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Conserved domains on  [gi|446378628|ref|WP_000456483|]
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MULTISPECIES: GyrI-like domain-containing protein [Staphylococcus]

Protein Classification

GyrI-like domain-containing protein( domain architecture ID 10007857)

GyrI-like domain-containing protein adopts a beta-barrel fold similar to the effector-binding region of AraC/XylS transcription activators and may bind a small molecule

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YdeE COG3708
Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription] ...
1-156 9.41e-35

Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription];


:

Pssm-ID: 442922  Cd Length: 157  Bit Score: 118.59  E-value: 9.41e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378628   1 MEYQLQQLASLMLVGIKETYEN-GRQAQQHIAGFWQRCYQEGVLadlQLKNNGDLAGILGLCIPEL--DGKMSYMIAVAG 77
Cdd:COG3708    1 MEYRIVEKPAFKLVGLSARTSNsDEEANEEIPALWQRFLPEGLA---EIPNLSNPGGLYGVCTDYEsdEGEFDYLAGVEV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378628  78 DNSDDI-EKYDVITLASSKYMVFEAQGAVPKAVQqkmeEVHHYIHQ-------YQADKvksAPFFELYQDGDTTSEKYIT 149
Cdd:COG3708   78 SSFDEVpEGLETLEIPAGTYAVFTHKGPMPEALQ----ETWQYIYSewlpssgYERAD---GPDFEVYDERDDPSPDSEV 150

                 ....*..
gi 446378628 150 EIWMPVK 156
Cdd:COG3708  151 EIWIPIK 157
 
Name Accession Description Interval E-value
YdeE COG3708
Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription] ...
1-156 9.41e-35

Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription];


Pssm-ID: 442922  Cd Length: 157  Bit Score: 118.59  E-value: 9.41e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378628   1 MEYQLQQLASLMLVGIKETYEN-GRQAQQHIAGFWQRCYQEGVLadlQLKNNGDLAGILGLCIPEL--DGKMSYMIAVAG 77
Cdd:COG3708    1 MEYRIVEKPAFKLVGLSARTSNsDEEANEEIPALWQRFLPEGLA---EIPNLSNPGGLYGVCTDYEsdEGEFDYLAGVEV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378628  78 DNSDDI-EKYDVITLASSKYMVFEAQGAVPKAVQqkmeEVHHYIHQ-------YQADKvksAPFFELYQDGDTTSEKYIT 149
Cdd:COG3708   78 SSFDEVpEGLETLEIPAGTYAVFTHKGPMPEALQ----ETWQYIYSewlpssgYERAD---GPDFEVYDERDDPSPDSEV 150

                 ....*..
gi 446378628 150 EIWMPVK 156
Cdd:COG3708  151 EIWIPIK 157
AraC_E_bind smart00871
Bacterial transcription activator, effector binding domain; This domain is found in the ...
2-156 1.22e-23

Bacterial transcription activator, effector binding domain; This domain is found in the probable effector binding domain of a number of different bacterial transcription activators.and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.


Pssm-ID: 214874 [Multi-domain]  Cd Length: 158  Bit Score: 90.23  E-value: 1.22e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378628     2 EYQLQQLASLMLVGIKETYENGRQAqqhIAGFWQRCYQEGVLADLQL-KNNGDLAGILGLCIP-ELDGKMSYMIAVAGDN 79
Cdd:smart00871   1 EVRIVELPAFKVAGLRHRGPNEDEK---IPELWQRLIQWAKELGLLPvGNSGEPYGVYYDDPDdTPDGEFRYDAGVEVSD 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378628    80 SDDI-EKYDVITLASSKYMVFEAQGAVPKAVQQKMEEVHHYIHQ---YQADkvKSAPFFELYQDG--DTTSEKYITEIWM 153
Cdd:smart00871  78 EVEApEGVETKTIPAGKYAVFTHKGGSYDEIQEAWEAIYGEWLPnsgYELR--DAGPDFEVYLNDppDTDPEELVTEIYI 155

                   ...
gi 446378628   154 PVK 156
Cdd:smart00871 156 PVK 158
GyrI-like pfam06445
GyrI-like small molecule binding domain; This family contains the small molecule binding ...
2-155 8.93e-09

GyrI-like small molecule binding domain; This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.


Pssm-ID: 428947  Cd Length: 153  Bit Score: 51.26  E-value: 8.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378628    2 EYQLQQLASLMLVGIKETYENGRQaqqHIAGFWQRCYQEGVLADLQLKNNGdlagILGLCI--PEL--DGKMSYMIAVA- 76
Cdd:pfam06445   1 EVEIVELPAFRVAGLRHRGPYNEE---GIGALWEELCAWASENGLSPAPSP----LIGVSYddPEVteDEELRYDAGVAv 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378628   77 GDNSDDIEKYDVITLASSKYMVFEAQGAvPKAVQQKMEEVHHYI---HQYQADkvkSAPFFELY--QDGDTTSEKYITEI 151
Cdd:pfam06445  74 PIPVEGPEGVEELELPGGEYAVFRHKGP-YDDLQETYAKIYGEWlpeSGYERR---DGPSFEIYlnDPREVPEEELKTEI 149

                  ....
gi 446378628  152 WMPV 155
Cdd:pfam06445 150 YIPV 153
 
Name Accession Description Interval E-value
YdeE COG3708
Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription] ...
1-156 9.41e-35

Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription];


Pssm-ID: 442922  Cd Length: 157  Bit Score: 118.59  E-value: 9.41e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378628   1 MEYQLQQLASLMLVGIKETYEN-GRQAQQHIAGFWQRCYQEGVLadlQLKNNGDLAGILGLCIPEL--DGKMSYMIAVAG 77
Cdd:COG3708    1 MEYRIVEKPAFKLVGLSARTSNsDEEANEEIPALWQRFLPEGLA---EIPNLSNPGGLYGVCTDYEsdEGEFDYLAGVEV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378628  78 DNSDDI-EKYDVITLASSKYMVFEAQGAVPKAVQqkmeEVHHYIHQ-------YQADKvksAPFFELYQDGDTTSEKYIT 149
Cdd:COG3708   78 SSFDEVpEGLETLEIPAGTYAVFTHKGPMPEALQ----ETWQYIYSewlpssgYERAD---GPDFEVYDERDDPSPDSEV 150

                 ....*..
gi 446378628 150 EIWMPVK 156
Cdd:COG3708  151 EIWIPIK 157
AraC_E_bind smart00871
Bacterial transcription activator, effector binding domain; This domain is found in the ...
2-156 1.22e-23

Bacterial transcription activator, effector binding domain; This domain is found in the probable effector binding domain of a number of different bacterial transcription activators.and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.


Pssm-ID: 214874 [Multi-domain]  Cd Length: 158  Bit Score: 90.23  E-value: 1.22e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378628     2 EYQLQQLASLMLVGIKETYENGRQAqqhIAGFWQRCYQEGVLADLQL-KNNGDLAGILGLCIP-ELDGKMSYMIAVAGDN 79
Cdd:smart00871   1 EVRIVELPAFKVAGLRHRGPNEDEK---IPELWQRLIQWAKELGLLPvGNSGEPYGVYYDDPDdTPDGEFRYDAGVEVSD 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378628    80 SDDI-EKYDVITLASSKYMVFEAQGAVPKAVQQKMEEVHHYIHQ---YQADkvKSAPFFELYQDG--DTTSEKYITEIWM 153
Cdd:smart00871  78 EVEApEGVETKTIPAGKYAVFTHKGGSYDEIQEAWEAIYGEWLPnsgYELR--DAGPDFEVYLNDppDTDPEELVTEIYI 155

                   ...
gi 446378628   154 PVK 156
Cdd:smart00871 156 PVK 158
GyrI-like pfam06445
GyrI-like small molecule binding domain; This family contains the small molecule binding ...
2-155 8.93e-09

GyrI-like small molecule binding domain; This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.


Pssm-ID: 428947  Cd Length: 153  Bit Score: 51.26  E-value: 8.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378628    2 EYQLQQLASLMLVGIKETYENGRQaqqHIAGFWQRCYQEGVLADLQLKNNGdlagILGLCI--PEL--DGKMSYMIAVA- 76
Cdd:pfam06445   1 EVEIVELPAFRVAGLRHRGPYNEE---GIGALWEELCAWASENGLSPAPSP----LIGVSYddPEVteDEELRYDAGVAv 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378628   77 GDNSDDIEKYDVITLASSKYMVFEAQGAvPKAVQQKMEEVHHYI---HQYQADkvkSAPFFELY--QDGDTTSEKYITEI 151
Cdd:pfam06445  74 PIPVEGPEGVEELELPGGEYAVFRHKGP-YDDLQETYAKIYGEWlpeSGYERR---DGPSFEIYlnDPREVPEEELKTEI 149

                  ....
gi 446378628  152 WMPV 155
Cdd:pfam06445 150 YIPV 153
Cass2 pfam14526
Integron-associated effector binding protein; This family contains Cass2 from Vibrio cholerae, ...
13-155 6.67e-08

Integron-associated effector binding protein; This family contains Cass2 from Vibrio cholerae, an integron-associated protein that has been shown to bind cationic drug compounds with submicromolar affinity. Cass2 has been proposed to be representative of a larger family of independent effector-binding proteins associated with lateral gene transfer within Vibrio and other closely-related species.


Pssm-ID: 434016 [Multi-domain]  Cd Length: 149  Bit Score: 48.89  E-value: 6.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446378628   13 LVGIK-ETYENGRQAQQHIAGFWQRCYQEGVLADLqlKNNGDLAGILGLCIPElDGKMSYMIAVAGDNSDDI-EKYDVIT 90
Cdd:pfam14526  10 VAGIRyEGPNEYEDHNKEIGKFWEEFNEDGRLPNI--KKDDKSYGIYVDYEDE-ENEFDYYAGVEVPSFSELpEGLVVIE 86
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446378628   91 LASSKYMVFEAQGAVPKAVQQKMEEVHHYIHQYQADKVKSAPFFELYQDGDttSEKYITEIWMPV 155
Cdd:pfam14526  87 IPGGKYAVFTIEGDFPDAIAEAWTRIYGWLLPNSGYERAGGPDFEVYKENG--DENMKIELYIPV 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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