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Conserved domains on  [gi|446390152|ref|WP_000468007|]
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MULTISPECIES: capsular polyglutamate amide ligase/translocase CapC [Bacillus]

Protein Classification

poly-gamma-glutamate biosynthesis protein PgsC/CapC( domain architecture ID 10024291)

poly-gamma-glutamate biosynthesis protein PgsC/CapC is a component of the polyglutamyl synthetase complex and is essential for the synthesis of the polyglutamate capsule

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
poly_gGlu_PgsC TIGR04011
poly-gamma-glutamate biosynthesis protein PgsC/CapC; Of four genes commonly found to be ...
 10-140 1.51e-42

poly-gamma-glutamate biosynthesis protein PgsC/CapC; Of four genes commonly found to be involved in biosynthesis and export of poly-gamma-glutamate, pgsB(capB) and pgsC(capC) are found to be involved in the synthesis per se. Members of this family are designated PgsC, covering both cases in which the poly-gamma-glutamate is secreted and those in which it is retained to form capsular material. PgsC binds tightly to PgsB, which has been shown to have poly-gamma-glutamate activity. [Cell envelope, Other]


:

Pssm-ID: 274916  Cd Length: 132  Bit Score: 137.42  E-value: 1.51e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446390152   10 LVLGVTLSLIFTERTGILPAGLVVPGYLALVFNQPVFMLVVLFISILTYVIVtYGVSRFMILYGRRKFAATLITGICLKL 89
Cdd:TIGR04011   1 IGIGVILSLVFTEITGISPGGLVVPGYLALFLDQPVLIIVTILISILTYLIV-RVISKFTILYGRRKFVATIILSILLKT 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 446390152   90 LFDYCYPVM--PFEIFEFRGIGVIVPGLIANTIQRQGLPLTIGTTILLSGATF 140
Cdd:TIGR04011  80 LVHFLFPVYaeSFYIFGLAVIGIIVPGLIALTIDRQGVIKTLSSLVILSVLTR 132
 
Name Accession Description Interval E-value
poly_gGlu_PgsC TIGR04011
poly-gamma-glutamate biosynthesis protein PgsC/CapC; Of four genes commonly found to be ...
 10-140 1.51e-42

poly-gamma-glutamate biosynthesis protein PgsC/CapC; Of four genes commonly found to be involved in biosynthesis and export of poly-gamma-glutamate, pgsB(capB) and pgsC(capC) are found to be involved in the synthesis per se. Members of this family are designated PgsC, covering both cases in which the poly-gamma-glutamate is secreted and those in which it is retained to form capsular material. PgsC binds tightly to PgsB, which has been shown to have poly-gamma-glutamate activity. [Cell envelope, Other]


Pssm-ID: 274916  Cd Length: 132  Bit Score: 137.42  E-value: 1.51e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446390152   10 LVLGVTLSLIFTERTGILPAGLVVPGYLALVFNQPVFMLVVLFISILTYVIVtYGVSRFMILYGRRKFAATLITGICLKL 89
Cdd:TIGR04011   1 IGIGVILSLVFTEITGISPGGLVVPGYLALFLDQPVLIIVTILISILTYLIV-RVISKFTILYGRRKFVATIILSILLKT 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 446390152   90 LFDYCYPVM--PFEIFEFRGIGVIVPGLIANTIQRQGLPLTIGTTILLSGATF 140
Cdd:TIGR04011  80 LVHFLFPVYaeSFYIFGLAVIGIIVPGLIALTIDRQGVIKTLSSLVILSVLTR 132
Caps_synth_CapC pfam14102
Capsule biosynthesis CapC; This family of proteins play a role in capsule biosynthesis. They ...
 12-129 2.24e-31

Capsule biosynthesis CapC; This family of proteins play a role in capsule biosynthesis. They are essential for gamma-polyglutamic acid (PGA) production.


Pssm-ID: 464084  Cd Length: 119  Bit Score: 108.40  E-value: 2.24e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446390152   12 LGVTLSLIFTERTGILPAGLVVPGYLALVFNQPVFMLVVLFISILTYVIVTYgVSRFMILYGRRKFAATLITGICLKLLF 91
Cdd:pfam14102   1 IGLLLSLLFTERTGLSPGGLIVPGYLALYLDDPLRLLVTLLISLLTYLIVRL-LSRFTILYGRRRFAAALLLGVLLKLLL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 446390152   92 DYCYPVM-PFEI-FEFRGIGVIVPGLIANTIQRQGLPLTI 129
Cdd:pfam14102  80 DLFLPLWfPFLFdGELRGIGYIVPGLIANDLQRQGVVRTL 119
 
Name Accession Description Interval E-value
poly_gGlu_PgsC TIGR04011
poly-gamma-glutamate biosynthesis protein PgsC/CapC; Of four genes commonly found to be ...
 10-140 1.51e-42

poly-gamma-glutamate biosynthesis protein PgsC/CapC; Of four genes commonly found to be involved in biosynthesis and export of poly-gamma-glutamate, pgsB(capB) and pgsC(capC) are found to be involved in the synthesis per se. Members of this family are designated PgsC, covering both cases in which the poly-gamma-glutamate is secreted and those in which it is retained to form capsular material. PgsC binds tightly to PgsB, which has been shown to have poly-gamma-glutamate activity. [Cell envelope, Other]


Pssm-ID: 274916  Cd Length: 132  Bit Score: 137.42  E-value: 1.51e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446390152   10 LVLGVTLSLIFTERTGILPAGLVVPGYLALVFNQPVFMLVVLFISILTYVIVtYGVSRFMILYGRRKFAATLITGICLKL 89
Cdd:TIGR04011   1 IGIGVILSLVFTEITGISPGGLVVPGYLALFLDQPVLIIVTILISILTYLIV-RVISKFTILYGRRKFVATIILSILLKT 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 446390152   90 LFDYCYPVM--PFEIFEFRGIGVIVPGLIANTIQRQGLPLTIGTTILLSGATF 140
Cdd:TIGR04011  80 LVHFLFPVYaeSFYIFGLAVIGIIVPGLIALTIDRQGVIKTLSSLVILSVLTR 132
Caps_synth_CapC pfam14102
Capsule biosynthesis CapC; This family of proteins play a role in capsule biosynthesis. They ...
 12-129 2.24e-31

Capsule biosynthesis CapC; This family of proteins play a role in capsule biosynthesis. They are essential for gamma-polyglutamic acid (PGA) production.


Pssm-ID: 464084  Cd Length: 119  Bit Score: 108.40  E-value: 2.24e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446390152   12 LGVTLSLIFTERTGILPAGLVVPGYLALVFNQPVFMLVVLFISILTYVIVTYgVSRFMILYGRRKFAATLITGICLKLLF 91
Cdd:pfam14102   1 IGLLLSLLFTERTGLSPGGLIVPGYLALYLDDPLRLLVTLLISLLTYLIVRL-LSRFTILYGRRRFAAALLLGVLLKLLL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 446390152   92 DYCYPVM-PFEI-FEFRGIGVIVPGLIANTIQRQGLPLTI 129
Cdd:pfam14102  80 DLFLPLWfPFLFdGELRGIGYIVPGLIANDLQRQGVVRTL 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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