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Conserved domains on  [gi|446425271|ref|WP_000503126|]
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MULTISPECIES: MFS transporter [Bacillus]

Protein Classification

MFS transporter( domain architecture ID 12947616)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 22-396 1.08e-70

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 227.50  E-value: 1.08e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  22 LMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:cd06173    3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 102 ILATIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQSFFL 181
Cdd:cd06173   83 LLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 182 LNSITFFLAVILQLFIVFDLyKKEVAESKEHFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVHTLHL 261
Cdd:cd06173  163 INALSFLLSALLLLFIRRPP-PAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 262 SSKQLGTVEGMLAVGMLMGAITLSVRKEVNNPFRSIYTGLFLFAGLSLCTVFpllvtipkVASFIYYIAFMMLTGIAIMI 341
Cdd:cd06173  242 GAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL--------SPSLWLLLAALFLLGLAGGL 313

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446425271 342 VNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDMLPTSIVMMT 396
Cdd:cd06173  314 FNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL 368
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 22-396 1.08e-70

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 227.50  E-value: 1.08e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  22 LMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:cd06173    3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 102 ILATIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQSFFL 181
Cdd:cd06173   83 LLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 182 LNSITFFLAVILQLFIVFDLyKKEVAESKEHFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVHTLHL 261
Cdd:cd06173  163 INALSFLLSALLLLFIRRPP-PAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 262 SSKQLGTVEGMLAVGMLMGAITLSVRKEVNNPFRSIYTGLFLFAGLSLCTVFpllvtipkVASFIYYIAFMMLTGIAIMI 341
Cdd:cd06173  242 GAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL--------SPSLWLLLAALFLLGLAGGL 313

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446425271 342 VNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDMLPTSIVMMT 396
Cdd:cd06173  314 FNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL 368
2A0121 TIGR00900
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
 22-388 3.12e-47

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162098 [Multi-domain]  Cd Length: 365  Bit Score: 165.57  E-value: 3.12e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271   22 LMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:TIGR00900   3 LLFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAVLP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  102 ILATIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQSFFL 181
Cdd:TIGR00900  83 FVALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAIW 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  182 LNSITFFLAVILQLFI-VFDLYKKEVAESKEHFLTSIKEGFSYVKRQHEIYGLMKIALWVNF-FACGLTVALPYIIVHTL 259
Cdd:TIGR00900 163 VDAVGFAISALLIVSVrIPELAASEIQALSNAVLRDTREGIKFVLKNPLLRTLLLLALLFNLvFAPAIVALFPYVQSKYL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  260 HLSSKQLGTVEGMLAVGMLMGAITLSV-RKEVNNPFrsIYTGLFLFAGLSLCTVFPLLVTIPkvasFIYYIAFMMltGIA 338
Cdd:TIGR00900 243 GRGSTHYGWVLAAFGLGALLGALLLGLlGRYFKRMA--LMTGAIFVIGLAILVVGLTPPNFP----LFLVLWFAI--GVG 314

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 446425271  339 IMIVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDML 388
Cdd:TIGR00900 315 YGPINVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLADHL 364
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-376 1.14e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 101.20  E-value: 1.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  18 RNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTM 97
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  98 LIMFilatiFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQ 177
Cdd:COG2814   90 LLCA-----LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 178 SFFLLNSITFFLAVILQLFIvfdlykkeVAESKEHFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVH 257
Cdd:COG2814  165 WVFLVNAVLALLALLLLLRL--------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 258 TLHLSSKQLGTVEGMLAVGMLMGAITLSVRKEVNNPFRSIYTGLFLFAGLSLCTVFpllvtipkVASFIYYIAFMMLTGI 337
Cdd:COG2814  237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL--------AGSLWLLLLALFLLGF 308

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 446425271 338 AIMIVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPL 376
Cdd:COG2814  309 GFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
23-378 2.59e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 76.69  E-value: 2.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271   23 MMIGKMTSLLGAGIYTFAMGLYVLKTTG-SGMGFATTLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  102 ilatiFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQSFFL 181
Cdd:pfam07690  81 -----FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  182 LNSITFFLAVILqLFIVFDLYKKEVAESKEHFLTSIKEGFSYVKRQHEIYGLmkIALWVNFFACGLTVALPYIIVHTLHL 261
Cdd:pfam07690 156 ILAILSLLAAVL-LLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLL--LALLLFGFAFFGLLTYLPLYQEVLGL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  262 SSKQLGTVEGMLAVGMLMGAITLSVRKEVNNPFRSIYTGLFLFAGLSLCTVFPLLVTipkvaSFIYYIAFMMLTGIAIMI 341
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTL-----SSLWLLLALLLLGFGFGL 307

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 446425271  342 VNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGM 378
Cdd:pfam07690 308 VFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
PRK10489 PRK10489
enterobactin transporter EntS;
25-391 4.42e-13

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 70.39  E-value: 4.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  25 IGKMTSLLGAGIYTFAMGLYVLKTTGSGM--GFATTLVCGSlprMICGPIAGAV-ADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:PRK10489  24 IARFISIFGLGLLGVAVPVQIQMMTGSTLqvGLSVTLTGGA---MFIGLMVGGVlADRYDRKKLILLARGTCGLGFIGLA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 102 ILATIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQSFFL 181
Cdd:PRK10489 101 LNAFLPEPSLLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPALGGLLIAAGGVAWNYG 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 182 LNSITFFLAVILqlfiVFDLYKKEVAESK-EHFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFAcGLTVALPYIIVHTLH 260
Cdd:PRK10489 181 LAAAGTFITLLP----LLRLPALPPPPQPrEHPLRSLLAGFRFLLASPVVGGIALLGGLLTMAS-AVRVLYPALADEVWQ 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 261 LSSKQLGTVEGMLAVGMLMGAITLSVRKEVNNPfrsiytGLFLFagLSLCTVFPLLVTIPKVASFIYYIAFMMLTGIAIM 340
Cdd:PRK10489 256 MGAAQIGLLYAAVPLGAALGALTSGWLAHSARP------GLLML--LSTLGSFLAVGLFGLMPMWILAVLCLALFGYLSA 327

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446425271 341 IVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDMLPTS 391
Cdd:PRK10489 328 ISSLLQYTLLQTQTPDEMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPV 378
 
Name Accession Description Interval E-value
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 22-396 1.08e-70

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 227.50  E-value: 1.08e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  22 LMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:cd06173    3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 102 ILATIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQSFFL 181
Cdd:cd06173   83 LLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 182 LNSITFFLAVILQLFIVFDLyKKEVAESKEHFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVHTLHL 261
Cdd:cd06173  163 INALSFLLSALLLLFIRRPP-PAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 262 SSKQLGTVEGMLAVGMLMGAITLSVRKEVNNPFRSIYTGLFLFAGLSLCTVFpllvtipkVASFIYYIAFMMLTGIAIMI 341
Cdd:cd06173  242 GAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL--------SPSLWLLLAALFLLGLAGGL 313

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446425271 342 VNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDMLPTSIVMMT 396
Cdd:cd06173  314 FNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL 368
2A0121 TIGR00900
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
 22-388 3.12e-47

H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162098 [Multi-domain]  Cd Length: 365  Bit Score: 165.57  E-value: 3.12e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271   22 LMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:TIGR00900   3 LLFAAQLISLIGTAITQVALPLYVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAVLP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  102 ILATIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQSFFL 181
Cdd:TIGR00900  83 FVALLGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAIW 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  182 LNSITFFLAVILQLFI-VFDLYKKEVAESKEHFLTSIKEGFSYVKRQHEIYGLMKIALWVNF-FACGLTVALPYIIVHTL 259
Cdd:TIGR00900 163 VDAVGFAISALLIVSVrIPELAASEIQALSNAVLRDTREGIKFVLKNPLLRTLLLLALLFNLvFAPAIVALFPYVQSKYL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  260 HLSSKQLGTVEGMLAVGMLMGAITLSV-RKEVNNPFrsIYTGLFLFAGLSLCTVFPLLVTIPkvasFIYYIAFMMltGIA 338
Cdd:TIGR00900 243 GRGSTHYGWVLAAFGLGALLGALLLGLlGRYFKRMA--LMTGAIFVIGLAILVVGLTPPNFP----LFLVLWFAI--GVG 314

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 446425271  339 IMIVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDML 388
Cdd:TIGR00900 315 YGPINVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLADHL 364
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-376 1.14e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 101.20  E-value: 1.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  18 RNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTM 97
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  98 LIMFilatiFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQ 177
Cdd:COG2814   90 LLCA-----LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 178 SFFLLNSITFFLAVILQLFIvfdlykkeVAESKEHFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVH 257
Cdd:COG2814  165 WVFLVNAVLALLALLLLLRL--------LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 258 TLHLSSKQLGTVEGMLAVGMLMGAITLSVRKEVNNPFRSIYTGLFLFAGLSLCTVFpllvtipkVASFIYYIAFMMLTGI 337
Cdd:COG2814  237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL--------AGSLWLLLLALFLLGF 308

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 446425271 338 AIMIVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPL 376
Cdd:COG2814  309 GFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 29-386 1.43e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 83.78  E-value: 1.43e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  29 TSLLGAGIYTFAMGLYVLKTTGSGMGFATTLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMfilatIFG 108
Cdd:cd17325    7 LDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF-----AFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 109 PSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQSFFLLNSITFF 188
Cdd:cd17325   82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 189 LAVILQLFIVFDlyKKEVAESKEHFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVHTLHLSSKQLGT 268
Cdd:cd17325  162 LALVLALLLLPE--PRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 269 VEGMLAVGMLMGAIT---LSVRKevnNPFRSIYTGLFLFAGlslctvfpLLVTIPKVASFIYYIAFMMLTGIAIMIVNIP 345
Cdd:cd17325  240 LFGAQGLASALSQPPagkLSDRI---GRKPLILIGLLLSAV--------ALLLLPLATSFWLLLLLLALLGLGLGLVFPA 308

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 446425271 346 MQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLD 386
Cdd:cd17325  309 TLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD 349
MFS_1 pfam07690
Major Facilitator Superfamily;
23-378 2.59e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 76.69  E-value: 2.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271   23 MMIGKMTSLLGAGIYTFAMGLYVLKTTG-SGMGFATTLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  102 ilatiFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQSFFL 181
Cdd:pfam07690  81 -----FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  182 LNSITFFLAVILqLFIVFDLYKKEVAESKEHFLTSIKEGFSYVKRQHEIYGLmkIALWVNFFACGLTVALPYIIVHTLHL 261
Cdd:pfam07690 156 ILAILSLLAAVL-LLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLL--LALLLFGFAFFGLLTYLPLYQEVLGL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  262 SSKQLGTVEGMLAVGMLMGAITLSVRKEVNNPFRSIYTGLFLFAGLSLCTVFPLLVTipkvaSFIYYIAFMMLTGIAIMI 341
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTL-----SSLWLLLALLLLGFGFGL 307

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 446425271  342 VNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGM 378
Cdd:pfam07690 308 VFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 20-397 8.88e-15

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 75.34  E-value: 8.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  20 IILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFA-TTLVCGSLPRMICGPIAGAVADRVNRKWLVigtdLLSSLTML 98
Cdd:cd17329    1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVgLVLALSAVAGIVASLIGGRLADRFGRKPVM----LAGLLLRA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  99 IMFILATIFGpSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFlSIQS 178
Cdd:cd17329   77 LGFALLGFAH-SPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 179 FFLLNSITFFLAVIlqlfIVFDLYKKEVAESKEHFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVHT 258
Cdd:cd17329  155 LFLAAAVLFLLAAL----VLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEI 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 259 LHLSSKQLG---TVEGMLAVGMLMGAITLSVRKevnNPFRSIYTGLFL----FAGLSLCTVFPLLVtipkVASFIYYIAF 331
Cdd:cd17329  231 LGLGESLLGlllALNALLIVLLQFPVARLVERF---RLRKILMIGILLfaigFAVLAFANTLAVLI----LAMIVLTLGE 303

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446425271 332 MMLTGIAIMIVNipmqvhmqKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDMLPTSIVMMTI 397
Cdd:cd17329  304 MLVFPAVQTLVA--------ALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLIL 361
PRK10489 PRK10489
enterobactin transporter EntS;
25-391 4.42e-13

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 70.39  E-value: 4.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  25 IGKMTSLLGAGIYTFAMGLYVLKTTGSGM--GFATTLVCGSlprMICGPIAGAV-ADRVNRKWLVIGTDLLSSLTMLIMF 101
Cdd:PRK10489  24 IARFISIFGLGLLGVAVPVQIQMMTGSTLqvGLSVTLTGGA---MFIGLMVGGVlADRYDRKKLILLARGTCGLGFIGLA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 102 ILATIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQSFFL 181
Cdd:PRK10489 101 LNAFLPEPSLLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPALGGLLIAAGGVAWNYG 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 182 LNSITFFLAVILqlfiVFDLYKKEVAESK-EHFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFAcGLTVALPYIIVHTLH 260
Cdd:PRK10489 181 LAAAGTFITLLP----LLRLPALPPPPQPrEHPLRSLLAGFRFLLASPVVGGIALLGGLLTMAS-AVRVLYPALADEVWQ 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 261 LSSKQLGTVEGMLAVGMLMGAITLSVRKEVNNPfrsiytGLFLFagLSLCTVFPLLVTIPKVASFIYYIAFMMLTGIAIM 340
Cdd:PRK10489 256 MGAAQIGLLYAAVPLGAALGALTSGWLAHSARP------GLLML--LSTLGSFLAVGLFGLMPMWILAVLCLALFGYLSA 327

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446425271 341 IVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDMLPTS 391
Cdd:PRK10489 328 ISSLLQYTLLQTQTPDEMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPV 378
MFS_3 pfam05977
Transmembrane secretion effector; This is a family of transport proteins. Members of this ...
 25-320 1.13e-12

Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.


Pssm-ID: 399164 [Multi-domain]  Cd Length: 523  Bit Score: 69.39  E-value: 1.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271   25 IGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMFILA 104
Cdd:pfam05977  17 IASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTLLTLLA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  105 TIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQSFFLLNS 184
Cdd:pfam05977  97 GLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPAFTFALNA 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  185 ITFF--LAVILQlfivfdlYKKEVAES---KEHFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVHTL 259
Cdd:pfam05977 177 LSYFavIAALWR-------WKRAAPASplpRERIFGAVRAGLRFTAMSRELRSVLVRAFAFGLSASAVWALLPLVARDLL 249

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446425271  260 HLSSKQLGTVEGMLAVGMLMGAITLSVRKEVNNPFRSIYTGLFLFAG--LSLCTVFPLLVTIP 320
Cdd:pfam05977 250 DGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALvlLSLALAPNLWLAIP 312
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 10-198 9.74e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 62.98  E-value: 9.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  10 DSRMKIATRNIILMMIGkmTSLLGAGIYTFAMGLYVLKTTGSGMGFAttlvCGSLPRMICGPIAGAVADRVNRKWLVIGT 89
Cdd:cd17325  198 DRRLLALFLAIFVLAFA--FGALEPFLPLYAAELGGLSPAQIGLLFG----AQGLASALSQPPAGKLSDRIGRKPLILIG 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  90 DLLSSLTMLIMfilatIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGV 169
Cdd:cd17325  272 LLLSAVALLLL-----PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGF 346

                        170       180
                 ....*....|....*....|....*....
gi 446425271 170 VFGFLSIQSFFLLNSITFFLAVILQLFIV 198
Cdd:cd17325  347 LYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 28-387 9.76e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 62.83  E-value: 9.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  28 MTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLVCGSLPRMICGPIAGAVADRVNRKWLvigtdLLSSLTMLIMFILATIF 107
Cdd:cd06174    6 FLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPV-----LLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 108 GPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSI--QSFFLLNSI 185
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwRAVFLIAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 186 TFFLAVILQLFIVFDLYKKEVAESKEHFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVHTLHLSSKQ 265
Cdd:cd06174  161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 266 LGTVEGMLAVGMLMGAITLSVRkeVNNPFRSIYTGLFLFAGLSLCTVFPLLVTipkvaSFIYYIAFMMLTGIAIMIVNIP 345
Cdd:cd06174  241 AGLLLSLFGLAGALGSLLLGLL--SDRLIGRKPLLLIGLLLMALGLALLLLAP-----SLLLLLLLLLLLGFGLGGLLPL 313

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 446425271 346 MQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGLLLDM 387
Cdd:cd06174  314 SFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
67-397 2.90e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 61.42  E-value: 2.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  67 MICGPIAGAVADRVNRKWLVIGTDLLSSLtmlimFILATIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQ 146
Cdd:COG2271   59 ALGQIPAGLLADRFGRRRVLAIGLLLWGL-----ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERG 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 147 KASALNQTAASLSNILGPIIGGVVFGFLSIQSFFLLNSITFFLAVILQLFIVFdlykkevaeskehfltsikegfsyvkr 226
Cdd:COG2271  134 RALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRFWLLA--------------------------- 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 227 qheiygLMKIALWVNFFacGLTVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAIT---LSVRkeVNNPFRSIYTGLFL 303
Cdd:COG2271  187 ------LAYFLVYFALY--GFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLggwLSDR--LGRRRKLVLAIGLL 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 304 FAGLSlctvfplLVTIPKVASFIYYIAFMMLTGIAIMIVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYGL 383
Cdd:COG2271  257 LAALA-------LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGY 329

                        330
                 ....*....|....
gi 446425271 384 LLDMLPTSIVMMTI 397
Cdd:COG2271  330 LLDATGYQAAFLLL 343
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 18-304 9.62e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 56.36  E-value: 9.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  18 RNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTM 97
Cdd:COG0477   14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  98 LIMFILatifgPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQ 177
Cdd:COG0477   94 LLCGLA-----PSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 178 SFFLLNSITFFLAVILQLFIVFDLYKKEVAESKEHFLTSIKEGFSYVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVH 257
Cdd:COG0477  169 WIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLL 248

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 446425271 258 TLHLSSKQLGTVEGMLAVGMLMGAITLSVRKEVNNPFRSIYTGLFLF 304
Cdd:COG0477  249 ALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
9-344 4.65e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 54.91  E-value: 4.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271   9 TDSRMKIATRNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLVcgSLPR---MICGPIAGAVADRVNRKW- 84
Cdd:COG2211    1 TAAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLIL--LVARlwdAITDPLIGALSDRTRTRWg 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  85 -----LVIGTdLLSSLTMLIMFiLATIFGPSLLFIY--ISAALLSICASFYSVALTSSIPNLVDEGRIQ-KASALNQTAA 156
Cdd:COG2211   79 rrrpwILIGA-IPLALSFVLLF-TAPDLSPTGKLIYalVTYLLLGLAYTLVNIPYSALGAELTPDYEERtRLSSWRFAFA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 157 SLSNILGPIIGGVVFGFLS---IQSFFLLNSITFFLAVILQLFIVFDLYKKEVAESKEhflTSIKEGFSYVKRQHE--IY 231
Cdd:COG2211  157 GLGGLLASVLPPPLVAAFGgdaALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEK---VSLKESLKALLKNRPflLL 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 232 GLMKIALWVNFFAcgLTVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAITLSV------RKEVnnpfrsiytglfLFA 305
Cdd:COG2211  234 LLAYLLFFLALAL--VAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRlakrfgKKKA------------FII 299

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 446425271 306 GLSLCTVFPLLVTIPKVASFIYYIAFMMLTGIAIMIVNI 344
Cdd:COG2211  300 GLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILV 338
MFS_CsbX cd17337
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ...
 67-197 1.20e-07

CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340895 [Multi-domain]  Cd Length: 388  Bit Score: 53.27  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  67 MICGPIAGAVADRVNRKWLVI--GTdLLSSLTMLIMFILATIFGPSLLFIYISAALLSICASFYsVALTSSIPNLVDEGR 144
Cdd:cd17337  258 IFFNLIFGILGDKIGWRRTVRwfGG-VGCAISTLLFYYVPQLFGHNYWAALIAAILFGIGLAGF-VPLSALMPSLAPEHK 335

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446425271 145 IQKASALNqTAASLSNILGPIIGGVVFGFLSIQSFFLLNSITFFLAVILQLFI 197
Cdd:cd17337  336 GAAMSILN-LGAGLSNFVGPAIVTLFLGSFGAGGVVWIFAGLYLLSAVLTLFL 387
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 73-362 3.25e-07

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 52.62  E-value: 3.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271   73 AGAVADRVNRKWLVIGTDLLSSLTMLIMfILATIFGPsLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALN 152
Cdd:PRK08633   67 AGFLADKFSKNRVIRIVKLFEVGLTLLI-VLAYYLGW-FWLAFAVTFLLGAQSAIYSPAKYGIIPELVGKENLSRANGLL 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  153 QTAASLSNILGPIIGGVVF-GFLSIQSFFLLNSITFFLAVIL-----QLFIVFDL------YKKEVAESKEHFLTSIKEG 220
Cdd:PRK08633  145 EAFTIVAILAGTALFSFLFeSVNGNTPSEILGRIAPAGLVLLavavlGLIFAYRLpkvpaaAPEVFDKKKYLFPKLLWRN 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  221 FSYVKRQHEIYgLMKIAL-WVNFFACGLTVALPYIIVHTLHLS-SKQLGTVEGMLAVGMLMGAIT---LSVRKevnnpfr 295
Cdd:PRK08633  225 LKLLRSDRVLW-LAIIGLsYFWFISQLAQANFPAYAKEVLGLDnTFQVQYLLAASAIGIGIGSLLagrLSGRH------- 296

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446425271  296 sIYTGLFLF--AGLSLCTVFpllvtIPKVASFIYYIAFMMLTGIAIMIVNIPMQVHMQKTTDPSYLGRV 362
Cdd:PRK08633  297 -IELGLVPLgaLGLALSLFL-----LPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGKV 359
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 63-393 3.98e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 51.80  E-value: 3.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  63 SLPRMICGPIAGAVADRVNRKWLvigtdLLSSLTMLIMFILATIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDE 142
Cdd:cd17474   44 TLPAAVLMPVAGVLADRFGRKKV-----LLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEG 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 143 GRIQKASALNQTAASLSNILGPIIGGVVfGFLSIQSFFLLNSITFFLAVILQLFIVfdlykKEVAESKEHFLTSIKEGFS 222
Cdd:cd17474  119 GERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAFLAILFLL-----PEPKEKAKSSSATKLRDLK 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 223 YVKRQHEIYGLMKIALWVNFFACGLTVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAITLSVRKEVNNPFRSIYTGLF 302
Cdd:cd17474  193 KALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGL 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 303 LFAGLSLCtVFPLLVTIPKVasfiyyIAFMMLTGIAIMIVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVYG 382
Cdd:cd17474  273 LLYALSLL-LLGFVPSLALL------LIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFG 345

                        330
                 ....*....|.
gi 446425271 383 LLLDMLPTSIV 393
Cdd:cd17474  346 LLLEIFGLSAP 356
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 32-197 4.01e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.83  E-value: 4.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  32 LGAGIYTFAMGLYVLKTTGSG--MGFATTLVcgSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMfilatIFGP 109
Cdd:cd17489   10 LSFYLLLPVLPLYAHDLGGSEavAGLVVGLF--TLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY-----LLAT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 110 SLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQSFFLLNSITFFL 189
Cdd:cd17489   83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL 162


                 ....*...
gi 446425271 190 AVILQLFI 197
Cdd:cd17489  163 ALLLVFLV 170
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 67-344 1.79e-06

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 49.91  E-value: 1.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  67 MICGPIAGAVADRVN------RKWLVIGTDLLSSLTMLIMFILATIFGPSLLFIYISAALLSICASFYSVALTSSIPNLV 140
Cdd:cd17332   49 AINDPLMGYLIDRTRsrwgrfRPWLLWGAIPLALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELT 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 141 DEGRIQ-KASALNQTAASLSNILGPIIGGVVFGFLS----IQSFFLLNSITFFLAVILQLFIVFDLYKKEVAESKEHFLT 215
Cdd:cd17332  129 DDPEERtSLTSWRMFFATIGGLLVTVLPPPLVAYFGggnaSRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKL 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 216 SIKEGFSYVK--RQHEIYGLMKIALWVNFFAcgLTVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAITLSVRKEVNNP 293
Cdd:cd17332  209 PLLKSLKALLknRPFLILLLAYLLYFLAFNI--VNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKK 286

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446425271 294 frsiytgLFLFAGLSLCTVFPLLVTIPKVASFIYYIAFMMLTGIAIMIVNI 344
Cdd:cd17332  287 -------KAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANL 330
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 67-348 2.23e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 49.47  E-value: 2.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  67 MICGPIAGAVADRVNRKWLvigtdLLSSLTMLIMFILATIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQ 146
Cdd:cd17324   48 ALGALLLGPLSDRIERRRL-----LLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRG 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 147 KASALNQTAASLSNILGPIIGGVVFGFLSIQSFFLLNSITFFLAVILQLFIVFDLyKKEVAESKEHFLTSIKEGFSYVKR 226
Cdd:cd17324  123 RAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSL-PPKKPGSLGLLSSLLLLLRNPRLR 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 227 QHEIYGLMKIALWVNFFACgltvaLPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAiTLSVRKEVNNPFRSIYTGLFLFAG 306
Cdd:cd17324  202 LAYLITFLLFGGFFALYTY-----LAPFLTDVPGFSSSAIIGLLLLFGVAGVVGS-PLAGRLADRGGRRALLIALLLLAA 275

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 446425271 307 LSLCtvFPLLVTIPKVAsfiyyIAFMMLTGIAIMIVNIPMQV 348
Cdd:cd17324  276 ALLL--LTLLGPSPLLL-----LVGLVLWGLGFFAAHSALQT 310
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 67-366 1.33e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 46.80  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  67 MICGPIAGAVADRVNRKWLVIGTDLLSSLtmlimFILATIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQ 146
Cdd:cd17473   49 ALFAPLAGWLADRFGRKRLLIAGLLLYGI-----GGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERA 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 147 KASALNQTAASLSNILGPIIGGVVfGFLSIQSFFLLnsitFFLAVILQLFIVFDLYKKEVAESKEHFLTSIKEGFSYVKR 226
Cdd:cd17473  124 KMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRAPFLV----YLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKR 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 227 QHEIYGLMKIALWVNFfacGLTVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAITLS-VRKEVnnPFRSIYTGLFLFA 305
Cdd:cd17473  199 VLPIYFLAFLAMLLFY---VIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGrLKRRL--GKRRLLAIGFALM 273

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446425271 306 GLSlctvfplLVTIPKVASFIYYIAFMMLTGIAIMIVnIPMQVHM-QKTTDPSYLGRVFGLL 366
Cdd:cd17473  274 ALG-------FLLLALASGLWVVLLGAILAGLGFGLL-LPTLNSWaMSLVPPELRGRAMGIV 327
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 91-193 1.97e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 46.42  E-value: 1.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  91 LLSSLTMLIMFILaTIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVV 170
Cdd:cd17330  245 RLGLLLAIIGLLL-LPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL 323

                         90       100
                 ....*....|....*....|...
gi 446425271 171 FGFLSIQSFFLLNSITFFLAVIL 193
Cdd:cd17330  324 YSFLGPGVPFLLAAGLLLIALFL 346
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 51-287 2.77e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 46.10  E-value: 2.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  51 SGMGFATTLvcgsLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMFILATIFgpSLLFIYIsaaLLSICASFYSV 130
Cdd:cd17391   38 SGLAFSSTF----LVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVW--QLLILRL---LQGVFSGYVPN 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 131 ALTSsIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQSFFLLNSITFFLAVILQLFIVFDLYKKEVAESK 210
Cdd:cd17391  109 ATAL-IASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKM 187

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446425271 211 EHFltsiKEGFSYVKRQHEIYGLMkIALWVNFFACGLTVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAITLSVR 287
Cdd:cd17391  188 VST----KEVWNSVPNPSLLISLF-VTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSATGVSSLLSAPR 259
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
19-203 3.02e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 45.63  E-value: 3.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  19 NIILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLV-CGSLPRMICGPIAGAVADRVNRKWLVIgtdLLSSLTM 97
Cdd:COG2271  181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLsLPFLAGIVGSLLGGWLSDRLGRRRKLV---LAIGLLL 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  98 LIMFILATIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQ 177
Cdd:COG2271  258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337

                        170       180
                 ....*....|....*....|....*.
gi 446425271 178 SFFLLNSITFFLAVILQLFIVFDLYK 203
Cdd:COG2271  338 AAFLLLAALALLAALLALLLLRETRK 363
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 72-339 3.56e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 45.64  E-value: 3.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  72 IAGAVADRVNRKwlvigTDLLSSLTMLIMFILATIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASAL 151
Cdd:cd17320   53 LYGPLSDRFGRR-----PVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 152 NQTAASLSNILGPIIGGVVFGFLSIQSFFLlnsITFFLAVILQLFIVFDLYKKEVAESKEHFLTSIKEGFSYVKRQHEI- 230
Cdd:cd17320  128 LMMILAIAPALAPLLGGLLLLFFGWRAIFV---FLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFl 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 231 -YGLMKIALWVNFFACGltVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAITLSVRKEVNNPFRSIYTGLFLFAglsL 309
Cdd:cd17320  205 gYALALGLSFAGLFAYL--AAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLL---A 279

                        250       260       270
                 ....*....|....*....|....*....|
gi 446425271 310 CTVFPLLVTIPKVASFIYYIAFMMLTGIAI 339
Cdd:cd17320  280 AALVLLLAALLGGLSLWPLVAPLFLIFFGF 309
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
52-387 5.89e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.87  E-value: 5.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  52 GMGFATTLVCGSLPRmicgPIAGAVADRVNRKWLVIGTDLLSSLTMLIMFilatiFGPSLLFIYISAALLSICASFYSVA 131
Cdd:COG2223   43 GLLFAIPVLVGALLR----IPLGFLVDRFGPRRVLLIGLLLLGIGLLLLA-----LAVSYWLLLLLGLLLGIGGGGSFAV 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 132 LTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQSFFLLNSITFFLAVILQLFIVFDLYKKEVAESKE 211
Cdd:COG2223  114 GIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKA 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 212 HFLTSIKegfsyVKRQHEIYGLMkIALWVNFFA-CGLTVALPYIIVHTLHLSSKQLGTVEGMLAVGMLMGAI---TLSVR 287
Cdd:COG2223  194 SLRDQLE-----ALRDPRFWLLS-LLYFGTFGSfIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPlggWLSDR 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 288 kevnnpFRSIYTGLFLFAGLSLCTVFPLLVTipkvASFIYYIAFMMLTGIAIMIVNIPMQVHMQKTTDPSYLGRVFGLLE 367
Cdd:COG2223  268 ------IGGRRVLLIVFALMALGLLLLALAL----GSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVG 337

                        330       340
                 ....*....|....*....|
gi 446425271 368 TIATAIAPLGMIVYGLLLDM 387
Cdd:COG2223  338 AAGGLGGFLGPLLFGALLDA 357
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 34-198 7.80e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.51  E-value: 7.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  34 AGIYTFaMGLYVLKTTGSGMGFATTLVCGSLprMICGPIAGAVADRVNRKWLVIgtdllSSLTMLIMFILATIFGPSLLF 113
Cdd:cd17489  211 GAISTF-LPLYAAERGISNAGLFFTVYAIAL--LLSRPFSGKLSDRKGPKTVII-----PGLLLLALGLLLLSFAGSPWM 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 114 IYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQSFFLLNSITFFLAVIL 193
Cdd:cd17489  283 LLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362


                 ....*
gi 446425271 194 QLFIV 198
Cdd:cd17489  363 YIFLL 367
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 20-198 1.11e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 44.18  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  20 IILMMIGKMTSLLGAGIYTFAMGLYV--LKTTGSGMGFATTLVCGS--LPRMICGPIAGAVADRVNRKWLVIGTDLLSSL 95
Cdd:cd17391  203 LISLFVTTFIIQLANQSIEPILTLYIrqLMGDASNLAFISGLVFSAtgVSSLLSAPRLGKLGDRIGHHRILLGALLASAL 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  96 tmlIMFILATIFGPSLLFIYISAALLSICASFYSValTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLS 175
Cdd:cd17391  283 ---LYIPQAFVQTPWQLGILRFLLGLATGGLLPAI--NSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFG 357

                        170       180
                 ....*....|....*....|...
gi 446425271 176 IQSFFLLNSITFFLAVILQLFIV 198
Cdd:cd17391  358 YRAVFVVTALLVLLNAIWSFIFL 380
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 18-197 1.25e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 43.72  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  18 RNIILMMIGkmTSLLGAGIYTFAMGLYVL----KTTGSGMGFATT---LVCGSLPRMICGPIAGAVADRVNRKWLVIgtd 90
Cdd:cd17504  177 RNVLLANIT--ALLAGFGMFMVFQLLPQLlqlpTPTGFGLGITEAgllLLPGALVMLIAGPLAGRLIARVGPRRVLL--- 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  91 lLSSLTMLIMFILATIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVV 170
Cdd:cd17504  252 -IGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 446425271 171 ----------FGFLSIQSF---FLLNSITFFLAVILQLFI 197
Cdd:cd17504  331 lttytvsitsGGVPTEGAYvlaFLIGAALALAALLLSLLI 370
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 71-397 1.81e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 43.31  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  71 PIAGAVADRVNRKWLVIGTDLLSSLTMLIMFilatiFGPSLLFIYISAALLSICASFYSVAlTSSIPNLVDEGRIQKASA 150
Cdd:cd17478   49 PLFGYLADRKPRRYLLPLGPLLTGLGLSLLG-----FAPNYWLLLLLVALAGIGSAAFHPE-GARLASQAAGGRRGLAMS 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 151 LNQTAASLSNILGPIIGGVVfgflsIQSFFLLNSITFFLAVILQLFIVFDLYKKEVAESKEHFLTSIKEGFSYVKRQHEI 230
Cdd:cd17478  123 IFSVGGNLGFALGPLIAAAL-----VALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRAL 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 231 YGLMKIALWVNFFACGLTVALPYIIVHtlHLSSKQLGTVegMLAVGMLMGAITlsvrkevnnpfrSIYTGLF-------- 302
Cdd:cd17478  198 LLLLIIVFLRSWVLSSLTTFLPFYLVQ--RGYSLVFAGL--LLSLFLFAGAIG------------TLIGGPLsdrfgrrr 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 303 -LFAGLSLCTVFPLLVTipkVASFIYYIAFMMLTGIAIMiVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMIVY 381
Cdd:cd17478  262 vIIASLLLAAPFLLLFL---LTPGIWSYILLVLAGFLLF-ASFPVTVVLAQELLPGNVGLASGLMMGLSFGLGGIGAPVL 337

                        330
                 ....*....|....*.
gi 446425271 382 GLLLDMLPTSIVMMTI 397
Cdd:cd17478  338 GALADAFGLESVLLIL 353
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
17-197 3.00e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.56  E-value: 3.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  17 TRNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTLV-CGSLPRMICGPIAGAVADRVNRKWLVigtdLLSSL 95
Cdd:COG2223  204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAaLFALLGALGRPLGGWLSDRIGGRRVL----LIVFA 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  96 TMLIMFILATIFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFG-FL 174
Cdd:COG2223  280 LMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDaTG 359

                        170       180
                 ....*....|....*....|...
gi 446425271 175 SIQSFFLLNSITFFLAVILQLFI 197
Cdd:COG2223  360 SYTAAFLVFAVLALVALVLTLLL 382
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 15-174 4.22e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 42.16  E-value: 4.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  15 IATRNIILMMIGKMTSLLGAGIYTFAMGLY---VLKTTGSGMGFAttLVCGSLPRMICGPIAGAVADRVNRKWLVIGTDL 91
Cdd:cd17321  165 LLARTFSGAVLAAFLLGAALGGLLFLLPLYlqgVLGYSPLQAGLA--LLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  92 LSSLTMLIMFILATIFGPSLLFIYIsaALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVF 171
Cdd:cd17321  243 LTAVGLLLLALLGADSSVWLLLPGL--VLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALL 320


                 ...
gi 446425271 172 GFL 174
Cdd:cd17321  321 TAG 323
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 60-386 5.25e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 41.79  E-value: 5.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  60 VCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMFilatiFGPSLLFIYISAALLSICASFYSVAlTSSIPNL 139
Cdd:cd17330   41 SSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG-----LSRNLWLLFLARFLDGLTGGNVSVA-QAYIADI 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 140 VDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQSFFLLNSITFFLAVILQLFIVFDLYkkevaeskehfltsike 219
Cdd:cd17330  115 TDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLR----------------- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 220 gfsyvkrqheiyGLMKIALWVNFFACGLTVALPYIIVHTLHLSSKQLGTVegMLAVGMLMGAITLSVRKEVNNPFRSIYt 299
Cdd:cd17330  178 ------------RLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLL--LALVGIAGILAQLLLIPRLAKRLGERK- 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 300 gLFLFAGLSLCTVFPLLVTIPKVASFIYyiaFMMLTGIAIMIVNIPMQVHMQKTTDPSYLGRVFGLLETIATAIAPLGMI 379
Cdd:cd17330  243 -LLRLGLLLAIIGLLLLPFASSVPLLVL---AAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPL 318


                 ....*..
gi 446425271 380 VYGLLLD 386
Cdd:cd17330  319 LAGPLYS 325
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 17-196 1.12e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 41.05  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  17 TRNIILMMIGKMTSLLGAGIYTFAMGLYVLKTTG----------SGMGFATTLVCGSLprmicgpiAGAVADRVNRKWLV 86
Cdd:cd17331  206 LPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGltpeengylmSYAGVLGMVVQGLL--------VGPLTKRFGERSLL 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  87 IGTDLLSSLTMLIMFILATIFgpsllFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPII 166
Cdd:cd17331  278 KLSVALLAIGYLLLAFVTTVW-----QLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTI 352

                        170       180       190
                 ....*....|....*....|....*....|
gi 446425271 167 GGVVFGFLSIQSFFLLNSITFFLAVILQLF 196
Cdd:cd17331  353 GGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 21-129 1.31e-03

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 40.74  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  21 ILMMIGkMTSLLGAGIYTFAMGLYVLKTTGSGM----GFATTLVCGSLpRMICGPIAGAVADRVNRKWLVIGTDLLSSLT 96
Cdd:cd17367  225 LLLVVG-LTAGGTLAFYTWTTYLQKFLVNTAGFskgdATWITTAALLV-FMLLQPLGGRLSDRIGRRPLLLFFGIGGTLA 302

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446425271  97 M-LIMFILATIFGPSLLFIYISAALLSIcaSFYS 129
Cdd:cd17367  303 TvPLLSALDHTDSPYTAFALVLVGLVFL--SGYT 334
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 71-193 1.31e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 40.62  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  71 PIAGAVADRVNRKWLVIGTDLLSSLTMLIMFilatiFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASA 150
Cdd:cd17321   49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCA-----LAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALG 123

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446425271 151 LNQTAASLSNILGPIIGGVVFGFLSIQSFFLLNSITFFLAVIL 193
Cdd:cd17321  124 LWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL 166
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 18-198 1.36e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 40.66  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  18 RNIILMMIGkMTSLLGAGIYTFAMGLYVLKTTGSGMGFATTL---VCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSS 94
Cdd:cd17316  176 RRRTLLLIL-LWFFISFGYYGLTTFLPTYLQTVLGLSPATSSlylLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  95 LTMLIMFILatiFGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGriQKASALNqTAASLSNILGpIIGGVVFGFL 174
Cdd:cd17316  255 ILALPLFYL---LSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTE--VRATGVG-LSYNLGRLGG-GGAPPLIALL 327

                        170       180
                 ....*....|....*....|....
gi 446425271 175 SIQSFFLLNSITFFLAVILQLFIV 198
Cdd:cd17316  328 LASTGGTGVPALILALLAIVALIV 351
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
59-211 2.44e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.84  E-value: 2.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  59 LVCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMfilatIFGPSLLFIYISAALLSICASFYSVALTSSIPN 138
Cdd:COG0738   49 LFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF-----ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA 123

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446425271 139 LVDEGRIQKASALnQTAASLSNILGPIIGGVVFGF---LSIQSFFLLNSITFFLAVILQLFIVFDLYKKEVAESKE 211
Cdd:COG0738  124 LGPETAASRLNLL-HAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAG 198
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 74-343 2.53e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 39.90  E-value: 2.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  74 GAVADRVNRKWLVIGTDLLSSLTMLIMFILAtifgPSLLFIYISAALLSICASFYsVALTSSIPNLVDEGRIQKASALNQ 153
Cdd:cd17490   52 GILSDRIGKRKLFIIIGLLFTVLASLIMILF----PSPWGLLIARFLSGIAAATW-VSFTVLYASYFPPDEAAKAMGLIN 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 154 TAASLSNILGPIIGGVVFGFLSIQSFFLLNSITFFLAVILQLFIvfdlykKEVAESKEHFLTSIKEGFSYVKRQhEIYGL 233
Cdd:cd17490  127 LVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFI------KEERREKKPVLTELKELLSVLKDK-KLLFF 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 234 MKIALWVNFFACGLTVALPYIIVHTLHLSSKQLGTVEGM-LAVGMLMGAITLSVRKEVNNPFRSIYTGLFLFAGLSLCTV 312
Cdd:cd17490  200 SLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIyLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIP 279

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 446425271 313 F----PLLVTIPKVASFIYYIAFMMLTGIAIMIVN 343
Cdd:cd17490  280 FapnlTLLYLLQALNGFGTGILFPLLMSLSIEGVP 314
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 28-193 6.69e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 38.29  E-value: 6.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  28 MTSLLGAGIYTFAMGLYVLKTTGSGMGFATTL-VCGSLPRMICGPIAGAVADRVNRKWLVIGTDLLSSLTMLIMfilatI 106
Cdd:cd17370  208 AVALFALGNFSFAFLILRAQELGLSAALIPLLyALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGF-----A 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 107 FGPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRIQKASALNQTAASLSNILGPIIGGVVFGFLSIQSFFLLNSIT 186
Cdd:cd17370  283 LGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVL 362


                 ....*..
gi 446425271 187 FFLAVIL 193
Cdd:cd17370  363 ALIALLL 369
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 67-343 7.45e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 38.37  E-value: 7.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271  67 MICGPIAGAVADRVNRKW-LVIGTDLLSSLTMLIMFIlatifgPSLLFIYISAALLSICASFYSVALTSSIPNLVDEGRI 145
Cdd:cd17328   48 MVLSPIFGYLGDRYNRKWiLAVGILIWSAATLLSSFA------PNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKR 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 146 QKASALNQTAASLSNILGPIIGGVVFG-FLSIQSFFLLNSITFFLAVILQLFIVFDLYKKEVAESKEHFL--TSIKEGFS 222
Cdd:cd17328  122 TRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKStaTSFLADLK 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425271 223 YVKRQHeIYGLMKIALW-VNFFACGLTVALP---YIIVHTLHLSSKQLGTVEGMLA-----VGMLMGAItLSVRKEVNNP 293
Cdd:cd17328  202 ALAKNP-SFILSTLGFTaVSFVTGALAFWAPtffLRAFGVGDLSSADVGLIFGAITciagvLGVLLGGI-LADRLRRKTP 279

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 446425271 294 frsiYTGLFLFAGLSLCTVFPLLVTIPKVASFIYYIAFMMLTGIAIMIVN 343
Cdd:cd17328  280 ----RADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLN 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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