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Conserved domains on  [gi|446429071|ref|WP_000506926|]
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MULTISPECIES: tetratricopeptide repeat protein [Bacillus cereus group]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 569-868 8.88e-25

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 104.81  E-value: 8.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 569 YLQLATIYVAEGKNKIAIDYITKLIkdrEIDKENNEAAYLLASANFRIGKYQEAVQNFEQALANNakgiePYKKDAMRDL 648
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEAL---ELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERD-----PDRAEALLEL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 649 AVSHMKMKEFEKAEDVIVKMsTKTNEDKAIVSYLKGQLSTATVQLDKAESFFKEAIMQDSKNAIYTIELSNLYVlwnktn 728
Cdd:COG2956   83 AQDYLKAGLLDRAEELLEKL-LELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYL------ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 729 lidsakKEINYQQASHILQVAIQKDMKNIELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSSGTRDINTLV 808
Cdd:COG2956  156 ------EQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGD-------------YEEAIAALERALEQDPDYLPALP 216

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 809 NIGILYDKVGQGNEAEKLFTEAYsQNDENPHVNFAFGMFKIKQKKYEEASRFLRKTVQAN 868
Cdd:COG2956  217 RLAELYEKLGDPEEALELLRKAL-ELDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
PKc_like super family cl21453
Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the ...
 36-165 2.07e-08

Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins.


The actual alignment was detected with superfamily member cd00180:

Pssm-ID: 473864 [Multi-domain]  Cd Length: 215  Bit Score: 55.35  E-value: 2.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  36 EGRQGTVYQLQHENGMERIALKVFKERYREEKHQLAF--LKPLSSIAglkvcSRYIVtkeEHISAIEKSEDLAnsIVMPW 113
Cdd:cd00180    3 KGSFGKVYKARDKETGKKVAVKVIPKEKLKKLLEELLreIEILKKLN-----HPNIV---KLYDVFETENFLY--LVMEY 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446429071 114 VEGPTWADILQEQR-MLSKEQCFFIAEAFLTTLKMMEENEVAHNDLSSSNVLI 165
Cdd:cd00180   73 CEGGSLKDLLKENKgPLSEEEALSILRQLLSALEYLHSNGIIHRDLKPENILL 125
YfgM super family cl34530
Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal ...
 488-631 1.51e-06

Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG2976:

Pssm-ID: 442215 [Multi-domain]  Cd Length: 207  Bit Score: 49.85  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 488 HEQSEpsAFSTWWKKNKKRILIIgstVVVVIGGSTLFYFYTTNAKYQkfMEQARQAYD-------NKKYTKAEEAVGhAI 560
Cdd:COG2976    8 EEQLE--AIKKWWKENGKAIIVG---VVLGLAAVFGWRYWQSYQESQ--AEEASALYEqllealaAGDAAAAAAAAE-KL 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446429071 561 AVKGKDEAY-----LQLATIYVAEGKNKIAIDYITKLIkdreidkENNEAAYLLASANFRIGKYQEAVQNFEQALA 631
Cdd:COG2976   80 IDDYGGTAYaalaaLLLAKAAVDAGDLDKAAAQLQWVL-------DNAKDPALKALARLRLARVLLAQKKYDEALA 148
PKc_like super family cl21453
Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the ...
 107-286 1.52e-03

Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins.


The actual alignment was detected with superfamily member cd05037:

Pssm-ID: 473864 [Multi-domain]  Cd Length: 259  Bit Score: 41.31  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 107 NSIVMPWVE-GP--TWadiLQEQRMLSKEQCFF-IAEAFLTTLKMMEENEVAHNDLSSSNVLIpfLSENPIEGQHYIELV 182
Cdd:cd05037   76 NIMVQEYVRyGPldKY---LRRMGNNVPLSWKLqVAKQLASALHYLEDKKLIHGNVRGRNILL--AREGLDGYPPFIKLS 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 183 D--VEQMYGPKTKRPSLLPagsaGYAPMYLKSGV--WQKEADRFAGAILLGEILSWCSEEvrnkkwtdasyFKTEEMQKE 258
Cdd:cd05037  151 DpgVPITVLSREERVDRIP----WIAPECLRNLQanLTIAADKWSFGTTLWEICSGGEEP-----------LSALSSQEK 215

                        170       180
                 ....*....|....*....|....*...
gi 446429071 259 CERYTLLQQVLHNQWnGEIAKLFKQAWS 286
Cdd:cd05037  216 LQFYEDQHQLPAPDC-AELAELIMQCWT 242
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 569-868 8.88e-25

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 104.81  E-value: 8.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 569 YLQLATIYVAEGKNKIAIDYITKLIkdrEIDKENNEAAYLLASANFRIGKYQEAVQNFEQALANNakgiePYKKDAMRDL 648
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEAL---ELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERD-----PDRAEALLEL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 649 AVSHMKMKEFEKAEDVIVKMsTKTNEDKAIVSYLKGQLSTATVQLDKAESFFKEAIMQDSKNAIYTIELSNLYVlwnktn 728
Cdd:COG2956   83 AQDYLKAGLLDRAEELLEKL-LELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYL------ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 729 lidsakKEINYQQASHILQVAIQKDMKNIELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSSGTRDINTLV 808
Cdd:COG2956  156 ------EQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGD-------------YEEAIAALERALEQDPDYLPALP 216

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 809 NIGILYDKVGQGNEAEKLFTEAYsQNDENPHVNFAFGMFKIKQKKYEEASRFLRKTVQAN 868
Cdd:COG2956  217 RLAELYEKLGDPEEALELLRKAL-ELDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 567-870 8.45e-15

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 78.97  E-value: 8.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  567 EAYLQLATIYVAEGKNKIAIDYITKLIKdreIDKENNEAAYLLASANFRIGKYQEAVQNFEQALANNAKgiepyKKDAMR 646
Cdd:TIGR02917  23 EELIEAAKSYLQKNKYKAAIIQLKNALQ---KDPNDAEARFLLGKIYLALGDYAAAEKELRKALSLGYP-----KNQVLP 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  647 DLAVSHMKMKEFEKAEDVIVKMSTKTNEDKAIVSYLKGQLSTATVQLDKAESFFKEAImqdsknaiyTIELSNLYVlwnK 726
Cdd:TIGR02917  95 LLARAYLLQGKFQQVLDELPGKTLLDDEGAAELLALRGLAYLGLGQLELAQKSYEQAL---------AIDPRSLYA---K 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  727 TNLIDSAKKEINYQQASHILQVAIQKDMKNIELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSSGTRDINT 806
Cdd:TIGR02917 163 LGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGN-------------IELALAAYRKAIALRPNNIAV 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446429071  807 LVNIGILYDKVGQGNEAEKLFTEAYSQNDENPHVNFAFGMFKIKQKKYEEASRFLRKTVQANEN 870
Cdd:TIGR02917 230 LLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPE 293
PKc cd00180
Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group ...
 36-165 2.07e-08

Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. PKs make up a large family of serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and more than 500 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase.


Pssm-ID: 270622 [Multi-domain]  Cd Length: 215  Bit Score: 55.35  E-value: 2.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  36 EGRQGTVYQLQHENGMERIALKVFKERYREEKHQLAF--LKPLSSIAglkvcSRYIVtkeEHISAIEKSEDLAnsIVMPW 113
Cdd:cd00180    3 KGSFGKVYKARDKETGKKVAVKVIPKEKLKKLLEELLreIEILKKLN-----HPNIV---KLYDVFETENFLY--LVMEY 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446429071 114 VEGPTWADILQEQR-MLSKEQCFFIAEAFLTTLKMMEENEVAHNDLSSSNVLI 165
Cdd:cd00180   73 CEGGSLKDLLKENKgPLSEEEALSILRQLLSALEYLHSNGIIHRDLKPENILL 125
YfgM COG2976
Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal ...
 488-631 1.51e-06

Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal transduction mechanisms];


Pssm-ID: 442215 [Multi-domain]  Cd Length: 207  Bit Score: 49.85  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 488 HEQSEpsAFSTWWKKNKKRILIIgstVVVVIGGSTLFYFYTTNAKYQkfMEQARQAYD-------NKKYTKAEEAVGhAI 560
Cdd:COG2976    8 EEQLE--AIKKWWKENGKAIIVG---VVLGLAAVFGWRYWQSYQESQ--AEEASALYEqllealaAGDAAAAAAAAE-KL 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446429071 561 AVKGKDEAY-----LQLATIYVAEGKNKIAIDYITKLIkdreidkENNEAAYLLASANFRIGKYQEAVQNFEQALA 631
Cdd:COG2976   80 IDDYGGTAYaalaaLLLAKAAVDAGDLDKAAAQLQWVL-------DNAKDPALKALARLRLARVLLAQKKYDEALA 148
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
36-165 6.90e-06

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 49.63  E-value: 6.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  36 EGRQGTVYQLQHENGMERIALKVFKERYREEKHQLA-FLKPLSSIAGLKvcSRYIVTkeehISAIEKSEDLAnSIVMPWV 114
Cdd:COG0515   17 RGGMGVVYLARDLRLGRPVALKVLRPELAADPEARErFRREARALARLN--HPNIVR----VYDVGEEDGRP-YLVMEYV 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446429071 115 EGPTWADILQEQRMLSKEQCFFIAEAFLTTLKMMEENEVAHNDLSSSNVLI 165
Cdd:COG0515   90 EGESLADLLRRRGPLPPAEALRILAQLAEALAAAHAAGIVHRDIKPANILL 140
TPR_19 pfam14559
Tetratricopeptide repeat;
818-881 1.44e-05

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 43.34  E-value: 1.44e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446429071  818 GQGNEAEKLFTEAYSQNDENPHVNFAFGMFKIKQKKYEEASRFLRKTVQANENESEVRAAQEKL 881
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALLAKL 65
PTK_Jak_rpt1 cd05037
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak ...
 107-286 1.52e-03

Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily is composed of Jak1, Jak2, Jak3, TYK2, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. It modulates the kinase activity of the C-terminal catalytic domain. In the case of Jak2, the presumed pseudokinase (repeat 1) domain exhibits dual-specificity kinase activity, phosphorylating two negative regulatory sites in Jak2: Ser523 and Tyr570. Most Jaks are expressed in a wide variety of tissues, except for Jak3, which is expressed only in hematopoietic cells. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). Jaks are also involved in regulating the surface expression of some cytokine receptors. The Jak-STAT pathway is involved in many biological processes including hematopoiesis, immunoregulation, host defense, fertility, lactation, growth, and embryogenesis. The Jak subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270633 [Multi-domain]  Cd Length: 259  Bit Score: 41.31  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 107 NSIVMPWVE-GP--TWadiLQEQRMLSKEQCFF-IAEAFLTTLKMMEENEVAHNDLSSSNVLIpfLSENPIEGQHYIELV 182
Cdd:cd05037   76 NIMVQEYVRyGPldKY---LRRMGNNVPLSWKLqVAKQLASALHYLEDKKLIHGNVRGRNILL--AREGLDGYPPFIKLS 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 183 D--VEQMYGPKTKRPSLLPagsaGYAPMYLKSGV--WQKEADRFAGAILLGEILSWCSEEvrnkkwtdasyFKTEEMQKE 258
Cdd:cd05037  151 DpgVPITVLSREERVDRIP----WIAPECLRNLQanLTIAADKWSFGTTLWEICSGGEEP-----------LSALSSQEK 215

                        170       180
                 ....*....|....*....|....*...
gi 446429071 259 CERYTLLQQVLHNQWnGEIAKLFKQAWS 286
Cdd:cd05037  216 LQFYEDQHQLPAPDC-AELAELIMQCWT 242
TPR_21 pfam09976
Tetratricopeptide repeat-like domain; This family resembles a single unit of a TPR repeat.
 499-631 2.37e-03

Tetratricopeptide repeat-like domain; This family resembles a single unit of a TPR repeat.


Pssm-ID: 430959 [Multi-domain]  Cd Length: 194  Bit Score: 40.26  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  499 WWKKNKKRILIIgstVVVVIGGSTLFYFYTTNAKYQKfmEQARQAYDN-------KKYTKAEEAVGhAIAVKGKDEAY-- 569
Cdd:pfam09976   3 WWKENGKLIIIG---VVIGLGGLFGWNGWQYYQRSQA--EEASALYQQlleavaaGDAAKAQAAAA-QLKDEYGGTGYaa 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446429071  570 ---LQLATIYVAEGKNKIAIDYITKLIkdreidkENNEAAYLLASANFRIGKYQEAVQNFEQALA 631
Cdd:pfam09976  77 laaLLLAKAAVEAGDLAAAKAQLEWVA-------DNAKDEALKALARLRLARVLLAQGKYDEALK 134
Pkinase pfam00069
Protein kinase domain;
36-184 3.01e-03

Protein kinase domain;


Pssm-ID: 459660 [Multi-domain]  Cd Length: 217  Bit Score: 39.92  E-value: 3.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071   36 EGRQGTVYQLQHENGMERIALK-VFKERYREEKHQLAflkpLSSIAGLKVCS-RYIVTkeeHISAIEKSEDLanSIVMPW 113
Cdd:pfam00069   9 SGSFGTVYKAKHRDTGKIVAIKkIKKEKIKKKKDKNI----LREIKILKKLNhPNIVR---LYDAFEDKDNL--YLVLEY 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446429071  114 VEGPTWADILQEQRMLSKEQCFFIaeaFLTTLKMMEENEVAHNDLSSSNVLIPFLsenpIEGQHYIELVDV 184
Cdd:pfam00069  80 VEGGSLFDLLSEKGAFSEREAKFI---MKQILEGLESGSSLTTFVGTPWYMAPEV----LGGNPYGPKVDV 143
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 569-868 8.88e-25

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 104.81  E-value: 8.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 569 YLQLATIYVAEGKNKIAIDYITKLIkdrEIDKENNEAAYLLASANFRIGKYQEAVQNFEQALANNakgiePYKKDAMRDL 648
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEAL---ELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERD-----PDRAEALLEL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 649 AVSHMKMKEFEKAEDVIVKMsTKTNEDKAIVSYLKGQLSTATVQLDKAESFFKEAIMQDSKNAIYTIELSNLYVlwnktn 728
Cdd:COG2956   83 AQDYLKAGLLDRAEELLEKL-LELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYL------ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 729 lidsakKEINYQQASHILQVAIQKDMKNIELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSSGTRDINTLV 808
Cdd:COG2956  156 ------EQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGD-------------YEEAIAALERALEQDPDYLPALP 216

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 809 NIGILYDKVGQGNEAEKLFTEAYsQNDENPHVNFAFGMFKIKQKKYEEASRFLRKTVQAN 868
Cdd:COG2956  217 RLAELYEKLGDPEEALELLRKAL-ELDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 538-834 5.93e-23

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 99.80  E-value: 5.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 538 EQARQAYDNKKYTKAEEAVGHAIAVKGKD-EAYLQLATIYVAEGKNKIAIDYITKLIkdrEIDKENNEAAYLLASANFRI 616
Cdd:COG2956   13 FKGLNYLLNGQPDKAIDLLEEALELDPETvEAHLALGNLYRRRGEYDRAIRIHQKLL---ERDPDRAEALLELAQDYLKA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 617 GKYQEAVQNFEQALAnnakgIEPYKKDAMRDLAVSHMKMKEFEKAEDVIVKMStKTNEDKAIVSYLKGQLSTATVQLDKA 696
Cdd:COG2956   90 GLLDRAEELLEKLLE-----LDPDDAEALRLLAEIYEQEGDWEKAIEVLERLL-KLGPENAHAYCELAELYLEQGDYDEA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 697 ESFFKEAIMQDSKNAIYTIELSNLYVLWNktnlidsakkeiNYQQASHILQVAIQKDMKNIELLNQLGIVYYEAGQfyet 776
Cdd:COG2956  164 IEALEKALKLDPDCARALLLLAELYLEQG------------DYEEAIAALERALEQDPDYLPALPRLAELYEKLGD---- 227

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446429071 777 rdgakstaaYQQALEAYNRVVSSgTRDINTLVNIGILYDKVGQGNEAEKLFTEAYSQN 834
Cdd:COG2956  228 ---------PEEALELLRKALEL-DPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 677-881 3.59e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 76.69  E-value: 3.59e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 677 AIVSYLKGQLSTATVQLDKAESFFKEAIMQDSKNAIYTIELSNLYvlwnktnlidSAKKEinYQQASHILQVAIQKDMKN 756
Cdd:COG2956    8 ALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLY----------RRRGE--YDRAIRIHQKLLERDPDR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 757 IELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSSGTRDINTLVNIGILYDKVGQGNEAEKLFTEAYSQNDE 836
Cdd:COG2956   76 AEALLELAQDYLKAGL-------------LDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE 142

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446429071 837 NPHVNFAFGMFKIKQKKYEEASRFLRKTVQANENESEVRAAQEKL 881
Cdd:COG2956  143 NAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAEL 187
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 567-870 8.45e-15

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 78.97  E-value: 8.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  567 EAYLQLATIYVAEGKNKIAIDYITKLIKdreIDKENNEAAYLLASANFRIGKYQEAVQNFEQALANNAKgiepyKKDAMR 646
Cdd:TIGR02917  23 EELIEAAKSYLQKNKYKAAIIQLKNALQ---KDPNDAEARFLLGKIYLALGDYAAAEKELRKALSLGYP-----KNQVLP 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  647 DLAVSHMKMKEFEKAEDVIVKMSTKTNEDKAIVSYLKGQLSTATVQLDKAESFFKEAImqdsknaiyTIELSNLYVlwnK 726
Cdd:TIGR02917  95 LLARAYLLQGKFQQVLDELPGKTLLDDEGAAELLALRGLAYLGLGQLELAQKSYEQAL---------AIDPRSLYA---K 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  727 TNLIDSAKKEINYQQASHILQVAIQKDMKNIELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSSGTRDINT 806
Cdd:TIGR02917 163 LGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGN-------------IELALAAYRKAIALRPNNIAV 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446429071  807 LVNIGILYDKVGQGNEAEKLFTEAYSQNDENPHVNFAFGMFKIKQKKYEEASRFLRKTVQANEN 870
Cdd:TIGR02917 230 LLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPE 293
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 648-876 4.13e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 73.61  E-value: 4.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 648 LAVSHMKMKEFEKAEDVIVKMSTKTNEDKAIVSYLkGQLSTATVQLDKAESFFKEAIMQDSKNAIYTIELSNLYVlwnkt 727
Cdd:COG2956   14 KGLNYLLNGQPDKAIDLLEEALELDPETVEAHLAL-GNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYL----- 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 728 nlidsakKEINYQQASHILQVAIQKDMKNIELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSSGTRDINTL 807
Cdd:COG2956   88 -------KAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGD-------------WEKAIEVLERLLKLGPENAHAY 147

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446429071 808 VNIGILYDKVGQGNEAEKLFTEAYSQNDENPHVNFAFGMFKIKQKKYEEASRFLRKTVQANENESEVRA 876
Cdd:COG2956  148 CELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALP 216
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
738-874 2.05e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.81  E-value: 2.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 738 NYQQASHILQVAIQKDMKNIELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSSGTRDINTLVNIGILYDKV 817
Cdd:COG0457   23 RYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGR-------------YEEALADYEQALELDPDDAEALNNLGLALQAL 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446429071 818 GQGNEAEKLFTEAYSQNDENPHVNFAFGMFKIKQKKYEEASRFLRKTVQANENESEV 874
Cdd:COG0457   90 GRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADA 146
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 537-721 4.72e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 70.53  E-value: 4.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 537 MEQARQAYDNKKYTKAEEAVGHAIAVKGKD-EAYLQLATIYVAEGKNKIAIDYITKLIKdreIDKENNEAAYLLASANFR 615
Cdd:COG2956   80 LELAQDYLKAGLLDRAEELLEKLLELDPDDaEALRLLAEIYEQEGDWEKAIEVLERLLK---LGPENAHAYCELAELYLE 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 616 IGKYQEAVQNFEQALAnnakgIEPYKKDAMRDLAVSHMKMKEFEKAEDVIVKMsTKTNEDKAIVSYLKGQLSTATVQLDK 695
Cdd:COG2956  157 QGDYDEAIEALEKALK-----LDPDCARALLLLAELYLEQGDYEEAIAALERA-LEQDPDYLPALPRLAELYEKLGDPEE 230

                        170       180
                 ....*....|....*....|....*.
gi 446429071 696 AESFFKEAIMQDSKNAIYtIELSNLY 721
Cdd:COG2956  231 ALELLRKALELDPSDDLL-LALADLL 255
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
567-795 4.73e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.04  E-value: 4.73e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 567 EAYLQLATIYVAEGKNKIAIDYITKLIkdrEIDKENNEAAYLLASANFRIGKYQEAVQNFEQALAnnakgIEPYKKDAMR 646
Cdd:COG0457    9 EAYNNLGLAYRRLGRYEEAIEDYEKAL---ELDPDDAEALYNLGLAYLRLGRYEEALADYEQALE-----LDPDDAEALN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 647 DLAVSHMKMKEFEKAEDVIVKmSTKTNEDKAIVSYLKGQLSTATVQLDKAESFFKEAIMQDSKNAIYTIELSNLYVLWNK 726
Cdd:COG0457   81 NLGLALQALGRYEEALEDYDK-ALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGR 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 727 TNL-IDSAKKEINYQQASHILQVAIQKDMKNIELLNQLGIVYYEAGQFYETRDGAKSTAAYQQALEAYNR 795
Cdd:COG0457  160 YEEaLELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALAL 229
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
597-881 8.61e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 69.27  E-value: 8.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 597 EIDKENNEAAYLLASANFRIGKYQEAVQNFEQALAnnakgIEPYKKDAMRDLAVSHMKMKEFEKAEDvivkmstktnedk 676
Cdd:COG0457    2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALE-----LDPDDAEALYNLGLAYLRLGRYEEALA------------- 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 677 aivsylkgqlstatvqldkaesFFKEAIMQDSKNAIYTIELSNLYVLWNktnlidsakkeiNYQQASHILQVAIQKDMKN 756
Cdd:COG0457   64 ----------------------DYEQALELDPDDAEALNNLGLALQALG------------RYEEALEDYDKALELDPDD 109

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 757 IELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSSGTRDINTLVNIGILYDKVGQGNEAEKLFTEAYSQNDE 836
Cdd:COG0457  110 AEALYNLGLALLELGR-------------YDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALA 176

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 446429071 837 NPHVNFAFGMFKIKQKKYEEASRFLRKTVQANENESEVRAAQEKL 881
Cdd:COG0457  177 ALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAE 221
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 534-638 9.32e-12

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 63.10  E-value: 9.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 534 QKFMEQARQAYDNKKYTKAEEAVGHAIAVKGKD-EAYLQLATIYVAEGKNKIAIDYITKLIkdrEIDKENNEAAYLLASA 612
Cdd:COG4235   18 EGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNaDALLDLAEALLAAGDTEEAEELLERAL---ALDPDNPEALYLLGLA 94

                         90       100
                 ....*....|....*....|....*.
gi 446429071 613 NFRIGKYQEAVQNFEQALANNAKGIE 638
Cdd:COG4235   95 AFQQGDYAEAIAAWQKLLALLPADAP 120
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 546-881 1.06e-11

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 68.96  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  546 NKKYTKAEEAVGHAIAVKGKDEAYLQLA-TIYVAEGKNKIAIDYitkLIKDREIDKENNEAAYLLASANFRIGKYQEAVQ 624
Cdd:TIGR02917 342 LGRVDEAIATLSPALGLDPDDPAALSLLgEAYLALGDFEKAAEY---LAKATELDPENAAARTQLGISKLSQGDPSEAIA 418

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  625 NFEQALAnnakgIEPYKKDAMRDLAVSHMKMKEFEKAEDVIVKMSTKTnEDKAIVSYLKGQLSTATVQLDKAESFFKEAI 704
Cdd:TIGR02917 419 DLETAAQ-----LDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQ-PDNASLHNLLGAIYLGKGDLAKAREAFEKAL 492

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  705 MQDSKNAIYTIELSNLYVlwnKTNLIDSAKKEinyqqashiLQVAIQKDMKNIELLNQLGIVYY------EAGQFYET-- 776
Cdd:TIGR02917 493 SIEPDFFPAAANLARIDI---QEGNPDDAIQR---------FEKVLTIDPKNLRAILALAGLYLrtgneeEAVAWLEKaa 560

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  777 ------RDGAKSTAAY-------QQALEAYNRVVSSGTRDINTLVNIGILYDKVGQGNEAEKLFTEAYSQNDEN--PHVN 841
Cdd:TIGR02917 561 elnpqeIEPALALAQYylgkgqlKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSalALLL 640

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 446429071  842 FAFgmFKIKQKKYEEASRFLRKTVQANENESEVRAAQEKL 881
Cdd:TIGR02917 641 LAD--AYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQL 678
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 746-883 2.21e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 61.95  E-value: 2.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 746 LQVAIQKDMKNIELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSSGTRDINTLVNIGILYDKVGQGNEAEK 825
Cdd:COG4235    6 LRQALAANPNDAEGWLLLGRAYLRLGR-------------YDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEE 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446429071 826 LFTEAYSQNDENPHVNFAFGMFKIKQKKYEEASRFLRKTVQANENESEVRAAQEKLTE 883
Cdd:COG4235   73 LLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASIAE 130
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 546-870 2.30e-11

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 67.80  E-value: 2.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  546 NKKYTKAEEAVGHAIAVKGKD-EAYLQLATIYVAEGKNKIAIDYITKLIKdreIDKENNEAAYLLASANFRIGKYQEAVQ 624
Cdd:TIGR02917 478 KGDLAKAREAFEKALSIEPDFfPAAANLARIDIQEGNPDDAIQRFEKVLT---IDPKNLRAILALAGLYLRTGNEEEAVA 554

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  625 NFEQALANNAKGIEPYKKdamrdLAVSHMKMKEFEKAEDVIVKMSTKTNEDKAIVSyLKGQLSTATVQLDKAESFFKEAI 704
Cdd:TIGR02917 555 WLEKAAELNPQEIEPALA-----LAQYYLGKGQLKKALAILNEAADAAPDSPEAWL-MLGRAQLAAGDLNKAVSSFKKLL 628

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  705 -------------------MQDSKNAIYTIELS------------NLYVLWNKTNLIDSAKKEINYQQASHILQVAIQKd 753
Cdd:TIGR02917 629 alqpdsalalllladayavMKNYAKAITSLKRAlelkpdnteaqiGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFE- 707

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  754 mkniellnQLGIVYYEAGQFyetrdgaksTAAYQQALEAYNRVVSSGTrdintLVNIGILYDKVGQGNEAEKLFTEAYSQ 833
Cdd:TIGR02917 708 --------LEGDLYLRQKDY---------PAAIQAYRKALKRAPSSQN-----AIKLHRALLASGNTAEAVKTLEAWLKT 765

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 446429071  834 NDENPHVNFAFGMFKIKQKKYEEASRFLRKTVQANEN 870
Cdd:TIGR02917 766 HPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPD 802
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 738-877 4.28e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.56  E-value: 4.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 738 NYQQASHILQVAIQKDMKNIELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSSGTRDINTLVNIGILYDKV 817
Cdd:COG3914   93 RYEEALALYRRALALNPDNAEALFNLGNLLLALGR-------------LEEALAALRRALALNPDFAEAYLNLGEALRRL 159

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 818 GQGNEAEKLFTEAYSQNDENPHVNFAFGMFKIKQKKYEEASRFLRKTVQANENESEVRAA 877
Cdd:COG3914  160 GRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSN 219
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 531-675 5.15e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 61.36  E-value: 5.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 531 AKYQKFMEQARQAYDNKKYTKAEEAVGHAIAVKGKD-EAYLQLATIYVAEGKNKIAIDYITKLIkdrEIDKENNEAAYLL 609
Cdd:COG4783    2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNpEAFALLGEILLQLGDLDEAIVLLHEAL---ELDPDEPEARLNL 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446429071 610 ASANFRIGKYQEAVQNFEQALAnnakgIEPYKKDAMRDLAVSHMKMKEFEKAEDVIVKMSTKTNED 675
Cdd:COG4783   79 GLALLKAGDYDEALALLEKALK-----LDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 738-871 1.15e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 60.21  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 738 NYQQASHILQVAIQKDMKNIELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSSGTRDINTLVNIGILYDKV 817
Cdd:COG4783   19 DYDEAEALLEKALELDPDNPEAFALLGEILLQLGD-------------LDEAIVLLHEALELDPDEPEARLNLGLALLKA 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446429071 818 GQGNEAEKLFTEAYSQNDENPHVNFAFGMFKIKQKKYEEASRFLRKTVQANENE 871
Cdd:COG4783   86 GDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 534-875 5.44e-10

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 63.18  E-value: 5.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  534 QKFMEQARQAYDNKKYTKAEEAVGHAIAVKGKD-EAYLQLATIYVAEG------------------KNKIAIDYITKLIK 594
Cdd:TIGR02917  23 EELIEAAKSYLQKNKYKAAIIQLKNALQKDPNDaEARFLLGKIYLALGdyaaaekelrkalslgypKNQVLPLLARAYLL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  595 DREIDK-----------ENNEAAYLLA---SANFRIGKYQEAVQNFEQALAnnakgIEPYKKDAMRDLAVSHMKMKEFEK 660
Cdd:TIGR02917 103 QGKFQQvldelpgktllDDEGAAELLAlrgLAYLGLGQLELAQKSYEQALA-----IDPRSLYAKLGLAQLALAENRFDE 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  661 AEDVIVKMSTKTNEDKAIVSyLKGQLSTATVQLDKAESFFKEAIMQDSKNAIYTIELSNLYVLWNK--------TNLIDS 732
Cdd:TIGR02917 178 ARALIDEVLTADPGNVDALL-LKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEfeeaekhaDALLKK 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  733 AKKEI--------------NYQQASHILQVAIQKDMKNIELLNQLGIVYYEAGQFYETR-------------DGAKSTAA 785
Cdd:TIGR02917 257 APNSPlahylkalvdfqkkNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYqylnqilkyapnsHQARRLLA 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  786 --------YQQALEAYNRVVSSGTRDINTLVNIGILYDKVGQGNEAEKLFTEAYSQNDENPHVNFAFGMFKIKQKKYEEA 857
Cdd:TIGR02917 337 siqlrlgrVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEA 416

                         410
                  ....*....|....*...
gi 446429071  858 SRFLRKTVQANENESEVR 875
Cdd:TIGR02917 417 IADLETAAQLDPELGRAD 434
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 676-837 9.78e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.51  E-value: 9.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 676 KAIVSYLKGQLSTATVQLDKAESFFKEAIMQDSKNAIYTIELSNLYVLWNKtnlidsakkeinYQQASHILQVAIQKDMK 755
Cdd:COG4783    3 CAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGD------------LDEAIVLLHEALELDPD 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 756 NIELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSSGTRDINTLVNIGILYDKVGQGNEAEKLFTEAYSQND 835
Cdd:COG4783   71 EPEARLNLGLALLKAGD-------------YDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137


                 ..
gi 446429071 836 EN 837
Cdd:COG4783  138 DD 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
750-875 8.98e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 57.32  E-value: 8.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 750 IQKDMKNIELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSSGTRDINTLVNIGILYDKVGQGNEAEKLFTE 829
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGR-------------YEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQ 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 446429071 830 AYSQNDENPHVNFAFGMFKIKQKKYEEASRFLRKTVQANENESEVR 875
Cdd:COG0457   68 ALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEAL 113
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 537-668 1.41e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.05  E-value: 1.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 537 MEQARQAYDNKKYTKAEEAVGHAIAVKGKD-EAYLQLATIYVAEGKNKIAIDYITKLIkdrEIDKENNEAAYLLASANFR 615
Cdd:COG2956  148 CELAELYLEQGDYDEAIEALEKALKLDPDCaRALLLLAELYLEQGDYEEAIAALERAL---EQDPDYLPALPRLAELYEK 224

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446429071 616 IGKYQEAVQNFEQALANNAkgiepyKKDAMRDLAVSHMKMKEFEKAEDVIVKM 668
Cdd:COG2956  225 LGDPEEALELLRKALELDP------SDDLLLALADLLERKEGLEAALALLERQ 271
PKc cd00180
Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group ...
 36-165 2.07e-08

Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. PKs make up a large family of serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and more than 500 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase.


Pssm-ID: 270622 [Multi-domain]  Cd Length: 215  Bit Score: 55.35  E-value: 2.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  36 EGRQGTVYQLQHENGMERIALKVFKERYREEKHQLAF--LKPLSSIAglkvcSRYIVtkeEHISAIEKSEDLAnsIVMPW 113
Cdd:cd00180    3 KGSFGKVYKARDKETGKKVAVKVIPKEKLKKLLEELLreIEILKKLN-----HPNIV---KLYDVFETENFLY--LVMEY 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446429071 114 VEGPTWADILQEQR-MLSKEQCFFIAEAFLTTLKMMEENEVAHNDLSSSNVLI 165
Cdd:cd00180   73 CEGGSLKDLLKENKgPLSEEEALSILRQLLSALEYLHSNGIIHRDLKPENILL 125
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 758-875 3.81e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.89  E-value: 3.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 758 ELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSSGTRDINTLVNIGILYDKVGQGNEAEKLFTEAYSQNDEN 837
Cdd:COG4783    5 EALYALAQALLLAGD-------------YDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDE 71

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446429071 838 PHVNFAFGMFKIKQKKYEEASRFLRKTVQANENESEVR 875
Cdd:COG4783   72 PEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAY 109
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 604-874 5.02e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.93  E-value: 5.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 604 EAAYLLASANFRIGKYQEAVQNFEQALANNAKGIEPYKKDAMRDLAVSHmkmkEFEKAEDVIVKMSTKTNEDKAIVSYLK 683
Cdd:COG3914    2 AAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAA----LAEAAAAALLALAAGEAAAAAAALLLL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 684 GQLST-------ATVQLDKAESFFKEAIMQDSKNAIYTIELSNLYVLWNKtnlidsakkeinYQQASHILQVAIQKDMKN 756
Cdd:COG3914   78 AALLElaalllqALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGR------------LEEALAALRRALALNPDF 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 757 IELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSSGTRDINTLVNIGILYDKVGQGNEAEKLFTEAYSQNDE 836
Cdd:COG3914  146 AEAYLNLGEALRRLGR-------------LEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPD 212

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 446429071 837 NPHVNFAFGMFKIKQKKYEEASRFLRKTVQANENESEV 874
Cdd:COG3914  213 NADAHSNLLFALRQACDWEVYDRFEELLAALARGPSEL 250
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 539-665 8.83e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 52.66  E-value: 8.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 539 QARQAYDNKKYTKAEEAVGHAIAVKGKDEAYLQLATIYVAEGKNKIAIDYITKLIkdrEIDKENNEAAYLLASANFRIGK 618
Cdd:COG5010   27 YEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQAL---QLDPNNPELYYNLALLYSRSGD 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 446429071 619 YQEAVQNFEQALAnnakgIEPYKKDAMRDLAVSHMKMKEFEKAEDVI 665
Cdd:COG5010  104 KDEAKEYYEKALA-----LSPDNPNAYSNLAALLLSLGQDDEAKAAL 145
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 720-868 9.91e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 52.27  E-value: 9.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 720 LYVLWNKTNLIDSAKKEINYQQASHILQVAIQKDMKNIELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSS 799
Cdd:COG5010   17 LTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGD-------------FEESLALLEQALQL 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446429071 800 GTRDINTLVNIGILYDKVGQGNEAEKLFTEAYSQNDENPHVNFAFGMFKIKQKKYEEASRFLRKTVQAN 868
Cdd:COG5010   84 DPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 576-661 1.80e-07

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 50.38  E-value: 1.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 576 YVAEGKNKIAIDYITKLIKDREIDKENNEAAYLLASANFRIGKYQEAVQNFEQALANNAKGiePYKKDAMRDLAVSHMKM 655
Cdd:COG1729    3 LLKAGDYDEAIAAFKAFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDS--PKAPDALLKLGLSYLEL 80


                 ....*.
gi 446429071 656 KEFEKA 661
Cdd:COG1729   81 GDYDKA 86
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
543-635 7.19e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 48.24  E-value: 7.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 543 AYDNKKYTKAEEAVGHAIAVKGKD-EAYLQLATIYVAEGKNKIAIDYITKLikdrEIDKENNEAAYLLASANFRIGKYQE 621
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNaDALNNLGLLLLEQGRYDEAIALEKAL----KLDPNNAEALLNLAELLLELGDYDE 77

                         90
                 ....*....|....
gi 446429071 622 AVQNFEQALANNAK 635
Cdd:COG3063   78 ALAYLERALELDPS 91
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 566-713 1.27e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 52.30  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 566 DEAYLQLATIYVAEGKNKIAIDYITKLIkdrEIDKENNEAAYLLASANFRIGKYQEAVQNFEQALANNAKGIEpykkdAM 645
Cdd:COG3914   78 AALLELAALLLQALGRYEEALALYRRAL---ALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAE-----AY 149

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446429071 646 RDLAVSHMKMKEFEKAEDvIVKMSTKTNEDKAIVSYLKGQLSTATVQLDKAESFFKEAIMQDSKNAIY 713
Cdd:COG3914  150 LNLGEALRRLGRLEEAIA-ALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADA 216
YfgM COG2976
Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal ...
 488-631 1.51e-06

Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal transduction mechanisms];


Pssm-ID: 442215 [Multi-domain]  Cd Length: 207  Bit Score: 49.85  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 488 HEQSEpsAFSTWWKKNKKRILIIgstVVVVIGGSTLFYFYTTNAKYQkfMEQARQAYD-------NKKYTKAEEAVGhAI 560
Cdd:COG2976    8 EEQLE--AIKKWWKENGKAIIVG---VVLGLAAVFGWRYWQSYQESQ--AEEASALYEqllealaAGDAAAAAAAAE-KL 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446429071 561 AVKGKDEAY-----LQLATIYVAEGKNKIAIDYITKLIkdreidkENNEAAYLLASANFRIGKYQEAVQNFEQALA 631
Cdd:COG2976   80 IDDYGGTAYaalaaLLLAKAAVDAGDLDKAAAQLQWVL-------DNAKDPALKALARLRLARVLLAQKKYDEALA 148
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 533-791 2.03e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.53  E-value: 2.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 533 YQKFMEQARQAYDNKKYTKAEEAVGHAIAVKGKDEAYLQLATIYVAEGKNKIAIDYITKLIKDREIDKENNEAAYLLASA 612
Cdd:COG3914    1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 613 NF-------RIGKYQEAVQNFEQALAnnakgIEPYKKDAMRDLAVSHMKMKEFEKAEDVivkmstktnedkaivsylkgq 685
Cdd:COG3914   81 LElaalllqALGRYEEALALYRRALA-----LNPDNAEALFNLGNLLLALGRLEEALAA--------------------- 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 686 lstatvqldkaesfFKEAIMQDSKNAIYTIELSNLYVlwnKTNlidsakkeiNYQQASHILQVAIQKDMKNIELLNQLGI 765
Cdd:COG3914  135 --------------LRRALALNPDFAEAYLNLGEALR---RLG---------RLEEAIAALRRALELDPDNAEALNNLGN 188

                        250       260
                 ....*....|....*....|....*.
gi 446429071 766 VYYEAGQFyetrdgAKSTAAYQQALE 791
Cdd:COG3914  189 ALQDLGRL------EEAIAAYRRALE 208
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 531-633 3.56e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 47.65  E-value: 3.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 531 AKYQKFMEQARQAYD-NKKYTKAEEAVGHAIAVKGKD-EAYLQLATIYVAEGKNKIAIDYITKLIkdrEIDKENNEAAYL 608
Cdd:COG5010   51 AKAFAIESPSDNLYNkLGDFEESLALLEQALQLDPNNpELYYNLALLYSRSGDKDEAKEYYEKAL---ALSPDNPNAYSN 127

                         90       100
                 ....*....|....*....|....*
gi 446429071 609 LASANFRIGKYQEAVQNFEQALANN 633
Cdd:COG5010  128 LAALLLSLGQDDEAKAALQRALGTS 152
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
542-631 4.28e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 48.76  E-value: 4.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 542 QAYDNK-KYTKAEEAVGHAIAVKGKD-EAYLQLATIYVAEGKNKIAIDYITKLIkdrEIDKENNEAAYLLASANFRIGKY 619
Cdd:COG4785   81 VAYDSLgDYDLAIADFDQALELDPDLaEAYNNRGLAYLLLGDYDAALEDFDRAL---ELDPDYAYAYLNRGIALYYLGRY 157

                         90
                 ....*....|..
gi 446429071 620 QEAVQNFEQALA 631
Cdd:COG4785  158 ELAIADLEKALE 169
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 801-877 5.62e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.72  E-value: 5.62e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446429071 801 TRDINTLVNIGILYDKVGQGNEAEKLFTEAYSQNDENPHVNFAFGMFKIKQKKYEEASRFLRKTVQANENESEVRAA 877
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLN 77
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
36-165 6.90e-06

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 49.63  E-value: 6.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  36 EGRQGTVYQLQHENGMERIALKVFKERYREEKHQLA-FLKPLSSIAGLKvcSRYIVTkeehISAIEKSEDLAnSIVMPWV 114
Cdd:COG0515   17 RGGMGVVYLARDLRLGRPVALKVLRPELAADPEARErFRREARALARLN--HPNIVR----VYDVGEEDGRP-YLVMEYV 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446429071 115 EGPTWADILQEQRMLSKEQCFFIAEAFLTTLKMMEENEVAHNDLSSSNVLI 165
Cdd:COG0515   90 EGESLADLLRRRGPLPPAEALRILAQLAEALAAAHAAGIVHRDIKPANILL 140
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 541-632 9.15e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 45.37  E-value: 9.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 541 RQAYDNKKYTKAEEAVGHAIAVKGK----DEAYLQLATIYVAEGKNKIAIDYITKLIKDREIDKENNEAAYLLASANFRI 616
Cdd:COG1729    1 KALLKAGDYDEAIAAFKAFLKRYPNsplaPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALLKLGLSYLEL 80

                         90
                 ....*....|....*.
gi 446429071 617 GKYQEAVQNFEQALAN 632
Cdd:COG1729   81 GDYDKARATLEELIKK 96
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 601-711 1.07e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.77  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 601 ENNEAAYLLASANFRIGKYQEAVQNFEQALAnnakgIEPYKKDAMRDLAVSHMKMKEFEKAEDVIvKMSTKTNEDKAIVS 680
Cdd:COG4235   15 NDAEGWLLLGRAYLRLGRYDEALAAYEKALR-----LDPDNADALLDLAEALLAAGDTEEAEELL-ERALALDPDNPEAL 88

                         90       100       110
                 ....*....|....*....|....*....|.
gi 446429071 681 YLKGQLSTATVQLDKAESFFKEAIMQDSKNA 711
Cdd:COG4235   89 YLLGLAAFQQGDYAEAIAAWQKLLALLPADA 119
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 643-793 1.19e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.95  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 643 DAMRDLAVSHMKMKEFEKAEDVIVKMsTKTNEDKAIVSYLKGQLSTATVQLDKAESFFKEAIMQDSKNAIYTIELSNLYV 722
Cdd:COG4783    5 EALYALAQALLLAGDYDEAEALLEKA-LELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALL 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446429071 723 lwnktnlidSAKKeinYQQASHILQVAIQKDMKNIELLNQLGIVYYEAGQFYETRdgakstAAYQQALEAY 793
Cdd:COG4783   84 ---------KAGD---YDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAI------AALEKALELD 136
TPR_19 pfam14559
Tetratricopeptide repeat;
818-881 1.44e-05

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 43.34  E-value: 1.44e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446429071  818 GQGNEAEKLFTEAYSQNDENPHVNFAFGMFKIKQKKYEEASRFLRKTVQANENESEVRAAQEKL 881
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALLAKL 65
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
749-838 1.55e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 47.22  E-value: 1.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 749 AIQKDMKNIELLNQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVSSGTRDINTLVNIGILYDKVGQGNEAEKLFT 828
Cdd:COG4785   99 ALELDPDLAEAYNNRGLAYLLLGD-------------YDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLE 165

                         90
                 ....*....|
gi 446429071 829 EAYSQNDENP 838
Cdd:COG4785  166 KALELDPNDP 175
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 570-636 1.99e-05

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 43.09  E-value: 1.99e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446429071  570 LQLATIYVAEGKNKIAIDYITKLIKDREIDKENNEAAYLLASANFRIGKYQEAVQNFEQALANNAKG 636
Cdd:pfam13432   1 LALARAALRAGDYDDAAAALEAALARFPESPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGD 67
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 549-695 2.45e-05

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 46.56  E-value: 2.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  549 YTKAEEAVGHAIAVKGKDE-AYLQLATIYVAEGKNKIAIDYITKL--IKDREIDKENNEAAYLlasanFRIGKYQEAVQN 625
Cdd:TIGR02521  47 LEVAKENLDKALEHDPDDYlAYLALALYYQQLGELEKAEDSFRRAltLNPNNGDVLNNYGTFL-----CQQGKYEQAMQQ 121

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446429071  626 FEQALANNAKGiEPYkkDAMRDLAVSHMKMKEFEKAEdVIVKMSTKTNEDK-------AIVSYLKGQLSTATVQLDK 695
Cdd:TIGR02521 122 FEQAIEDPLYP-QPA--RSLENAGLCALKAGDFDKAE-KYLTRALQIDPQRpesllelAELYYLRGQYKDARAYLER 194
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 762-868 3.08e-05

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 46.18  E-value: 3.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  762 QLGIVYYEAGQFyetrdgAKSTAAYQQALEaynrvvsSGTRDINTLVNIGILYDKVGQGNEAEKLFTEAYSQNDENPHVN 841
Cdd:TIGR02521  36 QLALGYLEQGDL------EVAKENLDKALE-------HDPDDYLAYLALALYYQQLGELEKAEDSFRRALTLNPNNGDVL 102

                          90       100
                  ....*....|....*....|....*..
gi 446429071  842 FAFGMFKIKQKKYEEASRFLRKTVQAN 868
Cdd:TIGR02521 103 NNYGTFLCQQGKYEQAMQQFEQAIEDP 129
TPR_12 pfam13424
Tetratricopeptide repeat;
759-831 5.95e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.99  E-value: 5.95e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446429071  759 LLNQLGIVYYEAGQFYETRdgakstAAYQQALEAYNRVVSSGTRDI-NTLVNIGILYDKVGQGNEAEKLFTEAY 831
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEAL------ELLEKALEIARRLLGPDHPLTaTTLLNLGRLYLELGRYEEALELLERAL 72
STKc_PknB_like cd14014
Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs ...
 36-165 7.19e-05

Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270916 [Multi-domain]  Cd Length: 260  Bit Score: 45.27  E-value: 7.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  36 EGRQGTVYQLQHENGMERIALKVFKERYREEKHQLA-FLKPLSSIAGLKvcSRYIVTkeehISAIEKSEDLAnSIVMPWV 114
Cdd:cd14014   10 RGGMGEVYRARDTLLGRPVAIKVLRPELAEDEEFRErFLREARALARLS--HPNIVR----VYDVGEDDGRP-YIVMEYV 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446429071 115 EGPTWADILQEQRMLSKEQCFFIAEAFLTTLKMMEENEVAHNDLSSSNVLI 165
Cdd:cd14014   83 EGGSLADLLRERGPLPPREALRILAQIADALAAAHRAGIVHRDIKPANILL 133
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 552-707 1.14e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.41  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 552 AEEAVGHAIAVKGKDEAYLQLATIYVAEGKNKIAIDYITKLIKDREIDKENNEAAYLLASANFRIGKYQEAVQNFEQALA 631
Cdd:COG5010    3 ALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQ 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446429071 632 nnakgIEPYKKDAMRDLAVSHMKMKEFEKAEDVIVKmSTKTNEDKAIVSYLKGQLSTATVQLDKAESFFKEAIMQD 707
Cdd:COG5010   83 -----LDPNNPELYYNLALLYSRSGDKDEAKEYYEK-ALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 535-857 1.37e-04

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 45.75  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  535 KFMEQARQAYDNKKYTKAEEAVGHAIAVKGKDEAYLQLATIYVAEGKNKIAIDYITKLIkdrEIDKENNEAAYLLASANF 614
Cdd:TIGR00990 129 KLKEKGNKAYRNKDFNKAIKLYSKAIECKPDPVYYSNRAACHNALGDWEKVVEDTTAAL---ELDPDYSKALNRRANAYD 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  615 RIGKYQEAVQNFEQALAN---NAKGIEPYKKDAMRDLAVSHMKmkefEKAEDVIVKMSTKTN-----------------E 674
Cdd:TIGR00990 206 GLGKYADALLDLTASCIIdgfRNEQSAQAVERLLKKFAESKAK----EILETKPENLPSVTFvgnylqsfrpkprpaglE 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  675 DKAIVS----------YLKGQLSTATVQLDKAESFFKEAIMQDS--KNAIYTIELSNLY-VLWNK-TNLIDSAKKEINYQ 740
Cdd:TIGR00990 282 DSNELDeetgngqlqlGLKSPESKADESYEEAARAFEKALDLGKlgEKEAIALNLRGTFkCLKGKhLEALADLSKSIELD 361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  741 QA---SHILQVAIQKDM-----------KNIELLNQLGIVYYEAGQFYETRdgakstAAYQQALEAYNRVVSSGTRDINT 806
Cdd:TIGR00990 362 PRvtqSYIKRASMNLELgdpdkaeedfdKALKLNSEDPDIYYHRAQLHFIK------GEFAQAGKDYQKSIDLDPDFIFS 435

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 446429071  807 LVNIGILYDKVGQGNEAEKLFTEAYSQNDENPHVNFAFGMFKIKQKKYEEA 857
Cdd:TIGR00990 436 HIQLGVTQYKEGSIASSMATFRRCKKNFPEAPDVYNYYGELLLDQNKFDEA 486
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 757-876 1.53e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.03  E-value: 1.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 757 IELLNQLGIVYYEAGQFYETRDGAKSTAAYQQALEAYNRVVSSGTRDINTLVNIGILYDKVGQGNEAEKLFTEAYSQNDE 836
Cdd:COG5010    7 FDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPN 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446429071 837 NPHVNFAFGMFKIKQKKYEEASRFLRKTVQANENESEVRA 876
Cdd:COG5010   87 NPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYS 126
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
738-836 4.17e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.15  E-value: 4.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 738 NYQQASHILQVAIQKDMKNIELLNQLGIVYYEAGQfyetrdgakstaaYQQALeAYNRVVSSGTRDINTLVNIGILYDKV 817
Cdd:COG3063    7 DLEEAEEYYEKALELDPDNADALNNLGLLLLEQGR-------------YDEAI-ALEKALKLDPNNAEALLNLAELLLEL 72

                         90
                 ....*....|....*....
gi 446429071 818 GQGNEAEKLFTEAYSQNDE 836
Cdd:COG3063   73 GDYDEALAYLERALELDPS 91
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
614-704 4.33e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.15  E-value: 4.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 614 FRIGKYQEAVQNFEQALAnnakgIEPYKKDAMRDLAVSHMKMKEFEKAEDviVKMSTKTNEDKAIVSYLKGQLSTATVQL 693
Cdd:COG3063    3 LKLGDLEEAEEYYEKALE-----LDPDNADALNNLGLLLLEQGRYDEAIA--LEKALKLDPNNAEALLNLAELLLELGDY 75

                         90
                 ....*....|.
gi 446429071 694 DKAESFFKEAI 704
Cdd:COG3063   76 DEALAYLERAL 86
TPR1 COG4649
TPR-like repeat domain [Function unknown];
507-661 7.47e-04

TPR-like repeat domain [Function unknown];


Pssm-ID: 443687 [Multi-domain]  Cd Length: 222  Bit Score: 41.77  E-value: 7.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 507 ILIIGSTVVVVIG-GSTLFYFYTTNAKYQKF---MEQARQAYDNKKYTKAEEAVGhAIAVKGKDE----AYLQLATIYVA 578
Cdd:COG4649   29 PWIIGAAVLVVVGvAGWRGWRYWQEAQAEAAgdaYLAALELAEAGDAAEAAAALA-ALAADGPGGyaalARLRAAALLAQ 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 579 EGKNKIAIDYITKLIKDREIDKENNEAAYLLAsANFRIGkyQEAVQNFEQALANNAKGIEPYKKDAMRDLAVSHMKMKEF 658
Cdd:COG4649  108 AGDTAAAVAAYDAVAADASAPPLLRDLARLRA-ALLLVD--TGDPADVRARLEPLAAPGNPWRHSARELLALAALKAGDT 184


                 ...
gi 446429071 659 EKA 661
Cdd:COG4649  185 DAA 187
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
590-704 7.82e-04

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 42.18  E-value: 7.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 590 TKLIKDREIDKENNEAAY---LLASANFRIGKYQEAVQNFEQALannaKGIEPYKKDAMRDLAVSHMKMKEFEKAEDVIV 666
Cdd:COG4700   73 GRELRELEKALEFADTVQnrvRLADALLELGRYDEAIELYEEAL----TGIFADDPHILLGLAQALFELGRYAEALETLE 148

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446429071 667 KMSTKTNE-DKAIVSYLKGQLSTATVQLDKAESFFKEAI 704
Cdd:COG4700  149 KLIAKNPDfKSSDAHLLYARALEALGDLEAAEAELEALA 187
TPR_19 pfam14559
Tetratricopeptide repeat;
617-686 9.62e-04

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 38.33  E-value: 9.62e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  617 GKYQEAVQNFEQALAnnakgIEPYKKDAMRDLAVSHMKMKEFEKAEDVIVKMSTKTNEDKAiVSYLKGQL 686
Cdd:pfam14559   2 GDYAEALELLEQALA-----EDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPR-YAALLAKL 65
STKc_ULK1 cd14202
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the ...
 58-165 1.28e-03

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. It associates with three autophagy-related proteins (Atg13, FIP200 amd Atg101) to form the ULK1 complex. All fours proteins are essential for autophagosome formation. ULK1 is regulated by both mammalian target-of rapamycin complex 1 (mTORC1) and AMP-activated protein kinase (AMPK). mTORC1 negatively regulates the ULK1 complex in a nutrient-dependent manner while AMPK stimulates autophagy by inhibiting mTORC1. ULK1 also plays neuron-specific roles and is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, neurite extension, and axon branching. The ULK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271104 [Multi-domain]  Cd Length: 267  Bit Score: 41.53  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  58 VFKERYREeKHQLAF---------LKPLSSIAG--LKVCSRYivtKEEHISAIEKSEDLANSI--VMPWVEGPTWADILQ 124
Cdd:cd14202   18 VFKGRHKE-KHDLEVavkcinkknLAKSQTLLGkeIKILKEL---KHENIVALYDFQEIANSVylVMEYCNGGDLADYLH 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446429071 125 EQRMLSKEQCFFIAEAFLTTLKMMEENEVAHNDLSSSNVLI 165
Cdd:cd14202   94 TMRTLSEDTIRLFLQQIAGAMKMLHSKGIIHRDLKPQNILL 134
PTK_Jak_rpt1 cd05037
Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak ...
 107-286 1.52e-03

Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily is composed of Jak1, Jak2, Jak3, TYK2, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. The pseudokinase domain shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. It modulates the kinase activity of the C-terminal catalytic domain. In the case of Jak2, the presumed pseudokinase (repeat 1) domain exhibits dual-specificity kinase activity, phosphorylating two negative regulatory sites in Jak2: Ser523 and Tyr570. Most Jaks are expressed in a wide variety of tissues, except for Jak3, which is expressed only in hematopoietic cells. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). Jaks are also involved in regulating the surface expression of some cytokine receptors. The Jak-STAT pathway is involved in many biological processes including hematopoiesis, immunoregulation, host defense, fertility, lactation, growth, and embryogenesis. The Jak subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270633 [Multi-domain]  Cd Length: 259  Bit Score: 41.31  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 107 NSIVMPWVE-GP--TWadiLQEQRMLSKEQCFF-IAEAFLTTLKMMEENEVAHNDLSSSNVLIpfLSENPIEGQHYIELV 182
Cdd:cd05037   76 NIMVQEYVRyGPldKY---LRRMGNNVPLSWKLqVAKQLASALHYLEDKKLIHGNVRGRNILL--AREGLDGYPPFIKLS 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 183 D--VEQMYGPKTKRPSLLPagsaGYAPMYLKSGV--WQKEADRFAGAILLGEILSWCSEEvrnkkwtdasyFKTEEMQKE 258
Cdd:cd05037  151 DpgVPITVLSREERVDRIP----WIAPECLRNLQanLTIAADKWSFGTTLWEICSGGEEP-----------LSALSSQEK 215

                        170       180
                 ....*....|....*....|....*...
gi 446429071 259 CERYTLLQQVLHNQWnGEIAKLFKQAWS 286
Cdd:cd05037  216 LQFYEDQHQLPAPDC-AELAELIMQCWT 242
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
565-663 1.95e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 40.67  E-value: 1.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 565 KDEAYLQLATIYVAEGKNKIAIDYITKLIKDREIDKENNEAAYL-LASANFRIGKYQEAVQNFEQALAnnakgIEPYKKD 643
Cdd:COG4785   34 VLALAIALADLALALAAAALAAAALAAERIDRALALPDLAQLYYeRGVAYDSLGDYDLAIADFDQALE-----LDPDLAE 108

                         90       100
                 ....*....|....*....|
gi 446429071 644 AMRDLAVSHMKMKEFEKAED 663
Cdd:COG4785  109 AYNNRGLAYLLLGDYDAALE 128
TPR_21 pfam09976
Tetratricopeptide repeat-like domain; This family resembles a single unit of a TPR repeat.
 499-631 2.37e-03

Tetratricopeptide repeat-like domain; This family resembles a single unit of a TPR repeat.


Pssm-ID: 430959 [Multi-domain]  Cd Length: 194  Bit Score: 40.26  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  499 WWKKNKKRILIIgstVVVVIGGSTLFYFYTTNAKYQKfmEQARQAYDN-------KKYTKAEEAVGhAIAVKGKDEAY-- 569
Cdd:pfam09976   3 WWKENGKLIIIG---VVIGLGGLFGWNGWQYYQRSQA--EEASALYQQlleavaaGDAAKAQAAAA-QLKDEYGGTGYaa 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446429071  570 ---LQLATIYVAEGKNKIAIDYITKLIkdreidkENNEAAYLLASANFRIGKYQEAVQNFEQALA 631
Cdd:pfam09976  77 laaLLLAKAAVEAGDLAAAKAQLEWVA-------DNAKDEALKALARLRLARVLLAQGKYDEALK 134
Pkinase pfam00069
Protein kinase domain;
36-184 3.01e-03

Protein kinase domain;


Pssm-ID: 459660 [Multi-domain]  Cd Length: 217  Bit Score: 39.92  E-value: 3.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071   36 EGRQGTVYQLQHENGMERIALK-VFKERYREEKHQLAflkpLSSIAGLKVCS-RYIVTkeeHISAIEKSEDLanSIVMPW 113
Cdd:pfam00069   9 SGSFGTVYKAKHRDTGKIVAIKkIKKEKIKKKKDKNI----LREIKILKKLNhPNIVR---LYDAFEDKDNL--YLVLEY 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446429071  114 VEGPTWADILQEQRMLSKEQCFFIaeaFLTTLKMMEENEVAHNDLSSSNVLIPFLsenpIEGQHYIELVDV 184
Cdd:pfam00069  80 VEGGSLFDLLSEKGAFSEREAKFI---MKQILEGLESGSSLTTFVGTPWYMAPEV----LGGNPYGPKVDV 143
PKc_MAPKK_plant_like cd06623
Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and ...
 34-165 3.54e-03

Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include MAPKKs from plants, kinetoplastids, alveolates, and mycetozoa. The MAPKK, LmxPK4, from Leishmania mexicana, is important in differentiation and virulence. Dictyostelium discoideum MEK1 is required for proper chemotaxis; MEK1 null mutants display severe defects in cell polarization and directional movement. Plants contain multiple MAPKKs like other eukaryotes. The Arabidopsis genome encodes for 10 MAPKKs while poplar and rice contain 13 MAPKKs each. The functions of these proteins have not been fully elucidated. There is evidence to suggest that MAPK cascades are involved in plant stress responses. In Arabidopsis, MKK3 plays a role in pathogen signaling; MKK2 is involved in cold and salt stress signaling; MKK4/MKK5 participates in innate immunity; and MKK7 regulates basal and systemic acquired resistance. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132954 [Multi-domain]  Cd Length: 264  Bit Score: 40.27  E-value: 3.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  34 GQeGRQGTVYQLQHENGMERIALKVFKErYREEKHQLAFLKPLSSIagLKVCSRYIVTKEEhisAIEKSEDLanSIVMPW 113
Cdd:cd06623   10 GQ-GSSGVVYKVRHKPTGKIYALKKIHV-DGDEEFRKQLLRELKTL--RSCESPYVVKCYG---AFYKEGEI--SIVLEY 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446429071 114 VEGPTWADILQEQRMLSKEQCFFIAE------AFL-TTLKMMeenevaHNDLSSSNVLI 165
Cdd:cd06623   81 MDGGSLADLLKKVGKIPEPVLAYIARqilkglDYLhTKRHII------HRDIKPSNLLI 133
TPR_12 pfam13424
Tetratricopeptide repeat;
568-631 3.63e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.98  E-value: 3.63e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446429071  568 AYLQLATIYVAEGKNKIAIDYITKLIKDREIDKENN-----EAAYLLASANFRIGKYQEAVQNFEQALA 631
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDhpltaTTLLNLGRLYLELGRYEEALELLERALA 73
TPR_12 pfam13424
Tetratricopeptide repeat;
605-663 3.70e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 36.98  E-value: 3.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446429071  605 AAYLLASANFRIGKYQEAVQNFEQALANNAKGIEPYKKD---AMRDLAVSHMKMKEFEKAED 663
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLtatTLLNLGRLYLELGRYEEALE 66
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
813-875 4.38e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 4.38e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446429071 813 LYDKVGQGNEAEKLFTEAYSQNDENPHVNFAFGMFKIKQKKYEEASRFlRKTVQANENESEVR 875
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEAL 62
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 681-798 5.45e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.06  E-value: 5.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 681 YLKGQLSTATVQLDKAESFFKEAIMQDSKNAIYTIELSNLYVLWNktnlidsakkeiNYQQASHILQVAIQKDMKNIELL 760
Cdd:COG4235   21 LLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAG------------DTEEAEELLERALALDPDNPEAL 88

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446429071 761 NQLGIVYYEAGQfyetrdgakstaaYQQALEAYNRVVS 798
Cdd:COG4235   89 YLLGLAAFQQGD-------------YAEAIAAWQKLLA 113
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 550-867 6.71e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 6.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  550 TKAEEAVGHAIAVKGK-DEAYLQLATIYVAEGKNKIAIDYITKLIKDreidKENNEAAY-LLASANFRIGKYQEAVQNFE 627
Cdd:TIGR02917 414 SEAIADLETAAQLDPElGRADLLLILSYLRSGQFDKALAAAKKLEKK----QPDNASLHnLLGAIYLGKGDLAKAREAFE 489

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  628 QALAnnakgIEPYKKDAMRDLAVSHMKMKEFEKAEDVIVKMSTKTNEDKAIVSYLKGqLSTATVQLDKAESFFKEAIMQD 707
Cdd:TIGR02917 490 KALS-----IEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAG-LYLRTGNEEEAVAWLEKAAELN 563

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  708 SKNAIYTIELSNLYVLWNKT--------NLIDSAKKEINY-------QQASHILQVAIQKDMKNIELLNQLGIVYYEAGQ 772
Cdd:TIGR02917 564 PQEIEPALALAQYYLGKGQLkkalailnEAADAAPDSPEAwlmlgraQLAAGDLNKAVSSFKKLLALQPDSALALLLLAD 643

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  773 FYET-RDGAKSTAAYQQALEAYNRvvssgtrdiNTLVNIGI--LYDKVGQGNEAEKLFTEAYSQNDENPHVNFAFGMFKI 849
Cdd:TIGR02917 644 AYAVmKNYAKAITSLKRALELKPD---------NTEAQIGLaqLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYL 714

                         330
                  ....*....|....*...
gi 446429071  850 KQKKYEEASRFLRKTVQA 867
Cdd:TIGR02917 715 RQKDYPAAIQAYRKALKR 732
BamD COG4105
Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope ...
 501-662 7.29e-03

Outer membrane protein assembly factor BamD, BamD/ComL family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443281 [Multi-domain]  Cd Length: 254  Bit Score: 39.09  E-value: 7.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 501 KKNKKRILIIgsTVVVVIGGSTLFYFYTTNAKYQKFMEQARQAYDNKKYTKAE---EAV-----GHAIAvkgkDEAYLQL 572
Cdd:COG4105    2 KKLLKLLLLL--LLALLLAGCSSFKKALKSWDAEELYEEAKEALEKGDYEKAIklfEELeprypGSPYA----EQAQLML 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 573 ATIYVAEGKNKIAIDYITKLIK----DREIDkennEAAYLLASANFRIGK--------YQEAVQNFEQALANNAKGiePY 640
Cdd:COG4105   76 AYAYYKQGDYEEAIAAADRFIKlypnSPNAD----YAYYLRGLSYYEQSPdsdrdqtsTRKAIEAFQELINRYPDS--EY 149

                        170       180
                 ....*....|....*....|....
gi 446429071 641 KKDA--MRDLAVSHMKMKEFEKAE 662
Cdd:COG4105  150 AEDAkkRIDELRDKLARKELEVAR 173
STKc_ULK1_2-like cd14120
Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar ...
 58-181 8.19e-03

Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. ULK2 is ubiquitously expressed and is essential in autophagy induction. ULK1 and ULK2 have unique and cell-type specific roles, but also display partially redundant roles in starvation-induced autophagy. They both display neuron-specific functions: ULK1 is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, and axon branching; ULK2 plays a role in axon development. The ULK1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271022 [Multi-domain]  Cd Length: 256  Bit Score: 38.89  E-value: 8.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071  58 VFKERYREEKHQLAFLKPLSSIAGLKvcSRYIVTKE---------EHISAIEKSEDLANSI--VMPWVEGPTWADILQEQ 126
Cdd:cd14120    9 VFKGRHRKKPDLPVAIKCITKKNLSK--SQNLLGKEikilkelshENVVALLDCQETSSSVylVMEYCNGGDLADYLQAK 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446429071 127 RMLSKE--QCFF--IAEAflttLKMMEENEVAHNDLSSSNVLipfLSENPIEGQHYIEL 181
Cdd:cd14120   87 GTLSEDtiRVFLqqIAAA----MKALHSKGIVHRDLKPQNIL---LSHNSGRKPSPNDI 138
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 786-884 9.68e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.89  E-value: 9.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446429071 786 YQQALEAYNRVVS---SGTRDINTLVNIGILYDKVGQGNEAEKLFTEAYSQNDENPHVNFAfgMFKI-----KQKKYEEA 857
Cdd:COG1729    9 YDEAIAAFKAFLKrypNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDA--LLKLglsylELGDYDKA 86

                         90       100
                 ....*....|....*....|....*..
gi 446429071 858 SRFLRKTVQANENESEVRAAQEKLTEM 884
Cdd:COG1729   87 RATLEELIKKYPDSEAAKEARARLARL 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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