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Conserved domains on  [gi|446422744|ref|WP_000500599|]
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MULTISPECIES: hypothetical protein [Bacillus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RapH_N super family cl40096
response regulator aspartate phosphatase H, N terminal; Rap proteins consist of a N-terminal ...
 5-66 1.52e-07

response regulator aspartate phosphatase H, N terminal; Rap proteins consist of a N-terminal 3-helix bundle and a tetratricopeptide domain. This entry represents the conserved region of the C-terminal bundle.


The actual alignment was detected with superfamily member pfam18801:

Pssm-ID: 436748  Cd Length: 62  Bit Score: 47.92  E-value: 1.52e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446422744    5 VVTREQMRHLLDDWYHSMLKQDVVKAKVLNEEIESKVIYIKEDQYAAFYHALLKFRYHVLID 66
Cdd:pfam18801   1 KIASEEVGAKINEWYSCIKKRDVEQAEILKEEVEQLLDEMEEDQDVLLYYSLVEFRHQLMLD 62
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 128-275 2.08e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


:

Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.18  E-value: 2.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422744 128 LEHAEFNYRFAYLSYQTYKPLMAIDQIRLAKDEYEKHPGYEVCIALCENIFAMACIDLKQYEQAEEKLNLALDVFQKIdn 207
Cdd:COG5010   10 LPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNN-- 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446422744 208 erfiTMVRHNLAWLYASQNLSSLAIRHLVEVIKSNSKHFKAMFVLAREYYKIGKIDTAAELIEKGLDI 275
Cdd:COG5010   88 ----PELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGT 151
 
Name Accession Description Interval E-value
RapH_N pfam18801
response regulator aspartate phosphatase H, N terminal; Rap proteins consist of a N-terminal ...
 5-66 1.52e-07

response regulator aspartate phosphatase H, N terminal; Rap proteins consist of a N-terminal 3-helix bundle and a tetratricopeptide domain. This entry represents the conserved region of the C-terminal bundle.


Pssm-ID: 436748  Cd Length: 62  Bit Score: 47.92  E-value: 1.52e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446422744    5 VVTREQMRHLLDDWYHSMLKQDVVKAKVLNEEIESKVIYIKEDQYAAFYHALLKFRYHVLID 66
Cdd:pfam18801   1 KIASEEVGAKINEWYSCIKKRDVEQAEILKEEVEQLLDEMEEDQDVLLYYSLVEFRHQLMLD 62
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 128-275 2.08e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.18  E-value: 2.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422744 128 LEHAEFNYRFAYLSYQTYKPLMAIDQIRLAKDEYEKHPGYEVCIALCENIFAMACIDLKQYEQAEEKLNLALDVFQKIdn 207
Cdd:COG5010   10 LPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNN-- 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446422744 208 erfiTMVRHNLAWLYASQNLSSLAIRHLVEVIKSNSKHFKAMFVLAREYYKIGKIDTAAELIEKGLDI 275
Cdd:COG5010   88 ----PELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGT 151
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 113-271 5.11e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.91  E-value: 5.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422744  113 HFEEAGKLikyiTSSLEHAEFNYRFAYLSYQTYKPLMAIdqirlAKDEYEKHPGYevciALCENIFAMACIDLKQYEQAE 192
Cdd:TIGR02917 419 DLETAAQL----DPELGRADLLLILSYLRSGQFDKALAA-----AKKLEKKQPDN----ASLHNLLGAIYLGKGDLAKAR 485

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446422744  193 EKLNLALdvfqKIDNERFITmvRHNLAWLYASQNLSSLAIRHLVEVIKSNSKHFKAMFVLAREYYKIGKIDTAAELIEK 271
Cdd:TIGR02917 486 EAFEKAL----SIEPDFFPA--AANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEK 558
 
Name Accession Description Interval E-value
RapH_N pfam18801
response regulator aspartate phosphatase H, N terminal; Rap proteins consist of a N-terminal ...
 5-66 1.52e-07

response regulator aspartate phosphatase H, N terminal; Rap proteins consist of a N-terminal 3-helix bundle and a tetratricopeptide domain. This entry represents the conserved region of the C-terminal bundle.


Pssm-ID: 436748  Cd Length: 62  Bit Score: 47.92  E-value: 1.52e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446422744    5 VVTREQMRHLLDDWYHSMLKQDVVKAKVLNEEIESKVIYIKEDQYAAFYHALLKFRYHVLID 66
Cdd:pfam18801   1 KIASEEVGAKINEWYSCIKKRDVEQAEILKEEVEQLLDEMEEDQDVLLYYSLVEFRHQLMLD 62
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 128-275 2.08e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.18  E-value: 2.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422744 128 LEHAEFNYRFAYLSYQTYKPLMAIDQIRLAKDEYEKHPGYEVCIALCENIFAMACIDLKQYEQAEEKLNLALDVFQKIdn 207
Cdd:COG5010   10 LPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNN-- 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446422744 208 erfiTMVRHNLAWLYASQNLSSLAIRHLVEVIKSNSKHFKAMFVLAREYYKIGKIDTAAELIEKGLDI 275
Cdd:COG5010   88 ----PELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGT 151
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 179-275 7.34e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.10  E-value: 7.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422744 179 AMACIDLKQYEQAEEKLNLALDVFQkidNERfitMVRHNLAWLYASQNLSSLAIRHLVEVIKSNSKHFKAMFVLAREYYK 258
Cdd:COG4783   45 GEILLQLGDLDEAIVLLHEALELDP---DEP---EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRA 118

                         90
                 ....*....|....*..
gi 446422744 259 IGKIDTAAELIEKGLDI 275
Cdd:COG4783  119 LGRPDEAIAALEKALEL 135
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 179-275 1.35e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.83  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422744 179 AMACIDLKQYEQAEEKLNLALDvfQKIDNerfiTMVRHNLAWLYASQNLSSLAIRHLVEVIKSNSKHFKAMFVLAREYYK 258
Cdd:COG3914  119 GNLLLALGRLEEALAALRRALA--LNPDF----AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQD 192

                         90
                 ....*....|....*..
gi 446422744 259 IGKIDTAAELIEKGLDI 275
Cdd:COG3914  193 LGRLEEAIAAYRRALEL 209
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
179-275 1.86e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.69  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422744 179 AMACIDLKQYEQAEEKLNLALDVFQKIDNerfitmVRHNLAWLYASQNLSSLAIRHLVEVIKSNSKHFKAMFVLAREYYK 258
Cdd:COG0457   15 GLAYRRLGRYEEAIEDYEKALELDPDDAE------ALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQA 88

                         90
                 ....*....|....*..
gi 446422744 259 IGKIDTAAELIEKGLDI 275
Cdd:COG0457   89 LGRYEEALEDYDKALEL 105
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 184-275 2.24e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.76  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422744 184 DLKQYEQAEEKLNLALdvfqKIDNERfiTMVRHNLAWLYASQNLSSLAIRHLVEVIKSNSKHFKAMFVLAREYYKIGKID 263
Cdd:COG4235   29 RLGRYDEALAAYEKAL----RLDPDN--ADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYA 102

                         90
                 ....*....|..
gi 446422744 264 TAAELIEKGLDI 275
Cdd:COG4235  103 EAIAAWQKLLAL 114
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
179-275 3.81e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.53  E-value: 3.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422744 179 AMACIDLKQYEQAEEKLNLALdvfqKIDNERFITMvrHNLAWLYASQNLSSLAIRHLVEVIKSNSKHFKAMFVLAREYYK 258
Cdd:COG0457   49 GLAYLRLGRYEEALADYEQAL----ELDPDDAEAL--NNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLE 122

                         90
                 ....*....|....*..
gi 446422744 259 IGKIDTAAELIEKGLDI 275
Cdd:COG0457  123 LGRYDEAIEAYERALEL 139
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
181-275 9.08e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.23  E-value: 9.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422744 181 ACIDLKQYEQAEEKLNLALdvfqKIDNERfiTMVRHNLAWLYASQNLSSLAIRhLVEVIKSNSKHFKAMFVLAREYYKIG 260
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKAL----ELDPDN--ADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELG 73

                         90
                 ....*....|....*
gi 446422744 261 KIDTAAELIEKGLDI 275
Cdd:COG3063   74 DYDEALAYLERALEL 88
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 179-275 1.19e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.63  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422744 179 AMACIDLKQYEQAEEKLNLALDVFQkiDNERfitmVRHNLAWLYASQNLSSLAIRHLVEVIKSNSKHFKAMFVLAREYYK 258
Cdd:COG4783   11 AQALLLAGDYDEAEALLEKALELDP--DNPE----AFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                         90
                 ....*....|....*..
gi 446422744 259 IGKIDTAAELIEKGLDI 275
Cdd:COG4783   85 AGDYDEALALLEKALKL 101
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
179-274 2.65e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.83  E-value: 2.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422744 179 AMACIDLKQYEQAEEKLNLALdvfqKIDNERFitMVRHNLAWLYASQNLSSLAIRHLVEVIKSNSKHFKAMFVLAREYYK 258
Cdd:COG0457   83 GLALQALGRYEEALEDYDKAL----ELDPDDA--EALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEK 156

                         90
                 ....*....|....*.
gi 446422744 259 IGKIDTAAELIEKGLD 274
Cdd:COG0457  157 LGRYEEALELLEKLEA 172
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 113-271 5.11e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.91  E-value: 5.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422744  113 HFEEAGKLikyiTSSLEHAEFNYRFAYLSYQTYKPLMAIdqirlAKDEYEKHPGYevciALCENIFAMACIDLKQYEQAE 192
Cdd:TIGR02917 419 DLETAAQL----DPELGRADLLLILSYLRSGQFDKALAA-----AKKLEKKQPDN----ASLHNLLGAIYLGKGDLAKAR 485

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446422744  193 EKLNLALdvfqKIDNERFITmvRHNLAWLYASQNLSSLAIRHLVEVIKSNSKHFKAMFVLAREYYKIGKIDTAAELIEK 271
Cdd:TIGR02917 486 EAFEKAL----SIEPDFFPA--AANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEK 558
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 187-275 5.26e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.17  E-value: 5.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446422744 187 QYEQAEEKLNLALdvfqKIDNERFitMVRHNLAWLYASQNLSSLAIRHLVEVIKSNSKHFKAMFVLAREYYKIGKIDTAA 266
Cdd:COG2956   23 QPDKAIDLLEEAL----ELDPETV--EAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAE 96


                 ....*....
gi 446422744 267 ELIEKGLDI 275
Cdd:COG2956   97 ELLEKLLEL 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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