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Conserved domains on  [gi|446397306|ref|WP_000475161|]
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MULTISPECIES: ankyrin repeat domain-containing protein [Bacillus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-226 1.03e-44

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 150.87  E-value: 1.03e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  30 NMETALLTATEKQETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGY 109
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 110 LDILKLTIDAGADPTLTNRYGGTALIPASEHGYIDVIKELLTRtNIDVNHVNNLGWTALMEAIVLSNGDetqqqVIRLLI 189
Cdd:COG0666  166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDLAAENGNLE-----IVKLLL 239

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 446397306 190 EHGADVNIPDNDGVTPLEHARAHHFKEIEKILLEEHK 226
Cdd:COG0666  240 EAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALL 276
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-226 1.03e-44

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 150.87  E-value: 1.03e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  30 NMETALLTATEKQETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGY 109
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 110 LDILKLTIDAGADPTLTNRYGGTALIPASEHGYIDVIKELLTRtNIDVNHVNNLGWTALMEAIVLSNGDetqqqVIRLLI 189
Cdd:COG0666  166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDLAAENGNLE-----IVKLLL 239

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 446397306 190 EHGADVNIPDNDGVTPLEHARAHHFKEIEKILLEEHK 226
Cdd:COG0666  240 EAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALL 276
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 35-223 5.91e-22

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 92.81  E-value: 5.91e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  35 LLTATEKQETNTVISLLKKGADINITDNKGRTPLMIATY-----KNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAE-- 107
Cdd:PHA03100  39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNikynlTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKks 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 108 GYLDILKLTIDAGADPTLTNRYGGTALIPASEHGYID--VIKELLTRT---------------NIDVNHVNNLGWTALME 170
Cdd:PHA03100 119 NSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGvdinaknrvnyllsyGVPINIKDVYGFTPLHY 198

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446397306 171 AIVLSNGDetqqqVIRLLIEHGADVNIPDNDGVTPLEHARAHHFKEIEKILLE 223
Cdd:PHA03100 199 AVYNNNPE-----FVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246
Ank_2 pfam12796
Ankyrin repeats (3 copies);
101-199 1.03e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 1.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  101 FLYAGAEGYLDILKLTIDAGADPTLTNRYGGTALIPASEHGYIDVIKELLTRTNIDvnhVNNLGWTALMEAIVLSNGDet 180
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARSGHLE-- 75

                          90
                  ....*....|....*....
gi 446397306  181 qqqVIRLLIEHGADVNIPD 199
Cdd:pfam12796  76 ---IVKLLLEKGADINVKD 91
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 63-134 2.61e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 44.62  E-value: 2.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  63 KGRTPLMIATYKNDVKTAKALIEAGADVN--------IQDDMKN------NPFLYAGAEGYLDILKLTIDAGADPTLTNR 128
Cdd:cd22192   88 QGETALHIAVVNQNLNLVRELIARGADVVspratgtfFRPGPKNliyygeHPLSFAACVGNEEIVRLLIEHGADIRAQDS 167


                 ....*.
gi 446397306 129 YGGTAL 134
Cdd:cd22192  168 LGNTVL 173
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 63-92 4.63e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 4.63e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 446397306    63 KGRTPLMIATYKNDVKTAKALIEAGADVNI 92
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-226 1.03e-44

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 150.87  E-value: 1.03e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  30 NMETALLTATEKQETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGY 109
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 110 LDILKLTIDAGADPTLTNRYGGTALIPASEHGYIDVIKELLTRtNIDVNHVNNLGWTALMEAIVLSNGDetqqqVIRLLI 189
Cdd:COG0666  166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDLAAENGNLE-----IVKLLL 239

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 446397306 190 EHGADVNIPDNDGVTPLEHARAHHFKEIEKILLEEHK 226
Cdd:COG0666  240 EAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALL 276
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
24-226 1.56e-42

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 145.48  E-value: 1.56e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  24 VKKEMINMETALLTATEKQETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLY 103
Cdd:COG0666   47 LALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 104 AGAEGYLDILKLTIDAGADPTLTNRYGGTALIPASEHGYIDVIKELLTRtNIDVNHVNNLGWTALMEAIVLSNGDetqqq 183
Cdd:COG0666  127 AAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA-GADVNARDNDGETPLHLAAENGHLE----- 200

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446397306 184 VIRLLIEHGADVNIPDNDGVTPLEHARAHHFKEIEKILLEEHK 226
Cdd:COG0666  201 IVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA 243
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
29-223 3.54e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 121.21  E-value: 3.54e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  29 INMETALLTATEKQETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEG 108
Cdd:COG0666   19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 109 YLDILKLTIDAGADPTLTNRYGGTALIPASEHGYIDVIKELLTRtNIDVNHVNNLGWTALMEAIvlSNGDEtqqQVIRLL 188
Cdd:COG0666   99 DLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA-GADVNAQDNDGNTPLHLAA--ANGNL---EIVKLL 172

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 446397306 189 IEHGADVNIPDNDGVTPLEHARAHHFKEIEKILLE 223
Cdd:COG0666  173 LEAGADVNARDNDGETPLHLAAENGHLEIVKLLLE 207
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-201 3.33e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.52  E-value: 3.33e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  32 ETALLTATEKQETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLD 111
Cdd:COG0666  121 ETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLE 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 112 ILKLTIDAGADPTLTNRYGGTALIPASEHGYIDVIKELLTRtNIDVNHVNNLGWTALMEAIVLSNGDETQQQVIRLLIEH 191
Cdd:COG0666  201 IVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA-GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLA 279

                        170
                 ....*....|
gi 446397306 192 GADVNIPDND 201
Cdd:COG0666  280 AALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-167 3.47e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 94.64  E-value: 3.47e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  30 NMETALLTATEKQETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGY 109
Cdd:COG0666  152 DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGN 231

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446397306 110 LDILKLTIDAGADPTLTNRYGGTALIPASEHGYIDVIKELLTRTNIDVNHVNNLGWTA 167
Cdd:COG0666  232 LEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-223 2.05e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 92.32  E-value: 2.05e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  47 VISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLDILKLTIDAGADPTLT 126
Cdd:COG0666    4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 127 NRYGGTALIPASEHGYIDVIKELLTRtNIDVNHVNNLGWTALMEAIvlSNGDEtqqQVIRLLIEHGADVNIPDNDGVTPL 206
Cdd:COG0666   84 DDGGNTLLHAAARNGDLEIVKLLLEA-GADVNARDKDGETPLHLAA--YNGNL---EIVKLLLEAGADVNAQDNDGNTPL 157

                        170
                 ....*....|....*..
gi 446397306 207 EHARAHHFKEIEKILLE 223
Cdd:COG0666  158 HLAAANGNLEIVKLLLE 174
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 35-223 5.91e-22

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 92.81  E-value: 5.91e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  35 LLTATEKQETNTVISLLKKGADINITDNKGRTPLMIATY-----KNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAE-- 107
Cdd:PHA03100  39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNikynlTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKks 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 108 GYLDILKLTIDAGADPTLTNRYGGTALIPASEHGYID--VIKELLTRT---------------NIDVNHVNNLGWTALME 170
Cdd:PHA03100 119 NSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGvdinaknrvnyllsyGVPINIKDVYGFTPLHY 198

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446397306 171 AIVLSNGDetqqqVIRLLIEHGADVNIPDNDGVTPLEHARAHHFKEIEKILLE 223
Cdd:PHA03100 199 AVYNNNPE-----FVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246
PHA03095 PHA03095
ankyrin-like protein; Provisional
 27-208 9.29e-22

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 92.78  E-value: 9.29e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  27 EMINMETALLTATEKQETNTVI---SLLKKGADINITDNKGRTPL---MIATYKNDVKTAKALIEAGADVNIQDDMKNNP 100
Cdd:PHA03095   7 VDIIMEAALYDYLLNASNVTVEevrRLLAAGADVNFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTP 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 101 F-LYAGAEGYLDILKLTIDAGADPTLTNRYGGTALipaseHGYI-------DVIKELLtRTNIDVNHVNNLGWTALmeAI 172
Cdd:PHA03095  87 LhLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPL-----HVYLsgfninpKVIRLLL-RKGADVNALDLYGMTPL--AV 158

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 446397306 173 VLSNGDETqQQVIRLLIEHGADVNIPDNDGVTPLEH 208
Cdd:PHA03095 159 LLKSRNAN-VELLRLLIDAGADVYAVDDRFRSLLHH 193
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 43-209 1.12e-21

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 92.33  E-value: 1.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  43 ETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLDILKLTIDAGAD 122
Cdd:PHA02874 103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 123 PTLTNRYGGTALIPASEHGYIDVIKELLTRTNIDVNHVNNlGWTALMEAIVLSngdetqQQVIRLLIEHgADVNIPDNDG 202
Cdd:PHA02874 183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKN-GFTPLHNAIIHN------RSAIELLINN-ASINDQDIDG 254


                 ....*..
gi 446397306 203 VTPLEHA 209
Cdd:PHA02874 255 STPLHHA 261
PHA03095 PHA03095
ankyrin-like protein; Provisional
 44-213 4.19e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 85.08  E-value: 4.19e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  44 TNTVISLLKKGADINITDNKGRTPLMIATyKN---DVKTAKALIEAGADVNIQDDMKNNPF----LYAGAegYLDILKLT 116
Cdd:PHA03095 132 PKVIRLLLRKGADVNALDLYGMTPLAVLL-KSrnaNVELLRLLIDAGADVYAVDDRFRSLLhhhlQSFKP--RARIVREL 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 117 IDAGADPTLTNRYGGTALIPASEHGYIDVIKEL-LTRTNIDVNHVNNLGWTALMEAIVLSNgdetqQQVIRLLIEHGADV 195
Cdd:PHA03095 209 IRAGCDPAATDMLGNTPLHSMATGSSCKRSLVLpLLIAGISINARNRYGQTPLHYAAVFNN-----PRACRRLIALGADI 283

                        170
                 ....*....|....*...
gi 446397306 196 NIPDNDGVTPLEHARAHH 213
Cdd:PHA03095 284 NAVSSDGNTPLSLMVRNN 301
PHA03095 PHA03095
ankyrin-like protein; Provisional
 50-212 5.86e-18

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 81.61  E-value: 5.86e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  50 LLKKGADINITDNKGRTPLMI-ATYKN-DVKTAKALIEAGADVNIQDDMKNNP---FL-YAGAEgyLDILKLTIDAGADP 123
Cdd:PHA03095 103 LIKAGADVNAKDKVGRTPLHVyLSGFNiNPKVIRLLLRKGADVNALDLYGMTPlavLLkSRNAN--VELLRLLIDAGADV 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 124 TLTNRYGGTAL--IPASEHGYIDVIKElLTRTNIDVNHVNNLGWTALMeaiVLSNGDETQQQVIRLLIEHGADVNIPDND 201
Cdd:PHA03095 181 YAVDDRFRSLLhhHLQSFKPRARIVRE-LIRAGCDPAATDMLGNTPLH---SMATGSSCKRSLVLPLLIAGISINARNRY 256

                        170
                 ....*....|.
gi 446397306 202 GVTPLEHARAH 212
Cdd:PHA03095 257 GQTPLHYAAVF 267
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 43-209 1.44e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 77.61  E-value: 1.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  43 ETNTVISLLKKGADINITD-NKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLDILKLTIDAGA 121
Cdd:PHA02878 146 EAEITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 122 DPTLTNRYGGTAL-IPASEHGYIDVIKELLTRtNIDVNHVNN-LGWTALMEAIvlsngdeTQQQVIRLLIEHGADVNIPD 199
Cdd:PHA02878 226 STDARDKCGNTPLhISVGYCKDYDILKLLLEH-GVDVNAKSYiLGLTALHSSI-------KSERKLKLLLEYGADINSLN 297

                        170
                 ....*....|
gi 446397306 200 NDGVTPLEHA 209
Cdd:PHA02878 298 SYKLTPLSSA 307
Ank_2 pfam12796
Ankyrin repeats (3 copies);
101-199 1.03e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 1.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  101 FLYAGAEGYLDILKLTIDAGADPTLTNRYGGTALIPASEHGYIDVIKELLTRTNIDvnhVNNLGWTALMEAIVLSNGDet 180
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARSGHLE-- 75

                          90
                  ....*....|....*....
gi 446397306  181 qqqVIRLLIEHGADVNIPD 199
Cdd:pfam12796  76 ---IVKLLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 31-219 1.28e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 75.00  E-value: 1.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  31 METALLTATEKQETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYL 110
Cdd:PHA02874 124 LKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDY 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 111 DILKLTIDAGADPTLTNRYGGTALIPASEHGYiDVIKELLTRTNIDVNHVNnlGWTALMEAIvlsnGDETQQQVIRLLIE 190
Cdd:PHA02874 204 ACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLINNASINDQDID--GSTPLHHAI----NPPCDIDIIDILLY 276

                        170       180
                 ....*....|....*....|....*....
gi 446397306 191 HGADVNIPDNDGVTPLEHArahhFKEIEK 219
Cdd:PHA02874 277 HKADISIKDNKGENPIDTA----FKYINK 301
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 53-224 1.37e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 75.00  E-value: 1.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  53 KGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLDILKLTIDAGADPTLTNryggt 132
Cdd:PHA02874  24 KGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILP----- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 133 alIPASEHGYIDVIKElltrTNIDVNHVNNLGWTALMEAIvlSNGDetqQQVIRLLIEHGADVNIPDNDGVTPLEHARAH 212
Cdd:PHA02874  99 --IPCIEKDMIKTILD----CGIDVNIKDAELKTFLHYAI--KKGD---LESIKMLFEYGADVNIEDDNGCYPIHIAIKH 167

                        170
                 ....*....|..
gi 446397306 213 HFKEIEKILLEE 224
Cdd:PHA02874 168 NFFDIIKLLLEK 179
Ank_2 pfam12796
Ankyrin repeats (3 copies);
35-127 1.41e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.98  E-value: 1.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306   35 LLTATEKQETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEaGADVNIQDDmKNNPFLYAGAEGYLDILK 114
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 446397306  115 LTIDAGADPTLTN 127
Cdd:pfam12796  79 LLLEKGADINVKD 91
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 30-207 2.23e-13

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 68.74  E-value: 2.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  30 NMETALLTATEKQETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGY 109
Cdd:PLN03192 524 NMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKH 603

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 110 LDILKLT--IDAGADPtltnRYGGTALIPASEHGYIDVIKELLtRTNIDVNHVNNLGWTALMEAIVlsngdETQQQVIRL 187
Cdd:PLN03192 604 HKIFRILyhFASISDP----HAAGDLLCTAAKRNDLTAMKELL-KQGLNVDSEDHQGATALQVAMA-----EDHVDMVRL 673

                        170       180
                 ....*....|....*....|.
gi 446397306 188 LIEHGADVNIPD-NDGVTPLE 207
Cdd:PLN03192 674 LIMNGADVDKANtDDDFSPTE 694
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 33-152 2.08e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 65.40  E-value: 2.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  33 TALLTATEKQETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLDI 112
Cdd:PHA02875 104 TPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAI 183

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446397306 113 LKLTIDAGADPTLTNRYGG-TALIPASEHGYIDVIKELLTR 152
Cdd:PHA02875 184 CKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKR 224
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 35-162 1.39e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.15  E-value: 1.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  35 LLTATEKQETNTVIS-LLKKGADINITDNKGRTPLMIATY--KNDVKTAKALIEAGADVN----------------IQDD 95
Cdd:PHA03100 111 LYAISKKSNSYSIVEyLLDNGANVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKGVDINaknrvnyllsygvpinIKDV 190

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446397306  96 MKNNPFLYAGAEGYLDILKLTIDAGADPTLTNRYGGTALIPASEHGYIDVIKELLtRTNIDVNHVNN 162
Cdd:PHA03100 191 YGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLL-NNGPSIKTIIE 256
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 30-197 5.43e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 61.16  E-value: 5.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  30 NMETALLTATEKQETNTVISLLKKGADIN-ITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEG 108
Cdd:PHA02875  67 DIESELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMG 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 109 YLDILKLTIDAGADPTLTNRYGGTALIPASEHGYIDVIKELLTrTNIDVNHVNNLGWTALMEAIVLSNgdetQQQVIRLL 188
Cdd:PHA02875 147 DIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD-SGANIDYFGKNGCVAALCYAIENN----KIDIVRLF 221


                 ....*....
gi 446397306 189 IEHGADVNI 197
Cdd:PHA02875 222 IKRGADCNI 230
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 23-222 6.70e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 61.23  E-value: 6.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  23 EVKKEMINMETAL-LTATEKQETNTVISLLKKGADINITDNKGRTPLMIAT----YKNDVKTakaLIEAGADVNIQDDMK 97
Cdd:PHA02876 299 DVNAKNIKGETPLyLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQAStldrNKDIVIT---LLELGANVNARDYCD 375

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  98 NNPFLYAGAEGYLDILKLTIDAGADPTLTNRYGGTALIPA--SEHGYIDViKELLTRtNIDVNHVNNLGWTALMEAIvls 175
Cdd:PHA02876 376 KTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlcGTNPYMSV-KTLIDR-GANVNSKNKDLSTPLHYAC--- 450

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 446397306 176 nGDETQQQVIRLLIEHGADVNIPDNDGVTPLEHARAHHfkEIEKILL 222
Cdd:PHA02876 451 -KKNCKLDVIEMLLDNGADVNAINIQNQYPLLIALEYH--GIVNILL 494
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 47-223 8.55e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 60.85  E-value: 8.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  47 VISLLKKGADINITDNKGRTPL-MIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGA-EGYLDILKLTIDAGADPT 124
Cdd:PHA02876 290 VPKLLERGADVNAKNIKGETPLyLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVN 369

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 125 LTNRYGGTALIPASEHGYIDVIKELLTrTNIDVNHVNNLGWTALMEAIVLSNgdetQQQVIRLLIEHGADVNIPDNDGVT 204
Cdd:PHA02876 370 ARDYCDKTPIHYAAVRNNVVIINTLLD-YGADIEALSQKIGTALHFALCGTN----PYMSVKTLIDRGANVNSKNKDLST 444

                        170       180
                 ....*....|....*....|
gi 446397306 205 PLEHARAHHFK-EIEKILLE 223
Cdd:PHA02876 445 PLHYACKKNCKlDVIEMLLD 464
PHA02798 PHA02798
ankyrin-like protein; Provisional
 44-200 1.16e-10

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 60.62  E-value: 1.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  44 TNTVISLLKKGADINITDNKGRTPLM-----IATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGY---LDILKL 115
Cdd:PHA02798  51 TDIVKLFINLGANVNGLDNEYSTPLCtilsnIKDYKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGYinnLEILLF 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 116 TIDAGADPTLTNRYGGTAL---IPASEHGYIDVIKeLLTRTNIDVNHVNNLGWTALMEAIVLSNGDETQQQVIRLLIEHG 192
Cdd:PHA02798 131 MIENGADTTLLDKDGFTMLqvyLQSNHHIDIEIIK-LLLEKGVDINTHNNKEKYDTLHCYFKYNIDRIDADILKLFVDNG 209


                 ....*...
gi 446397306 193 ADVNIPDN 200
Cdd:PHA02798 210 FIINKENK 217
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 23-223 2.60e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 59.69  E-value: 2.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  23 EVKKEMINMETALLTATEKQETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNiQDDMKnnpFL 102
Cdd:PHA02876 170 DVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNIN-KNDLS---LL 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 103 YAGAEGYLDILKLTIDAGADPTLTNRYGGTALIPASEHGYIDVIKELLTRTNIDVNHVNNLGWTALMeaIVLSNGDETQQ 182
Cdd:PHA02876 246 KAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLY--LMAKNGYDTEN 323

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 446397306 183 qvIRLLIEHGADVNIPDNDGVTPLEHARA-HHFKEIEKILLE 223
Cdd:PHA02876 324 --IRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLE 363
Ank_2 pfam12796
Ankyrin repeats (3 copies);
32-94 8.54e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 8.54e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446397306   32 ETALLTATEKQETNTVISLLKKgADINITDNkGRTPLMIATYKNDVKTAKALIEAGADVNIQD 94
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
137-223 8.90e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 8.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  137 ASEHGYIDVIKELLTRtNIDVNHVNNLGWTALMEAIvlSNGdetQQQVIRLLIEHgADVNIpDNDGVTPLEHARAHHFKE 216
Cdd:pfam12796   4 AAKNGNLELVKLLLEN-GADANLQDKNGRTALHLAA--KNG---HLEIVKLLLEH-ADVNL-KDNGRTALHYAARSGHLE 75


                  ....*..
gi 446397306  217 IEKILLE 223
Cdd:pfam12796  76 IVKLLLE 82
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 50-140 3.89e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.98  E-value: 3.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  50 LLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLDILKL---------TIDAG 120
Cdd:PTZ00322 101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLlsrhsqchfELGAN 180

                         90       100
                 ....*....|....*....|.
gi 446397306 121 ADP-TLTNRYGGTALIPASEH 140
Cdd:PTZ00322 181 AKPdSFTGKPPSLEDSPISSH 201
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 38-223 3.60e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.88  E-value: 3.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  38 ATEKQETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEagadVNIQDDMKNNPFLYAGAEGYLDILKLTI 117
Cdd:PHA02878  44 AVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIR----SINKCSVFYTLVAIKDAFNNRNVEIFKI 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 118 dagadpTLTNRYGG---TALIPASEHGYIDVIKELLTRT----NIDVNHVN-NLGWTALMEAivlsnGDETQQQVIRLLI 189
Cdd:PHA02878 120 ------ILTNRYKNiqtIDLVYIDKKSKDDIIEAEITKLllsyGADINMKDrHKGNTALHYA-----TENKDQRLTELLL 188

                        170       180       190
                 ....*....|....*....|....*....|....
gi 446397306 190 EHGADVNIPDNDGVTPLEHARAHHFKEIEKILLE 223
Cdd:PHA02878 189 SYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLE 222
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 76-152 6.02e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 6.02e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446397306  76 DVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLDILKLTIDAGADPTLTNRYGGTALIPASEHGYIDVIkELLTR 152
Cdd:PTZ00322  94 DAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV-QLLSR 169
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 38-195 1.30e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.52  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  38 ATEKQETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYA--GAEGYLDIlKL 115
Cdd:PHA02876 349 STLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlcGTNPYMSV-KT 427

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 116 TIDAGADPTLTNRYGGTALIPASEHG-YIDVIKELLTrTNIDVNHVNNLGWTALMEAIvlsngdeTQQQVIRLLIEHGAD 194
Cdd:PHA02876 428 LIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLD-NGADVNAINIQNQYPLLIAL-------EYHGIVNILLHYGAE 499


                 .
gi 446397306 195 V 195
Cdd:PHA02876 500 L 500
Ank_4 pfam13637
Ankyrin repeats (many copies);
64-115 2.58e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.42  E-value: 2.58e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446397306   64 GRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLDILKL 115
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKL 52
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 32-92 2.82e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 47.35  E-value: 2.82e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446397306  32 ETALLTATEKQETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNI 92
Cdd:PHA03100 193 FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
Ank_4 pfam13637
Ankyrin repeats (many copies);
98-150 2.94e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.03  E-value: 2.94e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 446397306   98 NNPFLYAGAEGYLDILKLTIDAGADPTLTNRYGGTALIPASEHGYIDVIKELL 150
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
149-209 5.24e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 5.24e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446397306  149 LLTRTNIDVNHVNNLGWTALMEAIvlSNGDetqQQVIRLLIEHGADVNIPDNDGVTPLEHA 209
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAA--KYGA---LEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 30-223 1.06e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 45.75  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  30 NMETALLTATEKQETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGY 109
Cdd:PHA02875   1 MDQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 110 LDILKLTIDAG--ADPTLTNRyGGTALIPASEHGYIDVIKELLTRtNIDVNHVNNLGWTALMEAIVLSNgdetqQQVIRL 187
Cdd:PHA02875  81 VKAVEELLDLGkfADDVFYKD-GMTPLHLATILKKLDIMKLLIAR-GADPDIPNTDKFSPLHLAVMMGD-----IKGIEL 153

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 446397306 188 LIEHGADVNIPDNDGVTPLEHARAHHFKEIEKILLE 223
Cdd:PHA02875 154 LIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD 189
PHA03095 PHA03095
ankyrin-like protein; Provisional
 47-114 1.13e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.40  E-value: 1.13e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446397306  47 VISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLDILK 114
Cdd:PHA03095 240 VLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
Ank_4 pfam13637
Ankyrin repeats (many copies);
33-84 1.57e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 1.57e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446397306   33 TALLTATEKQETNTVISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALI 84
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 50-206 2.52e-05

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 44.52  E-value: 2.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  50 LLKKGADINITDNKGRTPLMIATYKNDVKTA--KALIEAGADVNIQDDMKNNPFL-YAGAEGYLD--ILKLTIDAGADPT 124
Cdd:PHA02716 198 LCNNGVNVNLQNNHLITPLHTYLITGNVCASviKKIIELGGDMDMKCVNGMSPIMtYIINIDNINpeITNIYIESLDGNK 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 125 LTNryggtalIPASEHGYI--------DVIKELLtRTNIDVNHVNNLGWTALMEAIVLSNgdeTQQQVIRLLIEHGADVN 196
Cdd:PHA02716 278 VKN-------IPMILHSYItlarnidiSVVYSFL-QPGVKLHYKDSAGRTCLHQYILRHN---ISTDIIKLLHEYGNDLN 346

                        170
                 ....*....|
gi 446397306 197 IPDNDGVTPL 206
Cdd:PHA02716 347 EPDNIGNTVL 356
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 63-134 2.61e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 44.62  E-value: 2.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  63 KGRTPLMIATYKNDVKTAKALIEAGADVN--------IQDDMKN------NPFLYAGAEGYLDILKLTIDAGADPTLTNR 128
Cdd:cd22192   88 QGETALHIAVVNQNLNLVRELIARGADVVspratgtfFRPGPKNliyygeHPLSFAACVGNEEIVRLLIEHGADIRAQDS 167


                 ....*.
gi 446397306 129 YGGTAL 134
Cdd:cd22192  168 LGNTVL 173
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 63-95 3.28e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 3.28e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 446397306   63 KGRTPLMIATYK-NDVKTAKALIEAGADVNIQDD 95
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank_5 pfam13857
Ankyrin repeats (many copies);
50-104 6.01e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.64  E-value: 6.01e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 446397306   50 LLKKG-ADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYA 104
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 183-222 1.12e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.58  E-value: 1.12e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 446397306 183 QVIRLLIEHGADVNIPDNDGVTPLEHARAHHFKEIEKILL 222
Cdd:PTZ00322 129 QVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
Ank_4 pfam13637
Ankyrin repeats (many copies);
164-222 1.32e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 1.32e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446397306  164 GWTALMEAIVLSNgdetqQQVIRLLIEHGADVNIPDNDGVTPLEHARAHHFKEIEKILL 222
Cdd:pfam13637   1 ELTALHAAAASGH-----LELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 164-200 1.35e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 1.35e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 446397306  164 GWTALMEAIVLSNgdetQQQVIRLLIEHGADVNIPDN 200
Cdd:pfam00023   2 GNTPLHLAAGRRG----NLEIVKLLLSKGADVNARDK 34
PHA02946 PHA02946
ankyin-like protein; Provisional
 47-222 2.33e-04

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.58  E-value: 2.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  47 VISLLKKGADINITDNKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGA--EGYLDILKLTIDAGADPT 124
Cdd:PHA02946  55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGtdDEVIERINLLVQYGAKIN 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 125 LTNRYGGTALIPASEHGYIDVIKELLTrTNIDVNHVNNLGWTALMEAIVlsnGDETQQQVIRLLIEHGADVNIPDNDGVT 204
Cdd:PHA02946 135 NSVDEEGCGPLLACTDPSERVFKKIMS-IGFEARIVDKFGKNHIHRHLM---SDNPKASTISWMMKLGISPSKPDHDGNT 210

                        170
                 ....*....|....*...
gi 446397306 205 PLEHARAHHFKEIEKILL 222
Cdd:PHA02946 211 PLHIVCSKTVKNVDIINL 228
PHA02798 PHA02798
ankyrin-like protein; Provisional
 41-223 3.68e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 40.97  E-value: 3.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  41 KQETNTVISLLKKGADINITDNKGRTP---LMIATYKNDVKTAKALIEAGADVNIQDDMKNNP---FLYAGAEGYLDILK 114
Cdd:PHA02798  86 KHMLDIVKILIENGADINKKNSDGETPlycLLSNGYINNLEILLFMIENGADTTLLDKDGFTMlqvYLQSNHHIDIEIIK 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 115 LTIDAGAD-PTLTNRYGGTALIPASEHGY--IDV-IKELLTRTNIDVNHVNNLGWTALMEAIV--LSNGDETQQQVIRLL 188
Cdd:PHA02798 166 LLLEKGVDiNTHNNKEKYDTLHCYFKYNIdrIDAdILKLFVDNGFIINKENKSHKKKFMEYLNslLYDNKRFKKNILDFI 245

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 446397306 189 IEHgADVNIPDNDGVTPLEHARAHHFKEIEKILLE 223
Cdd:PHA02798 246 FSY-IDINQVDELGFNPLYYSVSHNNRKIFEYLLQ 279
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 63-92 4.63e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 4.63e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 446397306    63 KGRTPLMIATYKNDVKTAKALIEAGADVNI 92
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 43-195 6.37e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 40.11  E-value: 6.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  43 ETNTVISLLKKGADINiTDNKGRTPLMIATYKNDVKT--AKALIEAGADVNIQDDMK-------NNpfLYAGAEGYLDIL 113
Cdd:PHA02989  15 DKNALEFLLRTGFDVN-EEYRGNSILLLYLKRKDVKIkiVKLLIDNGADVNYKGYIEtplcavlRN--REITSNKIKKIV 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 114 KLTIDAGADPTLTNRYGGTALIPASEHGYIDV--IKELLTRTNIDVNHVNNLGWTALMEAIVlsNGDETQQQVIRLLIEH 191
Cdd:PHA02989  92 KLLLKFGADINLKTFNGVSPIVCFIYNSNINNcdMLRFLLSKGINVNDVKNSRGYNLLHMYL--ESFSVKKDVIKILLSF 169


                 ....
gi 446397306 192 GADV 195
Cdd:PHA02989 170 GVNL 173
Ank_4 pfam13637
Ankyrin repeats (many copies);
130-189 6.69e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 6.69e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  130 GGTALIPASEHGYIDVIKELLtRTNIDVNHVNNLGWTALMEAIvlSNGDEtqqQVIRLLI 189
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLL-EKGADINAVDGNGETALHFAA--SNGNV---EVLKLLL 54
PHA02798 PHA02798
ankyrin-like protein; Provisional
 110-223 7.97e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 39.82  E-value: 7.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306 110 LDILKLTIDAGADPT-LTNRYGG---TALIPASEHGY-IDVIKeLLTRTNIDVNHVNNLGWTALMeaIVLSNGDETQQQV 184
Cdd:PHA02798  51 TDIVKLFINLGANVNgLDNEYSTplcTILSNIKDYKHmLDIVK-ILIENGADINKKNSDGETPLY--CLLSNGYINNLEI 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 446397306 185 IRLLIEHGADVNIPDNDGVTPLE-HARAHHFKEIE--KILLE 223
Cdd:PHA02798 128 LLFMIENGADTTLLDKDGFTMLQvYLQSNHHIDIEiiKLLLE 169
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 81-207 8.51e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 39.03  E-value: 8.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  81 KALIEAGADVNIQDDMKN----NPFLYAGAEGYLDILKLTIDAGADPTLTNRYGGTALipaseHGY-------IDVIKEL 149
Cdd:PHA02859  70 KFLIENGADVNFKTRDNNlsalHHYLSFNKNVEPEILKILIDSGSSITEEDEDGKNLL-----HMYmcnfnvrINVIKLL 144

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446397306 150 L----TRTNIDvNHVNNLGWTALMEaivlsngdETQQQVIRLLIEHGADVNIPDNDGVTPLE 207
Cdd:PHA02859 145 IdsgvSFLNKD-FDNNNILYSYILF--------HSDKKIFDFLTSLGIDINETNKSGYNCYD 197
Ank_2 pfam12796
Ankyrin repeats (3 copies);
168-224 1.13e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.02  E-value: 1.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 446397306  168 LMEAIvlSNGDEtqqQVIRLLIEHGADVNIPDNDGVTPLEHARAHHFKEIEKILLEE 224
Cdd:pfam12796   1 LHLAA--KNGNL---ELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH 52
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 77-207 2.34e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 38.49  E-value: 2.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  77 VKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLDILKLTIDAGADPTLTNRYGGTALIPASEHGYI--DVIK--ELLTR 152
Cdd:PHA03100  15 VKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltDVKEivKLLLE 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446397306 153 TNIDVNHVNNLGWTALMEAIVLSNGDETqqqVIRLLIEHGADVNIPDNDGVTPLE 207
Cdd:PHA03100  95 YGANVNAPDNNGITPLLYAISKKSNSYS---IVEYLLDNGANVNIKNSDGENLLH 146
Ank_5 pfam13857
Ankyrin repeats (many copies);
83-134 2.78e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.01  E-value: 2.78e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 446397306   83 LIEAG-ADVNIQDDMKNNPFLYAGAEGYLDILKLTIDAGADPTLTNRYGGTAL 134
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 32-152 3.80e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 37.94  E-value: 3.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  32 ETALLTATEKQETNTVISLLKKGADINITDNK-------------GRTPLMIATYKNDVKTAKALIEAGAD---VNIQDD 95
Cdd:cd21882   74 QTALHIAIENRNLNLVRLLVENGADVSARATGrffrkspgnlfyfGELPLSLAACTNQEEIVRLLLENGAQpaaLEAQDS 153

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446397306  96 MKN------------NPFLYAGAEGYLDILkLTIDAGADPTL-----TNRYGGTALIPASEHGYIDVIKELLTR 152
Cdd:cd21882  154 LGNtvlhalvlqadnTPENSAFVCQMYNLL-LSYGAHLDPTQqleeiPNHQGLTPLKLAAVEGKIVMFQHILQR 226
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 26-152 3.96e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 37.86  E-value: 3.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  26 KEMINME---------TALLTATEKQETNTVISLLKKGADIN-------ITDNKGRT-------PLMIATYKNDVKTAKA 82
Cdd:cd22196   80 KEFVNAAytdsyykgqTALHIAIERRNMHLVELLVQNGADVHarasgefFKKKKGGPgfyfgelPLSLAACTNQLDIVKF 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  83 LIE---AGADVNIQDDMKNNPF--LYAGAEGYLDILK---------LTIDAGADPTL-----TNRYGGTALIPASEHGYI 143
Cdd:cd22196  160 LLEnphSPADISARDSMGNTVLhaLVEVADNTPENTKfvtkmyneiLILGAKIRPLLkleeiTNKKGLTPLKLAAKTGKI 239


                 ....*....
gi 446397306 144 DVIKELLTR 152
Cdd:cd22196  240 GIFAYILGR 248
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 63-92 5.17e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 33.77  E-value: 5.17e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 446397306   63 KGRTPLMIATYKNDVKTAKALIEAGADVNI 92
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 12-152 6.66e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 37.05  E-value: 6.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  12 VIFLQGCSQEQEVKKEMINME---------TALLTATEKQETNTVISLLKKGADINI---------TDNK-----GRTPL 68
Cdd:cd22194  113 VRILLAFAEENGILDRFINAEyteeayegqTALNIAIERRQGDIVKLLIAKGADVNAhakgvffnpKYKHegfyfGETPL 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446397306  69 MIATYKNDVKTAKALIEAGAD----------------VNIQDDMK-NNPFLyagAEGYLDILKLTIDAGADpTLTNRYGG 131
Cdd:cd22194  193 ALAACTNQPEIVQLLMEKESTditsqdsrgntvlhalVTVAEDSKtQNDFV---KRMYDMILLKSENKNLE-TIRNNEGL 268

                        170       180
                 ....*....|....*....|.
gi 446397306 132 TALIPASEHGYIDVIKELLTR 152
Cdd:cd22194  269 TPLQLAAKMGKAEILKYILSR 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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