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Conserved domains on  [gi|446383750|ref|WP_000461605|]
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MULTISPECIES: amino acid ABC transporter permease [Bacillus]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 2-213 1.79e-65

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 201.84  E-value: 1.79e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750   2 FEIFMSTYPTLLKATIVTLQLTLISLLLGSLIGLLFAFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFGITSV-VV 80
Cdd:COG0765    5 FSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLgID 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  81 FTPFWAGAIALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSLVA 160
Cdd:COG0765   85 LSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVS 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446383750 161 YVGLSELWGSGLSIAAGNFQQLDTYMIVGLYYLVLVLLFTYFVNLLEKRLQRK 213
Cdd:COG0765  165 VIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 2-213 1.79e-65

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 201.84  E-value: 1.79e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750   2 FEIFMSTYPTLLKATIVTLQLTLISLLLGSLIGLLFAFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFGITSV-VV 80
Cdd:COG0765    5 FSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLgID 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  81 FTPFWAGAIALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSLVA 160
Cdd:COG0765   85 LSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVS 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446383750 161 YVGLSELWGSGLSIAAGNFQQLDTYMIVGLYYLVLVLLFTYFVNLLEKRLQRK 213
Cdd:COG0765  165 VIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 10-211 7.41e-43

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 144.04  E-value: 7.41e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  10 PTLLKATIVTLQLTLISLLLGSLIGLLFAFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFGITSVVV---FTPFWA 86
Cdd:PRK09494  13 PLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAFNdlrIDPFTA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  87 GAIALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSLVAYVGLSE 166
Cdd:PRK09494  93 AVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGVAE 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446383750 167 LWGSGLSIAAGNFQQLDTYMIVGLYYLVLVLLFTYFVNLLEKRLQ 211
Cdd:PRK09494 173 LTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERRMK 217
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 10-210 3.00e-30

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 111.48  E-value: 3.00e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750   10 PTLLKATIVTLQLTLISLLLGSLIGLLFAFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFGITSV-VVFTPFWAGA 88
Cdd:TIGR03003  11 PTLIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIgIRLPALVAGV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750   89 IALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSLVAYVGLSELW 168
Cdd:TIGR03003  91 LGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLELM 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 446383750  169 GSGLSIAAGNFQQLDTYMIVGLYYLVLVLLFTYFVNLLEKRL 210
Cdd:TIGR03003 171 NQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 37-189 7.73e-18

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 78.09  E-value: 7.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  37 FAFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFGI----TSVVVFTPFWAGAIALAIHNGAYITEIFRGSIQSVDR 112
Cdd:cd06261   22 LGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFgvllGWGILPGLGLPALILALLLIAPFARLIRRAALESIPK 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446383750 113 GQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSLVAYVGLSELWGSGLSIAAGNFQQLDTYMIVG 189
Cdd:cd06261  102 DLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGLLLIFAILFPGDLGVA 178
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 45-180 6.48e-15

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 70.02  E-value: 6.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750   45 NKVLNSIAHVYIAIIRGTPLIVQIAILYFGITSVVVFTPFWAGAIALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMP 124
Cdd:pfam00528  13 GRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGAS 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 446383750  125 YPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSLVAYVGLSELWGSGLSIAAGNFQ 180
Cdd:pfam00528  93 RWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYD 148
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 2-213 1.79e-65

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 201.84  E-value: 1.79e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750   2 FEIFMSTYPTLLKATIVTLQLTLISLLLGSLIGLLFAFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFGITSV-VV 80
Cdd:COG0765    5 FSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLgID 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  81 FTPFWAGAIALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSLVA 160
Cdd:COG0765   85 LSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVS 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446383750 161 YVGLSELWGSGLSIAAGNFQQLDTYMIVGLYYLVLVLLFTYFVNLLEKRLQRK 213
Cdd:COG0765  165 VIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARG 217
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 2-212 5.95e-44

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 147.16  E-value: 5.95e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750   2 FEIFMSTYPTLLKATIVTLQLTLISLLLGSLIGLLFAFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFGITSV--- 78
Cdd:COG4160    3 LDLLFEYLPLLLSGLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYGLGQFewv 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  79 ------VVFT-PFWAGAIALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFII 151
Cdd:COG4160   83 reswlwPLLRdPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEVIL 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446383750 152 GLKDSSLVAYVGLSELWGSGLSIAAGNFQQLDTYMIVGLYYLVLVLLFTYFVNLLEKRLQR 212
Cdd:COG4160  163 MLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRLLR 223
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 10-211 7.41e-43

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 144.04  E-value: 7.41e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  10 PTLLKATIVTLQLTLISLLLGSLIGLLFAFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFGITSVVV---FTPFWA 86
Cdd:PRK09494  13 PLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAFNdlrIDPFTA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  87 GAIALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSLVAYVGLSE 166
Cdd:PRK09494  93 AVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGVAE 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446383750 167 LWGSGLSIAAGNFQQLDTYMIVGLYYLVLVLLFTYFVNLLEKRLQ 211
Cdd:PRK09494 173 LTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERRMK 217
ArtQ COG4215
ABC-type arginine transport system, permease component [Amino acid transport and metabolism];
38-212 3.65e-40

ABC-type arginine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443361 [Multi-domain]  Cd Length: 238  Bit Score: 137.56  E-value: 3.65e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  38 AFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFGITS-------------VVVFTPFWAGAIALAIHNGAYITEIFR 104
Cdd:COG4215   44 ALAKLSGNRPLRWLATGYTTVVRGVPDLLLILLLYFGGQIllnaladlfgydgFIEINPFVAGVLALGFVFGAYATEVFR 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750 105 GSIQSVDRGQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSLVAYVGLSELWGSGLSIAAGNFQQLDT 184
Cdd:COG4215  124 GAFLAVPKGQIEAARAYGMSRWQVFRRILLPQMWRYALPGLGNNWLVLLKDTALVSVIGLVDLVRQAQEAAGSTREPFTF 203

                        170       180
                 ....*....|....*....|....*...
gi 446383750 185 YMIVGLYYLVLVLLFTYFVNLLEKRLQR 212
Cdd:COG4215  204 YLAAALIYLALTTVSELVLARLERRASR 231
PRK15100 PRK15100
cystine ABC transporter permease;
2-214 4.52e-37

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 129.10  E-value: 4.52e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750   2 FEIFMSTYPTLLKATIVTLQLTLISLLLGSLIGLLFAFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFGITSV-VV 80
Cdd:PRK15100   5 IQLVIDSAPFLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFgIE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  81 FTPFWAGAIALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSLVA 160
Cdd:PRK15100  85 LDPIPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAA 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446383750 161 YVGLSELWGSGLSIAAGNFQQLDTYMIVGLYYLVLVLLFTYFVNLLEKRLQRKE 214
Cdd:PRK15100 165 TIQVPELFRQAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQLNRQE 218
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 10-210 3.00e-30

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 111.48  E-value: 3.00e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750   10 PTLLKATIVTLQLTLISLLLGSLIGLLFAFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFGITSV-VVFTPFWAGA 88
Cdd:TIGR03003  11 PTLIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIgIRLPALVAGV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750   89 IALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSLVAYVGLSELW 168
Cdd:TIGR03003  91 LGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLELM 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 446383750  169 GSGLSIAAGNFQQLDTYMIVGLYYLVLVLLFTYFVNLLEKRL 210
Cdd:TIGR03003 171 NQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 10-212 6.19e-27

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 102.62  E-value: 6.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750   10 PTLLKATIVTLQLTLISLLLGSLIGLLFAFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFGITSV-VVFTPFWAGA 88
Cdd:TIGR03004   5 PLLLQGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLPLIgLSLDPVTTGV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750   89 IALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSLVAYVGLSELW 168
Cdd:TIGR03004  85 MVLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLADLT 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 446383750  169 GSGLSIAAGNFQQLDTYMIVGLYYLVLVLLFTYFVNLLEKRLQR 212
Cdd:TIGR03004 165 FAAQSIRNLTLDTLSIFAITLLCYFVMALIIMLIMRVLERVVRR 208
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
6-214 4.88e-25

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 98.21  E-value: 4.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750   6 MSTYPTLLKATIVTLQLTLISLLLGSLIGLLFAFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFGITSVVV----- 80
Cdd:PRK11123   1 MNEFFPLASAAGMTVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPEILVVLFIYFGSSQLLLtlsdg 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  81 --------------------FTPFWAGAIALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMPYPLAMRRIVLPQAFRQ 140
Cdd:PRK11123  81 ftlnlgfvqipvqmdienfeVSPFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRH 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446383750 141 SIPPLGNQFIIGLKDSSLVAYVGLSELWGSGLSIAAGNFQQLDTYMIVGLYYLVLVLLFTYFVNLLEKRLQRKE 214
Cdd:PRK11123 161 ALPGLGNQWLVLLKDTALVSLISVNDLMLQTKSIATRTQEPFTWYIIAAAIYLVITLISQYILKRIELRATRFE 234
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 79-167 3.74e-22

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 93.29  E-value: 3.74e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  79 VVFTP-FWAGAIALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSS 157
Cdd:COG4597  259 LTLSPeFVALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLTKNSS 338

                         90
                 ....*....|
gi 446383750 158 LVAYVGLSEL 167
Cdd:COG4597  339 LAVAIGYPDL 348
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
10-209 4.37e-18

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 79.49  E-value: 4.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  10 PTLLKATIVTLQLTLISLLLGSLIGLLFAFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFGITS----VVVFTP-- 83
Cdd:PRK15107  14 PYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGflqnVLGLSPkt 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  84 ---FWAGAIALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSLVA 160
Cdd:PRK15107  94 dirLISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVY 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 446383750 161 YVGLSELWGSGLSIAAGNFQQLDTYMIVGLYYLVLVLLFTYFVNLLEKR 209
Cdd:PRK15107 174 VLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKKR 222
PRK15069 PRK15069
histidine ABC transporter permease HisM;
38-158 5.10e-18

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 79.71  E-value: 5.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  38 AFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFGITSVVV------FTPFWAGAI-----ALAIHNGAYITEIFRGS 106
Cdd:PRK15069  45 AIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYTGMYSLEIvrgtdlLDAFFRSGLnctilAFTLNTCAYTTEIFAGA 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446383750 107 IQSVDRGQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSL 158
Cdd:PRK15069 125 IRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTL 176
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 37-189 7.73e-18

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 78.09  E-value: 7.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  37 FAFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFGI----TSVVVFTPFWAGAIALAIHNGAYITEIFRGSIQSVDR 112
Cdd:cd06261   22 LGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFgvllGWGILPGLGLPALILALLLIAPFARLIRRAALESIPK 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446383750 113 GQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSLVAYVGLSELWGSGLSIAAGNFQQLDTYMIVG 189
Cdd:cd06261  102 DLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGLLLIFAILFPGDLGVA 178
artM PRK11122
arginine ABC transporter permease ArtM;
37-169 2.59e-17

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 77.31  E-value: 2.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  37 FAFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFG---ITSVVVFTPFWA--------GAIALAIHNGAYITEIFRG 105
Cdd:PRK11122  33 FTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGpgqFPWLQEYPWLWHllsqpwlcAMLALALNSAAYSTQLFYG 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446383750 106 SIQSVDRGQMEAARSLGMPyPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSLVAYVGLSELWG 169
Cdd:PRK11122 113 AVRAIPEGQWQSCAALGMS-KKQTLRILLPYAFKRALSSYSNEVVLVFKSTSLAYTITLMDVMG 175
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
41-167 3.02e-16

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 74.83  E-value: 3.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  41 RISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFG-------ITSVVVFT-----PFWAGAIALAIHNGAYITEIFRGSIQ 108
Cdd:PRK15135  38 KLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGlqialnsVTEALGVGqididPMVAGIITLGFIYGAYFTETFRGAFM 117

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446383750 109 SVDRGQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSLVAYVGLSEL 167
Cdd:PRK15135 118 AVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALVSLLGLEDV 176
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 9-105 1.76e-15

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 69.48  E-value: 1.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750    9 YPTLLKATIVTLQLTLISLLLGSLIGLLFAFFRISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFGITSV-VVFTPFWAG 87
Cdd:TIGR01726   2 LPFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIgIRLSPLTAA 81

                          90
                  ....*....|....*...
gi 446383750   88 AIALAIHNGAYITEIFRG 105
Cdd:TIGR01726  82 VIALTLFYGAYLAEIFRG 99
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 45-180 6.48e-15

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 70.02  E-value: 6.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750   45 NKVLNSIAHVYIAIIRGTPLIVQIAILYFGITSVVVFTPFWAGAIALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMP 124
Cdd:pfam00528  13 GRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGAS 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 446383750  125 YPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSSLVAYVGLSELWGSGLSIAAGNFQ 180
Cdd:pfam00528  93 RWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYD 148
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 37-140 1.06e-09

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 56.63  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  37 FAFF---RISNNKVLNSIAHVYIAIIRGTPLIVqIAILYfgiTSVVVFTPFwAGAIALAIHNGAYITEIFRGSIQSVDRG 113
Cdd:COG3639   74 LAFLaarNLAPNPWVRLLARRLLNVLRAIPELV-WALIF---VAAVGLGPF-AGVLALAIHTIGFLGKLFAEAIEEIDPG 148

                         90       100
                 ....*....|....*....|....*..
gi 446383750 114 QMEAARSLGMPYPLAMRRIVLPQAFRQ 140
Cdd:COG3639  149 PVEALRATGASRLQVIRYGVLPQVLPQ 175
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 1-163 6.61e-09

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 54.47  E-value: 6.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750    1 MFEIFMSTYPTLLKATIVTLQLTLISLLLGSLIGLLFAFF---RISNNKVLNSIAHVYIAIIRGTPLIVQIAILYFgits 77
Cdd:TIGR01097  45 MFPPDWSYLPRILKALLETLAMAILGTVLAAVLAVPLALLaarNITPSPWLYGLARLLLNFLRAIPELVWALIFVA---- 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750   78 VVVFTPFwAGAIALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMPYPLAMRRIVLPQAFRQSIPPLGNQFIIGLKDSS 157
Cdd:TIGR01097 121 AVGLGPF-AGVLALAFHTVGFLGKLFAEAIEEVDPGPVEALRATGASKLQVIRYGVLPQVLPQFLSYTLYRFEINVRAAA 199


                  ....*.
gi 446383750  158 LVAYVG 163
Cdd:TIGR01097 200 VLGLVG 205
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
51-137 9.78e-06

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 45.92  E-value: 9.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  51 IAHVYIAIIRGTPLIVQIAILYFGITSVVVFTpFWAGAIALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMPYPLAMR 130
Cdd:COG1178  107 VALAWIALFGPNGLLNTLLRALFGLEPPDIYG-LGGIILVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFR 185


                 ....*..
gi 446383750 131 RIVLPQA 137
Cdd:COG1178  186 RVTLPLL 192
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 45-137 3.55e-04

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 40.52  E-value: 3.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446383750  45 NKVLNSIAHVYIAIIRGTPLI--VQIAILYFGITS-----VVVFTPFWAgaIALAIHNGayiteifrgsIQSVDRGQMEA 117
Cdd:COG0600   91 SRLLRRLLDPLLVFLRPIPPLalAPLLILWFGIGEaskifVIFLGAFFP--ILLNTAAG----------VRSVDPELLEL 158

                         90       100
                 ....*....|....*....|
gi 446383750 118 ARSLGMPYPLAMRRIVLPQA 137
Cdd:COG0600  159 ARSLGASRWQILRKVVLPAA 178
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 63-137 3.94e-03

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 37.40  E-value: 3.94e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446383750  63 PLIVQIAILYFGITSVVVFTpFWAGAIALAIHNGAYITEIFRGSIQSVDRGQMEAARSLGMPYPLAMRRIVLPQA 137
Cdd:COG1177  111 GIVLGVALLLLFSALGLSGG-LWGLILAHVVFTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLI 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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