|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09257 |
PRK09257 |
aromatic amino acid transaminase; |
1-397 |
0e+00 |
|
aromatic amino acid transaminase;
Pssm-ID: 181731 Cd Length: 396 Bit Score: 757.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 1 MFQKVDAYAGDPILSLMERFKDDSRHDKVNLSIGLYYNEDGIIPQLKTVAEAEARLNAQPhGASLYLPMEGLNTYRHTIA 80
Cdd:PRK09257 1 MFEHLEAAPADPILGLMEAFRADPRPDKVNLGVGVYKDEQGRTPVLRAVKKAEARLLETE-TTKNYLPIEGLAAYRQAVQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 81 PLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRF 160
Cdd:PRK09257 80 ELLFGADSPALAAGRVATVQTPGGTGALRVGADFLKRAFPDAKVWVSDPTWPNHRAIFEAAGLEVKTYPYYDAATKGLDF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 161 NDLLATLNTLPARSIVLLHPCCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDEDAYAIRAIASAGLPAL 240
Cdd:PRK09257 160 DAMLADLSQAPAGDVVLLHGCCHNPTGADLTPEQWDELAELLKERGLIPFLDIAYQGFGDGLEEDAYGLRAFAAAGLELL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 241 VSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLGDEALKASWLAEVDAMRTRII 320
Cdd:PRK09257 240 VASSFSKNFGLYGERVGALSVVAEDAEEADRVLSQLKATIRTNYSNPPAHGAAIVATILNDPELRAEWEAELEEMRERIK 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446409062 321 SMRQTLVKELKAEMPDRNFDYLLQQRGMFSYTGLSEEQVERLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM 397
Cdd:PRK09257 320 AMRQLLVEALKAKGPSRDFDFIARQRGMFSYSGLTPEQVDRLREEFGVYAVGSGRINVAGLNESNIDYVAEAIAAVL 396
|
|
| TyrB |
COG1448 |
Aspartate/aromatic aminotransferase [Amino acid transport and metabolism]; Aspartate/aromatic ... |
1-397 |
0e+00 |
|
Aspartate/aromatic aminotransferase [Amino acid transport and metabolism]; Aspartate/aromatic aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 441057 Cd Length: 396 Bit Score: 750.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 1 MFQKVDAYAGDPILSLMERFKDDSRHDKVNLSIGLYYNEDGIIPQLKTVAEAEARLNAQpHGASLYLPMEGLNTYRHTIA 80
Cdd:COG1448 1 MFEHLEAAPGDPILGLMEAFRADPRPNKVNLGVGVYKDEQGRTPVLRAVKAAEQRLLET-ETTKSYLPIEGDAAFNDAVQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 81 PLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRF 160
Cdd:COG1448 80 KLLFGADSPAVAAGRVATVQTPGGTGALRVGADFLKRAFPDATVWVSDPTWPNHRAIFEAAGLEVKTYPYYDAETGGVDF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 161 NDLLATLNTLPARSIVLLHPCCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDEDAYAIRAIASAGLPAL 240
Cdd:COG1448 160 DGMLADLKQLPAGDVVLLHGCCHNPTGADLTPEQWQEVAELLKERGLIPFLDIAYQGFGDGLEEDAAGLRLFAEAGPEFL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 241 VSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLGDEALKASWLAEVDAMRTRII 320
Cdd:COG1448 240 VASSFSKNFGLYRERVGALSVVAADAEEADRVLSQLKALIRTNYSNPPDHGAAIVATILNDPELRALWEAELAEMRERIK 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446409062 321 SMRQTLVKELKAEMPDRNFDYLLQQRGMFSYTGLSEEQVERLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM 397
Cdd:COG1448 320 AMRQQLVDALRAKGPSRDFSFIARQRGMFSYLGLSPEQVDRLREEFGIYMVGSGRINVAGLNESNIDYVAEAIAAVL 396
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
27-393 |
1.94e-88 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 271.49 E-value: 1.94e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 27 DKVNLSIGLYYNEdgiipQLKTVAEAEARLNAQpHGASLYLPMEGLNTYRHTIAPLLFgaDHPVLQQQRVATIQTLGGSG 106
Cdd:pfam00155 2 DKINLGSNEYLGD-----TLPAVAKAEKDALAG-GTRNLYGPTDGHPELREALAKFLG--RSPVLKLDREAAVVFGSGAG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 107 ALKVGADFLKrYFPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRFNDLLATLNTLParsIVLLHPCCHNPT 186
Cdd:pfam00155 74 ANIEALIFLL-ANPGDAILVPAPTYASYIRIARLAGGEVVRYPLYDSNDFHLDFDALEAALKEKP---KVVLHTSPHNPT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 187 GADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGmDEDAYAIRAIASAGLPALVSNSFSKIFSLYGERVGGLSVVCEda 266
Cdd:pfam00155 150 GTVATLEELEKLLDLAKEHNILLLVDEAYAGFVFG-SPDAVATRALLAEGPNLLVVGSFSKAFGLAGWRVGYILGNAA-- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 267 eiaarVLGQLKATVRRIYSSPPcfGAQVVATVLGDEALKASWLAEvdaMRTRIISMRQTLVKELKAempdRNFDYLLQQR 346
Cdd:pfam00155 227 -----VISQLRKLARPFYSSTH--LQAAAAAALSDPLLVASELEE---MRQRIKERRDYLRDGLQA----AGLSVLPSQA 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446409062 347 GMFSYTGLSEEQV----ERLRDEFGVYLIA--------SGRMCVAGLNASNVHRVAKAF 393
Cdd:pfam00155 293 GFFLLTGLDPETAkelaQVLLEEVGVYVTPgsspgvpgWLRITVAGGTEEELEELLEAI 351
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
29-395 |
1.17e-51 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 176.38 E-value: 1.17e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 29 VNLSIGLYYnedgiIPQLKTVAEAeARLNAQPHGASLYLPMEGLNTYRHTIAPLLFGADHPVLQQQRVatIQTLGGSGAL 108
Cdd:cd00609 1 IDLSIGEPD-----FPPPPEVLEA-LAAAALRAGLLGYYPDPGLPELREAIAEWLGRRGGVDVPPEEI--VVTNGAQEAL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 109 KVGADFLKRyfPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDatNGIRFNDLLATLNTLPARSIVLLHPCcHNPTGA 188
Cdd:cd00609 73 SLLLRALLN--PGDEVLVPDPTYPGYEAAARLAGAEVVPVPLDEE--GGFLLDLELLEAAKTPKTKLLYLNNP-NNPTGA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 189 DLTPSQWDAVIEIVKARDLIPFLDIAYQGFgaGMDEDAYAIRAIASAGLPALVSNSFSKIFSLYGERVGGLsvVCEDAEI 268
Cdd:cd00609 148 VLSEEELEELAELAKKHGILIISDEAYAEL--VYDGEPPPALALLDAYERVIVLRSFSKTFGLPGLRIGYL--IAPPEEL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 269 AARvlgqLKATVRRIYSSPPCFGAQVVATVLGDEAlkaswlAEVDAMRTRIISMRQTLVKELKAEMPDRNfdyLLQQRGM 348
Cdd:cd00609 224 LER----LKKLLPYTTSGPSTLSQAAAAAALDDGE------EHLEELRERYRRRRDALLEALKELGPLVV---VKPSGGF 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446409062 349 FSYTGL----SEEQVERLRDEFGVYLIASG----------RMCVAGLNAsNVHRVAKAFAA 395
Cdd:cd00609 291 FLWLDLpegdDEEFLERLLLEAGVVVRPGSafgeggegfvRLSFATPEE-ELEEALERLAE 350
|
|
| hisC |
TIGR01141 |
histidinol-phosphate aminotransferase; Alternate names: histidinol-phosphate transaminase; ... |
107-332 |
1.03e-04 |
|
histidinol-phosphate aminotransferase; Alternate names: histidinol-phosphate transaminase; imidazole acetol-phosphate transaminase Histidinol-phosphate aminotransferase is a pyridoxal-phosphate dependent enzyme. [Amino acid biosynthesis, Histidine family]
Pssm-ID: 273467 Cd Length: 350 Bit Score: 43.80 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 107 ALKVGAD----FLKRYFPDAG--VWVSDPTWENHIAIFAGAGFEVSTYPWyddATNGIRFNDLLATLNTLPARSIVLLHP 180
Cdd:TIGR01141 76 LLGNGSDeiidLLIRAFLEPGdaVLVPPPTYSMYEISAKIHGAEVVKVPL---DEDGQLDLEDILVAIDDKPKLVFLCSP 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 181 ccHNPTGADLTPSQWDAVIEIVKARDLIpFLDIAYQGFGAGMDedayairaiaSAGLPA-----LVSNSFSKIFSLYGER 255
Cdd:TIGR01141 153 --NNPTGNLFSRGDIEAVLERTPGDALV-VVDEAYGEFSGEPS----------TLPLLAeypnlIVLRTLSKAFGLAGLR 219
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446409062 256 VG-GLSvvceDAEIaARVLGQLKatvrriyssPPcFGAQVVATVLGDEALKASwlAEVDAMRTRIISMRQTLVKELKA 332
Cdd:TIGR01141 220 IGyAIA----NAEI-IDALNKVR---------AP-FNLSRLAQAAAIAALRDD--DFIEATVEEINAERERLYDGLKK 280
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09257 |
PRK09257 |
aromatic amino acid transaminase; |
1-397 |
0e+00 |
|
aromatic amino acid transaminase;
Pssm-ID: 181731 Cd Length: 396 Bit Score: 757.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 1 MFQKVDAYAGDPILSLMERFKDDSRHDKVNLSIGLYYNEDGIIPQLKTVAEAEARLNAQPhGASLYLPMEGLNTYRHTIA 80
Cdd:PRK09257 1 MFEHLEAAPADPILGLMEAFRADPRPDKVNLGVGVYKDEQGRTPVLRAVKKAEARLLETE-TTKNYLPIEGLAAYRQAVQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 81 PLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRF 160
Cdd:PRK09257 80 ELLFGADSPALAAGRVATVQTPGGTGALRVGADFLKRAFPDAKVWVSDPTWPNHRAIFEAAGLEVKTYPYYDAATKGLDF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 161 NDLLATLNTLPARSIVLLHPCCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDEDAYAIRAIASAGLPAL 240
Cdd:PRK09257 160 DAMLADLSQAPAGDVVLLHGCCHNPTGADLTPEQWDELAELLKERGLIPFLDIAYQGFGDGLEEDAYGLRAFAAAGLELL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 241 VSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLGDEALKASWLAEVDAMRTRII 320
Cdd:PRK09257 240 VASSFSKNFGLYGERVGALSVVAEDAEEADRVLSQLKATIRTNYSNPPAHGAAIVATILNDPELRAEWEAELEEMRERIK 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446409062 321 SMRQTLVKELKAEMPDRNFDYLLQQRGMFSYTGLSEEQVERLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM 397
Cdd:PRK09257 320 AMRQLLVEALKAKGPSRDFDFIARQRGMFSYSGLTPEQVDRLREEFGVYAVGSGRINVAGLNESNIDYVAEAIAAVL 396
|
|
| TyrB |
COG1448 |
Aspartate/aromatic aminotransferase [Amino acid transport and metabolism]; Aspartate/aromatic ... |
1-397 |
0e+00 |
|
Aspartate/aromatic aminotransferase [Amino acid transport and metabolism]; Aspartate/aromatic aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 441057 Cd Length: 396 Bit Score: 750.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 1 MFQKVDAYAGDPILSLMERFKDDSRHDKVNLSIGLYYNEDGIIPQLKTVAEAEARLNAQpHGASLYLPMEGLNTYRHTIA 80
Cdd:COG1448 1 MFEHLEAAPGDPILGLMEAFRADPRPNKVNLGVGVYKDEQGRTPVLRAVKAAEQRLLET-ETTKSYLPIEGDAAFNDAVQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 81 PLLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRF 160
Cdd:COG1448 80 KLLFGADSPAVAAGRVATVQTPGGTGALRVGADFLKRAFPDATVWVSDPTWPNHRAIFEAAGLEVKTYPYYDAETGGVDF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 161 NDLLATLNTLPARSIVLLHPCCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDEDAYAIRAIASAGLPAL 240
Cdd:COG1448 160 DGMLADLKQLPAGDVVLLHGCCHNPTGADLTPEQWQEVAELLKERGLIPFLDIAYQGFGDGLEEDAAGLRLFAEAGPEFL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 241 VSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLGDEALKASWLAEVDAMRTRII 320
Cdd:COG1448 240 VASSFSKNFGLYRERVGALSVVAADAEEADRVLSQLKALIRTNYSNPPDHGAAIVATILNDPELRALWEAELAEMRERIK 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446409062 321 SMRQTLVKELKAEMPDRNFDYLLQQRGMFSYTGLSEEQVERLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAVM 397
Cdd:COG1448 320 AMRQQLVDALRAKGPSRDFSFIARQRGMFSYLGLSPEQVDRLREEFGIYMVGSGRINVAGLNESNIDYVAEAIAAVL 396
|
|
| PTZ00376 |
PTZ00376 |
aspartate aminotransferase; Provisional |
2-396 |
2.12e-169 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 240390 Cd Length: 404 Bit Score: 479.42 E-value: 2.12e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 2 FQKVDAYAGDPILSLMERFKDDSRHDKVNLSIGLYYNEDGIIPQLKTVAEAEARLnAQPHGASLYLPMEGLNTYRHTIAP 81
Cdd:PTZ00376 5 FSQVPLGPPDPILGLAAAFKADPSPSKVNLGIGAYRDENGKPYVLESVRKAEKII-AEKNLDKEYLPIEGLQSFIEAAQK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 82 LLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFPDAG-VWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRF 160
Cdd:PTZ00376 84 LLFGEASYALAEKRIATVQALSGTGALRLGFEFLKRFLPAGTtVYVSNPTWPNHVNIFKSAGLNVKEYRYYDPKTKGLDF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 161 NDLLATLNTLPARSIVLLHPCCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAG-MDEDAYAIRAIASAGLPA 239
Cdd:PTZ00376 164 DGMLEDLRTAPNGSVVLLHACAHNPTGVDPTEEQWKEIADVMKRKNLIPFFDMAYQGFASGdLDKDAYAIRLFAERGVEF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 240 LVSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLGDEALKASWLAEVDAMRTRI 319
Cdd:PTZ00376 244 LVAQSFSKNMGLYGERIGALHIVCANKEEAANVLSQLKLIIRPMYSSPPIHGARIADRILSDPELRAEWLSELKEMSGRI 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446409062 320 ISMRQTLVKELKAEMPDRNFDYLLQQRGMFSYTGLSEEQVERLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAV 396
Cdd:PTZ00376 324 QNMRQLLYDELKALGSPGDWEHIINQIGMFSFTGLTKEQVERLIEKYHIYLLDNGRISVAGLTSKNVDYVAEAIHDV 400
|
|
| PLN02397 |
PLN02397 |
aspartate transaminase |
2-396 |
6.30e-160 |
|
aspartate transaminase
Pssm-ID: 215222 Cd Length: 423 Bit Score: 456.34 E-value: 6.30e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 2 FQKVDAYAGDPILSLMERFKDDSRHDKVNLSIGLYYNEDGIIPQLKTVAEAEARLNAQPHGASlYLPMEGLNTYRHTIAP 81
Cdd:PLN02397 24 FEHVEPAPPDPILGVTEAFLADPSPVKLNLGVGAYRTEEGKPVVLNVVRKAEQRLLAGSRNKE-YLPIEGLAEFNKLSAK 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 82 LLFGADHPVLQQQRVATIQTLGGSGALKVGADFLKRYFPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRFN 161
Cdd:PLN02397 103 LAYGADSPAIKENRVATVQCLSGTGSLRLGAEFLARFYPGSTIYIPNPTWGNHHNIFRDAGVPVRTYRYYDPKTRGLDFD 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 162 DLLATLNTLPARSIVLLHPCCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAG-MDEDAYAIRAIASAGLPAL 240
Cdd:PLN02397 183 GLLEDLKAAPDGSFVLLHACAHNPTGVDPTPEQWEQISDLIKSKNHLPFFDSAYQGFASGdLDADAQSVRMFVEDGHEIL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 241 VSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQLKATVRRIYSSPPCFGAQVVATVLGDEALKASWLAEVDAMRTRII 320
Cdd:PLN02397 263 VAQSYAKNMGLYGERVGALSVVCKSADVAVRVKSQLKLIARPMYSNPPIHGASIVATILGDPELFSEWTKELKGMADRII 342
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446409062 321 SMRQTLVKELKAEMPDRNFDYLLQQRGMFSYTGLSEEQVERLRDEFGVYLIASGRMCVAGLNASNVHRVAKAFAAV 396
Cdd:PLN02397 343 SMRQKLYDALEARGSPGDWSHITKQIGMFSFTGLNKEQVDRMTKEYHIYMTRDGRISMAGLSSKNVPYLADAIHAV 418
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
27-393 |
1.94e-88 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 271.49 E-value: 1.94e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 27 DKVNLSIGLYYNEdgiipQLKTVAEAEARLNAQpHGASLYLPMEGLNTYRHTIAPLLFgaDHPVLQQQRVATIQTLGGSG 106
Cdd:pfam00155 2 DKINLGSNEYLGD-----TLPAVAKAEKDALAG-GTRNLYGPTDGHPELREALAKFLG--RSPVLKLDREAAVVFGSGAG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 107 ALKVGADFLKrYFPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATNGIRFNDLLATLNTLParsIVLLHPCCHNPT 186
Cdd:pfam00155 74 ANIEALIFLL-ANPGDAILVPAPTYASYIRIARLAGGEVVRYPLYDSNDFHLDFDALEAALKEKP---KVVLHTSPHNPT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 187 GADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGmDEDAYAIRAIASAGLPALVSNSFSKIFSLYGERVGGLSVVCEda 266
Cdd:pfam00155 150 GTVATLEELEKLLDLAKEHNILLLVDEAYAGFVFG-SPDAVATRALLAEGPNLLVVGSFSKAFGLAGWRVGYILGNAA-- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 267 eiaarVLGQLKATVRRIYSSPPcfGAQVVATVLGDEALKASWLAEvdaMRTRIISMRQTLVKELKAempdRNFDYLLQQR 346
Cdd:pfam00155 227 -----VISQLRKLARPFYSSTH--LQAAAAAALSDPLLVASELEE---MRQRIKERRDYLRDGLQA----AGLSVLPSQA 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446409062 347 GMFSYTGLSEEQV----ERLRDEFGVYLIA--------SGRMCVAGLNASNVHRVAKAF 393
Cdd:pfam00155 293 GFFLLTGLDPETAkelaQVLLEEVGVYVTPgsspgvpgWLRITVAGGTEEELEELLEAI 351
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
29-395 |
1.17e-51 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 176.38 E-value: 1.17e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 29 VNLSIGLYYnedgiIPQLKTVAEAeARLNAQPHGASLYLPMEGLNTYRHTIAPLLFGADHPVLQQQRVatIQTLGGSGAL 108
Cdd:cd00609 1 IDLSIGEPD-----FPPPPEVLEA-LAAAALRAGLLGYYPDPGLPELREAIAEWLGRRGGVDVPPEEI--VVTNGAQEAL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 109 KVGADFLKRyfPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDatNGIRFNDLLATLNTLPARSIVLLHPCcHNPTGA 188
Cdd:cd00609 73 SLLLRALLN--PGDEVLVPDPTYPGYEAAARLAGAEVVPVPLDEE--GGFLLDLELLEAAKTPKTKLLYLNNP-NNPTGA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 189 DLTPSQWDAVIEIVKARDLIPFLDIAYQGFgaGMDEDAYAIRAIASAGLPALVSNSFSKIFSLYGERVGGLsvVCEDAEI 268
Cdd:cd00609 148 VLSEEELEELAELAKKHGILIISDEAYAEL--VYDGEPPPALALLDAYERVIVLRSFSKTFGLPGLRIGYL--IAPPEEL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 269 AARvlgqLKATVRRIYSSPPCFGAQVVATVLGDEAlkaswlAEVDAMRTRIISMRQTLVKELKAEMPDRNfdyLLQQRGM 348
Cdd:cd00609 224 LER----LKKLLPYTTSGPSTLSQAAAAAALDDGE------EHLEELRERYRRRRDALLEALKELGPLVV---VKPSGGF 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446409062 349 FSYTGL----SEEQVERLRDEFGVYLIASG----------RMCVAGLNAsNVHRVAKAFAA 395
Cdd:cd00609 291 FLWLDLpegdDEEFLERLLLEAGVVVRPGSafgeggegfvRLSFATPEE-ELEEALERLAE 350
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
1-371 |
4.19e-14 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 73.24 E-value: 4.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 1 MFQKVDAYAGDPILSLMERFKD--DSRHDKVNLSIGlyyNEDGIIPQ--LKTVAEAearLNAQPHGaslYLPMEGLNTYR 76
Cdd:COG0436 3 LSSRLARLPPSPIREVSALAAElkAAGEDVIDLGIG---EPDFPTPDhiREAAIEA---LDDGVTG---YTPSAGIPELR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 77 HTIAPLL---FGADhpvLQQQRVatIQTLGGSGALkvgaDFLKRYFPDAG--VWVSDPTWENHIAIFAGAGFEVSTYPWY 151
Cdd:COG0436 74 EAIAAYYkrrYGVD---LDPDEI--LVTNGAKEAL----ALALLALLNPGdeVLVPDPGYPSYRAAVRLAGGKPVPVPLD 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 152 DDATNGIRFNDLLATLnTLPARSIVLLHPccHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGmDEDAYAIRA 231
Cdd:COG0436 145 EENGFLPDPEALEAAI-TPRTKAIVLNSP--NNPTGAVYSREELEALAELAREHDLLVISDEIYEELVYD-GAEHVSILS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 232 IASAGLPALVSNSFSKIFSLYGERVGglsVVCEDAEIAARVLgQLKATVRriySSPPCFgAQVVATvlgdEALKASwLAE 311
Cdd:COG0436 221 LPGLKDRTIVINSFSKSYAMTGWRIG---YAVGPPELIAALL-KLQSNLT---SCAPTP-AQYAAA----AALEGP-QDY 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446409062 312 VDAMRTRIISMRQTLVKELKA-----EMPDRNFdYLlqqrgMFSYTGL---SEEQVERLRDEFGVYLI 371
Cdd:COG0436 288 VEEMRAEYRRRRDLLVEGLNEiglsvVKPEGAF-YL-----FADVPELgldSEEFAERLLEEAGVAVV 349
|
|
| HisC |
COG0079 |
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid ... |
120-332 |
2.41e-09 |
|
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid transport and metabolism]; Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 439849 [Multi-domain] Cd Length: 341 Bit Score: 58.22 E-value: 2.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 120 PDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDATngIRFNDLLATLNTlPARSIVLLHPccHNPTGADLTPSQWDAVI 199
Cdd:COG0079 88 PGDEVLVPEPTFSEYPIAARAAGAEVVEVPLDEDFS--LDLDALLAAITE-RTDLVFLCNP--NNPTGTLLPREELEALL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 200 EIVKARDLIpFLDIAYQGFGagmDEDAYAIRAIAS-AGLpaLVSNSFSKIFSLYGERVG-GLSvvceDAEIAARVlgqlk 277
Cdd:COG0079 163 EALPADGLV-VVDEAYAEFV---PEEDSALPLLARyPNL--VVLRTFSKAYGLAGLRLGyAIA----SPELIAAL----- 227
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 446409062 278 ATVRRIY--SSPpcfgAQVVAT-VLGDEalkaswlAEVDAMRTRIISMRQTLVKELKA 332
Cdd:COG0079 228 RRVRGPWnvNSL----AQAAALaALEDR-------AYLEETRARLRAERERLAAALRA 274
|
|
| ARO8 |
COG1167 |
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ... |
46-380 |
2.65e-09 |
|
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis
Pssm-ID: 440781 [Multi-domain] Cd Length: 471 Bit Score: 58.69 E-value: 2.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 46 LKTVAEAEARLNAQPHGASL-YLPMEGLNTYRHTIApllfgaDHpvLQQQRVAT-----IQTLGGSGALkvgaDFLKRYF 119
Cdd:COG1167 123 LAALRRALRRALRRLPPALLgYGDPQGLPELREAIA------RY--LARRGVPAspdqiLITSGAQQAL----DLALRAL 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 120 PDAG--VWVSDPTWENHIAIFAGAGFEVSTYPWYDDatnGIRFNDLLATLNTLPARSIVLLhPCCHNPTGADLTPSQWDA 197
Cdd:COG1167 191 LRPGdtVAVESPTYPGALAALRAAGLRLVPVPVDED---GLDLDALEAALRRHRPRAVYVT-PSHQNPTGATMSLERRRA 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 198 VIEIVKARD--LIpfldiayqgfgagmdEDAY---------AIRAIASAGLPALV--SNSFSKIFS--LygeRVGGLSVv 262
Cdd:COG1167 267 LLELARRHGvpII---------------EDDYdselrydgrPPPPLAALDAPGRViyIGSFSKTLApgL---RLGYLVA- 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 263 cedaeiAARVLGQLKATVRRIYSSPPCFGAQVVATVLGDealkASWLAEVDAMRTRIISMRQTLVKELKAEMPDRnFDYL 342
Cdd:COG1167 328 ------PGRLIERLARLKRATDLGTSPLTQLALAEFLES----GHYDRHLRRLRREYRARRDLLLAALARHLPDG-LRVT 396
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 446409062 343 LQQRGMFSY----TGLSEEQVERLRDEFGVyLIASGRMCVAG 380
Cdd:COG1167 397 GPPGGLHLWlelpEGVDAEALAAAALARGI-LVAPGSAFSAD 437
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
89-221 |
4.86e-08 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 52.38 E-value: 4.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 89 PVLQQQRVATIQTLGGSGALKVGADFLKRyfPDAGVWVSDPTWENHIAIFAG-AGFEVSTYPWYDDATNGIRFNDLLATL 167
Cdd:cd01494 11 RLLQPGNDKAVFVPSGTGANEAALLALLG--PGDEVIVDANGHGSRYWVAAElAGAKPVPVPVDDAGYGGLDVAILEELK 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 446409062 168 NTLPARSIVlLHPCCHNPTGADLTpsqwDAVIEIVKARDLIPFLDIAYQGFGAG 221
Cdd:cd01494 89 AKPNVALIV-ITPNTTSGGVLVPL----KEIRKIAKEYGILLLVDAASAGGASP 137
|
|
| PRK06225 |
PRK06225 |
pyridoxal phosphate-dependent aminotransferase; |
127-366 |
4.92e-08 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235749 [Multi-domain] Cd Length: 380 Bit Score: 54.37 E-value: 4.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 127 SDPTWENhIAIFAGA-GFEVSTYPWYDDATNGIRFNDLLATLNTLPARSIVLLHPccHNPTGADLTPSQWDAVIEIVKAR 205
Cdd:PRK06225 113 PDPGYLI-IDNFASRfGAEVIEVPIYSEECNYKLTPELVKENMDENTRLIYLIDP--LNPLGSSYTEEEIKEFAEIARDN 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 206 DLIPFLDIAYQGFGagmDEDAYAIRAiasAGLPALVSNSFSKIFSLYGERVGGLsvvcedaeIAAR-VLGQLKATVRRIy 284
Cdd:PRK06225 190 DAFLLHDCTYRDFA---REHTLAAEY---APEHTVTSYSFSKIFGMAGLRIGAV--------VATPdLIEVVKSIVIND- 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 285 ssppcFGAQVVATVLGDEAL--KASWLAEVdamrTRIISMRQTLVKELKAEMP---------DRNF-------------- 339
Cdd:PRK06225 255 -----LGTNVIAQEAAIAGLkvKDEWIDRI----RRTTFKNQKLIKEAVDEIEgvflpvypsHGNMmvidiseagidped 325
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 446409062 340 --DYLLqQRGMFSYTG-----------------LSEEQVERLRDEF 366
Cdd:PRK06225 326 lvEYLL-ERKIFVRQGtytskrfgdryirvsfsIPREQVEVFCEEF 370
|
|
| PRK08361 |
PRK08361 |
aspartate aminotransferase; Provisional |
162-376 |
3.49e-07 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 236248 [Multi-domain] Cd Length: 391 Bit Score: 51.80 E-value: 3.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 162 DLLATLNTLPARSIVLLHPccHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFgagMDEDAYAIRAIASAGLPALV 241
Cdd:PRK08361 157 DELLELITKRTRMIVINYP--NNPTGATLDKEVAKAIADIAEDYNIYILSDEPYEHF---LYEGAKHYPMIKYAPDNTIL 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 242 SNSFSKIFSLYGERVGGL----SVVCEDAEIAARVLGQLKATVRriyssppcfgaqvvatVLGDEAL--KASWLAeVDAM 315
Cdd:PRK08361 232 ANSFSKTFAMTGWRLGFViapeQVIKDMIKLHAYIIGNVASFVQ----------------IAGIEALrsKESWKA-VEEM 294
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446409062 316 RTRIISMRQTLVKELKaEMPDRNfdyLLQQRGMF------SYTGL-SEEQVERLRDEFGVYLI---ASGRM 376
Cdd:PRK08361 295 RKEYNERRKLVLKRLK-EMPHIK---VFEPKGAFyvfaniDETGMsSEDFAEWLLEKARVVVIpgtAFGKA 361
|
|
| PRK07337 |
PRK07337 |
pyridoxal phosphate-dependent aminotransferase; |
49-261 |
3.27e-06 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180937 Cd Length: 388 Bit Score: 48.90 E-value: 3.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 49 VAEAEARlnAQPHGASLYLPMEGLNTYRHTIAPLL---FGADHPvlqQQRVatIQTLGGSGALKVGADFLKRyfPDAGVW 125
Cdd:PRK07337 48 VVEAAAR--ALRRGVTQYTSALGLAPLREAIAAWYarrFGLDVA---PERI--VVTAGASAALLLACLALVE--RGDEVL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 126 VSDPTW---ENHIAIFAGAGFEVSTYP--------------WyDDATNGIrfndLLATlntlPArsivllhpcchNPTGA 188
Cdd:PRK07337 119 MPDPSYpcnRHFVAAAEGRPVLVPSGPaerfqltaadveaaW-GERTRGV----LLAS----PS-----------NPTGT 178
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446409062 189 DLTPSQWDAVIEIVKARDLIPFLDIAYQGFGagmdEDAYAIRAIAsAGLPALVSNSFSKIFSLYGERVGGLSV 261
Cdd:PRK07337 179 SIAPDELRRIVEAVRARGGFTIVDEIYQGLS----YDAAPVSALS-LGDDVITINSFSKYFNMTGWRLGWLVV 246
|
|
| PRK08960 |
PRK08960 |
pyridoxal phosphate-dependent aminotransferase; |
26-275 |
2.55e-05 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 181595 Cd Length: 387 Bit Score: 45.82 E-value: 2.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 26 HDKVNLSIGlyyNEDGIIPQlKTVAEAEARLNAqphGASLYLPMEGLNTYRHTIAPLL---FGADhpvLQQQRVatIQTL 102
Cdd:PRK08960 32 HDVIHLEIG---EPDFTTAE-PIVAAGQAALAA---GHTRYTAARGLPALREAIAGFYaqrYGVD---VDPERI--LVTP 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 103 GGSGALKVGADFLKRyfPDAGVWVSDPTW---ENHIAIFAGAGFEVSTYPwyddATNGIRFNDLLATLNTlpARSIVLLH 179
Cdd:PRK08960 100 GGSGALLLASSLLVD--PGKHWLLADPGYpcnRHFLRLVEGAAQLVPVGP----DSRYQLTPALVERHWN--ADTVGALV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 180 PCCHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDedayAIRAIAsAGLPALVSNSFSKIFSLYGERVGGL 259
Cdd:PRK08960 172 ASPANPTGTLLSRDELAALSQALRARGGHLVVDEIYHGLTYGVD----AASVLE-VDDDAFVLNSFSKYFGMTGWRLGWL 246
|
250
....*....|....*.
gi 446409062 260 sVVCEDAEIAARVLGQ 275
Cdd:PRK08960 247 -VAPPAAVPELEKLAQ 261
|
|
| PRK06836 |
PRK06836 |
pyridoxal phosphate-dependent aminotransferase; |
27-303 |
3.52e-05 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180720 Cd Length: 394 Bit Score: 45.57 E-value: 3.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 27 DKV-NLSIGlyyNEDgiIPQLKTVAEAEARLNAQP----HGaslYLPMEGLNTYRHTIAPLL-------FGADHPVLqqq 94
Cdd:PRK06836 33 DNVfDFSLG---NPS--VPPPAAVKEALRELAEEEdpglHG---YMPNAGYPEVREAIAESLnrrfgtpLTADHIVM--- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 95 rvatiqTLGGSGALKVgadFLKR-------------YFPDAGVWVsdptwENHiaifaGAgfeVSTYPWYDDATNGIRFN 161
Cdd:PRK06836 102 ------TCGAAGALNV---ALKAilnpgdevivfapYFVEYRFYV-----DNH-----GG---KLVVVPTDTDTFQPDLD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 162 DLLATLNtlPA-RSIVLLHPccHNPTGADLTPSQWDAVIEIVKARD--------LI---PFLDIAYQGfgagmDEDAYAI 229
Cdd:PRK06836 160 ALEAAIT--PKtKAVIINSP--NNPTGVVYSEETLKALAALLEEKSkeygrpiyLIsdePYREIVYDG-----AEVPYIF 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 230 RAIASAglpaLVSNSFSKIFSLYGERVGGLSV--VCEDAE-------IAARVLGqlkatvrriYSSPPCFGAQVVATVLG 300
Cdd:PRK06836 231 KYYDNS----IVVYSFSKSLSLPGERIGYIAVnpEMEDADdlvaalvFANRILG---------FVNAPALMQRVVAKCLD 297
|
...
gi 446409062 301 DEA 303
Cdd:PRK06836 298 ATV 300
|
|
| PRK05764 |
PRK05764 |
aspartate aminotransferase; Provisional |
124-335 |
5.53e-05 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 235596 Cd Length: 393 Bit Score: 44.73 E-value: 5.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 124 VWVSDPTW---ENHIAIFAGAGFEVSTypwydDATNG--IRFNDLLATLnTLPARSIVLLHPccHNPTGADLTPSQWDAV 198
Cdd:PRK05764 118 VIIPAPYWvsyPEMVKLAGGVPVFVPT-----GEENGfkLTVEQLEAAI-TPKTKALILNSP--SNPTGAVYSPEELEAI 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 199 IEIVKARDLIPFLDIAYQGFGAGmDEDAYAIrAIASAGLP--ALVSNSFSKIFSLYGERVGGLSVVCEDAEIAARVLGQl 276
Cdd:PRK05764 190 ADVAVEHDIWVLSDEIYEKLVYD-GAEFTSI-ASLSPELRdrTITVNGFSKAYAMTGWRLGYAAGPKELIKAMSKLQSH- 266
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 446409062 277 katvrrIYSSPPCFgAQVVATvlgdEALKASWlAEVDAMRTRIISMRQTLVKELKaEMP 335
Cdd:PRK05764 267 ------STSNPTSI-AQYAAV----AALNGPQ-DEVEEMRQAFEERRDLMVDGLN-EIP 312
|
|
| PRK07681 |
PRK07681 |
LL-diaminopimelate aminotransferase; |
14-278 |
1.01e-04 |
|
LL-diaminopimelate aminotransferase;
Pssm-ID: 181081 Cd Length: 399 Bit Score: 44.03 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 14 LSLMERFKDDSRHDKVNLSIGlyyNEDgiIPQLKTVAEAEARLNAQP--HGASLylpmEGLNTYRHTIAPLlFGADHPVL 91
Cdd:PRK07681 20 LGAYKKEKIAAGHKMIDLSIG---NPD--MPPADFVREEMVHTANQKesYGYTL----SGIQEFHEAVTEY-YNNTHNVI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 92 QQQRVATIQTLGGSGALKvgadFLKRYFPDAG--VWVSDPTWENHIAIFAGAGFEVSTYPWYDDatngirfNDLLATLNT 169
Cdd:PRK07681 90 LNADKEVLLLMGSQDGLV----HLPMVYANPGdiILVPDPGYTAYETGIQMAGATSYYMPLKKE-------NDFLPDLEL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 170 LP------ARSIVLLHPccHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAGMDEdAYAIRAIASAGLPALVSN 243
Cdd:PRK07681 159 IPeeiadkAKMMILNFP--GNPVPAMAHEDFFKEVIAFAKKHNIIVVHDFAYAEFYFDGNK-PISFLSVPGAKEVGVEIN 235
|
250 260 270
....*....|....*....|....*....|....*
gi 446409062 244 SFSKIFSLYGERVGGLsvvCEDAEIaARVLGQLKA 278
Cdd:PRK07681 236 SLSKSYSLAGSRIGYM---IGNEEI-VRALTQFKS 266
|
|
| hisC |
TIGR01141 |
histidinol-phosphate aminotransferase; Alternate names: histidinol-phosphate transaminase; ... |
107-332 |
1.03e-04 |
|
histidinol-phosphate aminotransferase; Alternate names: histidinol-phosphate transaminase; imidazole acetol-phosphate transaminase Histidinol-phosphate aminotransferase is a pyridoxal-phosphate dependent enzyme. [Amino acid biosynthesis, Histidine family]
Pssm-ID: 273467 Cd Length: 350 Bit Score: 43.80 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 107 ALKVGAD----FLKRYFPDAG--VWVSDPTWENHIAIFAGAGFEVSTYPWyddATNGIRFNDLLATLNTLPARSIVLLHP 180
Cdd:TIGR01141 76 LLGNGSDeiidLLIRAFLEPGdaVLVPPPTYSMYEISAKIHGAEVVKVPL---DEDGQLDLEDILVAIDDKPKLVFLCSP 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 181 ccHNPTGADLTPSQWDAVIEIVKARDLIpFLDIAYQGFGAGMDedayairaiaSAGLPA-----LVSNSFSKIFSLYGER 255
Cdd:TIGR01141 153 --NNPTGNLFSRGDIEAVLERTPGDALV-VVDEAYGEFSGEPS----------TLPLLAeypnlIVLRTLSKAFGLAGLR 219
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446409062 256 VG-GLSvvceDAEIaARVLGQLKatvrriyssPPcFGAQVVATVLGDEALKASwlAEVDAMRTRIISMRQTLVKELKA 332
Cdd:TIGR01141 220 IGyAIA----NAEI-IDALNKVR---------AP-FNLSRLAQAAAIAALRDD--DFIEATVEEINAERERLYDGLKK 280
|
|
| PRK07777 |
PRK07777 |
putative succinyldiaminopimelate transaminase DapC; |
25-273 |
1.19e-04 |
|
putative succinyldiaminopimelate transaminase DapC;
Pssm-ID: 236095 [Multi-domain] Cd Length: 387 Bit Score: 43.87 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 25 RHDKVNLSIGlYYNEDGIIPQLKTVAEAEArlnaqpHGASLYLPMEGLNTYRHTIAPllfgadhpvlQQQRVATIQ---- 100
Cdd:PRK07777 23 RTGAVNLGQG-FPDEDGPPEMLEAAQEAIA------GGVNQYPPGPGIPELRAAIAA----------QRRRRYGLEydpd 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 101 -----TLGGSGAlkVGADFLKRYFPDAGVWVSDPTWENHIAIFAGAGFEVSTYPWYDDAtNGIRFN-DLLATLNTLPARS 174
Cdd:PRK07777 86 tevlvTVGATEA--IAAAVLGLVEPGDEVLLIEPYYDSYAAVIAMAGAHRVPVPLVPDG-RGFALDlDALRAAVTPRTRA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 175 IVLLHPccHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFgagMDEDAyaiRAIASAGLPAL------VSnSFSKI 248
Cdd:PRK07777 163 LIVNSP--HNPTGTVLTAAELAAIAELAVEHDLLVITDEVYEHL---VFDGA---RHLPLATLPGMrertvtIS-SAAKT 233
|
250 260
....*....|....*....|....*
gi 446409062 249 FSLYGERVGGlsvVCEDAEIAARVL 273
Cdd:PRK07777 234 FNVTGWKIGW---ACGPAPLIAAVR 255
|
|
| PRK07324 |
PRK07324 |
transaminase; Validated |
94-257 |
1.45e-04 |
|
transaminase; Validated
Pssm-ID: 235989 Cd Length: 373 Bit Score: 43.39 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 94 QRVATIQTLGGSGAlkVGADFLKRYF---PDAGVWVSDPTWENHIAIFAGAGFEVSTYP------WYDDAtngirfNDL- 163
Cdd:PRK07324 76 QNVKPENILQTNGA--TGANFLVLYAlvePGDHVISVYPTYQQLYDIPESLGAEVDYWQlkeengWLPDL------DELr 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 164 -LATLNTlpaRSIVLLHPccHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFGAgmDEDAYAI-----RAIASagl 237
Cdd:PRK07324 148 rLVRPNT---KLICINNA--NNPTGALMDRAYLEEIVEIARSVDAYVLSDEVYRPLDE--DGSTPSIadlyeKGIST--- 217
|
170 180
....*....|....*....|
gi 446409062 238 palvsNSFSKIFSLYGERVG 257
Cdd:PRK07324 218 -----NSMSKTYSLPGIRVG 232
|
|
| PRK05166 |
PRK05166 |
histidinol-phosphate transaminase; |
162-326 |
2.91e-04 |
|
histidinol-phosphate transaminase;
Pssm-ID: 179950 Cd Length: 371 Bit Score: 42.43 E-value: 2.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 162 DLLATLNTLPARSIVLLHPCCHNPTGADLTPSQWDAVIEIVKARDLIpFLDIAYQGFGAGmDEDAYAIRAIASAGLPALV 241
Cdd:PRK05166 148 DLDALCAAVARAPRMLMFSNPSNPVGSWLTADQLARVLDATPPETLI-VVDEAYAEYAAG-DDYPSALTLLKARGLPWIV 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 242 SNSFSKIFSLYGERVG-GLSvvcEDAEiaarvLGQLKATVRRIYSSPPCfgAQVVA-TVLGDEALKASWLAEVDAMRTRi 319
Cdd:PRK05166 226 LRTFSKAYGLAGLRVGyGLV---SDPE-----LVGLLDRVRTPFNVNGA--AQAAAlAALDDEEHLAKGVALALAERER- 294
|
....*..
gi 446409062 320 isMRQTL 326
Cdd:PRK05166 295 --LKKEL 299
|
|
| PRK07682 |
PRK07682 |
aminotransferase; |
173-362 |
1.05e-03 |
|
aminotransferase;
Pssm-ID: 181082 [Multi-domain] Cd Length: 378 Bit Score: 40.87 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 173 RSIVLLHPccHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFgaGMDEDAYAIRAIASAGLPALVSNSFSKIFSLY 252
Cdd:PRK07682 156 KAILLCSP--NNPTGAVLNKSELEEIAVIVEKHDLIVLSDEIYAEL--TYDEAYTSFASIKGMRERTILISGFSKGFAMT 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 253 GERVGglsVVCEDAEIAARVLgqlkatvrRIYS-SPPCfgAQVVATVLGDEALKASwLAEVDAMRTRIISMRQTLVKELK 331
Cdd:PRK07682 232 GWRLG---FIAAPVYFSEAML--------KIHQySMMC--APTMAQFAALEALRAG-NDDVIRMRDSYRKRRNFFVTSFN 297
|
170 180 190
....*....|....*....|....*....|....*..
gi 446409062 332 -----AEMPDRNFdYLLQQrgmFSYTGLSEEQ-VERL 362
Cdd:PRK07682 298 eigltCHVPGGAF-YAFPS---ISSTGLSSEEfAEQL 330
|
|
| PRK06348 |
PRK06348 |
pyridoxal phosphate-dependent aminotransferase; |
162-257 |
1.77e-03 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180537 Cd Length: 384 Bit Score: 40.09 E-value: 1.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 162 DLLATLNTLPARSIVLLHPccHNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFgaGMDEDAYAIRAIASAGLPALV 241
Cdd:PRK06348 153 KKLEALITSKTKAIILNSP--NNPTGAVFSKETLEEIAKIAIEYDLFIISDEVYDGF--SFYEDFVPMATLAGMPERTIT 228
|
90
....*....|....*.
gi 446409062 242 SNSFSKIFSLYGERVG 257
Cdd:PRK06348 229 FGSFSKDFAMTGWRIG 244
|
|
| PRK07568 |
PRK07568 |
pyridoxal phosphate-dependent aminotransferase; |
173-335 |
2.59e-03 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 181036 Cd Length: 397 Bit Score: 39.83 E-value: 2.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 173 RSIVLLHPCchNPTGADLTPSQWDAVIEIVKARDLIPFLDIAYQGFgagmdedAYAIRAIASAG-LPALVSN-----SFS 246
Cdd:PRK07568 164 KAILISNPG--NPTGVVYTKEELEMLAEIAKKHDLFLISDEVYREF-------VYDGLKYTSALsLEGLEDRviiidSVS 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409062 247 KIFSLYGERVGglSVVCEDAEIAARVLGQLKAtvrRIysSPPCFgAQVVATVLGDeaLKASWLAEV-DAMRTRiismRQT 325
Cdd:PRK07568 235 KRYSACGARIG--CLISKNKELIAAAMKLCQA---RL--SPPTL-EQIGAAALLD--TPESYFDEVrEEYKKR----RDI 300
|
170
....*....|
gi 446409062 326 LVKELKaEMP 335
Cdd:PRK07568 301 LYEELN-KIP 309
|
|
| |
