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Conserved domains on  [gi|446420104|ref|WP_000497959|]
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iron uptake transporter permease EfeU [Escherichia coli]

Protein Classification

FTR1 family protein( domain architecture ID 10015504)

FTR1 family protein may function as an iron permease involved in high affinity iron transport; similar to Escherichia coli iron permease EfeU

Gene Ontology:  GO:0005381|GO:0034755|GO:0033573
TCDB:  9.A.10.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TIGR00145 TIGR00145
FTR1 family protein; A characterized member from yeast acts as oxidase-coupled high affinity ...
1-274 7.05e-90

FTR1 family protein; A characterized member from yeast acts as oxidase-coupled high affinity iron transporter. Note that the apparent member from E. coli K12-MG1655 has a frameshift by homology with member sequences from other species. [Unknown function, General]


:

Pssm-ID: 272930  Cd Length: 283  Bit Score: 268.14  E-value: 7.05e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104    1 MFVPFLIMLREGLEAALIVSLIASYLKRTQRGRWIGVMWIGVLLAAALCLGLGIFINETTGEFPQKE-QELFEGIVAVIA 79
Cdd:TIGR00145   4 MVAVFLITLREGLEAALVVSVLLSYLKRAQRTRLRIWVWVGVLAGFAACLAIGIGVIGAYGSLQKDEfKELLEGIFGVIA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104   80 VVILTWMVFWMRKVSRNVKVQLEQAVDSALQRGNhHGWALVMMVFFAVAREGLESVFFlLAAFQQDVGVWPPLG-AMLGL 158
Cdd:TIGR00145  84 VVMLSYMGLWMLRMQRKWRVKIERQLVQALKRKR-SGWAIALIAFIAVVREGLETVLF-LAGFQQGSHATAYIGpAVAGL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104  159 ATAVVLGFLLYWGGIRLNLGAFFKWTSLFILFVAAGLAAGAIRAFHEAGLWNHFQEIAFDMSAVLSTHSLFGTLMEGIFG 238
Cdd:TIGR00145 162 IVAVVVGVLLYRGGSRLSLKIFFILSSSLLLFIAAGLLGGGNHRFNLAGGGDGFGSYNFDKAVSCCNPELDWLLFNGLLG 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 446420104  239 --YQEAPSVSEVAVWFIYLIPA---LVAFVLPPRA-GATASR 274
Cdd:TIGR00145 242 wiYYLSSSYSYNMYWLVLIIVLsllLVEEALGHRPfGKLQLK 283
 
Name Accession Description Interval E-value
TIGR00145 TIGR00145
FTR1 family protein; A characterized member from yeast acts as oxidase-coupled high affinity ...
1-274 7.05e-90

FTR1 family protein; A characterized member from yeast acts as oxidase-coupled high affinity iron transporter. Note that the apparent member from E. coli K12-MG1655 has a frameshift by homology with member sequences from other species. [Unknown function, General]


Pssm-ID: 272930  Cd Length: 283  Bit Score: 268.14  E-value: 7.05e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104    1 MFVPFLIMLREGLEAALIVSLIASYLKRTQRGRWIGVMWIGVLLAAALCLGLGIFINETTGEFPQKE-QELFEGIVAVIA 79
Cdd:TIGR00145   4 MVAVFLITLREGLEAALVVSVLLSYLKRAQRTRLRIWVWVGVLAGFAACLAIGIGVIGAYGSLQKDEfKELLEGIFGVIA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104   80 VVILTWMVFWMRKVSRNVKVQLEQAVDSALQRGNhHGWALVMMVFFAVAREGLESVFFlLAAFQQDVGVWPPLG-AMLGL 158
Cdd:TIGR00145  84 VVMLSYMGLWMLRMQRKWRVKIERQLVQALKRKR-SGWAIALIAFIAVVREGLETVLF-LAGFQQGSHATAYIGpAVAGL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104  159 ATAVVLGFLLYWGGIRLNLGAFFKWTSLFILFVAAGLAAGAIRAFHEAGLWNHFQEIAFDMSAVLSTHSLFGTLMEGIFG 238
Cdd:TIGR00145 162 IVAVVVGVLLYRGGSRLSLKIFFILSSSLLLFIAAGLLGGGNHRFNLAGGGDGFGSYNFDKAVSCCNPELDWLLFNGLLG 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 446420104  239 --YQEAPSVSEVAVWFIYLIPA---LVAFVLPPRA-GATASR 274
Cdd:TIGR00145 242 wiYYLSSSYSYNMYWLVLIIVLsllLVEEALGHRPfGKLQLK 283
FTR1 COG0672
High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism];
1-275 1.45e-84

High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism];


Pssm-ID: 440436  Cd Length: 279  Bit Score: 254.34  E-value: 1.45e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104   1 MFVPFLIMLREGLEAALIVSLIASYLKRTQRGRWIGVMWIGVLLAAALCLGLGIFINETTGEFPQKEQELFEGIVAVIAV 80
Cdd:COG0672    5 MLAAFLIVLREGLEALLVVGILLAYLRKTGRRDLLRWVWAGVGAALAASLLLAALLQYLISGLSGAGQELFEGVIGLVAV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104  81 VILTWMVFWMRKVSRNVKVQLEQAVDSALQRGNhhGWALVMMVFFAVAREGLESVFFLLAAFQQDVGVW-PPLGAMLGLA 159
Cdd:COG0672   85 AMLTWMVFWMHSKARSWKAELEGKVDAALSRGS--LWGLALLAFLAVLREGFETVLFLYALAAQAGGTSaVLLGALLGLA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104 160 TAVVLGFLLYWGGIRLNLGAFFKWTSLFILFVAAGLAAGAIRAFHEAGLWNHFQEIAFDMSAVLSTHSLFGTLMEGIFGY 239
Cdd:COG0672  163 LAVVIGYLLYRGGVRLPLRRFFRVTGVLLLLLAAGLLGKGVHELQEAGLLPALQDPLWDTSALLPDDSWPGTLLKGLLGY 242
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 446420104 240 QEAPSVSEVAVWFIYLIPALVAFVLPPRAGATASRS 275
Cdd:COG0672  243 YPRPTLEQLIAQLLYLVVVLGLFLRRARRAAAAARA 278
FTR1 pfam03239
Iron permease FTR1 family;
1-276 2.58e-72

Iron permease FTR1 family;


Pssm-ID: 251822  Cd Length: 284  Bit Score: 223.38  E-value: 2.58e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104    1 MFVPFLIMLREGLEAALIVSLIASYLKRTQRGRWIGVMWIGVLLAAALCLGLGIFINETTGEFPQ----KEQELFEGIVA 76
Cdd:pfam03239   1 MFAIFLVVLREGLEASLIVSVLLAYLKQTQRETDDLQVWAGIALAVVLALAIGQAFIGIFAGLQRdiwfIEKELFEGVLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104   77 VIAVVILTWMVFWMRKVSRNVKVQLEQAVDSALQRGNHHGWALVMMVFFAVAREGLESVFFLLAAFQQDVGV--WPPLGA 154
Cdd:pfam03239  81 YIAVVVISWMIFWMRRVGKKLKGEIEQKLAKALAMIGGLGWALFILVFITVLREGLEAVLFVAAIVAYTVKRasAYPLGV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104  155 MLGLATAVVLGFLLYWGGIRLNLGAFFKWTSLFILFVAAGLAAGAIRAFHEAGLW-NHFQEIAFDMSAVLSTHSLFGTLM 233
Cdd:pfam03239 161 VLGAATAVVLGVLIYRGGIKLNLQSFFILTSFLLLFVAAGLFAYGTHELLEKAEAcNGLDYIEFGKSASLLDGSLIGLLH 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 446420104  234 EGIFGYQEAP-SVSEVAVWFIYLIPALVAFVLPPRAGATASRSV 276
Cdd:pfam03239 241 HAFLAVQREGeILLALLGYFNTAYWLRVAIQLGLLLIKLGSRLP 284
 
Name Accession Description Interval E-value
TIGR00145 TIGR00145
FTR1 family protein; A characterized member from yeast acts as oxidase-coupled high affinity ...
1-274 7.05e-90

FTR1 family protein; A characterized member from yeast acts as oxidase-coupled high affinity iron transporter. Note that the apparent member from E. coli K12-MG1655 has a frameshift by homology with member sequences from other species. [Unknown function, General]


Pssm-ID: 272930  Cd Length: 283  Bit Score: 268.14  E-value: 7.05e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104    1 MFVPFLIMLREGLEAALIVSLIASYLKRTQRGRWIGVMWIGVLLAAALCLGLGIFINETTGEFPQKE-QELFEGIVAVIA 79
Cdd:TIGR00145   4 MVAVFLITLREGLEAALVVSVLLSYLKRAQRTRLRIWVWVGVLAGFAACLAIGIGVIGAYGSLQKDEfKELLEGIFGVIA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104   80 VVILTWMVFWMRKVSRNVKVQLEQAVDSALQRGNhHGWALVMMVFFAVAREGLESVFFlLAAFQQDVGVWPPLG-AMLGL 158
Cdd:TIGR00145  84 VVMLSYMGLWMLRMQRKWRVKIERQLVQALKRKR-SGWAIALIAFIAVVREGLETVLF-LAGFQQGSHATAYIGpAVAGL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104  159 ATAVVLGFLLYWGGIRLNLGAFFKWTSLFILFVAAGLAAGAIRAFHEAGLWNHFQEIAFDMSAVLSTHSLFGTLMEGIFG 238
Cdd:TIGR00145 162 IVAVVVGVLLYRGGSRLSLKIFFILSSSLLLFIAAGLLGGGNHRFNLAGGGDGFGSYNFDKAVSCCNPELDWLLFNGLLG 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 446420104  239 --YQEAPSVSEVAVWFIYLIPA---LVAFVLPPRA-GATASR 274
Cdd:TIGR00145 242 wiYYLSSSYSYNMYWLVLIIVLsllLVEEALGHRPfGKLQLK 283
FTR1 COG0672
High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism];
1-275 1.45e-84

High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism];


Pssm-ID: 440436  Cd Length: 279  Bit Score: 254.34  E-value: 1.45e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104   1 MFVPFLIMLREGLEAALIVSLIASYLKRTQRGRWIGVMWIGVLLAAALCLGLGIFINETTGEFPQKEQELFEGIVAVIAV 80
Cdd:COG0672    5 MLAAFLIVLREGLEALLVVGILLAYLRKTGRRDLLRWVWAGVGAALAASLLLAALLQYLISGLSGAGQELFEGVIGLVAV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104  81 VILTWMVFWMRKVSRNVKVQLEQAVDSALQRGNhhGWALVMMVFFAVAREGLESVFFLLAAFQQDVGVW-PPLGAMLGLA 159
Cdd:COG0672   85 AMLTWMVFWMHSKARSWKAELEGKVDAALSRGS--LWGLALLAFLAVLREGFETVLFLYALAAQAGGTSaVLLGALLGLA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104 160 TAVVLGFLLYWGGIRLNLGAFFKWTSLFILFVAAGLAAGAIRAFHEAGLWNHFQEIAFDMSAVLSTHSLFGTLMEGIFGY 239
Cdd:COG0672  163 LAVVIGYLLYRGGVRLPLRRFFRVTGVLLLLLAAGLLGKGVHELQEAGLLPALQDPLWDTSALLPDDSWPGTLLKGLLGY 242
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 446420104 240 QEAPSVSEVAVWFIYLIPALVAFVLPPRAGATASRS 275
Cdd:COG0672  243 YPRPTLEQLIAQLLYLVVVLGLFLRRARRAAAAARA 278
FTR1 pfam03239
Iron permease FTR1 family;
1-276 2.58e-72

Iron permease FTR1 family;


Pssm-ID: 251822  Cd Length: 284  Bit Score: 223.38  E-value: 2.58e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104    1 MFVPFLIMLREGLEAALIVSLIASYLKRTQRGRWIGVMWIGVLLAAALCLGLGIFINETTGEFPQ----KEQELFEGIVA 76
Cdd:pfam03239   1 MFAIFLVVLREGLEASLIVSVLLAYLKQTQRETDDLQVWAGIALAVVLALAIGQAFIGIFAGLQRdiwfIEKELFEGVLS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104   77 VIAVVILTWMVFWMRKVSRNVKVQLEQAVDSALQRGNHHGWALVMMVFFAVAREGLESVFFLLAAFQQDVGV--WPPLGA 154
Cdd:pfam03239  81 YIAVVVISWMIFWMRRVGKKLKGEIEQKLAKALAMIGGLGWALFILVFITVLREGLEAVLFVAAIVAYTVKRasAYPLGV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420104  155 MLGLATAVVLGFLLYWGGIRLNLGAFFKWTSLFILFVAAGLAAGAIRAFHEAGLW-NHFQEIAFDMSAVLSTHSLFGTLM 233
Cdd:pfam03239 161 VLGAATAVVLGVLIYRGGIKLNLQSFFILTSFLLLFVAAGLFAYGTHELLEKAEAcNGLDYIEFGKSASLLDGSLIGLLH 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 446420104  234 EGIFGYQEAP-SVSEVAVWFIYLIPALVAFVLPPRAGATASRSV 276
Cdd:pfam03239 241 HAFLAVQREGeILLALLGYFNTAYWLRVAIQLGLLLIKLGSRLP 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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