|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
99-462 |
4.28e-95 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 292.23 E-value: 4.28e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 99 SLISEGDRQTLLDGKTVTKIGYEEHFDRNIMGVVIPVLENKKLVGIVYSYIPLKSIKDLIYDMGLILAPLAIAMILITIW 178
Cdd:COG5002 25 LLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLIL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 179 VGRKIIIAITKPLSQMERVANHLATGDFSERITVSSEDEIGRLGKAFNKMANSLETEDVKRKEFLANVSHELRTPLSYIK 258
Cdd:COG5002 105 LLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 259 GYSEAILDGVAKGP-QQEKVTQLIHKEAGRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKEIHI 337
Cdd:COG5002 185 GYLELLLDGAADDPeERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIEL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 338 STNLNPE-VIVMIDEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKAR 416
Cdd:COG5002 265 ELDLPEDpLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSR 344
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 446416941 417 SRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKLNVQDE 462
Cdd:COG5002 345 SRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
224-457 |
4.52e-79 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 245.59 E-value: 4.52e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 224 AFNKMANSLETEDVKRKEFLANVSHELRTPLSYIKGYSEAILDGVAKGP-QQEKVTQLIHKEAGRMQRLVHDLLDLAQLE 302
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPeERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 303 GEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKEIHISTNLNPE-VIVMIDEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQ 381
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446416941 382 IDDYCELKIKDTGIGIDIEHLENLGERFYRVDkaRSRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
106-457 |
1.17e-77 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 253.14 E-value: 1.17e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 106 RQTLLDGKTVTKIGYEEHFDRNIMGVVIPVL-ENKKLVGIVYSYIPLKSIKDLIYDMGLILAPLAIAMILITIWVGrkII 184
Cdd:NF033092 119 KRALLGGKDNEKILIDPEDNNRVYVLATPIKsSNGEVVGAIYIEASMESVYDQMNNINLIFATGTLIALVITAVLG--IL 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 185 IA--ITKPLSQMERVANHLATGDFSERITVSSEDEIGRLGKAFNKMANSLE----------------------------- 233
Cdd:NF033092 197 LArtITRPIKEMRKQALAMAKGDFSRKVKVYGNDEIGQLAEAFNNLTKRLQeaqatteserrkldsvlshmtdgviatdr 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 --------------------------------------------------------------------------------
Cdd:NF033092 277 rgrvilindpalemlnvsretvlgqsildvlgleeeytlrdlleeqdsllldfsteeeplilranfsviqresgfingli 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 234 ------TE----DVKRKEFLANVSHELRTPLSYIKGYSEAILDGVAK----GPQQEKVTQlihKEAGRMQRLVHDLLDLA 299
Cdd:NF033092 357 avlhdvTEqekiEQERREFVANVSHELRTPLTTMRSYLEALADGAWKdpelAPRFLGVTQ---NETERMIRLVNDLLQLS 433
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 300 QLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKEIHISTNLNPEVI-VMIDEDRMQQVLHNVLDNAIRYTNQKGNIVIT 378
Cdd:NF033092 434 RMDSKDYKLNKEWVNFNEFFNYIIDRFEMILKNKNITFKREFPKRDLwVEIDTDKITQVLDNIISNAIKYSPEGGTITFR 513
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446416941 379 LEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:NF033092 514 LLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTL 592
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
157-457 |
3.35e-77 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 244.05 E-value: 3.35e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 157 LIYDMGLILAPLAIAMILITIWVGRKIIIAITKPLSQMERVANHLATGDFSERITVSSEDEIGRLGKAFNKMANSLETED 236
Cdd:COG0642 28 LLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEAN 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 237 VKRKEFLANVSHELRTPLSYIKGYSEAILDGVAkgPQQEKVTQLIHKEAGRMQRLVHDLLDLAQLEGEHFPLKKQPIVFS 316
Cdd:COG0642 108 EAKSRFLANVSHELRTPLTAIRGYLELLLEELD--EEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 317 QLIEDVLDTYEIKFIEKEIHISTNLNPEVI-VMIDEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGI 395
Cdd:COG0642 186 ELLEEVVELFRPLAEEKGIELELDLPDDLPtVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGP 265
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446416941 396 GIDIEHLENLGERFYRVDkaRSRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:COG0642 266 GIPPEDLERIFEPFFRTD--PSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
239-452 |
2.03e-74 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 237.11 E-value: 2.03e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 239 RKEFLANVSHELRTPLSYIKGYSEAILDGVAKGPQ-QEKVTQLIHKEAGRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQ 317
Cdd:TIGR02966 114 RRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEeWNRALEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDEPVDMPA 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 318 LIEDVLDTYEIKFIEKEIHISTNLNPEVIVMIDEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGI 397
Cdd:TIGR02966 194 LLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGI 273
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 446416941 398 DIEHLENLGERFYRVDKARSRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTT 452
Cdd:TIGR02966 274 APEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIESELGKGST 328
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
200-439 |
5.20e-65 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 216.81 E-value: 5.20e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 200 HLATGDFSERITVSSEDEIGRLGKAFNKMANSLETEDVKRKEFLANVSHELRTPLSYIKGYSEAILDGVAKgPQQEKVTQ 279
Cdd:PRK10549 201 KLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGELEAIQDGVRK-FTPESVAS 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 280 LiHKEAGRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKEIHISTNLNPEVIVMIDEDRMQQVLH 359
Cdd:PRK10549 280 L-QAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFN 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 360 NVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVKQIVHIHGG 439
Cdd:PRK10549 359 NLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNG 438
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
134-457 |
4.30e-61 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 206.22 E-value: 4.30e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 134 PVLENKKLVGivysYIPLKSIKDLI------YDMG------LILAPLAIAMILITIWVGRkiiiAITKPLSQMERVANHL 201
Cdd:NF012163 131 PILVNGQEVG----ALGASPVERLTrntdinFDSQqkraswLIVALALLLAALAAFLLAR----GLLAPVKRLVEATHRL 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 202 ATGDFSERITVSSEDEIGRLGKAFNKMANSLETEDVKRKEFLANVSHELRTPLSYIKGYSEAILDGVAKGpQQEKVTQLi 281
Cdd:NF012163 203 AAGDYTTRVTPTSNDELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRAELEAIQDGIRKF-TPESLDSL- 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 282 HKEAGRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKEIHISTNLNPEVIVMIDEDRMQQVLHNV 361
Cdd:NF012163 281 QAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVEGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNL 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 362 LDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVKQIVHIHGGQW 441
Cdd:NF012163 361 LENSLRYTDSGGSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTL 440
|
330
....*....|....*.
gi 446416941 442 KIESEKDKGTTVIIKL 457
Cdd:NF012163 441 HAAHSPLGGLRIVVTL 456
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
162-463 |
6.88e-59 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 199.42 E-value: 6.88e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 162 GLILAPLAIAMILITIWVGRKIIIAITKPLSQMERVANHLATGDFSERITVSSEDEIGRLGKAFNKMANSLET---EDVK 238
Cdd:COG5000 8 LLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEqreELEE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 239 RKEFLANV------------------------------------------------------------------------ 246
Cdd:COG5000 88 RRRYLETIlenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeeieltrdgr 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 247 -----------------------------------------SHELRTPLSYIKGYSEAILDGVAKGPQQ-----EKVTQL 280
Cdd:COG5000 168 rtllvrasplrddgyvivfdditellraerlaawgelarriAHEIKNPLTPIQLSAERLRRKLADKLEEdredlERALDT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 281 IHKEAGRMQRLVHDLLDLAQLEgehfPLKKQPIVFSQLIEDVLDTYEIKFIEKEIHISTNLNPEV-IVMIDEDRMQQVLH 359
Cdd:COG5000 248 IIRQVDRLKRIVDEFLDFARLP----EPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLpEVLADRDQLEQVLI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 360 NVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYrvdkarSRQHGGTGLGLAIVKQIVHIHGG 439
Cdd:COG5000 324 NLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGG 397
|
410 420
....*....|....*....|....
gi 446416941 440 QWKIESEKDKGTTVIIKLNVQDEG 463
Cdd:COG5000 398 TIELESRPGGGTTFTIRLPLAEEA 421
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
73-457 |
1.33e-52 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 184.84 E-value: 1.33e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 73 ISSSDVIFVSNPRDLSACLP---FDVHHHSLISEGDRQTLLDGKT---VTKIGYEEHFDRNIMGVVI------PVLENKK 140
Cdd:NF040691 90 QGAFDVVLLVPGDDPSGLGPrasGSVGLVSQIPEELREAVAGGQVaqqYQSVALPSGDGSSAPALVVgtpvtlPVAGNYE 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 141 LvgivYSYIPLKSIKDLIYDMG--LILAPLAIAMIL--ITIWVGRKIiiaiTKPLSQMERVANHLATGDFSERITVSSED 216
Cdd:NF040691 170 L----YLLFPLEDEQSTLALVRgtLLLGGLALVVLLglIAWLVTRQV----VAPVRSAARTAERFAAGDLSERMPVKGED 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 217 EIGRLGKAFNKMANSL-----ETEDVKR--KEFLANVSHELRTPLSYIKGYSEAILDGVAK-GPQQEKVTQLIHKEAGRM 288
Cdd:NF040691 242 DLARLARSFNQMADSLqrqirQLEELSRlqQRFVSDVSHELRTPLTTIRMAADVIHDSRDDfDPATARSAELLHTELDRF 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 289 QRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKEIHISTNLnPE--VIVMIDEDRMQQVLHNVLDNAI 366
Cdd:NF040691 322 ESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDA-PGtpVVAEVDPRRVERVLRNLVVNAI 400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 367 RYTNQKgNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVKQIVHIHGGQWKIESE 446
Cdd:NF040691 401 EHGEGK-PVVVTVAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGR 479
|
410
....*....|.
gi 446416941 447 KDKGTTVIIKL 457
Cdd:NF040691 480 PGQGSQFRLTL 490
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
239-452 |
3.02e-49 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 174.04 E-value: 3.02e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 239 RKEFLANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEAGRMQRLVHDLLDLAQLEGehfplkkQPIVFSQL 318
Cdd:PRK11006 204 RRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEA-------APTIDLNE 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 319 IEDVLDTYEIkfIEKEI--------HISTNLNPEVIVMIDEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKI 390
Cdd:PRK11006 277 KVDVPMMLRV--LEREAqtlsqgkhTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSV 354
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446416941 391 KDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTT 452
Cdd:PRK11006 355 EDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTR 416
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
241-462 |
3.88e-46 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 167.27 E-value: 3.88e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 241 EFLANVSHELRTPLSYIKGYSEAILD--GVAKGPQQEKVTQLIHKEAGRMQRLVHDLLDLAQLEGEhfPLKKQPIVFSQL 318
Cdd:COG4251 284 QFAYVASHDLREPLRKISGFSQLLEEdyGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQ--ELEFEPVDLNEL 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 319 IEDVLDTYEIKFIEKEIHISTNLNPEVivMIDEDRMQQVLHNVLDNAIRYT--NQKGNIVITLEQIDDYCELKIKDTGIG 396
Cdd:COG4251 362 LEEVLEDLEPRIEERGAEIEVGPLPTV--RGDPTLLRQVFQNLISNAIKYSrpGEPPRIEIGAEREGGEWVFSVRDNGIG 439
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446416941 397 IDIEHLENLGERFYRVDkaRSRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKLNVQDE 462
Cdd:COG4251 440 IDPEYAEKIFEIFQRLH--SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAPA 503
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
174-457 |
6.02e-46 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 163.24 E-value: 6.02e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 174 LITIWVGRKIIIAITKPLSQMERVANHLATGDFSERI--TVSSEDEIGRLGKAFNKMANSLETEdVKRKEFL-ANVSHEL 250
Cdd:NF012226 71 VISLIIGMKLAQRFIVPINFLADAAKKISQGDLSARAedSQIHSAEISELMHNFNDMAQKLESS-VKNAQVWnAAIAHEL 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 251 RTPLSYIKGYSEAILDGVAKgPQQEKVTQLIHKEAGrMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKF 330
Cdd:NF012226 150 RTPITILQGRLQGILDGVFE-PDPALFKSLLNQVEG-LSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEKVLKMFEDRL 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 331 IEKEIHISTNLnPEVIVMIDEDRMQQVLHNVLDNAIRYTNQkGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFY 410
Cdd:NF012226 228 EQAQLTIVLNL-TATPVFCDRRRIEQVLIALIDNAIRYANA-GKLKISSSVIQDDWILQIEDEGPGIAEEYQQDLFNPFF 305
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 446416941 411 RVDKARSRQHGGTGLGLAIVKQIVHIHGGQwkIESEKDKGTTV-IIKL 457
Cdd:NF012226 306 RLEQSRNKEFGGTGLGLAVVHAIVIAHKGS--IEYSNSQGNSVfTIKL 351
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
244-457 |
2.21e-45 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 161.89 E-value: 2.21e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 244 ANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQL---IHKEAGRMQRLVHDLLDLAQLEgehfPLKKQPIVFSQLIE 320
Cdd:COG4191 147 AGIAHEINNPLAAILGNAELLRRRLEDEPDPEELREAlerILEGAERAAEIVRSLRAFSRRD----EEEREPVDLNELID 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 321 DVLDTYEIKFIEKEIHISTNLNPEVI-VMIDEDRMQQVLHNVLDNAIR--YTNQKGNIVITLEQIDDYCELKIKDTGIGI 397
Cdd:COG4191 223 EALELLRPRLKARGIEVELDLPPDLPpVLGDPGQLEQVLLNLLINAIDamEEGEGGRITISTRREGDYVVISVRDNGPGI 302
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446416941 398 DIEHLENLGERFY---RVDKarsrqhgGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:COG4191 303 PPEVLERIFEPFFttkPVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
168-445 |
4.00e-45 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 163.33 E-value: 4.00e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 168 LAIAMILITIWVGRKIIIAITKPLSQMERVANHLATGDFSERITVS-SEDEIGRLGKAFNKMANSLETEDVKRKEFLANV 246
Cdd:TIGR01386 169 IAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSrAPAELRELAQSFNAMLGRLEDAFQRLSQFSADL 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 247 SHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEAGRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTY 326
Cdd:TIGR01386 249 AHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADNGQLALERVRLDLAAELAKVAEYF 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 327 EIKFIEKEIHISTNLNPEVIVmiDEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLG 406
Cdd:TIGR01386 329 EPLAEERGVRIRVEGEGLVRG--DPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLF 406
|
250 260 270
....*....|....*....|....*....|....*....
gi 446416941 407 ERFYRVDKARSRQHGGTGLGLAIVKQIVHIHGGQWKIES 445
Cdd:TIGR01386 407 DRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAES 445
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
128-459 |
1.52e-43 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 159.62 E-value: 1.52e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 128 IMGVVIPVLENKKLVGIVYSYIPLKSI---------KDLIYDMGLILAPLAIAmILITIWvgrkiiiaITKPLSQMERVA 198
Cdd:PRK11100 147 VMYVAAPIRDGGRIIGVLSVGKPNSSMapfikrserRILWAGALLLGIALLIG-AGVVWW--------LNRSIRRLTRYA 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 199 NHLATGdfsERITV--SSEDEIGRLGKAFNKMANSLETedvkrKEFLANV----SHELRTPLSYIKGYSEaILDGVAKGP 272
Cdd:PRK11100 218 DAVTEG---KPVPLpkLGSSELRELAQALESMRVKLEG-----KAYVEQYvqtlTHELKSPLAAIRGAAE-LLQEDPPPE 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 273 QQEKVTQLIHKEAGRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKEIHIsTNLNPEVIVMIDED 352
Cdd:PRK11100 289 DRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITL-RLRPDDARVLGDPF 367
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 353 RMQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFY---RVDKARSrqhgGTGLGLAI 429
Cdd:PRK11100 368 LLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK----STGLGLAF 443
|
330 340 350
....*....|....*....|....*....|
gi 446416941 430 VKQIVHIHGGQWKIESEKDKGTTVIIKLNV 459
Cdd:PRK11100 444 VREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
189-445 |
2.51e-43 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 157.84 E-value: 2.51e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 189 KPLSQMERVANHLATGDFSERITVSSEDEIGRLGKAFNKMANSLETEDVKRKEFLANVSHELRTPLSYIKgYSEAILDGV 268
Cdd:PRK10604 162 QDMLKLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLR-YRLEMSDNL 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 269 AKGPQQEkvtqlIHKEAGRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKEIHISTNLNPEVIVm 348
Cdd:PRK10604 241 SAAESQA-----LNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGA- 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 349 IDEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQiDDYCeLKIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLA 428
Cdd:PRK10604 315 LDMRLMERVLDNLLNNALRYAHSRVRVSLLLDG-NQAC-LIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLA 392
|
250
....*....|....*..
gi 446416941 429 IVKQIVHIHGGQWKIES 445
Cdd:PRK10604 393 IVHSIALAMGGSVNCDE 409
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
233-457 |
4.88e-39 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 147.43 E-value: 4.88e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 233 ETEDVKRK--------EFLANVSHELRTPLSYIKGYSEAILDGVAKgpQQEKVTQLIHKEAGRMQRLVHDLLDLAQLEGE 304
Cdd:COG5809 256 KLEELLRKseklsvvgELAAGIAHEIRNPLTSLKGFIQLLKDTIDE--EQKTYLDIMLSELDRIESIISEFLVLAKPQAI 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 305 HFplkkQPIVFSQLIEDVLDTYEIKFIEKEIHISTNLN-PEVIVMIDEDRMQQVLHNVLDNAIRYTNQKGNIVI-TLEQI 382
Cdd:COG5809 334 KY----EPKDLNTLIEEVIPLLQPQALLKNVQIELELEdDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIeTKAED 409
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446416941 383 DDYCELKIKDTGIGIDIEHLENLGERFYrvdkarSRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:COG5809 410 DDKVVISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
240-457 |
1.26e-38 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 143.45 E-value: 1.26e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 240 KEFLANVSHELRTPLSYIKGYSEAILDGVAKGPQQEkVTQLIHKEAGRMQRLVHDLLDLAQLEgehfPLKKQPIVFSQLI 319
Cdd:COG3852 136 GELAAGLAHEIRNPLTGIRGAAQLLERELPDDELRE-YTQLIIEEADRLNNLVDRLLSFSRPR----PPEREPVNLHEVL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 320 EDVLDTYEIKFiEKEIHISTNLNPEVI-VMIDEDRMQQVLHNVLDNAIRYTNQKGNIVITLE----------QIDDYCEL 388
Cdd:COG3852 211 ERVLELLRAEA-PKNIRIVRDYDPSLPeVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRverqvtlgglRPRLYVRI 289
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446416941 389 KIKDTGIGIDIEHLENLGERFYrvdkarSRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:COG3852 290 EVIDNGPGIPEEILDRIFEPFF------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
349-457 |
7.78e-38 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 133.54 E-value: 7.78e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 349 IDEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKaRSRQHGGTGLGLA 428
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100
....*....|....*....|....*....
gi 446416941 429 IVKQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITL 108
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
354-457 |
7.56e-37 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 130.80 E-value: 7.56e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 354 MQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKarSRQHGGTGLGLAIVKQI 433
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 446416941 434 VHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
163-457 |
2.56e-36 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 139.91 E-value: 2.56e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 163 LILAPLAIAMILITIwvgrkIIIAITK---PLSQMERVANHLATGDFSERI---TVSSEDEigRLGKAFNKMANSLETED 236
Cdd:PRK09835 187 LIMTASVISLLIVFI-----VLLAVHKghaPIRSVSRQIQNITSKDLDVRLdpqTVPIELE--QLVLSFNHMIERIEDVF 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 237 VKRKEFLANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEAGRMQRLVHDLLDLAQLEGEHFPLKKQPIVFS 316
Cdd:PRK09835 260 TRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLA 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 317 QLIEDVLDTYEIKFIEKEIHISTNLNPeVIVMIDEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIG 396
Cdd:PRK09835 340 DEVGKVFDFFEAWAEERGVELRFVGDP-CQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTP 418
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446416941 397 IDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDkGTTVIIKL 457
Cdd:PRK09835 419 IAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDAR-GTRFVISL 478
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
235-462 |
1.44e-34 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 134.53 E-value: 1.44e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 235 EDVKRKEFL-------ANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEAGRMQRLVHDLLDLAQlegehfP 307
Cdd:PRK10364 226 DEMKRKEKLvalghlaAGVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVK------P 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 308 --LKKQPIVFSQLIEDVLDTYEIKFIEKEIHISTNLNPEV-IVMIDEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQIDD 384
Cdd:PRK10364 300 thLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGA 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 385 YCELKIKDTGIGIDIEHLENLgerF--YRVDKARsrqhgGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKLNVQDE 462
Cdd:PRK10364 380 GVKISVTDSGKGIAADQLEAI---FtpYFTTKAE-----GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNIT 451
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
241-465 |
1.65e-34 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 136.25 E-value: 1.65e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 241 EFLANVSHELRTPLSYIKGYSEAILDGvAKGPQQEKVTQLIHKEAGRMQRLVHDLLDLAQLEgehfPLKKQPIVFSQLIE 320
Cdd:PRK11360 392 ELVAGVAHEIRNPLTAIRGYVQIWRQQ-TSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPR----ESQWQPVSLNALVE 466
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 321 DVLDTYEIKFIEKEIHISTNLNPEV-IVMIDEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQI-DDYCELKIKDTGIGID 398
Cdd:PRK11360 467 EVLQLFQTAGVQARVDFETELDNELpPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYsDGQVAVSIEDNGCGID 546
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446416941 399 IEHLENLGERFYRVdKARsrqhgGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKLNVQDEGSM 465
Cdd:PRK11360 547 PELLKKIFDPFFTT-KAK-----GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGNQ 607
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
149-461 |
9.42e-33 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 132.07 E-value: 9.42e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 149 IPLKSIKDLIYDMGLILAPLAI----AMILITIWVGRkiiIAITKPLSQMERVANHLATGDFSERITVSSEDEIGRLGKA 224
Cdd:PRK15347 282 YPRRNLANEALKPALQQLPFALlilvLLTSVLFLLLR---RYLAKPLWRFVDIINKTGPAALEPRLPENRLDELGSIAKA 358
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 225 FNKMANSLETE-DV-----------------------KRK-EFLANVSHELRTPLSYIKGYSEaILDGVAKGPQQEKVTQ 279
Cdd:PRK15347 359 YNQLLDTLNEQyDTlenkvaertqalaeakqraeqanKRKsEHLTTISHEIRTPLNGVLGALE-LLQNTPLTAEQMDLAD 437
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 280 LIHKEAGRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKEIHISTNLNPEV--IVMIDEDRMQQV 357
Cdd:PRK15347 438 TARQCTLSLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVplYLHLDSLRLRQI 517
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 358 LHNVLDNAIRYTnQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKarsrQHGGTGLGLAIVKQIVHIH 437
Cdd:PRK15347 518 LVNLLGNAVKFT-ETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMM 592
|
330 340
....*....|....*....|....
gi 446416941 438 GGQWKIESEKDKGTTVIIKLNVQD 461
Cdd:PRK15347 593 GGELTLFSTPGVGSCFSLVLPLNE 616
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
350-457 |
5.26e-32 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 117.85 E-value: 5.26e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 350 DEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQiDDYCELKIKDTGIGIDIEHLENLGERFYRVDKarsRQHGGTGLGLAI 429
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSI 77
|
90 100
....*....|....*....|....*...
gi 446416941 430 VKQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTL 105
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
215-450 |
2.51e-30 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 121.21 E-value: 2.51e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 215 EDEIGRLGKAFNKMANSLETEDvkrkEFLANVSHELRTPLSyikGYSEAI--LDGVAKGPQQEKVTQLI---HKEAGR-- 287
Cdd:PRK09303 131 SDELFVLRQENETLLEQLKFKD----RVLAMLAHDLRTPLT---AASLALetLELGQIDEDTELKPALIeqlQDQARRql 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 288 --MQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKEIHISTNLNPEV-IVMIDEDRMQQVLHNVLDN 364
Cdd:PRK09303 204 eeIERLITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLpSVYADQERIRQVLLNLLDN 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 365 AIRYTNQKGNIVIT-LEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDkaRSRQHGGTGLGLAIVKQIVHIHGGQWKI 443
Cdd:PRK09303 284 AIKYTPEGGTITLSmLHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWV 361
|
....*..
gi 446416941 444 ESEKDKG 450
Cdd:PRK09303 362 DSEPGQG 368
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
354-459 |
2.95e-30 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 113.36 E-value: 2.95e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 354 MQQVLHNVLDNAIRYTNqKGNIVITL---EQIDDYCELK--IKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLA 428
Cdd:cd16922 1 LRQILLNLLGNAIKFTE-EGEVTLRVsleEEEEDGVQLRfsVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|.
gi 446416941 429 IVKQIVHIHGGQWKIESEKDKGTTVIIKLNV 459
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
242-452 |
4.11e-30 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 124.12 E-value: 4.11e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 242 FLANVSHELRTPLSYIKGYSEaILDGVAKGPQQEKVTQLIHKEAGRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIED 321
Cdd:TIGR02956 467 FLATMSHEIRTPLNGILGTLE-LLGDTGLTSQQQQYLQVINRSGESLLDILNDILDYSKIEAGHLSISPRPFDLNALLDD 545
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 322 VLDTYEIKFIEKEIHISTNLN---PEVIVmIDEDRMQQVLHNVLDNAIRYTNQkGNIVITLEQIDDYCEL-KIKDTGIGI 397
Cdd:TIGR02956 546 VHHLMVSRAQLKGIQLRLNIPeqlPNWWQ-GDGPRIRQVLINLVGNAIKFTDR-GSVVLRVSLNDDSSLLfEVEDTGCGI 623
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 446416941 398 DIEHLENLGERFYRVDKARSRqhGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTT 452
Cdd:TIGR02956 624 AEEEQATLFDAFTQADGRRRS--GGTGLGLAISQRLVEAMDGELGVESELGVGSC 676
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
244-457 |
5.87e-30 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 121.76 E-value: 5.87e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 244 ANVSHELRTPLSYIKGYSEAILDGVAKgpqQEKVTQLIHKEAGRMQRLVHDLLDLAQLEgehfPLKKQPIVFSQLIEDVL 323
Cdd:COG5805 292 AGIAHEIRNPLTSIKGFLQLLQPGIED---KEEYFDIMLSELDRIESIISEFLALAKPQ----AVNKEKENINELIQDVV 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 324 DTYEIKFIEKEIHISTNLNPEVI-VMIDEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHL 402
Cdd:COG5805 365 TLLETEAILHNIQIRLELLDEDPfIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERL 444
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 446416941 403 ENLGERFYrvdkarSRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:COG5805 445 KKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITL 493
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
241-457 |
7.48e-30 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 120.36 E-value: 7.48e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 241 EFLANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEAGRMQRLVHDLLDLAQLEGEhfplKKQPIVFSQLIE 320
Cdd:COG5806 203 ELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAKPQPE----KLEKIDVSEELE 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 321 DVLDTYEIKFIEKEIHISTNLNPEVIVMIDEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIE 400
Cdd:COG5806 279 HVIDVLSPYANMNNVEIQTELEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKE 358
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 446416941 401 HLENLGERFYrvdkarSRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:COG5806 359 QLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITL 409
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
241-452 |
1.93e-29 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 122.27 E-value: 1.93e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 241 EFLANVSHELRTPLSYIKGYSEAILdgvaKGP----QQEKVtQLIHKEAGRMQRLVHDLLDLAQLEGEHFPLKKQPIVFS 316
Cdd:PRK11107 295 EFLANMSHELRTPLNGVIGFTRQTL----KTPltptQRDYL-QTIERSANNLLAIINDILDFSKLEAGKLVLENIPFSLR 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 317 QLIEDVldtyeIKFI-----EKEIHISTNLNPEV--IVMIDEDRMQQVLHNVLDNAIRYTnQKGNIVITLE---QIDDYC 386
Cdd:PRK11107 370 ETLDEV-----VTLLahsahEKGLELTLNIDPDVpdNVIGDPLRLQQIITNLVGNAIKFT-ESGNIDILVElraLSNTKV 443
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446416941 387 ELK--IKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTT 452
Cdd:PRK11107 444 QLEvqIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGST 511
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
168-457 |
5.82e-29 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 118.50 E-value: 5.82e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 168 LAIAMILIT----IWVGRkiiiAITKPLSQMERVANHLATGDFseRITVSSED---EIGRLGKAFNKMANSLETEDVKRK 240
Cdd:PRK09470 171 LLLVTMLVStpllLWLAW----SLAKPARKLKNAADEVAQGNL--RQHPELETgpqEFRQAGASFNQMVTALERMMTSQQ 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 241 EFLANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKvtqlIHKEAGRMQRLVHDLLDLA------QLEGEHFPLkkqpiv 314
Cdd:PRK09470 245 RLLSDISHELRTPLTRLQLATALLRRRQGESKELER----IETEAQRLDSMINDLLVLSrnqqknHLERETFKA------ 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 315 fSQLIEDVLD--TYEIKFIEKEIHISTNLNPEVIVMiDEDRMQQVLHNVLDNAIRYTNQKgnIVITLEQIDDYCELKIKD 392
Cdd:PRK09470 315 -NSLWSEVLEdaKFEAEQMGKSLTVSAPPGPWPING-NPNALASALENIVRNALRYSHTK--IEVAFSVDKDGLTITVDD 390
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446416941 393 TGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:PRK09470 391 DGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWL 455
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-439 |
7.01e-29 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 109.47 E-value: 7.01e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 350 DEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAI 429
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90
....*....|
gi 446416941 430 VKQIVHIHGG 439
Cdd:cd16946 81 CHNIALAHGG 90
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-452 |
3.32e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 104.98 E-value: 3.32e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 360 NVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVKQIVHIHGG 439
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86
|
90
....*....|...
gi 446416941 440 QWKIESEKDKGTT 452
Cdd:cd16952 87 RLLIASELGKGSR 99
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
197-450 |
6.41e-27 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 114.36 E-value: 6.41e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 197 VANHLatgdfsERITVSSEDEIGRLGKAFNKMANSLetedvkrkefLANVSHELRTPLSYIKGYSEAI-LDGVAKG-PQQ 274
Cdd:PRK10490 638 IANAL------ERLTLTASEEQARLASEREQLRNAL----------LAALSHDLRTPLTVLFGQAEILtLDLASEGsPHA 701
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 275 EKVTQLihkeagRMQ-----RLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKEIHISTnlnPEVIVMI 349
Cdd:PRK10490 702 RQASEI------RQQvlnttRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSL---PEPLTLI 772
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 350 DEDR--MQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARSRQhgGTGLGL 427
Cdd:PRK10490 773 HVDGplFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIP--GVGLGL 850
|
250 260
....*....|....*....|...
gi 446416941 428 AIVKQIVHIHGGQWKIESEKDKG 450
Cdd:PRK10490 851 AICRAIVEVHGGTIWAENRPEGG 873
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
165-452 |
2.17e-26 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 109.67 E-value: 2.17e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 165 LAPlAIAMILITIWVGRKIIIAITKPLSQM-----ERVANHLATGDFSeritvSSEDEIGRLGKAFN----KMANSLETE 235
Cdd:PRK10755 64 LVP-SLVMVSLTLLICFQAVRWITRPLAELqkeleARTADNLTPIAIH-----SSTLEIEAVTSALNqlvsRLTSTLDQE 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 236 dvkrKEFLANVSHELRTPLSYIKGYseaiLDGVAK-GPQQekVTQLIhKEAGRMQRLVHDLLDLAQLE-----GEHFPLK 309
Cdd:PRK10755 138 ----RLFTADVAHELRTPLAGIRLH----LELLEKqHHID--VAPLI-ARLDQMMHTVEQLLQLARAGqsfssGHYQTVK 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 310 kqpivfsqLIEDVLDTYEIKFIE----KEIHISTNLNP-EVIVMIDEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQIDD 384
Cdd:PRK10755 207 --------LLEDVILPSQDELSEmleqRQQTLLLPESAaDITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDG 278
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446416941 385 YCELKIKDTGIGIDIEHLENLGERFYRVDkarsRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTT 452
Cdd:PRK10755 279 GAVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHGQFFLQNRQERSGT 342
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
229-460 |
2.92e-26 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 112.34 E-value: 2.92e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 229 ANSLETEDVKRKEFLANVSHELRTPLSYIKGYSEAILDgVAKGPQQEKVTQLIHKEAGRMQRLVHDLLDLAQLEGEHFPL 308
Cdd:PRK11091 273 QDALEKASRDKTTFISTISHELRTPLNGIVGLSRILLD-TELTAEQRKYLKTIHVSAITLGNIFNDIIDMDKMERRKLQL 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 309 KKQPIVFSQLIEDVLDTYEIKFIEKEIHISTNLNPEV--IVMIDEDRMQQVLHNVLDNAIRYTnQKGNIVITL--EQIDD 384
Cdd:PRK11091 352 DNQPIDFTDFLADLENLSGLQAEQKGLRFDLEPLLPLphKVITDGTRLRQILWNLISNAVKFT-QQGGVTVRVryEEGDM 430
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446416941 385 YCeLKIKDTGIGIDIEHLENLGERFYRVDKARSRQHG-GTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKLNVQ 460
Cdd:PRK11091 431 LT-FEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPAtGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHAP 506
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
228-457 |
5.51e-26 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 111.60 E-value: 5.51e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 228 MANSLETEDVKRKEFLANVSHELRTPLSYIKGYseaiLDGVAKGPQQEKVTQLI---HKEAGRMQRLVHDLLDLAQLEGE 304
Cdd:PRK10841 436 MAQAAEQASQSKSMFLATVSHELRTPLYGIIGN----LDLLQTKELPKGVDRLVtamNNSSSLLLKIISDILDFSKIESE 511
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 305 HfpLKKQPIVFS--QLIEDVLDTYEIKFIEKEIHISTNLNPEVIVMIDED--RMQQVLHNVLDNAIRYTNQkGNIVITLE 380
Cdd:PRK10841 512 Q--LKIEPREFSprEVINHITANYLPLVVKKRLGLYCFIEPDVPVALNGDpmRLQQVISNLLSNAIKFTDT-GCIVLHVR 588
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446416941 381 QIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:PRK10841 589 VDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRI 665
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
165-440 |
2.51e-25 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 107.81 E-value: 2.51e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 165 LAPLAIAMILITIWVGRKIiiaitKPLsqmERVANHLATGDFSERITVSSE---DEIGRLGKAFNKMANSLETEDVKRKE 241
Cdd:PRK10337 168 LVALPIMLIILMVLLGREL-----APL---KKLALALRMRDPDSETPLNATgvpSEVRPLVEALNQLFARTHAMMVRERR 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 242 FLANVSHELRTPLSYIKGYSE-AILDGVAKGPQQEKVTQLiHKEAGRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIE 320
Cdd:PRK10337 240 FTSDAAHELRSPLAALKVQTEvAQLSDDDPQARKKALLQL-HAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQ 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 321 D-VLDTYEiKFIEKEIHISTNLN-PEVIVMIDEDRMQQVLHNVLDNAIRYTNQKGNIVITLeqidDYCELKIKDTGIGID 398
Cdd:PRK10337 319 SaVMDIYH-TAQQAGIDVRLTLNaHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTL----NARNFTVRDNGPGVT 393
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 446416941 399 IEHLENLGERFYRvdkARSRQHGGTGLGLAIVKQIVHIHGGQ 440
Cdd:PRK10337 394 PEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGMN 432
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
149-443 |
1.27e-24 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 105.76 E-value: 1.27e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 149 IPLKSIKDliYDmgliLAPL---AIAMILITIWVGRKIIIAITKPLSQMERVANHLATGDFSERITVSSEDEIGRLGKAF 225
Cdd:PRK09467 142 VPLTEIHQ--GD----FSPLfryTLAIGLLSVAGGWLFIRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAF 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 226 NKMANSLETEDVKRKEFLANVSHELRTPLSYIKGYSEAIldgvakGPQQEKVTQLIHKEAGRMQRLVHDLLD-LAQLEGE 304
Cdd:PRK09467 216 NQMAAGIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEMM------SEEDGYLAESINKDIEECNAIIEQFIDyLRTGQEM 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 305 HFplkkQPIVFSQLIEDVLDTyEIKFiekEIHISTNLNP-EVIVMIDEDRMQQVLHNVLDNAIRYTNqkGNIVITLEQID 383
Cdd:PRK09467 290 PM----EMADLNALLGEVIAA-ESGY---EREIETALQPgPIEVPMNPIAIKRALANLVVNAARYGN--GWIKVSSGTEG 359
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 384 DYCELKIKDTGIGIDIEHLENLGERFYRVDKARSRQhgGTGLGLAIVKQIVHIHGGQWKI 443
Cdd:PRK09467 360 KRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVEL 417
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-457 |
1.61e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 97.86 E-value: 1.61e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 345 VIVMIDEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQiDDYCELKIKDTGIGIDIEHLENLGERFYRVDKarsRQHGGTG 424
Cdd:cd16940 5 IQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSA-DDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSG 80
|
90 100 110
....*....|....*....|....*....|...
gi 446416941 425 LGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:cd16940 81 LGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
163-460 |
2.53e-24 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 106.53 E-value: 2.53e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 163 LILAPLAIAMILITIWvgRKIIIAITKPLSQMERVANHLATGD----FSERITVSSEDEIGRLGKAFNKMANSL------ 232
Cdd:PRK11466 334 LLLGMVSLCALILILW--RVVYRSVTRPLAEQTQALQRLLDGDidspFPETAGVRELDTIGRLMDAFRSNVHALnrhreq 411
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 233 --------------------------ETEDVKRKEFLANVSHELRTPLSYIKGYSEAILDGVAKgPQQEKVTQLIHKEAG 286
Cdd:PRK11466 412 laaqvkartaelqelviehrqaraeaEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPAL-NAQRDDLRAITDSGE 490
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 287 RMQRLVHDLLDLAQLE--GEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKEIHISTNLNPEV--IVMIDEDRMQQVLHNVL 362
Cdd:PRK11466 491 SLLTILNDILDYSAIEagGKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDLptALMGDPRRIRQVITNLL 570
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 363 DNAIRYTnQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARsrqhGGTGLGLAIVKQIVHIHGGQWK 442
Cdd:PRK11466 571 SNALRFT-DEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELS 645
|
330
....*....|....*...
gi 446416941 443 IESEKDKGTTVIIKLNVQ 460
Cdd:PRK11466 646 ATSTPEVGSCFCLRLPLR 663
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
214-460 |
2.23e-22 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 100.96 E-value: 2.23e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 214 SEDEIGRLGKAFNKMANSleteDVKRKEFLANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEAGRMQRLVH 293
Cdd:PRK09959 691 TRDLIHALEVERNKAINA----TVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIG 766
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 294 DLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKEIHI--STNLNPEVIVMIDEDRMQQVLHNVLDNAIRYTNQ 371
Cdd:PRK09959 767 EILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALscSSTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTE 846
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 372 KG-NIVITLEQIDD---YCELKIKDTGIGIDIEHLENLGERFYRVdkARSRQHGGTGLGLAIVKQIVHIHGGQWKIESEK 447
Cdd:PRK09959 847 GAvKITTSLGHIDDnhaVIKMTIMDSGSGLSQEEQQQLFKRYSQT--SAGRQQTGSGLGLMICKELIKNMQGDLSLESHP 924
|
250
....*....|...
gi 446416941 448 DKGTTVIIKLNVQ 460
Cdd:PRK09959 925 GIGTTFTITIPVE 937
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-457 |
4.56e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 90.46 E-value: 4.56e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 356 QVLHNVLDNAIRYTNQKgnIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVKQIVH 435
Cdd:cd16949 3 RALENVLRNALRYSPSK--ILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|..
gi 446416941 436 IHGGQWKIESEKDKGTTVIIKL 457
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIWL 102
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-457 |
3.52e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 88.21 E-value: 3.52e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 354 MQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKarSRQHGGTGLGLAIVKQI 433
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....
gi 446416941 434 VHIHGGQWKIESEkDKGTTVIIKL 457
Cdd:cd16923 79 IELHGGSASAEYD-DNHDLFKVRL 101
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
7-462 |
2.14e-20 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 93.16 E-value: 2.14e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 7 KLWLTVVCAVCVTVSFLYFVSLYSYEKLYVDNLKASLVMEGKSLAAQYDKREGISTFEEKVRSFDQISSSDVIFVSNPRD 86
Cdd:COG2972 1 LSKSLSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 87 LSACLPFDVHHHSLISEGDRQTLLDGKTVTKIGYEEHFDRNIMGVVIPVLENKKLVGIVYSYIPLKSIKDLIYDMGLILA 166
Cdd:COG2972 81 LILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 167 PLAIAMILITIWVGRKIIIAITKPLSQMERVANHLATGDFSeRITVSSEDEIGRLGKAFNKMANSLET--EDVKRKE--- 241
Cdd:COG2972 161 LIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLV-RLEVSGNDEIGILARSFNEMVERIKEliEEVYELElek 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 242 ---------------FLANVshelrtpLSYIKGYSEAildgvakgpqqekvtqlihKEAGRMQRLVHDLLDL----AQLE 302
Cdd:COG2972 240 keaelkalqaqinphFLFNT-------LNSIRWLAEL-------------------EDPEEAEEMLEALSKLlrysLSKG 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 303 GEHFPLKKQpIvfsQLIEDVLDTYEIKFiEKEIHISTNLNPEVIVMIDEDRMQQVLhnvLDNAIRY----TNQKGNIVIT 378
Cdd:COG2972 294 DELVTLEEE-L---ELIKSYLEIQKLRF-GDRLEVEIEIDEELLDLLIPKLILQPL---VENAIEHgiepKEGGGTIRIS 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 379 LEQIDDYCELKIKDTGIGIDIEHLENLGERFyrvdkarSRQHGGTGLGLAIVKQIVHIH---GGQWKIESEKDKGTTVII 455
Cdd:COG2972 366 IRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKLYygeEYGLEIESEPGEGTTVTI 438
|
....*..
gi 446416941 456 KLNVQDE 462
Cdd:COG2972 439 RIPLEEE 445
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
134-457 |
8.72e-20 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 92.50 E-value: 8.72e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 134 PVLENKKLVGIVYSYIPLKSIKDLIYD-----MGLILAPLAIAMILITIWVGRkIIIAITKPLSQMERVANhlATGDFSE 208
Cdd:TIGR03785 377 PIWIDTEVLGAVIAEQTTNGIRTLRNSaleklFNVILAIMSIGTLALFGFASW-ISWRIRRLSDDAEAAID--SQGRISG 453
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 209 RITVS-SEDEIGRLGKAFNKMANSLETEDVKRKEFLANVSHELRTPLSYIKgyseAILDGVAKGPQQEKVTQLI---HKE 284
Cdd:TIGR03785 454 AIPASrSRDEIGDLSRSFAQMVARLRQYTHYLENMSSRLSHELRTPVAVVR----SSLENLELQALEQEKQKYLeraREG 529
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 285 AGRMQRLVHDLLDLAQLEG-------EHFPLKKqpiVFSQLIEDVLDTYEIKFIEKEIHIS---TNLNPEVIVmidedrm 354
Cdd:TIGR03785 530 TERLSMILNNMSEATRLEQaiqsaevEDFDLSE---VLSGCMQGYQMTYPPQRFELNIPETplvMRGSPELIA------- 599
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 355 qQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDiehlENLGERFY------RVDKARSRQHggTGLGLA 428
Cdd:TIGR03785 600 -QMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLTVSNEGPPLP----EDMGEQLFdsmvsvRDQGAQDQPH--LGLGLY 672
|
330 340 350
....*....|....*....|....*....|
gi 446416941 429 IVKQIVHIHGGQWKIES-EKDKGTTVIIKL 457
Cdd:TIGR03785 673 IVRLIADFHQGRIQAENrQQNDGVVFRISL 702
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
350-439 |
1.12e-19 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 84.08 E-value: 1.12e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 350 DEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQID-DYCELKIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLA 428
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90
....*....|.
gi 446416941 429 IVKQIVHIHGG 439
Cdd:cd16925 81 IVKEFVELHGG 91
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
163-458 |
1.92e-19 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 91.29 E-value: 1.92e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 163 LILAPLAIAMILITIW--VGRKIIiaitKPLSQMERVANHLATGDFSERITVSSEDEIGRLGKA---FNKMAN----SLE 233
Cdd:COG4192 329 LAIALLSLLLAVLINYfyVRRRLV----KRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIARLlrvFRDQAIektqELE 404
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 234 TEDVKRKEFLAN-----------------------VSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKE--AGRM 288
Cdd:COG4192 405 TEIEERKRIEKNlrqtqdeliqaakmavvgqtmtsLAHELNQPLNAMSMYLFSAKKALEQENYAQLPTSLDKIEglIERM 484
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 289 QRLVHDLldlaqlegEHFPLKK----QPIVFSQLIEDVLDTYEIKfiEKEIHISTNLNPEVIVMIDEDRMQQVLHNVLDN 364
Cdd:COG4192 485 DKIIKSL--------RQFSRKSdtplQPVDLRQVIEQAWELVESR--AKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVN 554
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 365 AIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIehLENLGERFYrvdkarSRQHGGTGLGLAIVKQIVHIHGGQWKIE 444
Cdd:COG4192 555 ALDAVATQPQISVDLLSNAENLRVAISDNGNGWPL--VDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYLA 626
|
330
....*....|....
gi 446416941 445 SEKDKGTTVIIKLN 458
Cdd:COG4192 627 STLERGAMVILEFN 640
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-456 |
9.91e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 81.35 E-value: 9.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 350 DEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARsRQHGGTGLGLAI 429
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79
|
90 100
....*....|....*....|....*..
gi 446416941 430 VKQIVHIHGGQWKIESEKDKGTTVIIK 456
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGAEVTVK 106
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-457 |
1.37e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 80.83 E-value: 1.37e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 354 MQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCE--LKIKDTGIGIDIEHLENLGERFYRVDKarSRQHGGTGLGLAIVK 431
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEwtFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*.
gi 446416941 432 QIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTL 104
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
239-300 |
6.82e-18 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 77.64 E-value: 6.82e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446416941 239 RKEFLANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEAGRMQRLVHDLLDLAQ 300
Cdd:cd00082 4 KGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
247-462 |
3.65e-17 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 82.97 E-value: 3.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 247 SHELRTPLSYIKGYSEAIldgvakgpQQEKVTQLIHKEAGRMQRLVHDLLDlaqlegehfplKKQPIVFSQLIEDVLDTY 326
Cdd:COG3290 197 RHDFRNHLHTISGLLQLG--------EYDEALEYIDEISEELQELIDSLLS-----------RIGNPVLAALLLGKAARA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 327 EIKFIEKEIHISTNLNPEVIVMIDEDRmqqVLHNVLDNAIRYT----NQKGNIVITLEQIDDYCELKIKDTGIGIDIEHL 402
Cdd:COG3290 258 RERGIDLTIDIDSDLPDLPLSDTDLVT---ILGNLLDNAIEAVeklpEEERRVELSIRDDGDELVIEVEDSGPGIPEELL 334
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 403 ENLGERFYRvdkarSRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKLNVQDE 462
Cdd:COG3290 335 EKIFERGFS-----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
238-304 |
4.27e-17 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 75.33 E-value: 4.27e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446416941 238 KRKEFLANVSHELRTPLSYIKGYSEAILDGVAkGPQQEKVTQLIHKEAGRMQRLVHDLLDLAQLEGE 304
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKL-DEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-457 |
1.14e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 76.52 E-value: 1.14e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 318 LIEDVLDTYEIKFIEKEIHISTNLNPEVIVMIDEDRMQQVLHNVLDNAIRYTNqkGNIVITLEQIDDYCELKIKDTGIGI 397
Cdd:cd16954 2 LLDSLCSALNKVYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCL--EFVEVTARQTDGGLHLIVDDDGPGV 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 398 DIEHLENLGERFYRVDkarsRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:cd16954 80 PESQRSKIFQRGQRLD----EQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
238-304 |
1.45e-16 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 73.75 E-value: 1.45e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446416941 238 KRKEFLANVSHELRTPLSYIKGYSEAILDGvAKGPQQEKVTQLIHKEAGRMQRLVHDLLDLAQLEGE 304
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDT-ELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-439 |
2.88e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 74.39 E-value: 2.88e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 354 MQQVLHNVLDNAIRYTNQKGNIVITLEqiDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVKQI 433
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVS--GGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
....*.
gi 446416941 434 VHIHGG 439
Cdd:cd16939 79 ALWHGG 84
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-457 |
8.88e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 72.84 E-value: 8.88e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 353 RMQ--QVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARSrqhgGTGLGLAIV 430
Cdd:cd16943 1 PSQlnQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLS 76
|
90 100
....*....|....*....|....*..
gi 446416941 431 KQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIIL 103
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
188-232 |
1.13e-15 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 70.55 E-value: 1.13e-15
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 446416941 188 TKPLSQMERVANHLATGDFSERITVSSEDEIGRLGKAFNKMANSL 232
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-440 |
1.66e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 72.10 E-value: 1.66e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 354 MQQVLHNVLDNAIRYTNqkGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARSRqhGGTGLGLAIVKQI 433
Cdd:cd16950 1 LKRVLSNLVDNALRYGG--GWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGT--SGTGLGLAIVQRI 76
|
....*..
gi 446416941 434 VHIHGGQ 440
Cdd:cd16950 77 SDAHGGS 83
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-450 |
3.59e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 71.34 E-value: 3.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 354 MQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARSRQHgGTGLGLAIVKQI 433
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQK-STGLGLAFVQEV 83
|
90
....*....|....*..
gi 446416941 434 VHIHGGQWKIESEKDKG 450
Cdd:cd16945 84 AQLHGGRITLRNRPDGV 100
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
246-460 |
1.88e-14 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 75.87 E-value: 1.88e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 246 VSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEAGRMQRLVHDLLDLaqleGEHFPLKKQPIVFSQLIEDVL-- 323
Cdd:PRK13837 457 IAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQILAF----GRKGERNTKPFDLSELVTEIApl 532
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 324 ------DTYEIKF-IEKEIHISTNlNPEvivmidedRMQQVLHNVLDNAIRYTNQKGNIVITLEQID------------- 383
Cdd:PRK13837 533 lrvslpPGVELDFdQDQEPAVVEG-NPA--------ELQQVLMNLCSNAAQAMDGAGRVDISLSRAKlrapkvlshgvlp 603
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446416941 384 --DYCELKIKDTGIGIDIEHLENLGERFYrvdKARSrqhGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKLNVQ 460
Cdd:PRK13837 604 pgRYVLLRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPS 676
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-455 |
4.54e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 68.08 E-value: 4.54e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 350 DEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARsRQHGGTGLGLAI 429
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYL 80
|
90 100
....*....|....*....|....*.
gi 446416941 430 VKQIVHIHGGQWKIESEKDKGTTVII 455
Cdd:cd16948 81 VKKLCDKLGHKIDVESEVGEGTTFTI 106
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-457 |
1.02e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 67.54 E-value: 1.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 350 DEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAI 429
Cdd:cd16947 17 NTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTI 96
|
90 100
....*....|....*....|....*...
gi 446416941 430 VKQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:cd16947 97 TKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HAMP |
pfam00672 |
HAMP domain; |
183-234 |
1.25e-13 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 64.95 E-value: 1.25e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 446416941 183 IIIAITKPLSQMERVANHLATGDFSERITVSSEDEIGRLGKAFNKMANSLET 234
Cdd:pfam00672 2 LARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
41-460 |
1.84e-13 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 72.45 E-value: 1.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 41 ASLVMEGKSLAAQYDKREGISTFEEKVRSFDQISSSDVIFVSNPRDLSACLPFDVHHHSLISEGDRQTLLDGKTVTKIGY 120
Cdd:COG2770 95 LLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELL 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 121 EEHFDRNIMGVVIPVLENKKLVGIVYSYIPLKSIKDLIYDMGLILAPLAIAmILITIWVGRKIiiaiTKPLSQMERVANH 200
Cdd:COG2770 175 LLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLA-LLLALLLARRI----TRPLRRLAEAARR 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 201 LATGDFSERITVSSEDEIGRLGKAFNKMANSLET------EDVKRKEFLANVSHELRTPLSYIKGYSEAILDGVAKGPQQ 274
Cdd:COG2770 250 IAAGDLDVRIPVSRKDEIGELARAFNRMADSLREsieeaeEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALL 329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 275 EKVTQLIHKEAGRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKEIHISTNLNPEVIVMIDEDRM 354
Cdd:COG2770 330 LELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELAL 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 355 QQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVKQIV 434
Cdd:COG2770 410 EELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALEL 489
|
410 420
....*....|....*....|....*.
gi 446416941 435 HIHGGQWKIESEKDKGTTVIIKLNVQ 460
Cdd:COG2770 490 LLLEEEEEAGAAAEELAEELLLLEGL 515
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
164-463 |
2.89e-13 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 71.45 E-value: 2.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 164 ILAPLAIAMILITIWVGRKIIIAITKPLSQMERVANHLATGDFSERITVSSEDEIGRLGKAFNKMAN-------SLETED 236
Cdd:COG3850 119 LALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADelqelyaELEEEE 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 237 VKRKEFLANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEAGRMQRLVHDLLDLAQLEGEHFPLKKQPIVFS 316
Cdd:COG3850 199 ELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASAL 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 317 QLIEDVLDTYEIKFIEKEIHISTNLNPEVIVMIDEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQIDDYCELKIKDTGIG 396
Cdd:COG3850 279 LLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAAAA 358
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446416941 397 IDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKLNVQDEG 463
Cdd:COG3850 359 GAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVAGEGGLVVLIVSIIA 425
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
187-234 |
3.23e-13 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 63.81 E-value: 3.23e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 446416941 187 ITKPLSQMERVANHLATGDFSERITVSSEDEIGRLGKAFNKMANSLET 234
Cdd:smart00304 3 LLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEE 50
|
|
| ArsS_fam_HK |
NF038389 |
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ... |
168-438 |
3.41e-13 |
|
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.
Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 71.03 E-value: 3.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 168 LAIAMILITIWVGRKIiiaitKPLSQMERVANHLATGDFSERITVSSEDEIGRLGKAFNKMANSLETEDVKRKEFLANVS 247
Cdd:NF038389 140 LILLLLILYISVLKSL-----KPLKKLKKQIKKFANGDFDFIKSESNGDEIGEVANEFDKAVKKIKALNESRQLFLRNIM 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 248 HELRTPLSyiKG--YSEAILDGVakgpQQEKVTQLIHkeagRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDt 325
Cdd:NF038389 215 HELKTPIT--KGriVAEMLEDEK----QKERLISIFE----RLESLINEFAKIEQLTSKNYKLNKKEYRLSDIIDEAID- 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 326 yeIKFIEKEIHISTNLNPEVIVMIDEDRMQQVLHNVLDNAIRYTNQKgniVITLEQIDDYceLKIKDTGIGIDIEhLENL 405
Cdd:NF038389 284 --MLMIDDSSVIIKVSLEDFKLNVDFELFSLAIKNLIDNAIKYSPDK---KVTIEIKGDK--IEFKNKGEPLEEP-LEYY 355
|
250 260 270
....*....|....*....|....*....|...
gi 446416941 406 GERFYrvdKARSRQHGGTGLGLAIVKQIVHIHG 438
Cdd:NF038389 356 FEPFF---KGNEKSKSGFGLGLYIVKNILKAHG 385
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
124-234 |
1.13e-12 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 70.05 E-value: 1.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 124 FDRNIMGVVIPVLENKKLVGIVYSYIPLKSIKDLIYDMGLILAPLAIAMILITIWVGRKIIIAITKPLSQMERVANHLAT 203
Cdd:COG0840 143 LALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAE 222
|
90 100 110
....*....|....*....|....*....|.
gi 446416941 204 GDFSERITVSSEDEIGRLGKAFNKMANSLET 234
Cdd:COG0840 223 GDLTVRIDVDSKDEIGQLADAFNRMIENLRE 253
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-457 |
4.20e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 62.59 E-value: 4.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 356 QVLHNVLDNAIRYT-NQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFY--RVDKARSRQHggTGLGLAIVKQ 432
Cdd:cd16953 3 QVLRNLIGNAISFSpPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYteRPANEAFGQH--SGLGLSISRQ 80
|
90 100
....*....|....*....|....*....
gi 446416941 433 IVHIHGGQWKIESEKD----KGTTVIIKL 457
Cdd:cd16953 81 IIEAHGGISVAENHNQpgqvIGARFTVQL 109
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
291-461 |
7.97e-11 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 64.16 E-value: 7.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 291 LVHDLLdlaqLEGEHFplkkQPIVFSQLIEDVLDTYEIKFIEKEIHISTNLNPeviVMIDEDRMQQ---VLHNVLDNAIR 367
Cdd:COG3920 345 LVHELL----YQSEDW----EGVDLRDYLRELLEPLRDSYGGRGIRIELDGPD---VELPADAAVPlglILNELVTNALK 413
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 368 Y---TNQKGNIVITLEQIDDYCELKIKDTGIGIDIEhlenlgerfyrVDKARSRqhggtGLGLAIVKQIVHIHGGQWKIE 444
Cdd:COG3920 414 HaflSGEGGRIRVSWRREDGRLRLTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRALVRQLGGTLELD 477
|
170
....*....|....*..
gi 446416941 445 SekDKGTTVIIKLNVQD 461
Cdd:COG3920 478 R--PEGTRVRITFPLAE 492
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
239-460 |
9.72e-11 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 64.18 E-value: 9.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 239 RKEFLANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIhKEAGRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQL 318
Cdd:PRK10618 450 RKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPELDQLA-EQSDVLVRLVDNIQLLNMLETQDWKPEQELFSLQDL 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 319 IEDVLDTYEIKFIEK--EIHISTNLNPEVIVMIDEDRMQQVLHNVLDNAIRyTNQKGNIVITLEQIDDYCE---LKIKDT 393
Cdd:PRK10618 529 IDEVLPEVLPAIKRKglQLLIHNHLKAEQLRIGDRDALRKILLLLLNYAIT-TTAYGKITLEVDQDESSPDrltIRILDT 607
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446416941 394 GIGIDIEHLENLgeRFYRVDKARSRQHG-GTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKLNVQ 460
Cdd:PRK10618 608 GAGVSIKELDNL--HFPFLNQTQGDRYGkASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLKML 673
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-457 |
2.10e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 57.68 E-value: 2.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 357 VLHNVLDNAI----RYTNQKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRvdkarSRQHGGTGLGLAIVKQ 432
Cdd:cd16915 4 IVGNLIDNALdalaATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQ 78
|
90 100
....*....|....*....|....*
gi 446416941 433 IVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:cd16915 79 SVERLGGSITVESEPGGGTTFSIRI 103
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
246-453 |
4.88e-10 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 61.61 E-value: 4.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 246 VSHELRTPLSYIKGYSEAILDGVAKG-PQQEKVTQLIH---KEAGRMQRLVHDLLDLA---QLEGehfplkkQPIVFSQL 318
Cdd:PRK13557 170 IAHDFNNLLQVMSGYLDVIQAALSHPdADRGRMARSVEnirAAAERAATLTQQLLAFArkqRLEG-------RVLNLNGL 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 319 IEDVLDTYEIKFIEkEIHISTNLNPEVI-VMIDEDRMQQVLHNVLDNAIRYTNQKGNIVITLEQID-------------- 383
Cdd:PRK13557 243 VSGMGELAERTLGD-AVTIETDLAPDLWnCRIDPTQAEVALLNVLINARDAMPEGGRVTIRTRNVEiededlamyhglpp 321
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446416941 384 -DYCELKIKDTGIGIDIEHLENLGERFYRvdkarSRQHG-GTGLGLAIVKQIVHIHGGQWKIESEKDKGTTV 453
Cdd:PRK13557 322 gRYVSIAVTDTGSGMPPEILARVMDPFFT-----TKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTV 388
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-450 |
7.49e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 55.93 E-value: 7.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 354 MQQVLHNVLDNAIRYTN--QKGNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYRvdkarSRQHG-GTGLGLAIV 430
Cdd:cd16976 1 IQQVLMNLLQNALDAMGkvENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|
gi 446416941 431 KQIVHIHGGQWKIESEKDKG 450
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAG 95
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
240-452 |
1.06e-09 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 59.71 E-value: 1.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 240 KEFLANVSHELRTPLSYIKGYSEaILDGVAKGPQQEKVTQLIHKEAGRMQRLVHDLLdlaqleGEHFPLKKQPIVFSQLI 319
Cdd:PRK11073 131 RDLVRGLAHEIKNPLGGLRGAAQ-LLSKALPDPALTEYTKVIIEQADRLRNLVDRLL------GPQRPGTHVTESIHKVA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 320 EDVLDTYEIKF-----IEKEIHISTnlnPEVivMIDEDRMQQVLHNVLDNAIRYTNQK-GNIVI---TLEQIDDY----- 385
Cdd:PRK11073 204 ERVVQLVSLELpdnvrLIRDYDPSL---PEL--AHDPDQIEQVLLNIVRNALQALGPEgGTITLrtrTAFQLTLHgeryr 278
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446416941 386 --CELKIKDTGIGIDIEHLENLgerFYRVDKARSrqhGGTGLGLAIVKQIVHIHGGqwKIESEKDKGTT 452
Cdd:PRK11073 279 laARIDIEDNGPGIPPHLQDTL---FYPMVSGRE---GGTGLGLSIARNLIDQHSG--KIEFTSWPGHT 339
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-457 |
1.26e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 55.62 E-value: 1.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 350 DEDRMQQVLHNVLDNA---------------IRY-TNQKGNIVITleqiddycelkIKDTGIGIDIEHLENLGERfYRVD 413
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaiegrpsdvgevrIRVeADQDGRIVLI-----------VCDNGKGFPREMRHRATEP-YVTT 68
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 446416941 414 KARsrqhgGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:cd16944 69 RPK-----GTGLGLAIVKKIMEEHGGRISLSNREAGGACIRIIL 107
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
243-440 |
1.40e-09 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 60.03 E-value: 1.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 243 LANVSHELRTPLSYIKGYSEAIldgvaKGPQQEKVTQ---LIHKEAGRMQRLVHDLLDLAQLEGEHFPLKKQ----PIVF 315
Cdd:PRK10815 270 LTDLTHSLKTPLAVLQSTLRSL-----RSGKQMSVEQaepIMLEQISRISQQIGYYLHRASMRSEHNLLSRElhsvAPLL 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 316 SQLIEDVLDTYEikfiEKEIHISTNLNPEVIVMIDEDRMQQVLHNVLDNAIRYTNQkgNIVITLEQIDDYCELKIKDTGI 395
Cdd:PRK10815 345 DNLTSALNKVYQ----RKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLE--FVEISARQTDEHLHIVVEDDGP 418
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 446416941 396 GIDIEHLENLGERFYRVDKARSrqhgGTGLGLAIVKQIVHIHGGQ 440
Cdd:PRK10815 419 GIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGK 459
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
384-457 |
2.99e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 54.69 E-value: 2.99e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446416941 384 DYCELKIKDTGIGIDIEHLENLGERFYRVDKARSrqhgGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKL 457
Cdd:cd16919 46 NYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGK----GTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
352-459 |
5.73e-09 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 54.15 E-value: 5.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 352 DRMQQVLHNVLDNAIRYTNQ---KGNIVITLEQIDDYCELKIKDTGIGIDIEHLEnlgerfyrvDKARSRQHGgtGLGLA 428
Cdd:COG2172 33 DDLVLAVSEAVTNAVRHAYGgdpDGPVEVELELDPDGLEIEVRDEGPGFDPEDLP---------DPYSTLAEG--GRGLF 101
|
90 100 110
....*....|....*....|....*....|.
gi 446416941 429 IVKQIVHihggQWKIESEKDkGTTVIIKLNV 459
Cdd:COG2172 102 LIRRLMD----EVEYESDPG-GTTVRLVKRL 127
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
254-462 |
1.05e-08 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 55.78 E-value: 1.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 254 LSYIKGYSEAILDGVAKGPQQ-EKVTQLIHKEAGRMQRLVHDLL-DLAQLEGEHFPLKKQpivFSQLIEDVLDTYEIKFi 331
Cdd:COG4585 69 LSAIKLQLEAARRLLDADPEAaREELEEIRELAREALAELRRLVrGLRPPALDDLGLAAA---LEELAERLLRAAGIRV- 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 332 ekEIHISTNLNPevivmIDEDRMQQVLHNV---LDNAIRYTnQKGNIVITLEQIDDYCELKIKDTGIGIDIEhlenlger 408
Cdd:COG4585 145 --ELDVDGDPDR-----LPPEVELALYRIVqeaLTNALKHA-GATRVTVTLEVDDGELTLTVRDDGVGFDPE-------- 208
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 446416941 409 fyrvdkarsrQHGGTGLGLAIVKQIVHIHGGQWKIESEKDKGTTVIIKLNVQDE 462
Cdd:COG4585 209 ----------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-452 |
1.16e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 52.78 E-value: 1.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 354 MQQVLHNVLDNAIR----YTNQKGNIVITLEQIDD-YCELKIKDTGIGIDIEHLENLGERFYRVDKArsrqhgGTGLGLA 428
Cdd:cd16920 1 IQQVLINLVRNGIEamseGGCERRELTIRTSPADDrAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLS 74
|
90 100
....*....|....*....|....
gi 446416941 429 IVKQIVHIHGGQWKIESEKDKGTT 452
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGAT 98
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-453 |
1.63e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 49.32 E-value: 1.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 354 MQQVLHNVLDNAIRYTNQKGNIVITLEQIDDY-----------CELKIKDTGIGIDIEHLENLgerFYRVDKARSrqhGG 422
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGGEIILRTRTQRQvtlghprhrlaLRVSVIDNGPGIPPDLQDTI---FYPMVSGRE---NG 74
|
90 100 110
....*....|....*....|....*....|.
gi 446416941 423 TGLGLAIVKQIVHIHGGqwKIESEKDKGTTV 453
Cdd:cd16918 75 TGLGLAIAQNIVSQHGG--VIECDSQPGHTV 103
|
|
| ActS_PrrB_HisK |
NF033792 |
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ... |
248-431 |
3.39e-07 |
|
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.
Pssm-ID: 468186 [Multi-domain] Cd Length: 423 Bit Score: 52.52 E-value: 3.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 248 HELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEAGRMQRLVHDLLDLAQLEGEHFplKKQPIvfSQLIEDVLDTYe 327
Cdd:NF033792 211 HELGTPLATIALVAKELERELPDDPPLREDAELLRSQAERCRDILRRLTSLGEEGDAHL--DRLPL--SALIEEAAAPH- 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 328 IKFiEKEIHISTNLNPEVIVMIdeDRMQQVLH---NVLDNAIRYTnqKGNIVITLEQIDDYCELKIKDTGIGIDIEHLEN 404
Cdd:NF033792 286 RGF-GKEIEVVVAGDPGEEPVI--RRNPEILYglgNLIENAVDFA--RSTVTVTASWDAESVTITIEDDGPGFPPDVLSR 360
|
170 180
....*....|....*....|....*....
gi 446416941 405 LGERFY--RVDKARSRQHGGTGLGLAIVK 431
Cdd:NF033792 361 IGEPYVttRRGEERRPGGGGLGLGLFIAK 389
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
357-457 |
4.06e-07 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 52.22 E-value: 4.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 357 VLHNVLDNAIRYTNQK--GNIVITLEQIDDYCELKIKDTGIGIDIEHLENLGERFYrvdkarSRQHGGTGLGLAIVKQIV 434
Cdd:PRK11086 437 ILGNLIENALEAVGGEegGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGVGLYLVKQSV 510
|
90 100
....*....|....*....|...
gi 446416941 435 HIHGGQWKIESEKDKGTTVIIKL 457
Cdd:PRK11086 511 ENLGGSIAVESEPGVGTQFFVQI 533
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
161-234 |
7.26e-06 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 48.31 E-value: 7.26e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446416941 161 MGLILAplaiaMILITIWVGRKiiiAITKPLSQMERVANHLATGDFSE-RITVSSEDEIGRLGKAFNKMANSLET 234
Cdd:PRK10935 158 LILILT-----LVFFTVRFTRR---QVVAPLNQLVTASQQIEKGQFDHiPLDTTLPNELGLLAKAFNQMSSELHK 224
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
161-232 |
7.53e-06 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 48.51 E-value: 7.53e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446416941 161 MGLILAPLAIAMIlitIWVGRKIIiaitKPLSQMERVANHLATGDFSERITVSSEDEIGRLGKAFNKMANSL 232
Cdd:PRK10600 130 FAVFMALLLVFTI---IWLRRRLL----QPWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSAEL 194
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-457 |
8.03e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 41.00 E-value: 8.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 362 LDNAIRYTNQKGnIVITLEQIDDYCELKIKDTGIGIDiehlenlgerfyrvDKARSrqhGGTGLGLAIVKQIVHIHGGQW 441
Cdd:cd16917 9 LTNALKHAGASR-VRVTLSYTADELTLTVVDDGVGFD--------------GPAPP---GGGGFGLLGMRERAELLGGTL 70
|
90
....*....|....*.
gi 446416941 442 KIESEKDKGTTVIIKL 457
Cdd:cd16917 71 TIGSRPGGGTRVTARL 86
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-458 |
5.26e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 39.37 E-value: 5.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 354 MQQVLHNVLDNAIRYTNQKGNIVITL-EQIDDYCELKIKDTGIGIDIEHLENLgerfyrvdkaRSRQHGGTGLGLAIVKQ 432
Cdd:cd16955 6 IQPLVENAIVHGIQEKKGKGVVKISVkKQLKNRLHIAVEDNGIGISPKVIERV----------EQDEMPGNKIGLLNVHQ 75
|
90 100
....*....|....*....|....*..
gi 446416941 433 -IVHIHGGQWKIESEKDKGTTVIIKLN 458
Cdd:cd16955 76 rLKLGYGEGLHIRSRPDPGTLIAFYIP 102
|
|
| PRK15041 |
PRK15041 |
methyl-accepting chemotaxis protein; |
163-232 |
9.56e-04 |
|
methyl-accepting chemotaxis protein;
Pssm-ID: 185001 [Multi-domain] Cd Length: 554 Bit Score: 41.48 E-value: 9.56e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 163 LILAPLAIAMILITIWVGrkIIIAITKPLSQMERVANHLATGDFSERITVSSEDEIGRLGKAFNKMANSL 232
Cdd:PRK15041 196 LVGVMIVVLAVIFAVWFG--IKASLVAPMNRLIDSIRHIAGGDLVKPIEVDGSNEMGQLAESLRHMQGEL 263
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
362-457 |
2.27e-03 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 40.35 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 362 LDNAIRYTNQKgNIVITLEQIDDYCELKIKDTGIGIDIEHLEnlgerfyrvdkarsrqhggTGLGLAIVKQIVHIHGGQW 441
Cdd:PRK11644 419 LNNIVKHADAS-AVTLQGWQQDERLMLVIEDDGSGLPPGSGQ-------------------QGFGLRGMRERVTALGGTL 478
|
90
....*....|....*.
gi 446416941 442 KIESekDKGTTVIIKL 457
Cdd:PRK11644 479 TISC--THGTRLSVSL 492
|
|
| HATPase_Phy-like |
cd16932 |
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ... |
350-455 |
4.28e-03 |
|
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.
Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 36.87 E-value: 4.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 350 DEDRMQQVLHNVLDNAIRYTNQKGN-----IVITLEQIDD-----YCELKIKDTGIGIDiehlENLGERFYRVDKARSRQ 419
Cdd:cd16932 3 DQIRLQQVLADFLLNAVRFTPSPGGwveikVSPTKKQIGDgvhviHLEFRITHPGQGLP----EELVQEMFEENQWTTQE 78
|
90 100 110
....*....|....*....|....*....|....*.
gi 446416941 420 hggtGLGLAIVKQIVHIHGGQWKIESEKDKGTTVII 455
Cdd:cd16932 79 ----GLGLSISRKLVKLMNGDVRYLREAGRSYFLIT 110
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
358-457 |
6.26e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 36.26 E-value: 6.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 358 LHNVLDNAIRY-TNQK---GNIVITLEQIDDYCELKIKDTGIGIDiehlenlgerfyRVDKARSRQHGGTGLGLAIV-KQ 432
Cdd:cd16956 6 LQPIVENAVKHgLSGLldgGRVEITARLDGQHLLLEVEDNGGGMD------------PDTLARILIRSSNGLGLNLVdKR 73
|
90 100
....*....|....*....|....*..
gi 446416941 433 IVHIHGGQW--KIESEKDKGTTVIIKL 457
Cdd:cd16956 74 LRQAFGNDYglDIECAPGEGTRITIRL 100
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
364-457 |
7.74e-03 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 35.71 E-value: 7.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 364 NAIRYTN---QKGNIVITLEQIDDYCELKIKDTGIGIDiehlenlgerfYRVDKARSRQHGGTGLGLAIVKQIVHihggQ 440
Cdd:cd16936 11 NAVRHAYrhdGPGPVRLELDLDPDRLRVEVTDSGPGFD-----------PLRPADPDAGLREGGRGLALIRALMD----E 75
|
90
....*....|....*..
gi 446416941 441 WKIESEkDKGTTVIIKL 457
Cdd:cd16936 76 VGYRRT-PGGKTVWLEL 91
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-457 |
7.87e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 35.88 E-value: 7.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446416941 357 VLHNVLDNAIRYTNQ----KGNIVITLEQIDDYCELKIKDTGIGIDiEHLENLGERfyrvdkarsRQHGGTGLGLAIVKQ 432
Cdd:cd16924 5 TLQPLVENAIQHGLSpltdKGVVTISALKEDNHVMIEVEDNGRGID-PKVLNILGK---------KPKEGNGIGLYNVHQ 74
|
90 100
....*....|....*....|....*...
gi 446416941 433 -IVHIHGGQW--KIESEKDKGTTVIIKL 457
Cdd:cd16924 75 rLILLFGEDYgiHIASEPDKGTRITFTI 102
|
|
| |
