|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
120-453 |
1.90e-49 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 173.20 E-value: 1.90e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 120 FALFVTGFFDNVTDNTVGINFKTKDGSIAVFMRPDIGETFSEFRTFLAVLLMLLLFISISLVIASTYSIIRPVKKLKLAT 199
Cdd:COG5002 45 LLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSEL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 200 ERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMRQHFVQNVSHEIKTPLTHIHHLLSELQQ--TSDKTLRQQY 277
Cdd:COG5002 125 LLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDgaADDPEERREY 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 278 --------------INDIYTITTqlsglttellllseLDNHQHLLFDDKIKVDQLIKDIIRHEQFAADEKSLIILADL-- 341
Cdd:COG5002 205 leiileeaerlsrlVNDLLDLSR--------------LESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLpe 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 342 ESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNSN--- 418
Cdd:COG5002 271 DPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSREtgg 350
|
330 340 350
....*....|....*....|....*....|....*..
gi 446399482 419 -GLGLAITKSIIELHHGTIQFTqSNEYV-TTFTITLP 453
Cdd:COG5002 351 tGLGLAIVKHIVEAHGGRIWVE-SEPGKgTTFTITLP 386
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
225-453 |
1.97e-47 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 163.15 E-value: 1.97e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 225 HFNKMRESLGQVDQMRQHFVQNVSHEIKTPLTHIHHLLSELQQTSDKT--LRQQYINDIYTITTQLSGLTTELLLLSELD 302
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSpeERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 303 NHQHLLFDDKIKVDQLIKDIIRHEQFAADEK--SLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQH 380
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKgiRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446399482 381 SHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNS--NGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEggTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
217-453 |
1.54e-45 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 161.23 E-value: 1.54e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 217 DEIGTLQYHFNKMRESLGQVDQMRQHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQqYINDIYTITTQLSGLTTELL 296
Cdd:COG0642 87 LLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQRE-YLETILRSADRLLRLINDLL 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 297 LLSELDNHQHLLFDDKIKVDQLIKDIIRHEQFAADEKSLIILADLES--INFLGNQRLLHQALSNLLINAIKYTDVGGAI 374
Cdd:COG0642 166 DLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDdlPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTV 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 375 DIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNSN--GLGLAITKSIIELHHGTIQFTQSNEYVTTFTITL 452
Cdd:COG0642 246 TVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGgtGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
|
.
gi 446399482 453 P 453
Cdd:COG0642 326 P 326
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
175-454 |
2.86e-31 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 125.34 E-value: 2.86e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 175 FISISLVIAS--TYSIIRPVKKLKLATERLIDGDfETPIKQTRKDEIGTLQYHFNKMRESL-GQvdQMRQHFVQNVSHEI 251
Cdd:PRK11100 191 LLGIALLIGAgvVWWLNRSIRRLTRYADAVTEGK-PVPLPKLGSSELRELAQALESMRVKLeGK--AYVEQYVQTLTHEL 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 252 KTPLTHIH---HLLSE--------------------LQQTSDKTLRQQYIndiytittqlsglttellllselDNHQHLL 308
Cdd:PRK11100 268 KSPLAAIRgaaELLQEdpppedrarftgniltqsarLQQLIDRLLELARL-----------------------EQRQELE 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 309 FDDKIKVDQLIKDIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFT 388
Cdd:PRK11100 325 VLEPVALAALLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALS 404
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446399482 389 ISNDGSPISPQAEARLFERFYKVSKHDN---SNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLPN 454
Cdd:PRK11100 405 VEDQGPGIPDYALPRIFERFYSLPRPANgrkSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
187-453 |
3.72e-31 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 124.75 E-value: 3.72e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 187 SIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMRQHFVQNVSHEIKTPLThihHLLSELQ 266
Cdd:PRK10549 187 GLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLA---VLRGELE 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 267 QTSDKtLRQ---QYIN----DIYTITtqlsglttelllLSELDNHQHLLFDD------KIKVD--QLIKDIIR--HEQFA 329
Cdd:PRK10549 264 AIQDG-VRKftpESVAslqaEVGTLT------------KLVDDLHQLSLSDEgalayrKTPVDlvPLLEVAGGafRERFA 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 330 AdeKSLIILADL-ESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISnDGSP-ISPQAEARLFER 407
Cdd:PRK10549 331 S--RGLTLQLSLpDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFA-DSAPgVSDEQLQKLFER 407
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 446399482 408 FYKVSKHDN----SNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:PRK10549 408 FYRTEGSRNrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELP 457
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
348-453 |
1.04e-29 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 111.59 E-value: 1.04e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 348 GNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNS---NGLGLAI 424
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKiggTGLGLSI 80
|
90 100
....*....|....*....|....*....
gi 446399482 425 TKSIIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
175-453 |
2.89e-29 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 118.91 E-value: 2.89e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 175 FISISLVIASTYSIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESL----GQVDQMRQHF---VQNV 247
Cdd:COG5000 20 LLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLkeqrEELEERRRYLetiLENL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 248 S------------------------------------------------------------------------------- 248
Cdd:COG5000 100 Pagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeeieltrdgrrtllvrasplrd 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 249 ------------------------------HEIKTPLTHIHHLLSELQQ------TSDKTLRQQYINdiyTITTQLsglt 292
Cdd:COG5000 180 dgyvivfdditellraerlaawgelarriaHEIKNPLTPIQLSAERLRRkladklEEDREDLERALD---TIIRQV---- 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 293 tellllseldnhQHL--LFDD-------------KIKVDQLIKDIIRHEQFAADEKSLIILADL--ESINFLGNQRLLHQ 355
Cdd:COG5000 253 ------------DRLkrIVDEfldfarlpepqlePVDLNELLREVLALYEPALKEKDIRLELDLdpDLPEVLADRDQLEQ 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 356 ALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYkvSKHDNSNGLGLAITKSIIELHHGT 435
Cdd:COG5000 321 VLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF--TTKPKGTGLGLAIVKKIVEEHGGT 398
|
410
....*....|....*...
gi 446399482 436 IQFTQSNEYVTTFTITLP 453
Cdd:COG5000 399 IELESRPGGGTTFTIRLP 416
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
175-453 |
7.32e-27 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 112.33 E-value: 7.32e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 175 FISISLVIASTYSIIRPVKKLKLATERLIDGDFEtpikQTRKDEIGTLQYH-----FNKMRESLGQVDQMRQHFVQNVSH 249
Cdd:PRK09470 177 LVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLR----QHPELETGPQEFRqagasFNQMVTALERMMTSQQRLLSDISH 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 250 EIKTPLTHIH---HLL-------SELQQTSDKTLR-QQYINDIYTITTQLSglttellllseldnHQHLLfDDKIKVDQL 318
Cdd:PRK09470 253 ELRTPLTRLQlatALLrrrqgesKELERIETEAQRlDSMINDLLVLSRNQQ--------------KNHLE-RETFKANSL 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 319 IKDIIRHEQFAADE--KSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDvgGAIDIALQHSHNNIIFTISNDGSPI 396
Cdd:PRK09470 318 WSEVLEDAKFEAEQmgKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSH--TKIEVAFSVDKDGLTITVDDDGPGV 395
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446399482 397 SPQAEARLFERFYKVS----KHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:PRK09470 396 PEEEREQIFRPFYRVDeardRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
190-453 |
7.70e-27 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 112.10 E-value: 7.70e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 190 RPVKKLKLATERLIDGDFETPIKQTRK-DEIGTLQYHFNKMRESLGQVDQMRQHFVQNVSHEIKTPLTHihhLLSELQQT 268
Cdd:TIGR01386 190 EPLRRLSAVAARISPESLDQRLDPSRApAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTN---LLGQTQVA 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 269 sdktLRQQYINDIYTITTQLSGLTTELLLLSELDnhqhLLFDDKIKVDQLIKDIIR---HEQFA---------ADEKSLI 336
Cdd:TIGR01386 267 ----LSQPRTGEEYREVLESNLEELERLSRMVSD----MLFLARADNGQLALERVRldlAAELAkvaeyfeplAEERGVR 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 337 ILADLESInFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKV--SKH 414
Cdd:TIGR01386 339 IRVEGEGL-VRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVdpARS 417
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 446399482 415 DNS--NGLGLAITKSIIELHHGTIQfTQSNEYVTTFTITLP 453
Cdd:TIGR01386 418 NSGegTGLGLAIVRSIMEAHGGRAS-AESPDGKTRFILRFP 457
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
348-453 |
1.59e-25 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 100.14 E-value: 1.59e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 348 GNQRLLHQALSNLLINAIKYTDVGGAIDIALqHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNS-NGLGLAITK 426
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTL-SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGgTGLGLSIVR 79
|
90 100
....*....|....*....|....*..
gi 446399482 427 SIIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:pfam02518 80 KLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
175-453 |
4.33e-25 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 107.55 E-value: 4.33e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 175 FIS---ISLVIASTYSIIRPVKKLKLATERLIDGDFETPIK-QTRKDEIGTLQYHFNKMRESLGQVDQMRQHFVQNVSHE 250
Cdd:PRK09835 193 VISlliVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDpQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHE 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 251 IKTPLTHihhLLSELQQTSDKTLRQQYIND-IYTIT---TQLSGLTTELLLLSELDNHQhlLFDDKIKVDqLIKDIIRHE 326
Cdd:PRK09835 273 IRTPITN---LITQTEIALSQSRSQKELEDvLYSNLeelTRMAKMVSDMLFLAQADNNQ--LIPEKKMLD-LADEVGKVF 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 327 QFA---ADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEAR 403
Cdd:PRK09835 347 DFFeawAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPR 426
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 446399482 404 LFERFYKV----SKHDNSNGLGLAITKSIIELHHGTIQfTQSNEYVTTFTITLP 453
Cdd:PRK09835 427 LFDRFYRVdpsrQRKGEGSGIGLAIVKSIVVAHKGTVA-VTSDARGTRFVISLP 479
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
235-454 |
1.09e-23 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 102.78 E-value: 1.09e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 235 QVDQMRQHFVQNVSHEIKTPLTHIHHLLSELQ-QTSDKTLRQQYINDIYTITTQLSGLTTELLLLSELDNHQHLLFDDKI 313
Cdd:PRK11006 199 QLEGARRNFFANVSHELRTPLTVLQGYLEMMQdQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKV 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 314 KVDQLIKDIIRHEQFAADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDG 393
Cdd:PRK11006 279 DVPMMLRVLEREAQTLSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNG 358
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446399482 394 SPISPQAEARLFERFYKV----SKHDNSNGLGLAITKSIIElHHGTIQFTQSNEYV-TTFTITLPN 454
Cdd:PRK11006 359 PGIAPEHIPRLTERFYRVdkarSRQTGGSGLGLAIVKHALS-HHDSRLEIESEVGKgTRFSFVLPE 423
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
241-457 |
4.31e-22 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 98.70 E-value: 4.31e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 241 QHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLR---QQYINDIYTITtqlsglttellllseldNHQHLLFDD------ 311
Cdd:COG4251 283 EQFAYVASHDLREPLRKISGFSQLLEEDYGDKLDeegREYLERIRDAA-----------------ERMQALIDDllaysr 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 312 ---------KIKVDQLIKDIIRHEQFAADEKSL-IILADLESINflGNQRLLHQALSNLLINAIKYTDVG--GAIDIALQ 379
Cdd:COG4251 346 vgrqelefePVDLNELLEEVLEDLEPRIEERGAeIEVGPLPTVR--GDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAE 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 380 HSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDN--SNGLGLAITKSIIELHHGTIQFtQSNEYV-TTFTITLPNNS 456
Cdd:COG4251 424 REGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEyeGTGIGLAIVKKIVERHGGRIWV-ESEPGEgATFYFTLPKAP 502
|
.
gi 446399482 457 H 457
Cdd:COG4251 503 A 503
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
221-453 |
1.79e-20 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 93.27 E-value: 1.79e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 221 TLQYHFNKMRESLGQVDQ--MRQH------FVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLT 292
Cdd:COG5808 214 LLQYNLLKRKTLLERVIQeiNTQKleligtFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQKYFDIIQEEIQRINQIV 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 293 TELLLLSELDNHQHLLFDdkikVDQLIKDIIR--HEQFAADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDV 370
Cdd:COG5808 294 SEFLVLGKPTAKKLELDD----LNELIEEILSiiDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKE 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 371 GGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFykVSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTI 450
Cdd:COG5808 370 GGKLTISIENDDEKAVIEVIDNGEGIPEDIIDEIFEPF--VTTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTI 447
|
...
gi 446399482 451 TLP 453
Cdd:COG5808 448 RLP 450
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
228-453 |
5.10e-20 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 91.01 E-value: 5.10e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 228 KMrESLGQVdqmrqhfVQNVSHEIKTPLT----HIHHLLSELQQTSDKTLRQQYINDIY-------TITtqlsglttell 296
Cdd:COG4191 138 KL-AALGEL-------AAGIAHEINNPLAailgNAELLRRRLEDEPDPEELREALERILegaeraaEIV----------- 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 297 llseldnhQHLLF------DDKIKVD--QLIKDIIR--HEQFAADEKSLIILADLESINFLGNQRLLHQALSNLLINAIk 366
Cdd:COG4191 199 --------RSLRAfsrrdeEEREPVDlnELIDEALEllRPRLKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAI- 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 367 ytD-----VGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFY---KVSKHdnsNGLGLAITKSIIELHHGTIQF 438
Cdd:COG4191 270 --DameegEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFttkPVGKG---TGLGLSISYGIVEKHGGRIEV 344
|
250
....*....|....*.
gi 446399482 439 TqSNEYV-TTFTITLP 453
Cdd:COG4191 345 E-SEPGGgTTFTITLP 359
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-453 |
5.65e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 84.75 E-value: 5.65e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 353 LHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYK--VSKHDNSNGLGLAITKSIIE 430
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRgdNSRNTEGAGLGLSIAKAIIE 80
|
90 100
....*....|....*....|...
gi 446399482 431 LHHGTIQFTQSNEYvTTFTITLP 453
Cdd:cd16923 81 LHGGSASAEYDDNH-DLFKVRLP 102
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
353-453 |
1.06e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 84.08 E-value: 1.06e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 353 LHQALSNLLINAIKYTDVGG-AIDIALQHSHNN---IIFTISNDGSPISPQAEARLFERFYKVskhDNSN-------GLG 421
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEvTLRVSLEEEEEDgvqLRFSVEDTGIGIPEEQQARLFEPFSQA---DSSTtrkyggtGLG 77
|
90 100 110
....*....|....*....|....*....|...
gi 446399482 422 LAITKSIIELHHGTIQFtQSNEYV-TTFTITLP 453
Cdd:cd16922 78 LAISKKLVELMGGDISV-ESEPGQgSTFTFTLP 109
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
190-443 |
1.25e-19 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 90.74 E-value: 1.25e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 190 RPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMRQHFVQNVSHEIKTPLTHIHhLLSELQQTS 269
Cdd:PRK09467 179 RPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIKQLEDDRTLLMAGVSHDLRTPLTRIR-LATEMMSEE 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 270 DKTLRQQYINDIY---TITTQlsglttellllseldnhqhllFDDKIKVDQ-----------LIKDII-----RHEQFAA 330
Cdd:PRK09467 258 DGYLAESINKDIEecnAIIEQ---------------------FIDYLRTGQempmemadlnaLLGEVIaaesgYEREIET 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 331 DEKSLIILADLESINflgnqrlLHQALSNLLINAIKYTdvGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYK 410
Cdd:PRK09467 317 ALQPGPIEVPMNPIA-------IKRALANLVVNAARYG--NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTR 387
|
250 260 270
....*....|....*....|....*....|....*
gi 446399482 411 VSKHDNS--NGLGLAITKSIIELHHGTIQFTQSNE 443
Cdd:PRK09467 388 GDSARGSsgTGLGLAIVKRIVDQHNGKVELGNSEE 422
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-438 |
9.89e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 81.30 E-value: 9.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 341 LESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQ-HSHNNIIftISNDGSPISPQAEARLFERFYKV-SKHDNSN 418
Cdd:cd16940 2 AADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSaDDGAVIR--VEDNGPGIDEEELEALFERFYRSdGQNYGGS 79
|
90 100
....*....|....*....|
gi 446399482 419 GLGLAITKSIIELHHGTIQF 438
Cdd:cd16940 80 GLGLSIVKRIVELHGGQIFL 99
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-453 |
1.31e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 78.27 E-value: 1.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 349 NQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDN----SNGLGLAI 424
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNrasgGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 446399482 425 TKSIIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
352-437 |
2.40e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 77.50 E-value: 2.40e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 352 LLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDN---SNGLGLAITKSI 428
Cdd:cd16945 4 LLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSgqkSTGLGLAFVQEV 83
|
....*....
gi 446399482 429 IELHHGTIQ 437
Cdd:cd16945 84 AQLHGGRIT 92
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
247-453 |
2.42e-17 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 84.01 E-value: 2.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 247 VSHEIKTPLTHIHHLLSELQQTSDKtlRQQY-------INDIYTITTQLSGLTTELLLLSELDNhqhllfddkikVDQLI 319
Cdd:COG5805 294 IAHEIRNPLTSIKGFLQLLQPGIED--KEEYfdimlseLDRIESIISEFLALAKPQAVNKEKEN-----------INELI 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 320 KDIIRHEQFAA--DEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPIS 397
Cdd:COG5805 361 QDVVTLLETEAilHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIP 440
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 446399482 398 PQAEARLFERFYkvSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:COG5805 441 EERLKKLGEPFF--TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
247-453 |
3.28e-17 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 82.91 E-value: 3.28e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 247 VSHEIKTPLTHIHHLLSELQQTSDKTLRQQY-------INDIYTITTQLSGLTTELLLlseldNHQhllfddKIKVDQLI 319
Cdd:COG5807 154 IAHEIRNPLTSIKGFLQLLQESREDSEREEYfniiiseIDRINTIITELLVLSKPKKF-----NFK------KLNLNDVL 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 320 KDIIRHEQFAADEKSLIILADLES----INflGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSP 395
Cdd:COG5807 223 EDVIALLSTEAILKNISIKYDLADdepvIN--GDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEGIG 300
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 446399482 396 ISPQAEARLFERFYkvSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:COG5807 301 IPEEVLEKIGEPFF--TTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLP 356
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
352-453 |
5.11e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 76.31 E-value: 5.11e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 352 LLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNSNGLGLAITKSIIEL 431
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRIIQK 82
|
90 100
....*....|....*....|..
gi 446399482 432 HHGTIQFTQSNEYVTTFTITLP 453
Cdd:cd16943 83 HGGTIRVASVPGGGTRFTIILP 104
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
228-453 |
1.69e-16 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 80.66 E-value: 1.69e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 228 KMRESLGQVDQMR--QHFVQNVSHEIKTPLTHIHH----LLSELQQTSDKTLRQQYINDIY---TITTQlsglttellll 298
Cdd:COG3852 121 RLERELRRAEKLAavGELAAGLAHEIRNPLTGIRGaaqlLERELPDDELREYTQLIIEEADrlnNLVDR----------- 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 299 seldnhqhLLFDDKIKVDQL----IKDIIRH-EQFAADE--KSLIILADLE-SI-NFLGNQRLLHQALSNLLINAIKYTD 369
Cdd:COG3852 190 --------LLSFSRPRPPERepvnLHEVLERvLELLRAEapKNIRIVRDYDpSLpEVLGDPDQLIQVLLNLVRNAAEAMP 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 370 VGGAI----------DIALQHSHNNIIFTISNDGSPISPQAEARLFERFykVSKHDNSNGLGLAITKSIIELHHGTIQFT 439
Cdd:COG3852 262 EGGTItirtrverqvTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPF--FTTKEKGTGLGLAIVQKIVEQHGGTIEVE 339
|
250
....*....|....
gi 446399482 440 QSNEYVTTFTITLP 453
Cdd:COG3852 340 SEPGKGTTFRIYLP 353
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-453 |
1.77e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 74.67 E-value: 1.77e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 353 LHQALSNLLINAIKYTDvgGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNSN----GLGLAITKSI 428
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDREsggtGLGLAIAERA 78
|
90 100
....*....|....*....|....*
gi 446399482 429 IELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
228-456 |
2.10e-16 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 81.55 E-value: 2.10e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 228 KMRESLGQVDQMRQ--HFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIY-------TITTQlsglttellll 298
Cdd:PRK11360 376 RLQRRVARQERLAAlgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLrevdrlnKVIDQ----------- 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 299 seldnhqhLLF--------DDKIKVDQLIKDIIRHEQFAA-DEKSLIILA---DLESINFLGNQrlLHQALSNLLINAIK 366
Cdd:PRK11360 445 --------LLEfsrpresqWQPVSLNALVEEVLQLFQTAGvQARVDFETEldnELPPIWADPEL--LKQVLLNILINAVQ 514
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 367 YTDVGGAIDIAL-QHSHNNIIFTISNDGSPISPQAEARLFERFYkvSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYV 445
Cdd:PRK11360 515 AISARGKIRIRTwQYSDGQVAVSIEDNGCGIDPELLKKIFDPFF--TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVG 592
|
250
....*....|.
gi 446399482 446 TTFTITLPNNS 456
Cdd:PRK11360 593 TTFTLYLPINP 603
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
187-453 |
1.09e-15 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 79.56 E-value: 1.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 187 SIIRPVKKLKLATERLIDGDFETPIKQT----RKDEIGTLQYHF-------NKMRESLGQVDQMR---------QH---- 242
Cdd:PRK11466 355 SVTRPLAEQTQALQRLLDGDIDSPFPETagvrELDTIGRLMDAFrsnvhalNRHREQLAAQVKARtaelqelviEHrqar 434
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 243 ------------FVQNVSHEIKTPLthiHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELL-----LLSELDNHQ 305
Cdd:PRK11466 435 aeaekasqaksaFLAAMSHEIRTPL---YGILGTAQLLADNPALNAQRDDLRAITDSGESLLTILNdildySAIEAGGKN 511
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 306 HLLFDDKIKVDQLIKDIIRHEQFAADEKSLIILADLESI---NFLGNQRLLHQALSNLLINAIKYTDvGGAIDIALQHSH 382
Cdd:PRK11466 512 VSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDlptALMGDPRRIRQVITNLLSNALRFTD-EGSIVLRSRTDG 590
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446399482 383 NNIIFTISNDGSPISPQAEARLFERFYKVSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:PRK11466 591 EQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
312-453 |
2.96e-15 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 77.71 E-value: 2.96e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 312 KIKVDQLIKDIIRHEQFAADEKSLIILADLES--INFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQ-HSHNNIIFT 388
Cdd:COG5809 337 PKDLNTLIEEVIPLLQPQALLKNVQIELELEDdiPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKaEDDDKVVIS 416
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446399482 389 ISNDGSPISPQAEARLFERFYkvSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:COG5809 417 VTDEGCGIPEERLKKLGEPFY--TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
175-453 |
3.17e-15 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 77.34 E-value: 3.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 175 FISISLVIAsTYSIIRP----VKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMRQHFVQNVSHE 250
Cdd:PRK10604 144 LIGLSLAFP-VFLWMRPhwqdMLKLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNINALIASKKQLIDGIAHE 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 251 IKTPLTHIHHLLSELQQTSDKtlRQQYIN-DIytitTQLSGLTTELLLLSELDNHQHLLFDDKIKVDQLIKDIIRHEQFA 329
Cdd:PRK10604 223 LRTPLVRLRYRLEMSDNLSAA--ESQALNrDI----GQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAV 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 330 ADEKSlIILADLESINFLG-NQRLLHQALSNLLINAIKYTdvGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERF 408
Cdd:PRK10604 297 TPEKT-VRLDTPHQGDYGAlDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPF 373
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 446399482 409 YKVSK-HDNSNG---LGLAITKSIIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:PRK10604 374 VRLDPsRDRATGgcgLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
215-453 |
5.51e-15 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 76.43 E-value: 5.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 215 RKDEIGTLQYHFNKMREslgQVDQMRqhfVQNvsHEIKTPLTHIHHLLsELQQTSDktlRQQYINDIytittqlsgltte 294
Cdd:COG3290 172 DRTELERLEEELEGVKE---LAEALR---AQR--HDFRNHLHTISGLL-QLGEYDE---ALEYIDEI------------- 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 295 llllseLDNHQHLLFDDKIKVDQLIKDII----------RHEQFAADEKSLIILADLESInflgnqrLLHQALSNLLINA 364
Cdd:COG3290 227 ------SEELQELIDSLLSRIGNPVLAALllgkaarareRGIDLTIDIDSDLPDLPLSDT-------DLVTILGNLLDNA 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 365 I----KYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFER-FYkvSKHDNSNGLGLAITKSIIELHHGTIQFT 439
Cdd:COG3290 294 IeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERgFS--TKLGEGRGLGLALVKQIVEKYGGTIEVE 371
|
250
....*....|....
gi 446399482 440 QSNEYVTTFTITLP 453
Cdd:COG3290 372 SEEGEGTVFTVRLP 385
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
189-443 |
2.30e-14 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 74.69 E-value: 2.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 189 IRPVKKLKlATERLIDGDFETPIKQTR-KDEIGTLQYHFNKMRESLGQVDQMRQHFVQNVSHEIKTPLTHIHhLLSELQQ 267
Cdd:PRK10337 186 LAPLKKLA-LALRMRDPDSETPLNATGvPSEVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSPLAALK-VQTEVAQ 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 268 TS--DKTLRQQYINDIYTITTQLSGLTTELLLLSELDNHQHLLFDDKIKVDQLIK----DIIRHEQFAADEKSLIILADl 341
Cdd:PRK10337 264 LSddDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQsavmDIYHTAQQAGIDVRLTLNAH- 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 342 eSINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALqhshNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNS-NGL 420
Cdd:PRK10337 343 -PVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTL----NARNFTVRDNGPGVTPEALARIGERFYRPPGQEATgSGL 417
|
250 260
....*....|....*....|...
gi 446399482 421 GLAITKSIIELHHGTIQFTQSNE 443
Cdd:PRK10337 418 GLSIVRRIAKLHGMNVSFGNAPE 440
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
207-457 |
6.17e-14 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 74.29 E-value: 6.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 207 FETPIKQTRKDEIG-----------TLQYHF----NKMRESLGQVDQMRQHFVQ----------NVSHEIKTPLTHIHHL 261
Cdd:PRK15347 340 LEPRLPENRLDELGsiakaynqlldTLNEQYdtleNKVAERTQALAEAKQRAEQankrksehltTISHEIRTPLNGVLGA 419
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 262 LsELQQTSDKTLRQQYINDiytiTTQLSGLTTELLLLSELD-----NHQHLLFDDKIKVDQLIKDIIRHEQFAADEKSL- 335
Cdd:PRK15347 420 L-ELLQNTPLTAEQMDLAD----TARQCTLSLLAIINNLLDfsrieSGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLt 494
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 336 ---IILADLESINFLGNQRLlHQALSNLLINAIKYTDVGGaIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVS 412
Cdd:PRK15347 495 lrtFVGAHVPLYLHLDSLRL-RQILVNLLGNAVKFTETGG-IRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQAD 572
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 446399482 413 KHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLPNNSH 457
Cdd:PRK15347 573 THSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLNEY 617
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-453 |
7.94e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 67.61 E-value: 7.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 353 LHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNSN----GLGLAITKSI 428
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNtggtGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 446399482 429 IELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
359-453 |
1.21e-13 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 67.13 E-value: 1.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 359 NLLINAIKYTDVGGAIDIALQHSH-NNIIFTISNDGSPISPQAEARLFERFYKV----SKHDNSNGLGLAITKSIIELHH 433
Cdd:cd16925 11 NLLSNAFKFTPDGGRIRCILEKFRlNRFLLTVSDSGPGIPPNLREEIFERFRQGdgssTRAHGGTGLGLSIVKEFVELHG 90
|
90 100
....*....|....*....|
gi 446399482 434 GTIQFTQSNEYVTTFTITLP 453
Cdd:cd16925 91 GTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
347-452 |
1.24e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 67.54 E-value: 1.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 347 LGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNS----NGLGL 422
Cdd:cd16947 15 NANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSakqgNGLGL 94
|
90 100 110
....*....|....*....|....*....|.
gi 446399482 423 AITKSIIELHHGTIqFTQSNEYV-TTFTITL 452
Cdd:cd16947 95 TITKRLAESMGGSI-YVNSKPYEkTVFTVTL 124
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-453 |
3.85e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 65.50 E-value: 3.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 353 LHQALSNLLINAIKYTDVGGAI--DIALQHSHNN---IIFTISNDGSPISPQAEARLFERFYkVSKHDNSnGLGLAITKS 427
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCErrELTIRTSPADdraVTISVKDTGPGIAEEVAGQLFDPFY-TTKSEGL-GMGLSICRS 78
|
90 100
....*....|....*....|....*.
gi 446399482 428 IIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:cd16920 79 IIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-453 |
1.05e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 64.27 E-value: 1.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 353 LHQALSNLLINAIKYT--DVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNS--NGLGLAITKSI 428
Cdd:cd16921 1 LGQVLTNLLGNAIKFRrpRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYegTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 446399482 429 IELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:cd16921 81 IERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
189-233 |
2.57e-12 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 60.92 E-value: 2.57e-12
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 446399482 189 IRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESL 233
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
225-453 |
4.36e-12 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 67.58 E-value: 4.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 225 HFNKMRESLGQVDQMR--QHFVQNVSHEIKTPLTHIH---HLLSELQQTSDKtlRQQY--------------INDIYTIT 285
Cdd:COG5806 184 ENILLRKELQRAEKLEvvSELAASIAHEVRNPLTVVRgfiQLLQEPELSDEK--RKQYirialeeldraeaiITDYLTFA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 286 tqlsglttelllLSELDNHQhllfddKIKVDQLIKDIIRHEQFAADEKSLIILADLE-SINFLGNQRLLHQALSNLLINA 364
Cdd:COG5806 262 ------------KPQPEKLE------KIDVSEELEHVIDVLSPYANMNNVEIQTELEpGLYIEGDRQKLQQCLINIIKNG 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 365 IKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYkvSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEY 444
Cdd:COG5806 324 IEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYF--STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGK 401
|
....*....
gi 446399482 445 VTTFTITLP 453
Cdd:COG5806 402 GTTFTITLP 410
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
352-453 |
6.35e-12 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 67.75 E-value: 6.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 352 LLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDN--SNGLGLAITKSII 429
Cdd:PRK10490 778 LFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAipGVGLGLAICRAIV 857
|
90 100
....*....|....*....|....
gi 446399482 430 ELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:PRK10490 858 EVHGGTIWAENRPEGGACFRVTLP 881
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
147-453 |
7.54e-12 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 66.97 E-value: 7.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 147 IAVFMRPDIGETFSEFRTFLAVLLMLLLFISISLVIASTYSIIRPVKKLKLATERLIDGDFeTPIKQTRKDEIGTLQYHF 226
Cdd:COG2972 140 VSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSF 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 227 NKMRESLGQVD--------------------QMRQHFVQNVsheiktpLTHIHHLLselqQTSDKTLRQQYINDI----- 281
Cdd:COG2972 219 NEMVERIKELIeevyelelekkeaelkalqaQINPHFLFNT-------LNSIRWLA----ELEDPEEAEEMLEALskllr 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 282 YTIttqlsglttellllseLDNHQHLLFDDKIKvdqLIKDIIRHEQFAADEK-SLIILADLEsinfLGNQRLLHQALSNL 360
Cdd:COG2972 288 YSL----------------SKGDELVTLEEELE---LIKSYLEIQKLRFGDRlEVEIEIDEE----LLDLLIPKLILQPL 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 361 LINAIKY----TDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFykvSKHDNSNGLGLAITKSIIELHHG-- 434
Cdd:COG2972 345 VENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL---SSKGEGRGIGLRNVRERLKLYYGee 421
|
330 340
....*....|....*....|
gi 446399482 435 -TIQFTQSNEYVTTFTITLP 453
Cdd:COG2972 422 yGLEIESEPGEGTTVTIRIP 441
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-453 |
1.33e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 61.15 E-value: 1.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 356 ALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFY--KVSKHDN-SNGLGLAITKSIIE-L 431
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFtgENGRNFQeSTGMGLYLVKKLCDkL 88
|
90 100
....*....|....*....|..
gi 446399482 432 HHGTIQFTQSNEYvTTFTITLP 453
Cdd:cd16948 89 GHKIDVESEVGEG-TTFTITFP 109
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
353-455 |
2.18e-11 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 65.58 E-value: 2.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 353 LHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYkVSKHDNSnGLGLAITKSIIELH 432
Cdd:PRK10364 349 LTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYF-TTKAEGT-GLGLAVVHNIVEQH 426
|
90 100
....*....|....*....|...
gi 446399482 433 HGTIQFTQSNEYVTTFTITLPNN 455
Cdd:PRK10364 427 GGTIQVASQEGKGATFTLWLPVN 449
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-453 |
2.98e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 60.14 E-value: 2.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 353 LHQALSNLLINAIKYTDvgGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKV-SKHDNSN---GLGLAITKSI 428
Cdd:cd16939 1 MARALDNLLRNALRYAH--RTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLdPSRDRATggfGLGLAIVHRV 78
|
90 100
....*....|....*....|....*
gi 446399482 429 IELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLTWP 103
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-436 |
8.15e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 59.01 E-value: 8.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 349 NQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNSN---GLGLAIT 425
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGghyGMGLYIA 80
|
90
....*....|.
gi 446399482 426 KSIIELHHGTI 436
Cdd:cd16975 81 KNLVEKHGGSL 91
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
175-403 |
9.70e-11 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 63.98 E-value: 9.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 175 FISISLVIASTYSIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVDQMRQHFVQnVSHEIKTP 254
Cdd:COG2770 223 LLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEE-LAEAELAR 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 255 LTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSELDNHQHLLFDDKIKVDQLIKDIIRHEQFAADEKS 334
Cdd:COG2770 302 LLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEA 381
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446399482 335 LIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEAR 403
Cdd:COG2770 382 LALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAA 450
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
240-453 |
1.28e-10 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 63.99 E-value: 1.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 240 RQHFVQNVSHEIKTPLTHIHHLLSELQQTS-DKTLRQQYINDIYTITTQLSGLTTELLLLSELDNHQHLLFDDKIKVDQL 318
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSGlSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTL 791
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 319 IKDIIRHEQFAADEKSLII-----LADLESINFlgNQRLLHQALSNLLINAIKYTDVGGA-IDIALQH---SHNNIIFTI 389
Cdd:PRK09959 792 VQNTCHSFGAIAASKSIALscsstFPDHYLVKI--DPQAFKQVLSNLLSNALKFTTEGAVkITTSLGHiddNHAVIKMTI 869
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446399482 390 SNDGSPISPQAEARLFERFYKVS--KHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:PRK09959 870 MDSGSGLSQEEQQQLFKRYSQTSagRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
228-453 |
1.77e-10 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 63.45 E-value: 1.77e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 228 KMRESLG-------QVDQMRQHFVQNVSHEIKTPLTHIHHLLsELQQTsdKTLRQ-----------------QYINDIyt 283
Cdd:PRK10841 428 KMEESLQemaqaaeQASQSKSMFLATVSHELRTPLYGIIGNL-DLLQT--KELPKgvdrlvtamnnssslllKIISDI-- 502
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 284 ittqlsglttellllseldnhqhLLFDdKIKVDQL--------IKDIIRHeqFAADEKSLIILADLESINF--------- 346
Cdd:PRK10841 503 -----------------------LDFS-KIESEQLkieprefsPREVINH--ITANYLPLVVKKRLGLYCFiepdvpval 556
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 347 LGNQRLLHQALSNLLINAIKYTDVGGAIdIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVS----KHDNSNGLGL 422
Cdd:PRK10841 557 NGDPMRLQQVISNLLSNAIKFTDTGCIV-LHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGtgvqRNFQGTGLGL 635
|
250 260 270
....*....|....*....|....*....|..
gi 446399482 423 AITKSIIELHHGTIQFtQSNEYV-TTFTITLP 453
Cdd:PRK10841 636 AICEKLINMMDGDISV-DSEPGMgSQFTIRIP 666
|
|
| HAMP |
pfam00672 |
HAMP domain; |
187-233 |
4.24e-10 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 54.94 E-value: 4.24e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 446399482 187 SIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESL 233
Cdd:pfam00672 5 RILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERL 51
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
188-442 |
5.73e-10 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 60.75 E-value: 5.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 188 IIRPVKKLklaTERLID--GDFETPIKQTRK-DEI----GTLQYHFNKMRESLgqvDQMRQhFVQNVSHEIKTPLTHIH- 259
Cdd:PRK10755 85 ITRPLAEL---QKELEArtADNLTPIAIHSStLEIeavtSALNQLVSRLTSTL---DQERL-FTADVAHELRTPLAGIRl 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 260 HL-LSELQQTSDKTLRQQYInDIYTITTQLSGLTTELLLLSELDNHQHLlfddkikvdQLIKDIIR------HEQFAADE 332
Cdd:PRK10755 158 HLeLLEKQHHIDVAPLIARL-DQMMHTVEQLLQLARAGQSFSSGHYQTV---------KLLEDVILpsqdelSEMLEQRQ 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 333 KSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVS 412
Cdd:PRK10755 228 QTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD 307
|
250 260 270
....*....|....*....|....*....|
gi 446399482 413 KHDNSNGLGLAITKSIIELHHGtiQFTQSN 442
Cdd:PRK10755 308 SRYGGIGLGLSIVSRITQLHHG--QFFLQN 335
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
332-453 |
6.31e-10 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 60.74 E-value: 6.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 332 EKSLIILADLES--INFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNII-FTISNDGSPIsPQAE-ARLFER 407
Cdd:PRK09303 250 AKSLEIQTDIPSdlPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSMLHRTTQKVqVSICDTGPGI-PEEEqERIFED 328
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 446399482 408 FYKVSKHDNSN--GLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:PRK09303 329 RVRLPRDEGTEgyGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-453 |
1.31e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 55.66 E-value: 1.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 353 LHQALSNLLINAIKYT-DVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFY----KVSKHDNSNGLGLAITKS 427
Cdd:cd16953 1 LGQVLRNLIGNAISFSpPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYterpANEAFGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 446399482 428 IIELHHGTI---QFTQSNEYV-TTFTITLP 453
Cdd:cd16953 81 IIEAHGGISvaeNHNQPGQVIgARFTVQLP 110
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-437 |
2.00e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 54.76 E-value: 2.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 353 LHQALSNLLINAIKYTdvGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNS--NGLGLAITKSIIE 430
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTsgTGLGLAIVQRISD 78
|
....*..
gi 446399482 431 LHHGTIQ 437
Cdd:cd16950 79 AHGGSLT 85
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
332-441 |
2.59e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 55.33 E-value: 2.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 332 EKSLIILADL-ESINFLGNQRLLHQALSNLLINAIKYTDvgGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYK 410
Cdd:cd16954 16 RKGVSISLDIsPELRFPGERNDLMELLGNLLDNACKWCL--EFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQR 93
|
90 100 110
....*....|....*....|....*....|.
gi 446399482 411 VSKHDNSNGLGLAITKSIIELHHGTIQFTQS 441
Cdd:cd16954 94 LDEQRPGQGLGLAIAKEIVEQYGGELSLSDS 124
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
187-233 |
2.73e-09 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 52.64 E-value: 2.73e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 446399482 187 SIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESL 233
Cdd:smart00304 2 RLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRL 48
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
243-453 |
3.21e-09 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 59.18 E-value: 3.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 243 FVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYT--ITtqlsglttellllseLDNhqhlLFDDKIKVD---- 316
Cdd:PRK11091 286 FISTISHELRTPLNGIVGLSRILLDTELTAEQRKYLKTIHVsaIT---------------LGN----IFNDIIDMDkmer 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 317 ---QLIKDIIRHEQFAADEKSLI-ILADLESINFLGNQRL------------LHQALSNLLINAIKYTDVGGAIDIALQH 380
Cdd:PRK11091 347 rklQLDNQPIDFTDFLADLENLSgLQAEQKGLRFDLEPLLplphkvitdgtrLRQILWNLISNAVKFTQQGGVTVRVRYE 426
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446399482 381 SHNNIIFTISNDGSPIsPQAE-ARLFERFYKV-SKHDN----SNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:PRK11091 427 EGDMLTFEVEDSGIGI-PEDElDKIFAMYYQVkDSHGGkpatGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| ArsS_fam_HK |
NF038389 |
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ... |
11-433 |
6.82e-09 |
|
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.
Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 57.55 E-value: 6.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 11 IYSITVILFSALISFVLT----------NVYYHYNLKASNdakIMKTLKeaRQYEQSAKPTHIQQYFKHLGQMNYQIMTV 80
Cdd:NF038389 4 FFKITILFAIALVSVSALflillkyqkeNYNEELNKKYSL---IANTLL--QLYQKNINEEELEKYLKNFGFMPITDKKL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 81 DQKGHKTFYGEPFREDTLSQNAINnvLNNKDYHGIKDKPFALFvtgFFDNvtdntvgINFKTKDGSIAVFMrpdigetfs 160
Cdd:NF038389 79 EKEILEIGKNKFILKENGSFRILK--YNDKIYLLIKNDGFSLL---LEDN-------EKKSYRYYYIIVFF--------- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 161 efrtflavllmlllFISISLVIASTYSIIR---PVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLGQVD 237
Cdd:NF038389 138 --------------IFLILLLLILYISVLKslkPLKKLKKQIKKFANGDFDFIKSESNGDEIGEVANEFDKAVKKIKALN 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 238 QMRQHFVQNVSHEIKTPLTHiHHLLSELQQtsDKTLRQQYINdIYtittqlsglttellllseldNHQHLLFDDKIKVDQ 317
Cdd:NF038389 204 ESRQLFLRNIMHELKTPITK-GRIVAEMLE--DEKQKERLIS-IF--------------------ERLESLINEFAKIEQ 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 318 L-------------IKDIIRH--EQFAADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIAlqhSH 382
Cdd:NF038389 260 LtsknyklnkkeyrLSDIIDEaiDMLMIDDSSVIIKVSLEDFKLNVDFELFSLAIKNLIDNAIKYSPDKKVTIEI---KG 336
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 446399482 383 NNIIFtiSNDGSPISPQAEaRLFERFYK-VSKHDNSNGLGLAITKSIIELHH 433
Cdd:NF038389 337 DKIEF--KNKGEPLEEPLE-YYFEPFFKgNEKSKSGFGLGLYIVKNILKAHG 385
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
176-451 |
9.48e-09 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 57.20 E-value: 9.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 176 ISISLVIASTYSIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESLG-------QVDQMRQHFVQNVS 248
Cdd:COG3850 130 LALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQelyaeleEEEELEAELELLAL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 249 HEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIYTITTQLSGLTTELLLLSELDNHQHLLFDDKIKVDQLIKDIIRHEQF 328
Cdd:COG3850 210 LDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALL 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 329 AADEKSLIILADLESINFLGNQRLLHQALSNLLINAIKYTDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERF 408
Cdd:COG3850 290 LELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAA 369
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 446399482 409 YKVSKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTIT 451
Cdd:COG3850 370 GLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVAG 412
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
176-436 |
1.53e-08 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 57.00 E-value: 1.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 176 ISISLVIASTYSIIRP--VKKLKL---ATERLIDGDFETPIKQTRKDEIG----TLQYHFNKMRESLGQVDQM--RQHFV 244
Cdd:COG4192 334 LSLLLAVLINYFYVRRrlVKRLNAlsdAMAAIAAGDLDVPIPVDGNDEIGriarLLRVFRDQAIEKTQELETEieERKRI 413
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 245 QN------------------------VSHEIKTPL----THIHHLLSELQQTSDKTLRqQYINDIYTITTQLSGLTTELL 296
Cdd:COG4192 414 EKnlrqtqdeliqaakmavvgqtmtsLAHELNQPLnamsMYLFSAKKALEQENYAQLP-TSLDKIEGLIERMDKIIKSLR 492
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 297 LLSELDNHQHLLFDdkikVDQLIKDI-----IRHEQfaadEKSLIILADleSINFLGNQRLLHQALSNLLINAIKYTDVG 371
Cdd:COG4192 493 QFSRKSDTPLQPVD----LRQVIEQAwelveSRAKP----QQITLHIPD--DLMVQGDQVLLEQVLVNLLVNALDAVATQ 562
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446399482 372 GAIDIALQHSHNNIIFTISNDGS--PISPqaeaRLFERFYkvSKHDNSNGLGLAITKSIIELHHGTI 436
Cdd:COG4192 563 PQISVDLLSNAENLRVAISDNGNgwPLVD----KLFTPFT--TTKEVGLGLGLSICRSIMQQFGGDL 623
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
353-453 |
2.17e-08 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 56.78 E-value: 2.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 353 LHQALSNLLINAIKYTDvGGAIDIALQH---SHNNII--FTISNDGSPISPQAEARLFERFykvSKHDNS-------NGL 420
Cdd:PRK11107 409 LQQIITNLVGNAIKFTE-SGNIDILVELralSNTKVQleVQIRDTGIGISERQQSQLFQAF---RQADASisrrhggTGL 484
|
90 100 110
....*....|....*....|....*....|...
gi 446399482 421 GLAITKSIIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:PRK11107 485 GLVITQKLVNEMGGDISFHSQPNRGSTFWFHLP 517
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-453 |
2.71e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 51.52 E-value: 2.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 357 LSNLLINAIKYT----DVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKvSKHDNSNGLGLAITKSIIELH 432
Cdd:cd16915 5 VGNLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-TKGQGERGIGLALVRQSVERL 83
|
90 100
....*....|....*....|.
gi 446399482 433 HGTIQFTQSNEYVTTFTITLP 453
Cdd:cd16915 84 GGSITVESEPGGGTTFSIRIP 104
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
154-276 |
5.78e-08 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 55.03 E-value: 5.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 154 DIGETFSEFRTFLAVLLMLLLFISISLVIASTYSIIRPVKKLKLATERLIDGDFETPIKQTRKDEIGTLQYHFNKMRESL 233
Cdd:COG0840 172 LALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENL 251
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 446399482 234 GQVdqMRQhfVQNVSHEIKtplTHIHHLLSELQQTSDKTLRQQ 276
Cdd:COG0840 252 REL--VGQ--VRESAEQVA---SASEELAASAEELAAGAEEQA 287
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-453 |
5.91e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 50.86 E-value: 5.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 353 LHQALSNLLINAIK-YTDVGGAIDIALQHSHNNII----------FTISNDGSPISPQAEARLFERFykVSKHDNSNGLG 421
Cdd:cd16918 1 LIQVFLNLVRNAAQaLAGSGGEIILRTRTQRQVTLghprhrlalrVSVIDNGPGIPPDLQDTIFYPM--VSGRENGTGLG 78
|
90 100 110
....*....|....*....|....*....|..
gi 446399482 422 LAITKSIIELHHGTIQFTqSNEYVTTFTITLP 453
Cdd:cd16918 79 LAIAQNIVSQHGGVIECD-SQPGHTVFSVSLP 109
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
360-453 |
3.39e-07 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 52.60 E-value: 3.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 360 LLINAIKY---TDVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARlferfykvskhdNSNGLGLAITKSIIELHHGTI 436
Cdd:COG3920 407 LVTNALKHaflSGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDVDPP------------ARKGLGLRLIRALVRQLGGTL 474
|
90
....*....|....*..
gi 446399482 437 QFTQSNEyvTTFTITLP 453
Cdd:COG3920 475 ELDRPEG--TRVRITFP 489
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-452 |
4.19e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 48.22 E-value: 4.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 353 LHQALSNLLINAikYTDVGG----AIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNSNGLGLAITKSI 428
Cdd:cd16976 1 IQQVLMNLLQNA--LDAMGKvenpRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGI 78
|
90 100
....*....|....*....|....
gi 446399482 429 IELHHGTIQFTQSNEYVTTFTITL 452
Cdd:cd16976 79 VEEHGGRLSVANEEGAGARFTFDL 102
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
357-453 |
6.12e-07 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 51.84 E-value: 6.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 357 LSNLLINAIKYTD--VGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKvSKHDNsNGLGLAITKSIIELHHG 434
Cdd:PRK11086 438 LGNLIENALEAVGgeEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYS-TKGSN-RGVGLYLVKQSVENLGG 515
|
90
....*....|....*....
gi 446399482 435 TIQFTQSNEYVTTFTITLP 453
Cdd:PRK11086 516 SIAVESEPGVGTQFFVQIP 534
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
237-287 |
1.86e-06 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 45.28 E-value: 1.86e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 446399482 237 DQMRQHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQ-YINDIYTITTQ 287
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQReYLERIREEAER 52
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
351-453 |
2.77e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 45.99 E-value: 2.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 351 RLLHQALSNLLINAI-----KYTDVG-GAIDIAlQHSHNNIIFTISNDGSPISPQAEARLFERFykVSKHDNSNGLGLAI 424
Cdd:cd16944 3 TQISQVLTNILKNAAeaiegRPSDVGeVRIRVE-ADQDGRIVLIVCDNGKGFPREMRHRATEPY--VTTRPKGTGLGLAI 79
|
90 100
....*....|....*....|....*....
gi 446399482 425 TKSIIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:cd16944 80 VKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
353-453 |
4.59e-06 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 48.54 E-value: 4.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 353 LHQALSNLLINAIK-YTDVGGAIDIALQHSHNNII----------FTISNDGSPISPQAEARLFerFYKVSKHDNSNGLG 421
Cdd:PRK11073 238 IEQVLLNIVRNALQaLGPEGGTITLRTRTAFQLTLhgeryrlaarIDIEDNGPGIPPHLQDTLF--YPMVSGREGGTGLG 315
|
90 100 110
....*....|....*....|....*....|..
gi 446399482 422 LAITKSIIELHHGTIQFTqSNEYVTTFTITLP 453
Cdd:PRK11073 316 LSIARNLIDQHSGKIEFT-SWPGHTEFSVYLP 346
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
344-441 |
2.09e-05 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 46.93 E-value: 2.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 344 INFLGNQRLLHQALSNLLINAIKYtdVGGAIDIALQHSHNNIIFTISNDGSPISPQAEARLFERFYKVSKHDNSNGLGLA 423
Cdd:PRK10815 370 ITFVGEKNDFMEVMGNVLDNACKY--CLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRPGQGLGLS 447
|
90
....*....|....*...
gi 446399482 424 ITKSIIELHHGTIQFTQS 441
Cdd:PRK10815 448 VAREITEQYEGKISAGDS 465
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
239-282 |
3.56e-05 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 41.43 E-value: 3.56e-05
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 446399482 239 MRQHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIY 282
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETIL 44
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
347-453 |
4.96e-05 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 45.82 E-value: 4.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 347 LGNQRLLHQALSNLLINAIKYTDVGGAIDIALQH---------SHNNI------IFTISNDGSPISPQAEARLFERFYkv 411
Cdd:PRK13837 555 EGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRaklrapkvlSHGVLppgryvLLRVSDTGAGIDEAVLPHIFEPFF-- 632
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 446399482 412 SKHDNSNGLGLAITKSIIELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:PRK13837 633 TTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
351-453 |
6.60e-05 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 44.22 E-value: 6.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 351 RLLHQALSNllinAIKYtdvGGA--IDIALQHSHNNIIFTISNDGSPISPQAEARlferfykvskhdnsNGLGLAITKSI 428
Cdd:COG4585 165 RIVQEALTN----ALKH---AGAtrVTVTLEVDDGELTLTVRDDGVGFDPEAAPG--------------GGLGLRGMRER 223
|
90 100
....*....|....*....|....*
gi 446399482 429 IELHHGTIQFTQSNEYVTTFTITLP 453
Cdd:COG4585 224 AEALGGTLTIGSAPGGGTRVRATLP 248
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
239-282 |
2.37e-04 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 39.09 E-value: 2.37e-04
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 446399482 239 MRQHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDIY 282
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETIL 44
|
|
| HATPase_Phy-like |
cd16932 |
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ... |
348-452 |
2.23e-03 |
|
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.
Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 37.64 E-value: 2.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 348 GNQRLLHQALSNLLINAIKYTDV-GGAIDIALQHSHNNII---------FTISNDGSPISPQAEARLFERFYKVSKhdns 417
Cdd:cd16932 2 GDQIRLQQVLADFLLNAVRFTPSpGGWVEIKVSPTKKQIGdgvhvihleFRITHPGQGLPEELVQEMFEENQWTTQ---- 77
|
90 100 110
....*....|....*....|....*....|....*
gi 446399482 418 NGLGLAITKSIIELHHGTIQFTQSNEyVTTFTITL 452
Cdd:cd16932 78 EGLGLSISRKLVKLMNGDVRYLREAG-RSYFLITL 111
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-446 |
2.84e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 37.94 E-value: 2.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446399482 357 LSNLLINAI---KYTDVGGA-IDIALQHSHNNIIFTISNdgsPISPQAEaRLFERFYKvSKHDNSNGLGLAITKSIIELH 432
Cdd:cd16935 41 FGNLLDNAIeacAKIDKENRfIHLKIRQKKGFLIISIEN---SYEGELK-KKNGLFLS-TKKDKNHGIGLKSIREIVKKY 115
|
90
....*....|....
gi 446399482 433 HGTIQFTQSNEYVT 446
Cdd:cd16935 116 NGNLSIEYENGIFT 129
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
238-281 |
9.31e-03 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 38.37 E-value: 9.31e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 446399482 238 QMRQHFVQNVSHEIKTPLTHIHHLLSELQQTSDKTLRQQYINDI 281
Cdd:PRK10618 448 QARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPELDQL 491
|
|
| |
