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Conserved domains on  [gi|446372232|ref|WP_000450087|]
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MULTISPECIES: sodium-dependent transporter [Bacillus]

Protein Classification

sodium-dependent transporter( domain architecture ID 10179393)

sodium-dependent transporter similar to Symbiobacterium thermophilum TnaT, a sodium-dependent tryptophan transporter; belongs to the solute carrier 6 (SLC6) family

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SLC6sbd_u1 cd10334
uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; SLC6 ...
4-483 0e+00

uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter.


:

Pssm-ID: 271366 [Multi-domain]  Cd Length: 480  Bit Score: 707.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:cd10334    1 REQWGSRAGFILAAIGSAVGLGNIWRFPYVAYENGGGAFLIPYLIALLTAGIPLLILEYGLGHKYRGSAPLAFRRLNKKF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAITGAWGKDTQSFLFKEYLHVADKPGQFGGLVPEVLIPLALVWIIVLGV 163
Cdd:cd10334   81 EWIGWWQVLVAFVIATYYAVIIAWALSYLFFSFTLAWGDDPEAFFFGDFLQLSDSPFDLGGIVWPILIALVLVWLIIWFI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 164 AFKGVKKGIEVVNRIFIPLLVVMFLIIVVRAVTMEGAMQGLDAFFKPDWSRIFDGKVWLAAYGQIFFSLSLAFGIMITYS 243
Cdd:cd10334  161 LYRGVKKGIEKASKIFMPLLFVLFLILVIRALTLPGAADGLNALFTPDWSALLDPKVWIAAYGQIFFSLSLGFGIMITYA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 244 SYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVPVDKVASAGVGLAFVVFPQIINEL-PMSPLFGVLFF 322
Cdd:cd10334  241 SYLPKKSDLTNNALITAFANSGFEILAGIGVFSILGFMAQAQGVPVSEVVSSGIGLAFVAFPKAINLMpPLGALFGVLFF 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 323 LSLTVAGITSLISLAEVCFAAVSEKFSLSREKTIGIMGTLLVLVSLVFATRGGLMFLDVVDYFANNFGLITIALAEVVTI 402
Cdd:cd10334  321 LSLVFAGLTSLISLVEVVISAVQDKFGLSRKKAVTIVCLVGFLVSLLFATGAGLYLLDIVDHFINNYGIVLVGLVEVIVV 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 403 GLILRRLPVyQNHANFVSDIKLGTFWRVSLLVITPLMLGYMLIDGTIQNIKKNYGDYPTEFVITYGWSIAAAFLIVALII 482
Cdd:cd10334  401 GWVFGAEKL-REHLNAVSDFKVGKWWDFLIKVVTPLVLGYMLILGLIGLLTEPYGGYPVWALLLFGWGIVALILVAALLL 479

                 .
gi 446372232 483 S 483
Cdd:cd10334  480 S 480
 
Name Accession Description Interval E-value
SLC6sbd_u1 cd10334
uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; SLC6 ...
4-483 0e+00

uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter.


Pssm-ID: 271366 [Multi-domain]  Cd Length: 480  Bit Score: 707.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:cd10334    1 REQWGSRAGFILAAIGSAVGLGNIWRFPYVAYENGGGAFLIPYLIALLTAGIPLLILEYGLGHKYRGSAPLAFRRLNKKF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAITGAWGKDTQSFLFKEYLHVADKPGQFGGLVPEVLIPLALVWIIVLGV 163
Cdd:cd10334   81 EWIGWWQVLVAFVIATYYAVIIAWALSYLFFSFTLAWGDDPEAFFFGDFLQLSDSPFDLGGIVWPILIALVLVWLIIWFI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 164 AFKGVKKGIEVVNRIFIPLLVVMFLIIVVRAVTMEGAMQGLDAFFKPDWSRIFDGKVWLAAYGQIFFSLSLAFGIMITYS 243
Cdd:cd10334  161 LYRGVKKGIEKASKIFMPLLFVLFLILVIRALTLPGAADGLNALFTPDWSALLDPKVWIAAYGQIFFSLSLGFGIMITYA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 244 SYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVPVDKVASAGVGLAFVVFPQIINEL-PMSPLFGVLFF 322
Cdd:cd10334  241 SYLPKKSDLTNNALITAFANSGFEILAGIGVFSILGFMAQAQGVPVSEVVSSGIGLAFVAFPKAINLMpPLGALFGVLFF 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 323 LSLTVAGITSLISLAEVCFAAVSEKFSLSREKTIGIMGTLLVLVSLVFATRGGLMFLDVVDYFANNFGLITIALAEVVTI 402
Cdd:cd10334  321 LSLVFAGLTSLISLVEVVISAVQDKFGLSRKKAVTIVCLVGFLVSLLFATGAGLYLLDIVDHFINNYGIVLVGLVEVIVV 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 403 GLILRRLPVyQNHANFVSDIKLGTFWRVSLLVITPLMLGYMLIDGTIQNIKKNYGDYPTEFVITYGWSIAAAFLIVALII 482
Cdd:cd10334  401 GWVFGAEKL-REHLNAVSDFKVGKWWDFLIKVVTPLVLGYMLILGLIGLLTEPYGGYPVWALLLFGWGIVALILVAALLL 479

                 .
gi 446372232 483 S 483
Cdd:cd10334  480 S 480
YocR COG0733
Na+-dependent transporter, SNF family [General function prediction only];
1-447 5.77e-162

Na+-dependent transporter, SNF family [General function prediction only];


Pssm-ID: 440497 [Multi-domain]  Cd Length: 444  Bit Score: 466.50  E-value: 5.77e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   1 METRQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRIS 80
Cdd:COG0733    2 SSKREQWSSRLGFILAAAGSAVGLGNIWRFPYVAGENGGGAFLLPYLLALLLIGIPLLIAEFAIGRRGRKSPVGAFRKLA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  81 P--RAEFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAITGAWGKDTqsflfkeylhVADKPGQFGGLV---PEVLIPLAL 155
Cdd:COG0733   82 PgkKWEWIGWLGVLGAFLILSYYSVVAGWVLAYLFKSLTGAFGGLD----------AEDAGAFFGAFLsspGEVLIWHLL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 156 VWIIVLGVAFKGVKKGIEVVNRIFIPLLVVMFLIIVVRAVTMEGAMQGLDAFFKPDWSRIFDGKVWLAAYGQIFFSLSLA 235
Cdd:COG0733  152 FLLLTALIVARGVQKGIEKASKILMPLLFVLLIILVIRALTLPGAAEGLKFLFTPDFSKLTDPEVWLAALGQAFFSLSLG 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 236 FGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALgFMANnmgvpVDkvASAGVGLAFVVFPQIINELPMSP 315
Cdd:COG0733  232 MGIMITYGSYLPKDEDLPRSALIVALLDTLVALLAGLAIFPAV-FAFG-----LE--PAAGPGLAFVTLPAVFAQMPGGR 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 316 LFGVLFFLSLTVAGITSLISLAEVCFAAVSEKFSLSREKTIGIMGTLLVLVSLVFAT------RGGLMFLDVVDYFANNF 389
Cdd:COG0733  304 LFGVLFFLLLLFAALTSAISLLEVVVAALIDKFGLSRKKATLIVGLLIFLLGIPSALsfnvsvTIGLTFFDLVDFLVSNI 383
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446372232 390 GLITIALAEVVTIGLILRRlPVYQNHANFVSDIKLGTFWRVSLLVITPLMLGYMLIDG 447
Cdd:COG0733  384 LLPLGGLLIAIFVGWVLGK-EKLREELNAGSDIKLGKWWRFLIRYVAPVALLIIFLNG 440
SNF pfam00209
Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.
4-487 1.35e-130

Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.


Pssm-ID: 395155 [Multi-domain]  Cd Length: 517  Bit Score: 389.34  E-value: 1.35e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232    4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:pfam00209   1 RETWSGKLDFLLSVIGFAVGLGNVWRFPYLCYKNGGGAFLIPYLIMLIFAGIPLFFLELALGQYTREGAIGVWRKICPLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAITG--AWGKDTQS---------------------------FLFKEYLH 134
Cdd:pfam00209  81 KGIGYASMVIAFYIGIYYNVIIAWALYYLFSSFTTelPWASCNNSwntpncteffsannttnslnktspveeFWERKVLK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  135 VADKPGQFGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVnrIFIPLL-VVMFLIIVVRAVTMEGAMQGLDAFFKPDWS 213
Cdd:pfam00209 161 LSDGIEDLGGLRWPLALCLLVAWVVVYFCIWKGVKSSGKVV--YFTATFpYVVLLVLLVRGVTLPGAADGILFYLTPDWS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  214 RIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVPVDKVA 293
Cdd:pfam00209 239 KLLEPQVWIDAATQIFFSLGIGFGGLIAFASYNKFHNNCYRDALIVSFINSATSFLAGFVIFSVLGFMAQEQGVPISEVA 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  294 SAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKF----SLSREKTIGIMGTLLVLVSLV 369
Cdd:pfam00209 319 ESGPGLAFIAYPEAVTMLPLSPFWSVLFFLMLITLGLDSQFGGVEGIITALVDEFpillRKRRELFTLIVCVASFLLGLI 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  370 FATRGGLMFLDVVDYFANNFGLITIALAEVVTIGLI--LRRlpvYQNHANFVSDIKLGTFWRVSLLVITPLMLGYMLIDG 447
Cdd:pfam00209 399 LVTEGGIYVFTLFDYYAASFSLLFVAFFECIAIAWVygIDR---FYDDIKEMLGFRPGLFWRLCWKFVSPLILLFLFIFS 475
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 446372232  448 TIQNIKKNYGDY--PTeFVITYGWSIAAAFLIVALIISLKKW 487
Cdd:pfam00209 476 IVQYQPLTYNNYvyPN-WANALGWLMALSSMLCIPLYSIYKL 516
Na_transp NF037979
sodium-dependent transporter;
13-369 3.58e-16

sodium-dependent transporter;


Pssm-ID: 468298 [Multi-domain]  Cd Length: 417  Bit Score: 80.36  E-value: 3.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  13 FIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRgsAPLTFFRISPRAEFI--GWWQ 90
Cdd:NF037979   7 LIFLVAGYAVGIGTFWLFPQFWLQYGLTGLVVYLIFLAVLTYLAILEAESTKKSRYY--IVELYTKVARTPAMIlvLLMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  91 MCVTFIVSTYYAVIIAWSISYTYFAITGAwgkdtqsflfkeylhvadkpgqfgglvpeVLIPLALVWIIVLGVAFKGVKK 170
Cdd:NF037979  85 LVIFLGVISYYTANGGLLLSPILGTGTLG-----------------------------ILIAKLLMILLAFLILTRAKEK 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 171 GIEVVNRIFI-PLLVVMFLIIVVRAVTMEGAMQGLdAFFKPDWSRIFDG-----KVWLAAYGQIFFSLSLAFGIMITYSS 244
Cdd:NF037979 136 TLDIMAIGSVlFVIFVVVSAILFRSQVLSVAPQAA-QYLSMAKSMIFSFhpitlKLVVDMALQAIYSLGLGFGFYLVLGS 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 245 YLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVPVDKVASAGVGLAFVVFPQIINELPMSPLFGVLFFLS 324
Cdd:NF037979 215 FLPERFNAKKIIGIGILLQTLLSFLATFTVVYSLGPAHPGYLTAFVYGGEEEAISLFYSLPLILRDVPGGPTLLYLLMLS 294
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 446372232 325 LTVAGITSLISLAEVCFAAVSEKFSLSREKTIGIMGTLLVLVSLV 369
Cdd:NF037979 295 LFLAGLTSILPLGEVGGQIISEVFQLGRNKALIYVLGISLVLGGI 339
 
Name Accession Description Interval E-value
SLC6sbd_u1 cd10334
uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; SLC6 ...
4-483 0e+00

uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter.


Pssm-ID: 271366 [Multi-domain]  Cd Length: 480  Bit Score: 707.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:cd10334    1 REQWGSRAGFILAAIGSAVGLGNIWRFPYVAYENGGGAFLIPYLIALLTAGIPLLILEYGLGHKYRGSAPLAFRRLNKKF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAITGAWGKDTQSFLFKEYLHVADKPGQFGGLVPEVLIPLALVWIIVLGV 163
Cdd:cd10334   81 EWIGWWQVLVAFVIATYYAVIIAWALSYLFFSFTLAWGDDPEAFFFGDFLQLSDSPFDLGGIVWPILIALVLVWLIIWFI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 164 AFKGVKKGIEVVNRIFIPLLVVMFLIIVVRAVTMEGAMQGLDAFFKPDWSRIFDGKVWLAAYGQIFFSLSLAFGIMITYS 243
Cdd:cd10334  161 LYRGVKKGIEKASKIFMPLLFVLFLILVIRALTLPGAADGLNALFTPDWSALLDPKVWIAAYGQIFFSLSLGFGIMITYA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 244 SYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVPVDKVASAGVGLAFVVFPQIINEL-PMSPLFGVLFF 322
Cdd:cd10334  241 SYLPKKSDLTNNALITAFANSGFEILAGIGVFSILGFMAQAQGVPVSEVVSSGIGLAFVAFPKAINLMpPLGALFGVLFF 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 323 LSLTVAGITSLISLAEVCFAAVSEKFSLSREKTIGIMGTLLVLVSLVFATRGGLMFLDVVDYFANNFGLITIALAEVVTI 402
Cdd:cd10334  321 LSLVFAGLTSLISLVEVVISAVQDKFGLSRKKAVTIVCLVGFLVSLLFATGAGLYLLDIVDHFINNYGIVLVGLVEVIVV 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 403 GLILRRLPVyQNHANFVSDIKLGTFWRVSLLVITPLMLGYMLIDGTIQNIKKNYGDYPTEFVITYGWSIAAAFLIVALII 482
Cdd:cd10334  401 GWVFGAEKL-REHLNAVSDFKVGKWWDFLIKVVTPLVLGYMLILGLIGLLTEPYGGYPVWALLLFGWGIVALILVAALLL 479

                 .
gi 446372232 483 S 483
Cdd:cd10334  480 S 480
YocR COG0733
Na+-dependent transporter, SNF family [General function prediction only];
1-447 5.77e-162

Na+-dependent transporter, SNF family [General function prediction only];


Pssm-ID: 440497 [Multi-domain]  Cd Length: 444  Bit Score: 466.50  E-value: 5.77e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   1 METRQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRIS 80
Cdd:COG0733    2 SSKREQWSSRLGFILAAAGSAVGLGNIWRFPYVAGENGGGAFLLPYLLALLLIGIPLLIAEFAIGRRGRKSPVGAFRKLA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  81 P--RAEFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAITGAWGKDTqsflfkeylhVADKPGQFGGLV---PEVLIPLAL 155
Cdd:COG0733   82 PgkKWEWIGWLGVLGAFLILSYYSVVAGWVLAYLFKSLTGAFGGLD----------AEDAGAFFGAFLsspGEVLIWHLL 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 156 VWIIVLGVAFKGVKKGIEVVNRIFIPLLVVMFLIIVVRAVTMEGAMQGLDAFFKPDWSRIFDGKVWLAAYGQIFFSLSLA 235
Cdd:COG0733  152 FLLLTALIVARGVQKGIEKASKILMPLLFVLLIILVIRALTLPGAAEGLKFLFTPDFSKLTDPEVWLAALGQAFFSLSLG 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 236 FGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALgFMANnmgvpVDkvASAGVGLAFVVFPQIINELPMSP 315
Cdd:COG0733  232 MGIMITYGSYLPKDEDLPRSALIVALLDTLVALLAGLAIFPAV-FAFG-----LE--PAAGPGLAFVTLPAVFAQMPGGR 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 316 LFGVLFFLSLTVAGITSLISLAEVCFAAVSEKFSLSREKTIGIMGTLLVLVSLVFAT------RGGLMFLDVVDYFANNF 389
Cdd:COG0733  304 LFGVLFFLLLLFAALTSAISLLEVVVAALIDKFGLSRKKATLIVGLLIFLLGIPSALsfnvsvTIGLTFFDLVDFLVSNI 383
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446372232 390 GLITIALAEVVTIGLILRRlPVYQNHANFVSDIKLGTFWRVSLLVITPLMLGYMLIDG 447
Cdd:COG0733  384 LLPLGGLLIAIFVGWVLGK-EKLREELNAGSDIKLGKWWRFLIRYVAPVALLIIFLNG 440
SNF pfam00209
Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.
4-487 1.35e-130

Sodium:neurotransmitter symporter family; These are twelve xTM-containing region transporters.


Pssm-ID: 395155 [Multi-domain]  Cd Length: 517  Bit Score: 389.34  E-value: 1.35e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232    4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:pfam00209   1 RETWSGKLDFLLSVIGFAVGLGNVWRFPYLCYKNGGGAFLIPYLIMLIFAGIPLFFLELALGQYTREGAIGVWRKICPLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAITG--AWGKDTQS---------------------------FLFKEYLH 134
Cdd:pfam00209  81 KGIGYASMVIAFYIGIYYNVIIAWALYYLFSSFTTelPWASCNNSwntpncteffsannttnslnktspveeFWERKVLK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  135 VADKPGQFGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVnrIFIPLL-VVMFLIIVVRAVTMEGAMQGLDAFFKPDWS 213
Cdd:pfam00209 161 LSDGIEDLGGLRWPLALCLLVAWVVVYFCIWKGVKSSGKVV--YFTATFpYVVLLVLLVRGVTLPGAADGILFYLTPDWS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  214 RIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVPVDKVA 293
Cdd:pfam00209 239 KLLEPQVWIDAATQIFFSLGIGFGGLIAFASYNKFHNNCYRDALIVSFINSATSFLAGFVIFSVLGFMAQEQGVPISEVA 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  294 SAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKF----SLSREKTIGIMGTLLVLVSLV 369
Cdd:pfam00209 319 ESGPGLAFIAYPEAVTMLPLSPFWSVLFFLMLITLGLDSQFGGVEGIITALVDEFpillRKRRELFTLIVCVASFLLGLI 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  370 FATRGGLMFLDVVDYFANNFGLITIALAEVVTIGLI--LRRlpvYQNHANFVSDIKLGTFWRVSLLVITPLMLGYMLIDG 447
Cdd:pfam00209 399 LVTEGGIYVFTLFDYYAASFSLLFVAFFECIAIAWVygIDR---FYDDIKEMLGFRPGLFWRLCWKFVSPLILLFLFIFS 475
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 446372232  448 TIQNIKKNYGDY--PTeFVITYGWSIAAAFLIVALIISLKKW 487
Cdd:pfam00209 476 IVQYQPLTYNNYvyPN-WANALGWLMALSSMLCIPLYSIYKL 516
SLC6sbd cd10324
Solute carrier 6 family, neurotransmitter transporters; solute-binding domain; This family ...
5-445 1.04e-128

Solute carrier 6 family, neurotransmitter transporters; solute-binding domain; This family represents the solute-binding domain of SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family). These use sodium and chloride electrochemical gradients to catalyze the thermodynamically uphill movement of a variety of substrates, and include neurotransmitter transporters (NTTs). The latter are Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NTTs are widely expressed in the mammalian brain, and are involved in regulating neurotransmitter signaling and homeostasis, through facilitating the uptake of released neurotransmitters from the extracellular space into neurons and glial cells. NTTs are the target of a range of therapeutic drugs for the treatment of psychiatric diseases, such as major depression, anxiety disorders, attention deficit hyperactivity disorder and epilepsy. In addition, they are the primary targets of cocaine, amphetamines and other psychostimulants. This family also includes Drosophila Blot which is expressed primarily in epithelial tissues of ectodermal origin and in the nervous system of the embryo and larvae, but in addition found in the developing oocyte and the freshly laid egg. A lack or reduction of Blot function during oogenesis results in early arrest of embryonic development. 12 transmembrane helices (TMs) appears to be common for eukaryotic and some prokaryotic and archaeal SLC6s, (a core inverted topology repeat, TM1-5 and TM6-10, plus TMs11-12; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT), although a majority of bacterial, and some archaeal SLC6s lack TM12, for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.


Pssm-ID: 271359 [Multi-domain]  Cd Length: 415  Bit Score: 380.72  E-value: 1.04e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   5 QQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRAE 84
Cdd:cd10324    1 EQWGSKLEFLLSCIGYAVGLGNIWRFPYLAYENGGGAFLIPYLIMLFLVGIPLFYLELALGQYTSRGPVGAFWRIAPLFK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  85 FIGWWQMCVTFIVSTYYAVIIAWSISYTYFAItgawgkdtqsflfkeylhvadkpgqfggLVPEVLIPLALVWIIVLgva 164
Cdd:cd10324   81 GVGYAQVLVSFLVAIYYNVIIAWTLYYLFASF----------------------------INWELFLCLLLAWILVY--- 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 165 FKGVKKGIEVVNRIFIPLLVVMFLIIVVRAVTMEGAMQGLDAFFKPDWSRIFDGKVWLAAYGQIFFSLSLAFGIMITYSS 244
Cdd:cd10324  130 LCKGVKSIGKGVKFTGPFPYVLLLFLLIRGVTLPGAGDGILFYLTPDWSKLLDPKVWIAAATQIFFSLGIGFGGLITYAS 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 245 YLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVPVDKVASAGVGLAFVVFPQIINELPMSPLFGVLFFLS 324
Cdd:cd10324  210 YNKFKNNIYRDALIVAILNTLTSLLAGFVIFSILGFLAHEPGTPVEDVVASGPGLAFIVYPEAIAQMPGPQLWSVLFFLM 289
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 325 LTVAGITSLISLAEVCFAAVSEKFSLSREKTI---GIMGTLLVLVSLVFATRGGLMFLDVVDYFANNFGLITIALAEVVT 401
Cdd:cd10324  290 LFLLGLDSQFAMVEVIVTALADEFPKLRKRRWlvtLGVCVVGFLLGLPYTTPGGIYVLDLFDYYAAGFSLLVIALLELIA 369
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 446372232 402 IGLILRRLPVYQNHaNFVSDIKLGTFWRVSLLVITPLMLGYMLI 445
Cdd:cd10324  370 IAWIYGVDRFLEDI-EFMLGIRPSIYWRICWKFITPVVLLIILV 412
SLC6sbd_Tyt1-Like cd10336
solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; SLC6 ...
5-447 5.78e-109

solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, involved in regulating neurotransmitter signaling and homeostasis, and the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter. An arrangement of 12 transmembrane (TM) helices appears to be as a common topological motif for eukaryotic and some prokaryotic and archaeal NTTs. However, this subfamily which contains the majority of bacterial members and some archaeal members, appears to contain only 11 TMs; for example the functional Fusobacterium nucleatum tyrosine transporter Tyt1.


Pssm-ID: 271367 [Multi-domain]  Cd Length: 440  Bit Score: 330.94  E-value: 5.78e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   5 QQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRI---SP 81
Cdd:cd10336    1 EQWSSRLGFILAAAGSAVGLGNIWRFPYLAGENGGGAFLLVYLLFVLLIGLPLLIAEFAIGRRTRKNPVGAFAKLaggGK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  82 RAEFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAITGAWGKDTQsflfkeylhvADKPGQFGGLV---PEVLIPLALVWI 158
Cdd:cd10336   81 KWKLIGWLGVLGGFLILSFYSVVGGWVLKYLFKSLTGLFAGADA----------AEVGAAFFGFIaspLSPLLWHLLFLL 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 159 IVLGVAFKGVKKGIEVVNRIFIPLLVVMFLIIVVRAVTMEGAMQGLDAFFKPDWSRIfDGKVWLAAYGQIFFSLSLAFGI 238
Cdd:cd10336  151 LTALIVARGVKKGIERANKILMPLLFILLIILAIRSLTLPGAGEGLKFLLKPDFSKL-TPEVVLAALGQAFFSLSLGMGV 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 239 MITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALgfMANNMGVpvdkvaSAGVGLAFVVFPQIINELPMSPLFG 318
Cdd:cd10336  230 MITYGSYLSKDENLPKSALIVAVLDTLVALLAGLVIFPAV--FAFGLDP------AAGPGLLFITLPAVFAQMPGGRLFG 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 319 VLFFLSLTVAGITSLISLAEVCFAAVSEKFSLSREKTIGIMGTLLVLVSLVFA---------TRGGLMFLDVVDYFANNF 389
Cdd:cd10336  302 ILFFLLLLFAALTSAISLLEVVVAYLIDEFGWSRKKATLIVGIIIFLLGIPSAlsfgvlsdvTIFGKTFFDLLDFLVSNI 381
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446372232 390 GLITIALAEVVTIGLILRRLPVYQNHANFVSDIKLGTFWRVSLLVITPLMLGYMLIDG 447
Cdd:cd10336  382 LLPLGGLLIAIFVGWVLGKEALLEELNKGGLGKKLFKIWLFLLRYVAPVAILIIFLLG 439
SLC6sbd-TauT-like cd11496
Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding ...
4-460 1.08e-84

Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding domain; This subgroup represents the solute-binding domain of TauT-like Na(+)- and Cl(-)-dependent transporters. Family members include: human TauT which transports taurine, human GAT1, GAT2, and GAT3, and BGT1, which transport gamma-aminobutyric acid (GABA), and human CT1 which transports creatine. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271387  Cd Length: 543  Bit Score: 271.76  E-value: 1.08e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGhRHRGSAPLTFFRISPRA 83
Cdd:cd11496    1 RGKWSNKIDFLLSVAGYAIGLGNVWRFPYLCYKNGGGAFLIPYFIFLVLCGIPIFFLETSLG-QYTSQGGITAWKICPLF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAITG---------AWGKDT---------------------------QSF 127
Cdd:cd11496   80 KGIGYASAVIVFWLNIYYIVILAWALFYLFNSFTSplpwttcdnWWNTECcvefysnnnlsnsrenasnntnatspvEEF 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 128 LFKEYLHVADKPGQFGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVnrIFIPLL-VVMFLIIVVRAVTMEGAMQGLDA 206
Cdd:cd11496  160 WERRVLGISDGIDEIGSIRWELVLCLLLAWVIVYFCIWKGVKSTGKVV--YFTATFpYVMLIILLIRGVTLPGASDGIKF 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 207 FFKPDWSRIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMG 286
Cdd:cd11496  238 YLKPDLTKLLDPQVWIDAGTQIFFSYGIGLGSLTALGSYNKFNNNCYKDSIILCFLNSGTSFFAGFAIFSILGFMAQEQG 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 287 VPVDKVASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKFS------LSREKTIGIMG 360
Cdd:cd11496  318 VPISEVAESGPGLAFIAYPRAVSLLPLPQLWAVLFFIMLLLLGLDSQFVGVEGFVTAIVDLYPrvlrrrYRREIFVAIVC 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 361 TLLVLVSLVFATRGGLMFLDVVDYF-ANNFGLITIALAEVVTIGLILRRLPVYQNHANFVSdIKLGTFWRVSLLVITP-L 438
Cdd:cd11496  398 LVSFLIGLPMVTEGGIYVFQLFDYYaASGICLLWLAFFECIAISWVYGADRFYDNIKDMIG-YRPGPWWKYCWLFGTPaI 476
                        490       500
                 ....*....|....*....|....*
gi 446372232 439 MLG---YMLIDGTIQNIKKNYgDYP 460
Cdd:cd11496  477 CLGifiFSLVKYTPLTYGNTY-VYP 500
SLC6sbd-B0AT-like cd10332
System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding ...
4-482 1.34e-80

System B(0) neutral amino acid transporter AT1, 2 and 3, and related proteins; solute-binding domain; This subgroup includes the solute-binding domain of transmembrane transporters, which transport, i) neutral amino acids: NTT4 (also called XT1), SBAT1 (also called B0AT2, v7-3, NTT7-3), and B0AT1 (also called HND); the human genes encoding these are SLC6A17, SLC6A15, and SLC6A19 respectively, ii) glycine: B0AT3 (also called Xtrp2, XT2), iii) imino acids, such as proline, pipecolate, MeAIB, and sarcosine: SIT1 (also called XTRP3, XT3, IMINO). The human genes encoding B0AT3 and SIT1 are SLC6A18 and SLC6A20 respectively. Transporters in this subgroup may play a role in disorders including major depression, Hartnup disorder, increased susceptibility to myocardial infarction, and iminoglycinuria. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271364  Cd Length: 531  Bit Score: 260.67  E-value: 1.34e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:cd10332    1 RPAWDNKLQFLLATIGYAVGLGNVWRFPYLCQKNGGGAFLIPYFIMLILEGIPLFFLELAIGQRLRKGSIGVWNTISPYL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISY--------------------TYFAITGAWGKDTQSFLFKEYLHVADKPGQFG 143
Cdd:cd10332   81 GGVGIASVVVSFLVALYYNVIIAWCFFYlfnsfqyplpwsscptngngTGYVEECAKSSPTQYFWYRTTLDISPSIDESG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 144 GLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVnrIFIPLLVVMFLII-VVRAVTMEGAMQGLDAFFKPDWSRIFDGKVWL 222
Cdd:cd10332  161 GLNWWMTLCLLLAWIIVYLCMMKGIKSSGKVV--YFTATFPYIVLIIfFIRGLTLKGAGDGLKHMFTPKFEKLLDPQVWL 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 223 AAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVP-------------- 288
Cdd:cd10332  239 DAATQIFFSLGLGFGSLIAFSSYNPPKNNCQRDAVLVSLINCFTSIFASIVVFSVLGFKINNVTLTenqtlgltncsled 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 289 -VDKVASaGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSE---KFSLSREKTIGIMGTLLV 364
Cdd:cd10332  319 eLDEAVQ-GTGLAFIVFTEAITKMPGAPFWSVLFFLMLLTLGLGSMFGTLEGVVTPLFDskiLPKVPKEYLTGLVCLVCF 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 365 LVSLVFATRGGLMFLDVVDYFANNFGLITIALAEVVTIGLI--LRRlpvyqnhanFVSDIKLGT------FWRVSLLVIT 436
Cdd:cd10332  398 LIGLIFTQRSGNYWVQMFDSYAGTLPLLIIALFEMIAVSYVygLDR---------FEEDIEYMTgkrpgwYWKITWRYVS 468
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446372232 437 PLMLGYMLIDGTIQNIKKNYG------DYPTEFVITY-GWSIAAAFLIVALII 482
Cdd:cd10332  469 PLLMLVILVASIIQLITKPPTysawnaELAKTESLPYpNWGLAVIILLILLSI 521
SLC6sbd_PROT cd11500
Na(+)- and Cl(-)-dependent L-proline transporter PROT; solute-binding domain; PROT is a ...
4-459 1.45e-79

Na(+)- and Cl(-)-dependent L-proline transporter PROT; solute-binding domain; PROT is a high-affinity L-proline transporter that transports L-proline, and may have a role in excitatory neurotransmission. Human PROT is encoded by the SLC6A7 gene, a potential susceptible gene for asthma. PROT is expressed in the brain. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271390  Cd Length: 541  Bit Score: 258.14  E-value: 1.45e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGhRHRGSAPLTFFRISPRA 83
Cdd:cd11500    1 RGQWGGKLEFLLSCIGYCVGLGNVWRFPYLCYRNGGGAFLIPYFIMLAFCGIPLFFMELSLG-QYGSLGPLTVWKCCPIF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAITG---------AWGKD---------------------TQSFLFKEYL 133
Cdd:cd11500   80 KGIGYGMLLVSGLVCIYYNVIIAWTLFYLFASFTSvlpwehcgnWWNTEsclehrgngaltvnltrtvspSEEYWNRRVL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 134 HVADKPG--QFGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVnRIFIPLLVVMFLIIVVRAVTMEGAMQGLDAFFKPD 211
Cdd:cd11500  160 GIQGSSGigDPGEVRWELALCLLLAWVIVFFCLFKGVKSSGKVV-YFTATFPYIILIVLLVRGVTLEGALKGIQFYLTPD 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 212 WSRIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVPVDK 291
Cdd:cd11500  239 FHRLASSQVWYDAASQIFYSLGIGFGGLLTMASYNKFNNNIYRDTLIITLGNCITSVFAGFAIFSVLGHMAHELGVPVKD 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 292 VASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKFS--LSREKT--IGIMGTLLVLVS 367
Cdd:cd11500  319 VADAGPGLAFVAYPEALTLLPVSPFWSILFFFMLLTLGLDSQFAMLETIVTAVTDEFPylLRKYKTwfLGLICVGMYLLG 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 368 LVFATRGGLMFLDVVDYFANNFGLITIALAEVVTIGLILRRLPVYQNHANFVSdIKLGTFWRVSLLVITPLMLGYMLIDG 447
Cdd:cd11500  399 LLLVTDGGMYWLTLMDWYSASFGLMVLALFMCLAISWVYGIQRFCRDIKMMIG-FEPNLYFKACWMFISPALLLFILVYS 477
                        490
                 ....*....|..
gi 446372232 448 TIQNIKKNYGDY 459
Cdd:cd11500  478 IVKYQPSEYGSY 489
SLC6sbd_u2 cd11554
uncharacterized eukaryotic solute carrier 6 subfamily; solute-binding domain; SLC6 proteins ...
5-407 2.39e-78

uncharacterized eukaryotic solute carrier 6 subfamily; solute-binding domain; SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporter family or Na+/Cl--dependent transporter family) include neurotransmitter transporters (NTTs): these are sodium- and chloride-dependent plasma membrane transporters for the monoamine neurotransmitters serotonin (5-hydroxytryptamine), dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. These NTTs are widely expressed in the mammalian brain, and are involved in regulating neurotransmitter signaling and homeostasis, and are the target of a range of therapeutic drugs for the treatment of psychiatric diseases. Bacterial members of the SLC6 family include the LeuT amino acid transporter.


Pssm-ID: 212092 [Multi-domain]  Cd Length: 406  Bit Score: 251.08  E-value: 2.39e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   5 QQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRAE 84
Cdd:cd11554    1 DQWGSRTAFVLAAMGGAVGLGNLLRFPSVVYNNGGLQFFIPYLLALVLLAIPILILELALGQAYRGGCVKAFNLINRRAK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  85 FIGWWQMCVTFIVSTYYAVIIAWSISYTYFAITGAWgkdtqsflfkeylhvadkpgqfgglvpevlipLALVWIIVlgva 164
Cdd:cd11554   81 GVGAAVVFGGFVVCTYYVPILAWIMVYFRHSFTVGW--------------------------------LAFTWFVV---- 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 165 FKGVKKGIEVVNR---IFIPLLVVMFLIIVVRAVTMEGAMQGLDAFFKPDWSRIFD-GKVWLAAYGQIFFSLSLAFGIMI 240
Cdd:cd11554  125 WLCVFRGVGSTGRvvyITMGLPIVLIIILLGRGASLPNAGDGIRLYFATWRGDKLAsGEIWQAAAGQVFFSTGVGFGYMT 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 241 TYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMAnnMGVPVDKVASAGVGLAFVVFPQIINELPMSPLFGVL 320
Cdd:cd11554  205 AYASYNSKFSNAVQDALIIAGSNSLFEIIAGFAVFGIVGYLG--MTPGVEGEALGGFVLGFVTYPEAIAQMPGSNFFAVL 282
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 321 FFLSLTVAGITSLISLAE-----VCFAAVSEKFSLSREKTIGIMgtLLVLVSLVFATRGGLMFLDVVDYFANNFGLITIA 395
Cdd:cd11554  283 FFLTLFLLGISSAFALLEavvtlICDSGWGRKVKRWWIATVVCF--VSFLLSLPYCTRFGYYLLDAVDAWISNVALVFVV 360
                        410
                 ....*....|..
gi 446372232 396 LAEVVTIGLILR 407
Cdd:cd11554  361 WAECVAATTVYR 372
LeuT-like_sbd cd10333
Aquifex aeolicus LeuT and related proteins; solute binding domain; LeuT is a bacterial amino ...
4-484 7.23e-78

Aquifex aeolicus LeuT and related proteins; solute binding domain; LeuT is a bacterial amino acid transporter with specificity for the hydrophobic amino acids glycine, alanine, methionine, and leucine. This subgroup belongs to the solute carrier 6 (SLC6) transporter family; LeuT has been used as a structural template for understanding fundamental aspects of SLC6 function. It has an arrangement of 12 transmembrane helices (TMs), which appears to be a common motif for eukaryotic and some prokaryotic and archaeal SLC6s: an inverted topology repeat: TMs1-5 and TMs6-10, and TMs11-12.


Pssm-ID: 271365 [Multi-domain]  Cd Length: 496  Bit Score: 252.62  E-value: 7.23e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALG-----HRHrGSAPLTF-- 76
Cdd:cd10333    1 REHWGSRIGLILAMAGNAVGLGNFLRFPVQAAQNGGGAFMIPYFIAFLLLGIPLMWIEWAMGryggkYGH-GTTPMIFll 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  77 FRISPRAEFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAITGAW------GKDTQSFLfkeYLHVADKPGQFGGLvpeVL 150
Cdd:cd10333   80 AWENRFAKILGAIGLAIPLLVNSYYVYIESWTLGYAFKSLTGAYpeppsiLRPTAEFF---YSYIGKPSGLAYIF---FL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 151 IPLALVWIIVlgvaFKGVKKGIEVVNRIFIPLLVVMFLIIVVRAVTME-------GAMQGLDAFFKPDWSRIFDGKVWLA 223
Cdd:cd10333  154 ITMALNFFIL----YRGVSKGIEAFAKIAMPLLYVFAIILLIRVLTLGspvnpnwTALKGLNFLWNPDFSKLKNPKVWLA 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 224 AYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAG--IGVFAALGFmannMGVPVDKVASAGVGLAF 301
Cdd:cd10333  230 AAGQIFFTLSLGMGIIQNYASYLKKDDDVVLSGLTAASLNEFAEVILGgsIAIPAAFAF----LGVAVAIAKAGGFGLGF 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 302 VVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKFSLSREKTIGIMGTLLVLVSLVFATRGGLMFLDV 381
Cdd:cd10333  306 IALPNVFSQMPGGQFFGFLWFLLLFFAGITSSIAMYQPLIAFLEEELGISRKHAAWVVFAIVFFLGLPVVLEFDLKALDE 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 382 VDYFANNFGLITIALAEVVTIGLILRRLPVYqNHANFVSDIKLGTFWRVSLLVITPLMLGYMLIDGTIQNIKKNYgdypt 461
Cdd:cd10333  386 LDFWVGTILLVILGLIEIIVFGWIFGAKKGW-EEINRGALIKVPRFYKYVMKYITPAFLAVVLVFWTISYIPKGY----- 459
                        490       500
                 ....*....|....*....|...
gi 446372232 462 EFVITYGWSIAAAFLIVALIISL 484
Cdd:cd10333  460 FKMNLIPTVWIARFVIIGLFLFL 482
SLC6sbd_SERT-like cd11497
Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; ...
4-484 1.71e-70

Na(+)- and Cl(-)-dependent monoamine transporters, SERT, NET, DAT1 and related proteins; solute binding domain; This subgroup represents the solute-binding domain of transmembrane transporters that transport monoamine neurotransmitters from synaptic spaces into presynaptic neurons. Members include: NET which transports norepinephrine, SERT which transports serotonin, and DAT1 which transports dopamine. These transporters may play a role in diseases including depression, anxiety disorders, attention-deficit hyperactivity disorder, and in the control of human behavior and emotional states. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271388  Cd Length: 537  Bit Score: 234.13  E-value: 1.71e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:cd11497    1 RETWGKKIDFLLSVIGFAVDLGNVWRFPYLCYKNGGGAFLIPYLIMLIFGGLPLFYMELALGQFNRSGCITVWKKICPLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAIT---------GAWGKD----------------------TQSFLFKEY 132
Cdd:cd11497   81 KGVGYAICIIAFYVAFYYNVIIAWALYYLFSSFTselpwtscnNPWNTPnctdvsnrnnsssingtgltspAEEYFERKV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 133 LHV--ADKPGQFGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVnRIFIPLLVVMFLIIVVRAVTMEGAMQGLDAFFKP 210
Cdd:cd11497  161 LELqkSEGIDDLGPIKWQLALCLFAVFIIVYFSLWKGVKSSGKVV-WVTATMPYVVLSILLIRGLTLPGASDGIKYYLTP 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 211 DWSRIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVPVD 290
Cdd:cd11497  240 DFSKLKDPEVWIDAATQIFFSLGPGFGVLLALSSYNKFHNNCYRDALVTSSINCATSFFSGFVIFSVLGYMAHKQNVPIE 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 291 KVASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKF---SLSREKTIGIMGTLLVLVS 367
Cdd:cd11497  320 DVATEGPGLVFIVYPEAIATLPGSTFWAIIFFLMLITLGLDSTFGGLEAVITGLCDEFpflSRRRELFVLGLVIICFLLA 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 368 LVFATRGGLMFLDVVDYFANNFGLITIALAEVVTIGLI--LRRlpvyqnhanFVSDIKL------GTFWRVSLLVITPLM 439
Cdd:cd11497  400 LPTVTYGGIYVVTLLDRYAAGISILFIVFFEAVAVSWFygVDR---------FSDDIEEmlgfrpGLYWRVCWKFISPIF 470
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*
gi 446372232 440 LGYMLIDGTIQNIKKNYGDYptefvITYGWSIAAAFLIVALIISL 484
Cdd:cd11497  471 LLFIVIFSLVSYEPLQYQDY-----VYPPWANVVGWVIACSSIVL 510
SLC6sbd_GlyT2 cd11499
Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain; GlyT2 (also ...
4-479 4.62e-70

Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain; GlyT2 (also called NET1) is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT2 is encoded by the SLC6A5 gene. GlyT2 is expressed in brain and spinal cord. GlyT2 may play a role in pain, and in spasticity. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271389  Cd Length: 597  Bit Score: 234.51  E-value: 4.62e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGhRHRGSAPLTFFRISPRA 83
Cdd:cd11499    1 RGNWSNKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLIMLALAGLPIFLLEVSLG-QFASQGPVSVWKAIPAL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTY--FAITGAWG-----------KDTQSFLF--------------------- 129
Cdd:cd11499   80 QGCGIAMLIISVLIAIYYNIIMCYTLFYLFasLVEVLPWAscnnpwntpecKDKDMLLLdsciisdrpiiqiknstfcmt 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 130 ----------------------KEY-----LHVA---DKPGqfgglvpEVLIPLA----LVWIIVLGVAFKGVKKGIEVV 175
Cdd:cd11499  160 aypnvtmvnftsvdnktfvsgsEEYfkynvLKISagiEYPG-------EIRWPLAaclfLAWLIVYASLAKGIKTSGKVV 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 176 NRIFIPLLVVMfLIIVVRAVTMEGAMQGLDAFFKPDWSRIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNN 255
Cdd:cd11499  233 YFTATFPYVVL-VILLIRGVTLPGAGSGIWYFITPKWEKLNDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRD 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 256 AFITGFANSGFELLAGIGVFAALGFMANNMGVPVDKVASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLIS 335
Cdd:cd11499  312 TLIVTCTNSATSIFAGFVIFSVIGFMAHELKVPIESVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFA 391
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 336 LAEVCFAAVSEKFS--LSREKTIGIMGTLLVLVSLVFA--TRGGLMFLDVVDYFANNFGLITIALAEVVTIGLI--LRRl 409
Cdd:cd11499  392 TIETIVTSVSDEFPkyLRTHKPQFTLVCCLSFFIMGFPmiTQGGIYMLQLVDTYAASYSLVIIAIFELVGISYIygLQR- 470
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446372232 410 pvyqnhanFVSDIKL------GTFWRVSLLVITPLMLGYMLIDGTIQNIKKNYGDYptefviTY-GWSIAAAFLIVA 479
Cdd:cd11499  471 --------FCEDIEMmigfqpNKFWKVCWAFVTPTILTFILAFSFYQWEPMTYGSY------TYpNWSMVLGWLMLA 533
SLC6sbd_SERT-like_u1 cd11556
uncharacterized subgroup of the SERT-like Na(+)- and Cl(-)-dependent monoamine transporter ...
4-459 7.85e-67

uncharacterized subgroup of the SERT-like Na(+)- and Cl(-)-dependent monoamine transporter subfamily; solute binding domain; SERT-like Na(+)- and Cl(-)-dependent monoamine transporters, transport monoamine neurotransmitters from synaptic spaces into presynaptic neurons. Members include: the norepinephrine transporter NET, the serotonin transporter SERT , and the dopamine transporter DAT1. These latter may play a role in diseases or disorders including depression, anxiety disorders, and attention-deficit hyperactivity disorder, and in the control of human behavior and emotional states. They belongs to the solute carrier 6 (SLC6) transporter family. Members of this subgroup are uncharacterized.


Pssm-ID: 271405  Cd Length: 552  Bit Score: 225.04  E-value: 7.85e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:cd11556    1 RETWSKKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYGIMLVVGGIPLFYMELALGQYNRKGAITSWGRLCPLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAITGA-------------------WGKDTQSFL---------------- 128
Cdd:cd11556   81 KGIGYAVVLIAFYVDFFYNVIIAWSLYYFFASFTFNlpwtscnnswntpncrefhWSEDGTVPCrsanqsfsaenqsaqs 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 129 ------FKEY-------LHVADKPGQFGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVnrIFIPLL-VVMFLIIVVRA 194
Cdd:cd11556  161 enftsaASEYfergvleLNRSEGVHDLGNIRWDIALCLFAVYLICYFSLWKGIHTSGKVV--WFTALFpYVVLFILLIRG 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 195 VTMEGAMQGLDAFFKPDWSRIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGV 274
Cdd:cd11556  239 VTLPGSFNGIQYYLTPNFEALKKAEVWVDAATQVFFSLGPGFGVLLAYASYNKFHNNVYKDALLTSFINCATSFLSGFVI 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 275 FAALGFMANNMGVPVDKVASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKFSL---S 351
Cdd:cd11556  319 FSVLGYMAHRSGVPIEDVATEGPGLVFVVYPEALSTMPGSTFWSLIFFMMLMTLGLDSSFGGSEAIITALSDEFPIikrH 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 352 REKTIGIMGTLLVLVSLVFATRGGLMFLDVVDYFANNFGLITIALAEVVTIGLI--LRRlpvyqnhanFVSDIKL----- 424
Cdd:cd11556  399 RELFVGCLFSFYFVIGLASCTQGGFYFFHLLDRYAAGYSILIAVLFEAIAVSWIygTDR---------FCQDIKEmlgfp 469
                        490       500       510
                 ....*....|....*....|....*....|....*.
gi 446372232 425 -GTFWRVSLLVITPLMLGYMLIDGTIQNIKKNYGDY 459
Cdd:cd11556  470 pGIYWKVCWKFIAPIFLLFIITYGLIGYQPLTYDDY 505
SLC6sbd_GAT2 cd11507
Na(+)- and Cl(-)-dependent GABA transporter 2; solute-binding domain; This family includes ...
4-414 8.78e-67

Na(+)- and Cl(-)-dependent GABA transporter 2; solute-binding domain; This family includes human GAT2 (hGAT2) which transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. hGAT2 is encoded by the SLC6A13 gene, and is similar to mouse GAT-3, and rat GAT2. hGAT2 is expressed in brain, kidney, lung, and testis. hGAT2 is a potential drug target for treatment of epilepsy. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271396  Cd Length: 544  Bit Score: 224.86  E-value: 8.78e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:cd11507    1 RGQWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTSQGGVTAWRKICPLF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTY--FAITGAWGKDTQS-----------------------------FLFKEY 132
Cdd:cd11507   81 EGIGYASQVIVMLLNCYYIIVLAWALFYLFssFTIDLPWGSCGHEwntencmefqkanstlnvtsenatspvieFWERRV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 133 LHVADKPGQFGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVN-RIFIPLLvvMFLIIVVRAVTMEGAMQGLDAFFKPD 211
Cdd:cd11507  161 LKISDGIQHLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYfTATFPYL--MLVVLLIRGVSLPGALQGIQFYLYPD 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 212 WSRIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVPVDK 291
Cdd:cd11507  239 LSRLQDPQVWMDAGTQIFFSYAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMAEEQGVPISE 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 292 VASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKFSL------SREKTIGIMGTLLVL 365
Cdd:cd11507  319 VAESGPGLAFIAYPRAVVMLPFSPLWACFFFFMVVLLGLDSQFVCVESLVTALVDMYPTifrkknRRELLILAVSIVSFL 398
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 446372232 366 VSLVFATRGGLMFLDVVDYF-ANNFGLITIALAEVVTIGLILRRLPVYQN 414
Cdd:cd11507  399 VGLIMLTEGGMYVFQLFDYYaASGMCLLFVAIFETLCVAWVYGADRFYDN 448
SLC6sbd_GlyT1 cd11498
Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a ...
4-477 8.56e-66

Na(+)- and Cl(-)-dependent glycine transporter GlyT1; solute-binding domain; GlyT1 is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT1 is encoded by the SLC6A9 gene. GlyT1 is expressed in brain, pancreas, uterus, stomach, spleen, liver, and retina. GlyT1 may play a role in schizophrenia. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212067  Cd Length: 585  Bit Score: 222.87  E-value: 8.56e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGhRHRGSAPLTFFRISPRA 83
Cdd:cd11498   17 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFG-QFASQGCLGVWRVSPMF 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAIT---------GAWGKDTQSFLF------------------------- 129
Cdd:cd11498   96 KGVGYGMMVVSTYIGIYYNVVICIAFYYFFMSMTrvlpwtycnNPWNTPDCAGVLstnrsnatfanmsavvsnltellnr 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 130 --------KEY-----LHVADKPGQFGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVnRIFIPLLVVMFLIIVVRAVT 196
Cdd:cd11498  176 tlkrtspsEEYwrryvLNISDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVV-YFTATFPYVVLTILFIRGIT 254
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 197 MEGAMQGLDAFFKPDWSRIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFA 276
Cdd:cd11498  255 LEGAISGIMYYLTPQWDKILDAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSIIISITNCATSVYAGFVIFS 334
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 277 ALGFMANNMGVPVDKVASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKFS---LSRE 353
Cdd:cd11498  335 ILGFMANHLGVDVSEVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAVVDEIGndwIIRN 414
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 354 KTIGIMGTLLV--LVSLVFATRGGLMFLDVVDYFANNFGLITIALAEVVTIGLILrrlpvyqNHANFVSDIKL------G 425
Cdd:cd11498  415 KTYVTLGVAIIgfLLGIPLTTQAGIYWLLLMDNYAASFSLVIISCIMCIAIMYIY-------GHRNYFKDIEMmlgfppP 487
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446372232 426 TFWRVSLLVITPLMLGYMLIDGTIQNIKKNYGDYptefvITYGWSIAAAFLI 477
Cdd:cd11498  488 LFFQICWRFVSPAIIFFILIFTVIQYRPITYNDY-----VYPGWAIVIGFLM 534
SLC6sbd_BGT1 cd11511
Na(+)- and Cl(-)-dependent betaine/GABA transporter-1, and related proteins; solute-binding ...
4-437 1.68e-65

Na(+)- and Cl(-)-dependent betaine/GABA transporter-1, and related proteins; solute-binding domain; BGT1 is a relatively low-affinity transporter of gamma-aminobutyric acid (GABA), and can also transport betaine. GABA is the main inhibitory neurotransmitter within the mammalian CNS. Human BGT1 is encoded by the SLC6A12 gene, and is similar to mouse GAT2. Mouse GAT2 plays a role in transporting GABA across the blood-brain barrier. In addition to being expressed in cells of the central nervous system, BGT1 is expressed in peripheral tissues, including kidney, liver, and heart. An association has been shown between the SLC6A12 gene and the occurrence of aspirin-intolerant asthma, and BGT1 is a drug target for antiepileptic drugs. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212080  Cd Length: 541  Bit Score: 221.34  E-value: 1.68e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:cd11511    2 RGQWRNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYLIFLFTCGIPLFFLETALGQYTSQGGVTAWRKICPIF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAITGA---------WGKD-----------------------TQSFLFKE 131
Cdd:cd11511   82 EGIGYASQVIESYLNVYYIIILSWALFYLFSSFTSVlpwatcnnpWNSDlcvdflnhsgadnrtppenatspVMEFWEKR 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 132 YLHVADKPGQFGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVnRIFIPLLVVMFLIIVVRAVTMEGAMQGLDAFFKPD 211
Cdd:cd11511  162 VLGLTDGIHKLGTVRWELALCLLLAWIICYFCIWKGVKSTGKVV-YFTATFPYLMLVILLVRGVTLPGAAEGIIFYLKPD 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 212 WSRIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVPVDK 291
Cdd:cd11511  241 LSRLADPQVWMDAGTQILFSYAICQGCLTALGSYNKYTNNCYRDCIMLCFLNSATSFVAGFAIFSVLGFMAREQGVPISE 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 292 VASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKF------SLSREKTIGIMGTLLVL 365
Cdd:cd11511  321 VAESGPGLAFIAYPTAVTMMPVSQLWSCLFFLMLIFLGLDSQFVCVESMVTASIDMFpgvfrkKGRRELLILAIAVICYL 400
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446372232 366 VSLVFATRGGLMFLDVVDYFA-NNFGLITIALAEVVTIGLILRRLPVYQNHANFVSdIKLGTFWRVSLLVITP 437
Cdd:cd11511  401 LGLLLVTEGGMYIFQLFDYYAaSGTCLLFLAIFEVICIGWVYGANRFYDNIEDMIG-YRPWPLIKICWLVFTP 472
SLC6sbd_GAT1 cd11506
Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain; GAT1 transports ...
4-459 1.31e-64

Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain; GAT1 transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. Human GAT1 is encoded by the SLC6A1 gene. GAT1 is expressed in brain and peripheral nervous system. The antiepileptic drug, Tiagabine, inhibits GAT1. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212075 [Multi-domain]  Cd Length: 598  Bit Score: 220.23  E-value: 1.31e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGhRHRGSAPLTFFRISPRA 83
Cdd:cd11506   43 RDTWKGKFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLG-QYTSIGGLGVWKLAPMF 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAIT---------GAWGKD--------------TQSFL--FKEYLHVA-- 136
Cdd:cd11506  122 KGVGLAAAVLSFWLNIYYIVIIAWAIYYLYNSFTttlpwkscdNPWNTDrcfsnysmanttnmTSAVVefWERNMHQMtd 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 137 --DKPGQfggLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVnRIFIPLLVVMFLIIVVRAVTMEGAMQGLDAFFKPDWSR 214
Cdd:cd11506  202 glEKPGQ---IRWPLAITLAIAWVLVYFCIWKGVGWTGKVV-YFSATYPYIMLFILFFRGVTLPGAKEGILFYITPNFSK 277
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 215 IFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVPVDKVAS 294
Cdd:cd11506  278 LSDSEVWLDAATQIFFSYGLGLGSLIALGSYNPFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRPIADVAA 357
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 295 AGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKFSL----SREKTIGIMGTLLVLVSLVF 370
Cdd:cd11506  358 SGPGLAFLAYPEAVTQLPISPLWAVLFFSMLLMLGIDSQFCTVEGFITALVDEFPRllrnRREIFIAVVCIVSYLIGLSN 437
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 371 ATRGGLMFLDVVDYF-ANNFGLITIALAEVVTIGLILRRLPVYQNHANFVSdIKLGTFWRVSLLVITPLMLGYMLIDGTI 449
Cdd:cd11506  438 ITQGGIYVFKLFDYYsASGMSLLFLVFFECVSISWFYGVNRFYDNIEEMVG-YRPCIWWKLCWSFFTPIIVAGVFLFSAV 516
                        490
                 ....*....|
gi 446372232 450 QNIKKNYGDY 459
Cdd:cd11506  517 QMTPLTMGNY 526
SLC6sbd_SERT cd11513
Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain; SERT (also ...
4-486 3.12e-62

Na(+)- and Cl(-)-dependent serotonin transporter SERT; solute-binding domain; SERT (also called 5-HTT), is a transmembrane transporter that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The antiport of a K+ ion is believed to follow the transport of serotonin and promote the reorientation of SERT for another transport cycle. Human SERT is encoded by the SLC6A4 gene. SERT is expressed in brain, peripheral nervous system, placenta, epithelium, and platelets. SERT may play a role in diseases or disorders including anxiety, depression, autism, gastrointestinal disorders, premature ejaculation, and obesity. It may also have a role in social cognition. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271399  Cd Length: 537  Bit Score: 212.38  E-value: 3.12e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:cd11513    1 RETWGKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLIPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAITG-------------------------AWGKDTQS----FLFKEYLH 134
Cdd:cd11513   81 KGIGYAICIIALYVASYYNTIIAWALYYLYSSFTDelpwtscnnswntgnctnyfakdniTWTLHSTSpaeeFYTRHVLQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 135 VADKPG--QFGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVnRIFIPLLVVMFLIIVVRAVTMEGAMQGLDAFFKPDW 212
Cdd:cd11513  161 VHRSKGlgDLGGISWQLTLCLFLIFTIVYFSIWKGVKTSGKVV-WVTATFPYIVLFILLVRGATLPGAWRGVVFYLKPNW 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 213 SRIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVPVDKV 292
Cdd:cd11513  240 QKLLETGVWVDAAAQIFFSLGPGFGVLLALASYNKFNNNCYQDALVTSVVNCLTSFVSGFVIFTVLGYMAEMRNEDVSEV 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 293 A-SAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKF--SLSREKTIGIMGTLLV--LVS 367
Cdd:cd11513  320 AkDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFphVWSKRREKFVLGLVIVcfLGS 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 368 LVFATRGGLMFLDVVDYFANNFGLITIALAEVVTIGLilrrlpvYQNHANFVSDIKL------GTFWRVSLLVITPLMLG 441
Cdd:cd11513  400 LATLTFGGAYVVKLLEEYATGPAVLTVVLLEAVAVSW-------FYGITQFCNDVKEmlgfspGWFWRVCWVAISPLFLL 472
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*.
gi 446372232 442 YMLIDGTIQNIKKNYGDYP-TEFVITYGWSIAAAFLIVALIISLKK 486
Cdd:cd11513  473 FIICSFLMNPPQLRLFDYNyPYWSIVVGYCIGTSSIICIPIYMAYR 518
SLC6sbd_DAT1 cd11514
Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called ...
4-489 9.44e-61

Na(+)- and Cl(-)-dependent dopamine transporter 1; solute-binding domain; DAT1 (also called DAT), is a plasma membrane transport protein that functions at the dopaminergic synapses to transport dopamine from the extracellular space back into the presynaptic nerve terminal. Human DAT1 is encoded by the SLC6A3 gene, and is expressed in the brain. DAT1 may play a role in diseases or disorders related to dopaminergic neurons, including attention-deficit hyperactivity disorder (ADHD), Tourette syndrome, Parkinson's disease, alcoholism, drug abuse, schizophrenia, extraversion, and risky behavior. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212083  Cd Length: 555  Bit Score: 209.02  E-value: 9.44e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPlTFFRISPRA 83
Cdd:cd11514    1 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLFFMVIAGMPLFYMELALGQFNREGAA-GVWKICPIF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAITG---------AWGK-------------------DT------QSFLF 129
Cdd:cd11514   80 KGVGFTVILISLYVGFFYNVIIAWALFYLFSSFTGelpwihcnnSWNSpncsdahpgdssgdssglnDTykttpaAEYFE 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 130 KEYLHVADKPG--QFGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVnRIFIPLLVVMFLIIVVRAVTMEGAMQGLDAF 207
Cdd:cd11514  160 RGVLHLHESHGihDLGPPRWQLTSCLVVVIVLLYFSLWKGVKTSGKVV-WITATMPYVVLTALLLRGVTLPGAIDGIKAY 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 208 FKPDWSRIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGV 287
Cdd:cd11514  239 LSVDFLRLCEASVWIDAATQICFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFFSGFVVFSFLGYMAQKHNV 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 288 PVDKVASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKFSL---SREKTIGIMGTLLV 364
Cdd:cd11514  319 PIGDVAKDGPGLIFIIYPEAIATLPLSSVWAVIFFIMLLTLGIDSAMGGMESVITGLIDEFKFlhrHRELFTLFIVLSTF 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 365 LVSLVFATRGGLMFLDVVDYFANNFGLITIALAEVVTIGLilrrlpvYQNHANFVSDI------KLGTFWRVSLLVITPL 438
Cdd:cd11514  399 LISLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGIAW-------FYGVGRFSDDIeemigqRPGLYWRLCWKFVSPC 471
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446372232 439 MLGYMLIDGTIQNIKKNYGDYP-TEFVITYGWSIAAAFLIVALIISLKKWNA 489
Cdd:cd11514  472 FLLFVVVVSIVTFRPPKYGSYIfPDWANMVGWCLAISSMAMVPLYAIYKFCS 523
SLC6sbd_NET cd11512
Na(+)- and Cl(-)-dependent norepinephrine transporter NET; solute-binding domain; NET (also ...
4-487 6.92e-60

Na(+)- and Cl(-)-dependent norepinephrine transporter NET; solute-binding domain; NET (also called NAT1, NET1), is a transmembrane transporter that transports the neurotransmitter norepinephrine from synaptic spaces into presynaptic neurons. Human NET is encoded by the SLC6A2 gene. NET is expressed in brain, peripheral nervous system, adrenal gland, and placenta. NET may play a role in diseases or disorders including depression, orthostatic intolerance, anorexia nervosa, cardiovascular diseases, alcoholism, and attention-deficit hyperactivity disorder. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212081  Cd Length: 560  Bit Score: 206.74  E-value: 6.92e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPlTFFRISPRA 83
Cdd:cd11512    1 RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAA-TVWKICPCF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAIT---------GAW----------------GKDTQ----------SFL 128
Cdd:cd11512   80 KGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTselpwttcgNVWnspnctdpkllnasvlGNGTKyskykltpaaEFY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 129 FKEYLHVADKPGQFGGLVP--EVLIPLALVWIIVLGVAFKGVKKGIEVVnRIFIPLLVVMFLIIVVRAVTMEGAMQGLDA 206
Cdd:cd11512  160 ERGVLHLHESAGIHDLGLPrwQLTLCLFVVVIVLFFSLWKGVKTSGKVV-WITATLPYVVLFVLLIHGVTLPGAFNGINA 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 207 FFKPDWSRIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMG 286
Cdd:cd11512  239 YLHIDFKRLKEATVWIDAATQIFYSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHK 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 287 VPVDKVASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKFS-LSREKTIGIMGTLLV- 364
Cdd:cd11512  319 VKIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFIMLLTLGIDSSMGGMEAVITGLADDFSiLKKHRKLFTFGVAFIt 398
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 365 -LVSLVFATRGGLMFLDVVDYFANNFGLITIALAEVVTIGLILrRLPVYQNHANFVSDIKLGTFWRVSLLVITPLMLGYM 443
Cdd:cd11512  399 fLLALFCITNGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFY-GVDRFSDDIQQMMGFRPGLYWRLCWKFVSPAFLLFV 477
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*
gi 446372232 444 LIDGTIQNIKKNYGDYPTEFVITY-GWSIAAAFLIVALIISLKKW 487
Cdd:cd11512  478 VIVSIINFKPLTYDDYNFPPWANRtGWGIALSSMLLVPIYVIYKF 522
SLC6sbd_NTT4-like cd11515
Na(+)-dependent neurotransmitter transporter 4, and related proteins; solute-binding domain; ...
4-450 2.85e-58

Na(+)-dependent neurotransmitter transporter 4, and related proteins; solute-binding domain; This subgroup includes the solute-binding domain of NTT4 (also called XT1) and SBAT1 (also called B0AT2, v7-3, NTT7-3); both these proteins can transport neutral amino acids. Human SBAT1 is encoded by the SLC6A15 gene, a susceptibility gene for major depression. SBAT1 is expressed in brain, and may have a role in transporting neurotransmitter precursors into neurons. Human NTT4 is encoded by the SLC6A17 gene. NTT4 is specifically expressed in the nervous system, in synaptic vesicles of glutamatergic and GABAergic neurons, and may play an important role in synaptic transmission. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271400 [Multi-domain]  Cd Length: 530  Bit Score: 201.71  E-value: 2.85e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:cd11515    1 RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLIVIGIPLFFLELSVGQRIRRGSIGVWNYISPRL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTY--FAITGAWGK--------------------DTQSFLFKEYLHVADKPGQ 141
Cdd:cd11515   81 GGIGFASCVVCLFVALYYNVIIGWSLFYFSqsFQQPLPWDQcplvknashtfvepecekssATTYYWYREALNISDSISE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 142 FGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVV--NRIFIPLLVVMFLIivvRAVTMEGAMQGLDAFFKPDWSRIFDGK 219
Cdd:cd11515  161 SGGLNWKMTICLLAAWVIVCLAMIKGIQSSGKIMyfSSLFPYVVLICFLI---RALLLNGSVDGIRHMFTPKLEIMLEPK 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 220 VWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMAnnMGVPVDKV------- 292
Cdd:cd11515  238 VWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKI--QKVKEEEFpalhlnp 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 293 ---------ASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKFSLSREKTIGIMGTLL 363
Cdd:cd11515  316 cliedelnkAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIEGITTPIVDTFKVRKEILTVICCLLA 395
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 364 VLVSLVFATRGGLMFLDVVDYFANNFGLITIALAEVVTIGLILrrlpvyqNHANFVSDIK--LG----TFWRVSLLVITP 437
Cdd:cd11515  396 FCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVAFVY-------GIDKFMEDLKdmLGfrpyRYYYYMWKYISP 468
                        490
                 ....*....|...
gi 446372232 438 LMLGYMLIDGTIQ 450
Cdd:cd11515  469 LMLLSLLIASIVN 481
SLC6sbd_ATB0 cd11501
Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain; ATB0+ (also ...
4-486 9.25e-58

Na(+)- and Cl(-)-dependent beta-alanine transporter ATB0+; solute-binding domain; ATB0+ (also known as the beta-alanine carrier) is a transmembrane transporter with a broad substrate specificity; it can transport non-alpha-amino acids such as beta-alanine with low affinity, and can transport dipolar and cationic amino acids such as leucine and lysine, with a higher affinity. It may have a role in the absorption of essential nutrients and drugs in the distal regions of the human gastrointestinal tract. Human ATB0+ is encoded by the SLC6A14 gene. ATB0+ is expressed in the lung, trachea, salivary gland, mammary gland, stomach, and pituitary gland. ATB0+ may play a role in obesity, and its upregulation may have a pathogenic role in colorectal cancer. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271391  Cd Length: 602  Bit Score: 201.65  E-value: 9.25e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGhRHRGSAPLTFFRISPRA 83
Cdd:cd11501    1 RGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYKNGGGAFLIPYTIMLALAGLPLFFMECSLG-QFASLGPISVWRILPLF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTY--------FAITGAWGKDTQS---------------FLFKEYLHVAD--- 137
Cdd:cd11501   80 QGVGITMVLISTFVAIYYNVIIAYSLYYLFasfqselpWSDCFSWADENCSktpivthcnvstannGIHENKSWVDInnl 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 138 ---------KPGQF--------------------GGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVnrIFIPLL-VVMF 187
Cdd:cd11501  160 tcingsiiyQPGQLpseqywnkvalqrssgmdetGVIVWYLALCLLLSWIIVGAALFKGIKSSGKVV--YFTALFpYVVL 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 188 LIIVVRAVTMEGAMQGLDAFF--KPDWSRIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSG 265
Cdd:cd11501  238 LILLVRGATLEGASDGIEYYIgaQSNITKLMEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFHNNCYSDAIVVCVTNCL 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 266 FELLAGIGVFAALGFMANNMGVPVDKVASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVS 345
Cdd:cd11501  318 TSVFAGFAIFSVLGHMAHVSGRPVSEVVDSGFDLAFIAYPEALSKLPISPLWSILFFFMLLTLGLDSQFASIETITTTIQ 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 346 EKFSLSREKTIGIMGT----LLVLVSLVFATRGGLMFLDVVDYFANNFGLITIALAEVVTIGLILrrlpvyqNHANFVSD 421
Cdd:cd11501  398 DAYPKVMKKMRIPITLgvcvILFLLGLVCVTQAGIYWVNLIDHFCAGWGILFAAVLELVGIIWIY-------GGNRFIED 470
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446372232 422 IKL--GT-------FWRVSLLVITPLMLGYMLIDGTIQNIKKNYGD--YPTeFVITYGWSIAAAFLIVALIISLKK 486
Cdd:cd11501  471 IEMmiGAkswifwlWWRACWFFITPVLLIAILIWSLVTFHSPTYGSvpYPD-WGTALGWCMIIFCLIWIPIVAVIK 545
SLC6sbd_GAT3 cd11508
Na(+)- and Cl(-)-dependent GABA transporter 3; solute-binding domain; This family includes ...
4-490 1.32e-57

Na(+)- and Cl(-)-dependent GABA transporter 3; solute-binding domain; This family includes human GAT3 (hGAT3) a high-affinity transporter of gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. hGAT3 is encoded by the SLC6A11 gene, and is similar to mouse GAT4, and rat GAT3/GATB. GAT3 is expressed primarily in the glia of the brain, and is a potential drug target for antiepileptic drugs. This subgroup belongs to the solute carrier 6 (SLC6) transporter family


Pssm-ID: 212077  Cd Length: 542  Bit Score: 200.21  E-value: 1.32e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:cd11508    2 RGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTYFAITGA---------WGKDT----QSFLFKEYLHVA-------------- 136
Cdd:cd11508   82 EGIGYATQVIEAHLNVYYIIILAWAIFYLFNCFTTElpwatcgheWNTENcvefQKLNSSNCSHVSlqnatspvmefwer 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 137 ------DKPGQFGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVnRIFIPLLVVMFLIIVVRAVTMEGAMQGLDAFFKP 210
Cdd:cd11508  162 rvlaisDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVV-YVTATFPYIMLLILLIRGVTLPGASEGIKFYLYP 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 211 DWSRIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVPVD 290
Cdd:cd11508  241 DLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIA 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 291 KVASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKF------SLSREKTIGIMGTLLV 364
Cdd:cd11508  321 EVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYpkvfrrGYRRELLILALSIVSY 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 365 LVSLVFATRGGLMFLDVVD-YFANNFGLITIALAEVVTIGLILRRLPVYQNHANFVSdIKLGTFWRVSLLVITPLMLGYM 443
Cdd:cd11508  401 FLGLVMLTEGGMYIFQLFDsYAASGMCLLFVAIFECICIGWVYGSNRFYDNIEDMIG-YRPLSLIKWCWMVITPGICAGI 479
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446372232 444 LIDGTIQNIKKNYGD---YPtEFVITYGWSIA-AAFLIVALIISLKKWNAQ 490
Cdd:cd11508  480 FIFFLVKYKPLKYNNvytYP-DWGYGIGWLMAlSSMICIPLWICIKMWKTE 529
SLC6sbd_B0AT3 cd11517
glycine transporter, B0AT3; solute-binding domain; B0AT3 (also called Xtrp2, XT2) transports ...
4-440 3.34e-56

glycine transporter, B0AT3; solute-binding domain; B0AT3 (also called Xtrp2, XT2) transports glycine. Human B0AT3 is encoded by the SLC6A18 gene. B0AT3 is expressed in the kidney. Mutations in the SLC6A18 gene may contribute to the autosomal recessive disorder iminoglycinuria and its related disorder hyperglycinuria. SLC6A18 or its neighboring genes are associated with increased susceptibility to myocardial infarction. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212086 [Multi-domain]  Cd Length: 576  Bit Score: 196.96  E-value: 3.34e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:cd11517    2 RPKWDNKAQYLLSCIGFAVGLGNIWRFPYLCQTYGGGAFLIPYFIALVFEGIPLFHLELAIGQRLRKGSIGVWTTISPYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTY--FAITGAWG------------KDTQS------FLFKEYLHVADKPGQFG 143
Cdd:cd11517   82 GGVGLGCVTVSFLVSLYYNTILAWVLWYFLnsFQHPLPWSscpldlnrtgfvEECQGstavsyFWYRQTLNITPDINDSG 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 144 GLVPEVLIPLALVWIIVLGVAFKGVKKGIEV--VNRIFIPLLVVMFLIivvRAVTMEGAMQGLDAFFKPDWSRIFDGKVW 221
Cdd:cd11517  162 SIQWWLLLCLAACWAIVYLCVIRGIETTGKViyFTALFPYLVLTIFLI---RGLTLPGATEGLIYLFTPNMHILQNPRVW 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 222 LAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMA----------------NNM 285
Cdd:cd11517  239 LDAATQIFFSLSLAFGGHIAFASYNPPRNDCEKDAVTIALVNSMTSLYASIPVFSVLGFKAtndyehcldrnilsliNEF 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 286 GVP-------------------------------------VDKVASaGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVA 328
Cdd:cd11517  319 DFPeqsisrdnypsvlmhlnatwpervaqlplkaclledfLDKSAS-GPGLAFIVFTEAVLHMPGAQVWAVLFFGMLFTL 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 329 GITSLISLAEVCFAAVSEKFSLSR----EKTIGIMGTLLVLVSLVFATRGGLMFLDVVDYFANNFGLITIALAEVVTIGL 404
Cdd:cd11517  398 GLSSMFGNVEGVITPLLDVGVLPRwvpkEALTGLVCLVCFLSALCFTLQSGNYWLEIFDSFAASLNLLVIAFFEVVGVVY 477
                        490       500       510
                 ....*....|....*....|....*....|....*.
gi 446372232 405 ILrRLPVYQNHANFVSDIKLGTFWRVSLLVITPLML 440
Cdd:cd11517  478 VY-GIKRFCDDIEWMTGRRPSLYWRLTWRVVSPLLL 512
SLC6sbd_TauT cd11510
Na(+)- and Cl(-)-dependent taurine transporter; solute-binding domain; TauT is a Na(+)- and Cl ...
4-477 7.48e-56

Na(+)- and Cl(-)-dependent taurine transporter; solute-binding domain; TauT is a Na(+)- and Cl(-)-dependent, high-affinity, low-capacity transporter of taurine and beta-alanine. Human TauT is encoded by the SLC6A6 gene. TauT is expressed in brain, retina, liver, kidney, heart, spleen, and pancreas. It may play a part in the supply of taurine to the intestinal epithelium and in the between-meal-capture of taurine. It may also participate in re-absorbing taurine that has been deconjugated from bile acids in the distal lumen. Functional TauT protects kidney cells from nephrotoxicity caused by the chemotherapeutic agent cisplatin; cisplatin down-regulates TauT in a p53-dependent manner. In mice, TauT has been shown to be important for the maintenance of skeletal muscle function and total exercise capacity. TauT-/- mice develop additional clinically important diseases, some of which are characterized by apoptosis, including vision loss, olfactory dysfunction, and chronic liver disease. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271398  Cd Length: 542  Bit Score: 195.46  E-value: 7.48e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:cd11510    1 REKWASKIDFLLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFFLEVALGQYTSEGGITCWEKLCPIF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTY--FAITGAWGKDTQS--------------------------------FLF 129
Cdd:cd11510   81 TGIGYASIVIVSLLNIYYIVILAWALYYLFqsFQSELPWAHCNQKwntpccvedtlrknktlwasinatnftspvteFWE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 130 KEYLHVADKPGQFGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVnRIFIPLLVVMFLIIVVRAVTMEGAMQGLDAFFK 209
Cdd:cd11510  161 RNVLSLSAGIEHVGTIKWDLALCLLLVWVVCFFCIWKGVKSTGKVV-YFTATFPFLMLIVLLIRGVTLPGAAEGIKFYLY 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 210 PDWSRIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVPV 289
Cdd:cd11510  240 PDITRLGDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNCYRDCLLLGCLNSGTSFVSGFAIFSVLGFMAQEQGVDI 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 290 DKVASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKF------SLSREKTIGIMGTLL 363
Cdd:cd11510  320 ADVAESGPGLAFIAYPKAVTMMPLPTFWAILFFIMLLLLGLDSQFVEVEGQITSLVDLYpsflrkGYRREIFIAIVCFIS 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 364 VLVSLVFATRGGLMFLDVVDYF-ANNFGLITIALAEVVTIGLILRRLPVYQNHANFVSdIKLGTFWRVSLLVITPLMLGY 442
Cdd:cd11510  400 YLLGLTMVTEGGMYVFQLFDYYaASGVCLLWVAFFECIAVAWVYGGDNMYDAIEDMIG-YRPGPWMKYSWIVITPVLCVG 478
                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 446372232 443 MLIDGTIQNIKKNYGD---YPtEFVITYGWSIAAAFLI 477
Cdd:cd11510  479 CFIFSLVKYEPLTYNKvyvYP-EWAIGLGWVLALSSMI 515
SLC6sbd_CT1 cd11509
Na(+)- and Cl(-)-dependent creatine transporter 1; solute-binding domain; CT1 (also called ...
4-402 1.60e-55

Na(+)- and Cl(-)-dependent creatine transporter 1; solute-binding domain; CT1 (also called CRTR, CRT) transports creatine. Human CT1 is encoded by the SLC6A8 gene. CT1 is ubiquitously expressed, with highest levels found in skeletal muscle and kidney. Creatine is absorbed from food or synthesized from arginine and plays an important role in energy metabolism. Deficiency in human CT1 leads to X-linked cerebral creatine transporter deficiency. In males, this disorder is characterized by language and speech delays, autistic-like behavior, seizures in about 50% of cases, and can also involve midfacial hypoplasia, and short stature. In females, it is characterized by mild cognitive impairment with behavior and learning problems. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271397  Cd Length: 589  Bit Score: 195.45  E-value: 1.60e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSApLTFFRISPRA 83
Cdd:cd11509    1 RETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYLLIAFVGGIPIFFLEIALGQFMKAGG-INAWNIAPLF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISY----------------------------------------TYFAITGAWGKD 123
Cdd:cd11509   80 KGLGYASMVIVFFCNTYYIMVLAWGFYYlvksftntlpwatcgnpwntpncteifrhadcnngassagSLANLTCDELAN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 124 TQS----FLFKEYLHVADKPGQFGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVnrIFIPLL-VVMFLIIVVRAVTME 198
Cdd:cd11509  160 RRSpvieFWERKVLRLSGGLEEPGALNWELTLCLLATWVLVYFCVWKGVKSTGKVV--YFTATFpYVVLVVLLVRGVTLP 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 199 GAMQGLDAFFKPDWSRIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAAL 278
Cdd:cd11509  238 GALDGIIYYLKPDWSKLGEAQVWIDAGTQIFFSYAIGLGALTALGSYNRFHNNCYKDAFILALINSGTSFFAGFVVFSIL 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 279 GFMANNMGVPVDKVASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAV------SEKFSLSR 352
Cdd:cd11509  318 GFMASEQGVDISKVAESGPGLAFIAYPKAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGIldllpaKYYFRYQR 397
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446372232 353 EKTIGIMGTLLVLVSLVFATRGGLMFLDVVDYF-ANNFGLITIALAEVVTI 402
Cdd:cd11509  398 EVVVALCCLLCFLIDLSMVTEGGMYVFQLFDYYsASGTTLLWQAFWECVVV 448
SLC6sbd_SIT1 cd11518
Na(+)- and Cl(-)-dependent imino acid transporter SIT1; solute-binding domain; SIT1 (also ...
2-445 2.99e-52

Na(+)- and Cl(-)-dependent imino acid transporter SIT1; solute-binding domain; SIT1 (also called XTRP3, XT3, IMINO) transports imino acids, such as proline, pipecolate, MeAIB, and sarcosine. It has weak affinity for neutral amino acids such as phenylalanine. Human SIT1 is encoded by the SLC6A20 gene. SIT1 is expressed in brain, kidney, small intestine, thymus, spleen, ovary, and lung. SLC6A20 is a candidate gene for the rare disorder iminoglycinuria. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271401 [Multi-domain]  Cd Length: 576  Bit Score: 186.32  E-value: 2.99e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   2 ETRQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISP 81
Cdd:cd11518    2 KTRPLWDNPLQFVFACISYAVGLGNVWRFPYLCQMYGGGGFLIPYLIMLILEGMPLLYLELAVGQLMRQGSIGAWKSISP 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  82 RAEFIGWWQMCVTFIVSTYYAVIIAWSISYTY--FAITGAW------------------GKDTQSFLFKEYLHVADKPGQ 141
Cdd:cd11518   82 YLGGVGVASVVVSFFLSMYYNVINAWAFWYLFhsFQDPLPWsncplnsnhtayneecekASPTQYFWYRKTLNISPSILE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 142 FGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVVN-RIFIPLLVVmfLIIVVRAVTMEGAMQGLDAFFKPDWSRIFDGKV 220
Cdd:cd11518  162 NGGIQWELAVCLILAWLVVYLCILRGTESTGKVVYvTALIPYLVL--LIYLIRGLTLHGAANGLAYMFTPKLEQLANPKT 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 221 WLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMA------------------ 282
Cdd:cd11518  240 WINAATQIFFSLGLGFGSLIAFASYNEPSNNCERHAIIVSLINSGTSIFASIVTFSIYGFKAtfnyencmkkvillltnt 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 283 ----------NNMG-----------------VPVDK---------VASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLT 326
Cdd:cd11518  320 fdleegsvttENLGdmknylasafpqeyssiVPQIKncslekeldTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFLMLL 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 327 VAGITSLI-SLAEVCFAAVSEKF---SLSREKTIGIMGTLLVLVSLVFATRGGLMFLDVVDYFANNFGLITIALAEVVTI 402
Cdd:cd11518  400 MLGIGSMLgNTAAILTPLTDSKFissHLPKEAISGLLCFTNCIIGLVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAV 479
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*
gi 446372232 403 GLI--LRRlpvYQNHANFVSDIKLGTFWRVSLLVITPLMLGYMLI 445
Cdd:cd11518  480 CYVygLRR---FENDLEAMTGHKLSWYWKIMWAFVSPLLIVSLFI 521
SLC6sbd_B0AT1 cd11516
Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain; B0AT1 (also ...
4-484 1.17e-51

Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain; B0AT1 (also called HND) transports neutral amino acids. Human B0AT1 is encoded by the SLC6A19 gene. B0AT1 is expressed primarily in the kidney and intestine; it requires collectrin for expression in the kidney, and angiotensin-converting enzyme 2 for expression in the intestine. Interaction with these two proteins implicates B0AT1 in more complex processes such as glomerular structure, exocytosis, and blood pressure control. The autosomal recessive disorder, Hartnup disorder, is caused by mutations in B0AT1. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212085 [Multi-domain]  Cd Length: 581  Bit Score: 184.71  E-value: 1.17e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:cd11516    1 RPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVFEGIPLLHLEFAIGQRLRKGSVGVWSTIHPTL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISY--------------------TYFAITGAWGKDTQSFLFKEYLHVADKPGQFG 143
Cdd:cd11516   81 KGVGIASMCVSFLVSLYYNTIIAWVMWYffnsfqeplpwsqcplnenrTGYIPECAKSSPVDYFWYRETLNTSTSIDDSG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 144 GLVPEVLIPLALVWiivlGVAFKGVKKGIEVVNR---IFIPLLVVMFLIIVVRAVTMEGAMQGLDAFFKPDWSRIFDGKV 220
Cdd:cd11516  161 GIQWWMVLCLACAW----GVLYVCTIRGIETTGKavyVTSTLPYLVLTIFLIRGLTLKGSVNGIKFLFTPDINELANPVT 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 221 WLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMAN----------------- 283
Cdd:cd11516  237 WLDAGAQVFYSFSLAFGGLISFSSYNSVHNNCEKDAVIISVINGFTSIYAATVIYSIIGFRATerfddcfdgniltlina 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 284 --------------------NMGVPvDKVAS----------------AGVGLAFVVFPQIINELPMSPLFGVLFFLSLTV 327
Cdd:cd11516  317 fdlpegnitqdnyqdmqqslNSTDP-DIISSlslqtcdlnnflsegvEGTGLAFIVFTEAITKMPLSPLWSVLFFIMLFC 395
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 328 AGITSLISLAEVCFAAVSE----KFSLSREKTIGIMGTLLVLVSLVFATRGGLMFLDVVDYFANNFGLITIALAEVVTIg 403
Cdd:cd11516  396 LGLSSMFGNMEGVLVPLQDlkviPKSWPKEIITGLICLVSFLIGLIFVLGSGNYWLALFDSFAGSIPLLIIAFCEMFSV- 474
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 404 LILRRLPVYQNHANFVSDIKLGTFWRVSLLVITPL-MLGYMLIDGTIQNIKK--------NYGDYPTEFVITYGWSIAAA 474
Cdd:cd11516  475 VYVYGIDRFNKDIEFMIGHKPNIFWQATWRVISPLiMLVIFLFYFVVKVSQElfysawdpEYEEFPKSQKISYPTWIYVI 554
                        570
                 ....*....|
gi 446372232 475 FLIVALIISL 484
Cdd:cd11516  555 IVILAGVPSL 564
SLC6sbd_SBAT1 cd11522
Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain; SBAT1 (also ...
4-450 9.85e-50

Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain; SBAT1 (also called B0AT2, v7-3, NTT7-3) is a high-affinity Na(+)-dependent transporter for large neutral amino acids, including leucine, isoleucine, valine, proline and methionine. Human SBAT1 is encoded by the SLC6A15 gene, a susceptibility gene for major depression. SBAT1 is expressed in brain, and may have a role in transporting neurotransmitter precursors into neurons. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212091 [Multi-domain]  Cd Length: 580  Bit Score: 179.73  E-value: 9.85e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:cd11522    1 RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLVPYLILLLVIGIPLFFLELSVGQRIRRGSIGVWNYISPKL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSI----------------------SYTYFAITGAWGKDTQSFLFKEYLHVADKPGQ 141
Cdd:cd11522   81 GGIGFASCIVCFFVALYYNVIIGWSLfyfsqsfqqplpwdqcplvknaSHTFVEPECEKSSATTYYWYREALNISSSISE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 142 FGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVV--NRIFIPLLVVMFLIivvRAVTMEGAMQGLDAFFKPDWSRIFDGK 219
Cdd:cd11522  161 SGGLNWKMTICLLAAWVMVCLAMIKGIQSSGKIMyfSSLFPYVVLICFLI---RALLLNGSVDGIRHMFTPKLEIMLEPK 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 220 VWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMG------------- 286
Cdd:cd11522  238 VWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANVINekciiqnsekiik 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 287 -----------VP-------------------VDKV---------------------ASAGVGLAFVVFPQIINELPMSP 315
Cdd:cd11522  318 llkmgnlsqdiIPhhinfssitaedynlvydiIQKVkeeefpalglkscqiedelnkAVQGTGLAFIAFTEAMTHFPASP 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 316 LFGVLFFLSLTVAGITSLISLAEVCFAAVSEKFSLSREKTIGIMGTLLVLVSLVFATRGGLMFLDVVDYFANNFGLITIA 395
Cdd:cd11522  398 FWSVMFFLMLVNLGLGSMFGTIEGIITPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVV 477
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446372232 396 LAEVVTIGLILrrlpvyqNHANFVSDIK--LG----TFWRVSLLVITPLMLGYMLIDGTIQ 450
Cdd:cd11522  478 ILENIAVSFVY-------GIDKFMEDLKdmLGftpnRYYYYMWKYISPLVLLSLLVASVVQ 531
SLC6sbd_NTT4 cd11521
Na(+)-dependent neurotransmitter transporter 4; solute-binding domain; NTT4 (also called XT1) ...
4-405 8.54e-49

Na(+)-dependent neurotransmitter transporter 4; solute-binding domain; NTT4 (also called XT1) transports the neutral amino acids, proline, glycine, leucine, and alanine, and may play an important role in synaptic transmission. Human NTT4 is encoded by the SLC6A17 gene. NTT4 is specifically expressed in the nervous system, in synaptic vesicles of glutamatergic and GABAergic neurons. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271403 [Multi-domain]  Cd Length: 589  Bit Score: 177.09  E-value: 8.54e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   4 RQQWGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRA 83
Cdd:cd11521    1 RPAWNSKLQYILAQIGYSVGLGNVWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAVGQRIRRGSIGVWNYICPRL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  84 EFIGWWQMCVTFIVSTYYAVIIAWSISYTY--FAITGAWGK--------------------DTQSFLFKEYLHVADKPGQ 141
Cdd:cd11521   81 GGIGYASCLVCFFVGLYYNVIIGWSIFYFFksFQYPLPWSEcpvvrngsvavveaecekssATTYFWYREALDISNSISE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 142 FGGLVPEVLIPLALVWIIVLGVAFKGVKKGIEVV--NRIFIPLLVVMFLiivVRAVTMEGAMQGLDAFFKPDWSRIFDGK 219
Cdd:cd11521  161 SGGLNWKMTLCLLVAWSLVGMAMIKGIQSSGKVMyfSSLFPYVVLVCFL---VRGLLLRGAVDGILHMFTPKLDKMLDPQ 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 220 VWLAAYGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMG------------- 286
Cdd:cd11521  238 VWREAATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKANIMNekcvvenaekilg 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 287 -----------VP-----------------------------------------VDKvASAGVGLAFVVFPQIINELPMS 314
Cdd:cd11521  318 ylntnvlshdlIPphvnfshlttkdynemyrvimtvkedhfkelgldaclledeLDK-SVQGTGLAFIAFTEAMTHFPAS 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 315 PLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKFSLSREKTIGIMGTLLVLVSLVFATRGGLMFLDVVDYFANNFGLITI 394
Cdd:cd11521  397 PFWSVMFFLMLINLGLGSMIGTMSGITTPIIDTFKVRKEVFTVGCCIFAFLVGLIFVQRSGNYFVTMFDDYSATLPLTVV 476
                        490
                 ....*....|.
gi 446372232 395 ALAEVVTIGLI 405
Cdd:cd11521  477 VILENIAVAWI 487
SLC6sbd_NTT5 cd11502
Neurotransmitter transporter 5; solute-binding domain; Human NTT5 is encoded by the SLC6A16 ...
7-402 2.90e-48

Neurotransmitter transporter 5; solute-binding domain; Human NTT5 is encoded by the SLC6A16 gene. NTT5 is expressed in testis, pancreas, and prostate; its expression is predominantly intracellular, indicative of a vesicular location. Its substrates are unknown. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 271392  Cd Length: 535  Bit Score: 174.54  E-value: 2.90e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232   7 WGTRAGFIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRGSAPLTFFRISPRAEFI 86
Cdd:cd11502    4 WSKKTEYILAQVGFSVGLSSIWRFPYLWHHNGGGSFLLIYILMLFLVGIPLLFLEMAVGQRLRQGSIGVWKILSPWLGGV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  87 GWWQMCVTFIVSTYYAVIIAWSISY--------------------TYFAITGAWGKDTQSFLFKEYLHVADKPGQFGGLV 146
Cdd:cd11502   84 GYSSFLVCFIVGLYNNVLNSWSLFYlsqsfqfplpwekcplvknsSDFDPECARTTPSQYFWYRQTLKASDRIEDGGVLV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 147 PEVLIPLALVWIIVLGVAFKGVKKGIEVvnrIFIPLLVVMFLII--VVRAVTMEGAMQGLDAFFKPDWSRIFDGKVWLAA 224
Cdd:cd11502  164 LSLTLSLFLAWCLLCVFMINGLKSTGKM---LYVLVLLPYIILLcfLIRTLFLEGAKFGLKHLLVAKVSALYSLSVWRQA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 225 YGQIFFSLSLAFGIMITYSSYLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMA----------NNMGVPVDKV-- 292
Cdd:cd11502  241 GGQVLYSLGLGFGTIISFSSYMPRSNNCLKDAFLVALVNLVTSLLTTPFIFAVLGFWAtpasiylswlNNLPQHIKSQvl 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 293 --------------ASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAGITSLISLAEVCFAAVSEKFSLSREKT--- 355
Cdd:cd11502  321 skvpecsiqkqkekIMEGPGFAFLAFSEAISLFPGSSFWSILFFLMLLILGLSTMLGIMQGIITPLQDTFSFFRKHPkll 400
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 446372232 356 IGIMGTLLVLVSLVFATRGGLMFLDVVDYFANNFGLITIALAEVVTI 402
Cdd:cd11502  401 TVGVCLLMFLCSLIFTRPSGSYYVSLLDDYWVPMPIIFIVICENLAV 447
SLC5-6-like_sbd cd06857
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
12-412 1.76e-24

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


Pssm-ID: 271356 [Multi-domain]  Cd Length: 407  Bit Score: 105.52  E-value: 1.76e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  12 GFIFAAVGSAVGLGNIWRFPYTAYENGGGaFFLPYLFALLTTGISLLAFEFALGHRHrGSAPLTFFRISPRAEFIGWWQM 91
Cdd:cd06857    2 DLILACIGLALGLANFIRFPQMTYSYGGA-FILPYIVLSIIVGIPLLVLELSMGQFS-GIGFISMWRCSPFFKGLGVVSL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  92 CVTFIVSTYYAVIIAWSISYtyfaITGAWGkdtqsflfkeylhvadkpGQFGGLvpevlipLALVWIIVLGVAFKGVKKg 171
Cdd:cd06857   80 FLSFLLLIYYTYLAALALVY----IINLYY------------------WILALG-------LFLIWVTIYGIFFRGLKS- 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 172 IEVVNRIFIPLLVVMFLIIVVRAVTME--GAMQGLDAFFKPDWSRIFDGKVWLAAYGQIFFSLSLAFGIMITYSSYLPKN 249
Cdd:cd06857  130 IGKLIVIAVIVLLVLLLVLTVRALFLEgaGASEGLNKGGTPDFMELNNSGIWTAATIQVFFSLGAGWGSVITIASFCLFK 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 250 SDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVPVDKVASAGVGLAFVVFPQIINELPMSPLFGVLFFLSLTVAG 329
Cdd:cd06857  210 KNAQRDALIAAFLNLIASIIFVGLIGIAAGVLSFDPQNMVVLGLLNSLYLTFIASPQAISSLAGSNLWAFLYYAALLLAG 289
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 330 ITSLISLAEVCFAAVSEKFSLSREKTIGIMGTLLV-LVSLVFATRGGLMFLDVVDYFANNFGLITIALAEVVTIGLILRR 408
Cdd:cd06857  290 LSSMATITNTVAQSLFDEFRRKLKTGVIDTALIVVlLVAAVIFLVLGLRILFLTDKQLVGTSVVPLLLILLLVVFWIYGR 369

                 ....
gi 446372232 409 LPVY 412
Cdd:cd06857  370 ERIQ 373
Na_transp NF037979
sodium-dependent transporter;
13-369 3.58e-16

sodium-dependent transporter;


Pssm-ID: 468298 [Multi-domain]  Cd Length: 417  Bit Score: 80.36  E-value: 3.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  13 FIFAAVGSAVGLGNIWRFPYTAYENGGGAFFLPYLFALLTTGISLLAFEFALGHRHRgsAPLTFFRISPRAEFI--GWWQ 90
Cdd:NF037979   7 LIFLVAGYAVGIGTFWLFPQFWLQYGLTGLVVYLIFLAVLTYLAILEAESTKKSRYY--IVELYTKVARTPAMIlvLLMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232  91 MCVTFIVSTYYAVIIAWSISYTYFAITGAwgkdtqsflfkeylhvadkpgqfgglvpeVLIPLALVWIIVLGVAFKGVKK 170
Cdd:NF037979  85 LVIFLGVISYYTANGGLLLSPILGTGTLG-----------------------------ILIAKLLMILLAFLILTRAKEK 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 171 GIEVVNRIFI-PLLVVMFLIIVVRAVTMEGAMQGLdAFFKPDWSRIFDG-----KVWLAAYGQIFFSLSLAFGIMITYSS 244
Cdd:NF037979 136 TLDIMAIGSVlFVIFVVVSAILFRSQVLSVAPQAA-QYLSMAKSMIFSFhpitlKLVVDMALQAIYSLGLGFGFYLVLGS 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446372232 245 YLPKNSDTTNNAFITGFANSGFELLAGIGVFAALGFMANNMGVPVDKVASAGVGLAFVVFPQIINELPMSPLFGVLFFLS 324
Cdd:NF037979 215 FLPERFNAKKIIGIGILLQTLLSFLATFTVVYSLGPAHPGYLTAFVYGGEEEAISLFYSLPLILRDVPGGPTLLYLLMLS 294
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 446372232 325 LTVAGITSLISLAEVCFAAVSEKFSLSREKTIGIMGTLLVLVSLV 369
Cdd:NF037979 295 LFLAGLTSILPLGEVGGQIISEVFQLGRNKALIYVLGISLVLGGI 339
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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