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Conserved domains on  [gi|446422457|ref|WP_000500312|]
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MULTISPECIES: response regulator [Bacillus cereus group]

Protein Classification

response regulator( domain architecture ID 10361425)

response regulator containing a DNA-binding YcbB domain, receives the signal from the sensor partner in a two-component system

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YcbB pfam08664
YcbB domain; YcbB is a DNA-binding domain.
 159-299 7.59e-66

YcbB domain; YcbB is a DNA-binding domain.


:

Pssm-ID: 462553  Cd Length: 136  Bit Score: 202.83  E-value: 7.59e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457  159 SGRFLLSELGIAGENGSKDLLSMLEYLYGQEKAQTFEFGFPALKDIFHQIIVKKLgelASDADIEKERKASEQRVRRAIY 238
Cdd:pfam08664   1 KGQFILSELGIIGESGSKDLLDIVEWLIEQEKEGLSEKSFPSLKDIYEELASKKE---SSDEDIEKEIKAIEQRIRRAIK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446422457  239 QSLNHLASLGLTDFSNPKFESYAPKFFDFTVVRKRMTEMTKDEvaTSGHIRINTKKFIQVL 299
Cdd:pfam08664  78 QALTHLASLGLTDYSNPKFEEYASKLFDFTEVRKEMKELRGKS--SSSKGRINVKKFIEGL 136
REC super family cl19078
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 3-105 1.36e-38

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


The actual alignment was detected with superfamily member cd17565:

Pssm-ID: 473134 [Multi-domain]  Cd Length: 103  Bit Score: 132.01  E-value: 1.36e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   3 YYIVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAfIEAEQLNYKKVDILFIDLLMPMRDGIETVRHI-ASSFTGKIIMIS 81
Cdd:cd17565    1 FYIVDDDKNIIKILSDIIEDDDLGEVVGEADNGA-QAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLkDTGSNGKFIMIS 79

                         90       100
                 ....*....|....*....|....
gi 446422457  82 QVESKQLIGEAYTLGVEYYITKPL 105
Cdd:cd17565   80 QVSDKEMIGKAYQAGIEFFINKPI 103
 
Name Accession Description Interval E-value
YcbB pfam08664
YcbB domain; YcbB is a DNA-binding domain.
 159-299 7.59e-66

YcbB domain; YcbB is a DNA-binding domain.


Pssm-ID: 462553  Cd Length: 136  Bit Score: 202.83  E-value: 7.59e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457  159 SGRFLLSELGIAGENGSKDLLSMLEYLYGQEKAQTFEFGFPALKDIFHQIIVKKLgelASDADIEKERKASEQRVRRAIY 238
Cdd:pfam08664   1 KGQFILSELGIIGESGSKDLLDIVEWLIEQEKEGLSEKSFPSLKDIYEELASKKE---SSDEDIEKEIKAIEQRIRRAIK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446422457  239 QSLNHLASLGLTDFSNPKFESYAPKFFDFTVVRKRMTEMTKDEvaTSGHIRINTKKFIQVL 299
Cdd:pfam08664  78 QALTHLASLGLTDYSNPKFEEYASKLFDFTEVRKEMKELRGKS--SSSKGRINVKKFIEGL 136
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 3-105 1.36e-38

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 132.01  E-value: 1.36e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   3 YYIVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAfIEAEQLNYKKVDILFIDLLMPMRDGIETVRHI-ASSFTGKIIMIS 81
Cdd:cd17565    1 FYIVDDDKNIIKILSDIIEDDDLGEVVGEADNGA-QAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLkDTGSNGKFIMIS 79

                         90       100
                 ....*....|....*....|....
gi 446422457  82 QVESKQLIGEAYTLGVEYYITKPL 105
Cdd:cd17565   80 QVSDKEMIGKAYQAGIEFFINKPI 103
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 4-104 3.19e-22

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 89.06  E-value: 3.19e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   4 YIVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHI-ASSFTGKIIMIS 81
Cdd:COG4753    3 LIVDDEPLIREGLKRILEWEAGFEVVGEAENGE--EAlELLEEHKPDLVITDINMPGMDGLELLEAIrELDPDTKIIILS 80

                         90       100
                 ....*....|....*....|...
gi 446422457  82 QVESKQLIGEAYTLGVEYYITKP 104
Cdd:COG4753   81 GYSDFEYAQEAIKLGADDYLLKP 103
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 5-115 1.57e-17

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 76.81  E-value: 1.57e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457    5 IVDDDEVFRSMLSQIIEDgdLGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHI-ASSFTGKIIMISQ 82
Cdd:pfam00072   3 IVDDDPLIRELLRQLLEK--EGYVVAEADDGK--EAlELLKEERPDLILLDINMPGMDGLELLKRIrRRDPTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 446422457   83 VESKQLIGEAYTLGVEYYITKPLNKIEVVSVVR 115
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
5-122 1.93e-10

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 60.93  E-value: 1.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIE-DGDLgEVIGESEDGafIEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGKIIMISQ 82
Cdd:PRK00742   8 VVDDSAFMRRLISEILNsDPDI-EVVGTAPDG--LEArEKIKKLNPDVITLDVEMPVMDGLDALEKIMRLRPTPVVMVSS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 446422457  83 V--ESKQLIGEAYTLGVEYYITKP-----LNKIEvvsVVRKVIERIR 122
Cdd:PRK00742  85 LteRGAEITLRALELGAVDFVTKPflgisLGMDE---YKEELAEKVR 128
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 5-58 3.18e-04

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 37.93  E-value: 3.18e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 446422457     5 IVDDDEVFRSMLSQIIEdgDLGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMP 58
Cdd:smart00448   5 VVDDDPLLRELLKALLE--KEGYEVDEATDGE--EAlELLKEEKPDLILLDIMMP 55
 
Name Accession Description Interval E-value
YcbB pfam08664
YcbB domain; YcbB is a DNA-binding domain.
 159-299 7.59e-66

YcbB domain; YcbB is a DNA-binding domain.


Pssm-ID: 462553  Cd Length: 136  Bit Score: 202.83  E-value: 7.59e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457  159 SGRFLLSELGIAGENGSKDLLSMLEYLYGQEKAQTFEFGFPALKDIFHQIIVKKLgelASDADIEKERKASEQRVRRAIY 238
Cdd:pfam08664   1 KGQFILSELGIIGESGSKDLLDIVEWLIEQEKEGLSEKSFPSLKDIYEELASKKE---SSDEDIEKEIKAIEQRIRRAIK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446422457  239 QSLNHLASLGLTDFSNPKFESYAPKFFDFTVVRKRMTEMTKDEvaTSGHIRINTKKFIQVL 299
Cdd:pfam08664  78 QALTHLASLGLTDYSNPKFEEYASKLFDFTEVRKEMKELRGKS--SSSKGRINVKKFIEGL 136
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 3-105 1.36e-38

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 132.01  E-value: 1.36e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   3 YYIVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAfIEAEQLNYKKVDILFIDLLMPMRDGIETVRHI-ASSFTGKIIMIS 81
Cdd:cd17565    1 FYIVDDDKNIIKILSDIIEDDDLGEVVGEADNGA-QAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLkDTGSNGKFIMIS 79

                         90       100
                 ....*....|....*....|....
gi 446422457  82 QVESKQLIGEAYTLGVEYYITKPL 105
Cdd:cd17565   80 QVSDKEMIGKAYQAGIEFFINKPI 103
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 4-104 3.19e-22

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 89.06  E-value: 3.19e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   4 YIVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHI-ASSFTGKIIMIS 81
Cdd:COG4753    3 LIVDDEPLIREGLKRILEWEAGFEVVGEAENGE--EAlELLEEHKPDLVITDINMPGMDGLELLEAIrELDPDTKIIILS 80

                         90       100
                 ....*....|....*....|...
gi 446422457  82 QVESKQLIGEAYTLGVEYYITKP 104
Cdd:COG4753   81 GYSDFEYAQEAIKLGADDYLLKP 103
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 5-126 1.69e-18

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 80.01  E-value: 1.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTG-KIIMISQ 82
Cdd:COG4565    8 IVEDDPMVAELLRRYLERLPGFEVVGVASSGE--EAlALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDvDVIVITA 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446422457  83 VESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIERIRLERS 126
Cdd:COG4565   86 ARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLRE 129
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 5-115 1.57e-17

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 76.81  E-value: 1.57e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457    5 IVDDDEVFRSMLSQIIEDgdLGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHI-ASSFTGKIIMISQ 82
Cdd:pfam00072   3 IVDDDPLIRELLRQLLEK--EGYVVAEADDGK--EAlELLKEERPDLILLDINMPGMDGLELLKRIrRRDPTTPVIILTA 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 446422457   83 VESKQLIGEAYTLGVEYYITKPLNKIEVVSVVR 115
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 5-104 2.95e-17

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 75.73  E-value: 2.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDgdLGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTG-KIIMISQ 82
Cdd:cd00156    2 IVDDDPAIRELLKSLLER--EGYEVDTAADGE--EAlELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDiPVIVLTA 77

                         90       100
                 ....*....|....*....|..
gi 446422457  83 VESKQLIGEAYTLGVEYYITKP 104
Cdd:cd00156   78 KADEEDAVRALELGADDYLVKP 99
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 5-117 4.82e-17

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 75.63  E-value: 4.82e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTG-KIIMISQ 82
Cdd:cd17535    3 IVDDHPLVREGLRRLLESEPDIEVVGEAADGE--EAlALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDlKVIVLTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446422457  83 VESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKV 117
Cdd:cd17535   81 HDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAV 115
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 5-117 8.01e-17

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 75.01  E-value: 8.01e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLgEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHI-ASSFTGKIIMISQ 82
Cdd:cd17542    5 IVDDAAFMRMMLKDILTKAGY-EVVGEAANGE--EAvEKYKELKPDLVTMDITMPEMDGIEALKEIkKIDPNAKVIMCSA 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446422457  83 VESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKV 117
Cdd:cd17542   82 MGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEKV 116
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 5-122 8.71e-17

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 75.07  E-value: 8.71e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLG-EVIGESEDGafIEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTG-KIIMIS 81
Cdd:cd17536    3 IVDDEPLIREGLKKLIDWEELGfEVVGEAENG--EEAlELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDiKIIILS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446422457  82 QVESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIERIR 122
Cdd:cd17536   81 GYDDFEYAQKAIRLGVVDYLLKPVDEEELEEALEKAKEELD 121
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 5-179 5.99e-16

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 77.70  E-value: 5.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLgEVIgESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTG-KIIMISQ 82
Cdd:COG2204    7 VVDDDPDIRRLLKELLERAGY-EVE-TAASGE--EAlALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDlPVILLTG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457  83 VESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIERIRLERsiydiQKSLNNVFQWEKPQMRnETVQEGKKISDSGRF 162
Cdd:COG2204   83 YGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLRR-----ENAEDSGLIGRSPAMQ-EVRRLIEKVAPSDAT 156

                        170
                 ....*....|....*...
gi 446422457 163 LLselgIAGENGS-KDLL 179
Cdd:COG2204  157 VL----ITGESGTgKELV 170
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 5-122 1.44e-15

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 71.81  E-value: 1.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDgdLG-EVIgESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTG---KIIM 79
Cdd:COG0784   10 VVDDNPDNRELLRRLLER--LGyEVT-TAEDGA--EAlELLRAGPPDLILLDINMPGMDGLELLRRIRALPRLpdiPIIA 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446422457  80 ISQVESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIERIR 122
Cdd:COG0784   85 LTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARAS 127
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 5-134 3.86e-15

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 73.28  E-value: 3.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDgdLGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGK---IIMI 80
Cdd:COG3437   11 IVDDDPENLELLRQLLRT--LGYDVVTAESGE--EAlELLLEAPPDLILLDVRMPGMDGFELLRLLRADPSTRdipVIFL 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446422457  81 SQVESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIERIRLERSIYDIQKSL 134
Cdd:COG3437   87 TALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRRLQRELDDLVLYL 140
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 5-114 1.54e-14

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 70.32  E-value: 1.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLgEVIgESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGK---IIMI 80
Cdd:COG3706    6 VVDDDPTNRKLLRRLLEAAGY-EVV-EAADGE--EAlELLQEHRPDLILLDLEMPDMDGLELCRRLRADPRTAdipIIFL 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446422457  81 SQVESKQLIGEAYTLGVEYYITKPLNKIEVVSVV 114
Cdd:COG3706   82 TALDDEEDRARALEAGADDYLTKPFDPEELLARV 115
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 5-125 1.33e-13

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 68.44  E-value: 1.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLgEVIgESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHI-ASSFTGKIIMISQ 82
Cdd:COG0745    6 VVEDDPDIRELLADALEREGY-EVD-TAADGE--EAlELLEEERPDLILLDLMLPGMDGLEVCRRLrARPSDIPIIMLTA 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446422457  83 VESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIERIRLER 125
Cdd:COG0745   82 RDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLRRRAAEV 124
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 5-126 2.02e-13

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 67.67  E-value: 2.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDgdLG-EVIGESEDGAFIEAEQLNYKkVDILFIDLLMPMRDGIETVRHIASSFTGKIIMISQV 83
Cdd:COG3707    8 VVDDEPLRRADLREGLRE--AGyEVVAEAADGEDAVELVRELK-PDLVIVDIDMPDRDGLEAARQISEERPAPVILLTAY 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446422457  84 ESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIERIRLERS 126
Cdd:COG3707   85 SDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRA 127
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 5-122 3.14e-13

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 65.49  E-value: 3.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIE-DGDLgEVIGESEDGafIEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGKIIMIS- 81
Cdd:cd17541    5 IVDDSAVMRKLLSRILEsDPDI-EVVGTARDG--EEAlEKIKELKPDVITLDIEMPVMDGLEALRRIMAERPTPVVMVSs 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 446422457  82 --QVESKQLIgEAYTLGVEYYITKP--LNKIEVVSVVRKVIERIR 122
Cdd:cd17541   82 ltEEGAEITL-EALELGAVDFIAKPsgGISLDLEEIAEELIEKIK 125
Spo0F COG5803
Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, ...
 5-119 1.02e-12

Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444505 [Multi-domain]  Cd Length: 119  Bit Score: 63.66  E-value: 1.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDgdLGEVIGESEDGafIEA-EQLNYKKVDILFIDLLMPMRDGIETVRHI-ASSFTGKIIMISQ 82
Cdd:COG5803    7 IVDDQAGIRMLLKEVLKK--EGYEVFQAANG--KEAlEKVKELKPDLVLLDMKMPGMDGIEILKEIkEIDPDIPVIMMTA 82

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446422457  83 VESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIE 119
Cdd:COG5803   83 YGELDMVEEAKELGAKGYFTKPFDIDELREAVNKLLK 119
Spo0A COG5801
Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell ...
 5-122 1.67e-12

Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444503 [Multi-domain]  Cd Length: 264  Bit Score: 66.36  E-value: 1.67e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIE-DGDLgEVIGESEDGafIEA-EQLNYKKVDILFIDLLMPMRDGI---ETVRHIASSFTGKIIM 79
Cdd:COG5801    9 IADDNREFCELLEEYLSsQPDM-EVVGVAYNG--LEAlELIEEKKPDVVILDIIMPHLDGLgvlEKLREMNLEKRPKVIM 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446422457  80 ISQVESKQLIGEAYTLGVEYYITKPLNkIEVvsvvrkVIERIR 122
Cdd:COG5801   86 LTAFGQEDITQRAVELGADYYILKPFD-LDV------LAERIR 121
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 5-126 1.29e-10

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 60.22  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDGafIEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIAS-SFTGKIIMISQ 82
Cdd:COG3279    6 IVDDEPLARERLERLLEKYPDLEVVGEASNG--EEAlELLEEHKPDLVFLDIQMPGLDGFELARQLRElDPPPPIIFTTA 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446422457  83 VESKQLigEAYTLGVEYYITKPLNKIEVVSVVRKVIERIRLERS 126
Cdd:COG3279   84 YDEYAL--EAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAA 125
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
5-122 1.93e-10

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 60.93  E-value: 1.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIE-DGDLgEVIGESEDGafIEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGKIIMISQ 82
Cdd:PRK00742   8 VVDDSAFMRRLISEILNsDPDI-EVVGTAPDG--LEArEKIKKLNPDVITLDVEMPVMDGLDALEKIMRLRPTPVVMVSS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 446422457  83 V--ESKQLIGEAYTLGVEYYITKP-----LNKIEvvsVVRKVIERIR 122
Cdd:PRK00742  85 LteRGAEITLRALELGAVDFVTKPflgisLGMDE---YKEELAEKVR 128
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 5-69 4.18e-10

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 56.82  E-value: 4.18e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHI 69
Cdd:COG2197    6 IVDDHPLVREGLRALLEAEPDIEVVGEAADGE--EAlELLEELRPDVVLLDIRMPGMDGLEALRRL 69
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 5-106 5.06e-10

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 56.30  E-value: 5.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAFIEAEQLNykKVDILFIDLLMPMRDGIETVRHIASS-FTGKIIMISQV 83
Cdd:cd17530    5 VLDDDPFQCMMAATILEDLGPGNVDEADDGREALVILLCN--APDIIICDLKMPDMDGIEFLRHLAEShSNAAVILMSGL 82

                         90       100
                 ....*....|....*....|....*...
gi 446422457  84 -----ESKQLIGEAYTLGVEYYITKPLN 106
Cdd:cd17530   83 dggilESAETLAGANGLNLLGTLSKPFS 110
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
5-120 9.04e-10

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 57.89  E-value: 9.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIgeSEDGAfiEAEQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGKIIMISQVE 84
Cdd:PRK10955   6 LVDDDRELTSLLKELLEMEGFNVIV--AHDGE--QALDLLDDSIDLLLLDVMMPKKNGIDTLKELRQTHQTPVIMLTARG 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446422457  85 SK--QLIGeaYTLGVEYYITKPLNKIEVVSVVRKVIER 120
Cdd:PRK10955  82 SEldRVLG--LELGADDYLPKPFNDRELVARIRAILRR 117
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 5-120 9.93e-10

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 55.50  E-value: 9.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLgEVIGESEDGafIEAEQLNYK-KVDILFIDLLMPMRDGIETVRHIASSFTGKIIMISQV 83
Cdd:cd19932    5 IAEDEALIRMDLREMLEEAGY-EVVGEASDG--EEAVELAKKhKPDLVIMDVKMPRLDGIEAAKIITSENIAPIVLLTAY 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446422457  84 ESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIER 120
Cdd:cd19932   82 SQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAIAR 118
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 5-115 1.28e-09

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 55.14  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDgafIEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGK---IIMI 80
Cdd:cd17551    5 IVDDNPTNLLLLEALLRSAGYLEVVSFTDP---REAlAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPGLEdvpIVMI 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446422457  81 SQVESKQLIGEAYTLGVEYYITKPLNKIEVVSVVR 115
Cdd:cd17551   82 TADTDREVRLRALEAGATDFLTKPFDPVELLARVR 116
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 5-118 1.59e-09

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 54.61  E-value: 1.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLgEVIgESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVR----HIASSFTgKIIM 79
Cdd:cd17562    5 AVDDSASIRQMVSFTLRGAGY-EVV-EAADGR--DAlSKAQSKKFDLIITDQNMPNMDGIELIKelrkLPAYKFT-PILM 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 446422457  80 I---SQVESKQligEAYTLGVEYYITKPLNKIEVVSVVRKVI 118
Cdd:cd17562   80 LtteSSDEKKQ---EGKAAGATGWLVKPFDPEQLLEVVKKVL 118
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 5-114 1.97e-09

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 54.40  E-value: 1.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDgdLGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGK----IIM 79
Cdd:cd17546    3 VVDDNPVNRKVLKKLLEK--LGYEVDVAENGQ--EAlELLKEEPFDLVLMDLQMPVMDGLEATRRIRELEGGGrrtpIIA 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446422457  80 IS---QVESKQLIGEAytlGVEYYITKPLNKIEVVSVV 114
Cdd:cd17546   79 LTanaLEEDREKCLEA---GMDDYLSKPVKLDQLKEVL 113
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 5-104 2.39e-09

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 54.15  E-value: 2.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDGafIEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGK---IIMI 80
Cdd:cd17561    6 IADDNREFVQLLEEYLNSQPDMEVVGVAHNG--QEAlELIEEKEPDVLLLDIIMPHLDGIGVLEKLRRMRLEKrpkIIML 83

                         90       100
                 ....*....|....*....|....
gi 446422457  81 SQVESKQLIGEAYTLGVEYYITKP 104
Cdd:cd17561   84 TAFGQEDITQRAVELGASYYILKP 107
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 5-117 3.27e-09

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 53.69  E-value: 3.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDgDLGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIA-SSFTGKIIMIS- 81
Cdd:cd17593    5 ICDDSSMARKQLARALPA-DWDVEITFAENGE--EAlEILREGRIDVLFLDLTMPVMDGYEVLEALPvEQLETKVIVVSg 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446422457  82 --QVESKQLIGEaytLGVEYYITKPLNKIEVVSVVRKV 117
Cdd:cd17593   82 dvQPEAKERVLE---LGALAFLKKPFDPEKLAQLLEEL 116
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 5-103 4.85e-08

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 52.72  E-value: 4.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDG--AFIEAEQLNykkVDILFIDLLMPMRDGIETVRHI-ASSFTGKIIMIS 81
Cdd:PRK10651  11 LIDDHPMLRTGVKQLISMAPDITVVGEASNGeqGIELAESLD---PDLILLDLNMPGMNGLETLDKLrEKSLSGRIVVFS 87

                         90       100
                 ....*....|....*....|..
gi 446422457  82 QVESKQLIGEAYTLGVEYYITK 103
Cdd:PRK10651  88 VSNHEEDVVTALKRGADGYLLK 109
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 5-104 7.70e-08

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 49.94  E-value: 7.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSF-TGKIIMISQ 82
Cdd:cd19925    5 IVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGE--EAlKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGhDVDVIVVTA 82

                         90       100
                 ....*....|....*....|..
gi 446422457  83 VESKQLIGEAYTLGVEYYITKP 104
Cdd:cd19925   83 ANDVETVREALRLGVVDYLIKP 104
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
5-180 1.52e-07

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 52.54  E-value: 1.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIedGDLGEVIGESEDGAfiEAEQL-NYKKVDILFIDLLMPMRDGIETVRHIASSFTGK--IIMIS 81
Cdd:PRK11361   9 IVDDEDNVRRMLSTAF--ALQGFETHCANNGR--TALHLfADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTpvILMTA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457  82 QVESKQLIgEAYTLGVEYYITKPLNKIEVVSVVRKVIERIRLERSIYDIQKSLNNVFQWEK-----PQMRnETVQEGKKI 156
Cdd:PRK11361  85 YAEVETAV-EALRCGAFDYVIKPFDLDELNLIVQRALQLQSMKKEIRHLHQALSTSWQWGHiltnsPAMM-DICKDTAKI 162

                        170       180
                 ....*....|....*....|....*
gi 446422457 157 SDSGRFLLselgIAGENGS-KDLLS 180
Cdd:PRK11361 163 ALSQASVL----ISGESGTgKELIA 183
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 5-116 2.70e-07

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 48.21  E-value: 2.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGdlGEVIGESEDGAfIEAEQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGKIIMIS--- 81
Cdd:cd17594    4 VVDDDAAMRHLLILYLRER--GFDVTAAADGA-EEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRARSDVPIIIISgdr 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446422457  82 QVESKQLIGeaYTLGVEYYITKPLNKIEVVSVVRK 116
Cdd:cd17594   81 RDEIDRVVG--LELGADDYLAKPFGLRELLARVRA 113
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 5-110 3.22e-07

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 48.35  E-value: 3.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGdlGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTG-KIIMISQ 82
Cdd:cd17555    5 VIDDDEVVRESIAAYLEDS--GFQVLQAADGR--QGlELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDtPVIVVSG 80

                         90       100
                 ....*....|....*....|....*...
gi 446422457  83 VESKQLIGEAYTLGVEYYITKPLNKIEV 110
Cdd:cd17555   81 AGVMSDAVEALRLGAWDYLTKPIEDLAV 108
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 5-111 3.54e-07

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 48.10  E-value: 3.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIedGDLG-EVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGK---IIM 79
Cdd:cd19923    5 VVDDFSTMRRIIKNLL--KELGfNNVEEAEDGV--DAlEKLKAGGFDFVITDWNMPNMDGLELLKTIRADGALShlpVLM 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446422457  80 ISQVESKQLIGEAYTLGVEYYITKPLN------KIEVV 111
Cdd:cd19923   81 VTAEAKKENVIAAAQAGVNNYIVKPFTaatlkeKLEKI 118
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 5-115 2.16e-06

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 45.84  E-value: 2.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGdlGEVIGESEDGAFIEAEqLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGKIIMIS--Q 82
Cdd:cd17619    5 IVEDEPVTRATLKSYFEQE--GYDVSEAGDGEEMRQI-LARQDIDLVLLDINLPGKDGLSLTRELREQSEVGIILVTgrD 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 446422457  83 VESKQLIGeaYTLGVEYYITKPLNKIEVVSVVR 115
Cdd:cd17619   82 DEVDRIVG--LEIGADDYVTKPFNPRELLVRAK 112
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
5-121 2.69e-06

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 47.41  E-value: 2.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAfieAEQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGK---IIMIS 81
Cdd:PRK10161   7 VVEDEAPIREMVCFVLEQNGFQPVEAEDYDSA---VNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTRdipVVMLT 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446422457  82 QVESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIERI 121
Cdd:PRK10161  84 ARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRI 123
PRK09483 PRK09483
response regulator; Provisional
 4-117 3.15e-06

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 47.41  E-value: 3.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   4 YIVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAfiEAEQL-NYKKVDILFIDLLMPMRDGIETVRHIASSFTG-KIIMIS 81
Cdd:PRK09483   5 LLVDDHELVRAGIRRILEDIKGIKVVGEACCGE--DAVKWcRTNAVDVVLMDMNMPGIGGLEATRKILRYTPDvKIIMLT 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446422457  82 QVESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKV 117
Cdd:PRK09483  83 VHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSV 118
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 5-115 4.36e-06

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 45.15  E-value: 4.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAFIEAEQLnykKVDILFIDLLMPMRDGIETVRHIASSFTGKIIMISQVE 84
Cdd:cd17626    5 VVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREV---RPDLVLLDLMLPGIDGIEVCRQIRAESGVPIVMLTAKS 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 446422457  85 SKQLIGEAYTLGVEYYITKPLNKIEVVSVVR 115
Cdd:cd17626   82 DTVDVVLGLESGADDYVAKPFKPKELVARIR 112
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 5-103 5.34e-06

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 44.65  E-value: 5.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDGA-FIE-AEQLNykkVDILFIDLLMPMRDGIETVRHI-ASSFTGKIIMIS 81
Cdd:cd19931    3 LIDDHPLLRKGIKQLIELDPDFTVVGEASSGEeGIElAERLD---PDLILLDLNMKGMSGLDTLKALrEEGVSARIVILT 79

                         90       100
                 ....*....|....*....|..
gi 446422457  82 QVESKQLIGEAYTLGVEYYITK 103
Cdd:cd19931   80 VSDAEDDVVTALRAGADGYLLK 101
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 49-120 7.39e-06

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 44.34  E-value: 7.39e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446422457  49 DILFIDLLMPMRDGIETVRHIASSFTGKIIMISQVESK--QLIGeaYTLGVEYYITKPLNKIEVVSVVRKVIER 120
Cdd:cd17614   44 DLILLDLMLPEKDGLEVCREVRKTSNVPIIMLTAKDSEvdKVLG--LELGADDYVTKPFSNRELLARVKANLRR 115
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 5-120 8.42e-06

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 44.07  E-value: 8.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDGafIEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTG-KIIMISQ 82
Cdd:cd17532    3 IVDDEPLAREELRYLLEEHPDIEIVGEAENG--EEAlEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPpLIVFVTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446422457  83 VESKQLigEAYTLGVEYYITKPLNKIEVVSVVRKVIER 120
Cdd:cd17532   81 YDEYAV--EAFELNAVDYLLKPFSEERLAEALAKLRKR 116
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 5-120 1.15e-05

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 43.91  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGdlGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASsfTGKIIMISQV 83
Cdd:cd17627    3 VVDDDRAVRESLRRSLRFE--GYEVETAVDGA--EAlRVISGNRPDAVVLDVMMPRLDGLEVCRRLRA--AGNDLPILVL 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446422457  84 ESKQLIGEAYT---LGVEYYITKPLNKIEVVSVVRKVIER 120
Cdd:cd17627   77 TARDSVSDRVAgldAGADDYLVKPFALEELLARVRALLRR 116
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 5-120 1.36e-05

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 43.45  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIE-DGDLGEVIGESEDGAfieaEQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGKIIMISQV 83
Cdd:cd17623    3 LIDDDRELTELLTEYLEmEGFNVRAAHDGEQGL----AALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQVPVLMLTAR 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446422457  84 --ESKQLIGeaYTLGVEYYITKPLNKIEVVSVVRKVIER 120
Cdd:cd17623   79 gdDIDRILG--LELGADDYLPKPFNPRELVARIRAILRR 115
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 5-119 1.76e-05

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 43.25  E-value: 1.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGdlGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTG-KIIMISQ 82
Cdd:cd17550    3 IVDDEEDIRESLSGILEDE--GYEVDTAADGE--EAlKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDlPVIMISG 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446422457  83 VESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIE 119
Cdd:cd17550   79 HGTIETAVKATKLGAYDFIEKPLSLDRLLLTIERALE 115
PRK10693 PRK10693
two-component system response regulator RssB;
31-105 2.88e-05

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 44.98  E-value: 2.88e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446422457  31 ESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIAS-SFTGKIIMISQVESKQLIGEAYTLGVEYYITKPL 105
Cdd:PRK10693   2 LAANGV--DAlELLGGFTPDLIICDLAMPRMNGIEFVEHLRNrGDQTPVLVISATENMADIAKALRLGVQDVLLKPV 76
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 49-118 3.06e-05

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 42.37  E-value: 3.06e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446422457  49 DILFIDLLMPMRDGIETVRHIASSFTGKIIMIS-QVES-KQLIGeaYTLGVEYYITKPLNKIEVVSVVRKVI 118
Cdd:cd19938   45 DLILLDLMLPGTDGLTLCREIRRFSDVPIIMVTaRVEEiDRLLG--LELGADDYICKPYSPREVVARVKAIL 114
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
5-69 3.57e-05

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 44.87  E-value: 3.57e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446422457   5 IVDDDEVFRSMLSQIIE-DGDLgEVIGESEDGAF-IE--AEQLNykkvDILFIDLLMPMRDGIETVRHI 69
Cdd:PRK12555   5 IVNDSPLAVEALRRALArDPDH-EVVWVATDGAQaVErcAAQPP----DVILMDLEMPRMDGVEATRRI 68
PRK10766 PRK10766
two-component system response regulator TorR;
5-141 3.99e-05

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 43.87  E-value: 3.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGdlGEVIGESEDGAFIEaEQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGKIIMIS-QV 83
Cdd:PRK10766   7 VVEDEPVTRARLQGYFEQE--GYTVSEAASGAGMR-EIMQNQHVDLILLDINLPGEDGLMLTRELRSRSTVGIILVTgRT 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446422457  84 ES-KQLIGeaYTLGVEYYITKPLNKIEVVSVVRKVIERIRLERSIYDIQKSLNNVFQWE 141
Cdd:PRK10766  84 DSiDRIVG--LEMGADDYVTKPLELRELLVRVKNLLWRISLARQAQPHAQEEDNCYRFA 140
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 5-104 4.13e-05

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 42.37  E-value: 4.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLgEVIGESEDGAFIEAEQLNykKVDILFIDLLMPMRDGIETVRHIASSFTGKIIMISQVE 84
Cdd:cd17622    5 LVEDDPKLARLIADFLESHGF-NVVVEHRGDRALEVIARE--KPDAVLLDIMLPGIDGLTLCRDLRPKYQGPILLLTALD 81

                         90       100
                 ....*....|....*....|..
gi 446422457  85 S--KQLIGeaYTLGVEYYITKP 104
Cdd:cd17622   82 SdiDHILG--LELGADDYVVKP 101
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 5-104 9.55e-05

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 40.85  E-value: 9.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDgdLG-EVIgESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHI-ASSFTGKIIMIS 81
Cdd:cd17574    2 VVEDDEEIAELLSDYLEK--EGyEVD-TAADGE--EAlELAREEQPDLIILDVMLPGMDGFEVCRRLrEKGSDIPIIMLT 76

                         90       100
                 ....*....|....*....|...
gi 446422457  82 QVESKQLIGEAYTLGVEYYITKP 104
Cdd:cd17574   77 AKDEEEDKVLGLELGADDYITKP 99
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 4-118 1.95e-04

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 40.33  E-value: 1.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   4 YIVDDDEVFRSMLSQIIEDGdlGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGK---IIM 79
Cdd:cd19937    1 LVVDDEEDIVELLKYNLEKE--GYEVVTAYDGE--EAlKRAKDEKPDLIILDLMLPGIDGLEVCRILRSDPKTSsipIIM 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446422457  80 IS--QVESKQLIGeaYTLGVEYYITKPLNKIEVVSVVRKVI 118
Cdd:cd19937   77 LTakGEEFDKVLG--LELGADDYITKPFSPRELLARVKAVL 115
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 5-58 3.18e-04

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 37.93  E-value: 3.18e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 446422457     5 IVDDDEVFRSMLSQIIEdgDLGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMP 58
Cdd:smart00448   5 VVDDDPLLRELLKALLE--KEGYEVDEATDGE--EAlELLKEEKPDLILLDIMMP 55
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 49-133 3.23e-04

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 41.21  E-value: 3.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457  49 DILFIDLLMPMRDGIETVRHIASSFTGKIIMISQV--ESKQLIGeaYTLGVEYYITKPLNKIEVVSVVRKVIERIRLERS 126
Cdd:PRK10710  56 DLILLDLMLPGTDGLTLCREIRRFSDIPIVMVTAKieEIDRLLG--LEIGADDYICKPYSPREVVARVKTILRRCKPQRE 133


                 ....*..
gi 446422457 127 IYDIQKS 133
Cdd:PRK10710 134 LQQQDAE 140
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 5-135 3.80e-04

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 41.34  E-value: 3.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLgEVIGESEDGAFieAEQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGKIIMISQV- 83
Cdd:PRK13856   6 VIDDDVAMRHLIVEYLTIHAF-KVTAVADSQQF--NRVLASETVDVVVVDLNLGREDGLEIVRSLATKSDVPIIIISGDr 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457  84 --ESKQLIgeAYTLGVEYYITKP------LNKIEVVSVVRKVIERIRLERSIYDIQKSLN 135
Cdd:PRK13856  83 leEADKVV--ALELGATDFIAKPfgtrefLARIRVALRVRPNVVRTKDRRSFCFADWTLN 140
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 6-118 4.38e-04

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 39.15  E-value: 4.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   6 VDDDEVFRSMLSQIIEDgdLG-EVIGESEDGAFIEAEQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGKIIMISQVE 84
Cdd:cd17584    4 VDDDPTCLAILKRMLLR--CGyQVTTCTDAEEALSMLRENKDEFDLVITDVHMPDMDGFEFLELIRLEMDLPVIMMSADG 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446422457  85 SKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVI 118
Cdd:cd17584   82 STSTVMKGLAHGACDYLLKPVSIEDLKNIWQHVV 115
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 49-120 4.40e-04

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 39.28  E-value: 4.40e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446422457  49 DILFIDLLMPMRDGIETVRHIASSFTGKIIMIS--QVESKQLIGeaYTLGVEYYITKPLNKIEVVSVVRKVIER 120
Cdd:cd19939   45 SLVVLDIMLPGMDGLTVCREVREHSHVPILMLTarTEEMDRVLG--LEMGADDYLCKPFSPRELLARVRALLRR 116
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 5-117 4.88e-04

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 39.15  E-value: 4.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAfieAEQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGK---IIMIS 81
Cdd:cd17618    5 IVEDEPAIREMIAFNLERAGFDVVEAEDAESA---VNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRDEMTRdipIIMLT 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446422457  82 QVESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKV 117
Cdd:cd17618   82 ARGEEEDKVRGLEAGADDYITKPFSPRELVARIKAV 117
ompR PRK09468
osmolarity response regulator; Provisional
 5-120 6.56e-04

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 40.34  E-value: 6.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGdlGEVIGESEDgafieAEQLN----YKKVDILFIDLLMPMRDGIETVRHI-ASSFTGKIIM 79
Cdd:PRK09468  10 VVDDDMRLRALLERYLTEQ--GFQVRSAAN-----AEQMDrlltRESFHLMVLDLMLPGEDGLSICRRLrSQNNPTPIIM 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446422457  80 ISQV--ESKQLIGeaYTLGVEYYITKPLNKIEVVSVVRKVIER 120
Cdd:PRK09468  83 LTAKgeEVDRIVG--LEIGADDYLPKPFNPRELLARIRAVLRR 123
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 5-120 7.74e-04

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 38.42  E-value: 7.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIedGDLGEVIGESEDG--AFIEAEQLNYkkvDILFIDLLMPMRDGIETVRHIASS-FTGKIIMIS 81
Cdd:cd19934    3 LVEDDALLAAQLKEQL--SDAGYVVDVAEDGeeALFQGEEEPY---DLVVLDLGLPGMDGLSVLRRWRSEgRATPVLILT 77

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446422457  82 QVESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIER 120
Cdd:cd19934   78 ARDSWQDKVEGLDAGADDYLTKPFHIEELLARLRALIRR 116
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 5-104 8.47e-04

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 38.13  E-value: 8.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAFIEaeqLNYKKVDILFIDLLMPMRDG---IETVRHIASSFTGKIIMIS 81
Cdd:cd19927    3 LVDDDPGIRLAVKDYLEDQGFTVIAASNGLEALDL---LNQYIPDLIISDIIMPGVDGyslLGKLRKNADFDTIPVIFLT 79

                         90       100
                 ....*....|....*....|....*
gi 446422457  82 Q--VESKQLIGeaYTLGVEYYITKP 104
Cdd:cd19927   80 AkgMTSDRIKG--YNAGCDGYLSKP 102
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 5-119 1.09e-03

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 38.55  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDG----AFI--EAEQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGK-- 76
Cdd:cd17557    4 LVEDNPGDAELIQEAFKEAGVPNELHVVRDGeealDFLrgEGEYADAPRPDLILLDLNMPRMDGFEVLREIKADPDLRri 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446422457  77 -IIMISQVESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIE 119
Cdd:cd17557   84 pVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAIRSLGE 127
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 5-104 1.13e-03

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 37.56  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIedGDLGEVIGESEDGAFIEAEqLNYKKVDILFIDLLMPMRDGIETVRHIASSFTGKIIMISQVE 84
Cdd:cd17621    3 VVEDEESFSDPLAYLL--RKEGFEVTVATDGPAALAE-FDRAGADIVLLDLMLPGLSGTEVCRQLRARSNVPVIMVTAKD 79

                         90       100
                 ....*....|....*....|..
gi 446422457  85 SK--QLIGeaYTLGVEYYITKP 104
Cdd:cd17621   80 SEidKVVG--LELGADDYVTKP 99
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 4-118 1.48e-03

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 37.64  E-value: 1.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   4 YIVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAFieaEQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTG--KIIMI- 80
Cdd:cd19919    4 WIVDDDSSIRWVLERALAGAGLTVTSFENAQEAL---AALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDlpVIIMTa 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446422457  81 -SQVESKQligEAYTLGVEYYITKPLNKIEVVSVVRKVI 118
Cdd:cd19919   81 hSDLDSAV---SAYQGGAFEYLPKPFDIDEAVALVERAI 116
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
5-81 1.50e-03

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 39.11  E-value: 1.50e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLgEVIGESEDGAFiEAEQLNYKKVDILFIDLLMPMRDGIETVRHI-ASSFTGKIIMIS 81
Cdd:PRK09958   5 IIDDHPLAIAAIRNLLIKNDI-EILAELTEGGS-AVQRVETLKPDIVIIDVDIPGVNGIQVLETLrKRQYSGIIIIVS 80
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 5-117 1.58e-03

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 37.59  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGdlGEVIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIASSFTG-KIIMISQ 82
Cdd:cd17554    5 VVDDEENIRELYKEELEDE--GYEVVTAGNGE--EAlEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDlPVIICTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446422457  83 V-ESKQligEAYTLGVEYYITKPLNKIEVVSVVRKV 117
Cdd:cd17554   81 YsEYKS---DFSSWAADAYVVKSSDLTELKETIKRL 113
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 5-125 2.36e-03

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 37.18  E-value: 2.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGevIGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIETVRHIA-SSFTGKIIMISQ 82
Cdd:cd17572    3 LVEDSPSLAALYQEYLSDEGYK--VTHVETGK--EAlAFLSDQPPDVVLLDLKLPDMSGMEILKWIQeRSLPTSVIVITA 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446422457  83 VESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIERIRLER 125
Cdd:cd17572   79 HGSVDIAVEAMRLGAYDFLEKPFDADRLRVTVRNALKHRKLTK 121
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 5-104 2.60e-03

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 36.76  E-value: 2.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAFIEAEQlnyKKVDILFIDLLMPMRDGIETVRHIASSFTGKIIMISQVE 84
Cdd:cd17620    3 VIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLLEAAT---RKPDLIILDLGLPDMDGLEVIRRLREWSAVPVIVLSARD 79

                         90       100
                 ....*....|....*....|
gi 446422457  85 SKQLIGEAYTLGVEYYITKP 104
Cdd:cd17620   80 EESDKIAALDAGADDYLTKP 99
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 5-120 2.95e-03

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 38.25  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAFIEAEQlnyKKVDILFIDLLMPMRDGIETVRHIASSFTGKIIMISQVE 84
Cdd:PRK10529   6 IVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAAT---RKPDLIILDLGLPDGDGIEFIRDLRQWSAIPVIVLSARS 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446422457  85 SKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIER 120
Cdd:PRK10529  83 EESDKIAALDAGADDYLSKPFGIGELQARLRVALRR 118
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 5-119 4.19e-03

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 36.48  E-value: 4.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAfiEAEQLNYK-KVDILFIDLLMPMRDGIETVRHIASSFTG-KIIMISQ 82
Cdd:cd19930    3 IAEDQEMVRGALAALLELEDDLEVVAQASNGQ--EALRLVLKhSPDVAILDIEMPGRTGLEVAAELREELPDtKVLIVTT 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446422457  83 VESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIE 119
Cdd:cd19930   81 FGRPGYFRRALAAGVDGYVLKDRPIEELADAIRTVHA 117
PRK10610 PRK10610
chemotaxis protein CheY;
3-121 5.00e-03

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 36.49  E-value: 5.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   3 YYIVDDDEVFRSMLSQIIEDGDLGEViGESEDGAfiEA-EQLNYKKVDILFIDLLMPMRDGIE---TVRHIASSFTGKII 78
Cdd:PRK10610   8 FLVVDDFSTMRRIVRNLLKELGFNNV-EEAEDGV--DAlNKLQAGGFGFVISDWNMPNMDGLEllkTIRADGAMSALPVL 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446422457  79 MISQVESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIERI 121
Cdd:PRK10610  85 MVTAEAKKENIIAAAQAGASGYVVKPFTAATLEEKLNKIFEKL 127
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 5-114 5.18e-03

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 36.23  E-value: 5.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   5 IVDDDEVFRSMLSQIIEDgdLG-EVIGESEDG--AFIEAEQLnykKVDILFIDLLMP--MrDGIETVRHIASSFTGKIIM 79
Cdd:cd17534    5 IVEDEAIIALDLKEILES--LGyEVVGIADSGeeAIELAEEN---KPDLILMDINLKgdM-DGIEAAREIREKFDIPVIF 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446422457  80 I---SQVESKQLIGEAYTLGveyYITKPLNKIEVVSVV 114
Cdd:cd17534   79 LtaySDEETLERAKETNPYG---YLVKPFNERELKAAI 113
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 4-122 5.40e-03

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 38.31  E-value: 5.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   4 YIVDDDEVFRSMLSQIIEDGDLGEVIGESEDGAFieaEQLNYKKVDILFIDLLMPMRDGIETVRHIASS--FTGKIIMIS 81
Cdd:PRK10923   7 WVVDDDSSIRWVLERALAGAGLTCTTFENGNEVL---EALASKTPDVLLSDIRMPGMDGLALLKQIKQRhpMLPVIIMTA 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446422457  82 QVESKQLIgEAYTLGVEYYITKPLNKIEVVSVVRKVIERIR 122
Cdd:PRK10923  84 HSDLDAAV-SAYQQGAFDYLPKPFDIDEAVALVERAISHYQ 123
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 4-126 6.95e-03

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 37.00  E-value: 6.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422457   4 YIVDDDEVFRSMLSQIIEDGDLgEVIG-ESEDgAFIEAEQLNykKVDILFIDLLMPMRDGIETVRHIASSFTGK-IIMIS 81
Cdd:COG4566    3 YIVDDDEAVRDSLAFLLESAGL-RVETfASAE-AFLAALDPD--RPGCLLLDVRMPGMSGLELQEELAARGSPLpVIFLT 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446422457  82 qveskqliG--------EAYTLGVEYYITKPLNKIEVVSVVRKVIERIRLERS 126
Cdd:COG4566   79 --------GhgdvpmavRAMKAGAVDFLEKPFDDQALLDAVRRALARDRARRA 123
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 49-120 9.51e-03

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 35.41  E-value: 9.51e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446422457  49 DILFIDLLMPMRDGIETVRHI-ASSFTGKIIMISQVESKQLIGEAYTLGVEYYITKPLNKIEVVSVVRKVIER 120
Cdd:cd17615   45 DAVVLDIMLPDMDGLEVLRRLrADGPDVPVLFLTAKDSVEDRIAGLTAGGDDYVTKPFSLEEVVARLRALLRR 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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