69-106 3.31e-06

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 43.30  E-value: 3.31e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 446369000   69 HTDEKVIDIAFEHGFqSHETFTRAFKKLFQMTPSEYRK 106
Cdd:pfam00165   6 STNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
13-112 1.65e-05

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 45.35  E-value: 1.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000  13 DYIEEDVMEKQTLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHGFQSHETFTRA 92
Cdd:PRK10572 190 QYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRV 269

                         90       100
                 ....*....|....*....|
gi 446369000  93 FKKLFQMTPSEYRKQEIETP 112
Cdd:PRK10572 270 FKKCTGASPSEFRARCEEKN 289
PRK15340 PRK15340
AraC family transcriptional regulator InvF;
24-101 2.01e-04

AraC family transcriptional regulator InvF;


Pssm-ID: 185240  Cd Length: 216  Bit Score: 41.89  E-value: 2.01e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446369000  24 TLRNLARVAGFSESHFHRVFQALVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHGFQSHETFTRAFKKLFQMTP 101
Cdd:PRK15340 127 TMRMLGEDYGVSYTHFRRLCSRALGGKAKSELRNWRMAQSLLNSVEGHENITQLAVNHGYSSPSHFSSEIKELIGVSP 204
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 15-104 9.41e-03

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 36.97  E-value: 9.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446369000  15 IEEDVMEKQTLRNLARVAGFSESHFHRVFQAlVGDTVMEYVRKRRLARAAYQLSHTDEKVIDIAFEHGFQSHETFTRAFK 94
Cdd:PRK15186 190 IISDISRKWALKDISDSLYMSCSTLKRKLKQ-ENTSFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFK 268

                         90
                 ....*....|
gi 446369000  95 KLFQMTPSEY 104
Cdd:PRK15186 269 KHFKTTPSEF 278
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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