riboflavin synthase catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil, the last step of riboflavin biosynthesis
Riboflavin synthase alpha chain [Coenzyme transport and metabolism]; Riboflavin synthase alpha ...
1-193
9.48e-107
Riboflavin synthase alpha chain [Coenzyme transport and metabolism]; Riboflavin synthase alpha chain is part of the Pathway/BioSystem: Riboflavin/FAD biosynthesis
Pssm-ID: 440076 Cd Length: 198 Bit Score: 305.04 E-value: 9.48e-107
Riboflavin synthase and similar proteins; Riboflavin synthase catalyzes the dismutation of two ...
1-185
1.05e-100
Riboflavin synthase and similar proteins; Riboflavin synthase catalyzes the dismutation of two molecules of 6,7-dimethyl-8-(1'-D-ribityl)-lumazine (DMRL) to yield riboflavin (vitamin B12) and 4-ribitylamino-5-amino-2,6-dihydroxypyrimidine (RAADP). Riboflavin synthase is a homotrimer and the catalysis does not require any cofactors. Active sites are located between pairs of monomers, but only one active site catalyzes a reaction, the other two sites are inactive. Humans do not produce riboflavin synthase, and thus it is a good target for antimicrobial agents. This family also include lumazine protein (LumP) from bioluminescent bacteria. LumP serves as an optical transponder in bioluminescence emission.
Pssm-ID: 293928 Cd Length: 185 Bit Score: 289.29 E-value: 1.05e-100
riboflavin synthase, alpha subunit; This protein family consists almost entirely of two ...
1-195
1.54e-73
riboflavin synthase, alpha subunit; This protein family consists almost entirely of two lumazine-binding domains, described in the family Lum_binding from Pfam. The model generates lower scores against other proteins that also have two lumazine-binding domains, including some involved in bioluminescence.The name ribE was selected, from among alternatives including ribB and ribC, to match the usage in EcoCyc. [Biosynthesis of cofactors, prosthetic groups, and carriers, Riboflavin, FMN, and FAD]
Pssm-ID: 272950 Cd Length: 200 Bit Score: 221.14 E-value: 1.54e-73
Lumazine binding domain; This domain binds to derivatives of lumazine in some proteins. Some ...
99-181
1.69e-31
Lumazine binding domain; This domain binds to derivatives of lumazine in some proteins. Some proteins have lost the residues involved in binding lumazine.
Pssm-ID: 459900 Cd Length: 83 Bit Score: 109.80 E-value: 1.69e-31
Riboflavin synthase alpha chain [Coenzyme transport and metabolism]; Riboflavin synthase alpha ...
1-193
9.48e-107
Riboflavin synthase alpha chain [Coenzyme transport and metabolism]; Riboflavin synthase alpha chain is part of the Pathway/BioSystem: Riboflavin/FAD biosynthesis
Pssm-ID: 440076 Cd Length: 198 Bit Score: 305.04 E-value: 9.48e-107
Riboflavin synthase and similar proteins; Riboflavin synthase catalyzes the dismutation of two ...
1-185
1.05e-100
Riboflavin synthase and similar proteins; Riboflavin synthase catalyzes the dismutation of two molecules of 6,7-dimethyl-8-(1'-D-ribityl)-lumazine (DMRL) to yield riboflavin (vitamin B12) and 4-ribitylamino-5-amino-2,6-dihydroxypyrimidine (RAADP). Riboflavin synthase is a homotrimer and the catalysis does not require any cofactors. Active sites are located between pairs of monomers, but only one active site catalyzes a reaction, the other two sites are inactive. Humans do not produce riboflavin synthase, and thus it is a good target for antimicrobial agents. This family also include lumazine protein (LumP) from bioluminescent bacteria. LumP serves as an optical transponder in bioluminescence emission.
Pssm-ID: 293928 Cd Length: 185 Bit Score: 289.29 E-value: 1.05e-100
riboflavin synthase, alpha subunit; This protein family consists almost entirely of two ...
1-195
1.54e-73
riboflavin synthase, alpha subunit; This protein family consists almost entirely of two lumazine-binding domains, described in the family Lum_binding from Pfam. The model generates lower scores against other proteins that also have two lumazine-binding domains, including some involved in bioluminescence.The name ribE was selected, from among alternatives including ribB and ribC, to match the usage in EcoCyc. [Biosynthesis of cofactors, prosthetic groups, and carriers, Riboflavin, FMN, and FAD]
Pssm-ID: 272950 Cd Length: 200 Bit Score: 221.14 E-value: 1.54e-73
Lumazine binding domain; This domain binds to derivatives of lumazine in some proteins. Some ...
99-181
1.69e-31
Lumazine binding domain; This domain binds to derivatives of lumazine in some proteins. Some proteins have lost the residues involved in binding lumazine.
Pssm-ID: 459900 Cd Length: 83 Bit Score: 109.80 E-value: 1.69e-31
Lumazine binding domain; This domain binds to derivatives of lumazine in some proteins. Some ...
3-85
1.77e-31
Lumazine binding domain; This domain binds to derivatives of lumazine in some proteins. Some proteins have lost the residues involved in binding lumazine.
Pssm-ID: 459900 Cd Length: 83 Bit Score: 109.80 E-value: 1.77e-31
lumazine protein; Lumazine protein (LumP) is involved in the bioluminescence of certain marine ...
1-181
6.42e-27
lumazine protein; Lumazine protein (LumP) is involved in the bioluminescence of certain marine bacteria. It serves as an optical transponder in bioluminescence emission. The intense fluorescence of LumP is caused by non-covalently bound 6,7- dimethyl-8-ribityllumazine. Though its amino acid sequence is very similar to riboflavin synthase it functions as a monomer, unlike the riboflavin synthases from eubacteria, yeasts and plants which act as trimers.
Pssm-ID: 293929 Cd Length: 186 Bit Score: 101.34 E-value: 6.42e-27
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
Click on the triangle to view details about the feature, including a multiple sequence alignment
of your query sequence and the protein sequences used to curate the domain model,
where hash marks (#) above the aligned sequences show the location of the conserved feature residues.
The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions.
Click on the triangle for interactive 3D structure viewing options.
Functional characterization of the conserved domain architecture found on the query.
Click here to see more details.
This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
(labeled illustration) or all hits
(labeled illustration).
Domains are color coded according to superfamilies
to which they have been assigned. Hits with scores that pass a domain-specific threshold
(specific hits) are drawn in bright colors.
Others (non-specific hits) and
superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features),
they are mapped to the query sequence and indicated through sets of triangles
with the same color and shade of the domain or superfamily that provides the annotation. Mouse over the colored bars or triangles to see descriptions of the domains and features.
click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
mapped to the query sequence.
Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the
advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
(CDART).
Modify your query to search against a different database and/or use advanced search options
