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Conserved domains on  [gi|446417112|ref|WP_000494967|]
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MULTISPECIES: lytic transglycosylase domain-containing protein [Enterobacterales]

Protein Classification

lytic transglycosylase domain-containing protein( domain architecture ID 12989917)

lytic transglycosylase domain-containing protein similar to phage exolysin that catalyzes the cleavage of the host peptidoglycans during virus entry

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 30-140 5.42e-36

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


:

Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 121.10  E-value: 5.42e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446417112  30 FGIDAELVFTLFDNEGGKVGTF-SRNTNGTYDIGPMQINSSNLPEIKKHFPTVtwRVLAYDACASFWVGTWWLYRKIvDR 108
Cdd:cd13400    1 YGVPPRLLRAIAKVESGFNPNAiNRNKNGSYDIGLMQINSIWLPELARYGITR--EELLNDPCTNIYVGAWILARNI-KR 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446417112 109 KGNVFEGIADYNSKTPKVRAKYIFNFMVKYNR 140
Cdd:cd13400   78 YGNTWKAVGAYNSGTPKKNDKYARKVYRIYRR 109
 
Name Accession Description Interval E-value
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 30-140 5.42e-36

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 121.10  E-value: 5.42e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446417112  30 FGIDAELVFTLFDNEGGKVGTF-SRNTNGTYDIGPMQINSSNLPEIKKHFPTVtwRVLAYDACASFWVGTWWLYRKIvDR 108
Cdd:cd13400    1 YGVPPRLLRAIAKVESGFNPNAiNRNKNGSYDIGLMQINSIWLPELARYGITR--EELLNDPCTNIYVGAWILARNI-KR 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446417112 109 KGNVFEGIADYNSKTPKVRAKYIFNFMVKYNR 140
Cdd:cd13400   78 YGNTWKAVGAYNSGTPKKNDKYARKVYRIYRR 109
PRK13888 PRK13888
conjugal transfer protein TrbN; Provisional
 22-179 7.83e-21

conjugal transfer protein TrbN; Provisional


Pssm-ID: 237545  Cd Length: 206  Bit Score: 84.88  E-value: 7.83e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446417112  22 CITDAARFFGIDAELVFTLFDNEGGKVGTFSRNTNGTYDIGPMQINSSNLPEIKKHfpTVTWRVLAYDACASFWVGTWWL 101
Cdd:PRK13888  17 CSISAAVKYEVPANIVLAVAEKEGGKPGQWVRNTNGTHDVGPMQFNTAYLGDLARY--GITANDVAAAGCYSFDLAAWRL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446417112 102 YRKIVDRKGNVFEGIADYNSKTPKVRAKYIFNFMV---KYNRRIQQRNGMGELYQWTQQPPRYNGHIAKNVPEQ---NPT 175
Cdd:PRK13888  95 RMHIRNDKGDLWTKAANYHSRTPQYNAVYRADLMRkasKWADWLEARFVTLDVTKAGATPSTPSQPATVAQRATpaaRPA 174


                 ....
gi 446417112 176 PVVK 179
Cdd:PRK13888 175 PAPK 178
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 26-127 6.41e-03

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 34.98  E-value: 6.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446417112   26 AARFFGIDAELVFTLFDNEGGkvgtFSRN-TNGTYDIGPMQINSSNLPEIKKhfPTVTWRVLAYDACASFWVGTWWLYRK 104
Cdd:pfam01464   4 AAQKYGVDPSLLLAIAQQESG----FNPKaVSKSGAVGLMQIMPSTAKRLGL--RVNPGVDDLFDPEKNIKAGTKYLKEL 77

                          90       100
                  ....*....|....*....|...
gi 446417112  105 IVDRKGNVFEGIADYNSKTPKVR 127
Cdd:pfam01464  78 YKQYGGDLWLALAAYNAGPGRVR 100
 
Name Accession Description Interval E-value
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 30-140 5.42e-36

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 121.10  E-value: 5.42e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446417112  30 FGIDAELVFTLFDNEGGKVGTF-SRNTNGTYDIGPMQINSSNLPEIKKHFPTVtwRVLAYDACASFWVGTWWLYRKIvDR 108
Cdd:cd13400    1 YGVPPRLLRAIAKVESGFNPNAiNRNKNGSYDIGLMQINSIWLPELARYGITR--EELLNDPCTNIYVGAWILARNI-KR 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446417112 109 KGNVFEGIADYNSKTPKVRAKYIFNFMVKYNR 140
Cdd:cd13400   78 YGNTWKAVGAYNSGTPKKNDKYARKVYRIYRR 109
PRK13888 PRK13888
conjugal transfer protein TrbN; Provisional
 22-179 7.83e-21

conjugal transfer protein TrbN; Provisional


Pssm-ID: 237545  Cd Length: 206  Bit Score: 84.88  E-value: 7.83e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446417112  22 CITDAARFFGIDAELVFTLFDNEGGKVGTFSRNTNGTYDIGPMQINSSNLPEIKKHfpTVTWRVLAYDACASFWVGTWWL 101
Cdd:PRK13888  17 CSISAAVKYEVPANIVLAVAEKEGGKPGQWVRNTNGTHDVGPMQFNTAYLGDLARY--GITANDVAAAGCYSFDLAAWRL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446417112 102 YRKIVDRKGNVFEGIADYNSKTPKVRAKYIFNFMV---KYNRRIQQRNGMGELYQWTQQPPRYNGHIAKNVPEQ---NPT 175
Cdd:PRK13888  95 RMHIRNDKGDLWTKAANYHSRTPQYNAVYRADLMRkasKWADWLEARFVTLDVTKAGATPSTPSQPATVAQRATpaaRPA 174


                 ....
gi 446417112 176 PVVK 179
Cdd:PRK13888 175 PAPK 178
PRK15328 PRK15328
type III secretion system invasion protein IagB;
19-161 6.03e-13

type III secretion system invasion protein IagB;


Pssm-ID: 185228 [Multi-domain]  Cd Length: 160  Bit Score: 63.35  E-value: 6.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446417112  19 YTQCITDAARFFGIDAELVFTLFDNEGG-KVGTFSRNTNGTYDIGPMQINSSNLPEIKKHfpTVTWRVLAYDACASFWVG 97
Cdd:PRK15328  18 WADCWLQAEKMFNIESELLYAIAQQESAmKPGAIGHNRDGSTDLGLMQINSFHMKRLKKM--GISEKQLLQDPCISVIVG 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446417112  98 TWWLyRKIVDRKGNVFEGIADYNSKTPKVRAkyifNFMVKYNRRIQQRngmgelYQWTQQPPRY 161
Cdd:PRK15328  96 ASIL-SDMMKIYGYSWEAVGAYNAGTSPKRS----DIRKRYAKKIWEN------YRKLKGMSAE 148
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 26-127 6.41e-03

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 34.98  E-value: 6.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446417112   26 AARFFGIDAELVFTLFDNEGGkvgtFSRN-TNGTYDIGPMQINSSNLPEIKKhfPTVTWRVLAYDACASFWVGTWWLYRK 104
Cdd:pfam01464   4 AAQKYGVDPSLLLAIAQQESG----FNPKaVSKSGAVGLMQIMPSTAKRLGL--RVNPGVDDLFDPEKNIKAGTKYLKEL 77

                          90       100
                  ....*....|....*....|...
gi 446417112  105 IVDRKGNVFEGIADYNSKTPKVR 127
Cdd:pfam01464  78 YKQYGGDLWLALAAYNAGPGRVR 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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