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Conserved domains on  [gi|446425264|ref|WP_000503119|]
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MULTISPECIES: MFS transporter [Bacillus]

Protein Classification

MFS transporter( domain architecture ID 12947616)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 22-396 1.36e-69

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 224.80  E-value: 1.36e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  22 LMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLICGSIPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:cd06173    3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 102 ILATTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIKSFFL 181
Cdd:cd06173   83 LLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 182 LNSITFFLAVIVQLFIVFDLyKKEMVESKEHFLMSIKEGFSYIKRQHEIYGLMKIGLWVNFFASALFVSLPFIIIQNLHL 261
Cdd:cd06173  163 INALSFLLSALLLLFIRRPP-PAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 262 SSKQLGVVEGMLAVGMLIGAIALSVRKEVNNPFCSVYIGLFLFAGLSLCTVFpllvtipkVVSFMYYIAFMILTGISMMA 341
Cdd:cd06173  242 GAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL--------SPSLWLLLAALFLLGLAGGL 313

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446425264 342 VNIPMQVHLQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDMLPTSIVMMT 396
Cdd:cd06173  314 FNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL 368
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 22-396 1.36e-69

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 224.80  E-value: 1.36e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  22 LMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLICGSIPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:cd06173    3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 102 ILATTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIKSFFL 181
Cdd:cd06173   83 LLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 182 LNSITFFLAVIVQLFIVFDLyKKEMVESKEHFLMSIKEGFSYIKRQHEIYGLMKIGLWVNFFASALFVSLPFIIIQNLHL 261
Cdd:cd06173  163 INALSFLLSALLLLFIRRPP-PAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 262 SSKQLGVVEGMLAVGMLIGAIALSVRKEVNNPFCSVYIGLFLFAGLSLCTVFpllvtipkVVSFMYYIAFMILTGISMMA 341
Cdd:cd06173  242 GAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL--------SPSLWLLLAALFLLGLAGGL 313

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446425264 342 VNIPMQVHLQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDMLPTSIVMMT 396
Cdd:cd06173  314 FNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL 368
2A0121 TIGR00900
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
 22-388 1.42e-46

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162098 [Multi-domain]  Cd Length: 365  Bit Score: 164.03  E-value: 1.42e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264   22 LMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLICGSIPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:TIGR00900   3 LLFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAVLP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  102 ILATTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIKSFFL 181
Cdd:TIGR00900  83 FVALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAIW 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  182 LNSITFFLAVIVQLFI-VFDLYKKEMVESKEHFLMSIKEGFSYIKRQHEIYGLMKIGLWVNF-FASALFVSLPFIIIQNL 259
Cdd:TIGR00900 163 VDAVGFAISALLIVSVrIPELAASEIQALSNAVLRDTREGIKFVLKNPLLRTLLLLALLFNLvFAPAIVALFPYVQSKYL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  260 HLSSKQLGVVEGMLAVGMLIGAIALSV-RKEVNNPFcsVYIGLFLFAGLSLCTVFPLlvtiPKVVSFMYYIAFMIltGIS 338
Cdd:TIGR00900 243 GRGSTHYGWVLAAFGLGALLGALLLGLlGRYFKRMA--LMTGAIFVIGLAILVVGLT----PPNFPLFLVLWFAI--GVG 314

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 446425264  339 MMAVNIPMQVHLQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDML 388
Cdd:TIGR00900 315 YGPINVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLADHL 364
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-376 4.27e-24

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 102.36  E-value: 4.27e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  18 RNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLICGSIPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTM 97
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  98 LIMFilattFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIK 177
Cdd:COG2814   90 LLCA-----LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 178 SFFLLNSITFFLAVIVQLFIvfdlykkeMVESKEHFLMSIKEGFSYIKRQHEIYGLMKIGLWVNFFASALFVSLPFIIIQ 257
Cdd:COG2814  165 WVFLVNAVLALLALLLLLRL--------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 258 NLHLSSKQLGVVEGMLAVGMLIGAIALSVRKEVNNPFCSVYIGLFLFAGLSLCTVFpllvtipkVVSFMYYIAFMILTGI 337
Cdd:COG2814  237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL--------AGSLWLLLLALFLLGF 308

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 446425264 338 SMMAVNIPMQVHLQKTTDPSYLGRVFGLLETIATAIAPL 376
Cdd:COG2814  309 GFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
23-378 4.92e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 78.61  E-value: 4.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264   23 MMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLI-CGSIPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLtLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  102 ilattFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIKSFFL 181
Cdd:pfam07690  81 -----FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  182 LNSITFFLAVIVqLFIVFDLYKKEMVESKEHFLMSIKEGFSYIKRQHEIYGLmkIGLWVNFFASALFVSLPFIIIQNLHL 261
Cdd:pfam07690 156 ILAILSLLAAVL-LLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLL--LALLLFGFAFFGLLTYLPLYQEVLGL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  262 SSKQLGVVEGMLAVGMLIGAIALSVRKEVNNPFCSVYIGLFLFAGLSLCtvfplLVTIPKVVSFMYYIAFMILTGISMMA 341
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG-----LLLLSLTLSSLWLLLALLLLGFGFGL 307

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 446425264  342 VNIPMQVHLQKTTDPSYLGRVFGLLETIATAIAPLGM 378
Cdd:pfam07690 308 VFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
PRK10489 PRK10489
enterobactin transporter EntS;
25-391 8.88e-14

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 72.70  E-value: 8.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  25 IGKMTSLLGAGIYTFAMGLYVLKTTGSGM--GFATTLICGSiprMICGPIAGAV-ADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:PRK10489  24 IARFISIFGLGLLGVAVPVQIQMMTGSTLqvGLSVTLTGGA---MFIGLMVGGVlADRYDRKKLILLARGTCGLGFIGLA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 102 ILATTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIksffl 181
Cdd:PRK10489 101 LNAFLPEPSLLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPALGGLLIAAGGV----- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 182 lnSITFFLAVIVQLFIVFDLYK----KEMVESKEHFLMSIKEGFSYIKRQHEIYGLMKIGLWVNfFASALFVSLPFIIIQ 257
Cdd:PRK10489 176 --AWNYGLAAAGTFITLLPLLRlpalPPPPQPREHPLRSLLAGFRFLLASPVVGGIALLGGLLT-MASAVRVLYPALADE 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 258 NLHLSSKQLGVVEGMLAVGMLIGAIALSVRKEVNNPfcsvyiGLFLFaglsLCTVFPLLVTIPKVVSFMYYIAFMILTGI 337
Cdd:PRK10489 253 VWQMGAAQIGLLYAAVPLGAALGALTSGWLAHSARP------GLLML----LSTLGSFLAVGLFGLMPMWILAVLCLALF 322

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446425264 338 S-MMAVNIPMQVHL-QKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDMLPTS 391
Cdd:PRK10489 323 GyLSAISSLLQYTLlQTQTPDEMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPV 378
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 22-396 1.36e-69

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 224.80  E-value: 1.36e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  22 LMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLICGSIPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:cd06173    3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 102 ILATTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIKSFFL 181
Cdd:cd06173   83 LLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 182 LNSITFFLAVIVQLFIVFDLyKKEMVESKEHFLMSIKEGFSYIKRQHEIYGLMKIGLWVNFFASALFVSLPFIIIQNLHL 261
Cdd:cd06173  163 INALSFLLSALLLLFIRRPP-PAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 262 SSKQLGVVEGMLAVGMLIGAIALSVRKEVNNPFCSVYIGLFLFAGLSLCTVFpllvtipkVVSFMYYIAFMILTGISMMA 341
Cdd:cd06173  242 GAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL--------SPSLWLLLAALFLLGLAGGL 313

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446425264 342 VNIPMQVHLQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDMLPTSIVMMT 396
Cdd:cd06173  314 FNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL 368
2A0121 TIGR00900
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
 22-388 1.42e-46

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162098 [Multi-domain]  Cd Length: 365  Bit Score: 164.03  E-value: 1.42e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264   22 LMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLICGSIPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:TIGR00900   3 LLFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAVLP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  102 ILATTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIKSFFL 181
Cdd:TIGR00900  83 FVALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAIW 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  182 LNSITFFLAVIVQLFI-VFDLYKKEMVESKEHFLMSIKEGFSYIKRQHEIYGLMKIGLWVNF-FASALFVSLPFIIIQNL 259
Cdd:TIGR00900 163 VDAVGFAISALLIVSVrIPELAASEIQALSNAVLRDTREGIKFVLKNPLLRTLLLLALLFNLvFAPAIVALFPYVQSKYL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  260 HLSSKQLGVVEGMLAVGMLIGAIALSV-RKEVNNPFcsVYIGLFLFAGLSLCTVFPLlvtiPKVVSFMYYIAFMIltGIS 338
Cdd:TIGR00900 243 GRGSTHYGWVLAAFGLGALLGALLLGLlGRYFKRMA--LMTGAIFVIGLAILVVGLT----PPNFPLFLVLWFAI--GVG 314

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 446425264  339 MMAVNIPMQVHLQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDML 388
Cdd:TIGR00900 315 YGPINVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLADHL 364
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-376 4.27e-24

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 102.36  E-value: 4.27e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  18 RNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLICGSIPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTM 97
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  98 LIMFilattFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIK 177
Cdd:COG2814   90 LLCA-----LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 178 SFFLLNSITFFLAVIVQLFIvfdlykkeMVESKEHFLMSIKEGFSYIKRQHEIYGLMKIGLWVNFFASALFVSLPFIIIQ 257
Cdd:COG2814  165 WVFLVNAVLALLALLLLLRL--------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 258 NLHLSSKQLGVVEGMLAVGMLIGAIALSVRKEVNNPFCSVYIGLFLFAGLSLCTVFpllvtipkVVSFMYYIAFMILTGI 337
Cdd:COG2814  237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL--------AGSLWLLLLALFLLGF 308

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 446425264 338 SMMAVNIPMQVHLQKTTDPSYLGRVFGLLETIATAIAPL 376
Cdd:COG2814  309 GFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 29-386 6.45e-19

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 87.63  E-value: 6.45e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  29 TSLLGAGIYTFAMGLYVLKTTGSGMGFATTLICGSIPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMFilattFG 108
Cdd:cd17325    7 LDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA-----FA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 109 PSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIKSFFLLNSITFF 188
Cdd:cd17325   82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 189 LAVIVQLFIVFDLYKKEmvESKEHFLMSIKEGFSYIKRQHEIYGLMKIGLWVNFFASALFVSLPFIIIQNLHLSSKQLGV 268
Cdd:cd17325  162 LALVLALLLLPEPRPPP--NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 269 VEGMLAVGMLIGAIALSVRkevnnpfcSVYIG--LFLFAGLSLCTVFplLVTIPKVVSFMYYIAFMILTGISMMAVNIPM 346
Cdd:cd17325  240 LFGAQGLASALSQPPAGKL--------SDRIGrkPLILIGLLLSAVA--LLLLPLATSFWLLLLLLALLGLGLGLVFPAT 309

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 446425264 347 QVHLQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLD 386
Cdd:cd17325  310 LALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD 349
MFS_1 pfam07690
Major Facilitator Superfamily;
23-378 4.92e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 78.61  E-value: 4.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264   23 MMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLI-CGSIPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLtLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  102 ilattFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIKSFFL 181
Cdd:pfam07690  81 -----FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  182 LNSITFFLAVIVqLFIVFDLYKKEMVESKEHFLMSIKEGFSYIKRQHEIYGLmkIGLWVNFFASALFVSLPFIIIQNLHL 261
Cdd:pfam07690 156 ILAILSLLAAVL-LLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLL--LALLLFGFAFFGLLTYLPLYQEVLGL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  262 SSKQLGVVEGMLAVGMLIGAIALSVRKEVNNPFCSVYIGLFLFAGLSLCtvfplLVTIPKVVSFMYYIAFMILTGISMMA 341
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG-----LLLLSLTLSSLWLLLALLLLGFGFGL 307

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 446425264  342 VNIPMQVHLQKTTDPSYLGRVFGLLETIATAIAPLGM 378
Cdd:pfam07690 308 VFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 25-285 7.41e-14

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 73.24  E-value: 7.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264   25 IGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLICGSIPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMFILA 104
Cdd:pfam05977  17 IASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTLLTLLA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  105 TT--FGPSLLFIyvSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIKSFFLL 182
Cdd:pfam05977  97 GLglLSPWLLLG--LTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPAFTFAL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  183 NSITFFlAVIVQLFivfdLYKKEMVES---KEHFLMSIKEGFSYIKRQHEIYGLMKIGLWVNFFASALFVSLPFIIIQNL 259
Cdd:pfam05977 175 NALSYF-AVIAALW----RWKRAAPASplpRERIFGAVRAGLRFTAMSRELRSVLVRAFAFGLSASAVWALLPLVARDLL 249

                         250       260
                  ....*....|....*....|....*.
gi 446425264  260 HLSSKQLGVVEGMLAVGMLIGAIALS 285
Cdd:pfam05977 250 DGDAIFYGILLGAVGVGAILGALSLP 275
PRK10489 PRK10489
enterobactin transporter EntS;
25-391 8.88e-14

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 72.70  E-value: 8.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  25 IGKMTSLLGAGIYTFAMGLYVLKTTGSGM--GFATTLICGSiprMICGPIAGAV-ADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:PRK10489  24 IARFISIFGLGLLGVAVPVQIQMMTGSTLqvGLSVTLTGGA---MFIGLMVGGVlADRYDRKKLILLARGTCGLGFIGLA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 102 ILATTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIksffl 181
Cdd:PRK10489 101 LNAFLPEPSLLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPALGGLLIAAGGV----- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 182 lnSITFFLAVIVQLFIVFDLYK----KEMVESKEHFLMSIKEGFSYIKRQHEIYGLMKIGLWVNfFASALFVSLPFIIIQ 257
Cdd:PRK10489 176 --AWNYGLAAAGTFITLLPLLRlpalPPPPQPREHPLRSLLAGFRFLLASPVVGGIALLGGLLT-MASAVRVLYPALADE 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 258 NLHLSSKQLGVVEGMLAVGMLIGAIALSVRKEVNNPfcsvyiGLFLFaglsLCTVFPLLVTIPKVVSFMYYIAFMILTGI 337
Cdd:PRK10489 253 VWQMGAAQIGLLYAAVPLGAALGALTSGWLAHSARP------GLLML----LSTLGSFLAVGLFGLMPMWILAVLCLALF 322

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446425264 338 S-MMAVNIPMQVHL-QKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDMLPTS 391
Cdd:PRK10489 323 GyLSAISSLLQYTLlQTQTPDEMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPV 378
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 20-397 9.62e-14

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 72.26  E-value: 9.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  20 IILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFA-TTLICGSIPRMICGPIAGAVADRVNRKWLVigtdLLSSLTML 98
Cdd:cd17329    1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVgLVLALSAVAGIVASLIGGRLADRFGRKPVM----LAGLLLRA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  99 IMFILATtFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGfFSIKS 178
Cdd:cd17329   77 LGFALLG-FAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 179 FFLLNSITFFLAVIVQLFivfdLYKKEMVESKEHFLMSIKEGFSYIKRQHEIYGLMKIGLWVNFFASALFVSLPFIIIQN 258
Cdd:cd17329  155 LFLAAAVLFLLAALVLLF----LLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEI 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 259 LHLSSKQLGVVEGMLAVGMLIGAIALSVRKEVNNPFCSVYIGLFL----FAGLSLCTVFPLLVtipkVVSFMYYIAFMIL 334
Cdd:cd17329  231 LGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLfaigFAVLAFANTLAVLI----LAMIVLTLGEMLV 306

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446425264 335 TGISMMAVNIPMQVHLQKttdpSYLGrVFGLLETIATAIAPLgmiVYGLLLDMLPTSIVMMTI 397
Cdd:cd17329  307 FPAVQTLVAALAPPDKRG----SYMG-FYALAWGLGRAIGPL---VGGLLLDLLGPGLPWLIL 361
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 28-387 5.02e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 63.98  E-value: 5.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  28 MTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLICGSIPRMICGPIAGAVADRVNRKWLvigtdLLSSLTMLIMFILATTF 107
Cdd:cd06174    6 FLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPV-----LLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 108 GPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSI--KSFFLLNSI 185
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwRAVFLIAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 186 TFFLAVIVQLFIVFDLYKKEMVESKEHFLMSIKEGFSYIKRQHEIYGLMKIGLWVNFFASALFVSLPFIIIQNLHLSSKQ 265
Cdd:cd06174  161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 266 LGVVEGMLAVGMLIGAIALSVRkeVNNPFCSVYIGLFLFAGLSLCTVFPLLVTIPKVVsfmyyIAFMILTGISMMAVNIP 345
Cdd:cd06174  241 AGLLLSLFGLAGALGSLLLGLL--SDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLL-----LLLLLLLGFGLGGLLPL 313

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 446425264 346 MQVHLQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDM 387
Cdd:cd06174  314 SFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
12-344 2.48e-10

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 61.84  E-value: 2.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  12 KMKIATRNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLIcgSIPR---MICGPIAGAVADRVNRKW---- 84
Cdd:COG2211    4 KKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLIL--LVARlwdAITDPLIGALSDRTRTRWgrrr 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  85 --LVIGTdLLSSLTMLIMFiLATTFGPSLLFIYVSAA--LLSICASFYSVALTSSIPNLVD--EERIqKASALNQTAASL 158
Cdd:COG2211   82 pwILIGA-IPLALSFVLLF-TAPDLSPTGKLIYALVTylLLGLAYTLVNIPYSALGAELTPdyEERT-RLSSWRFAFAGL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 159 SNILAPIIGGVVFGFFS---IKSFFLLNSITFFLAVIVQLFIVFDLykKEMVESKEHfLMSIKEGFSYIKRQHEIYGLMK 235
Cdd:COG2211  159 GGLLASVLPPPLVAAFGgdaALGYRLTALIFAVLGLLAFLLTFFGT--KERPVPEEE-KVSLKESLKALLKNRPFLLLLL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 236 IGLWVNFFASALFVSLPFIIIQNLHLSSKQLGVVEGMLAVGMLIGAIALSVrkeVNNPFCSVYIglfLFAGLSLCTVFPL 315
Cdd:COG2211  236 AYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPR---LAKRFGKKKA---FIIGLLLAALGLL 309

                        330       340
                 ....*....|....*....|....*....
gi 446425264 316 LVTIPKVVSFMYYIAFMILTGISMMAVNI 344
Cdd:COG2211  310 LLFFLGPGNLWLLLVLAALAGIGLGAILV 338
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 20-198 4.81e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 60.67  E-value: 4.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  20 IILMMIGkmTSLLGAGIYTFAMGLYVLKTTGSGMgfatTLICGSIPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLI 99
Cdd:cd17325  208 IFVLAFA--FGALEPFLPLYAAELGGLSPAQIGL----LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 100 MfilatTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIKSF 179
Cdd:cd17325  282 L-----PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP 356

                        170
                 ....*....|....*....
gi 446425264 180 FLLNSITFFLAVIVQLFIV 198
Cdd:cd17325  357 FLAAAALLLLAAVLFLLLR 375
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 73-362 1.53e-08

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 56.86  E-value: 1.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264   73 AGAVADRVNRKWLVIGTDLLSSLTMLIMfILATTFGPsLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALN 152
Cdd:PRK08633   67 AGFLADKFSKNRVIRIVKLFEVGLTLLI-VLAYYLGW-FWLAFAVTFLLGAQSAIYSPAKYGIIPELVGKENLSRANGLL 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  153 QtaasLSNILAPIIGGVVFGFFSIKSFF-----LLNSITFFLAVIV-----QLFIVFDL------YKKEMVESKEHFLMS 216
Cdd:PRK08633  145 E----AFTIVAILAGTALFSFLFESVNGntpseILGRIAPAGLVLLavavlGLIFAYRLpkvpaaAPEVFDKKKYLFPKL 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  217 IKEGFSYIKRQHEIYgLMKIGLWVNFFASALFV-SLPFIIIQNLHLS-SKQLGVVEGMLAVGMLIGAI---ALSVRKevn 291
Cdd:PRK08633  221 LWRNLKLLRSDRVLW-LAIIGLSYFWFISQLAQaNFPAYAKEVLGLDnTFQVQYLLAASAIGIGIGSLlagRLSGRH--- 296

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446425264  292 npfcsVYIGLFLF--AGLSLCTVFpllvtIPKVVSFMYYIAFMILTGISMMAVNIPMQVHLQKTTDPSYLGRV 362
Cdd:PRK08633  297 -----IELGLVPLgaLGLALSLFL-----LPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGKV 359
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 18-197 2.73e-08

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 54.82  E-value: 2.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  18 RNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLICGSIPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTM 97
Cdd:COG0477   14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  98 LIMFILattfgPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIK 177
Cdd:COG0477   94 LLCGLA-----PSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168

                        170       180
                 ....*....|....*....|
gi 446425264 178 SFFLLNSITFFLAVIVQLFI 197
Cdd:COG0477  169 WIFLINAPLGLLALVLRLRL 188
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 67-348 1.26e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 53.32  E-value: 1.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  67 MICGPIAGAVADRVNRKWLvigtdLLSSLTMLIMFILATTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQ 146
Cdd:cd17324   48 ALGALLLGPLSDRIERRRL-----LLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRG 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 147 KASALNQTAASLSNILAPIIGGVVFGFFSIKSFFLLNSITFFLAVIVQLFIVFDLYKKEMVESKehflmsIKEGFSYIKR 226
Cdd:cd17324  123 RAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLG------LLSSLLLLLR 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 227 QHEIYGLMKIGLWVNFFASALFVSLPFIIIQNLHLSSKQLGVVEGMLAVGMLIGAIaLSVRKEVNNPFCSVYIGLFLFAG 306
Cdd:cd17324  197 NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSP-LAGRLADRGGRRALLIALLLLAA 275

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 446425264 307 LSLCtvFPLLVTIPKVVsfmyyIAFMILTGISMMAVNIPMQV 348
Cdd:cd17324  276 ALLL--LTLLGPSPLLL-----LVGLVLWGLGFFAAHSALQT 310
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
14-397 1.82e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 52.56  E-value: 1.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  14 KIATRNIILMMIGKMTSLLGAGIYTFAMGLYV--LKTTGSGMGFATTLicGSIPRMICGPIAGAVADRVNRKWLVIGTDL 91
Cdd:COG2271    6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQadLGLSAAQLGLLASA--FFLGYALGQIPAGLLADRFGRRRVLAIGLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  92 LSSLtmlimFILATTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVF 171
Cdd:COG2271   84 LWGL-----ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 172 GFFSIKSFFLLNSI----------------TFFLAVIVQLFIVFdlykkemveskehflmsikegfsyikrqheiyglmk 235
Cdd:COG2271  159 AAFGWRAAFLILGLpglllallrfwllalaYFLVYFALYGFLTW------------------------------------ 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 236 iglwvnffasalfvsLPFIIIQNLHLSSKQLGVVEGMLAVGMLIGAIA---LSVRkeVNNPFCSVYIGLFLFAGLSlctv 312
Cdd:COG2271  203 ---------------LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLggwLSDR--LGRRRKLVLAIGLLLAALA---- 261

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 313 fplLVTIPKVVSFMYYIAFMILTGISMMAVNIPMQVHLQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDMLPTSI 392
Cdd:COG2271  262 ---LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338


                 ....*
gi 446425264 393 VMMTI 397
Cdd:COG2271  339 AFLLL 343
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 63-343 5.63e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 51.42  E-value: 5.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  63 SIPRMICGPIAGAVADRVNRKWLvigtdLLSSLTMLIMFILATTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDE 142
Cdd:cd17474   44 TLPAAVLMPVAGVLADRFGRKKV-----LLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEG 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 143 ERIQKASALNQTAASLSNILAPIIGGVVfGFFSIKSFFLLNSITFFLAVIVQLFIVfdlykKEMVESKEHFLMSIKEGFS 222
Cdd:cd17474  119 GERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAFLAILFLL-----PEPKEKAKSSSATKLRDLK 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 223 YIKRQHEIYGLMKIGLWVNFFASALFVSLPFIIIQNLHLSSKQLGVVEGMLAVGMLIGAIALSVRKEVNNPFCSVYIGLF 302
Cdd:cd17474  193 KALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGL 272

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 446425264 303 LFAGLSLCtVFPLLVTIPKVVSFMyyIAFMILTGISMMAVN 343
Cdd:cd17474  273 LLYALSLL-LLGFVPSLALLLIAI--VLFGLGLGLNLPLLT 310
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 67-337 6.36e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.03  E-value: 6.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  67 MICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMFILattfgPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQ 146
Cdd:cd17473   49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFL-----DSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERA 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 147 KASALNQTAASLSNILAPIIGGVVfGFFSIKSFFLLnsitFFLAVIVQLFIVFDLYKKEMVESKEHFLMSIKEGFSYIKR 226
Cdd:cd17473  124 KMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRAPFLV----YLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKR 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 227 QHEIYGLMKIGLWVNFfasALFVSLPFIIIQNLHLSSKQLGVVEGMLAVGMLIGAIALS-VRKEVNNPFCSVYIGLFLFA 305
Cdd:cd17473  199 VLPIYFLAFLAMLLFY---VIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGrLKRRLGKRRLLAIGFALMAL 275

                        250       260       270
                 ....*....|....*....|....*....|..
gi 446425264 306 GLSLCTVFPLLVTIpkvvsfmyyIAFMILTGI 337
Cdd:cd17473  276 GFLLLALASGLWVV---------LLGAILAGL 298
MFS_CsbX cd17337
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ...
 67-197 1.52e-06

CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340895 [Multi-domain]  Cd Length: 388  Bit Score: 49.81  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  67 MICGPIAGAVADRVNRKWLVI--GTdLLSSLTMLIMFILATTFGPSLLFIYVSAALLSICASFYsVALTSSIPNLVDEER 144
Cdd:cd17337  258 IFFNLIFGILGDKIGWRRTVRwfGG-VGCAISTLLFYYVPQLFGHNYWAALIAAILFGIGLAGF-VPLSALMPSLAPEHK 335

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446425264 145 IQKASALNqTAASLSNILAPIIGGVVFGFFSIKSFFLLNSITFFLAVIVQLFI 197
Cdd:cd17337  336 GAAMSILN-LGAGLSNFVGPAIVTLFLGSFGAGGVVWIFAGLYLLSAVLTLFL 387
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 32-197 2.52e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 49.13  E-value: 2.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  32 LGAGIYTFAMGLYVLKTTGSG--MGFATTLIcgSIPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMFilattFGP 109
Cdd:cd17489   10 LSFYLLLPVLPLYAHDLGGSEavAGLVVGLF--TLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL-----LAT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 110 SLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIKSFFLLNSITFFL 189
Cdd:cd17489   83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL 162


                 ....*...
gi 446425264 190 AVIVQLFI 197
Cdd:cd17489  163 ALLLVFLV 170
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 67-341 3.74e-06

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 48.76  E-value: 3.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  67 MICGPIAGAVADRVN------RKWLVIGTDLLSSLTMLIMFILATTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLV 140
Cdd:cd17332   49 AINDPLMGYLIDRTRsrwgrfRPWLLWGAIPLALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELT 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 141 D--EERIqKASALNQTAASLSNILAPIIGGVVFGFFS----IKSFFLLNSITFFLAVIVQLFIVFDLYKKEMVESKEHFL 214
Cdd:cd17332  129 DdpEERT-SLTSWRMFFATIGGLLVTVLPPPLVAYFGggnaSRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSK 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 215 MSIKEGFSYIK--RQHEIYGLMKIGLWVNFFasALFVSLPFIIIQNL--HLSSKQLGVVEGMLAVGMLIGAIALSVRKEV 290
Cdd:cd17332  208 LPLLKSLKALLknRPFLILLLAYLLYFLAFN--IVNTVLVYYFKYVLggRAELVLLLLLILSGALLALLPWPPLKKRFGK 285

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446425264 291 NNPFCSVyIGLFLFAGLSLCTVFPLLVTIPKVVSFMYYIAFMILTGI--SMMA 341
Cdd:cd17332  286 KKAFFIG-LLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLpwAMLA 337
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 51-287 1.60e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 46.87  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  51 SGMGFATTLICGsiprMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMfilatTFGPSLLFIYVSAALLSICASFYSV 130
Cdd:cd17391   38 SGLAFSSTFLVS----AIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLM-----AFVTNVWQLLILRLLQGVFSGYVPN 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 131 ALTSsIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIKSFFLLNSITFFLAVIVQLFIVFDLYKKEMVESK 210
Cdd:cd17391  109 ATAL-IASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKM 187

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446425264 211 EHFlmsiKEGFSYIKRQHEIYGLMKIGLwVNFFASALFVSLPFIIIQNLHLSSKQLGVVEGMLAVGMLIGAIALSVR 287
Cdd:cd17391  188 VST----KEVWNSVPNPSLLISLFVTTF-IIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSATGVSSLLSAPR 259
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 61-386 2.81e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 46.03  E-value: 2.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  61 CGSIPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMFilattFGPSLLFIYVSAALLSICASFYSVAlTSSIPNLV 140
Cdd:cd17330   42 SYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG-----LSRNLWLLFLARFLDGLTGGNVSVA-QAYIADIT 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 141 DEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIKSFFLLNSITFFLAVIVQLFIVFDLykkemveskehflmsikeg 220
Cdd:cd17330  116 DEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPL------------------- 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 221 fsyikrqheiYGLMKIGLWVNFFASALFVSLPFIIIQNLHLSSKQLGVVEGMLAVGMLI--GAIALSVRKEVNNpfcsvy 298
Cdd:cd17330  177 ----------RRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILaqLLLIPRLAKRLGE------ 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 299 IGLFLFAGLSLCTVFPLLVTIPKVVSFMYyiaFMILTGISMMAVNIPMQVHLQKTTDPSYLGRVFGLLETIATAIAPLGM 378
Cdd:cd17330  241 RKLLRLGLLLAIIGLLLLPFASSVPLLVL---AAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGP 317


                 ....*...
gi 446425264 379 IVYGLLLD 386
Cdd:cd17330  318 LLAGPLYS 325
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
19-203 3.13e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 45.63  E-value: 3.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  19 NIILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTL-ICGSIPRMICGPIAGAVADRVNRKWLVIgtdLLSSLTM 97
Cdd:COG2271  181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLlSLPFLAGIVGSLLGGWLSDRLGRRRKLV---LAIGLLL 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  98 LIMFILATTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIK 177
Cdd:COG2271  258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337

                        170       180
                 ....*....|....*....|....*.
gi 446425264 178 SFFLLNSITFFLAVIVQLFIVFDLYK 203
Cdd:COG2271  338 AAFLLLAALALLAALLALLLLRETRK 363
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 18-197 3.66e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 45.65  E-value: 3.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  18 RNIILMMIGkmTSLLGAGIYTFAMGLYVL----KTTGSGMGFATT---LICGSIPRMICGPIAGAVADRVNRKWLVIgtd 90
Cdd:cd17504  177 RNVLLANIT--ALLAGFGMFMVFQLLPQLlqlpTPTGFGLGITEAgllLLPGALVMLIAGPLAGRLIARVGPRRVLL--- 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  91 lLSSLTMLIMFILATTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVV 170
Cdd:cd17504  252 -IGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 446425264 171 FGFFSIKSF-------------FLLNSITFFLAVIVQLFI 197
Cdd:cd17504  331 LTTYTVSITsggvptegayvlaFLIGAALALAALLLSLLI 370
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 72-339 4.77e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 45.26  E-value: 4.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  72 IAGAVADRVNRKwlvigTDLLSSLTMLIMFILATTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASAL 151
Cdd:cd17320   53 LYGPLSDRFGRR-----PVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 152 NQTAASLSNILAPIIGGVVFGFFSIKSFFLlnsITFFLAVIVQLFIVFDLYKKEMVESKEHFLMSIKEGFSYIKRQHEIY 231
Cdd:cd17320  128 LMMILAIAPALAPLLGGLLLLFFGWRAIFV---FLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFL 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 232 GLMKIGLWVNFFASALFVSLPFIIIQNLHLSSKQLGVVEGMLAVGMLIGAIALSVRKEVNNPFCSVYIGLFLFAglsLCT 311
Cdd:cd17320  205 GYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLL---AAA 281

                        250       260
                 ....*....|....*....|....*...
gi 446425264 312 VFPLLVTIPKVVSFMYYIAFMILTGISM 339
Cdd:cd17320  282 LVLLLAALLGGLSLWPLVAPLFLIFFGF 309
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 15-174 1.12e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 44.09  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  15 IATRNIILMMIGKMTSLLGAGIYTFAMGLY---VLKTTGSGMGFAttLICGSIPRMICGPIAGAVADRVNRKWLVIGTDL 91
Cdd:cd17321  165 LLARTFSGAVLAAFLLGAALGGLLFLLPLYlqgVLGYSPLQAGLA--LLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  92 LSSLTMLIMFILATTFGPSLLFIYVsaALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVF 171
Cdd:cd17321  243 LTAVGLLLLALLGADSSVWLLLPGL--VLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALL 320


                 ...
gi 446425264 172 GFF 174
Cdd:cd17321  321 TAG 323
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 20-198 1.13e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 44.18  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  20 IILMMIGKMTSLLGAGIYTFAMGLYV--LKTTGSGMGFATTLICGS--IPRMICGPIAGAVADRVNRKWLVIGTDLLSSL 95
Cdd:cd17391  203 LISLFVTTFIIQLANQSIEPILTLYIrqLMGDASNLAFISGLVFSAtgVSSLLSAPRLGKLGDRIGHHRILLGALLASAL 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  96 tmlIMFILATTFGPSLLFIYVSAALLSICASFYSValTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFS 175
Cdd:cd17391  283 ---LYIPQAFVQTPWQLGILRFLLGLATGGLLPAI--NSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFG 357

                        170       180
                 ....*....|....*....|...
gi 446425264 176 IKSFFLLNSITFFLAVIVQLFIV 198
Cdd:cd17391  358 YRAVFVVTALLVLLNAIWSFIFL 380
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 15-197 1.13e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.14  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  15 IATRNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSG-MGFATTLICGSIPRMICGPIAGAVADRVNRKWLVIGtdlls 93
Cdd:cd06173  205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGaAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLI----- 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  94 SLTMLIMFILATTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGF 173
Cdd:cd06173  280 GALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA 359

                        170       180
                 ....*....|....*....|....
gi 446425264 174 FSIKSFFLLNSITFFLAVIVQLFI 197
Cdd:cd06173  360 LGLSAVFLLAGALLLLAALLLLLL 383
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 21-143 1.22e-04

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 44.21  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  21 ILMMIGkMTSLLGAGIYTFAMGLYVLKTTGSGM----GFATTLICGSIpRMICGPIAGAVADRVNRKWLVIGTDLLSSLT 96
Cdd:cd17367  225 LLLVVG-LTAGGTLAFYTWTTYLQKFLVNTAGFskgdATWITTAALLV-FMLLQPLGGRLSDRIGRRPLLLFFGIGGTLA 302

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446425264  97 M-LIMFILATTFGPSLLFIYVSAALLSIcaSFYsvaltSSIPNLVDEE 143
Cdd:cd17367  303 TvPLLSALDHTDSPYTAFALVLVGLVFL--SGY-----TSINAVVKAE 343
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 67-198 1.37e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 43.74  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  67 MICGPIAGAVADRVNRKWLVIgtdllSSLTMLIMFILATTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQ 146
Cdd:cd17489  241 LLSRPFSGKLSDRKGPKTVII-----PGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRG 315

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446425264 147 KASALNQTAASLSNILAPIIGGVVFGFFSIKSFFLLNSITFFLAVIVQLFIV 198
Cdd:cd17489  316 AANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 71-394 1.59e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 43.70  E-value: 1.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  71 PIAGAVADRVNRKWLVIGTDLLSSLTMLIMFilattFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASA 150
Cdd:cd17321   49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCA-----LAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALG 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 151 LNQTAASLSNILAPIIGGVVFGFFSIKSFFLLNsitFFLAVIVqlfivfdlykkemveskehFLMSIKEGFSYIkrqhei 230
Cdd:cd17321  124 LWGAVVGIGAALGPLLGGLLLELFGWRWIFLIN---VPIGLVA-------------------LLLARTFSGAVL------ 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 231 yglmkIGLWVNFFASALFVSLPFIIIQNLHLSSKQLGVVEGMLAVGMLIGAI---ALSVRKEvnnpfcsvyIGLFLFAGL 307
Cdd:cd17321  176 -----AAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPlagRLADRFG---------PRLVLVAGL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 308 SLCTV-FPLLVTIPKVVSFMYYIAFMILTGISMMAVNIPMQVHLQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLD 386
Cdd:cd17321  242 LLTAVgLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLT 321


                 ....*...
gi 446425264 387 MLPTSIVM 394
Cdd:cd17321  322 AGLSANLG 329
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 91-193 1.61e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 43.34  E-value: 1.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  91 LLSSLTMLIMFILaTTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVV 170
Cdd:cd17330  245 RLGLLLAIIGLLL-LPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL 323

                         90       100
                 ....*....|....*....|...
gi 446425264 171 FGFFSIKSFFLLNSITFFLAVIV 193
Cdd:cd17330  324 YSFLGPGVPFLLAAGLLLIALFL 346
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
52-387 2.07e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.33  E-value: 2.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  52 GMGFATTLICGSIPRmicgPIAGAVADRVN-RKWLVIGTDLLSSLTMLImfilatTFGPSLLFIYVSAALLSICASFYSV 130
Cdd:COG2223   43 GLLFAIPVLVGALLR----IPLGFLVDRFGpRRVLLIGLLLLGIGLLLL------ALAVSYWLLLLLGLLLGIGGGGSFA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 131 ALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFFSIKSFFLLNSITFFLAVIVQLFIVFDLYKKEMVESK 210
Cdd:COG2223  113 VGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 211 EHFLmsikeGFSYIKRQHEIYGLMkIGLWVNFFA-SALFVSLPFIIIQNLHLSSKQLGVVEGMLAVGMLIGAI---ALSV 286
Cdd:COG2223  193 ASLR-----DQLEALRDPRFWLLS-LLYFGTFGSfIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPlggWLSD 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 287 RkevnnpFCSVYIGLFLFAGLSLCTVFPLLVTIpkvvSFMYYIAFMILTGISMMAVNIPMQVHLQKTTDPSYLGRVFGLL 366
Cdd:COG2223  267 R------IGGRRVLLIVFALMALGLLLLALALG----SLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLV 336

                        330       340
                 ....*....|....*....|.
gi 446425264 367 ETIATAIAPLGMIVYGLLLDM 387
Cdd:COG2223  337 GAAGGLGGFLGPLLFGALLDA 357
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 74-397 5.73e-04

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 41.82  E-value: 5.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  74 GAVADRVNRKWLVIGTdllssltmLIMFILAT---TFGPSLLFIYVSAALLSICAsfYSVALTSSIPNLVDEERIQKASA 150
Cdd:cd17472   53 GLLSDRIGRKPVILFG--------LLLFIAGSllaAYATSIYGLILGRALQGSGA--ISSVVMALLADLTREENRTKAMA 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 151 LNQTAASLSNILAPIIGGVVFGFFSIKSFFLLNSITFFLAVIVQLFIVfdlykKEMVESKEHFLMSIKEgFSYIKRQHEI 230
Cdd:cd17472  123 LIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFV-----PDPPKIVQISEKEKKK-LKKLLKNKRL 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 231 YGLMKIGLWVNFFASALFVSLPFIIIQNLHLSSKQLGVVEGMLAVGMLIGAIALSVRKEVNNPFCSVYIGLFLFAglslc 310
Cdd:cd17472  197 LRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSILLIA----- 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 311 tvFPLLVTIPKVVSFMYYIAFMILTGISMMAVNIPMQVHLQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDMLPT 390
Cdd:cd17472  272 --VGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGY 349


                 ....*..
gi 446425264 391 SIVMMTI 397
Cdd:cd17472  350 SSVFLTI 356
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 17-196 6.15e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 41.82  E-value: 6.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  17 TRNIILMMIGKMTSLLGAGIYTFAMGLYV---LKTTGSGMGFATTLIcGSIPRMICGPIAGAVADRVNRKWLVIGTDLLS 93
Cdd:cd17331  206 LPGVAFLLLVKLLSGLPIGMFQSMFSLVAmdfFGLTPEENGYLMSYA-GVLGMVVQGLLVGPLTKRFGERSLLKLSVALL 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  94 SLTMLIMFILATTFgpsllFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGF 173
Cdd:cd17331  285 AIGYLLLAFVTTVW-----QLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQA 359

                        170       180
                 ....*....|....*....|...
gi 446425264 174 FSIKSFFLLNSITFFLAVIVQLF 196
Cdd:cd17331  360 YGFPSFGLLGAAINGLLTVYLLL 382
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 68-378 8.59e-04

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 41.47  E-value: 8.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  68 ICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMFilattFGPSLLFIYVSAALLSICASFYSVAlTSSIPNLVDEERIQK 147
Cdd:cd17388   53 IFAPILGALSDRFGRRPVLLLSLAGAALDYLLMA-----FAPTLWWLYLGRIIAGITGATGAVA-AAYIADVTPPEQRAR 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 148 ASALNQTAASLSNILAPIIGGvVFGFFSIKSFFLLNSITFFLAVIVQLFIVFDLYKKEMVESKEHFLMSIKEGFSYIKRQ 227
Cdd:cd17388  127 NFGLLGAAFGLGFIAGPALGG-LLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGF 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 228 HEIYGLMKIGLWVNFFASALFVSLPFIIIQNLHLSSKQLGV---VEGMLAV---GMLIGAIA--LSVRKevnnpfcSVYI 299
Cdd:cd17388  206 PGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLslaVFGLLHAlfqAFVTGPIAkrLGEKR-------AILL 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 300 GLFLFaglslCTVFPLLVTIPKvvSFMYYIAFMILT--GISMMAvnipMQVHLQKTTDPSYLGRVFGL---LETIATAIA 374
Cdd:cd17388  279 GLAAD-----ALGFLLLAFATQ--GWMVFPILILLAlgGIAGPA----LQGLLSRQVPENEQGELQGVltsLTSLTSIIG 347


                 ....
gi 446425264 375 PLGM 378
Cdd:cd17388  348 PLLF 351
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 13-199 8.91e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.00  E-value: 8.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  13 MKIATRNIILMMIGKMTSLLGAGIYTFaMGLYVLKTTGSGMGFATTLICGSIPRMICGPIAGAVADRVNRKWLVIGTdll 92
Cdd:cd17477  184 RRLLRIAPLALLGAFVAGFLEGAFYSL-LPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGC--- 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  93 sSLTMLIMFILATTFGPSLLFIYVSAALLSICA-SFYSVALTsSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVF 171
Cdd:cd17477  260 -ALLGALAALLLPLVPGLPLALLVLLFLWGGAAgPLYTLALA-LAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALM 337

                        170       180
                 ....*....|....*....|....*...
gi 446425264 172 GFFSIKSFFllnsitFFLAVIVQLFIVF 199
Cdd:cd17477  338 DAFGPHGLF------LFLAAVALLFLLF 359
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
17-197 9.15e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 41.40  E-value: 9.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  17 TRNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLI-CGSIPRMICGPIAGAVADRVNRKWLVigtdLLSSL 95
Cdd:COG2223  204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAaLFALLGALGRPLGGWLSDRIGGRRVL----LIVFA 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  96 TMLIMFILATTFGPSLLFIYVSAALLSICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGVVFGFF- 174
Cdd:COG2223  280 LMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATg 359

                        170       180
                 ....*....|....*....|...
gi 446425264 175 SIKSFFLLNSITFFLAVIVQLFI 197
Cdd:COG2223  360 SYTAAFLVFAVLALVALVLTLLL 382
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 71-210 1.20e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 40.62  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  71 PIAGAVADRVNRKWLVIGTDLLSSLtmlimFILATTFGPSLLFIYVSAALLSICASFYSVAlTSSIPNLVDEERIQKASA 150
Cdd:cd17478   49 PLFGYLADRKPRRYLLPLGPLLTGL-----GLSLLGFAPNYWLLLLLVALAGIGSAAFHPE-GARLASQAAGGRRGLAMS 122

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 151 LNQTAASLSNILAPIIGGVVFGFFSIKSFFLLNSITfFLAVIVQLFIVFDLYKKEMVESK 210
Cdd:cd17478  123 IFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIP-GLAVALLLLRLRPLKKPEAKKAA 181
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 58-344 1.40e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 40.69  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  58 TLICGSIPRMICGPIAGAVADRVNRKWlviGTD----LLSSLTMLIMFIL---ATTFG---------PSLLFIYVSAALL 121
Cdd:cd17313   39 VWTLGPILGLFVQPLVGSLSDRCNSRI---GRRrpfiLVGAPLAALGLILipnAADIGlalgdgprtWALVLFVLGIVLL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 122 SICASFYSVALTSSIPNLVDEERIQKASALNQTAASLSNILAPIIGGV-----VFGFF---SIKSFFLLNSITFFLAVIV 193
Cdd:cd17313  116 DFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAIlwdhnWFGFAlggNLKVPFYIGAIILLVCVLV 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 194 QLFIV----FDLYKKEMVESKEHFLM--SIKEGFSYIKRqHEIYGLMKIGL-WVNFFASALFVSL--PFIIIQNLHLSSK 264
Cdd:cd17313  196 TLFFVkeppLSPEAGEHSENPSLGEVlkSLLKLLKIMPR-SLLRLLLVIFFwWIAFFPFELFFTDymGEEVYHGTSAASS 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 265 QLGVVEGMLAVGMLIGAIALSVRKEVNNPFCSvYIG---LFLFAGLSLCTVFPLLVTIPKVVSFMyyiAFMILTGISMMA 341
Cdd:cd17313  275 HYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGK-KIGrkkVYLIGLVLFAVGMALMALVHNVTVAL---VLFALGGIGWAT 350


                 ...
gi 446425264 342 VNI 344
Cdd:cd17313  351 INI 353
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 18-198 1.51e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 40.28  E-value: 1.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  18 RNIILMMIGkMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTL---ICGSIPRMICGPIAGAVADRVNRKWLVIGTDLLSS 94
Cdd:cd17316  176 RRRTLLLIL-LWFFISFGYYGLTTFLPTYLQTVLGLSPATSSlylLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  95 LTMLIMFILATTfgpSLLFIYVSAALLSICASFYSVALTSSIPNLVDEEriQKASALNqTAASLSNILApIIGGVVFGFF 174
Cdd:cd17316  255 ILALPLFYLLSG---SPTLLLLLLFILSFFVGGVWGALYAYLAELFPTE--VRATGVG-LSYNLGRLGG-GGAPPLIALL 327

                        170       180
                 ....*....|....*....|....
gi 446425264 175 SIKSFFLLNSITFFLAVIVQLFIV 198
Cdd:cd17316  328 LASTGGTGVPALILALLAIVALIV 351
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 72-397 2.49e-03

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 39.95  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264  72 IAGAVADRVNRKWLVIGTDLLSSLTMLIMfilatTFGPSLLFIyvsAALLSICASFYSVALTSSIPNLV----DEERIQK 147
Cdd:cd17312   57 ISGFLSDRSNIRRFMSAGLLLSALANIFM-----GFSTSLWFF---AVLWGLNGLFQSMGWPPCVKLLGnwfsKKERGTV 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 148 ASALNqTAASLSNILAPIIGGVVFGFFSIKSFFLLNSITFFLAVIVQLFIVFDlykkemvESKEHFLMSIKEGFSYIKRq 227
Cdd:cd17312  129 YGIWS-TSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRD-------SPPYVWVLSLAYAFVYIVR- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 228 heiyglmkiglwvnffaSALFVSLPFIIIQNLHLSSKQLGVVEGMLAVGMLIGAIALSVRKEVNNPFCSVYIGLFLFAGL 307
Cdd:cd17312  200 -----------------YACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLM 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425264 308 SLCTVFPLLVTIPKVVS--FMYYIAFMILTGISMMAVNIPMQVHLQKTtdpsyLGRVFGLLETIATAIAPLGMIVYGLLL 385
Cdd:cd17312  263 TLSLALFWFFPHNKLLSivLLFLIGFFVGGPINLIGGAAAQDIGRKEA-----AGTATGFVGLFGYLGASLAGLPLGYII 337

                        330
                 ....*....|..
gi 446425264 386 DMLPTSIVMMTI 397
Cdd:cd17312  338 DHYGWSTVFYFL 349
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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