|
Name |
Accession |
Description |
Interval |
E-value |
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
3-917 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1545.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 3 YKNTLLMPKTEFPMRGNLPKREPAMQEKWAEMNIYEKVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKS 82
Cdd:COG0060 1 YKETLNLPKTDFPMRANLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 83 MTGFSAPYVPGWDTHGLPIEQALTNK-GVKR---KEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPA 158
Cdd:COG0060 81 MRGFDVPYVPGWDCHGLPIELKVEKElGIKKkdiEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 159 YEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQDKKSASIYVAFPVKDGKNVLEGDEKYI-IWTTTPWTL 237
Cdd:COG0060 161 YEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDVTSPSIYVKFPVKDEKALLLLEDAYLvIWTTTPWTL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 238 PANLGISVHPELEYSIVKV-NDEKYIIASELFETVAKTLEWENAEVVKTVKGSELEYTVAKHPFY-----DRDSLVMLGD 311
Cdd:COG0060 241 PANLAVAVHPDIDYVLVEVtGGERLILAEALVEAVLKELGIEDYEVLATFKGAELEGLRYEHPFYyvvgyDRAHPVILGD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 312 HVTTDAGTGCVHTAPGHGEDDFVVGKKYGLEVLCPVDDKGVLTNEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHS 391
Cdd:COG0060 321 YVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITHS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 392 YPHDWRTKKPIIFRATAQWFASIEAFRKELIEAVAETKWVPAWGETRLHNMVRDRGDWCISRQRAWGVPIPVFYAEN-GD 470
Cdd:COG0060 401 YPHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPEWGEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDcGE 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 471 PIITDETINHVADLFREHGSNVWFEREAKD-LLPEGFTHPGSpNGEFRKETDIMDVWFDSGSSHQAVLEEREDLQRPADL 549
Cdd:COG0060 481 LHRTEEVIGSVAELLEEEGADAWFELDLHRpFLDETLKCPKC-GGTMRRVPDVLDVWFDSGSMHFAVLENREELHFPADF 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 550 YLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDV 629
Cdd:COG0060 560 YLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVASSDYWGDL 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 630 RISDDILKQVAEVYRKIRNTFRFLLGNLDDFKPSENAVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNF 709
Cdd:COG0060 640 RFSDEILKEVRDVYRRLRNTYRFLLANLDDFDPAEDAVPYEDLPELDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNF 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 710 CTIDLSSFYLDFAKDILYIEGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGVTEESVQLTDMPEAVQLD 789
Cdd:COG0060 720 CVEDLSNWYLDISKDRLYTEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLPGEAEESVHLADWPEVDEEL 799
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 790 DAEALKTKWDAFMTLRDDVLKALEVARNEKVIGKSLNASITLYPTAEMKAMLESISEDLKQLFIVSEYKLGGMMDEAPAD 869
Cdd:COG0060 800 IDEELEAKWDLVREVRSAVLKALEAARKEKLIRQPLEAAVVLYADEELAAALESLGDLLAEELNVSEVELVDDAEDLGKD 879
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|...
gi 446378097 870 A-----PKYEHTAVVVVQATGETCERCWVVseTIGKDAEHETLCERCATVVKE 917
Cdd:COG0060 880 AlkaldVEGISVTVEVEKADGEKCERCWHY--EVGWTPEHEGLCRRCVRRVQG 930
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
13-833 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 1146.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 13 EFPMRGNLPKREPAMQEKWAEMNIYEKVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVP 92
Cdd:TIGR00392 1 KFPMRGNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 93 GWDTHGLPIEQALTNK-GV-KRKEMTVAE---FRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVF 167
Cdd:TIGR00392 81 GWDTHGLPIEHKVEKKlGIsGKKEISSLEieeFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 168 GDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQ----DKKSASIYVAFPVKDGKNVLEGDEKY--IIWTTTPWTLPANL 241
Cdd:TIGR00392 161 KEAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYKenykDVKDPSIYVKFPVKKDKKTYLKVKLSslLIWTTTPWTLPSNL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 242 GISVHPELEYSIVKVN--DEKYIIASELFETVAKTLEWeNAEVVKTVKGSELEYTVAKHPFYDRDSL-------VMLGDH 312
Cdd:TIGR00392 241 AIAVHPDFEYALVQDNtkVEYFILAKKLVEKLYNKAGS-DYEIIKTFKGSDLEGLEYEHPLYDFVSQlkegapvVIGGDH 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 313 VTTDAGTGCVHTAPGHGEDDFVVGKKYGLEVLCPVDDKGVLTNEAPGFEGLF-------YDKANKPITEKLEEVGALLKL 385
Cdd:TIGR00392 320 VTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVLSPVDEKGVYTEGVNDFQGRFvkdadkdIIKANKIIIEQLKDKGLLLKA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 386 TFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELIEAVAETKWVPAWGETRLHNMVRDRGDWCISRQRAWGVPIPVFY 465
Cdd:TIGR00392 400 EKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWGEGRFGNWLENRPDWCISRQRYWGIPIPIWY 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 466 AENGDPIITDETINHVADLFREHGSNVWFEREAKDLLPEGFTHPGSPnGEFRKETDIMDVWFDSGSSHQAVLE-----ER 540
Cdd:TIGR00392 480 CEDTGEPIVVGSIEELIELIELKGIDAWFEDLHRDFLDKITLKSGDG-GEYRRVPDVLDVWFDSGSMPYASIHypfenEK 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 541 EDLQRPADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWV 620
Cdd:TIGR00392 559 FKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGADILRLYV 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 621 SSVDYQSDVRISDDILKQVAEVYRKIR-NTFRFLL--GNLDDFKPSENAVAVAELREVDRYMLVKLNDLITKVKEAYETY 697
Cdd:TIGR00392 639 ASSDPWEDLRFSDEILKQVVEKYRKIRwNTYRFLLtyANLDKFDPLFNSVAVEKFPEEDRWILSRLNSLVEEVNEALEKY 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 698 DFAAVYHAIHNFCTIDLSSFYLDFAKDILYIEGANHeDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGVT-EES 776
Cdd:TIGR00392 719 NFHKVLRALQDFIVEELSNWYIRIIRDRLYCEAKDN-DKRAAQTTLYYALLTLVRLLAPFLPHTAEEIYQNLPGGEeEES 797
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446378097 777 VQLTDMPEA------VQLDDAEALKTK-WDAFMTLRDDVLKALEVARNEKVIGKSLNASITLYP 833
Cdd:TIGR00392 798 VHLNLWPEVdeefidEALEANMAIVREiVEAFLALRDAANKKLRQPLKELVIGKSLEAVLKAVE 861
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
16-921 |
0e+00 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 1103.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 16 MRGNLPKREPAMQEKWAEMNIYEKVQEHTKGRPlFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWD 95
Cdd:PLN02843 1 MRANSVTREPEIQKLWEENQVYKRVSDRNNGES-FTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 96 THGLPIE----QALTNKgvKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMA 171
Cdd:PLN02843 80 CHGLPIElkvlQSLDQE--ARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 172 KKGYIYKGQKPVYWSPTSESALAEAEIEY-QDKKSASIYVAFPVKDGKNVLEGDEKYI-------IWTTTPWTLPANLGI 243
Cdd:PLN02843 158 LNGYIYRGRKPVHWSPSSRTALAEAELEYpEGHVSKSIYVAFPVVSPSETSPEELEEFlpglslaIWTTTPWTMPANAAV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 244 SVHPELEYSIVKV----NDE---------------------KYIIASELFETVAKTLEWEnAEVVKTVKGSELEYTVAKH 298
Cdd:PLN02843 238 AVNDKLQYSVVEVqsfsEDEstsggnkkkrpgnvlkeqqklFLIVATDLVPALEAKWGVK-LVVLKTFPGSDLEGCRYIH 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 299 PFYDRDSLVML-GDHVTTDAGTGCVHTAPGHGEDDFVVGKKYGLEVLCPVDDKGVLTNEAPGFEGL-FYDKANKPITEKL 376
Cdd:PLN02843 317 PLYNRESPVVIgGDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLsVLGEGNAAVVEAL 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 377 EEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELIEAVAETKWVPAWGETRLHNMVRDRGDWCISRQRA 456
Cdd:PLN02843 397 DEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPAQGENRIRAMVSGRSDWCISRQRT 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 457 WGVPIPVFY-AENGDPIITDETINHVADLFREHGSNVWFEREAKDLLPEGFTHPGSpngEFRKETDIMDVWFDSGSSHQA 535
Cdd:PLN02843 477 WGVPIPVFYhVETKEPLMNEETIAHVKSIVAQKGSDAWWYMDVEDLLPEKYRDKAS---DYEKGTDTMDVWFDSGSSWAG 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 536 VLEEREDLQRPADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMD------ 609
Cdd:PLN02843 554 VLGSREGLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEggknqk 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 610 ---QLGGDILRLWVSSVDYQSDVRISDDILKQVAEVYRKIRNTFRFLLGNLDDFKPsENAVAVAELREVDRYMLVKLNDL 686
Cdd:PLN02843 634 qepAYGADVLRLWVASVDYTGDVLIGPQILKQMSDIYRKLRGTLRYLLGNLHDWKP-DNAVPYEDLPSIDKYALFQLENV 712
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 687 ITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDILYIEGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVW 766
Cdd:PLN02843 713 VNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGGTTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAEDAW 792
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 767 PYIP----GVTEESVQLTDMPEA----VQLDDAEALktKWDAFMTLRDDVLKALEVARNEKVIGKSLNASITLY-PTAEM 837
Cdd:PLN02843 793 QNLPfqedGSAAESVFEAGWPTPneewLSFPAEDVD--FWSLLLEVRDEVNKVLESARNGKLIGASLEAKVYLHaSDASL 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 838 KAMLESIS------EDLKQLFIVSEYKLGGMMDEAPADAPKYEHTA--------VVVVQATGETCERCWVVSETIGKDAE 903
Cdd:PLN02843 871 AARLAELCgasngaDELRRIFITSQVEVVSSEDDETAACGSYTGEYvegagrvwVGVSRADGSKCERCWNYSPAVGSFSD 950
|
970
....*....|....*...
gi 446378097 904 HETLCERCATVVKENYVK 921
Cdd:PLN02843 951 HPTLCERCYPVVIAQPPP 968
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
26-632 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 782.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 26 AMQEKWAEMNIYEKVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLPIEQAL 105
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 106 TNK-----GVKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQ 180
Cdd:pfam00133 81 EKKlgikeKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 181 KPVYWSPTSESALAEAEIEYQDKKSASIYVAFPVKDGKnvlegDEKYIIWTTTPWTLPANLGISVHPELEYSIvkvNDEK 260
Cdd:pfam00133 161 KLVNWSPALNTALSNLEVEYKDVKGPSIHVAFPLADDE-----GASLVIWTTTPWTLPGNTAVAVNPEFDYVI---TGEG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 261 YIIASELFETVAKTLEweNAEVVKTVKGSELEYTVAKHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFVVGKKYG 340
Cdd:pfam00133 233 YILAEALLKSLYKKGT--DKKILEDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHN 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 341 LEVLCPVDDKGVLTNEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKE 420
Cdd:pfam00133 311 LEVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQ 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 421 LIEAVAETKWVPAWGETRLHNMVRDRGDWCISRQRAWGVPIPVFYAENGDPII-TDETINHVADLFREHGSNVWFEREAK 499
Cdd:pfam00133 391 ALEAVEKVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVcRGELFELVAGRFEEEGSIKWLHREAK 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 500 DLLpegfthpGSPNGEFRKETDIMDVWFDSGSSHQAVL----EEREDLQR--PADLYLEGSDQYRGWFNSSLSTAVAVTG 573
Cdd:pfam00133 471 DKL-------GYGKGTLEQDEDVLDTWFSSGSWPFSTLgwpfVNTEEFKKffPADMLLEGSDQTRGWFYRMIMLSTALTG 543
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 446378097 574 KAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDVRIS 632
Cdd:pfam00133 544 SVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGRDINLS 602
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
9-849 |
9.30e-154 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 472.37 E-value: 9.30e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 9 MPKTEFPMRGNLPKREPAMQEKWAEMNIYEKvqEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFSA 88
Cdd:PRK13208 1 KMMPELPKKYDPEELEEKWQKIWEEEGTYKF--DPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 89 PYVPGWDTHGLPIEQALTNK-GVKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVF 167
Cdd:PRK13208 79 FFPQGWDDNGLPTERKVEKYyGIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 168 GDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQDKKSASIYVAFPVKDGKNVlegdekyIIWTTTPWTLPANLGISVHP 247
Cdd:PRK13208 159 LDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVEDGEEI-------EIATTRPELLPACVAVVVHP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 248 EleysivkvnDEKYiiaSELFETVAKT-LEweNAEVvktvkgseleyTVAKHPFYDRD---SLVML---GDhvttdagtg 320
Cdd:PRK13208 232 D---------DERY---KHLVGKTAIVpLF--GVEV-----------PILADPLVDPDfgtGAVMIctfGD--------- 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 321 cvhtapghgEDDFVVGKKYGLEVLCPVDDKGVLTNEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTKK 400
Cdd:PRK13208 278 ---------KTDVTWWRELNLPTRIIIDEDGRMTEAAGKLAGLTIEEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDT 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 401 PIIFRATAQWFASIEAFRKELIEAVAETKWVPAWGETRLHNMVRD-RGDWCISRQRAWGVPIPVFYAEN-GDPIITDEti 478
Cdd:PRK13208 349 PLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMRVRLENWIEGlNWDWCISRQRYFGTPIPVWYCKDcGHPILPDE-- 426
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 479 nhvADLfrehgsNVwfeREAKDLlPEGFTHPGSPNGEFRKETDIMDVWFDSGSSHQAVL--EEREDLQR---PADLYLEG 553
Cdd:PRK13208 427 ---EDL------PV---DPTKDE-PPGYKCPQCGSPGFEGETDVMDTWATSSITPLIVTgwERDEDLFEkvfPMDLRPQG 493
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 554 SDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDVRISD 633
Cdd:PRK13208 494 HDIIRTWLFYTILRAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVRYWAASARLGSDTPFDE 573
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 634 DILKQVAEVYRKIRNTFRFLLgNLDDFKPSENAvavAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTID 713
Cdd:PRK13208 574 KQVKIGRRLLTKLWNASRFVL-HFSADPEPDKA---EVLEPLDRWILAKLAKVVEKATEALENYDFAKALEEIESFFWHV 649
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 714 LSSFYLDFAKDILYIEGANHEDRRAIQTvLYDVLVALTKLVTPILPHTADEVWPYIPGvteESVQLTDMPEAVQLDDAEA 793
Cdd:PRK13208 650 FCDDYLELVKSRAYGEDEEEEQKSARYT-LYTVLDTLLRLLAPFLPFITEEVWSWLYG---GSVHRASWPEPDEELIDEE 725
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*....
gi 446378097 794 LKTKWDAFMtlrdDVLKALEVARNEKviGKSLNASI---TLYPTAEMKAmLESISEDLK 849
Cdd:PRK13208 726 DEELGELAK----EILSAVRKYKSEA--GLSLNAPLkkvEVYGPADLEL-LEAAEEDLK 777
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
24-867 |
2.60e-145 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 452.59 E-value: 2.60e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 24 EPAMQEKWAEMNIYEKVQEHTKgrPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLP--- 100
Cdd:TIGR00422 11 EKKWYKKWEKSGFFKPDGNSNK--PPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAGIAtqv 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 101 -IEQALTNKGVKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKG 179
Cdd:TIGR00422 89 kVEKKLGAEGKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYEKGLIYRG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 180 QKPVYWSPTSESALAEAEIEYQDKKSASIYVAFPVKDGKNvlegdEKYIIWTTTPWTLPANLGISVHPEleysivkvnDE 259
Cdd:TIGR00422 169 EYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLANGSK-----DYLVVATTRPETMFGDTAVAVHPE---------DE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 260 KYiiaselfetvaKTLewenaeVVKTVKgseleytvakHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFVVGKKY 339
Cdd:TIGR00422 235 RY-----------KHL------IGKKVI----------LPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRH 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 340 GLEVLCPVDDKGVLTNEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRK 419
Cdd:TIGR00422 288 NLEFINILDEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLAD 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 420 ELIEAV--AETKWVPAWGETRLHNMVRDRGDWCISRQRAWGVPIPVFYaengdpiiTDETIN-HVADlfrehgsNVWFER 496
Cdd:TIGR00422 368 KALEAAeeGEIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWY--------CKECGEvYVAK-------EEPLPD 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 497 EAKDLlpegfthpgSPNGEFRKETDIMDVWFDSGSSHQAVL---EEREDLQR--PADLYLEGSDQYRGWFNSSLSTAVAV 571
Cdd:TIGR00422 433 DKTNT---------GPSVELEQDTDVLDTWFSSSLWPFSTLgwpDETKDLKKfyPTDLLVTGYDIIFFWVARMIFRSLAL 503
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 572 TGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSS-VDYQSDVRISDDILKQVAEVYRKIRNTF 650
Cdd:TIGR00422 504 TGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASlVTPGDDINFDWKRVESARNFLNKLWNAS 583
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 651 RFLLGNLDDFKPSENavAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDILYieG 730
Cdd:TIGR00422 584 RFVLMNLSDDLELSG--GEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIWNDFCDWYIELVKYRLY--N 659
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 731 ANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGvTEESVQLTDMPEAV-QLDDAEALKtkwdafmtLRDDVL 809
Cdd:TIGR00422 660 GNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKE-GADSIMLQSYPVVDaEFVDEEAEK--------AFELLK 730
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446378097 810 KALEVARNEKV-IGKSLNASITL---YPTAEMKAMLESISEDLKQLFIVSEYKLGGMMDEAP 867
Cdd:TIGR00422 731 EIIVSIRNLKAeSNIPPNAPLKVlliYTEAETAERLKLNAVDIKGAINFSEVEVVIEKPEVT 792
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
19-856 |
2.40e-133 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 428.76 E-value: 2.40e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 19 NLPKREPAMQEKWAEMNIYEKVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHG 98
Cdd:PLN02882 9 SFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 99 LPIEQALTNK-GVKRKE----MTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKK 173
Cdd:PLN02882 89 LPVEYEIDKKlGIKRRDdvlkMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 174 GYIYKGQKPVYWSPTSESALA--EAEIEYQDKKSASIYVAFP-VKDGKNVlegdeKYIIWTTTPWTLPANLGISVHPELE 250
Cdd:PLN02882 169 GLVYKGFKVMPYSTACKTPLSnfEAGLNYKDVSDPAVMVSFPiVGDPDNA-----SFVAWTTTPWTLPSNLALCVNPNFT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 251 YSIVKVNDEK--YIIA----SELFETVAKTLEWENA-------EVVKTVKGSELeytVAKH-----PFYDRDS----LVM 308
Cdd:PLN02882 244 YVKVRNKYTGkvYIVAesrlSALPTAKPKSKKGSKPenaaegyEVLAKVPGSSL---VGKKyeplfDYFSEFSdtafRVV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 309 LGDHVTTDAGTGCVHTAPGHGEDDF-------VVGKkyGLEVLCPVDDKGVLTNEAPGFEGLFYDKANKPITEKLEEVGA 381
Cdd:PLN02882 321 ADDYVTDDSGTGVVHCAPAFGEDDYrvclangIIEK--GGNLPVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGR 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 382 LLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELIEAVAETKWVPAW-GETRLHNMVRDRGDWCISRQRAWGVP 460
Cdd:PLN02882 399 LVKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYvKEKRFHNWLENARDWAVSRSRFWGTP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 461 IPVFYAENGDPIItdeTINHVADLFREHGSNVW-FEREAKDLLpegfTHPGSPNGEF---RKETDIMDVWFDSGSSHQAV 536
Cdd:PLN02882 479 LPIWISDDGEEVV---VIGSIAELEKLSGVKVTdLHRHFIDHI----TIPSSRGPEFgvlRRVDDVFDCWFESGSMPYAY 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 537 L----EEREDLQR--PADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQ 610
Cdd:PLN02882 552 IhypfENKELFEKnfPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDK 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 611 LGGDILRLWV--SSVDYQSDVRISDD-ILKQVAEVYRKIRNTFRFLLGN--------LDDFKPSENAVAVAELREVDRYM 679
Cdd:PLN02882 632 YGADALRLYLinSPVVRAEPLRFKEEgVFGVVKDVFLPWYNAYRFLVQNakrlevegGAPFVPLDLAKLQNSANVLDRWI 711
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 680 LVKLNDLITKVKEAYETYDFAAVYHAIHNFCTiDLSSFYLDFAKDILYIEGANHEDRRAIQTvLYDVLVALTKLVTPILP 759
Cdd:PLN02882 712 NSATQSLVKFVREEMGAYRLYTVVPYLVKFID-NLTNIYVRFNRKRLKGRTGEEDCRTALST-LYNVLLTSCKVMAPFTP 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 760 HTADEVWPYIPGV---TEESVQLTDMPEAVQLDDAEALKTKWDAFMTLRDDVLKALEvaRNEKVIGKSLNASITLYPTAE 836
Cdd:PLN02882 790 FFTEVLYQNLRKVlpgSEESIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRE--RHNKPLKTPLKEMVVVHPDAE 867
|
890 900
....*....|....*....|
gi 446378097 837 mkaMLESISEDLKQlFIVSE 856
Cdd:PLN02882 868 ---FLDDITGKLKE-YVLEE 883
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
48-631 |
2.80e-118 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 363.86 E-value: 2.80e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 48 PLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLPIEQALTNK-GVK----RKEMTVAEFRK 122
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKElGISgkkdIEKMGIAEFNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 123 LCAEYAYEQVERQREQFKRLGvradwdnpyitlepayeaqqikVFGDMaKKGYIykgqkpvywsptsesalaeaeieyqd 202
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLG----------------------VWVDW-ENPYK-------------------------- 111
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 203 kksasiyvafpvkdgknvlegdekyiiwtttpwTLpanlgisvhpeleysivkvnDEKYIIAselfetvaktlEWEnaeV 282
Cdd:cd00818 112 ---------------------------------TM--------------------DPEYMES-----------VWW---V 124
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 283 VKTvkgseleytvakhpFYDRdslvmlgdhvttdagtgcvhtapghgeddfvvgkkyglevlcpvddkgvltneapgfeG 362
Cdd:cd00818 125 FKQ--------------LHEK----------------------------------------------------------G 132
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 363 LFYdKANKPITekleevgallkltfithsyphdWrtkkPIIFRATAQWFASIEAFRKELIEAVAETKWVPAWGETRLHNM 442
Cdd:cd00818 133 LLY-RGYKVVP----------------------W----PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKNRFGNW 185
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 443 VRDRGDWCISRQRAWGVPIPVFYAENGDPIITdetinhvadlfrehgsnvwfereakdllpegfthpgspngefRKETDI 522
Cdd:cd00818 186 LENRRDWCISRQRYWGTPIPVWYCEDCGEVLV------------------------------------------RRVPDV 223
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 523 MDVWFDSGSSHQAVL---EEREDLQR--PADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKS 597
Cdd:cd00818 224 LDVWFDSGSMPYAQLhypFENEDFEElfPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKS 303
|
570 580 590
....*....|....*....|....*....|....*
gi 446378097 598 IGNIVVPKKIMDQLGGDILRLWVSSVD-YQSDVRI 631
Cdd:cd00818 304 LGNYVDPQEVVDKYGADALRLWVASSDvYAEDLRF 338
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
19-850 |
2.18e-110 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 367.75 E-value: 2.18e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 19 NLPKREPAMQEKWAEMNIYEKVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHG 98
Cdd:PTZ00427 73 NIVEEEEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHG 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 99 LPIEQALTNKG-VKRKE----MTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKK 173
Cdd:PTZ00427 153 LPIEYEIEKENnINKKEdilkMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKN 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 174 GYIYKGQKPVYWSPTSESALA--EAEIEYQDKKSASIYVAF-------------PVKDGKNVL----------------- 221
Cdd:PTZ00427 233 NYVYKSFKVMPYSCKCNTPISnfELNLNYKDTPDPSIIISFvlcsdfpkveeecNIEEDKQLLgekysvlynnkrensnn 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 222 -----------EGDEKYIIWTTTPWTLPANLGISVHPELEY-SIVKVNDEKYIIASEL-FETVAKTLEW--ENAEVVKTV 286
Cdd:PTZ00427 313 gnnnstnnvcyAQHSEILAWTTTPWTLPSNLALCVNEHFTYlRIHHVKSNRVVIVGECrLEWIMKELKWnvEDLKIVNRF 392
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 287 KGSELE---------YTVAKHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFVVGKKYGLE------VLCPVDDKG 351
Cdd:PTZ00427 393 KGKELKglrykplftNFYEKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVIdpekniFIDPLDANG 472
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 352 VLTNEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELIEAVAETKWV 431
Cdd:PTZ00427 473 YFTNEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNNETTYWI 552
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 432 PAW-GETRLHNMVRDRGDWCISRQRAWGVPIPVFYAENGDPIITDETINH---------VADLFREHGSNVWFEReakdl 501
Cdd:PTZ00427 553 PAHiKEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESIKHleelsgvknINDLHRHFIDHIEIKN----- 627
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 502 lPEGFTHPgspngEFRKETDIMDVWFDSGSS-----HQAVLEEREDLQR--PADLYLEGSDQYRGWFNSSLSTAVAVTGK 574
Cdd:PTZ00427 628 -PKGKTYP-----KLKRIPEVFDCWFESGSMpyakvHYPFSTEKEDFHKifPADFIAEGLDQTRGWFYTLLVISTLLFDK 701
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 575 APYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLW-VSSVDYQSD-VRISDdilKQVAEVYRKI----RN 648
Cdd:PTZ00427 702 APFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYlINSVAVRAEnLKFQE---KGVNEVVKSFilpfYH 778
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 649 TFRFLLGNLDDFKPSENAVAVAELREV-------DRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTiDLSSFYLDF 721
Cdd:PTZ00427 779 SFRFFSQEVTRYECLNKKQFLFNTDYIykndnimDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIE-NLTNWYIRL 857
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 722 AKDILYIEGANHEDRRAIQTvLYDVLVALTKLVTPILPHTADEVWPYIP------------------------GVTEESV 777
Cdd:PTZ00427 858 NRDRMRGSLGEENCLQSLCT-TYRTLHLFTVLMAPFTPFITEYIYQQLRrvkstnehnennetgntkegdlnrGVIHKSV 936
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446378097 778 QLTDMPeavQLDDAEALKtkwDAFMTLRDDVLKALEVARN----EKVIGKSLNASIT-LYPTAEMKAMLESISEDLKQ 850
Cdd:PTZ00427 937 HFIMLP---QVDEKYIID---YEIIELIEKMKDVILLGRVlrerRKVASKKPLKSITiLHPNESYFKNFDQISNYIKE 1008
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
56-903 |
6.76e-107 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 350.94 E-value: 6.76e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 56 PPYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGlpI------EQALTNKGVKRKEMTVAEFRKLCAEYAY 129
Cdd:PRK05729 44 PPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPGTDHAG--IatqmvvERQLAAEGKSRHDLGREKFLEKVWEWKE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 130 EQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQDKKSASIY 209
Cdd:PRK05729 122 ESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGKLWH 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 210 VAFPVKDGKNVLEgdekyiIWTTTPWTLPANLGISVHPEleysivkvnDEKYiiaselfetvaKTLewenaeVVKTVKgs 289
Cdd:PRK05729 202 IRYPLADGSDYLV------VATTRPETMLGDTAVAVNPE---------DERY-----------KHL------IGKTVI-- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 290 eleytvakHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFVVGKKYGLEVLCPVDDKGVLTNEAPGFEGLFYDKAN 369
Cdd:PRK05729 248 --------LPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTINENPGEYQGLDRFEAR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 370 KPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELIEAVA--ETKWVPAWGETRLHNMVRDRG 447
Cdd:PRK05729 320 KAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVEngEIKFVPERWEKTYFHWMENIQ 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 448 DWCISRQRAWGVPIPVFYAENGdpiitdetinhvadlfrehgsNVWFEREAKDLLPegfthpgspNGEFRKETDIMDVWF 527
Cdd:PRK05729 400 DWCISRQLWWGHRIPAWYDEDG---------------------EVYVGREEPEARE---------KALLTQDEDVLDTWF 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 528 DSGsshqavL---------EEREDLQR--PadlylegsdqyrgwfNSSLSTA-------VA--------VTGKAPYKGVL 581
Cdd:PRK05729 450 SSA------LwpfstlgwpEKTEDLKRfyP---------------TSVLVTGfdiiffwVArmimmglhFTGQVPFKDVY 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 582 SHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQ-SDVRISDDILKQvaevYR----KIRNTFRFLLGN 656
Cdd:PRK05729 509 IHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPgRDIRFDEERVEG----YRnfanKLWNASRFVLMN 584
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 657 LDDFKPSENAvAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDILYieganHEDR 736
Cdd:PRK05729 585 LEGADVGELP-DPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIWNEFCDWYLELAKPVLQ-----EAAK 658
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 737 RAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGV-TEESVQLTDMPEAVQLDDAEALKtKWDAFMtlrdDVLKALEVA 815
Cdd:PRK05729 659 RATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLgIEESIMLAPWPEADEAIDEAAEA-EFEWLK----ELITAIRNI 733
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 816 RNEKVIGKSLNASITLY-PTAEMKAMLESISEDLKQLFIVSEYKLGGMMDEAPADAPkyehTAVVvvqatgETCERCWVV 894
Cdd:PRK05729 734 RAEMNIPPSKKLPLLLKgADAEDRARLEANEAYIKRLARLESLEILADDEEAPEGAA----SAVV------GGAELFLPL 803
|
....*....
gi 446378097 895 SETIGKDAE 903
Cdd:PRK05729 804 EGLIDVEAE 812
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
56-879 |
4.47e-101 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 335.48 E-value: 4.47e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 56 PPYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDtH-GlpI------EQALTNKGVKRKEMTVAEFrkLcaEYA 128
Cdd:COG0525 43 PPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTD-HaG--IatqavvERQLAEEGKSRHDLGREKF--L--ERV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 129 YEQVERQ----REQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQDKK 204
Cdd:COG0525 116 WEWKEESggtiTNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 205 SASIYVAFPVKDGKNVLegdekyIIWTTTPWTLPANLGISVHPEleysivkvnDEKYiiaselfetvaKTLewenaeVVK 284
Cdd:COG0525 196 GHLWHIRYPLADGSGYI------VVATTRPETMLGDTAVAVHPE---------DERY-----------KHL------IGK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 285 TVKgseleytvakHPFYDR------DslvmlgDHVTTDAGTGCVHTAPGHGEDDFVVGKKYGLEVLCPVDDKGVLTNEAP 358
Cdd:COG0525 244 TVI----------LPLVGReipiiaD------EYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTINENAG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 359 GFEGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELIEAVA--ETKWVPA-WG 435
Cdd:COG0525 308 KYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEdgEIKFVPErWE 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 436 ETRLHNM--VRDrgdWCISRQRAWGVPIPVFYAENGdpiitdetinhvadlfrehgsNVWFEREAKDLLPEgfthpgSPN 513
Cdd:COG0525 388 KTYFHWMenIRD---WCISRQLWWGHRIPAWYCPDG---------------------EVYVARTEPEACAK------AGS 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 514 GEFRKETDIMDVWFDSG----SshqaVL---EEREDLQRpadlYLEGSDqyrgwfnssLSTA-------VA--------V 571
Cdd:COG0525 438 VNLTQDEDVLDTWFSSAlwpfS----TLgwpEKTEDLKY----FYPTSV---------LVTGfdiiffwVArmimmglhF 500
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 572 TGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRL-WVSSVDYQSDVRISDDILKQvaevYR----KI 646
Cdd:COG0525 501 TGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFtLAALASPGRDIKFDEERVEG----YRnfanKL 576
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 647 RNTFRFLLGNLDDFKPSENAvAVAELREVDRYMLVKLNDLITKVKEAYETYDFA----AVYHAI-HNFCtidlsSFYLDF 721
Cdd:COG0525 577 WNASRFVLMNLEGFDPGLDP-DPEELSLADRWILSRLNKTIAEVTEALEKYRFDeaaqALYDFVwNEFC-----DWYLEL 650
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 722 AKDILYieGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIP-GVTEESVQLTDMPEAV-QLDDAEALKtkwd 799
Cdd:COG0525 651 AKPRLY--GGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPpRKEGESIMLAPWPEADeELIDEEAEA---- 724
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 800 AFMTLRdDVLKALEVARNEKVIGKSLNASITLY-PTAEMKAMLESISEDLKQLFIVSEYKLGGmmDEAPADAPkyehTAV 878
Cdd:COG0525 725 EFEWLK-EVISAIRNIRAEMNIPPSKKLPLLLKgADEADRARLEENAAYIKRLARLEEITILV--DEKPEGAA----SAV 797
|
.
gi 446378097 879 V 879
Cdd:COG0525 798 V 798
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
631-809 |
3.31e-95 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 297.13 E-value: 3.31e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 631 ISDDILKQVAEVYRKIRNTFRFLLGNLDDFKPSENAVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFC 710
Cdd:cd07960 1 ISDEILKQVAEAYRKIRNTFRFLLGNLNDFDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 711 TIDLSSFYLDFAKDILYIEGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGVT-EESVQLTDMPEAVQLD 789
Cdd:cd07960 81 TVDLSAFYLDIIKDRLYCDAKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEKkEESVFLEDWPELPEEW 160
|
170 180
....*....|....*....|
gi 446378097 790 DAEALKTKWDAFMTLRDDVL 809
Cdd:cd07960 161 KDEELEEKWEKLLALRDEVN 180
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
31-793 |
8.98e-93 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 316.55 E-value: 8.98e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 31 WAEMNiYEKVQEHTKGRPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLP----IEQALT 106
Cdd:PRK14900 32 WQERG-YFHGDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIAtqmiVEKELK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 107 N-KGVKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYW 185
Cdd:PRK14900 111 KtEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEGLIYREKKLINW 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 186 SPTSESALAEAEIEYQDKKSASIY-VAFPVKDgknvleGDEKYIIWTTTPWTLPANLGISVHPEleysivkvnDEKYiia 264
Cdd:PRK14900 191 CPDCRTALSDLEVEHEEAHQGELWsFAYPLAD------GSGEIVVATTRPETMLGDTAVAVHPL---------DPRY--- 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 265 selfetvaktleweNAEVVKTVkgseleytvaKHPFYDRDsLVMLGDHVTTDA--GTGCVHTAPGHGEDDFVVGKKYGLE 342
Cdd:PRK14900 253 --------------MALHGKKV----------RHPITGRT-FPIVADAILVDPkfGTGAVKVTPAHDFNDFEVGKRHGLE 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 343 VLCPVDDKGVLTNEAPGFEGLFYDKANKPITEKLEEVGALLKltfithSYPHDW------RTKKPIIFRATAQWFASIEA 416
Cdd:PRK14900 308 MITVIGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQGLDRG------AKPHVLplgrcqRSATILEPLLSDQWYVRIEP 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 417 FRKELIEAVAE--TKWVP-AWGETRLHNMvRDRGDWCISRQRAWGVPIPVFYAENGDPIITDETinhvadlfrehgsnvw 493
Cdd:PRK14900 382 LARPAIEAVEQgrTRFIPeQWTNTYMAWM-RNIHDWCISRQLWWGHQIPAWYCPDGHVTVARET---------------- 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 494 fereakdllPEGFTHPGSpnGEFRKETDIMDVWFDSG---SSHQAVLEEREDLQR--PADLYLEGSDQYRGWFNSSLSTA 568
Cdd:PRK14900 445 ---------PEACSTCGK--AELRQDEDVLDTWFSSGlwpFSTMGWPEQTDTLRTfyPTSVMETGHDIIFFWVARMMMMG 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 569 VAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQS-DVRISDDILKQVAEVYRKIR 647
Cdd:PRK14900 514 LHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGrDIKLAKERIEGYRAFANKLW 593
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 648 NTFRFLLGNLDDFKPSENAVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDILY 727
Cdd:PRK14900 594 NASRFALMNLSGYQERGEDPARLARTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDWYIELAKEALA 673
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446378097 728 ieGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIP-----GVTEESVQLTDMPEAVQLDD-AEA 793
Cdd:PRK14900 674 --SEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRaqvgaSAWADSVLAAEYPRKGEADEaAEA 743
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
30-875 |
2.87e-83 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 288.38 E-value: 2.87e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 30 KWAEMNIYEKVQEHTKGRPlFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHG----LPIEQAL 105
Cdd:PLN02943 71 NWWESQGYFKPNFDRGGDP-FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGiatqLVVEKML 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 106 TNKGVKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYW 185
Cdd:PLN02943 150 ASEGIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSYMVNW 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 186 SPTSESALAEAEIEYQDKKSASIYVAFPVKDGKnvlegDEKYIIWTTTPWTLPANLGISVHPEleysivkvnDEKYIias 265
Cdd:PLN02943 230 SPNLQTAVSDLEVEYSEEPGTLYYIKYRVAGGS-----EDFLTIATTRPETLFGDVAIAVNPE---------DDRYS--- 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 266 elfETVAKTlewenAEVVKTvkgseleytvakhpfYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFVVGKKYGLEVLC 345
Cdd:PLN02943 293 ---KYIGKM-----AIVPMT---------------YGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILN 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 346 PVDDKGVLTNEApgfeGLFYDKANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELIEAV 425
Cdd:PLN02943 350 VMNKDGTLNEVA----GLYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAV 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 426 --AETKWVPAWGETRLHNMVRDRGDWCISRQRAWGVPIPVFYAENGDpiITDETInhVAdlfrehgsnvwfeREAKDLLP 503
Cdd:PLN02943 426 enGELTIIPERFEKIYNHWLSNIKDWCISRQLWWGHRIPVWYIVGKD--CEEDYI--VA-------------RSAEEALE 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 504 EGFTHPGSpNGEFRKETDIMDVWFDSGSSHQAVL----EEREDLQR--PADLYLEGSDQYRGWFNSSLSTAVAVTGKAPY 577
Cdd:PLN02943 489 KAREKYGK-DVEIYQDPDVLDTWFSSALWPFSTLgwpdVSAEDFKKfyPTTVLETGHDILFFWVARMVMMGIEFTGTVPF 567
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 578 KGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDVRISDDILKQVAEVYRKIRNTFRFLLGNL 657
Cdd:PLN02943 568 SYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTAGQDLNLSTERLTSNKAFTNKLWNAGKFVLQNL 647
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 658 ---DDFKPSENAVA--------VAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDIL 726
Cdd:PLN02943 648 psqSDTSAWEHILAckfdkeesLLSLPLPECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWSDFADWYIEASKTRL 727
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 727 YIEGANHEDRRAiQTVLYDVLVALTKLVTPILPHTADEVWPYIPGvTEESVQLTDMPEAVQLDDAEALKtKWDAFMTLrd 806
Cdd:PLN02943 728 YHSGDNSALSRA-QAVLLYVFENILKLLHPFMPFVTEELWQALPY-RKEALIVSPWPQTSLPKDLKSIK-RFENLQSL-- 802
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446378097 807 dvLKALEVARNEKVIGKSLNASITLYPTAEmkaMLESISEDLKQLFIVSEYKLGGM--MDEAPADAPKYEH 875
Cdd:PLN02943 803 --TRAIRNARAEYSVEPAKRISASIVASAE---VIEYISKEKEVLALLSRLDLQNVhfTDSPPGDANQSVH 868
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
1-852 |
1.62e-82 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 286.90 E-value: 1.62e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 1 MEYKNTLLMPKTEFPMRGNLPKREPAMQEKWAE---MNIYEK--------VQEHTKGRPLFVLHDGPPYANGDIHMGHAL 69
Cdd:PTZ00419 2 MKKEEIKLSKDEKKNKKRNISSMAASYDPKEVEsgwYEWWEKsgffkpaeDAKSLNSGKKFVIVLPPPNVTGYLHIGHAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 70 NKVLKDFIVRYKSMTGFSAPYVPGWDTHGLP----IEQALTNK-GVKRKEMTVAEFRKLCAEYAYEQVERQREQFKRLGV 144
Cdd:PTZ00419 82 TGAIQDSLIRYHRMKGDETLWVPGTDHAGIAtqvvVEKKLMKEeNKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 145 RADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYQD-KKSASI--------------- 208
Cdd:PTZ00419 162 SLDWSREVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEiEKPTKItipgydkkvevgvlw 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 209 YVAFPVKDGknvleGDEKYIIWTTTPWTLPANLGISVHPeleysivkvNDEKYiiaselfetvaktlewenaevvKTVKG 288
Cdd:PTZ00419 242 HFAYPLEDS-----GQEEIVVATTRIETMLGDVAVAVHP---------KDERY----------------------KKLHG 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 289 SELeytvaKHPFY-DRDSLVMLGD-HVTTDAGTGCVHTAPGHGEDDFVVGKKYGLEVLCPVDDKGVLTNEAPGFEGLFYD 366
Cdd:PTZ00419 286 KEL-----IHPFIpDRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGKINENGGEFAGMHRF 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 367 KANKPITEKLEEVGALLKLTFITHSYPHDWRTKKPIIFRATAQWFASIEAFRKELIEAV--AETKWVPAWGETRLHNMVR 444
Cdd:PTZ00419 361 DCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAVrnGELKIIPSSHENVWYHWLE 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 445 DRGDWCISRQRAWGVPIPVFY--AENGDPIITDETINHVADLFREHGSNVwfeREAKDLLPEGFthpgspngEFRKETDI 522
Cdd:PTZ00419 441 NIQDWCISRQLWWGHRIPAYRviSKGPETDPSDEEPWVVARSEEEALEKA---KKKFGLSEEDF--------ELEQDEDV 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 523 MDVWFDSGSSHQAVL---EEREDLQR--PADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKS 597
Cdd:PTZ00419 510 LDTWFSSGLFPFSTLgwpDQTDDLQRffPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKS 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 598 IGNIVVPKKIMD-------------------------------------QLGGDILRLWVSSvdYQSDVR-ISDDILKQV 639
Cdd:PTZ00419 590 KGNVIDPLEVIEgislqdlnqklyegnlpekeikraielqkkefpngipECGTDALRFGLLA--YTQQGRnINLDINRVV 667
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 640 AevYR----KIRNTFRFLLGNLDDFKPS-----ENAVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFC 710
Cdd:PTZ00419 668 G--YRhfcnKLWNAVKFALMKLLKDFNLpnstlFKPNNVESLPWEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFW 745
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 711 TIDLSSFYLDFAKDILyIEGANHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIPGVTE--ESVQLTDMPEAVQL 788
Cdd:PTZ00419 746 LYELCDVYLELIKPRL-SKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPNYLRksESISIAKYPQPNPG 824
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446378097 789 DDAEALKTKWDAFMtlrdDVLKALevarnekvigKSLNASITLYPTAEMKAMLESISEDLKQLF 852
Cdd:PTZ00419 825 WNNEALDEEMKIIM----SIVKSI----------RSLIATLGIPNKTKPDCYVTAKDAELIELI 874
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
56-636 |
1.46e-73 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 246.77 E-value: 1.46e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 56 PPYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLP----IEQALTNKGVKRKEMTVAEFRKLCAEYAYEQ 131
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIAtqvvVEKKLGIEGKTRHDLGREEFLEKCWEWKEES 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 132 VERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIEYqdkksasiyva 211
Cdd:cd00817 89 GGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEVCS----------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 212 fpvkDGKNVLEgdekyiiwtttpwtlpanlgisvhpeleysivkvndekyiiaselfetvaktlewenaevvktvkgsel 291
Cdd:cd00817 158 ----RSGDVIE--------------------------------------------------------------------- 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 292 eytvakhpfydrdslvmlgdhvttdagtgcvhtapghgeddfvvgkkyglevlcpvddkgvltneapgfeglfydkankP 371
Cdd:cd00817 165 -------------------------------------------------------------------------------P 165
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 372 ITEKleevgallkltfithsyphdwrtkkpiifrataQWFASIEAFRKELIEAVAE--TKWVPAWGETRLHNMVRDRGDW 449
Cdd:cd00817 166 LLKP---------------------------------QWFVKVKDLAKKALEAVKEgdIKFVPERMEKRYENWLENIRDW 212
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 450 CISRQRAWGVPIPVFYAENGDPIITDETinhvadlfrehgsnvwfEREAKDLLPEGFTHPGSPNgEFRKETDIMDVWFDS 529
Cdd:cd00817 213 CISRQLWWGHRIPAWYCKDGGHWVVARE-----------------EDEAIDKAAPEACVPCGGE-ELKQDEDVLDTWFSS 274
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 530 GSSHQAVL---EEREDLQR--PADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVP 604
Cdd:cd00817 275 SLWPFSTLgwpEETKDLKKfyPTSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDP 354
|
570 580 590
....*....|....*....|....*....|..
gi 446378097 605 KKIMDQLGGDILRLWVSSVdyqsdVRISDDIL 636
Cdd:cd00817 355 LDVIDGYGADALRFTLASA-----ATQGRDIN 381
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
50-631 |
4.26e-64 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 218.44 E-value: 4.26e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 50 FVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLPIEQALTNKGVKRKEMT-VAEFRKLCAEYA 128
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIwIEEFREDPKEFV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 129 YEQVERQreqfkrlgvRADWDNpyitlepayeaqqikvfgdmakkgyiykgqkpvywsptsesalaeaeieyqdkksasi 208
Cdd:cd00668 82 EEMSGEH---------KEDFRR---------------------------------------------------------- 94
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 209 yvafpvkdgknvlegdekyiiwtttpwtlpanLGISVHPELEYSivkvndekyiiaselfetvakTLEWENAEVVktvkg 288
Cdd:cd00668 95 --------------------------------LGISYDWSDEYI---------------------TTEPEYSKAV----- 116
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 289 sELEYTVAKHpfydrdslvmlgdhvttdagtgcvhtapghgeddfvvgkkyglevlcpvddkgvltneapgfEGLFYdka 368
Cdd:cd00668 117 -ELIFSRLYE--------------------------------------------------------------KGLIY--- 130
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 369 nkpitekleevgallkltfithsyphdwrtKKPIIFRATAQWFASIEAFRKELIEAVAETKWVPAWGETRLHNMVRDRGD 448
Cdd:cd00668 131 ------------------------------RGTHPVRITEQWFFDMPKFKEKLLKALRRGKIVPEHVKNRMEAWLESLLD 180
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 449 WCISRQRAWGVPIPvfyaengdpiitdetinhvadlfrehgsnvwfereakdllpegfthpgspngefrkeTDIMDVWFD 528
Cdd:cd00668 181 WAISRQRYWGTPLP---------------------------------------------------------EDVFDVWFD 203
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 529 SGSSHQAVLEEREDLQR-----PADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVV 603
Cdd:cd00668 204 SGIGPLGSLGYPEEKEWfkdsyPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVID 283
|
570 580
....*....|....*....|....*....
gi 446378097 604 PKKIMDQLGGDILRLWV-SSVDYQSDVRI 631
Cdd:cd00668 284 PSDVVEKYGADALRYYLtSLAPYGDDIRL 312
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
47-869 |
1.87e-58 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 217.84 E-value: 1.87e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 47 RPLFVLHDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLPIEQALTNKGVKRKEMT---------V 117
Cdd:PLN02381 127 KPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKLMRERHLTrhdigreefV 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 118 AEFRKLCAEYAYEQVErqreQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAE 197
Cdd:PLN02381 207 SEVWKWKDEYGGTILN----QLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVE 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 198 IEYQDKKSASIY----VAFPVKDGKNV-----LEGDEKYIIWTTTPW-TLPANLGISVHPEleysivkvnDEKYiiasel 267
Cdd:PLN02381 283 VDYIDIKERTLLkvpgYDKPVEFGVLTsfaypLEGGLGEIVVATTRIeTMLGDTAIAIHPD---------DERY------ 347
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 268 fetvaktlewenaevvktvkgSELEYTVAKHPFYDRdSLVMLGDHVTTDA--GTGCVHTAPGHGEDDFVVGKKYGLEVLC 345
Cdd:PLN02381 348 ---------------------KHLHGKFAVHPFNGR-KLPIICDAILVDPnfGTGAVKITPAHDPNDFEVGKRHNLEFIN 405
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 346 PVDDKGVL-TNEAPGFEGLFYDKANKPITEKLEEVGAL-------LKLTFITHSYphdwRTKKPIIfraTAQWFASIEAF 417
Cdd:PLN02381 406 IFTDDGKInSNGGSEFAGMPRFAAREAVIEALQKKGLYrgaknneMRLGLCSRTN----DVVEPMI---KPQWFVNCSSM 478
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 418 RKELIEAVAETK-----WVPAWGETRLHNMVRDRGDWCISRQRAWGVPIPVFYAENGDpiitdetinhvaDLFREHGSNV 492
Cdd:PLN02381 479 AKQALDAAIDGEnkkleFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYVTLED------------DQLKELGSYN 546
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 493 --WF-EREAKDLLPEGFTHPGSPNGEFRKETDIMDVWFDSGSSHQAVL---EEREDLQR--PADLYLEGSDQYRGWFNSS 564
Cdd:PLN02381 547 dhWVvARNESDALLEASQKFPGKKFELSQDPDVLDTWFSSGLFPLSVLgwpDDTDDLKAfyPTSVLETGHDILFFWVARM 626
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 565 LSTAVAVTGKAPYKGVLSHGFVLDGEGRKMSKSIGNIVVPKKIMD----------------------------------- 609
Cdd:PLN02381 627 VMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINgisleglhkrleegnldpkelvvakegqkkdfpng 706
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 610 --QLGGDILRLWVSSVDYQSDvRISDDILKQVAevYR----KIRNTFRFLLGNLDDFKPSENAVAVAELREVDRYMLVKL 683
Cdd:PLN02381 707 iaECGTDALRFALVSYTAQSD-KINLDILRVVG--YRqwcnKLWNAVRFAMSKLGDDYTPPATLSVETMPFSCKWILSVL 783
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 684 NDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDilYIEGANHE---DRRAIQTVLYDVLVALTKLVTPILPH 760
Cdd:PLN02381 784 NKAISKTVSSLDAYEFSDAASTVYSWWQYQFCDVFIEAIKP--YFAGDNPEfasERAAAQDTLWICLDTGLRLLHPFMPF 861
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 761 TADEVWPYIPGVT----EESVQLTDMPEAVQLDDAEALKTKwdafMTLRDDVLKALEVARNEkVIGKSLNASITLYPTAE 836
Cdd:PLN02381 862 VTEELWQRLPQPKdhtrKDSIMISEYPSAVEAWTNEKVEYE----MDLVLSTVKCLRSLRAE-VLEKQKNERLPAFALCR 936
|
890 900 910
....*....|....*....|....*....|....*....
gi 446378097 837 MKAMLESISEdlKQLFIVSEYKLGGMM------DEAPAD 869
Cdd:PLN02381 937 NQEIAAIIKS--HQLEILTLANLSSLKvllsenDAPPAG 973
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
24-769 |
8.39e-49 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 186.88 E-value: 8.39e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 24 EPAMQEKWAEMNIYEKVQEHTKGRpLFVLhDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLPIEQ 103
Cdd:TIGR00396 7 EEKWQQKWDENKTFKVTDDSSKPK-YYIL-SMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGLPAEN 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 104 ALTNKGVKRKEMTvaefrklcaeyaYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPV 183
Cdd:TIGR00396 85 AAIKRGIHPAKWT------------YENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 184 YWSPTSESALAEAEIEYQDK--------------------------------------------------KSASIYVAFP 213
Cdd:TIGR00396 153 NWCPNDGTVLANEQVDSDGRswrgdtpvekkelkqwflkitayaeellndleeldhwpesvkemqrnwigKSEGVEITFK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 214 VKDgknvleGDEKYIIWTTTPWTLPANLGISVHPE--LEYSIVKVNDE--KYIIASELFETVAKTLEwenaevvKTVKGS 289
Cdd:TIGR00396 233 IAD------HDEKITVFTTRPDTIFGVTYLALAPEhpLVEKAAENNPKvaAFIKKILNKTVAERTKA-------TKEKKG 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 290 ELEYTVAKHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFVVGKKYGL---EVLCPVD----------DKGVLTNE 356
Cdd:TIGR00396 300 VDTGIKAIHPLTGEKIPIWVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLpikPVIDPAEkdlsltaaytEDGVLVNS 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 357 APgFEGLFYDKANKPITEKLEEVGallkltfithsyphdwRTKKPIIFRataqwfasieafrkelieavaetkwvpawge 436
Cdd:TIGR00396 380 GE-FNGLNSSEARNAIIDMLEKEG----------------KGKRKVNYR------------------------------- 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 437 trlhnmVRdrgDWCISRQRAWGVPIPVFYAENGD---------PIITDETINHVADlfreHGSNVWFEREAKDLLPEGFT 507
Cdd:TIGR00396 412 ------LR---DWGFSRQRYWGEPIPIIHCEDGGvvpvpeedlPVILPEDVVYDGD----GGSPLSRIPEWVNVTCPSCG 478
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 508 HPGspngefRKETDIMDVWFDSG--------SSHQAVLEEREDLQR--PADLYLEGSDQ------YRGWFNSSLSTAVAV 571
Cdd:TIGR00396 479 KPA------LRETDTMDTFAGSSwyylryldPKNTDGPFDKEKAEYwlPVDLYIGGIEHailhllYARFFHKFLRDIGYV 552
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 572 TGKAPYKGVLSHGFVL------DGE-------------------------GRKMSKSIGNIVVPKKIMDQLGGDILRLWV 620
Cdd:TIGR00396 553 NTKEPFKKLINQGMVLgfyyppNGKvpadvlterdekgkdkaggelvyvgYEKMSKSKGNGIDPQEIVESYGADALRLFI 632
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 621 SsvdYQSDvrISDDILKQVAevyrKIRNTFRFL-----LGNLDDFKPSENAVAVAELREVDRYMLVKLNDLITKVKEAYE 695
Cdd:TIGR00396 633 M---FMGP--IAASLEWNES----GLEGARRFLdrvwnLVYEITGELDAASLTVTALEEAQKELRRDVHKFLKKVTEDLE 703
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446378097 696 T-YDFAAVYHAIhnfctIDLSSFYLDFAKDILYIEGanhedrraiqtvlydvLVALTKLVTPILPHTADEVWPYI 769
Cdd:TIGR00396 704 KrESFNTAISAM-----MELLNKLYKAKKEALMLEY----------------LKGFVTVLSPFAPHLAEELWEKL 757
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
24-766 |
3.60e-45 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 176.17 E-value: 3.60e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 24 EPAMQEKWAEMNIYEKVQEHTKGRPLFVLHDGPPYANG-DIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLPIE 102
Cdd:PLN02563 86 EPKWQRYWEENRTFRTPDDVDTSKPKFYVLDMFPYPSGaGLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLPAE 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 103 QALTNKGVKRKEMTVAefrklcaeyayeQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKP 182
Cdd:PLN02563 166 QYAIETGTHPKITTLK------------NIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVP 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 183 VYWSPTSESALAEAEI-------------------------EYQDK-----------------------KSASIYVAFPV 214
Cdd:PLN02563 234 VNWCPALGTVLANEEVvdglsergghpvirkpmrqwmlkitAYADRlledlddldwpesikemqrnwigRSEGAELDFSV 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 215 KDGkNVLEGDEKYIIWTTTPWTLPANLGISVHPE--LEYSIVKVNDEKYIiaSELFETVAKTLEWENAEVVKtVKGSELE 292
Cdd:PLN02563 314 LDG-EGKERDEKITVYTTRPDTLFGATYLVVAPEhpLLSSLTTAEQKEAV--EEYVDAASRKSDLERTELQK-EKTGVFT 389
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 293 YTVAKHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFVVGKKYGLE---VLCPVDDK-----------GVLTN--- 355
Cdd:PLN02563 390 GSYAINPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPikwVVKPADGNeddaekaytgeGVIVNsss 469
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 356 EAPGFEGLFYDKANKPITEKLEEVGAllkltfithsyphdwrtkkpiifrataqwfasieafrkelieavaetkwvpawG 435
Cdd:PLN02563 470 SGLDINGLSSKEAAKKVIEWLEETGN-----------------------------------------------------G 496
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 436 ETRLHNMVRdrgDWCISRQRAWGVPIPVFYAENGD---PIITDETINHVADL--FREHGSNVWFEREAKDLLPEGFTHPG 510
Cdd:PLN02563 497 KKKVNYKLR---DWLFARQRYWGEPIPVVFLEDSGepvPVPESDLPLTLPELddFTPTGTGEPPLAKAVSWVNTVDPSSG 573
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 511 SPngeFRKETDIMDVW----------FDSGSSHQAVLEEREDLQRPADLYLEGSDQ------YRGWFNSSLSTAVAVTGK 574
Cdd:PLN02563 574 KP---ARRETNTMPQWagscwyylrfMDPKNSNALVDKEKEKYWMPVDLYVGGAEHavlhllYARFWHKVLYDIGVVSTK 650
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 575 APYKGVLSHGFVL---------DGEGR---------------------------------------------KMSKSIGN 600
Cdd:PLN02563 651 EPFQCLVNQGMILgeveytafkDSDGEyvsadtadrlgelqqekipeekviksgdsfvlkddpsirliarahKMSKSRGN 730
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 601 IVVPKKIMDQLGGDILRLWVSSVDYQSDVRISDDilKQVAEVYRKIRNTFRFLLGN-LDDFKPSENAVAVAElrEVDRYM 679
Cdd:PLN02563 731 VVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWST--SGVEGVHRFLGRTWRLVVGApLPDGSFRDGTVVTDE--EPSLEQ 806
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 680 LVKLNDLITKVKEAYETYDFAAVYHAIHNFctidlssfyldfakdilyIEGANHEDRRAIQtvlydVLVALTKLVTPILP 759
Cdd:PLN02563 807 LRLLHKCIAKVTEEIESTRFNTAISAMMEF------------------TNAAYKWDKVPRE-----AIEPFVLLLSPYAP 863
|
....*..
gi 446378097 760 HTADEVW 766
Cdd:PLN02563 864 HLAEELW 870
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
24-795 |
1.15e-43 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 171.00 E-value: 1.15e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 24 EPAMQEKWAEMNIYeKVQEHTKGRPLFVLhDGPPYANGDIHMGHALNKVLKDFIVRYKSMTGFSapyV--P-GWDTHGLP 100
Cdd:COG0495 11 EKKWQKYWEENGTF-KADEDSSKPKYYVL-DMFPYPSGRLHMGHVRNYTIGDVVARYKRMQGYN---VlhPmGWDAFGLP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 101 IEQALTNKGVKRKEMTvaefrklcaeyaYEQVERQREQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQ 180
Cdd:COG0495 86 AENAAIKNGVHPAEWT------------YENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 181 KPVYWSPTSESALA------------EAEIE-------------YQDK------------------------KSASIYVA 211
Cdd:COG0495 154 APVNWCPVDQTVLAneqvidgrcwrcGAPVEkkelpqwflkitdYADEllddldkldgwpekvktmqrnwigRSEGAEVD 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 212 FPVKDGKNVLEgdekyiIWTTTPWTLpanLGIS--V----HPeleysIVkvndeKYIIASELFETVAKTLEwenaevvKT 285
Cdd:COG0495 234 FPVEGSDEKIT------VFTTRPDTL---FGATfmVlapeHP-----LV-----KELATPEQNAAVAAFIE-------EA 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 286 VKGSELEYTV-------------AKHPFyDRDSL-VMLGDHVTTDAGTGCVHTAPGHGEDDFVVGKKYGL---EVLCPVD 348
Cdd:COG0495 288 KKKSEIERTSetkektgvftglyAINPL-TGEKIpIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLpikQVIAPED 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 349 D------------KGVLTNEAPgFEGLFYDKANKPITEKLEEVGallkltfithsyphdwrtkkpiIFRATAQWfasiea 416
Cdd:COG0495 367 GddpdileeaytgDGVLINSGE-FDGLDSEEAKEAIIEWLEEKG----------------------LGKRKVNY------ 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 417 frkelieavaetkwvpawgetRLHnmvrdrgDWCISRQRAWGVPIPVFYAENGDPIITDEtinhvadlfrehgsnvwfer 496
Cdd:COG0495 418 ---------------------RLR-------DWLISRQRYWGEPIPIIHCEDCGVVPVPE-------------------- 449
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 497 eaKDL---LPEG--FT-HPGSP---------------NGEFRKETDIMDVWFDS----------GSSHQAVLEEREDLQR 545
Cdd:COG0495 450 --DQLpveLPEDvdFDpTGGSPlarapewvnvtcpkcGGPARRETDTMDTFVDSswyylrytdpHNDEAPFDPEAANYWL 527
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 546 PADLYLEGSDQ------Y-RGWfnsslsTAV-----AVTGKAPYKGVLSHGFVLD--------GEGRKMSKSIGNIVVPK 605
Cdd:COG0495 528 PVDQYIGGIEHailhllYaRFF------TKVlrdlgLVSFDEPFKRLLTQGMVLEvgkdgvviGGIEKMSKSKGNVVDPD 601
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 606 KIMDQLGGDILRLWVSSV-DYQSDVRISDdilKQVAEVYRKIRNTFRFLLGNLDDFKpsenaVAVAELREVDRYMLVKLN 684
Cdd:COG0495 602 EIIEKYGADTLRLFEMFAgPPERDLEWSD---SGVEGAYRFLNRVWRLVVDEAEALK-----LDVADLSEADKELRRALH 673
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 685 DLITKVKEAYETYDF----AAVYhaihnfctidlssfylDFAKDILYIEGANHEDRRAIQtvlyDVLVALTKLVTPILPH 760
Cdd:COG0495 674 KTIKKVTEDIERLRFntaiAALM----------------ELVNALYKAKDSGEADRAVLR----EALETLVLLLAPFAPH 733
|
890 900 910
....*....|....*....|....*....|....*
gi 446378097 761 TADEVWPYIPGvtEESVQLTDMPEAvqldDAEALK 795
Cdd:COG0495 734 IAEELWERLGH--EGSVADAPWPEA----DEAALV 762
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
63-867 |
1.10e-34 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 143.09 E-value: 1.10e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 63 IHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLPIeQALTNKGVKRKEMTVAEFRKLC----------------AE 126
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPI-LGIAERIARGDPETIELYKSLYgipeeelekfkdpeyiVE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 127 YAYEQVErqrEQFKRLGVRADWDNPYITLEPAYEA----QqikvFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIeyQD 202
Cdd:PRK12300 80 YFSEEAK---EDMKRIGYSIDWRREFTTTDPEYSKfiewQ----FRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDL--LD 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 203 KKSASI--YVAfpVKdgknvLEGDEKYIIWTTT--PWTLPANLGISVHPELEYSIVKVNDEKYIIASELFETVAKTLEwe 278
Cdd:PRK12300 151 GEEPEIveYTL--IK-----FEESEDLILPAATlrPETIFGVTNLWVNPDATYVKAEVDGEKWIVSKEAAEKLSFQDR-- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 279 NAEVVKTVKGSELEYTVAKHPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFVV-----GKKYGLEVLCPV------ 347
Cdd:PRK12300 222 DVEIIEEIKGSELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDYVAlrdlkKNKELLDVIEPIplieve 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 348 -------------------DD----------------KGVLTNEAPGFEGLFYDKANKPITEKLEEVGALLKLTFITHsy 392
Cdd:PRK12300 302 gygefpakevveklgiksqEDpeleeatkevyraefhKGVLKENTGEYAGKPVREAREKITKDLIEKGIADIMYEFSN-- 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 393 phdwrtkKPIIFRATA---------QWFA--SIEAFRKELIEAVAETKWVPawGETR--LHNMVRDRGDWCISRQRAWGV 459
Cdd:PRK12300 380 -------RPVYCRCGTecvvkvvkdQWFIdySDPEWKELAHKALDNMEIIP--EEYRkeFENTIDWLKDRACARRRGLGT 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 460 PIPVfyaengDP--II---TDETINH----VADLFREHGSNvwfereAKDLLPEGFTHPgspngeFRKETDIMDVWFDSG 530
Cdd:PRK12300 451 RLPW------DEewIIeslSDSTIYMayytIAHKIREYGIK------PEQLTPEFFDYV------FLGKGDPEEVSKKTG 512
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 531 SSHQAVLEEREDLQ--RPADLYLEGSDQ-------YrgWFNSslstaVAVTGKAPY-KGVLSHGFVLDgEGRKMSKSIGN 600
Cdd:PRK12300 513 IPKEILEEMREEFLywYPVDWRHSGKDLipnhltfF--IFNH-----VAIFPEEKWpRGIVVNGFVLL-EGKKMSKSKGN 584
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 601 IVVPKKIMDQLGGDILRLWV-SSVDYQSDVRISDDILKQVAEVYRKIRNTFRFLLGNLDDfkpsenavavAELREVDRYM 679
Cdd:PRK12300 585 VIPLRKAIEEYGADVVRLYLtSSAELLQDADWREKEVESVRRQLERFYELAKELIEIGGE----------EELRFIDKWL 654
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 680 LVKLNDLITKVKEAYETYDFAAVYhaihnfctidLSSFYlDFAKDI-LYIEGANHEDRRaiqtVLYDVLVALTKLVTPIL 758
Cdd:PRK12300 655 LSRLNRIIKETTEAMESFQTRDAV----------QEAFY-ELLNDLrWYLRRVGEANNK----VLREVLEIWIRLLAPFT 719
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 759 PHTADEVWPYIPGvtEESVQLTDMPEAVQLddaealktKWDAFMTLRDDVLKAL-EVARNEKVIGKSLNASITLYPTAEM 837
Cdd:PRK12300 720 PHLAEELWHKLGG--EGFVSLEKWPEPDES--------KIDEEAELAEEYVKRLiEDIREILKVAKIKPKKVYIYVAPDW 789
|
890 900 910
....*....|....*....|....*....|....*
gi 446378097 838 K---AMLESISEDLKQLF--IVSEYKLGGMMDEAP 867
Cdd:PRK12300 790 KyevLEIAAENGDVKEAIkeLMKDEELRKHGKEVA 824
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
676-831 |
4.80e-34 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 127.13 E-value: 4.80e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 676 DRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTIDLSSFYLDFAKDILYiegaNHEDRRAIQTVLYDVLVALTKLVT 755
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLY----GEEPDSRAQTTLYEVLETLLRLLA 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446378097 756 PILPHTADEVWpyipgvTEESVQLTDMPEAVQLDDAEalktkWDAFMTLRDDVLKALEVARNEKVIGKSLNASITL 831
Cdd:pfam08264 77 PFMPFITEELW------QKESIHLAPWPEDAELEEAE-----LEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
637-785 |
3.86e-27 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 109.18 E-value: 3.86e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 637 KQVAEVYRK----IRNTFRFLLG--NLDDFKPSENAVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFC 710
Cdd:cd07961 4 KGVREVVRKvllpLWNAYRFFVTyaNLDGFDPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFI 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446378097 711 tIDLSSFYLDFAKDILYIEGANHEDRRAIQTvLYDVLVALTKLVTPILPHTADEVW----PYIPGvTEESVQLTDMPEA 785
Cdd:cd07961 84 -DELTNWYIRRNRKRFWGEEGDDDKLAAYAT-LYEVLLTLSRLMAPFTPFITEEIYqnlrRELGD-APESVHLLDWPEV 159
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
638-766 |
1.04e-23 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 97.63 E-value: 1.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 638 QVAEVYR----KIRNTFRFLLGNLDDFKPSEnaVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTID 713
Cdd:cd07962 4 KRVEGGRnfcnKLWNAARFVLMNLEDDDEPE--EDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWND 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 446378097 714 LSSFYLDFAKDILYIEGAnhEDRRAIQTVLYDVLVALTKLVTPILPHTADEVW 766
Cdd:cd07962 82 FCDWYLELVKPRLYGEDE--EEKKAARATLYYVLETILRLLHPFMPFITEELW 132
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
57-766 |
1.77e-20 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 96.34 E-value: 1.77e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 57 PYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLPIEQALTNKGVkrkemTVAEFrklCAEYAyeqvERQR 136
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGI-----TPQEL---VDRIH----AEFK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 137 EQFKRLGVraDWDNpYI-TLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPtsesalaeaeieyqdkksasiyvafpvk 215
Cdd:COG0143 78 ELFEKLGI--SFDN-FIrTTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCP---------------------------- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 216 dgknvleGDEKYiiwtttpwtLPanlgisvhpeleysivkvndekyiiaselfetvaktlewenaevvktvkgseleytv 295
Cdd:COG0143 127 -------ECERF---------LP--------------------------------------------------------- 133
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 296 akhpfydrdslvmlgdhvttdagtgcvhtapghgeDDFVVGKkyglevlCPVddkgvltneaPGFEGLFYDKAnkpitek 375
Cdd:COG0143 134 -----------------------------------DRYVEGT-------CPK----------CGAEDAYGDQC------- 154
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 376 lEEVGALLKLTFITHsyPHDWRTKKPIIFRATAQWFASIEAFRKELIEAVAEtkwVPAWGETRLHNMVR--DRG--DWCI 451
Cdd:COG0143 155 -ENCGATLEPTELIN--PRSAISGAPPELREEEHYFFRLSKYQDRLLEWIEE---NPDIQPEVRNEVLSwlKEGlqDLSI 228
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 452 SRQRAWGVPIPvfyaenGDPiitdetiNHVadlfrehgsnvwfereakdllpegfthpgspngefrketdiMDVWFD--- 528
Cdd:COG0143 229 SRDFDWGIPVP------GDP-------GKV-----------------------------------------FYVWFDali 254
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 529 ---SgsshqAVLEEREDLQRPADlylegsdqYRGWFNSSLSTAVAVTGK-------------------APYKGVLSHGFV 586
Cdd:COG0143 255 gyiS-----ATKGYADDRGLPED--------FEKYWPAPDTELVHFIGKdiirfhaiiwpamlmaaglPLPKKVFAHGFL 321
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 587 LDgEGRKMSKSIGNIVVPKKIMDQLGGDILRLWVSS-VDYQSDVRISDDILKQV--AE--------VYRKIRNTFRFLLG 655
Cdd:COG0143 322 TV-EGEKMSKSRGNVIDPDDLLDRYGPDALRYYLLReVPFGQDGDFSWEDFVARvnSDlandlgnlASRTLSMIHKYFDG 400
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 656 NLDdfkpsenavAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFctIDLSSFYLD------FAKDilyie 729
Cdd:COG0143 401 KVP---------EPGELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMAL--ARAANKYIDetapwkLAKD----- 464
|
730 740 750 760
....*....|....*....|....*....|....*....|
gi 446378097 730 ganhEDRRAIQTVLY---DVLVALTKLVTPILPHTADEVW 766
Cdd:COG0143 465 ----EDPERLATVLYtllEALRILAILLKPFLPETAEKIL 500
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
57-794 |
3.00e-18 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 89.36 E-value: 3.00e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 57 PYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLPIEQALTNKGVKRKEmtvaefrkLCAEYayeqVERQR 136
Cdd:TIGR00398 8 PYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAEQEGLTPKE--------LVDKY----HEEFK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 137 EQFKRLGVraDWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAEaeieyqdkksasiyvaFPVKD 216
Cdd:TIGR00398 76 DDWKWLNI--SFDRFIRTTDEEHKEIVQKIFQKLKENGYIYEKEIKQLYCPECEMFLPD----------------RYVEG 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 217 GKNVLEGDEKYiiwtttpwtlpanlgisvhpeleysivkvndekyiiaSELFETVAKTLE-WENAEVVKTVKGSELEYTV 295
Cdd:TIGR00398 138 TCPKCGSEDAR-------------------------------------GDHCEVCGRHLEpTELINPRCKICGAKPELRD 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 296 AKHPFYDRDSLvmlgdhvttdagtgcvhtapghgeddfvvgkkyglevlcpvddkgvltneapgfeglfydkankpiTEK 375
Cdd:TIGR00398 181 SEHYFFRLSAF------------------------------------------------------------------EKE 194
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 376 LEEvgallkltfithsyphdWrTKKPIIFrataqwfasieafrKELIEAVAETkwVPAWGETRLHnmvrdrgDWCISRQR 455
Cdd:TIGR00398 195 LEE-----------------W-IRKNPES--------------GSPASNVKNK--AQNWLKGGLK-------DLAITRDL 233
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 456 A-WGVPIPvfyaenGDPiitdetiNHVAdlfrehgsNVWFEReakdllPEGFThpgSPNGEFRKETDIMDVWFDSGSSHQ 534
Cdd:TIGR00398 234 VyWGIPVP------NDP-------NKVV--------YVWFDA------LIGYI---SSLGILSGDTEDWKKWWNNDEDAE 283
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 535 AVLEEREDLQR------PAdlYLEGSdqyrGWfnsslstavavtgKAPyKGVLSHGFVLDgEGRKMSKSIGNIVVPKKIM 608
Cdd:TIGR00398 284 LIHFIGKDIVRfhtiywPA--MLMGL----GL-------------PLP-TQVFSHGYLTV-EGGKMSKSLGNVVDPSDLL 342
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 609 DQLGGDILRLW-VSSVDYQSDVRISDDILKQV--AE--------VYRKIRNTFRFLLGNLDDFKpsenavavaELREVDR 677
Cdd:TIGR00398 343 ARFGADILRYYlLKERPLGKDGDFSWEDFVERvnADlanklgnlLNRTLGFIKKYFNGVLPSED---------ITDEEDK 413
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 678 YMLVKLNDLITKVKEAYETYDF-AAVYHAIHnfcTIDLSSFYLDFAKDilyIEGANHEDR-RAIQTVLYDVLVALTKLVT 755
Cdd:TIGR00398 414 KLLKLINEALEQIDEAIESFEFrKALREIMK---LADRGNKYIDENKP---WELFKQSPRlKELLAVCSMLIRVLSILLY 487
|
730 740 750
....*....|....*....|....*....|....*....
gi 446378097 756 PILPHTADEVWPYIpGVTEESVQLTDMPEAVQLDDAEAL 794
Cdd:TIGR00398 488 PIMPKLSEKILKFL-NFELEWDFKLKLLEGHKLNKAEPL 525
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
57-185 |
4.01e-18 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 86.15 E-value: 4.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 57 PYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLPIEQALTNKGVKRKEMTvaefrklcaeyaYEQVERQR 136
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWT------------EYNIKKMK 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 446378097 137 EQFKRLGVRADWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYW 185
Cdd:cd00812 77 EQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNW 125
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
57-199 |
2.10e-17 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 85.42 E-value: 2.10e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 57 PYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLPIEQALTNKGVkrkemTVAEfrkLCAEYayeqVERQR 136
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGI-----TPEE---LVDRY----HEIHR 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446378097 137 EQFKRLGVraDWDNPYITLEPA-YEAQQiKVFGDMAKKGYIYKGQKPVYWSPTSESALAEAEIE 199
Cdd:pfam09334 76 EDFKKFNI--SFDDYGRTTSERhHELVQ-EFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVE 136
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
633-758 |
2.26e-16 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 76.01 E-value: 2.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 633 DDILKQVAEVYRKIRNTFRFLLGNLDDFKPSENAvavAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFCTI 712
Cdd:cd07375 1 EERLKQARAFLNRLYRLLSFFRKALGGTQPKWDN---ELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNE 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 446378097 713 DlsSFYLDFAKDILYIEganhEDRRAIQTVLYDVLVALTKLVTPIL 758
Cdd:cd07375 78 L--NWYLDELKPALQTE----ELREAVLAVLRAALVVLTKLLAPFT 117
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
57-195 |
1.16e-15 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 79.11 E-value: 1.16e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 57 PYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLPIEQALTNKGVKRKEmtvaefrkLCAEYAyeqvERQR 136
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQE--------LCDKYH----EIFK 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 446378097 137 EQFKRLGVraDWDNPYITLEPAYEAQQIKVFGDMAKKGYIYKGQKPVYWSPTSESALAE 195
Cdd:cd00814 77 DLFKWLNI--SFDYFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLPE 133
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
448-766 |
4.06e-13 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 72.99 E-value: 4.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 448 DWCISRQRA-WGVPIPvfyaenGDPiitdetiNHVadlfrehgsnvwfereakdllpegfthpgspngefrketdiMDVW 526
Cdd:PRK11893 200 DLSISRTNFdWGIPVP------GDP-------KHV-----------------------------------------IYVW 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 527 FDSGSSHQAVLEEREDLQR---------PADLYLEGSDQYRgwFNSSLSTAV--AVTGKAPyKGVLSHGFVLDgEGRKMS 595
Cdd:PRK11893 226 FDALTNYLTALGYPDDEELlaelfnkywPADVHLIGKDILR--FHAVYWPAFlmAAGLPLP-KRVFAHGFLTL-DGEKMS 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 596 KSIGNIVVPKKIMDQLGGDILRLWVSS-VDYQSDVRISDDILKQV--AEVYRKIRN----TFRFLLGNLDDFKPSenava 668
Cdd:PRK11893 302 KSLGNVIDPFDLVDEYGVDAVRYFLLReIPFGQDGDFSREAFINRinADLANDLGNlaqrTLSMIAKNFDGKVPE----- 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 669 VAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIhnfctIDLSSF---YLDfakdilyiEGA----NHEDRRAIQT 741
Cdd:PRK11893 377 PGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAI-----LALVRAankYID--------EQApwslAKTDPERLAT 443
|
330 340 350
....*....|....*....|....*....|
gi 446378097 742 VLYDVL-----VALtkLVTPILPHTADEVW 766
Cdd:PRK11893 444 VLYTLLevlrgIAV--LLQPVMPELAAKIL 471
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
57-178 |
5.18e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 63.25 E-value: 5.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 57 PYANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLPIEqaltnkgVKRKEMTVAEfRKLCAEYAyeqvERQR 136
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIM-------LKAEKEGITP-EELIARYH----AEHK 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 446378097 137 EQFKRLGVraDWDNPYITLEPA-YE-AQQIkvFGDMAKKGYIYK 178
Cdd:PRK00133 79 RDFAGFGI--SFDNYGSTHSEEnRElAQEI--YLKLKENGYIYE 118
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
58-179 |
1.53e-09 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 61.74 E-value: 1.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 58 YANGDIHMGHALNKVLKDFIVRYKSMTGFSAPYVPGWDTHGLPIEQALTNKGVKRKemtvaefrklcaEYAYEQVERQRE 137
Cdd:PRK12267 14 YPNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQ------------EYVDEISAGFKE 81
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 446378097 138 QFKRLGVRADwdnPYI-TLEPAYEAQQIKVFGDMAKKGYIYKG 179
Cdd:PRK12267 82 LWKKLDISYD---KFIrTTDERHKKVVQKIFEKLYEQGDIYKG 121
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
409-629 |
4.18e-09 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 59.18 E-value: 4.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 409 QWFASI--EAFRKELIEAVAETKWVPAwgETRlhNMVRDRGDwcISRQRAWGVPIPVfyaengdpiitdetinhvadlfr 486
Cdd:cd00812 131 QWFLKYseTEWKEKLLKDLEKLDGWPE--EVR--AMQENWIG--CSRQRYWGTPIPW----------------------- 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 487 ehgsnvwfereakdllpegfthpgspngefrkeTDIMDVWFDSG----------SSHQAVLEEREDLQR------PADLY 550
Cdd:cd00812 182 ---------------------------------TDTMESLSDSTwyyarytdahNLEQPYEGDLEFDREefeywyPVDIY 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 551 LEGSDQ-------YRgwFNSSLSTAVAVTGKAPYKGVLSHGFVLdGEGRKMSKSIGNIVVPKKIMDQLGGDILRLWV-SS 622
Cdd:cd00812 229 IGGKEHapnhllySR--FNHKALFDEGLVTDEPPKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAIKKYGADAARLYIlFA 305
|
....*..
gi 446378097 623 VDYQSDV 629
Cdd:cd00812 306 APPDADF 312
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
403-617 |
4.53e-09 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 59.08 E-value: 4.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 403 IFRATAQWFASIEAFRKELIEAVAETKwVPAWGETRlHNMVRDR-----GDWCISRQRA-WGVPIP-----VFYaengdp 471
Cdd:cd00814 133 EWREEEHYFFRLSKFQDRLLEWLEKNP-DFIWPENA-RNEVLSWlkeglKDLSITRDLFdWGIPVPldpgkVIY------ 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 472 iitdetinhvadlfrehgsnVWFereakDLLPEGFTHPGSPNGEFRKETDIMDVWfdsgsshqavleeredlqrPADLYL 551
Cdd:cd00814 205 --------------------VWF-----DALIGYISATGYYNEEWGNSWWWKDGW-------------------PELVHF 240
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446378097 552 EGSD------QYrgwFNSSLSTAvavtGKAPYKGVLSHGFVLDgEGRKMSKSIGNIVVPKKIMDQLGGDILR 617
Cdd:cd00814 241 IGKDiirfhaIY---WPAMLLGA----GLPLPTRIVAHGYLTV-EGKKMSKSRGNVVDPDDLLERYGADALR 304
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
583-674 |
1.19e-08 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 58.58 E-value: 1.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 583 HGFV-LDGEgrKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDVRISDDILKQVAEVYRKIRNTFRFLLGNLDdfK 661
Cdd:COG0215 256 NGFLtVNGE--KMSKSLGNFFTVRDLLKKYDPEVLRFFLLSAHYRSPLDFSEEALEEAEKALERLYNALRRLEEALG--A 331
|
90
....*....|...
gi 446378097 662 PSENAVAVAELRE 674
Cdd:COG0215 332 ADSSAEEIEELRE 344
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
204-377 |
2.80e-08 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 54.47 E-value: 2.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 204 KSASIYVAFPVKDGknvlegDEKYIIWTTTPWTLpanLGISvhpeleysivkvndekYI-IASE--LFETVAKTLEwENA 280
Cdd:pfam13603 6 RSEGAEITFPVEGT------DEKIEVFTTRPDTL---MGVT----------------FVaLAPEhpLVEKLAEKNP-EVA 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 281 EVVKTVKG-SELEYTVAK-------------HPFYDRDSLVMLGDHVTTDAGTGCVHTAPGHGEDDFVVGKKYGLE---V 343
Cdd:pfam13603 60 AFIEECKNtSEIERTSETkekegvftglyaiHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPikpV 139
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 446378097 344 LCPVD-------------DKGVLTNEAPgFEGLFYDKANKPITEKLE 377
Cdd:pfam13603 140 IQPEDgdldldimteaytEEGILVNSGE-FDGLDSEEAKEAIIKKLE 185
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
401-847 |
1.81e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 55.16 E-value: 1.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 401 PIIFRATAQWFASIEAFRKELIEavaetkwvpaWGETRLH------NMVR---DRG--DWCISRQRAW-GVPIP-----V 463
Cdd:PRK00133 178 TPVLKESEHFFFKLPRFEEFLKE----------WITRSGElqpnvaNKMKewlEEGlqDWDISRDAPYfGFEIPgapgkV 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 464 FYaengdpiitdetinhvadlfrehgsnVWFEreA--------KDLLPEgfthpgspngefRKETDIMDVWFDSGSS--- 532
Cdd:PRK00133 248 FY--------------------------VWLD--ApigyisstKNLCDK------------RGGLDWDEYWKKDSDTely 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 533 ---------HQAVLeeredlqRPAdlYLEGSDqYRgwfnssLSTAVAVtgkapykgvlsHGFvLDGEGRKMSKSIGNIVV 603
Cdd:PRK00133 288 hfigkdiiyFHTLF-------WPA--MLEGAG-YR------LPTNVFA-----------HGF-LTVEGAKMSKSRGTFIW 339
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 604 PKKIMDQLGGDILR--------LWVSSVDYQSDV---RISDDIL-KQVAEVYRKIRNTFRFLLGNLDDfkpsenavavae 671
Cdd:PRK00133 340 ARTYLDHLDPDYLRyylaaklpETIDDLDFNWEDfqqRVNSELVgKVVNFASRTAGFINKRFDGKLPD------------ 407
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 672 lREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIhnfctIDLSSF---YLD------FAKdilyieganhEDRRAIQTV 742
Cdd:PRK00133 408 -ALADPELLEEFEAAAEKIAEAYEAREFRKALREI-----MALADFankYVDdnepwkLAK----------QDGERLQAV 471
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 743 LYDVLV---ALTKLVTPILPHTADEVWPYIpGVTEESVQLTDMPEAV-QLDDAEALKTKWDafmtlrDDVLKALEVARNE 818
Cdd:PRK00133 472 CSVGLNlfrALAIYLKPVLPELAERAEAFL-NLEELTWDDAQQPLAGhPINKFKILFTRIE------DKQIEALIEASKE 544
|
490 500
....*....|....*....|....*....
gi 446378097 819 KVIGKSLNASITlyPTAEMKAMLESISED 847
Cdd:PRK00133 545 AAAAKAAAAAAA--APLAEEPIAETISFD 571
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
663-766 |
2.18e-07 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 50.28 E-value: 2.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 663 SENAVAVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIhnfctidlssFYlDFAKDI-LYIEGANHEDRRAiqt 741
Cdd:cd07959 24 IETEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEG----------LY-ELQNDLdWYRERGGAGMNKD--- 89
|
90 100
....*....|....*....|....*
gi 446378097 742 VLYDVLVALTKLVTPILPHTADEVW 766
Cdd:cd07959 90 LLRRFIEVWTRLLAPFAPHLAEEIW 114
|
|
| zf-FPG_IleRS |
pfam06827 |
Zinc finger found in FPG and IleRS; This zinc binding domain is found at the C-terminus of ... |
885-912 |
1.28e-06 |
|
Zinc finger found in FPG and IleRS; This zinc binding domain is found at the C-terminus of isoleucyl tRNA synthetase and the enzyme Formamidopyrimidine-DNA glycosylase EC:3.2.2.23.
Pssm-ID: 429140 [Multi-domain] Cd Length: 28 Bit Score: 45.27 E-value: 1.28e-06
10 20
....*....|....*....|....*...
gi 446378097 885 GETCERCWVVSETIGKDAEHETLCERCA 912
Cdd:pfam06827 1 GEKCPRCWTYIEKVGVGGRSTYFCPRCQ 28
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
576-766 |
1.95e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 51.72 E-value: 1.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 576 PYKGVLSHGFVLdGEGRKMSKSIGNIVVPKKIMDQLGGDILRLW-VSSVDYQSDVRISDDILKQvaevyrkirntfRF-- 652
Cdd:PRK12267 283 LPKKVFAHGWWL-MKDGKMSKSKGNVVDPEELVDRYGLDALRYYlLREVPFGSDGDFSPEALVE------------RIns 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 653 -L---LGNLDD------FKPSENAV-AVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIHNFctIDLSSFYLD- 720
Cdd:PRK12267 350 dLandLGNLLNrtvamiNKYFDGEIpAPGNVTEFDEELIALAEETLKNYEELMEELQFSRALEEVWKL--ISRANKYIDe 427
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 446378097 721 -----FAKDilyieganHEDRRAIQTVLYDVLVALTK---LVTPILPHTADEVW 766
Cdd:PRK12267 428 tapwvLAKD--------EGKKERLATVMYHLAESLRKvavLLSPFMPETSKKIF 473
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
485-775 |
1.66e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 48.56 E-value: 1.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 485 FREHGSNVWFEREAKDL-LPEGFTHPGSPNGEFRKETdiMDVWFDSGSSHQAVLEEREDLQR---------PADLYLEGS 554
Cdd:PLN02224 252 YRLNEVQSWIKSGLRDFsISRALVDWGIPVPDDDKQT--IYVWFDALLGYISALTEDNKQQNletavsfgwPASLHLIGK 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 555 DQYRgwFNSSLSTAVAVT-GKAPYKGVLSHGFvLDGEGRKMSKSIGNIVVPKKIMDQLGGDILR-LWVSSVDYQSDVRIS 632
Cdd:PLN02224 330 DILR--FHAVYWPAMLMSaGLELPKMVFGHGF-LTKDGMKMGKSLGNTLEPFELVQKFGPDAVRyFFLREVEFGNDGDYS 406
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 633 DDILKQV--AEVYRKIRNTFRFLLGNLDdfKPSENAVAVAELREVDRYMLV-KLNDLITKVKEAYETYDFAAVYHAIHNF 709
Cdd:PLN02224 407 EDRFIKIvnAHLANTIGNLLNRTLGLLK--KNCESTLVEDSTVAAEGVPLKdTVEKLVEKAQTNYENLSLSSACEAVLEI 484
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446378097 710 CtiDLSSFYLD-FAKDILYIEGA-NHEDRRAIQTVLYDVLVALTKLVTPILPHTADEVWPYIpGVTEE 775
Cdd:PLN02224 485 G--NAGNTYMDqRAPWFLFKQGGvSAEEAAKDLVIILEVMRVIAVALSPIAPCLSLRIYSQL-GYSED 549
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
654-766 |
2.81e-05 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 44.40 E-value: 2.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 654 LGNL-----------DDFKPSEnavaVAELREVDRYMLVKLNDLITKVKEAYETYDFAAVYHAIhnfctIDLSSF---YL 719
Cdd:cd07957 9 LGNLvnrtlnmaskyFGGVVPE----FGGLTEEDEELLEEAEELLEEVAEAMEELEFRKALEEI-----MELARAankYI 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 446378097 720 DFAKD-ILyiegANHEDRRAIQTVLYDVL---VALTKLVTPILPHTADEVW 766
Cdd:cd07957 80 DETAPwKL----AKEEDPERLATVLYVLLellRILAILLSPFMPETAEKIL 126
|
|
| cysS |
PRK14535 |
cysteinyl-tRNA synthetase; Provisional |
581-701 |
2.65e-03 |
|
cysteinyl-tRNA synthetase; Provisional
Pssm-ID: 173001 [Multi-domain] Cd Length: 699 Bit Score: 41.63 E-value: 2.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378097 581 LSHGFV-LDGEgrKMSKSIGNIVVPKKIMDQLGGDILRLWVSSVDYQSDVRIS----DDILKQVAEVYRKIRNTfrfllg 655
Cdd:PRK14535 497 LHNGFIrVDGE--KMSKSLGNFFTIREVLKQYDPEVVRFFILRAHYRSPLNYSdahlDDAKGALTRLYTTLKNT------ 568
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 446378097 656 NLDDFKPSENAvavaelREVDRYMLVKLNDLITKVKEAYETYDFAA 701
Cdd:PRK14535 569 PAAEFMLSENV------NDYTRRFYAAMNDDFGTVEAVAVLFELAG 608
|
|
| |
