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Conserved domains on  [gi|446395008|ref|WP_000472863|]
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MULTISPECIES: acetyl-CoA carboxylase biotin carboxyl carrier protein [Bacillus]

Protein Classification

acetyl-CoA carboxylase biotin carboxyl carrier protein( domain architecture ID 1010446)

acetyl-CoA carboxylase biotin carboxyl carrier protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

CATH:  2.40.50.100
Gene Ontology:  GO:0003989|GO:0006633
SCOP:  4002909
TCDB:  3.B.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BCCP super family cl36680
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify ...
 4-161 1.28e-52

acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase.The gene name is accB or fabE. [Fatty acid and phospholipid metabolism, Biosynthesis]


The actual alignment was detected with superfamily member TIGR00531:

Pssm-ID: 273123 [Multi-domain]  Cd Length: 155  Bit Score: 164.24  E-value: 1.28e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008    4 IQEVRELIKLIDSSNIDEFEYKKDGTTIKMKKRG--NEVVAVQAPAAKQAMQPVAPVEVETTVAAAQAEAPKQeekktvq 81
Cdd:TIGR00531   3 IREIKELIKLVEESGITELELKEEEFSVRLSKAAaaASFSVVQQAAAPVPAQVPAQSSAAVPAPAPAAPAPAA------- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008   82 DENLHKITSPMVGTFYSSSSPDTPPYVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLFLVK 161
Cdd:TIGR00531  76 DIKGHIVRSPMVGTFYRAPSPDAKPFVEVGDKVNKGQTVCIVEAMKMMNEIEAEKAGTVVAILVENGQPVEYGEPLIVIE 155
 
Name Accession Description Interval E-value
BCCP TIGR00531
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify ...
 4-161 1.28e-52

acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase.The gene name is accB or fabE. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273123 [Multi-domain]  Cd Length: 155  Bit Score: 164.24  E-value: 1.28e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008    4 IQEVRELIKLIDSSNIDEFEYKKDGTTIKMKKRG--NEVVAVQAPAAKQAMQPVAPVEVETTVAAAQAEAPKQeekktvq 81
Cdd:TIGR00531   3 IREIKELIKLVEESGITELELKEEEFSVRLSKAAaaASFSVVQQAAAPVPAQVPAQSSAAVPAPAPAAPAPAA------- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008   82 DENLHKITSPMVGTFYSSSSPDTPPYVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLFLVK 161
Cdd:TIGR00531  76 DIKGHIVRSPMVGTFYRAPSPDAKPFVEVGDKVNKGQTVCIVEAMKMMNEIEAEKAGTVVAILVENGQPVEYGEPLIVIE 155
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 10-161 4.27e-50

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 157.36  E-value: 4.27e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008  10 LIKLIDSSNIDEFEYKKDGTTIKMKKRGNevvAVQAPAAkqAMQPVAPVEVETTVAAAQAEAPkqeekktvqdeNLHKIT 89
Cdd:COG0511    1 LIELLEESGLTELEVEEGEYKVRIKRGGA---AAAAPVA--APAAAAPAAAAPAAAAAAAAAS-----------GGGAVK 64

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446395008  90 SPMVGTFYSSSSPDTPPYVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLFLVK 161
Cdd:COG0511   65 SPMVGTFYRAPSPGAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVIE 136
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 4-160 2.22e-32

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 116.09  E-value: 2.22e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008   4 IQEVRELIKLIDSSNIDEFEYKKDGTTIKMKKR--------GNEVVAVQ-------APAAKQAMQPVAPVEVETTVAAAQ 68
Cdd:PLN02983 106 MTQVSSLVKLVDSRDIVELQLKQLDCELVIRKKealpqpppPAPVVMMQpppphamPPASPPAAQPAPSAPASSPPPTPA 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008  69 AEAPKQEEKKTvqdenLHKITSPMVGTFYSSSSPDTPPYVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNG 148
Cdd:PLN02983 186 SPPPAKAPKSS-----HPPLKSPMAGTFYRSPAPGEPPFVKVGDKVQKGQVVCIIEAMKLMNEIEADQSGTIVEILAEDG 260

                        170
                 ....*....|..
gi 446395008 149 QLVEYGQPLFLV 160
Cdd:PLN02983 261 KPVSVDTPLFVI 272
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 88-160 2.42e-21

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 81.69  E-value: 2.42e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446395008  88 ITSPMVGTFYSssspdtpPYVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLFLV 160
Cdd:cd06850    2 VTAPMPGTVVK-------VLVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 86-158 1.81e-17

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 72.25  E-value: 1.81e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446395008   86 HKITSPMVGTFYSSssPDTPPYVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLF 158
Cdd:pfam00364   1 TEIKSPMIGESVRE--GVVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLA 71
 
Name Accession Description Interval E-value
BCCP TIGR00531
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify ...
 4-161 1.28e-52

acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase.The gene name is accB or fabE. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273123 [Multi-domain]  Cd Length: 155  Bit Score: 164.24  E-value: 1.28e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008    4 IQEVRELIKLIDSSNIDEFEYKKDGTTIKMKKRG--NEVVAVQAPAAKQAMQPVAPVEVETTVAAAQAEAPKQeekktvq 81
Cdd:TIGR00531   3 IREIKELIKLVEESGITELELKEEEFSVRLSKAAaaASFSVVQQAAAPVPAQVPAQSSAAVPAPAPAAPAPAA------- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008   82 DENLHKITSPMVGTFYSSSSPDTPPYVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLFLVK 161
Cdd:TIGR00531  76 DIKGHIVRSPMVGTFYRAPSPDAKPFVEVGDKVNKGQTVCIVEAMKMMNEIEAEKAGTVVAILVENGQPVEYGEPLIVIE 155
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 10-161 4.27e-50

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 157.36  E-value: 4.27e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008  10 LIKLIDSSNIDEFEYKKDGTTIKMKKRGNevvAVQAPAAkqAMQPVAPVEVETTVAAAQAEAPkqeekktvqdeNLHKIT 89
Cdd:COG0511    1 LIELLEESGLTELEVEEGEYKVRIKRGGA---AAAAPVA--APAAAAPAAAAPAAAAAAAAAS-----------GGGAVK 64

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446395008  90 SPMVGTFYSSSSPDTPPYVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLFLVK 161
Cdd:COG0511   65 SPMVGTFYRAPSPGAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVIE 136
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 4-160 2.22e-32

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 116.09  E-value: 2.22e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008   4 IQEVRELIKLIDSSNIDEFEYKKDGTTIKMKKR--------GNEVVAVQ-------APAAKQAMQPVAPVEVETTVAAAQ 68
Cdd:PLN02983 106 MTQVSSLVKLVDSRDIVELQLKQLDCELVIRKKealpqpppPAPVVMMQpppphamPPASPPAAQPAPSAPASSPPPTPA 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008  69 AEAPKQEEKKTvqdenLHKITSPMVGTFYSSSSPDTPPYVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNG 148
Cdd:PLN02983 186 SPPPAKAPKSS-----HPPLKSPMAGTFYRSPAPGEPPFVKVGDKVQKGQVVCIIEAMKLMNEIEADQSGTIVEILAEDG 260

                        170
                 ....*....|..
gi 446395008 149 QLVEYGQPLFLV 160
Cdd:PLN02983 261 KPVSVDTPLFVI 272
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 21-161 1.38e-25

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 101.46  E-value: 1.38e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008  21 EFEYKKDGTTIKMKKRGnevvaVQAPAAKQAMQPVAPVEVETTVAAAQAEAPKQEEKKTVQDEnlhkITSPMVGTFYSSs 100
Cdd:PRK09282 467 EFKVEVDGEKYEVKIEG-----VKAEGKRPFYLRVDGMPEEVVVEPLKEIVVGGRPRASAPGA----VTSPMPGTVVKV- 536

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446395008 101 spdtppYVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLFLVK 161
Cdd:PRK09282 537 ------KVKEGDKVKAGDTVLVLEAMKMENEIQAPVDGTVKEILVKEGDRVNPGDVLMEIE 591
PRK07051 PRK07051
biotin carboxyl carrier domain-containing protein;
85-157 2.51e-23

biotin carboxyl carrier domain-containing protein;


Pssm-ID: 180811 [Multi-domain]  Cd Length: 80  Bit Score: 87.38  E-value: 2.51e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446395008  85 LHKITSPMVGTFYSSSSPDTPPYVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPL 157
Cdd:PRK07051   3 QHEIVSPLPGTFYRRPSPDAPPYVEVGDAVAAGDVVGLIEVMKQFTEVEAEAAGRVVEFLVEDGEPVEAGQVL 75
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 88-160 2.42e-21

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 81.69  E-value: 2.42e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446395008  88 ITSPMVGTFYSssspdtpPYVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLFLV 160
Cdd:cd06850    2 VTAPMPGTVVK-------VLVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 86-158 1.81e-17

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 72.25  E-value: 1.81e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446395008   86 HKITSPMVGTFYSSssPDTPPYVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLF 158
Cdd:pfam00364   1 TEIKSPMIGESVRE--GVVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLA 71
PRK06549 PRK06549
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 44-157 1.62e-11

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235826 [Multi-domain]  Cd Length: 130  Bit Score: 58.28  E-value: 1.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008  44 QAPAAKQAMQPVAPVEVETTVAAAQAEAPKQEEKKTVqdenlhkITSPMVGTFysssspdTPPYVSVGDRVSKDSIVCIV 123
Cdd:PRK06549  27 AAAPAQPASTPVPVPTEASPQVEAQAPQPAAAAGADA-------MPSPMPGTI-------LKVLVAVGDQVTENQPLLIL 92

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446395008 124 EAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPL 157
Cdd:PRK06549  93 EAMKMENEIVASSAGTVTAIHVTPGQVVNPGDGL 126
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 41-157 5.89e-09

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 51.79  E-value: 5.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008  41 VAVQAPAAKQAMQPVAPVEVETTVAAAQAEAPKQEEKKTVqdenlhkiTSPMVGTFYSSsspdtppYVSVGDRVSKDSIV 120
Cdd:PRK05641  48 VQEQVPTPAPAPAPAVPSAPTPVAPAAPAPAPASAGENVV--------TAPMPGKILRI-------LVREGQQVKVGQGL 112

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446395008 121 CIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPL 157
Cdd:PRK05641 113 LILEAMKMENEIPAPKDGVVKKILVKEGDTVDTGQPL 149
Biotinyl_lipoyl_domains cd06663
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the ...
 108-158 4.35e-08

Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, or methylamine, respectively, between components of the complex/protein via a biotinyl or lipoyl group, which is covalently attached to a highly conserved lysine residue.


Pssm-ID: 133456 [Multi-domain]  Cd Length: 73  Bit Score: 47.82  E-value: 4.35e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446395008 108 VSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLF 158
Cdd:cd06663   21 KKVGDKVKKGDVLAEIEAMKATSDVEAPKSGTVKKVLVKEGTKVEGDTPLV 71
PycA COG1038
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
 57-155 5.99e-08

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 50.85  E-value: 5.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008   57 PVEVE-TTVAAAQAEAPKQEEkktvqdENLHKITSPMVGTFYSSSspdtppyVSVGDRVSKDSIVCIVEAMKLFNEIDAD 135
Cdd:COG1038  1053 EVRVRdRSVKVTVASREKADP------GNPGHIGAPMPGTVVKVL-------VKEGDEVKKGDPLLTIEAMKMETTITAP 1119

                          90       100
                  ....*....|....*....|
gi 446395008  136 VEGEIVEILVNNGQLVEYGQ 155
Cdd:COG1038  1120 RDGTVKEVLVKEGDQVEAGD 1139
PRK14040 PRK14040
oxaloacetate decarboxylase subunit alpha;
40-157 8.11e-08

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 237592 [Multi-domain]  Cd Length: 593  Bit Score: 50.31  E-value: 8.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008  40 VVAVQAPAAKQAMQPVAPVEVETTVAAAQAEAPKQEEkktvqdenlhkITSPMVGTFYSSsspdtppYVSVGDRVSKDSI 119
Cdd:PRK14040 490 VVKVSEGGDISQITPAAPAAAPAAAAAAAPAAAAGEP-----------VTAPLAGNIFKV-------IVTEGQTVAEGDV 551

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446395008 120 VCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPL 157
Cdd:PRK14040 552 LLILEAMKMETEIRAAQAGTVRGIAVKEGDAVAVGDTL 589
lipoyl_domain cd06849
Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. ...
 107-160 1.23e-07

Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid dehydrogenase (BCDH), contain at least three different enzymes, 2-oxo acid dehydrogenase (E1), dihydrolipoyl acyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) and play a key role in redox regulation. E2, the central component of the complex, catalyzes the transfer of the acyl group of CoA from E1 to E3 via reductive acetylation of a lipoyl group covalently attached to a lysine residue.


Pssm-ID: 133458 [Multi-domain]  Cd Length: 74  Bit Score: 46.63  E-value: 1.23e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446395008 107 YVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLFLV 160
Cdd:cd06849   21 LVKEGDSVEEGDVLAEVETDKATVEVEAPAAGVLAKILVEEGDTVPVGQVIAVI 74
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 53-162 2.46e-07

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 49.05  E-value: 2.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008  53 QPVAPVEVETTVAAAQAEAPKQEEKKTVQDENLHKITSPMVGTFYSSSS------PDTPPY---------VSVGDRVSKD 117
Cdd:PRK11855  70 GLLAVIEAAGAAAAAAAPAAAAAPAAAAAAAPAPAAAAPAAAAAAAGGGvvevkvPDIGEIteveviewlVKVGDTVEED 149

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 446395008 118 SIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLFLVKA 162
Cdd:PRK11855 150 QSLITVETDKATMEIPSPVAGVVKEIKVKVGDKVSVGSLLVVIEV 194
PTZ00144 PTZ00144
dihydrolipoamide succinyltransferase; Provisional
 108-162 1.19e-06

dihydrolipoamide succinyltransferase; Provisional


Pssm-ID: 240289 [Multi-domain]  Cd Length: 418  Bit Score: 46.98  E-value: 1.19e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446395008 108 VSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLFLVKA 162
Cdd:PTZ00144  66 KKVGDYVKEDEVICIIETDKVSVDIRAPASGVITKIFAEEGDTVEVGAPLSEIDT 120
PRK12999 PRK12999
pyruvate carboxylase; Reviewed
 57-155 1.42e-06

pyruvate carboxylase; Reviewed


Pssm-ID: 237263 [Multi-domain]  Cd Length: 1146  Bit Score: 47.06  E-value: 1.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008   57 PVEVE-TTVAAAQAEAPKQEEkktvqdENLHKITSPMVGTFYSssspdtpPYVSVGDRVSKDSIVCIVEAMKLFNEIDAD 135
Cdd:PRK12999 1053 EVQVRdRSVKSTVAAREKADP------GNPGHVGAPMPGSVVT-------VLVKEGDEVKAGDPLAVIEAMKMETTITAP 1119

                          90       100
                  ....*....|....*....|
gi 446395008  136 VEGEIVEILVNNGQLVEYGQ 155
Cdd:PRK12999 1120 VDGTVKRVLVKAGDQVEAGD 1139
AceF COG0508
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component ...
 107-160 2.89e-06

Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [Energy production and conversion]; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440274 [Multi-domain]  Cd Length: 77  Bit Score: 42.75  E-value: 2.89e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446395008 107 YVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLFLV 160
Cdd:COG0508   23 LVKEGDTVKEGDPLAEVETDKATMEVPAPAAGVLLEILVKEGDTVPVGAVIAVI 76
PRK14042 PRK14042
pyruvate carboxylase subunit B; Provisional
 107-161 4.37e-05

pyruvate carboxylase subunit B; Provisional


Pssm-ID: 172536 [Multi-domain]  Cd Length: 596  Bit Score: 42.40  E-value: 4.37e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446395008 107 YVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLFLVK 161
Cdd:PRK14042 540 HVSAGDEVKAGQAVLVIEAMKMETEIKAPANGVVAEILCQKGDKVTPGQVLIRVE 594
Tegument_dsDNA pfam12818
dsDNA viral tegument protein; This is a family of tegument proteins from double-stranded DNA ...
 92-129 3.73e-04

dsDNA viral tegument protein; This is a family of tegument proteins from double-stranded DNA herpesvirus and related viral species.


Pssm-ID: 289579  Cd Length: 277  Bit Score: 39.36  E-value: 3.73e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 446395008   92 MVGTFYSSSSPDTPPYVSvgdRVSKDSIVCIVEAMKLF 129
Cdd:pfam12818 124 ALGQFYPTSGPDTPPYLY---RDSSDDYNRVVQALNLF 158
PDHac_trf_long TIGR01348
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model ...
 42-154 4.11e-04

pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model describes a subset of pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase specifically close by both phylogenetic and per cent identity (UPGMA) trees. Members of this set include two or three copies of the lipoyl-binding domain. E. coli AceF is a member of this model, while mitochondrial and some other bacterial forms belong to a separate model. [Energy metabolism, Pyruvate dehydrogenase]


Pssm-ID: 273566 [Multi-domain]  Cd Length: 546  Bit Score: 39.47  E-value: 4.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446395008   42 AVQAPAAKQAMQPVAPVEVETTVAAAQAEAPKQEEKKTVQDenlhkITSPMVGTFysSSSPDTPPYVSVGDRVSKDSIVC 121
Cdd:TIGR01348  78 GAQAQAEAKKEAAPAPTAGAPAPAAQAQAAPAAGQSSGVQE-----VTVPDIGDI--EKVTVIEVLVKVGDTVSADQSLI 150

                          90       100       110
                  ....*....|....*....|....*....|...
gi 446395008  122 IVEAMKLFNEIDADVEGEIVEILVNNGQLVEYG 154
Cdd:TIGR01348 151 TLESDKASMEVPAPASGVVKSVKVKVGDSVPTG 183
sucB TIGR01347
2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This ...
 110-160 4.97e-04

2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This model describes the TCA cycle 2-oxoglutarate system E2 component, dihydrolipoamide succinyltransferase. It is closely related to the pyruvate dehydrogenase E2 component, dihydrolipoamide acetyltransferase. The seed for this model includes mitochondrial and Gram-negative bacterial forms. Mycobacterial candidates are highly derived, differ in having and extra copy of the lipoyl-binding domain at the N-terminus. They score below the trusted cutoff, but above the noise cutoff and above all examples of dihydrolipoamide acetyltransferase. [Energy metabolism, TCA cycle]


Pssm-ID: 273565 [Multi-domain]  Cd Length: 403  Bit Score: 39.33  E-value: 4.97e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 446395008  110 VGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLFLV 160
Cdd:TIGR01347  24 VGDTVKRDENIVEIETDKVVLEVPSPADGVLQEILFKEGDTVESGQVLAIL 74
PHA03366 PHA03366
FGAM-synthase; Provisional
 92-129 1.42e-03

FGAM-synthase; Provisional


Pssm-ID: 223058 [Multi-domain]  Cd Length: 1304  Bit Score: 38.08  E-value: 1.42e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 446395008   92 MVGTFYSSSSPDTPPYVSvgdRVSKDSIVCIVEAMKLF 129
Cdd:PHA03366  380 ALGSFEPSSGPDTPPYLY---RDSGLEANKILQALKLF 414
PRK08225 PRK08225
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 85-157 1.62e-03

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 181304 [Multi-domain]  Cd Length: 70  Bit Score: 35.53  E-value: 1.62e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446395008  85 LHKITSPMVGTFYSSsspdtppYVSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPL 157
Cdd:PRK08225   1 MTKVYASMAGNVWKI-------VVKVGDTVEEGQDVVILESMKMEIPIVAEEAGTVKKINVQEGDFVNEGDVL 66
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 108-162 4.12e-03

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 36.72  E-value: 4.12e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446395008 108 VSVGDRVSKDSIVCIVEAMKLFNEIDADVEGEIVEILVNNGQLVEYGQPLFLVKA 162
Cdd:PRK11855  23 VKEGDTVEEDQPLVTVETDKATMEIPSPAAGVVKEIKVKVGDTVSVGGLLAVIEA 77
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
132-158 9.52e-03

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 35.41  E-value: 9.52e-03
                         10        20
                 ....*....|....*....|....*..
gi 446395008 132 IDADVEGEIVEILVNNGQLVEYGQPLF 158
Cdd:COG1566   48 VAAKVSGRVTEVLVKEGDRVKKGQVLA 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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