|
Name |
Accession |
Description |
Interval |
E-value |
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
1-422 |
0e+00 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 808.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 1 MFALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQMRLEKKIHVFSSNYALYHSM 80
Cdd:PRK03609 1 MFALCDVNSFYASCETVFRPDLRGKPVVVLSNNDGCVIARSAEAKALGIKMGDPWFKQKDLFRRCGVVCFSSNYELYADM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 81 SQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEIFGHQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQW-PQF 159
Cdd:PRK03609 81 SNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWqRQT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 160 SGVVALTaeNRNRTLKLLGLQPVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLE 239
Cdd:PRK03609 161 GGVVDLS--NLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFNVVLERTVRELRGEPCLSLE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 240 EAPPAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAVKEPCYSNAAVEKLPLPTQD 319
Cdd:PRK03609 239 EFAPTKQEIVCSRSFGERITDYESMRQAICSYAARAAEKLRGEHQYCRFISTFVKTSPFALNEPYYGNSASVKLLTPTQD 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 320 SRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQPGLFDEIQPRKNSEKLMKTLDELN-QSGKGKVWFAGRGTAP 398
Cdd:PRK03609 319 SRDIIAAATRALDAIWRDGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEQLMKVLDTLNaKSGKGTLYFAGQGIAQ 398
|
410 420
....*....|....*....|....
gi 446379660 399 EWQMKREMLSPAYTTRWTDLPVAQ 422
Cdd:PRK03609 399 QWQMKREMLSPRYTTRWSDLLRVK 422
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
3-350 |
0e+00 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 528.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 3 ALADINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIARSPEAKALGIRMGQPWFQVRQMRLEKKIHVFSSNYALYHSMSQ 82
Cdd:cd01700 1 ALVDCNSFYASCERVFRPLLLGRPLVVLSNNDGCVIARSPEAKALGIKMGSPYFKVPDLLERHGVAVFSSNYALYGDMSR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 83 RVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEIFGHQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQWPQFSGV 162
Cdd:cd01700 81 RIMSILERFSPDVEVYSIDESFLDLTGSLRFGDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLAKKKNPYGGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 163 VALTAENRNRtlKLLGLQPVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEEAP 242
Cdd:cd01700 161 VDLTDEEVRD--KLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLEEYP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 243 PAKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAVKEPCYSNAAVekLPLPTQDSRD 322
Cdd:cd01700 239 PPKKSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTSGFSRQPKYYSATNT--LPYPTNDTRE 316
|
330 340
....*....|....*....|....*...
gi 446379660 323 IIAAACRALNHVWREGYRYMKAGVMLAD 350
Cdd:cd01700 317 IVKAALRLLYAIYRPGYAYRKAGVMLSD 344
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
1-348 |
1.62e-134 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 389.50 E-value: 1.62e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 1 MFALADINSFYASCEKVFRPDLRNEPVIVLS-NNDGCVIARSPEAKALGIRMGQPWFQVRqmRLEKKIHVFSSNYALYHS 79
Cdd:COG0389 2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGdNNRGVVAAASYEARAFGVRSGMPLFQAR--RLCPDLVVLPPDFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 80 MSQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCI-SPEIFGHQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQwpq 158
Cdd:COG0389 80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFgSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKP--- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 159 fSGVVALTAENRNRTLKLLglqPVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISL 238
Cdd:COG0389 157 -DGLTVIPPGEVAAFLAPL---PVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 239 EEAPPAKqQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAVkepcysNAAVEKLPLPTQ 318
Cdd:COG0389 233 EPRRPRK-SIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRT------TTRSRTLPEPTD 305
|
330 340 350
....*....|....*....|....*....|
gi 446379660 319 DSRDIIAAACRALNHVWREGYRYMKAGVML 348
Cdd:COG0389 306 DTAELLRAARELLERIYRPGRPVRLLGVRL 335
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
6-337 |
8.90e-63 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 205.45 E-value: 8.90e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 6 DINSFYASCEKVFRPDLRNEPVIVLSNNDGCVIAR-SPEAKALGIRMGQPWFQVRqmRLEKKIHVFSSNYALYHSMSQRV 84
Cdd:cd03586 4 DMDAFYASVEQRDNPELKGKPVAVGGSSDRGVVSTaSYEARKFGVRSAMPIFQAK--KLCPNLIFVPPRFDKYREVSRQI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 85 MAVLESLSPAVEPYSIDEMFIDLRGINHCI-SPEIFGHQLREQVKSWTGLTMGVGIAPTKTLAKSA-QWAtKqwPqfSGV 162
Cdd:cd03586 82 MEILREYTPLVEPLSIDEAYLDVTDYVRLFgSATEIAKEIRARIREETGLTASAGIAPNKFLAKIAsDLN-K--P--NGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 163 VALTAENrnrTLKLLGLQPVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCISLEEAP 242
Cdd:cd03586 157 TVIPPED---VEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 243 PAKqQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAVkepcYSNAavEKLPLPTQDSRD 322
Cdd:cd03586 234 ERK-SIGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFST----RTRS--RTLPEPTDDAED 306
|
330
....*....|....*
gi 446379660 323 IIAAACRALNHVWRE 337
Cdd:cd03586 307 IYELALELLEELLDG 321
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
6-348 |
1.76e-54 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 184.10 E-value: 1.76e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 6 DINSFYASCEKVFRPDLRNEPVIVLSNND--GCVIARSPEAKALGIRMGQPWFQVRqmRLEKKIHVFSSNYALYHSMSQR 83
Cdd:cd00424 4 DFDNFFASVEQLARPELKGRPVVVVPFNSdsTCVIACSYEARKYGVKRGMPVREAR--KMCPNLILVPARLDLYRRLSER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 84 VMAVLESLSPAVEPYSIDEMFIDLRGINHCI-SPEIFGHQLREQVKSWTG-LTMGVGIAPTKTLAKSAqwATKQWPqfSG 161
Cdd:cd00424 82 LLSELEEVAPLVEVASIDELFLDLTGSARLLgLGSEVALRIKRHIAEQLGgITASIGIASNKLLAKLA--AKYAKP--DG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 162 VVALTAENRNRTLKLLglqPVGEVWGVGRRLTEKLNALGINTALQLAQANT-AFIRKNFSVILERTVRELNGESCISLEE 240
Cdd:cd00424 158 LTILDPEDLPGFLSKL---PLTDLPGIGAVTAKRLEAVGINPIGDLLAASPdALLALWGGVSGERLWYALRGIDDEPLSP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 241 APPaKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRT--SPFAVKEPCYSNAAVekLPLPTQ 318
Cdd:cd00424 235 PRP-RKSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTvdGRWSGHADIPSRSAP--RPISTE 311
|
330 340 350
....*....|....*....|....*....|..
gi 446379660 319 DsRDIIAAACRALNHVW--REGYRYMKAGVML 348
Cdd:cd00424 312 D-GELLHALDKLWRALLddKGPRRLRRLGVRL 342
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
4-383 |
2.28e-52 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 180.58 E-value: 2.28e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 4 LADINSFYASCEKVFRPDLRNEPVIVL---SNNDGCVIARSPEAKALGIRMGQPWFQVRQmrLEKKIHVFSSNYALYHSM 80
Cdd:PRK03103 7 LVDMQSFYASVEKAANPELKGRPVIVSgdpERRSGVVLAACPLAKAYGVKTAERLWEAQQ--KCPDLVVVKPRMQRYIDV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 81 SQRVMAVLESLSPAVEPYSIDEMFIDLRGINHCI-SPEIFGHQLREQVKSWTGLTMGVGIAPTKTLAKSA--QWAtKQWP 157
Cdd:PRK03103 85 SLQITRILEDFTDLVEPFSIDEQFLDVTGSQKLFgSPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMAcdNFA-KKNP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 158 qfSGVVALTAENRNRTLKLLglqPVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSV---ILERTVrelNGes 234
Cdd:PRK03103 164 --DGLFTLDKEDVPADLWPL---PVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGIngeVLWRTA---NG-- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 235 cisLEEAPPAKQQIVCSRSFGERIT------DKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAvkEPCYSNA 308
Cdd:PRK03103 234 ---IDYSPVTPHSLDRQKAIGHQMTlprdyrGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFD--WPTGFSR 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446379660 309 AVeKLPLPTQDSRDIIAAACRALNHVWrEGYRYMKAGVMLADFTPSGIAQPGLFDEiqpRKNSEKLMKTLDELNQ 383
Cdd:PRK03103 309 QM-TLPEPTNLAMEVYEAACKLFHRHW-DGKPVRRVGVTLSNLVSDDVWQLSLFGD---RERKRSLGYVMDDIKN 378
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
6-149 |
1.43e-45 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 154.65 E-value: 1.43e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 6 DINSFYASCEKVFRPDLRNEPVIVLSNN-DGCVIARSPEAKALGIRMGQPWFQVRqmRLEKKIHVFSSNYALYHSMSQRV 84
Cdd:pfam00817 2 DMDAFFASVELLRDPELKGKPVAVGGGNgRGIVAAASYEARKYGVRSGMPVFEAK--KLCPNLIVVPPDLELYRRASRKI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446379660 85 MAVLESL-SPAVEPYSIDEMFIDLRGINHCI-SPEIFGHQLREQVKSWTGLTMGVGIAPTKTLAKSA 149
Cdd:pfam00817 80 FEILRRFsTPKVEQASIDEAFLDLTGLEKLFgAEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLA 146
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
6-331 |
1.37e-40 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 147.48 E-value: 1.37e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 6 DINSFYASCEKVFRPDLRNEPVIVLSNND-----GCVIARSPEAKALGIRMGQPwfqvrqMRLE-KKI--HVF-SSNYAL 76
Cdd:PRK03352 11 DLDQFIAAVELLRRPELAGLPVIVGGNGDpteprKVVTCASYEARAFGVRAGMP------LRTAaRRCpdAVFlPSDPAA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 77 YHSMSQRVMAVLESLSPAVEPYSIDEMFIDLRGINhcisPEIFGHQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKqw 156
Cdd:PRK03352 85 YDAASEEVMATLRDLGVPVEVWGWDEAFLGVDTDD----PEALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAK-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 157 PQfsGVVALTAENrnrTLKLLGLQPVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVREL---NGE 233
Cdd:PRK03352 159 PA--GVFRLTDAN---WMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGPTTGPWLLLLargGGD 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 234 SCISLEEAPPAkqqivcSRS----FGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFavkepcYSNAA 309
Cdd:PRK03352 234 TEVSAEPWVPR------SRSrevtFPQDLTDRAEVESAVRELARRVLDEVVAEGRPVTRVAVKVRTATF------YTRTK 301
|
330 340
....*....|....*....|..
gi 446379660 310 VEKLPLPTQDSRDIIAAACRAL 331
Cdd:PRK03352 302 IRKLPEPTTDPDVIEAAALDVL 323
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
6-383 |
3.79e-40 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 147.87 E-value: 3.79e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 6 DINSFYASCEKVFRPDLRNEPVIVLSN---NDGCVIARSPEAKALGIRMGQPWFQVRqmRLEKKIHVFSSNYALYHSMSQ 82
Cdd:PRK01810 11 DMNSFFASVEIAYDPSLQGKPLAVAGNekeRKGIIVTCSYEARAYGIRTTMPLWEAK--RLCPQLIVRRPNFDRYREASR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 83 RVMAVLESLSPAVEPYSIDEMFIDLRGINHCISPEIFGHQLREQVKSWTGLTMGVGIAPTKTLAKSAQwatkQWPQFSGV 162
Cdd:PRK01810 89 QMFQILSEFTPLVQPVSIDEGYLDITDCYALGSPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMAS----DMKKPLGI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 163 VALtaenRNRTL-KLLGLQPVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGEscislEEA 241
Cdd:PRK01810 165 TVL----RKRDVpEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGI-----DDR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 242 PPAKQQIVCSRSFG------ERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFavKEPCYSnaavEKLPL 315
Cdd:PRK01810 236 PVDPEAIYQFKSVGnsttlsHDMDEEKELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDR--RTITRS----KTLKN 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 316 PTQDSRDIIAAACRALNHVWREG-YRYMK-AGVMLADFTPSGiAQPGLFDEIQPRKNsEKLMKTLDELNQ 383
Cdd:PRK01810 310 PIWEKRDIFQAASRLFKQHWNGDpVRLLGvTATDLEWKTEAV-KQLDLFSFEEDAKE-EPLLAVIDQIND 377
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
6-331 |
1.77e-36 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 138.91 E-value: 1.77e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 6 DINSFYASCEKVFRPDLRNEPVIV--LSNNdGCVIARSPEAKALGIRMGQPWFQVRqmRLEKKIHVF-SSNYALYHSMSQ 82
Cdd:PRK03348 11 DMDAFFASVEQLTRPTLRGRPVLVggLGGR-GVVAGASYEARVFGARSAMPMHQAR--RLVGNGAVVlPPRFVVYRAASR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 83 RVMAVLESLSPAVEPYSIDEMFID---LRGINhciSPEI--FGHQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKqwP 157
Cdd:PRK03348 88 RVFDTLRELSPVVEQLSFDEAFVEpaeLAGAS---AEEVeaFAERLRARVREETGLPASVGAGSGKQIAKIASGLAK--P 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 158 QFSGVVALTAEnrnrtLKLLGLQPVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKnfsvILERTVrelnGESCIS 237
Cdd:PRK03348 163 DGIRVVPPGEE-----RELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEVAN----LLGATV----GPALHR 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 238 L---------EEAPPAKqQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAVkepcYSNA 308
Cdd:PRK03348 230 LargiddrpvAERAEAK-QISAESTFAVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFST----LTRS 304
|
330 340
....*....|....*....|...
gi 446379660 309 AVekLPLPTQDSRDIIAAACRAL 331
Cdd:PRK03348 305 AT--LPYATDDAAVLAATARRLL 325
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
5-331 |
1.22e-35 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 135.50 E-value: 1.22e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 5 ADINSFYASCEKVFRPDLRNEPVIVlsnNDGCVIARSPEAKALGIRMGQPWFQVRqmRLEKKIHVFSSNYALYHSMSQRV 84
Cdd:PRK03858 9 ADLDSFYASVEQRDDPALRGRPVIV---GGGVVLAASYEAKAYGVRTAMGGRQAR--RLCPQAVVVPPRMSAYSRASKAV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 85 MAVLESLSPAVEPYSIDEMFIDLRGINHcIS--PEIFGHQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKqwPqfSGV 162
Cdd:PRK03858 84 FEVFRDTTPLVEGLSIDEAFLDVGGLRR-ISgtPVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAK--P--DGL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 163 VALTAEnrnRTLKLLGLQPVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKnfsvILERTV-RELngeSCISLEEA 241
Cdd:PRK03858 159 LVVPPD---RELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAELPESALVS----LLGPAAgRHL---HALAHNRD 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 242 PPA------KQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFavkepcysnAAVEK--- 312
Cdd:PRK03858 229 PRRvetgrrRRSVGAQRALGRGPNSPAEVDAVVVALVDRVARRMRAAGRTGRTVVLRLRFDDF---------TRATRsht 299
|
330
....*....|....*....
gi 446379660 313 LPLPTqDSRDIIAAACRAL 331
Cdd:PRK03858 300 LPRPT-ASTATLLAAARDL 317
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
6-362 |
6.66e-33 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 126.76 E-value: 6.66e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 6 DINSFYASCEKVFRPDLRNEPVIV--LSNNdGCVIARSPEAKALGIRMGQPWFQVRQmRLEKKIHVfSSNYALYHSMSQR 83
Cdd:PRK14133 9 DMDAFFASVEQMDNPKLKGKPVIVggISER-GVVSTCSYEARKYGVHSAMPVFMAKK-RCPHGIFL-PVRHERYKEVSKN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 84 VMAVLESLSPAVEPYSIDEMFIDLRGINHciSPEIFGHQLREQVKSWTGLTMGVGIAPTKTLAKSAQwatkQWPQFSGVV 163
Cdd:PRK14133 86 IFKILYEVTPIVEPVSIDEAYLDITNIKE--EPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLAS----DWNKPDGIK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 164 ALTAENRNRTLKLLglqPVGEVWGVGRRLTEKLNALGINTA---LQLAQAN-TAFIRKNFSVILERtVRELNGESCISLE 239
Cdd:PRK14133 160 IITEDMIPDILKPL---PISKVHGIGKKSVEKLNNIGIYTIedlLKLSREFlIEYFGKFGVEIYER-IRGIDYREVEVSR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 240 EappaKQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAVKEpcySNAAVEKLplpTQD 319
Cdd:PRK14133 236 E----RKSIGKETTLKKDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQTHT---KSKTLNDY---IRD 305
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 446379660 320 SRDIIAAACRALNHVWREGYRYMkAGVMLADFTPSGIAQPGLF 362
Cdd:PRK14133 306 KEEIYNVACEILEHINIKEPIRL-IGLSVSNLSENKIEQLSFL 347
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
6-368 |
1.25e-30 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 121.96 E-value: 1.25e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 6 DINSFYASCEKVFRPDLRNEPVIVLSNNDG-----CVIARSpeakaLGIRMGQPWFQVRQMRLEKKihVFSSNYALYHSM 80
Cdd:PRK02794 42 DCDAFYASVEKRDNPELRDKPVIIGGGKRGvvstaCYIARI-----HGVRSAMPMFKALKLCPDAV--VIKPDMEKYVRV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 81 SQRVMAVLESLSPAVEPYSIDEMFIDLRGIN--HCISPEIFGHQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKqwPQ 158
Cdd:PRK02794 115 GREVRAMMQALTPLVEPLSIDEAFLDLSGTErlHGAPPAVVLARFARRVEREIGITVSVGLSYNKFLAKIASDLDK--PR 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 159 -FSgVVAltaenRNRTLKLLGLQPVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGESCIS 237
Cdd:PRK02794 193 gFS-VIG-----RAEALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLARGIDDRK 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 238 LEEAPPAKqQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAVKepcysnAAVEKLPLPT 317
Cdd:PRK02794 267 VSPDREAK-SVSAETTFETDLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLR------TRRRTLEDPT 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446379660 318 QdSRDIIAAACRALNHVWREGYRYMKAGVMLADFTPSGIAQPG-LFDEIQPR 368
Cdd:PRK02794 340 Q-LADRIFRTARELLEKETDGTAFRLIGIGVSDLSPADEADPPdLLDPQATR 390
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
245-355 |
4.12e-25 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 98.40 E-value: 4.12e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 245 KQQIVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPFAvkepcYSNAAVeKLPLPTQDSRDII 324
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFR-----TITRSV-TLPSPTDDTDEIY 74
|
90 100 110
....*....|....*....|....*....|.
gi 446379660 325 AAACRALNHVWReGYRYMKAGVMLADFTPSG 355
Cdd:pfam11799 75 RAALRLLRRLYR-GRPVRLLGVSLSNLVPEG 104
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
6-331 |
6.42e-21 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 93.92 E-value: 6.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 6 DINSFYASCEKVFRPDLRNEPVIVLSN-NDGCVIAR-SPEAKALGIRMGQpWfqVRQMR-LEKKIHVFSSNYALYHSMSQ 82
Cdd:cd01701 53 DFDCFFVSVSIRNRPDLKGKPVAVCHGkGPNSEIAScNYEARSYGIKNGM-W--VGQAKkLCPQLVTLPYDFEAYEEVSL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 83 RVMAVLESLSPAVEPYSIDEMFIDLRGINHCIS--PEIFGHQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKqwPqfS 160
Cdd:cd01701 130 TFYEILASYTDNIEAVSCDEALIDITSLLEETYelPEELAEAIRNEIRETTGCSASVGIGPNILLARLATRKAK--P--D 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 161 GVVALTAENRNRTLKLLglqPVGEVWGVGRRLTEKLNALGINTALQLAQantafiRKNFSVILERTVRELNGES----CI 236
Cdd:cd01701 206 GQYHLSAEKVEEFLSQL---KVGDLPGVGSSLAEKLVKLFGDTCGGLEL------RSKTKEKLQKVLGPKTGEKlydyCR 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 237 SLEEAPPAKQQ----IVCSRSFGERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVT-TFVRTSPFAVKEP-------- 303
Cdd:cd01701 277 GIDDRPVTGEKerksVSAEINYGIRFTNVDDVEQFLQRLSEELSKRLEESNVTGRQITlKLMKRAPGAPIEPpkymghgi 356
|
330 340
....*....|....*....|....*...
gi 446379660 304 CYSNAAVEKLPLPTQDSRdIIAAACRAL 331
Cdd:cd01701 357 CDSFSKSSTLGVATDDSG-VIGTEAKKL 383
|
|
| DUF4113 |
pfam13438 |
Domain of unknown function (DUF4113); Although the function is not known this domain occurs ... |
374-421 |
4.06e-20 |
|
Domain of unknown function (DUF4113); Although the function is not known this domain occurs almost invariably at the very C-terminus of the IMS family DNA-polymerase repair proteins, IMS, pfam00817.
Pssm-ID: 463876 [Multi-domain] Cd Length: 49 Bit Score: 82.92 E-value: 4.06e-20
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 446379660 374 LMKTLDELNQS-GKGKVWFAGRGTAPEWQMKREMLSPAYTTRWTDLPVA 421
Cdd:pfam13438 1 LMAALDAINRRyGRGTVRLAAQGLKRDWKMRREHLSPRYTTRWDELPVV 49
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
1-202 |
6.61e-19 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 87.54 E-value: 6.61e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 1 MFALADINSFYASCEKVFRPDLRNEPVIVL-----SNNDGCVIARSPEAKALGIRMGQPWfqVRQMRLEKKIHVFSSNYA 75
Cdd:PRK01216 2 IILFVDFDYFFAQVEEVLNPSLKGKPVVVCvysgrFEDSGAVATANYEARKLGIKAGMPI--VEAKKILPNAVYLPMRKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 76 LYHSMSQRVMAVLESLSPAVEPYSIDEMFIDL----RGINHCISpeiFGHQLREQVKSWTGLTMGVGIAPTKTLAKSAqw 151
Cdd:PRK01216 80 VYQQVSNRIMKLLREYSEKIEIASIDEAYLDIsdkvKNYQDAYN---LGLEIKNKILEKEKITVTVGISKNKVFAKIA-- 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 446379660 152 ATKQWPQFSGVValTAENRNRTLKLLGlqpVGEVWGVGRRLTEKLNALGIN 202
Cdd:PRK01216 155 ADMAKPNGIKVI--DDEEVKRFINELD---IADIPGIGDITAEKLKKLGVN 200
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
10-362 |
2.51e-18 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 85.56 E-value: 2.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 10 FYASCEKVFRPDLRNEPVIVLSNND--GCVIARSPEAKALGIRMGQPwfQVRQMRLEKKIHVFSSNYALYHSMSQRVMAV 87
Cdd:PRK02406 4 FYAAVEMRDNPELRGKPVAVGGSPGrrGVISTCNYEARKFGVRSAMP--TAQALKLCPDLIFVPGRFDVYKEVSRQIREI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 88 LESLSPAVEPYSIDEMFIDLRGINHCISP------EIfghqlREQVKSWTGLTMGVGIAPTKTLAKSAQWATKqwP--QF 159
Cdd:PRK02406 82 FRRYTDLIEPLSLDEAYLDVTDNKLCIGSatliaqEI-----RQDIFEELGLTASAGVAPNKFLAKIASDWNK--PngLF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 160 sgVValTAENRNRTLKLLglqPVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSV-----------ILERTV- 227
Cdd:PRK02406 155 --VI--TPEEVDAFLATL---PVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKfgrrlyerargIDERPVk 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 228 --RELngEScISLEeappakqqivcsRSFGERITDKDAMHQA-------VVQYAERAAEKLRGerqycRQVTTFVRTSPF 298
Cdd:PRK02406 228 pdRER--KS-VGVE------------RTFAEDLYDLEACLAElprlaekLERRLERAKPDKRI-----KTVGVKLKFADF 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446379660 299 AVKepcysnaAVEKLPLPTQDSRDIIAAACRALNHVWREGYRYMKAGVMLADftPSGIAQPGLF 362
Cdd:PRK02406 288 QQT-------TKEHTADPLDKADLIELLAQALLRRLGGRGVRLLGVGVTLLE--PQLERQLLLD 342
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
3-338 |
7.22e-17 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 81.59 E-value: 7.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 3 ALADINSFYASCEKVFRPDLRNEPVIVLSNNDgcVIARSPEAKALGIRmgqpwfqvRQMRLE--KK-------IHVFS-- 71
Cdd:cd01702 1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNS--IIAVSYAARAFGVT--------RFMTIDeaKKkcpdlilAHVATyk 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 72 --SNYALYHSM----------------SQRVMAVLESLSPAVEPYSIDEMFIDLrGINHCispeifgHQLREQVKSWTGL 133
Cdd:cd01702 71 kgEDEADYHENpsparhkvsldpyrraSRKILNILKRFGDVVEKASIDEAYLDL-GSRIV-------EEIRQQVYDELGY 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 134 TMGVGIAPTKTLAKSAQWATKQWPQfsgvvalTAENRNRTLKLLGLQPVGEVWGVGRRL-TEKLNALGINTALQLAQ--A 210
Cdd:cd01702 143 TCSAGIAHNKMLAKLASGMNKPNAQ-------TILRNDAVASFLSSLPITSIRGLGGKLgEEIIDLLGLPTEGDVAGfrS 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 211 NTAFIRKNFSVILERTV-RELNGESCISLEEAPPAKqQIVCSRSFGERITDKDAM-HQAVVQYAERAAEKLRGER-QYCR 287
Cdd:cd01702 216 SESDLQEHFGEKLGEWLyNLLRGIDHEPVKPRPLPK-SMGSSKNFPGKTALSTEDvQHWLLVLASELNSRLEDDRyENNR 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 446379660 288 QVTTFVRTspfavkepcYSNAAVEKL-----PLPTQDSRDIIAAACRALNHVWREG 338
Cdd:cd01702 295 RPKTLVLS---------LRQRGDGVRrsrscALPRYDAQKIVKDAFKLIKAINEEG 341
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
6-209 |
1.73e-12 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 68.27 E-value: 1.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 6 DINSFYASCEKVFRPDLRNEPVIVLSNNdgCVIARSPEAKALGIRmgqpwfqvRQMRLE--KKI-----HVFSSNYALYH 78
Cdd:cd01703 4 DLDCFYAQVEEIRDPSLKSKPLGIQQKY--IVVTCNYEARRLGVK--------KLMSIKdaKEIcpdlvLVNGEDLTPFR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 79 SMSQRVMAVLESLSPA--VEPYSIDEMFIDLRGINHCISPEIFGHqLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKQW 156
Cdd:cd01703 74 DMSKKVYRLLRSYSWNdrVERLGFDENFMDVTEMRLLVASHIAYE-MRERIENELGLTCCAGIASNKLLAKLVGSVNKPN 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 446379660 157 PQfsgvVALTAENRNRTLKLLGLQPVGEVWGVGRRLTEKLNALGINTALQLAQ 209
Cdd:cd01703 153 QQ----TTLLPPSCADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQE 201
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
19-290 |
2.69e-10 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 61.24 E-value: 2.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 19 RPDLRNEPVIVLS-NNDGCVIARSPEAKALGIRMGQPwfqVRQMR-LEKKIHVFSSNYALYHSMSQRVMAVLESLSPAVE 96
Cdd:cd03468 17 RPADDEAPLAVVErKKAGRILACNAAARAAGVRPGMP---LAEALaLCPNLQVVEYDPEADARALQELALWLLRFTPLVA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 97 PYSIDEMFIDLRGINHC-ISPEIFGHQLREQVKSwTGLTMGVGIAPTKTLAKsaqWATKqwpqFSGVVALTAENRNRTLK 175
Cdd:cd03468 94 LDGPDGLLLDVTGCLHLfGGEDALAASLRAALAT-LGLSARAGIADTPGAAW---LLAR----AGGGRGVLRREALAAAL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 176 LLGLQPVGEVWGVGRRLTEKLNALGINTALQLAQANTAFIRKNFSVILERTVRELNGE--SCISLEEAPPAKQQIVcSRS 253
Cdd:cd03468 166 VLLAPLPVAALRLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQAYGRdpEPLLFSPPPPAFDFRL-ELQ 244
|
250 260 270
....*....|....*....|....*....|....*..
gi 446379660 254 FGERITdkDAMHQAVVQYAERAAEKLRGERQYCRQVT 290
Cdd:cd03468 245 LEEPIA--RGLLFPLRRLLEQLCAFLALRGLGARRLS 279
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
6-298 |
8.98e-10 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 60.42 E-value: 8.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 6 DINSFYASCEKVFRPDLRNEPVIVlsnndGCVIARSPE---AKALGIRMGQPWFQvrQMRLEKKIHVFSSNYALYHSMSQ 82
Cdd:PTZ00205 139 DMDMFYAAVEIKKHPEYAAIPLAI-----GTMTMLQTAnyvARGRGIRQGMPGFL--ALKICPNLLILPPDFDAYNEESN 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 83 RVMAVLESLSPAVEPYSIDEMFIDLRG----INHCISPEIFGHQLREQVKSWTGLTMGVGIAPTKTLAKSAQWATKqwPQ 158
Cdd:PTZ00205 212 TVRRIVAEYDPNYISFGLDELTLEVSAyierFEGTKTAEDVASELRVRVFGETKLTASAGIGPTAALAKIASNINK--PN 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379660 159 FSGVVAL-TAENRNRTLKLLGLQPVGevwGVGRRLTEKLNALGINTALQLAQAntafiRKNFSVIL-ERTVRELNGEScI 236
Cdd:PTZ00205 290 GQHDLNLhTRGDVMTYVRDLGLRSVP---GVGKVTEALLKGLGITTLSDIYNR-----RVELCYILhNNLFRFLLGAS-I 360
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446379660 237 SLEEAPPA----------------KQQIVCSRSFgERITDKDAMHQAVVQYAERAAEKLRGERQYCRQVTTFVRTSPF 298
Cdd:PTZ00205 361 GIMQWPDAataantencegatggqRKAISSERSF-TTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWASY 437
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
181-201 |
2.57e-04 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 38.15 E-value: 2.57e-04
|
| |
