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Conserved domains on  [gi|446411665|ref|WP_000489520|]
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MULTISPECIES: HAMP domain-containing sensor histidine kinase [Streptococcus]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

EC:  2.7.13.3
Gene Ontology:  GO:0004673|GO:0007165|GO:0005524|GO:0000160|GO:0016020|GO:0000155
PubMed:  11489844|18076326|10966457|11406410|12372152|8029829

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
140-409 1.93e-37

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 138.50  E-value: 1.93e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 140 DYLVVFLDTTNQYLDNQRLLQLSIWMSLASFIVFMVIVSVLSGRVILPFVANYEKQRRFITNAGHELKTPLAIISANNEL 219
Cdd:COG0642   55 ALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLEL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 220 VEMMSGE--SEWTKSTNDQIQRLTGLINGMVSLARFE-EQPDISMVDLDFSHITKDAAEDFKGPIIKDGKDFIMSIQPGI 296
Cdd:COG0642  135 LLEELDEeqREYLETILRSADRLLRLINDLLDLSRLEaGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDL 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 297 -HVKAEEKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSrlRRAKLEVSNTyknGKDI---DYSKFFERFYREDESHNNK 372
Cdd:COG0642  215 pTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREG--DRVRISVEDT---GPGIppeDLERIFEPFFRTDPSRRGG 289

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 446411665 373 ksGYGIGLSIVTSLVHLFKGSIDVNYKHDT-ITFVIYI 409
Cdd:COG0642  290 --GTGLGLAIVKRIVELHGGTIEVESEPGKgTTFTVTL 325
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
140-409 1.93e-37

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 138.50  E-value: 1.93e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 140 DYLVVFLDTTNQYLDNQRLLQLSIWMSLASFIVFMVIVSVLSGRVILPFVANYEKQRRFITNAGHELKTPLAIISANNEL 219
Cdd:COG0642   55 ALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLEL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 220 VEMMSGE--SEWTKSTNDQIQRLTGLINGMVSLARFE-EQPDISMVDLDFSHITKDAAEDFKGPIIKDGKDFIMSIQPGI 296
Cdd:COG0642  135 LLEELDEeqREYLETILRSADRLLRLINDLLDLSRLEaGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDL 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 297 -HVKAEEKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSrlRRAKLEVSNTyknGKDI---DYSKFFERFYREDESHNNK 372
Cdd:COG0642  215 pTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREG--DRVRISVEDT---GPGIppeDLERIFEPFFRTDPSRRGG 289

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 446411665 373 ksGYGIGLSIVTSLVHLFKGSIDVNYKHDT-ITFVIYI 409
Cdd:COG0642  290 --GTGLGLAIVKRIVELHGGTIEVESEPGKgTTFTVTL 325
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 192-407 8.03e-18

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 85.13  E-value: 8.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665  192 YEKQRRFITNAGHELKTPLAIISANNE--LVEMMSGES--EWTKSTNDQIQRLTGLINGMVSLARFEE---QPDISMVDL 264
Cdd:TIGR01386 238 FQRLSQFSADLAHELRTPLTNLLGQTQvaLSQPRTGEEyrEVLESNLEELERLSRMVSDMLFLARADNgqlALERVRLDL 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665  265 dfshitkdAAE-----DFKGPIIKDgKDFIMSIQPGIHVKAEEKSLFELVTLLVDNANKYCDPMGTVTVKLSRssRLRRA 339
Cdd:TIGR01386 318 --------AAElakvaEYFEPLAEE-RGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIER--RSDEV 386

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446411665  340 KLEVSNTYKNGKDIDYSKFFERFYREDESHNNKKSGYGIGLSIVTSLVHLFKGSIDVNYKHDTITFVI 407
Cdd:TIGR01386 387 RVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGKTRFIL 454
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 156-396 7.69e-15

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 76.04  E-value: 7.69e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 156 QRLLQLSIWMSLASFIVFMVIV---------------SVLSG-RVILPFVANYE-----------------KQ--RRFIT 200
Cdd:PRK11100 182 RRILWAGALLLGIALLIGAGVVwwlnrsirrltryadAVTEGkPVPLPKLGSSElrelaqalesmrvklegKAyvEQYVQ 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 201 NAGHELKTPLAIISANNELVEM-MSGE--SEWTKSTNDQIQRLTGLINGMVSLARFEEQPDIS-MVDLDFSHITKDAAED 276
Cdd:PRK11100 262 TLTHELKSPLAAIRGAAELLQEdPPPEdrARFTGNILTQSARLQQLIDRLLELARLEQRQELEvLEPVALAALLEELVEA 341

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 277 FKgpIIKDGKDFIMSIQP-GIHVKAEEKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSrlRRAKLEVSNTyknGKDI-D 354
Cdd:PRK11100 342 RE--AQAAAKGITLRLRPdDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDG--EQVALSVEDQ---GPGIpD 414

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 446411665 355 Y--SKFFERFYREDESHNNKKSGyGIGLSIVTSLVHLFKGSIDV 396
Cdd:PRK11100 415 YalPRIFERFYSLPRPANGRKST-GLGLAFVREVARLHGGEVTL 457
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 300-407 3.96e-13

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 65.36  E-value: 3.96e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665   300 AEEKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSRlrRAKLEVSNtykNGKDI---DYSKFFERFYREDEShNNKKSGY 376
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGD--HVEITVED---NGPGIppeDLEKIFEPFFRTDKR-SRKIGGT 74

                           90       100       110
                   ....*....|....*....|....*....|....
gi 446411665   377 GIGLSIVTSLVHLFKGSIDVNYKHD---TITFVI 407
Cdd:smart00387  75 GLGLSIVKKLVELHGGEISVESEPGggtTFTITL 108
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 305-409 7.53e-13

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 64.16  E-value: 7.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 305 LFELVTLLVDNANKYCDPMGTVTVKLSRSSRlrRAKLEVSNtykNGKDIDYS---KFFERFYREDESHnnKKSGYGIGLS 381
Cdd:cd00075    1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGD--GVVLEVED---NGPGIPEEdleRIFERFYRGDKSR--EGGGTGLGLA 73

                         90       100       110
                 ....*....|....*....|....*....|
gi 446411665 382 IVTSLVHLFKGSIDVNYKHD--TiTFVIYI 409
Cdd:cd00075   74 IVRRIVEAHGGRITVESEPGggT-TFTVTL 102
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 302-407 1.55e-12

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 63.54  E-value: 1.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665  302 EKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSRLRrakLEVSNtykNGKDI---DYSKFFERFYREDEShnnKKSGYGI 378
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGELT---LTVED---NGIGIppeDLPRIFEPFSTADKR---GGGGTGL 73

                          90       100       110
                  ....*....|....*....|....*....|..
gi 446411665  379 GLSIVTSLVHLFKGSIDVNYKHD---TITFVI 407
Cdd:pfam02518  74 GLSIVRKLVELLGGTITVESEPGggtTVTLTL 105
ArsS_fam_HK NF038389
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ...
 198-407 9.03e-03

ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.


Pssm-ID: 468500 [Multi-domain]  Cd Length: 402  Bit Score: 37.90  E-value: 9.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 198 FITNAGHELKTPLA---IISannelvEMMsgESEWTKSTNDQI-QRLTGLINgmvSLARFEEQpdismvdldfshITKDA 273
Cdd:NF038389 209 FLRNIMHELKTPITkgrIVA------EML--EDEKQKERLISIfERLESLIN---EFAKIEQL------------TSKNY 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 274 AEDFK----GPIIKDGKDFIM--SIQPGIHVKAEEKSL---FELVTL----LVDNANKYcDPMGTVTVKLSRSsrlrraK 340
Cdd:NF038389 266 KLNKKeyrlSDIIDEAIDMLMidDSSVIIKVSLEDFKLnvdFELFSLaiknLIDNAIKY-SPDKKVTIEIKGD------K 338

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446411665 341 LEVSNtykNGKDIDY--SKFFERFYREdesHNNKKSGYGIGLSIVTSLVHLFKGSIDVNYKHDTITFVI 407
Cdd:NF038389 339 IEFKN---KGEPLEEplEYYFEPFFKG---NEKSKSGFGLGLYIVKNILKAHGFKLEYEYENGYNIFII 401
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
140-409 1.93e-37

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 138.50  E-value: 1.93e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 140 DYLVVFLDTTNQYLDNQRLLQLSIWMSLASFIVFMVIVSVLSGRVILPFVANYEKQRRFITNAGHELKTPLAIISANNEL 219
Cdd:COG0642   55 ALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLEL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 220 VEMMSGE--SEWTKSTNDQIQRLTGLINGMVSLARFE-EQPDISMVDLDFSHITKDAAEDFKGPIIKDGKDFIMSIQPGI 296
Cdd:COG0642  135 LLEELDEeqREYLETILRSADRLLRLINDLLDLSRLEaGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDL 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 297 -HVKAEEKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSrlRRAKLEVSNTyknGKDI---DYSKFFERFYREDESHNNK 372
Cdd:COG0642  215 pTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREG--DRVRISVEDT---GPGIppeDLERIFEPFFRTDPSRRGG 289

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 446411665 373 ksGYGIGLSIVTSLVHLFKGSIDVNYKHDT-ITFVIYI 409
Cdd:COG0642  290 --GTGLGLAIVKRIVELHGGTIEVESEPGKgTTFTVTL 325
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
68-396 3.62e-33

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 128.13  E-value: 3.62e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665  68 LSTDAIFQFRYFSARTDAKGNVTSFDSRNIFEVSDRQIKNYAKRIVSQNSDSGHITYNFSTYSYLLKKVGKNDYLVVFLD 147
Cdd:COG5002   38 LLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAAL 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 148 TTNQYLDNQRLLQLSIWMSLASFIVFMVIVSVLSGRVILPFVANYEKQRRFITNAGHELKTPLAIISANNELVEMMSGES 227
Cdd:COG5002  118 LLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADD 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 228 -----EWTKSTNDQIQRLTGLINGMVSLARFEEQP-DISMVDLDFSHITKDAAEDFKGPIIKDGKDFIMSIQPG-IHVKA 300
Cdd:COG5002  198 peerrEYLEIILEEAERLSRLVNDLLDLSRLESGElKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDpLLVLG 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 301 EEKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSRlrRAKLEVSNTyknGKDI---DYSKFFERFYREDESHNNKKSGYG 377
Cdd:COG5002  278 DPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDD--QVRISVRDT---GIGIpeeDLPRIFERFYRVDKSRSRETGGTG 352

                        330
                 ....*....|....*....
gi 446411665 378 IGLSIVTSLVHLFKGSIDV 396
Cdd:COG5002  353 LGLAIVKHIVEAHGGRIWV 371
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
193-396 2.96e-31

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 119.24  E-value: 2.96e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 193 EKQRRFITNAGHELKTPLAIISANNELVEMMSGES-----EWTKSTNDQIQRLTGLINGMVSLARFE-EQPDISMVDLDF 266
Cdd:COG2205   14 RLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSpeerrELLEIIRESAERLLRLIEDLLDLSRLEsGKLSLELEPVDL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 267 SHITKDAAEDFKGPIIKDGKDFIMSIQPG-IHVKAEEKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSrlRRAKLEVSN 345
Cdd:COG2205   94 AELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREG--DGVRISVSD 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446411665 346 tykNGKDI---DYSKFFERFYREDESHNnkKSGYGIGLSIVTSLVHLFKGSIDV 396
Cdd:COG2205  172 ---NGPGIpeeELERIFERFYRGDNSRG--EGGTGLGLAIVKRIVEAHGGTIWV 220
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 192-407 8.03e-18

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 85.13  E-value: 8.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665  192 YEKQRRFITNAGHELKTPLAIISANNE--LVEMMSGES--EWTKSTNDQIQRLTGLINGMVSLARFEE---QPDISMVDL 264
Cdd:TIGR01386 238 FQRLSQFSADLAHELRTPLTNLLGQTQvaLSQPRTGEEyrEVLESNLEELERLSRMVSDMLFLARADNgqlALERVRLDL 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665  265 dfshitkdAAE-----DFKGPIIKDgKDFIMSIQPGIHVKAEEKSLFELVTLLVDNANKYCDPMGTVTVKLSRssRLRRA 339
Cdd:TIGR01386 318 --------AAElakvaEYFEPLAEE-RGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIER--RSDEV 386

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446411665  340 KLEVSNTYKNGKDIDYSKFFERFYREDESHNNKKSGYGIGLSIVTSLVHLFKGSIDVNYKHDTITFVI 407
Cdd:TIGR01386 387 RVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGKTRFIL 454
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 156-396 7.69e-15

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 76.04  E-value: 7.69e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 156 QRLLQLSIWMSLASFIVFMVIV---------------SVLSG-RVILPFVANYE-----------------KQ--RRFIT 200
Cdd:PRK11100 182 RRILWAGALLLGIALLIGAGVVwwlnrsirrltryadAVTEGkPVPLPKLGSSElrelaqalesmrvklegKAyvEQYVQ 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 201 NAGHELKTPLAIISANNELVEM-MSGE--SEWTKSTNDQIQRLTGLINGMVSLARFEEQPDIS-MVDLDFSHITKDAAED 276
Cdd:PRK11100 262 TLTHELKSPLAAIRGAAELLQEdPPPEdrARFTGNILTQSARLQQLIDRLLELARLEQRQELEvLEPVALAALLEELVEA 341

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 277 FKgpIIKDGKDFIMSIQP-GIHVKAEEKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSrlRRAKLEVSNTyknGKDI-D 354
Cdd:PRK11100 342 RE--AQAAAKGITLRLRPdDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDG--EQVALSVEDQ---GPGIpD 414

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 446411665 355 Y--SKFFERFYREDESHNNKKSGyGIGLSIVTSLVHLFKGSIDV 396
Cdd:PRK11100 415 YalPRIFERFYSLPRPANGRKST-GLGLAFVREVARLHGGEVTL 457
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
118-383 1.59e-14

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 74.66  E-value: 1.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 118 DSGHITYNFSTYSYLLKKVGKNDylvvFLDTTNQYLDNQRLLQLSIwMSLASFIVFMVIVSVLSGRVIlpfvanyEKQRR 197
Cdd:PRK11006 138 DNGQNILNLLRYPEFTQYLKTRD----FSRPLTLVLNNGRHLEIRV-MPYTEGQLLMVARDVTQMHQL-------EGARR 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 198 -FITNAGHELKTPLAIISAnneLVEMMSGE----SEWTKSTN---DQIQRLTGLINGMVSLARFEEQPDISM---VDL-D 265
Cdd:PRK11006 206 nFFANVSHELRTPLTVLQG---YLEMMQDQplegALREKALHtmrEQTQRMEGLVKQLLTLSKIEAAPTIDLnekVDVpM 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 266 FSHITKDAAEDfkgpiIKDGK-DFIMSIQPGIHVKAEEKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSRlrRAKLEVS 344
Cdd:PRK11006 283 MLRVLEREAQT-----LSQGKhTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQ--GAEFSVE 355

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 446411665 345 NtykNGKDID---YSKFFERFYREDESHNNKKSGYGIGLSIV 383
Cdd:PRK11006 356 D---NGPGIApehIPRLTERFYRVDKARSRQTGGSGLGLAIV 394
PRK10604 PRK10604
sensor protein RstB; Provisional
 199-397 2.47e-13

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 71.17  E-value: 2.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 199 ITNAGHELKTPLAIISANNELVEMMSgESEwTKSTNDQIQRLTGLINGMVSLARFEE-QPDISMVDLDFSHITKDAAEDF 277
Cdd:PRK10604 216 IDGIAHELRTPLVRLRYRLEMSDNLS-AAE-SQALNRDIGQLEALIEELLTYARLDRpQNELHLSEPDLPAWLSTHLADI 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 278 KgpIIKDGKDFIMSIQPGIHVKAEEKSLFE-LVTLLVDNANKYCDpmGTVTVKLSRSSRlrRAKLEVSNtykNGKDI--- 353
Cdd:PRK10604 294 Q--AVTPEKTVRLDTPHQGDYGALDMRLMErVLDNLLNNALRYAH--SRVRVSLLLDGN--QACLIVED---DGPGIppe 364

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 446411665 354 DYSKFFERFYREDESHNNKKSGYGIGLSIVTSLVHLFKGSIDVN 397
Cdd:PRK10604 365 ERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCD 408
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 300-407 3.96e-13

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 65.36  E-value: 3.96e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665   300 AEEKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSRlrRAKLEVSNtykNGKDI---DYSKFFERFYREDEShNNKKSGY 376
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGD--HVEITVED---NGPGIppeDLEKIFEPFFRTDKR-SRKIGGT 74

                           90       100       110
                   ....*....|....*....|....*....|....
gi 446411665   377 GIGLSIVTSLVHLFKGSIDVNYKHD---TITFVI 407
Cdd:smart00387  75 GLGLSIVKKLVELHGGEISVESEPGggtTFTITL 108
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 305-409 7.53e-13

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 64.16  E-value: 7.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 305 LFELVTLLVDNANKYCDPMGTVTVKLSRSSRlrRAKLEVSNtykNGKDIDYS---KFFERFYREDESHnnKKSGYGIGLS 381
Cdd:cd00075    1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGD--GVVLEVED---NGPGIPEEdleRIFERFYRGDKSR--EGGGTGLGLA 73

                         90       100       110
                 ....*....|....*....|....*....|
gi 446411665 382 IVTSLVHLFKGSIDVNYKHD--TiTFVIYI 409
Cdd:cd00075   74 IVRRIVEAHGGRITVESEPGggT-TFTVTL 102
PRK10337 PRK10337
sensor protein QseC; Provisional
 194-383 1.46e-12

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 68.91  E-value: 1.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 194 KQRRFITNAGHELKTPLAIISANNELVEMMSGESEWTKSTNDQ----IQRLTGLINGMVSLARF--EEQPDiSMVDLDFS 267
Cdd:PRK10337 236 RERRFTSDAAHELRSPLAALKVQTEVAQLSDDDPQARKKALLQlhagIDRATRLVDQLLTLSRLdsLDNLQ-DVAEIPLE 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 268 HITKDAAEDFKGPIIKDGKDFIMSIqPGIHVKAEEKSLfeLVTLLV----DNANKYCDPMGTVTVKLSRSSrlrrakLEV 343
Cdd:PRK10337 315 DLLQSAVMDIYHTAQQAGIDVRLTL-NAHPVIRTGQPL--LLSLLVrnllDNAIRYSPQGSVVDVTLNARN------FTV 385

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446411665 344 SNtykNGKDID---YSKFFERFYREDESHnnkKSGYGIGLSIV 383
Cdd:PRK10337 386 RD---NGPGVTpeaLARIGERFYRPPGQE---ATGSGLGLSIV 422
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 302-407 1.55e-12

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 63.54  E-value: 1.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665  302 EKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSRLRrakLEVSNtykNGKDI---DYSKFFERFYREDEShnnKKSGYGI 378
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGELT---LTVED---NGIGIppeDLPRIFEPFSTADKR---GGGGTGL 73

                          90       100       110
                  ....*....|....*....|....*....|..
gi 446411665  379 GLSIVTSLVHLFKGSIDVNYKHD---TITFVI 407
Cdd:pfam02518  74 GLSIVRKLVELLGGTITVESEPGggtTVTLTL 105
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 204-396 3.64e-12

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 67.29  E-value: 3.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 204 HELKTPLAIISANNELVEMMSGES---------EWTKSTNDQIQRLTGLINGMVSLARFeeqPDISMVDLDFSHITKDAA 274
Cdd:COG5000  210 HEIKNPLTPIQLSAERLRRKLADKleedredleRALDTIIRQVDRLKRIVDEFLDFARL---PEPQLEPVDLNELLREVL 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 275 EDFKGPIIKDGKDFIMSIQPGI-HVKAEEKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSRlrRAKLEVSNtykNGKDI 353
Cdd:COG5000  287 ALYEPALKEKDIRLELDLDPDLpEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDG--RVRIEVSD---NGPGI 361

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 446411665 354 ---DYSKFFERFYredeSHnnKKSGYGIGLSIVTSLVHLFKGSIDV 396
Cdd:COG5000  362 peeVLERIFEPFF----TT--KPKGTGLGLAIVKKIVEEHGGTIEL 401
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 202-396 4.16e-12

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 67.50  E-value: 4.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 202 AGHELKTPLAIISANNELVEMMSGES------EWTKSTNDQIQRLTGLINGMVSLARFEEQPdISMVDLDFSHITKDAAE 275
Cdd:COG4251  289 ASHDLREPLRKISGFSQLLEEDYGDKldeegrEYLERIRDAAERMQALIDDLLAYSRVGRQE-LEFEPVDLNELLEEVLE 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 276 DFKGPIikDGKDFIMSIQPGIHVKAEEKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSRLRRAKLEVSNtykNGKDIDy 355
Cdd:COG4251  368 DLEPRI--EERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGEPPRIEIGAEREGGEWVFSVRD---NGIGID- 441

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 446411665 356 SKFFER----FYRedeSHNNKK-SGYGIGLSIVTSLVHLFKGSIDV 396
Cdd:COG4251  442 PEYAEKifeiFQR---LHSRDEyEGTGIGLAIVKKIVERHGGRIWV 484
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
192-407 2.13e-10

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 62.10  E-value: 2.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 192 YEKQRRFITNAGHELKTPLAIISANNELVEMMS-GESEWTK---STNDQIQRLTGLINGMVSLARFEEQ---PDISMVDL 264
Cdd:PRK09835 259 FTRQSNFSADIAHEIRTPITNLITQTEIALSQSrSQKELEDvlySNLEELTRMAKMVSDMLFLAQADNNqliPEKKMLDL 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 265 -DFSHITKDA----AEDFKGPIIKDGKdfimsiqpGIHVKAEEKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSRLrrA 339
Cdd:PRK09835 339 aDEVGKVFDFfeawAEERGVELRFVGD--------PCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQ--V 408

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446411665 340 KLEVSNTyknGKDI---DYSKFFERFYREDESHNNKKSGYGIGLSIVTSLVHLFKGSIDVNYKHDTITFVI 407
Cdd:PRK09835 409 QLVVENP---GTPIapeHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVI 476
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 305-394 9.05e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 55.87  E-value: 9.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 305 LFELVTLLVDNANKYCDPMGTVTVKLSRSSrlrRAKLEVSNtykNGKDIDYS---KFFERFYREDESHnnkKSGYGIGLS 381
Cdd:cd16940   14 LFLLLRNLVDNAVRYSPQGSRVEIKLSADD---GAVIRVED---NGPGIDEEeleALFERFYRSDGQN---YGGSGLGLS 84

                         90
                 ....*....|...
gi 446411665 382 IVTSLVHLFKGSI 394
Cdd:cd16940   85 IVKRIVELHGGQI 97
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
193-394 3.33e-09

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 58.49  E-value: 3.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 193 EKQRR-FITNAGHELKTPLAIISAnnELVEMMSGESEWTKSTNDQIQ----RLTGLINGMVSLarfeeqpdiSMVD---- 263
Cdd:PRK10549 237 EQMRRdFMADISHELRTPLAVLRG--ELEAIQDGVRKFTPESVASLQaevgTLTKLVDDLHQL---------SLSDegal 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 264 ------LDFSHITKDAAEDFKGPIIKDGKDFIMSIQPGIHVKAEEKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSRlr 337
Cdd:PRK10549 306 ayrktpVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDK-- 383

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446411665 338 RAKLEVSNTYKNGKDIDYSKFFERFYREDESHNNKKSGYGIGLSIVTSLVHLFKGSI 394
Cdd:PRK10549 384 TLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRI 440
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
204-396 1.09e-08

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 56.39  E-value: 1.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 204 HELKTPLAIISANNELVEMMSGESEWTKSTN---DQIQRLTGLINGMVSLARfEEQPDISMVDLD--FSHITKDAAEDFK 278
Cdd:COG3852  144 HEIRNPLTGIRGAAQLLERELPDDELREYTQliiEEADRLNNLVDRLLSFSR-PRPPEREPVNLHevLERVLELLRAEAP 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 279 gpiikDGKDFIMSIQPGI-HVKAEEKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSRLRRAKLEVSNTYK-----NGKD 352
Cdd:COG3852  223 -----KNIRIVRDYDPSLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVTLGGLRPRLYVRievidNGPG 297

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 446411665 353 ID---YSKFFERFYRedeshnNKKSGYGIGLSIVTSLVHLFKGSIDV 396
Cdd:COG3852  298 IPeeiLDRIFEPFFT------TKEKGTGLGLAIVQKIVEQHGGTIEV 338
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 312-405 1.67e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 52.00  E-value: 1.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 312 LVDNANKYCDPMGTVTVKLSRSSRlrRAKLEVSNTYKNGKDIDYSKFFERFYREDESHNNkkSGYGIGLSIVTSLVHLFK 391
Cdd:cd16923    8 LLSNAIKYSPENTRIYITSFLTDD--VVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNT--EGAGLGLSIAKAIIELHG 83

                         90
                 ....*....|....
gi 446411665 392 GSIDVNYKHDTITF 405
Cdd:cd16923   84 GSASAEYDDNHDLF 97
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 194-256 2.05e-08

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 50.67  E-value: 2.05e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446411665  194 KQRRFITNAGHELKTPLAIISANNELVEMMSGESEWTKSTN---DQIQRLTGLINGMVSLARFEEQ 256
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLEtilRSAERLLRLINDLLDLSRIEAG 66
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 193-252 2.99e-08

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 49.90  E-value: 2.99e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446411665 193 EKQRRFITNAGHELKTPLAIISANNELVEMMSGES----EWTKSTNDQIQRLTGLINGMVSLAR 252
Cdd:cd00082    2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDDeeqrEYLERIREEAERLLRLINDLLDLSR 65
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 301-394 3.25e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 51.31  E-value: 3.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 301 EEKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSRLRRakLEVSNTYKNGKDIDYSKFFERFYREDESHNNKKSGYGIGL 380
Cdd:cd16946    1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVR--LDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGL 78

                         90
                 ....*....|....
gi 446411665 381 SIVTSLVHLFKGSI 394
Cdd:cd16946   79 AICHNIALAHGGTI 92
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 194-256 4.20e-08

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 49.49  E-value: 4.20e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446411665   194 KQRRFITNAGHELKTPLAIISANNELVEMM---SGESEWTKSTNDQIQRLTGLINGMVSLARFEEQ 256
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLELLLDTelsEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 204-409 4.27e-08

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 54.80  E-value: 4.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 204 HELKTPLAIISANNELVEMMSGES-------EWTKSTNDQIQRLTGLINGMVSLARfeeQPDISMVDLDFSHITKDAAED 276
Cdd:COG4191  151 HEINNPLAAILGNAELLRRRLEDEpdpeelrEALERILEGAERAAEIVRSLRAFSR---RDEEEREPVDLNELIDEALEL 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 277 FKGPIIKDGKDFIMSIQPGIH-VKAEEKSLFELVTLLVDNAnkyCDPM-----GTVTVKLSRSSRlrRAKLEVSNtykNG 350
Cdd:COG4191  228 LRPRLKARGIEVELDLPPDLPpVLGDPGQLEQVLLNLLINA---IDAMeegegGRITISTRREGD--YVVISVRD---NG 299

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446411665 351 KDID---YSKFFERFY---REDEshnnkksGYGIGLSIVTSLVHLFKGSIDVNYKHD--TiTFVIYI 409
Cdd:COG4191  300 PGIPpevLERIFEPFFttkPVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGggT-TFTITL 358
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 308-396 4.90e-08

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 50.95  E-value: 4.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 308 LVTLLVDNANKYCDPMGTVTVKLSRSsRLRRAKLEVSNTYKNGKDIDYSKFFERFYREDESHNNKKSGYGIGLSIVTSLV 387
Cdd:cd16925    8 VVLNLLSNAFKFTPDGGRIRCILEKF-RLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIVKEFV 86


                 ....*....
gi 446411665 388 HLFKGSIDV 396
Cdd:cd16925   87 ELHGGTVTV 95
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 312-396 1.03e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 49.77  E-value: 1.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 312 LVDNANKYCDPMGTVTVKLSRSSRlrRAKLEVSNTyknGKDI-DY--SKFFERFYREDESHNNKKSGyGIGLSIVTSLVH 388
Cdd:cd16945   12 LLDNAIDFSPEGGLIALQLEADTE--GIELLVFDE---GSGIpDYalNRVFERFYSLPRPHSGQKST-GLGLAFVQEVAQ 85


                 ....*...
gi 446411665 389 LFKGSIDV 396
Cdd:cd16945   86 LHGGRITL 93
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
195-394 3.20e-07

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 52.24  E-value: 3.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 195 QRRFITNAGHELKTPLAIISANNELVEMMSGESEWTKSTNDQIQRLTGLINGMVSLARFEEQPDISMVDLDFSHITKDAA 274
Cdd:PRK09470 243 QQRLLSDISHELRTPLTRLQLATALLRRRQGESKELERIETEAQRLDSMINDLLVLSRNQQKNHLERETFKANSLWSEVL 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 275 EDFKGPIIKDGKDFIMSIQPG-IHVKAEEKSLFELVTLLVDNANKYCDpmGTVTVKLSrssrlrrakleVSNTY------ 347
Cdd:PRK09470 323 EDAKFEAEQMGKSLTVSAPPGpWPINGNPNALASALENIVRNALRYSH--TKIEVAFS-----------VDKDGltitvd 389

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 446411665 348 KNGKDI---DYSKFFERFYREDESHNNKKSGYGIGLSIVTSLVHLFKGSI 394
Cdd:PRK09470 390 DDGPGVpeeEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWV 439
envZ PRK09467
osmolarity sensor protein; Provisional
 202-397 9.88e-07

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 50.68  E-value: 9.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 202 AG--HELKTPLAIIsannELV-EMMSGESEWTK-STNDQIQRLTGLINGMVSLARFEEQPDISMVDLDfsHITKD--AAE 275
Cdd:PRK09467 234 AGvsHDLRTPLTRI----RLAtEMMSEEDGYLAeSINKDIEECNAIIEQFIDYLRTGQEMPMEMADLN--ALLGEviAAE 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 276 DfkgpiiKDGKDFIMSIQPG-IHVKAEEKSLFELVTLLVDNANKYcdpmGTVTVKLSRSSRLRRAKLEVSNtykNGKDI- 353
Cdd:PRK09467 308 S------GYEREIETALQPGpIEVPMNPIAIKRALANLVVNAARY----GNGWIKVSSGTEGKRAWFQVED---DGPGIp 374

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 446411665 354 --DYSKFFERFYREDESHNNkkSGYGIGLSIVTSLVHLFKGSIDVN 397
Cdd:PRK09467 375 peQLKHLFQPFTRGDSARGS--SGTGLGLAIVKRIVDQHNGKVELG 418
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 312-387 1.28e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 46.81  E-value: 1.28e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446411665 312 LVDNANKYCDPMGTVTVKLSRSSRlrRAKLEVSNTyknGKDID---YSKFFERFYREDESHNNKKSGYGIGLSIVTSLV 387
Cdd:cd16952    8 LVSNAVKYTPPSDTITVRWSQEES--GARLSVEDT---GPGIPpehIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVM 81
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
193-392 9.34e-06

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 47.27  E-value: 9.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 193 EKQRRFITNAGHELKTPLAIISANNELVEMmSGESEwTKSTNDQIQRLTGLINGMVSLARFEEqpdismvdlDFS---HI 269
Cdd:PRK10755 135 DQERLFTADVAHELRTPLAGIRLHLELLEK-QHHID-VAPLIARLDQMMHTVEQLLQLARAGQ---------SFSsghYQ 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 270 TKDAAEDfkgpIIKDGKD-------------FIMSIQPGIHVKAEEKSLFELVTLLVDNANKYCDPMGTVTVKLSrsSRL 336
Cdd:PRK10755 204 TVKLLED----VILPSQDelsemleqrqqtlLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLS--QED 277

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446411665 337 RRAKLEVSNtykNGKDIDYSK---FFERFYREDESHnnkkSGYGIGLSIVTSLVHLFKG 392
Cdd:PRK10755 278 GGAVLAVED---EGPGIDESKcgeLSKAFVRMDSRY----GGIGLGLSIVSRITQLHHG 329
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 312-396 4.42e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 42.48  E-value: 4.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 312 LVDNANKYCdPMGTVTVKLSRSSRLR---RAKLEVSNTyknGKDI---DYSKFFERFYREDESHNNKKSGYGIGLSIVTS 385
Cdd:cd16922    8 LLGNAIKFT-EEGEVTLRVSLEEEEEdgvQLRFSVEDT---GIGIpeeQQARLFEPFSQADSSTTRKYGGTGLGLAISKK 83

                         90
                 ....*....|.
gi 446411665 386 LVHLFKGSIDV 396
Cdd:cd16922   84 LVELMGGDISV 94
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 285-397 6.61e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 42.62  E-value: 6.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 285 GKDFIMSIQPGIHVKAEEKSLFELVTLLVDNANKYCDpmGTVTVKLSRSSrlRRAKLEVSNTYKNGKDIDYSKFFERFYR 364
Cdd:cd16954   18 GVSISLDISPELRFPGERNDLMELLGNLLDNACKWCL--EFVEVTARQTD--GGLHLIVDDDGPGVPESQRSKIFQRGQR 93

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446411665 365 EDESHnnkkSGYGIGLSIVTSLVHLFKGSIDVN 397
Cdd:cd16954   94 LDEQR----PGQGLGLAIAKEIVEQYGGELSLS 122
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 305-394 1.24e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 40.91  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 305 LFELVTLLVDNANKYCDPMGTVTVKLSRSSRLrrAKLEVSNTYKNGKDIDYSKFFERFYREDEShNNKKSGYGIGLSIVT 384
Cdd:cd16975    5 LSRALINIISNACQYAPEGGTVSISIYDEEEY--LYFEIWDNGHGFSEQDLKKALELFYRDDTS-RRSGGHYGMGLYIAK 81

                         90
                 ....*....|
gi 446411665 385 SLVHLFKGSI 394
Cdd:cd16975   82 NLVEKHGGSL 91
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 290-409 1.71e-04

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 43.30  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 290 MSIQPGIHVKAEEKSLFELVTL---LVDNA----NKYCDPMGTVTVKLSRSSRlrRAKLEVSNTYKNGKDIDYSKFFERF 362
Cdd:COG3290  264 LTIDIDSDLPDLPLSDTDLVTIlgnLLDNAieavEKLPEEERRVELSIRDDGD--ELVIEVEDSGPGIPEELLEKIFERG 341

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446411665 363 YREDESHnnkksGYGIGLSIVTSLVHLFKGSIDVNYKHDTIT-FVIYI 409
Cdd:COG3290  342 FSTKLGE-----GRGLGLALVKQIVEKYGGTIEVESEEGEGTvFTVRL 384
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 296-407 2.98e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 40.57  E-value: 2.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 296 IHVKAEEKSLFELVTLLVDNANKYCDPMGTVTVKLSRSSRlrRAKLEVSNTYKNGKDIDYSKFFERFYREDESHNNKKSG 375
Cdd:cd16947   12 IYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEK--HVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQG 89

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446411665 376 YGIGLSIVTSLVHLFKGSIDVNYK-HDTITFVI 407
Cdd:cd16947   90 NGLGLTITKRLAESMGGSIYVNSKpYEKTVFTV 122
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 305-396 3.24e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 39.71  E-value: 3.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 305 LFELVTLLVDNANKYCDPMGTVTVKLSRSSRlrRAKLEVSNtykNGKDIDYS---KFFERFYredeSHNNKKSGYGIGLS 381
Cdd:cd16943    4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVD--QVLIEVED---TGSGIDPEilgRIFDPFF----TTKPVGEGTGLGLS 74

                         90
                 ....*....|....*
gi 446411665 382 IVTSLVHLFKGSIDV 396
Cdd:cd16943   75 LSYRIIQKHGGTIRV 89
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 357-394 3.63e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 39.62  E-value: 3.63e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 446411665 357 KFFERFYREDESHNNKKSGYGIGLSIVTSLVHLFKGSI 394
Cdd:cd16949   49 QIFLPFYRVDSARDRESGGTGLGLAIAERAIEQHGGKI 86
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 312-396 4.10e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 39.34  E-value: 4.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 312 LVDNANKYCDPmgtvTVKLSRSSRLRRAKLEVSNtykNGKDI---DYSKFFERFYREDESHNNKKSGYGIGLSIVTSLVH 388
Cdd:cd16939    8 LLRNALRYAHR----TVRIALLVSGGRLTLIVED---DGPGIpaaARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVAL 80


                 ....*...
gi 446411665 389 LFKGSIDV 396
Cdd:cd16939   81 WHGGHVEC 88
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
197-396 4.46e-04

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 42.26  E-value: 4.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 197 RFITNAGHELKTPLAIISANNELVEMMSGESEWTKSTN---DQIQRLTGLINGMVSLARfEEQPDISMVDLDFshITKDA 273
Cdd:PRK11360 392 ELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSvvlREVDRLNKVIDQLLEFSR-PRESQWQPVSLNA--LVEEV 468

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 274 AEDFKGPIIKDGKDFIMSIQ---PGIHVKAEeksLFELVTL-LVDNANKYCDPMGTVTVKLSRSSRlRRAKLEVSNtykN 349
Cdd:PRK11360 469 LQLFQTAGVQARVDFETELDnelPPIWADPE---LLKQVLLnILINAVQAISARGKIRIRTWQYSD-GQVAVSIED---N 541

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 446411665 350 GKDID---YSKFFERFYredeshNNKKSGYGIGLSIVTSLVHLFKGSIDV 396
Cdd:PRK11360 542 GCGIDpelLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEV 585
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 308-394 3.60e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 36.66  E-value: 3.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 308 LVTLLVDNANKYcdpmGTVTVKLSRSSRLRRAKLEVSNtykNGKDIDYSK---FFERFYREDESHNNkkSGYGIGLSIVT 384
Cdd:cd16950    4 VLSNLVDNALRY----GGGWVEVSSDGEGNRTRIQVLD---NGPGIAPEEvdeLFQPFYRGDNARGT--SGTGLGLAIVQ 74

                         90
                 ....*....|
gi 446411665 385 SLVHLFKGSI 394
Cdd:cd16950   75 RISDAHGGSL 84
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 341-409 6.72e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 36.79  E-value: 6.72e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446411665 341 LEVSNTYKNGKDIDYSKFFErfyredeshNNKKSGYGIGLSIVTSLVHLFKGSIDVNYKHDTITFVIYI 409
Cdd:cd16935   75 ISIENSYEGELKKKNGLFLS---------TKKDKNHGIGLKSIREIVKKYNGNLSIEYENGIFTLSILL 134
ArsS_fam_HK NF038389
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ...
 198-407 9.03e-03

ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.


Pssm-ID: 468500 [Multi-domain]  Cd Length: 402  Bit Score: 37.90  E-value: 9.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 198 FITNAGHELKTPLA---IISannelvEMMsgESEWTKSTNDQI-QRLTGLINgmvSLARFEEQpdismvdldfshITKDA 273
Cdd:NF038389 209 FLRNIMHELKTPITkgrIVA------EML--EDEKQKERLISIfERLESLIN---EFAKIEQL------------TSKNY 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411665 274 AEDFK----GPIIKDGKDFIM--SIQPGIHVKAEEKSL---FELVTL----LVDNANKYcDPMGTVTVKLSRSsrlrraK 340
Cdd:NF038389 266 KLNKKeyrlSDIIDEAIDMLMidDSSVIIKVSLEDFKLnvdFELFSLaiknLIDNAIKY-SPDKKVTIEIKGD------K 338

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446411665 341 LEVSNtykNGKDIDY--SKFFERFYREdesHNNKKSGYGIGLSIVTSLVHLFKGSIDVNYKHDTITFVI 407
Cdd:NF038389 339 IEFKN---KGEPLEEplEYYFEPFFKG---NEKSKSGFGLGLYIVKNILKAHGFKLEYEYENGYNIFII 401
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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