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Conserved domains on  [gi|446421260|ref|WP_000499115|]
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MULTISPECIES: hypothetical protein [Enterobacteriaceae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VPA1262_N_dom super family cl46212
VPA1262 family N-terminal domain; The founding member VPA1262, of this domain family is a ...
 121-246 8.65e-04

VPA1262 family N-terminal domain; The founding member VPA1262, of this domain family is a large protein of 1104 amino acids, found in a pathogenicity island of Vibrio parahaemolyticus RIMD 2210633. Many homologs of half that length share homology only to the N-terminal half. Members of the family share well-conserved DP[FY] and HDR motifs. The related model NF040699 describes full-length homologs of VPA1262. The function is unknown.


The actual alignment was detected with superfamily member NF040700:

Pssm-ID: 480552  Cd Length: 475  Bit Score: 40.45  E-value: 8.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446421260 121 DDFFGLNYARQKIVAriAEDMISIISRllKTSEHIIIVDPYFSDKQrwwnvFISLLSVSANNsykkNLKIDVIF------ 194
Cdd:NF040700 309 GRFFQRGWGDGRLEA--LEWIRKLINQ--AGSKGVIIVDPYFEAVD-----LLQLLFRLSRS----DVDLTILTslkafd 375

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446421260 195 -DGSKENSPTVNYLANKLN--RENLVFPddfKLSVTFKSLTSREGNEcLHNRYVL 246
Cdd:NF040700 376 pDDKDGTNPSRDRIQRLLAalEELKNKQ---LLHLELRVLNLPRGWA-FHDRFLL 426
 
Name Accession Description Interval E-value
VPA1262_N_dom NF040700
VPA1262 family N-terminal domain; The founding member VPA1262, of this domain family is a ...
 121-246 8.65e-04

VPA1262 family N-terminal domain; The founding member VPA1262, of this domain family is a large protein of 1104 amino acids, found in a pathogenicity island of Vibrio parahaemolyticus RIMD 2210633. Many homologs of half that length share homology only to the N-terminal half. Members of the family share well-conserved DP[FY] and HDR motifs. The related model NF040699 describes full-length homologs of VPA1262. The function is unknown.


Pssm-ID: 468664  Cd Length: 475  Bit Score: 40.45  E-value: 8.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446421260 121 DDFFGLNYARQKIVAriAEDMISIISRllKTSEHIIIVDPYFSDKQrwwnvFISLLSVSANNsykkNLKIDVIF------ 194
Cdd:NF040700 309 GRFFQRGWGDGRLEA--LEWIRKLINQ--AGSKGVIIVDPYFEAVD-----LLQLLFRLSRS----DVDLTILTslkafd 375

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446421260 195 -DGSKENSPTVNYLANKLN--RENLVFPddfKLSVTFKSLTSREGNEcLHNRYVL 246
Cdd:NF040700 376 pDDKDGTNPSRDRIQRLLAalEELKNKQ---LLHLELRVLNLPRGWA-FHDRFLL 426
 
Name Accession Description Interval E-value
VPA1262_N_dom NF040700
VPA1262 family N-terminal domain; The founding member VPA1262, of this domain family is a ...
 121-246 8.65e-04

VPA1262 family N-terminal domain; The founding member VPA1262, of this domain family is a large protein of 1104 amino acids, found in a pathogenicity island of Vibrio parahaemolyticus RIMD 2210633. Many homologs of half that length share homology only to the N-terminal half. Members of the family share well-conserved DP[FY] and HDR motifs. The related model NF040699 describes full-length homologs of VPA1262. The function is unknown.


Pssm-ID: 468664  Cd Length: 475  Bit Score: 40.45  E-value: 8.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446421260 121 DDFFGLNYARQKIVAriAEDMISIISRllKTSEHIIIVDPYFSDKQrwwnvFISLLSVSANNsykkNLKIDVIF------ 194
Cdd:NF040700 309 GRFFQRGWGDGRLEA--LEWIRKLINQ--AGSKGVIIVDPYFEAVD-----LLQLLFRLSRS----DVDLTILTslkafd 375

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446421260 195 -DGSKENSPTVNYLANKLN--RENLVFPddfKLSVTFKSLTSREGNEcLHNRYVL 246
Cdd:NF040700 376 pDDKDGTNPSRDRIQRLLAalEELKNKQ---LLHLELRVLNLPRGWA-FHDRFLL 426
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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