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Conserved domains on  [gi|446425970|ref|WP_000503825|]
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molybdenum cofactor biosynthesis protein B [Staphylococcus aureus]

Protein Classification

molybdenum cofactor biosynthesis protein B( domain architecture ID 10001646)

molybdenum cofactor biosynthesis protein B (MoaB) similar to Pyrococcus furiosus MoaB; may be a metal-binding pterin (MPT)-adenylyltransferase which converts MPT to adenylylated MPT (MPT-AMP)

CATH:  3.40.980.10
Gene Ontology:  GO:0006777
PubMed:  18154309|12504674
SCOP:  4000598

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MoaB COG0521
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin ...
 1-168 2.16e-70

Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin biosynthesis enzyme MoaB/MogA is part of the Pathway/BioSystem: Molybdopterin biosynthesis


:

Pssm-ID: 440287 [Multi-domain]  Cd Length: 169  Bit Score: 209.97  E-value: 2.16e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970   1 MGEHqnvKLNRTVKAAVLTVSDTRNF--DTDKGGQCVRQLLQADDVEVsdAHYTIVKDEKVAITTQVKKWL-EEDIDVII 77
Cdd:COG0521    1 MSSA---RAFVPLRIAVLTVSDRRSRgeREDTSGPALVELLEEAGHEV--VARRIVPDDKDAIRAALRELIdDEGVDLVL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970  78 TTGGTGIAQRDVTIEAVKPLLTKEIEGFGELFRYLSYvEDVGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKlIKP 157
Cdd:COG0521   76 TTGGTGLSPRDVTPEATRPLLDKELPGFGELFRALSL-EEIGPSAILSRAVAGIRGGTLIFNLPGSPGAVREALEA-ILP 153

                        170
                 ....*....|.
gi 446425970 158 ELNHLIHELTK 168
Cdd:COG0521  154 ELPHAVDLLNG 164
 
Name Accession Description Interval E-value
MoaB COG0521
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin ...
 1-168 2.16e-70

Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin biosynthesis enzyme MoaB/MogA is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440287 [Multi-domain]  Cd Length: 169  Bit Score: 209.97  E-value: 2.16e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970   1 MGEHqnvKLNRTVKAAVLTVSDTRNF--DTDKGGQCVRQLLQADDVEVsdAHYTIVKDEKVAITTQVKKWL-EEDIDVII 77
Cdd:COG0521    1 MSSA---RAFVPLRIAVLTVSDRRSRgeREDTSGPALVELLEEAGHEV--VARRIVPDDKDAIRAALRELIdDEGVDLVL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970  78 TTGGTGIAQRDVTIEAVKPLLTKEIEGFGELFRYLSYvEDVGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKlIKP 157
Cdd:COG0521   76 TTGGTGLSPRDVTPEATRPLLDKELPGFGELFRALSL-EEIGPSAILSRAVAGIRGGTLIFNLPGSPGAVREALEA-ILP 153

                        170
                 ....*....|.
gi 446425970 158 ELNHLIHELTK 168
Cdd:COG0521  154 ELPHAVDLLNG 164
MogA_MoaB cd00886
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum ...
 13-166 2.41e-64

MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MogA, together with MoeA, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes. In contrast, MoaB shows high similarity to MogA, but little is known about its physiological role. All well studied members of this family form highly stable trimers.


Pssm-ID: 238451 [Multi-domain]  Cd Length: 152  Bit Score: 194.23  E-value: 2.41e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970  13 VKAAVLTVSDTR--NFDTDKGGQCVRQLLQADDVEVsdAHYTIVKDEKVAITTQVKKWLEE-DIDVIITTGGTGIAQRDV 89
Cdd:cd00886    1 LRAAVLTVSDTRsaGEAEDRSGPALVELLEEAGHEV--VAYEIVPDDKDEIREALIEWADEdGVDLILTTGGTGLAPRDV 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446425970  90 TIEAVKPLLTKEIEGFGELFRYLSYvEDVGTrALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKlIKPELNHLIHEL 166
Cdd:cd00886   79 TPEATRPLLDKELPGFGEAFRALSL-EETGT-AMLSRAVAGIRGGTLIFNLPGSPKAVREALEV-ILPELPHLLDLL 152
moaC PRK03604
bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional
 4-164 9.14e-36

bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional


Pssm-ID: 235138 [Multi-domain]  Cd Length: 312  Bit Score: 126.21  E-value: 9.14e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970   4 HQNVKLNRTVKAAVLTVSDTRNFDT--DKGGQCVRQLLQADDVEVSdaHYTIVKDEKVAITTQVKKWLEEDIDVIITTGG 81
Cdd:PRK03604 147 GHKRRFRPRTSAAVLVLSDSIAAGTkeDRSGKLIVEGLEEAGFEVS--HYTIIPDEPAEIAAAVAAWIAEGYALIITTGG 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970  82 TGIAQRDVTIEAVKPLLTKEIEGFGELFRylSYVEDVGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKLIkPELNH 161
Cdd:PRK03604 225 TGLGPRDVTPEALAPLLERRLPGIAEALR--SWGQGRTPTAMLSRLVAGMIGNSLVVALPGSPGGASDALAVLL-PALFH 301


                 ...
gi 446425970 162 LIH 164
Cdd:PRK03604 302 AFA 304
MoCF_biosynth pfam00994
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ...
 16-161 5.06e-33

Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerization.


Pssm-ID: 425979 [Multi-domain]  Cd Length: 143  Bit Score: 114.27  E-value: 5.06e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970   16 AVLTVSDTRNFDT--DKGGQCVRQLLQADDVEVsdAHYTIVKDEKVAITTQVKKWLEEDiDVIITTGGTGIAQRDVTIEA 93
Cdd:pfam00994   1 AIITTGDELLPGQirDTNGPLLAALLREAGAEV--IRYGIVPDDPEAIKEALRAAAEEA-DVVITTGGTGPGPDDVTPEA 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446425970   94 VKPLLTKEIEGFGELFRYLSY----VEDVGTRALLSRAvagtvnNKLIFSIPGSTGAVKLALEKLIKPELNH 161
Cdd:pfam00994  78 LAELGGRELPGFEELFRGVSLkpgkPVGTAPGAILSRA------GKTVFGLPGSPVAAKVMFELLLLPLLRH 143
MoCF_biosynth smart00852
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ...
 16-154 1.10e-32

Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.


Pssm-ID: 214856 [Multi-domain]  Cd Length: 138  Bit Score: 113.07  E-value: 1.10e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970    16 AVLTVSDTRNFDT---DKGGQCVRQLLQADDVEVSDAHYTIVKDEKVAITTQVKKWLEEdIDVIITTGGTGIAQRDVTIE 92
Cdd:smart00852   1 AIISTGDELLSGGqirDSNGPMLAALLRELGIEVVRVVVVGGPDDPEAIREALREALAE-ADVVITTGGTGPGPDDLTPE 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446425970    93 AVKPLLTKEIEGFGELFRYLSYvedVGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKL 154
Cdd:smart00852  80 ALAELGGRELLGHGVAMRPGGP---PGPLANLSGTAPGVRGKKPVFGLPGNPVAALVMFEEL 138
molyb_syn TIGR00177
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ...
 13-157 6.54e-30

molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.


Pssm-ID: 272944 [Multi-domain]  Cd Length: 148  Bit Score: 106.63  E-value: 6.54e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970   13 VKAAVLTVSDTR---------NFDTDKGGQCVRQLLQADDVEVSdaHYTIVKDEKVAITTQVKKWLEEdIDVIITTGGTG 83
Cdd:TIGR00177   1 PRVAVISVGDELveggqplepGQIYDSNGPLLAALLQEAGFNVV--RLGIVPDDPEEIREILRKAVDE-ADVVLTTGGTG 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446425970   84 IAQRDVTIEAVKPLLTKEIEGFGElFRYLSYVEdvgtraLLSR----AVAGTVNNKLIFSIPGSTGAVKLALEKLIKP 157
Cdd:TIGR00177  78 VGPRDVTPEALEELGEKEIPGFGE-FRMLSSLP------VLSRpgkpATAGVRGGTLIFNLPGNPVSALVTFEVLILP 148
 
Name Accession Description Interval E-value
MoaB COG0521
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin ...
 1-168 2.16e-70

Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin biosynthesis enzyme MoaB/MogA is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440287 [Multi-domain]  Cd Length: 169  Bit Score: 209.97  E-value: 2.16e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970   1 MGEHqnvKLNRTVKAAVLTVSDTRNF--DTDKGGQCVRQLLQADDVEVsdAHYTIVKDEKVAITTQVKKWL-EEDIDVII 77
Cdd:COG0521    1 MSSA---RAFVPLRIAVLTVSDRRSRgeREDTSGPALVELLEEAGHEV--VARRIVPDDKDAIRAALRELIdDEGVDLVL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970  78 TTGGTGIAQRDVTIEAVKPLLTKEIEGFGELFRYLSYvEDVGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKlIKP 157
Cdd:COG0521   76 TTGGTGLSPRDVTPEATRPLLDKELPGFGELFRALSL-EEIGPSAILSRAVAGIRGGTLIFNLPGSPGAVREALEA-ILP 153

                        170
                 ....*....|.
gi 446425970 158 ELNHLIHELTK 168
Cdd:COG0521  154 ELPHAVDLLNG 164
MogA_MoaB cd00886
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum ...
 13-166 2.41e-64

MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MogA, together with MoeA, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes. In contrast, MoaB shows high similarity to MogA, but little is known about its physiological role. All well studied members of this family form highly stable trimers.


Pssm-ID: 238451 [Multi-domain]  Cd Length: 152  Bit Score: 194.23  E-value: 2.41e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970  13 VKAAVLTVSDTR--NFDTDKGGQCVRQLLQADDVEVsdAHYTIVKDEKVAITTQVKKWLEE-DIDVIITTGGTGIAQRDV 89
Cdd:cd00886    1 LRAAVLTVSDTRsaGEAEDRSGPALVELLEEAGHEV--VAYEIVPDDKDEIREALIEWADEdGVDLILTTGGTGLAPRDV 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446425970  90 TIEAVKPLLTKEIEGFGELFRYLSYvEDVGTrALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKlIKPELNHLIHEL 166
Cdd:cd00886   79 TPEATRPLLDKELPGFGEAFRALSL-EETGT-AMLSRAVAGIRGGTLIFNLPGSPKAVREALEV-ILPELPHLLDLL 152
moaC PRK03604
bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional
 4-164 9.14e-36

bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional


Pssm-ID: 235138 [Multi-domain]  Cd Length: 312  Bit Score: 126.21  E-value: 9.14e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970   4 HQNVKLNRTVKAAVLTVSDTRNFDT--DKGGQCVRQLLQADDVEVSdaHYTIVKDEKVAITTQVKKWLEEDIDVIITTGG 81
Cdd:PRK03604 147 GHKRRFRPRTSAAVLVLSDSIAAGTkeDRSGKLIVEGLEEAGFEVS--HYTIIPDEPAEIAAAVAAWIAEGYALIITTGG 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970  82 TGIAQRDVTIEAVKPLLTKEIEGFGELFRylSYVEDVGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKLIkPELNH 161
Cdd:PRK03604 225 TGLGPRDVTPEALAPLLERRLPGIAEALR--SWGQGRTPTAMLSRLVAGMIGNSLVVALPGSPGGASDALAVLL-PALFH 301


                 ...
gi 446425970 162 LIH 164
Cdd:PRK03604 302 AFA 304
MoCF_biosynth pfam00994
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ...
 16-161 5.06e-33

Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerization.


Pssm-ID: 425979 [Multi-domain]  Cd Length: 143  Bit Score: 114.27  E-value: 5.06e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970   16 AVLTVSDTRNFDT--DKGGQCVRQLLQADDVEVsdAHYTIVKDEKVAITTQVKKWLEEDiDVIITTGGTGIAQRDVTIEA 93
Cdd:pfam00994   1 AIITTGDELLPGQirDTNGPLLAALLREAGAEV--IRYGIVPDDPEAIKEALRAAAEEA-DVVITTGGTGPGPDDVTPEA 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446425970   94 VKPLLTKEIEGFGELFRYLSY----VEDVGTRALLSRAvagtvnNKLIFSIPGSTGAVKLALEKLIKPELNH 161
Cdd:pfam00994  78 LAELGGRELPGFEELFRGVSLkpgkPVGTAPGAILSRA------GKTVFGLPGSPVAAKVMFELLLLPLLRH 143
MoCF_biosynth smart00852
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ...
 16-154 1.10e-32

Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.


Pssm-ID: 214856 [Multi-domain]  Cd Length: 138  Bit Score: 113.07  E-value: 1.10e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970    16 AVLTVSDTRNFDT---DKGGQCVRQLLQADDVEVSDAHYTIVKDEKVAITTQVKKWLEEdIDVIITTGGTGIAQRDVTIE 92
Cdd:smart00852   1 AIISTGDELLSGGqirDSNGPMLAALLRELGIEVVRVVVVGGPDDPEAIREALREALAE-ADVVITTGGTGPGPDDLTPE 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446425970    93 AVKPLLTKEIEGFGELFRYLSYvedVGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKL 154
Cdd:smart00852  80 ALAELGGRELLGHGVAMRPGGP---PGPLANLSGTAPGVRGKKPVFGLPGNPVAALVMFEEL 138
molyb_syn TIGR00177
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ...
 13-157 6.54e-30

molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.


Pssm-ID: 272944 [Multi-domain]  Cd Length: 148  Bit Score: 106.63  E-value: 6.54e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970   13 VKAAVLTVSDTR---------NFDTDKGGQCVRQLLQADDVEVSdaHYTIVKDEKVAITTQVKKWLEEdIDVIITTGGTG 83
Cdd:TIGR00177   1 PRVAVISVGDELveggqplepGQIYDSNGPLLAALLQEAGFNVV--RLGIVPDDPEEIREILRKAVDE-ADVVLTTGGTG 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446425970   84 IAQRDVTIEAVKPLLTKEIEGFGElFRYLSYVEdvgtraLLSR----AVAGTVNNKLIFSIPGSTGAVKLALEKLIKP 157
Cdd:TIGR00177  78 VGPRDVTPEALEELGEKEIPGFGE-FRMLSSLP------VLSRpgkpATAGVRGGTLIFNLPGNPVSALVTFEVLILP 148
MoCF_BD cd00758
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of ...
 14-159 3.42e-29

MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin.


Pssm-ID: 238387 [Multi-domain]  Cd Length: 133  Bit Score: 104.35  E-value: 3.42e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970  14 KAAVLTVSDTR--NFDTDKGGQCVRQLLQADDVEVSdaHYTIVKDEKVAITTQVKKWLEEdIDVIITTGGTGIAQRDVTI 91
Cdd:cd00758    1 RVAIVTVSDELsqGQIEDTNGPALEALLEDLGCEVI--YAGVVPDDADSIRAALIEASRE-ADLVLTTGGTGVGRRDVTP 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446425970  92 EAVKPLLTKEIEGFGelfrylsyvedvGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKLIKPEL 159
Cdd:cd00758   78 EALAELGEREAHGKG------------VALAPGSRTAFGIIGKVLIINLPGSPKSALTTFEALVLPAL 133
mogA PRK09417
molybdenum cofactor biosynthesis protein MogA; Provisional
 12-164 1.46e-21

molybdenum cofactor biosynthesis protein MogA; Provisional


Pssm-ID: 181837 [Multi-domain]  Cd Length: 193  Bit Score: 86.16  E-value: 1.46e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970  12 TVKAAVLTVSD--TRNFDTDKGGQCVRQLLQADDVEVSDAHYTIVKDEKVAI-TTQVKKWLEEDIDVIITTGGTGIAQRD 88
Cdd:PRK09417   3 TLKIGLVSISDraSSGVYEDKGIPALEEWLASALTSPFEIETRLIPDEQDLIeQTLIELVDEMGCDLVLTTGGTGPARRD 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446425970  89 VTIEAVKPLLTKEIEGFGELFRYLSyVEDVGTrALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKLIKPELNHLIH 164
Cdd:PRK09417  83 VTPEATLAVADKEMPGFGEQMRQIS-LKFVPT-AILSRQVAVIRGQSLIINLPGQPKSIKETLEGLKDADGNVVVP 156
PLN02699 PLN02699
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase
 13-166 1.36e-18

Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase


Pssm-ID: 215376 [Multi-domain]  Cd Length: 659  Bit Score: 81.78  E-value: 1.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970  13 VKAAVLTVSDT--RNFDTDKGGQCVRQLLQADDVEVSDAHY---TIVKDEKVAITTQVKKWLEED-IDVIITTGGTGIAQ 86
Cdd:PLN02699 459 VKVAILTVSDTvsSGAGPDRSGPRAVSVVNSSSEKLGGAKVvatAVVPDDVEKIKDVLQKWSDIDrMDLILTLGGTGFTP 538

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970  87 RDVTIEAVKPLLTKEIEGFgeLFRYLSYVEDVGTRALLSRAVAGTVNNKLIFSIPGSTGAVKLALEKLIkPELNHLIHEL 166
Cdd:PLN02699 539 RDVTPEATKEVIQKETPGL--LYVMMQESLKVTPFAMLSRSAAGIRGSTLIINMPGNPNAVAECMEALL-PALKHALKQI 615
MoeA cd00887
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 38-162 2.10e-07

MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.


Pssm-ID: 238452 [Multi-domain]  Cd Length: 394  Bit Score: 49.41  E-value: 2.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970  38 LLQADDVEVSDahYTIVKDEKVAITTQVKKWLEEdIDVIITTGGTGIAQRDVTIEAVKPLltkeieGFGELFRylsyved 117
Cdd:cd00887  203 LLRELGAEVVD--LGIVPDDPEALREALEEALEE-ADVVITSGGVSVGDYDFVKEVLEEL------GGEVLFH------- 266

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446425970 118 vgtrallsrAVA---------GTVNNKLIFSIPGSTGAVKLALEKLIKPELNHL 162
Cdd:cd00887  267 ---------GVAmkpgkplafGRLGGKPVFGLPGNPVSALVTFELFVRPALRKL 311
MoeA COG0303
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ...
 38-142 9.89e-06

Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440072 [Multi-domain]  Cd Length: 401  Bit Score: 44.31  E-value: 9.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446425970  38 LLQADDVEVSDahYTIVKDEKVAITTQVKKWLEEdIDVIITTGGTGIAQRDVTIEAVKPLltkeieGFGELFrylsyved 117
Cdd:COG0303  207 LLREAGAEVVD--LGIVPDDPEALRAALREALAE-ADLVITSGGVSVGDYDLVKEALEEL------GAEVLF-------- 269

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446425970 118 vgtrallsRAVA---------GTVNNKLIFSIPG 142
Cdd:COG0303  270 --------HKVAmkpgkplafGRLGGKPVFGLPG 295
MoeA_like cd03522
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in ...
 29-95 3.70e-04

MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is unknown.


Pssm-ID: 239599  Cd Length: 312  Bit Score: 39.84  E-value: 3.70e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446425970  29 DKGGQCVRQLLQADDVEVSDAhyTIVKDEKVAITTQVKKWLEEDIDVIITTGGTGIAQRDVTIEAVK 95
Cdd:cd03522  178 DKFGPVLRARLAALGVELVEQ--VIVPHDEAAIAAAIAEALEAGAELLILTGGASVDPDDVTPAAIR 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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