NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446420426|ref|WP_000498281|]
View 

MULTISPECIES: alpha/beta fold hydrolase [Bacillus]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 1-269 1.04e-51

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 168.26  E-value: 1.04e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426   1 MFVTVEkDVHIFVQDVnpGPGSKTVFFVHGWPLNHQMYQYQLNVLPEHgFRCIAMDIRGNGQSDKPWTGYTYDRLADDIA 80
Cdd:COG0596    5 RFVTVD-GVRLHYREA--GPDGPPVVLLHGLPGSSYEWRPLIPALAAG-YRVIAPDLRGHGRSDKPAGGYTLDDLADDLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  81 IVLEALQVENATLVGFSVGGALSIRYMSRYnGRRISKLALIDAVSPSFVKNQESPYGVPKeqadtlihqmyvnlpkflsd 160
Cdd:COG0596   81 ALLDALGLERVVLVGHSMGGMVALELAARH-PERVAGLVLVDEVLAALAEPLRRPGLAPE-------------------- 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426 161 vslsffnrnlgaatlewfsylgmqsasyALIKILQAAANEDVTKDLSKINVPTKIFHGVHDQLIPYKSAELTQKRIKNAQ 240
Cdd:COG0596  140 ----------------------------ALAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAE 191

                        250       260
                 ....*....|....*....|....*....
gi 446420426 241 LHALTNSGHGSPIDQADELNAELIKFLNS 269
Cdd:COG0596  192 LVVLPGAGHFPPLEQPEAFAAALRDFLAR 220
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 1-269 1.04e-51

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 168.26  E-value: 1.04e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426   1 MFVTVEkDVHIFVQDVnpGPGSKTVFFVHGWPLNHQMYQYQLNVLPEHgFRCIAMDIRGNGQSDKPWTGYTYDRLADDIA 80
Cdd:COG0596    5 RFVTVD-GVRLHYREA--GPDGPPVVLLHGLPGSSYEWRPLIPALAAG-YRVIAPDLRGHGRSDKPAGGYTLDDLADDLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  81 IVLEALQVENATLVGFSVGGALSIRYMSRYnGRRISKLALIDAVSPSFVKNQESPYGVPKeqadtlihqmyvnlpkflsd 160
Cdd:COG0596   81 ALLDALGLERVVLVGHSMGGMVALELAARH-PERVAGLVLVDEVLAALAEPLRRPGLAPE-------------------- 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426 161 vslsffnrnlgaatlewfsylgmqsasyALIKILQAAANEDVTKDLSKINVPTKIFHGVHDQLIPYKSAELTQKRIKNAQ 240
Cdd:COG0596  140 ----------------------------ALAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAE 191

                        250       260
                 ....*....|....*....|....*....
gi 446420426 241 LHALTNSGHGSPIDQADELNAELIKFLNS 269
Cdd:COG0596  192 LVVLPGAGHFPPLEQPEAFAAALRDFLAR 220
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 23-254 1.44e-30

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 114.14  E-value: 1.44e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426   23 KTVFFVHGWPLNHQMYQYQLNVLPEHGFRCIAMDIRGNGQSDKP--WTGYTYDRLADDIAIVLEALQVENATLVGFSVGG 100
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRPkaQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  101 ALSIRYMSRYNgRRISKLALIDAVSPSFVKNQESPYGVPK--EQADTLI-------HQMYVNLPKFLSDVSLSFFNR--- 168
Cdd:pfam00561  81 LIALAYAAKYP-DRVKALVLLGALDPPHELDEADRFILALfpGFFDGFVadfapnpLGRLVAKLLALLLLRLRLLKAlpl 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  169 -NLGAATLEW--FSYLGMQSASYalikiLQAAANEDVTKDLSKINVPTKIFHGVHDQLIPYKSAELTQKRIKNAQLHALT 245
Cdd:pfam00561 160 lNKRFPSGDYalAKSLVTGALLF-----IETWSTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIP 234


                  ....*....
gi 446420426  246 NSGHGSPID 254
Cdd:pfam00561 235 DAGHFAFLE 243
PRK05855 PRK05855
SDR family oxidoreductase;
1-87 3.81e-13

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 68.85  E-value: 3.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426   1 MFVTVEKDVHIFVQDVNPgPGSKTVFFVHGWPLNHQMYQYQLNVLPEHgFRCIAMDIRGNGQSDKP-WT-GYTYDRLADD 78
Cdd:PRK05855   5 RTVVSSDGVRLAVYEWGD-PDRPTVVLVHGYPDNHEVWDGVAPLLADR-FRVVAYDVRGAGRSSAPkRTaAYTLARLADD 82


                 ....*....
gi 446420426  79 IAIVLEALQ 87
Cdd:PRK05855  83 FAAVIDAVS 91
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 1-269 1.04e-51

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 168.26  E-value: 1.04e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426   1 MFVTVEkDVHIFVQDVnpGPGSKTVFFVHGWPLNHQMYQYQLNVLPEHgFRCIAMDIRGNGQSDKPWTGYTYDRLADDIA 80
Cdd:COG0596    5 RFVTVD-GVRLHYREA--GPDGPPVVLLHGLPGSSYEWRPLIPALAAG-YRVIAPDLRGHGRSDKPAGGYTLDDLADDLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  81 IVLEALQVENATLVGFSVGGALSIRYMSRYnGRRISKLALIDAVSPSFVKNQESPYGVPKeqadtlihqmyvnlpkflsd 160
Cdd:COG0596   81 ALLDALGLERVVLVGHSMGGMVALELAARH-PERVAGLVLVDEVLAALAEPLRRPGLAPE-------------------- 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426 161 vslsffnrnlgaatlewfsylgmqsasyALIKILQAAANEDVTKDLSKINVPTKIFHGVHDQLIPYKSAELTQKRIKNAQ 240
Cdd:COG0596  140 ----------------------------ALAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAE 191

                        250       260
                 ....*....|....*....|....*....
gi 446420426 241 LHALTNSGHGSPIDQADELNAELIKFLNS 269
Cdd:COG0596  192 LVVLPGAGHFPPLEQPEAFAAALRDFLAR 220
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 23-254 1.44e-30

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 114.14  E-value: 1.44e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426   23 KTVFFVHGWPLNHQMYQYQLNVLPEHGFRCIAMDIRGNGQSDKP--WTGYTYDRLADDIAIVLEALQVENATLVGFSVGG 100
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRPkaQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  101 ALSIRYMSRYNgRRISKLALIDAVSPSFVKNQESPYGVPK--EQADTLI-------HQMYVNLPKFLSDVSLSFFNR--- 168
Cdd:pfam00561  81 LIALAYAAKYP-DRVKALVLLGALDPPHELDEADRFILALfpGFFDGFVadfapnpLGRLVAKLLALLLLRLRLLKAlpl 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  169 -NLGAATLEW--FSYLGMQSASYalikiLQAAANEDVTKDLSKINVPTKIFHGVHDQLIPYKSAELTQKRIKNAQLHALT 245
Cdd:pfam00561 160 lNKRFPSGDYalAKSLVTGALLF-----IETWSTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIP 234


                  ....*....
gi 446420426  246 NSGHGSPID 254
Cdd:pfam00561 235 DAGHFAFLE 243
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
2-269 3.56e-22

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 91.60  E-value: 3.56e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426   2 FVTVEKDVHIFVQDVNPGPGSK-TVFFVHGWPLNHQMYQYQLNVLPEHGFRCIAMDIRGNGQSDKPwTGY--TYDRLADD 78
Cdd:COG2267    7 TLPTRDGLRLRGRRWRPAGSPRgTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGP-RGHvdSFDDYVDD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  79 IAIVLEALQVENAT---LVGFSVGGALSIRYMSRYnGRRISKLALIDavspsfvknqespygvPKEQADTLIHqmyvnlp 155
Cdd:COG2267   86 LRAALDALRARPGLpvvLLGHSMGGLIALLYAARY-PDRVAGLVLLA----------------PAYRADPLLG------- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426 156 kflsdvslsffnrnlgaATLEWFSYLgmqsasyalikilqaaaneDVTKDLSKINVPTKIFHGVHDQLIPYKSAELTQKR 235
Cdd:COG2267  142 -----------------PSARWLRAL-------------------RLAEALARIDVPVLVLHGGADRVVPPEAARRLAAR 185

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 446420426 236 I-KNAQLHALTNSGHGSPIDQA-DELNAELIKFLNS 269
Cdd:COG2267  186 LsPDVELVLLPGARHELLNEPArEEVLAAILAWLER 221
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
21-269 2.58e-20

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 86.92  E-value: 2.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  21 GSKTVFFVHG--------WPLNHQMYqyqlnvlpEHGFRCIAMDIRGNGQSDKPWTGYTYDRLADDIAIVLEALQ--VEN 90
Cdd:COG1647   14 GRKGVLLLHGftgspaemRPLAEALA--------KAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILKagYDK 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  91 ATLVGFSVGGALSIRYMSRYNgrRISKLALIdavSPSFVKNQESPYGVPkeqadtLIHQMYVNLPKFLSDVslsffnrNL 170
Cdd:COG1647   86 VIVIGLSMGGLLALLLAARYP--DVAGLVLL---SPALKIDDPSAPLLP------LLKYLARSLRGIGSDI-------ED 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426 171 GAATLEWFSYLGMQSAsYALIKILqaaanEDVTKDLSKINVPTKIFHGVHDQLIPYKSAELTQKRI--KNAQLHALTNSG 248
Cdd:COG1647  148 PEVAEYAYDRTPLRAL-AELQRLI-----REVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLgsPDKELVWLEDSG 221

                        250       260
                 ....*....|....*....|..
gi 446420426 249 HGSPID-QADELNAELIKFLNS 269
Cdd:COG1647  222 HVITLDkDREEVAEEILDFLER 243
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 25-262 3.69e-15

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 72.12  E-value: 3.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426   25 VFFVHGWPLNHQmyqyQLNVLPEHGFRCIAMDIRGNGQSDKPWtgYTYDRLADDIAIVLEALQVENATLVGFSVGGALSI 104
Cdd:pfam12697   1 VVLVHGAGLSAA----PLAALLAAGVAVLAPDLPGHGSSSPPP--LDLADLADLAALLDELGAARPVVLVGHSLGGAVAL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  105 RYMSRYNGRRIsklaLIDAVSpsfvknqespygvpkeqADTLIHQMYVNLPKFLSDVSLSFFNRNLGAATLEWFSYLGMQ 184
Cdd:pfam12697  75 AAAAAALVVGV----LVAPLA-----------------APPGLLAALLALLARLGAALAAPAWLAAESLARGFLDDLPAD 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  185 SASYALIKILQAAAN---EDVTKDLSKINVPTKIFHGvHDQLIPYKSAELTQKRIKnAQLHALTNSGHgSPIDQADELNA 261
Cdd:pfam12697 134 AEWAAALARLAALLAalaLLPLAAWRDLPVPVLVLAE-EDRLVPELAQRLLAALAG-ARLVVLPGAGH-LPLDDPEEVAE 210


                  .
gi 446420426  262 E 262
Cdd:pfam12697 211 A 211
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 23-242 8.17e-14

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 68.78  E-value: 8.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426   23 KTVFFVHGwpLN-H-QMYQYQLNVLPEHGFRCIAMDIRGNGQSDkPWTGY--TYDRLADDIAIVLEALQVENAT----LV 94
Cdd:pfam12146   5 AVVVLVHG--LGeHsGRYAHLADALAAQGFAVYAYDHRGHGRSD-GKRGHvpSFDDYVDDLDTFVDKIREEHPGlplfLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426   95 GFSVGGALSIRYMSRYnGRRISKLALidaVSPSFVKNQESPYGVPKEQADTLIH---QMYVNLPKFLSDVSlsffnRNlg 171
Cdd:pfam12146  82 GHSMGGLIAALYALRY-PDKVDGLIL---SAPALKIKPYLAPPILKLLAKLLGKlfpRLRVPNNLLPDSLS-----RD-- 150

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446420426  172 AATLEWFS----YLGMQSASYALiKILQAAanEDVTKDLSKINVPTKIFHGVHDQLIPYKSAELTQKRI--KNAQLH 242
Cdd:pfam12146 151 PEVVAAYAadplVHGGISARTLY-ELLDAG--ERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAgsTDKTLK 224
PRK05855 PRK05855
SDR family oxidoreductase;
1-87 3.81e-13

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 68.85  E-value: 3.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426   1 MFVTVEKDVHIFVQDVNPgPGSKTVFFVHGWPLNHQMYQYQLNVLPEHgFRCIAMDIRGNGQSDKP-WT-GYTYDRLADD 78
Cdd:PRK05855   5 RTVVSSDGVRLAVYEWGD-PDRPTVVLVHGYPDNHEVWDGVAPLLADR-FRVVAYDVRGAGRSSAPkRTaAYTLARLADD 82


                 ....*....
gi 446420426  79 IAIVLEALQ 87
Cdd:PRK05855  83 FAAVIDAVS 91
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 19-267 5.79e-13

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 68.05  E-value: 5.79e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  19 GPGSKT-VFFVHG-------WPLNHQmyqyqlnVLPEHgFRCIAMDIRGNGQSDKPWTGYTYDRLADDIAIVLEALQVEN 90
Cdd:PRK14875 127 GEGDGTpVVLIHGfggdlnnWLFNHA-------ALAAG-RPVIALDLPGHGASSKAVGAGSLDELAAAVLAFLDALGIER 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  91 ATLVGFSVGGALSIRYMSRYNGrRISKLALIdavspsfvknqeSPYGVPKEQADTLIH---------QMYVNLPKFLSDV 161
Cdd:PRK14875 199 AHLVGHSMGGAVALRLAARAPQ-RVASLTLI------------APAGLGPEINGDYIDgfvaaesrrELKPVLELLFADP 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426 162 SLsfFNRNLGAATLEwfsYLGMQSASYALIKILQAAA-----NEDVTKDLSKINVPTKIFHGVHDQLIPYKSAELTQkri 236
Cdd:PRK14875 266 AL--VTRQMVEDLLK---YKRLDGVDDALRALADALFaggrqRVDLRDRLASLAIPVLVIWGEQDRIIPAAHAQGLP--- 337

                        250       260       270
                 ....*....|....*....|....*....|.
gi 446420426 237 KNAQLHALTNSGHGSPIDQADELNAELIKFL 267
Cdd:PRK14875 338 DGVAVHVLPGAGHMPQMEAAADVNRLLAEFL 368
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
24-268 2.86e-12

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 64.65  E-value: 2.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  24 TVFFVHGWPLN-HQMYQYQLNVLPEHGFRCIAMDIRGNGQSDKPWTGYTYDRLADDIAIVLEALQV--ENATLVGFSVGG 100
Cdd:COG1506   25 VVVYVHGGPGSrDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVDDVLAAIDYLAARPYVdpDRIGIYGHSYGG 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426 101 ALSIRYMSRYNgRRISKLALIDAVSpsfvknqespygvpkeqadtlihqmyvnlpkflsdvSLSFFNRNLGAATLEWFSY 180
Cdd:COG1506  105 YMALLAAARHP-DRFKAAVALAGVS------------------------------------DLRSYYGTTREYTERLMGG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426 181 LGMQSASYALIKILQAAAnedvtkdlsKINVPTKIFHGVHDQLIPYKSAELT----QKRIKNAQLHALTNSGHGSPIDQA 256
Cdd:COG1506  148 PWEDPEAYAARSPLAYAD---------KLKTPLLLIHGEADDRVPPEQAERLyealKKAGKPVELLVYPGEGHGFSGAGA 218

                        250
                 ....*....|..
gi 446420426 257 DELNAELIKFLN 268
Cdd:COG1506  219 PDYLERILDFLD 230
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 25-124 3.54e-12

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 65.02  E-value: 3.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  25 VFFVHGWPLNHQMYQyqlNVLP---EHGfRCIAMDIRGNGQSDKPWTGYTYDRLADDIAIVLEALQVENATLVGFSVGGA 101
Cdd:PRK03592  30 IVFLHGNPTSSYLWR---NIIPhlaGLG-RCLAPDLIGMGASDKPDIDYTFADHARYLDAWFDALGLDDVVLVGHDWGSA 105

                         90       100
                 ....*....|....*....|...
gi 446420426 102 LSIRYMSRYNGrRISKLALIDAV 124
Cdd:PRK03592 106 LGFDWAARHPD-RVRGIAFMEAI 127
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 17-268 7.36e-10

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 58.00  E-value: 7.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  17 NPGPGSKTVFFVHGWPLNHQMYQYQLNVLPEHGFRCIAMDIRGNGQSDKPWTGY-TYDRLadDI--AI--VLEALQVENA 91
Cdd:COG1073   32 GASKKYPAVVVAHGNGGVKEQRALYAQRLAELGFNVLAFDYRGYGESEGEPREEgSPERR--DAraAVdyLRTLPGVDPE 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  92 TLV--GFSVGGALSIRYMSRYngRRISKLALidavspsfvknqESPYGVPKEQADTLIHQMYvnlpkflsdvslsffnrn 169
Cdd:COG1073  110 RIGllGISLGGGYALNAAATD--PRVKAVIL------------DSPFTSLEDLAAQRAKEAR------------------ 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426 170 lgAATLEWFSYLgmqsasyALIKILQAAANE-DVTKDLSKINVPTKIFHGVHDQLIPYKSAELTQKRIKNA-QLHALTNS 247
Cdd:COG1073  158 --GAYLPGVPYL-------PNVRLASLLNDEfDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPkELLIVPGA 228

                        250       260
                 ....*....|....*....|..
gi 446420426 248 GHGSPIDQADELN-AELIKFLN 268
Cdd:COG1073  229 GHVDLYDRPEEEYfDKLAEFFK 250
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 15-105 4.00e-08

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 53.05  E-value: 4.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  15 DVNPGPGsKTVFFVHGWPLNHQMYQYQLNVLPEHGFRCIAMDIRGNGQSDKPW--TGYTYDRLADDIAIVLEALQVENAT 92
Cdd:PRK00870  40 DEGPADG-PPVLLLHGEPSWSYLYRKMIPILAAAGHRVIAPDLIGFGRSDKPTrrEDYTYARHVEWMRSWFEQLDLTDVT 118

                         90
                 ....*....|...
gi 446420426  93 LVGFSVGGALSIR 105
Cdd:PRK00870 119 LVCQDWGGLIGLR 131
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 20-259 7.85e-07

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 49.49  E-value: 7.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  20 PGSKTVFFVHGWPlnHQMYQYQlNVLP--EHGFRCIAMDIRGNGQSDKPWTGYTYDRLADDIAIVLEALQVENAT-LVGF 96
Cdd:PLN03084 125 NNNPPVLLIHGFP--SQAYSYR-KVLPvlSKNYHAIAFDWLGFGFSDKPQPGYGFNYTLDEYVSSLESLIDELKSdKVSL 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  97 SVGGALS---IRYMSRyNGRRISKLALIDavsPSFVKNQESPYGVPKEQADTLIHQMYVNLPKFLSD---VSLSFFNRNL 170
Cdd:PLN03084 202 VVQGYFSppvVKYASA-HPDKIKKLILLN---PPLTKEHAKLPSTLSEFSNFLLGEIFSQDPLRASDkalTSCGPYAMKE 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426 171 GAATLEWFSYLGMQSASYALIKILQAAANE------DVTKDLSKIN--VPTKIFHGVHDQLIPYKSAELTQKRiKNAQLH 242
Cdd:PLN03084 278 DDAMVYRRPYLTSGSSGFALNAISRSMKKElkkyieEMRSILTDKNwkTPITVCWGLRDRWLNYDGVEDFCKS-SQHKLI 356

                        250
                 ....*....|....*..
gi 446420426 243 ALTNSGHGSPIDQADEL 259
Cdd:PLN03084 357 ELPMAGHHVQEDCGEEL 373
PRK03204 PRK03204
haloalkane dehalogenase; Provisional
 15-104 5.37e-05

haloalkane dehalogenase; Provisional


Pssm-ID: 179554 [Multi-domain]  Cd Length: 286  Bit Score: 43.69  E-value: 5.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  15 DVNPGPgskTVFFVHGWPLNHQMYQYQLNVLPEHgFRCIAMDIRGNGQSDKPWT-GYTYDRLADDIAIVLEALQVENATL 93
Cdd:PRK03204  30 DEGTGP---PILLCHGNPTWSFLYRDIIVALRDR-FRCVAPDYLGFGLSERPSGfGYQIDEHARVIGEFVDHLGLDRYLS 105

                         90
                 ....*....|.
gi 446420426  94 VGFSVGGALSI 104
Cdd:PRK03204 106 MGQDWGGPISM 116
PRK10673 PRK10673
esterase;
53-122 9.80e-05

esterase;


Pssm-ID: 182637 [Multi-domain]  Cd Length: 255  Bit Score: 42.79  E-value: 9.80e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446420426  53 IAMDIRGNGQSdkPWT-GYTYDRLADDIAIVLEALQVENATLVGFSVGGALSIRyMSRYNGRRISKLALID 122
Cdd:PRK10673  46 IQVDMRNHGLS--PRDpVMNYPAMAQDLLDTLDALQIEKATFIGHSMGGKAVMA-LTALAPDRIDKLVAID 113
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
18-110 3.32e-04

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 41.11  E-value: 3.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  18 PGPGsktVFFVHGWPLNHQMYQYQLNVLPEHGFRCIAMDIRGNG-------QSDKPWTGYTYDRLADDIAIVLEALQVEN 90
Cdd:COG0412   28 PRPG---VVVLHEIFGLNPHIRDVARRLAAAGYVVLAPDLYGRGgpgddpdEARALMGALDPELLAADLRAALDWLKAQP 104

                         90       100
                 ....*....|....*....|....*.
gi 446420426  91 AT------LVGFSVGGALSIRYMSRY 110
Cdd:COG0412  105 EVdagrvgVVGFCFGGGLALLAAARG 130
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 20-110 3.71e-03

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 38.35  E-value: 3.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  20 PGSKTVFFVHGWPLNHQMYQYQLNVLPEHgFRCIAMDIRGNGQSDKP-----WTGYTYDRLADDIAIVLEALQVENATLV 94
Cdd:PLN02894 103 EDAPTLVMVHGYGASQGFFFRNFDALASR-FRVIAIDQLGWGGSSRPdftckSTEETEAWFIDSFEEWRKAKNLSNFILL 181

                         90
                 ....*....|....*.
gi 446420426  95 GFSVGGALSIRYMSRY 110
Cdd:PLN02894 182 GHSFGGYVAAKYALKH 197
YpfH COG0400
Predicted esterase [General function prediction only];
18-121 8.14e-03

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 36.42  E-value: 8.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420426  18 PGPGSKTVFFVHGW--------PLNHQmyqyqlnvLPEHGFRCIA--------------MDIRG-NGQSDKPWTGYTYDR 74
Cdd:COG0400    1 GGPAAPLVVLLHGYggdeedllPLAPE--------LALPGAAVLAprapvpegpggrawFDLSFlEGREDEEGLAAAAEA 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 446420426  75 LADDIAIVLEALQV--ENATLVGFSVGGALSIRYMSRYnGRRISKLALI 121
Cdd:COG0400   73 LAAFIDELEARYGIdpERIVLAGFSQGAAMALSLALRR-PELLAGVVAL 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH