|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
10-400 |
2.86e-70 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 226.34 E-value: 2.86e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 10 IKIRIITSFLTRTVSTMIFPFMAIYFS--IKLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIA 87
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHqqLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 88 CMGIANSdyvdsPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYRLQL 167
Cdd:cd17329 81 LLGFAHS-----PWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 168 FIGLTVIAVITLYVMAVYMEEvyvaRKIVEKKNVLKDMADSYKVVMKDKAFLIFCAASICTLSLEFQINNYLGVRLqkef 247
Cdd:cd17329 156 FLAAAVLFLLAALVLLFLLPE----TRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYV---- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 248 etvhflfgngVTFDLTGIRMLSWISAENTILVVLCSALLIKMLKSFNDLKILYVGLFIYTIGFTILGTSNSLWILLIAGL 327
Cdd:cd17329 228 ----------VEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMI 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446430331 328 FQTVGEMMYVPVRQSIMADMVPNEARGSYMAINGMVFQVAKMNG-ALGVMLGSFIASWGMSALYFIVGMSSILL 400
Cdd:cd17329 298 VLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGpLVGGLLLDLLGPGLPWLILAALGLIAAAL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-367 |
4.28e-29 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 116.23 E-value: 4.28e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 14 IITSFLTRTVSTMIFPFMAIYF-SIKLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIA 92
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAaDLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 93 nsdyvDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYRLQ-LFIGL 171
Cdd:COG2814 96 -----PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRwVFLVN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 172 TVIAVITLYVMAVYMEEVYVARKivekknvlKDMADSYKVVMKDKAFLIFCAASICTLSLEFQINNYLGVRLQKEFetvh 251
Cdd:COG2814 171 AVLALLALLLLLRLLPESRPAAR--------ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL---- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 252 flfgnGVTFDLTGirmlsWISAENTILVVLCSALLIKMLKSFNDLKILYVGLFIYTIGFTILGTSNSLWILLIAGLFQTV 331
Cdd:COG2814 239 -----GLSASAAG-----LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGF 308
|
330 340 350
....*....|....*....|....*....|....*.
gi 446430331 332 GEMMYVPVRQSIMADMVPNEARGSYMAINGMVFQVA 367
Cdd:COG2814 309 GFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-399 |
9.34e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 104.58 E-value: 9.34e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 15 ITSFLTRTVSTMIFPFMAIYF-SIKLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIAN 93
Cdd:cd17325 3 LALFLDMLGYGIIIPILPLYAeSLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 94 SdyvdsPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYRLQ-LFIGLT 172
Cdd:cd17325 83 S-----YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRaPFLVCA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 173 VIAVITLYVMAVYMEEVYVARKivEKKNVLKDMADSYKVVMKDKAFLIFCAAsICTLSLEFQInnylgvrlqkeFETVHF 252
Cdd:cd17325 158 ALALLALVLALLLLPEPRPPPN--KRAVSAARLRSGLRLLLRDRRLLALFLA-IFVLAFAFGA-----------LEPFLP 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 253 LFGNGVtFDLTgIRMLSWISAENTILVVLCSALLIKMLKSFNDLKILYVGLFIYTIGFTILGTSNSLWILLIAGLFQTVG 332
Cdd:cd17325 224 LYAAEL-GGLS-PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLG 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446430331 333 EMMYVPVRQSIMADMVPNEARGSYMAINGMVFQVAKMNGALgvMLGSFIASWGMSALYFIVGMSSIL 399
Cdd:cd17325 302 LGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPL--LGGFLYDAFGFATPFLAAAALLLL 366
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-367 |
2.85e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 91.33 E-value: 2.85e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 14 IITSFLTRTVSTMIFPFMAIYFSIKLG--SAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGI 91
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGisPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 92 ANSDyvdspWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYRLQLFIGL 171
Cdd:pfam07690 82 ASSL-----WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 172 TVIAVITLYVMAVYMEEVYVARKIVEKKNVLKDMADSYKVVMKDKAFLIFcAASICTLSLEFQINNYLGVrlqkefetVH 251
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLL-LALLLFGFAFFGLLTYLPL--------YQ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 252 FLFGNGVTFDLTGIRMLSWISaentILVVLCSALLIKMLKSFNDLKILYVGLFIYTIGFTILGTSNSLWILLIAGLFQTV 331
Cdd:pfam07690 228 EVLGLSALLAGLLLGLGGLLG----AIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGF 303
|
330 340 350
....*....|....*....|....*....|....*.
gi 446430331 332 GEMMYVPVRQSIMADMVPNEARGSYMAINGMVFQVA 367
Cdd:pfam07690 304 GFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
40-402 |
7.20e-20 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 90.37 E-value: 7.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 40 GSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIANSDYVDSPWLTFIFMLVNSLGSGLMNP 119
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 120 ATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYRLQLFIGLTVIAVITLYVMAVYMEEVYVARKIVEKK 199
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 200 NVLKDMADSYKVVMKDK----AFLIFCAASICTLSLEFQINNYLGVRLQKefetvhflfgngvtfdltGIRMLSWISAEN 275
Cdd:cd06173 192 LLLRDLREGLRYLRRSPllrlLLLALALFALLGGALTVLLPLLAKEVLGG------------------GAAGYGLLLAAF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 276 TILVVLCSALLIKMLKSFNDLKILYVGLFIYTIGFTILGTSNSLWILLIAGLFQTVGEMMYVPVRQSIMADMVPNEARGS 355
Cdd:cd06173 254 GVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGR 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 446430331 356 YMAINGMVFQVAkmnGALGVMLGSFIAS-WGMSALYFIVGMSSILLFM 402
Cdd:cd06173 334 VFSVYNALNSGA---MPLGALLAGLLADaLGLSAVFLLAGALLLLAAL 378
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
14-401 |
4.35e-19 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 88.03 E-value: 4.35e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 14 IITSFLTRTVSTMIFPFMAIYFSIKLGS-AIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIA 92
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSeAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 93 NsdyvdSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYRLQLFIGLT 172
Cdd:cd17489 82 T-----SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 173 VIAVITLYVMAVYMEEVYVARKIVEKKNVLKDMADSYKVVMKDKAFLIFCAASICTLSlefqinNYLGvrlqkefetvhf 252
Cdd:cd17489 157 AVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAIS------TFLP------------ 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 253 LFGNGVTFDLTGIrmlswISAENTILVVLCSALLIKMLKSFNDLKILYVGLFIYTIGFTILGTSNSLWILLIAGLFQTVG 332
Cdd:cd17489 219 LYAAERGISNAGL-----FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLG 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446430331 333 EMMYVPVRQSIMADMVPNEARGSYMAINGMVFQVAKmnGALGVMLGSFIASWGMSALYFIVGMSSILLF 401
Cdd:cd17489 294 FGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGI--GLGGLLLGLVAELFGYRAMFLLAAVVVLLAL 360
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
17-400 |
5.83e-18 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 84.93 E-value: 5.83e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 17 SFLTRTVSTMIFPFMAIYFSIklGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGqsIQVISIACMGIANSDy 96
Cdd:cd17474 11 AVLGVSIVDPILPAIAEALGA--SPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPG--LLLFGIGGLLCGLSD- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 97 vdSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYRLQLFIGLTVIAV 176
Cdd:cd17474 86 --SFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 177 ITLYVMAVYMEEvyvarKIVEKKNVLKDMADSYKVVMKDKAFLIFCAASICTLSLEFQINNYLGVRLQKEFetvhflfgn 256
Cdd:cd17474 164 VAFLAILFLLPE-----PKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLY--------- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 257 GVTFDLTGIRMLSWisaenTILVVLCSALLIKMLKS-FNDLKILYVGLFIYTIGFTILGTSNSLWILLIAGLFQTVGEMM 335
Cdd:cd17474 230 GISPIIIGLLFAGW-----SVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGL 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446430331 336 YVPVRQSIMADMVPNEARGSYMAINGMVFQVAkmnGALGVMLGSFIASWGMSALYFIVGMSSILL 400
Cdd:cd17474 305 NLPLLTTLVTELAPEEERGTASSLYNFVRFLG---QAVGPLLFGLLLEIFGLSAPFLVGAAIALA 366
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-185 |
2.01e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.01 E-value: 2.01e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 1 MGFWSMHRNIKIRIITSFLTRTVSTMIFPFMAIYFS--IKLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIG 78
Cdd:cd17325 192 LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAelGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 79 QSIQVISIACMGiansdYVDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGL 158
Cdd:cd17325 272 LLLSAVALLLLP-----LATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGF 346
|
170 180
....*....|....*....|....*...
gi 446430331 159 LFENYRLQ-LFIGLTVIAVITLYVMAVY 185
Cdd:cd17325 347 LYDAFGFAtPFLAAAALLLLAAVLFLLL 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-384 |
5.36e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 79.01 E-value: 5.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 17 SFLTRTVSTMIFPFMAIYF-SIKLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIAnsd 95
Cdd:cd06174 5 FFLTGLARGLISPLLPALLqSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA--- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 96 yvDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYR---LQLFIGLT 172
Cdd:cd06174 82 --PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfgwRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 173 VIAVITLYVMAVYMEEVYVARKIVEKKNVLKDMADSYKVVMKDKAFLIFCAASICTLSLEFQINNYLGVrlqkefetvhF 252
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPL----------F 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 253 LFGNGVTFDLTGIRMLSWISAENTILVVLCSALlikMLKSFNDLKILYVGLFIYTIGFTILGTSNSLWILLIAGLFQTVG 332
Cdd:cd06174 230 LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLL---SDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFG 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446430331 333 EMMYVPVRQSIMADMVPNEARGSYMAINGMVfqvakmnGALGVMLGSFIASW 384
Cdd:cd06174 307 LGGLLPLSFALIAELFPPEIRGTAFGLLNTF-------GFLGGAIGPLLAGF 351
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
15-385 |
1.76e-15 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 78.02 E-value: 1.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 15 ITSFLTRTVSTMIFPFMAIYFSIKLG--SAIAGALLLINVIASLVIGLYGGYVGDRLG-----RKKVMIIGQSIQVISIA 87
Cdd:COG2211 17 LGDLGLNLAFGLLSAYLLYFYTDVLGlsAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 88 CMGIA-NSDYVDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVST-PENRKVMYSINYWAINLSIAIGAIFGGLLFENYR- 164
Cdd:COG2211 97 LLFTApDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGg 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 165 ------LQLFIGLTVIAVITLYVMAVYMEEVYVARKivEKKNVLKDMadsyKVVMKDKAFLIFCAASICTLSLEFQINNY 238
Cdd:COG2211 177 daalgyRLTALIFAVLGLLAFLLTFFGTKERPVPEE--EKVSLKESL----KALLKNRPFLLLLLAYLLFFLALALVAAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 239 LGVrlqkefeTVHFLFGNGVTfdltgirMLSWISAENTILVVLCSALLIKMLKSFNDLKILYVGLFIYTIGFTILG--TS 316
Cdd:COG2211 251 LLY-------YFKYVLGLSAA-------LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFflGP 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446430331 317 NSLWILLIAGLFQTVGEMMYVPVRQSIMADMVPNE-------ARGSYMAINGMVFqvaKMNGALGVMLGSFIASWG 385
Cdd:COG2211 317 GNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrREGLYFGIFTFAI---KLGQALAGALAGLLLALF 389
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
26-378 |
2.68e-12 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 67.78 E-value: 2.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 26 MIFPFMAIYFSIKLGSA--IAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIAnsdyvDSPWLT 103
Cdd:PRK11646 28 VVFPLISIRFVDQLGWAavMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMAIA-----HEPWLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 104 FIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGG-LLFENYRLQLFIGltviavITLYVM 182
Cdd:PRK11646 103 WLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSwLLQYDFRLVCATG------AVLFVL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 183 AVYMEEVYV-ARKIvekKNVLKDMADSYKVVMKDKAFLIFcaasICTLS----LEFQINNYLGVRLqkefetvhflfgNG 257
Cdd:PRK11646 177 AAAFNAWLLpAYKL---STVRTPVREGMTRVLRDKRFVTY----VLTLTgyymLAVQVMLMLPIMV------------ND 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 258 VTFDLTGIRmlsWISA-ENTILVVLCSALLIKMLKSFNDLKILYVGLFIYTIGFTILGTSNSL-WILLIAGLFQtVGEMM 335
Cdd:PRK11646 238 IAGSPSAVK---WMYAiEACLSLTLLYPIARWSEKRFRLEHRLMAGLLIMSLSMFPIGMVSNLqQLFTLICLFY-IGSII 313
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 446430331 336 YVPVRQSIMADMVPNEARGSYMAINgmvfqvaKMNGALGVMLG 378
Cdd:PRK11646 314 AEPARETLSASLADARARGSYMGFS-------RLGLALGGAIG 349
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
15-401 |
1.20e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 65.64 E-value: 1.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 15 ITSFLTRTVSTMIFPFMAIYFSIKLGSA-----IAGALLLINVIASLViglyGGYVGDRLG-RKKVMIIGQSIQVISIAC 88
Cdd:cd17370 6 LVSLFADISYEMARSILPLFLVVLGASAaavglIEGLAEALGSLLRLF----SGYLSDRTGkRKPLVILGYGLSALAKPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 89 MGIANSdyvdsPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLF----ENYR 164
Cdd:cd17370 82 LALAGS-----WQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLyllgGNYR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 165 LqLFIGLTVIAVITLYVmavymeeVYVARKIVEKKNVLKDMADSYKVVMKDKAFLIFCAASictlslefqinnylgvrlq 244
Cdd:cd17370 157 T-IFLLAAIPALLALLI-------LLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAV------------------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 245 kefetvhFLFGNG-VTFDLTGIR-MLSWISAENTILVVL-------CSALLIKMLK-SFNDLKILYVGLFIYTIGFTILG 314
Cdd:cd17370 210 -------ALFALGnFSFAFLILRaQELGLSAALIPLLYAlfnlvyaLAAYPAGRLSdRIGRKKLLILGYLSLALAYLGFA 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 315 TSNSLWILLIAGLFQTVGEMMYVPVRQSIMADMVPNEARGSYMAIngmvfqvakMNGALGVmlGSFIASWGMSALYFIVG 394
Cdd:cd17370 283 LGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGL---------FNTVVGI--GWLLASLIAGYLWDLIS 351
|
....*..
gi 446430331 395 MSSILLF 401
Cdd:cd17370 352 PSAAFLF 358
|
|
| PTR2 |
COG3104 |
Dipeptide/tripeptide permease [Amino acid transport and metabolism]; |
41-399 |
5.34e-11 |
|
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
Pssm-ID: 442338 [Multi-domain] Cd Length: 479 Bit Score: 64.07 E-value: 5.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 41 SAIAGALLLINVIASLVIGLY----------GGYVGDR-LGRKKVMIIGQSIQVISIACMGIANSDyvdspWLTFIFMLV 109
Cdd:COG3104 44 SLADGGLGLSEADAAAIYGAYtalvyltpllGGWLADRlLGQRRAILLGGILMALGHFLLALPGGV-----TLFYLGLAL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 110 NSLGSGLMNPATEAMLIDVSTPEN--RKVMYSINYWAINLSIAIGAIFGGLLFENY------------------------ 163
Cdd:COG3104 119 IAVGNGLFKPNISSLVGQLYDPGDprRDAGFTIFYMGINIGAFLAPLLCGYLGEKYgwhygfgaaaigmligliifllgr 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 164 ------------------RLQLFIGLTVIAVITLYVMAVYMEEVYVARKIVEKKNVLKDMADSYKVVMKDK----AFLIF 221
Cdd:COG3104 199 kylgdiglepdnplskkeRLIAVALGALLLVLVLAGLLSNANIANYLLYVIAIIAYFIFILRSKKLTKEERkrllAILIL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 222 CAASICTLSLEFQINNYLgvrlqkefetvhFLFG-NGVTFDLTGIRML-SWISAENTILVVLCS----ALLIKMLKSFND 295
Cdd:COG3104 279 FLFSIVFWALYEQAGTSL------------NLFAdRNVDRSLFGFEIPpSWFQSLNPLFIIILApvfaALWTKLGKRGKE 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 296 LKILY---VGLFIYTIGFTIL---------GTSNSLWILLIAGLFQTVGEMMYVPVRQSIMADMVPNEARGSYMAINGMV 363
Cdd:COG3104 347 PSTPTkfaLGLLLLGLGFLVMalaallagaGGKVSPLWLVLAYLLLTIGELCLSPVGLSMITKLAPARFAGQMMGLWFLA 426
|
410 420 430
....*....|....*....|....*....|....*.
gi 446430331 364 FQVAkmnGALGVMLGSFIASWGMSALYFIVGMSSIL 399
Cdd:COG3104 427 TALG---NLLAGLLAGLYAVPGYTAYFLLLGGIALV 459
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
30-186 |
1.59e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 62.23 E-value: 1.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 30 FMAIYFsIKLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIANSdyvdsPWLTFIFMLV 109
Cdd:cd17489 216 FLPLYA-AERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGS-----PWMLLLAAVL 289
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446430331 110 NSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYRLQ-LFIGLTVIAVITLYVMAVYM 186
Cdd:cd17489 290 YGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRaMFLLAAVVVLLALVLYIFLL 367
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
12-159 |
2.07e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 62.23 E-value: 2.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 12 IRIITSFLTRTVSTMIFPFMAIYF---SIKLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIAC 88
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALLLYYfkyVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446430331 89 MGIANSdyvDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRK-------VMYSINYWAINLSIAIGAIFGGLL 159
Cdd:COG2211 311 LFFLGP---GNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKtgrrregLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
267-401 |
9.12e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 59.60 E-value: 9.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 267 MLSWISAENTILVVLCSALLIKMLKSFNDLKILYVGLFIYTIGFTILGTSNSLWILLIAGLFQTVGEMMYVPVRQSIMAD 346
Cdd:COG2814 46 QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIAD 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 446430331 347 MVPNEARGSYMAINGMVFQVAkmnGALGVMLGSFIAS-WGMSALYFIVGMSSILLF 401
Cdd:COG2814 126 LVPPERRGRALGLLGAGLGLG---PALGPLLGGLLADlFGWRWVFLVNAVLALLAL 178
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
62-388 |
1.56e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 59.11 E-value: 1.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 62 GGYVGDRLGRKKVMIIGQSIQVISIACMGIANsdyvdSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSIN 141
Cdd:cd17321 51 AGRLGDRFGRKRVFLIGLALFGLASLLCALAP-----SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLW 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 142 YWAINLSIAIGAIFGGLLFEN------YRLQLFIGLTVIAVITLYVMAVYMeevyvarkivekknvlkdmadsykvvmkd 215
Cdd:cd17321 126 GAVVGIGAALGPLLGGLLLELfgwrwiFLINVPIGLVALLLARTFSGAVLA----------------------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 216 kAFLIFCAASICTLSLefqinnylgvrlqkefeTVHFLFGNGVTFDLTGIRMLSWisaenTILVVLCSALLIKMLKSFND 295
Cdd:cd17321 177 -AFLLGAALGGLLFLL-----------------PLYLQGVLGYSPLQAGLALLPL-----ALAMLVAAPLAGRLADRFGP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 296 LKILYVGLFIYTIGF---TILGTSNSLWILLIAGLFQTVGEMMYVPVRQSIMADMVPNEARGSYMAINGMVFQVAkmnGA 372
Cdd:cd17321 234 RLVLVAGLLLTAVGLlllALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLG---GA 310
|
330
....*....|....*.
gi 446430331 373 LGVMLGSFIASWGMSA 388
Cdd:cd17321 311 LGVALLGALLTAGLSA 326
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-399 |
1.89e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 58.73 E-value: 1.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 15 ITSFLTRTVSTMIFPFMAIYFSikLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIAns 94
Cdd:COG2271 20 FLNYLDRSNLSVAAPPLQADLG--LSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFA-- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 95 dyvDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYRLQ-LFIGLTV 173
Cdd:COG2271 96 ---TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRaAFLILGL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 174 IAVITLYVmavymeevyvarkivekknvlkdmadsykvvmkdkAFLIFCAASICTLSLEFQINNYLGVRLQKEFEtvhfl 253
Cdd:COG2271 173 PGLLLALL-----------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRG----- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 254 fgngvtFDLTGIRMLSWISAENTILVVLCSALLIKMLKSFNdLKILYVGLFIYTIGFTILGTSNSLWILLIAGLFQTVGE 333
Cdd:COG2271 213 ------LSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRR-KLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGL 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446430331 334 MMYVPVRQSIMADMVPNEARGSYMAINGMVFQVAkmnGALG-VMLGSFIASWGMSALYFIVGMSSIL 399
Cdd:COG2271 286 GGAFGLLWALAAELFPKKARGTASGLVNTFGFLG---GALGpLLVGYLLDATGYQAAFLLLAALALL 349
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
14-393 |
4.71e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 57.58 E-value: 4.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 14 IITSFLTRTVSTMI---FPFMAIYFSiKLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISiACMG 90
Cdd:cd17473 5 LLASTLTVMAGAAIapaLPAIAQHFV-PNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIG-GVAG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 91 IansdYVDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFE-NYRLQLFI 169
Cdd:cd17473 83 L----FLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEiGWRAPFLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 170 GLtvIAVITLYVMAVYMEEVYVARKIVEKKNVLKDMADSYKVVmkdkafLIFCAASICTLSLEFQINNYLGVRLQKEFet 249
Cdd:cd17473 159 YL--LALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRV------LPIYFLAFLAMLLFYVIPIQLPFLLQERG-- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 250 vhflfgngvtfdLTGIRMLSWISAENTILVVLCSALLIKMLKSFNDLKILYVGLFIYTIGFTILGTSNSLWILLIAGLFQ 329
Cdd:cd17473 229 ------------GGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILA 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446430331 330 TVGEMMYVPVRQSIMADMVPNEARGSYMAINGMVF---Q------VAKMNGALGVMLGSFIASWGMSALYFIV 393
Cdd:cd17473 297 GLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFflgQflsplvLGPLVNLTGGLSGAFLILGVLALVLAIV 369
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
15-401 |
5.38e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 57.20 E-value: 5.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 15 ITSFLTRTVSTMIFPFMA--IYFSIKLGSA--IAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMG 90
Cdd:cd17330 3 LVVFLDALGFGIVFPVLPfyVREFNKLGASgyYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 91 IANsdyvdSPWLTFIFMLVNSLGSGLmNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYRLQL-FI 169
Cdd:cd17330 83 LSR-----NLWLLFLARFLDGLTGGN-VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALpFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 170 GLTVIAVITLYVMAVYMEEVYVarkivekknvlkdmadsykvvmkdkAFLIFCAASICTLSLEFQINNYLGVRLQkeFET 249
Cdd:cd17330 157 VAAALALLNLVLVLFFLPPLRR-------------------------LLLVYFLIALAFAGLESVFSLFLKDRFG--FSP 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 250 VHFlfgnGVTFDLTGIrmlswisaentILVVLCSALLIKMLKSFNDLKILYVGLFIYTIGFTILGTSNSLWILLIAGLFQ 329
Cdd:cd17330 210 SQI----GLLLALVGI-----------AGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAIL 274
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446430331 330 TVGEMMYVPVRQSIMADMVPNEARGSYMAINGMVFQVAKMngaLGVMLGSFI-ASWGMSALYFIVGMSSILLF 401
Cdd:cd17330 275 AFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARI---IGPLLAGPLySFLGPGVPFLLAAGLLLIAL 344
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
14-325 |
7.90e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 57.17 E-value: 7.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 14 IITSFLTRTVSTMIfPFMAIYFSikLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIAN 93
Cdd:COG0738 18 FLWGFATALWGPLI-PALKDAFG--LSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAP 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 94 sdyvdSPWLTFIFMLVNSLGSGLMNPATEAMLIDVStPENRKVMYSINYWAINLSIAIGAIFGG-LLFENYRLQLFIGLT 172
Cdd:COG0738 95 -----SYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGlLILLGLSLSWHLPYL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 173 VIAVITLYVMAVYMeeVYVARKIVEKKNVLKDMADSYKVVMKDKAFLIFCAASICTLSLEFQINNYLGVRLQKEFETVHF 252
Cdd:COG0738 169 ILAVLLLLLALLFL--RSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEA 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446430331 253 LFGNGVTfdltgirmLSWISAenTILVVLCSALLIKmlksFNDLKILYVGLFIYTIGFTILGTSNSLWILLIA 325
Cdd:COG0738 247 TAALGLS--------LFWGGM--TIGRFLGGFLLKR----FGPVRLLRLSALLAAVGLLLALLAPGPWLALIG 305
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
22-188 |
1.17e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 55.97 E-value: 1.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 22 TVSTMIFPFMAIYFSikLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIAnsdyvDSPW 101
Cdd:COG0477 31 TIVNVALPSIAADLG--ASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA-----PSPE 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 102 LTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYRLQLFIGLTVIAVITLYV 181
Cdd:COG0477 104 LLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALV 183
|
....*..
gi 446430331 182 MAVYMEE 188
Cdd:COG0477 184 LRLRLPE 190
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
16-363 |
1.65e-08 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 55.79 E-value: 1.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 16 TSFLTRTVSTMIFPFMAIYFSiklGSA-IAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIANS 94
Cdd:TIGR00900 10 ISLIGTAITQVALPLYVLAGT---GSAsVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLVAVLPFVAL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 95 DYVDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYRLQLFIGLTVI 174
Cdd:TIGR00900 87 LGGLNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEEQLTQANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAIWVDAV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 175 AVI--TLYVMAVYMEEVYVARKIVEKKNVLKDMADSYKVVMKDKAFLifcaasicTLSLEFQINNYLGVrlqkEFETVHF 252
Cdd:TIGR00900 167 GFAisALLIVSVRIPELAASEIQALSNAVLRDTREGIKFVLKNPLLR--------TLLLLALLFNLVFA----PAIVALF 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 253 LFGNGVTFDLtGIRMLSWISAENTILVVLCSALLIKMLKSFNDLKILYVGLFIYTIGFTILGTSNS-LWILLIAGLFQTV 331
Cdd:TIGR00900 235 PYVQSKYLGR-GSTHYGWVLAAFGLGALLGALLLGLLGRYFKRMALMTGAIFVIGLAILVVGLTPPnFPLFLVLWFAIGV 313
|
330 340 350
....*....|....*....|....*....|..
gi 446430331 332 GEMMYVPVRQSIMADMVPNEARGSYMAINGMV 363
Cdd:TIGR00900 314 GYGPINVPQGTLLQRRVPAELLGRVFGAQFSL 345
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
35-383 |
3.06e-08 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 55.27 E-value: 3.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 35 FSIKLGSAIAGALLLINVIASLViglyGGYVGDR-LGRKKVMIIGQSIQVISIACMGIANSdyvdSPWLTFIFMLVNSLG 113
Cdd:cd17346 37 FSEADAASIYGAYTALVYLTPII----GGWLADKvLGARRTVFIGGILMALGYLLLALSPF----SVSMLYLGLALIIVG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 114 SGLMNPATEAMLIDVSTP--ENRKVMYSINYWAINLSIAIGAIFGGLLFENYRLQLfiGLTVIAVITLYVMAVYmeeVYV 191
Cdd:cd17346 109 NGLFKPNISSLVGKLYDEndPRRDSGFSIFYMGINLGAFLAPLLCGTLGDNYGYHY--GFGLAAVGMLLGLLIF---LLG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 192 ARKIVEKKNVLkdmadsykvvmkdkAFLIFCAASICTLSLEFQInnylgvrlqkeFETVHFLFGNGVTFDLTGIRM-LSW 270
Cdd:cd17346 184 RKKLLERKKML--------------AIIILFLFAVVFWAIYEQA-----------GTSLALFADENVDRLLGGFTIpPSW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 271 ISAENTILVVLCSALLI----KMLKSFNDLKILY---VGLFIYTIGFTIL---------GTSNSLWILLIAGLFQTVGEM 334
Cdd:cd17346 239 FQSLNPLFIILLAPILAalwtKLGKRGKDPSIPTkfaLGLLLLGLSFLLMvlaasfaggSGKVSALWLVLSYFLQTLGEL 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 446430331 335 MYVPVRQSIMADMVPNEARGSYMainGMVFQVAKMNGALGVMLGSFIAS 383
Cdd:cd17346 319 CLSPVGLSMITKLAPAKFAGFMM---GLWFLASALGNILAGYLAGFYAQ 364
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
34-156 |
1.52e-07 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 53.43 E-value: 1.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 34 YFSIKLGSAIAGALLLINVIASLVIG-----LYGGYVGDRLGRKKVMIIGQSIQVISIACMGIANSDYvdSPWLTFIFML 108
Cdd:pfam00083 33 GLSKSVSSLAALSVLSGLIVSIFSVGcfigsLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKW--SVYQLIVGRV 110
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 446430331 109 VNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFG 156
Cdd:pfam00083 111 LVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFG 158
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
41-184 |
2.43e-07 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 52.83 E-value: 2.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 41 SAIAGALLLINVIASLVIGLY---GGYVGDRLGRKKVMIIGQSIQVISIACMGIANSDYVDSPWLTFIFMLVNSLGSGLM 117
Cdd:pfam05977 41 SASPLMVALVQAAATLPIFLLsipAGALADNFDRRKIMLAGQLLLALVSTLLTLLAGLGLLSPWLLLGLTFLGGIGTALM 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446430331 118 NPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLfenyrLQLFIGLTVIAVITLYVMAV 184
Cdd:pfam05977 121 DPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVL-----LAAFGPAFTFALNALSYFAV 182
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
63-402 |
5.54e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 51.42 E-value: 5.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 63 GYVGDRLGRKKVMIIGQSIQVI-SIACMgiansdYVDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSIN 141
Cdd:cd17320 55 GPLSDRFGRRPVLLAGLLLFILaSLLCA------LASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 142 YWAINLSIAIGAIFGGLL--FENYRLqLFIGLTVIAVITLYVMAVYMEEVYVARKIvekKNVLKDMADSYKVVMKDKAFL 219
Cdd:cd17320 129 MMILAIAPALAPLLGGLLllFFGWRA-IFVFLALLGLLLLLLVLLFLPETLPEEKR---KPLLSSLLRAYKRVLKNRRFL 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 220 IFCAASICTLSLEFQINNYLGVRLQKEFetvhflfgnGVTfdltgIRMLSWISAENTILVVLCSALLIKMLKSFNDLKIL 299
Cdd:cd17320 205 GYALALGLSFAGLFAYLAAAPFIYIEQL---------GLS-----PAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 300 YVGLFIYTIGF-----TILGTSNSLWILLIAGLFQTVGEMMYVPVRQSIMADMVPNEArGSYMAINGMVFQVAkmnGALG 374
Cdd:cd17320 271 RLGLLLLLAAAlvlllAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVA-GTASALLGFLQFLI---GALA 346
|
330 340 350
....*....|....*....|....*....|.
gi 446430331 375 VMLGSFIAS---WGMSALYFIVGMSSILLFM 402
Cdd:cd17320 347 GALVGLLPNgtaLPMGLLILVLGLLALLLLI 377
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
26-401 |
1.23e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 50.29 E-value: 1.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 26 MIFPFMAIYfsiklGSAIAGALLLINVIAslvIGLYG----------GYVGDRLGRKKVMIIGQSIQVISIACMGIANSd 95
Cdd:cd17472 14 LVLPVLSVY-----AKSLPGATPTLIGLA---LGIYGltqaifqipfGLLSDRIGRKPVILFGLLLFIAGSLLAAYATS- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 96 yvdspwltfIFMLVNS---LGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYRL-QLFIGL 171
Cdd:cd17472 85 ---------IYGLILGralQGSGAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVsGLFLIT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 172 TVIAVITLYVMAVYMEEVYVARKIVEKKNVlkdmadSYKVVMKDKAFLIFCAASICTLSLEFQINNYLGVRLQKEFETVH 251
Cdd:cd17472 156 AILSLVSLLILLFFVPDPPKIVQISEKEKK------KLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 252 FLFgngvtfdltgirmlsWISAENTILVVLCSALLIKMLKSFNDLK-ILYVGLFIYTIGFTILG-TSNSLWILLIAGLFQ 329
Cdd:cd17472 230 QLW---------------KVYLPAILIGFILMVPFVIYAEKKGKMKqVFVSSILLIAVGFLLLLfAATSLWLLIIGLIIF 294
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446430331 330 TVGEMMYVPVRQSIMADMVPNEARGSYMAI-NGMVFQVAKMNGALGvmlGSFIASWGMSALYFIVGMSSILLF 401
Cdd:cd17472 295 FIGFNLLEALLPSLVSKIAPKEYRGTAMGIyNTSQFLGSFLGGALG---GLLWGLLGYSSVFLTILILALLWL 364
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-182 |
2.05e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 49.49 E-value: 2.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 18 FLTRTVSTMIFPFMAIYFSIKLG--SAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIANsd 95
Cdd:COG2223 215 FGTFGSFIGFSSWLPPYLVDQFGlsAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAL-- 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 96 yvDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFE---NYR--LQLFIG 170
Cdd:COG2223 293 --GSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDatgSYTaaFLVFAV 370
|
170
....*....|..
gi 446430331 171 LTVIAVITLYVM 182
Cdd:COG2223 371 LALVALVLTLLL 382
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
27-227 |
2.12e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.48 E-value: 2.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 27 IFPFMAIYFSIKLgsAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIAnsdyvDSPWLTFIF 106
Cdd:cd17478 18 LLPLLIAKLGLSY--AQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFA-----PNYWLLLLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 107 MLVNSLGSGLMNPATEAMLIDVSTPENRKVMySINYWAINLSIAIGAIFGGLLFEnyrLQLFIGLTVIAVITLYVMAVYM 186
Cdd:cd17478 91 VALAGIGSAAFHPEGARLASQAAGGRRGLAM-SIFSVGGNLGFALGPLIAAALVA---LFGGLGLLILLIIPGLAVALLL 166
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 446430331 187 EEVYVARKIVEKKNVLKDMADSYKVVMKdKAFLIFCAASIC 227
Cdd:cd17478 167 LRLRPLKKPEAKKAAAKSSARSTLKGVW-RALLLLLIIVFL 206
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
14-167 |
2.24e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 49.48 E-value: 2.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 14 IITSFLTRTVSTMIFPFMAIYFSIKLG--SAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGI 91
Cdd:cd17321 174 VLAAFLLGAALGGLLFLLPLYLQGVLGysPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL 253
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446430331 92 ANSDyvDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIG-AIFGGLLFENYRLQL 167
Cdd:cd17321 254 LGAD--SSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGvALLGALLTAGLSANL 328
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
39-359 |
3.77e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 48.77 E-value: 3.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 39 LGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGqsIQVISIACMGIANSDYVdspWLTFIFMLVNSLGSGLMN 118
Cdd:cd17328 31 IDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVG--ILIWSAATLLSSFAPNF---WQLLLFRALVGIGEASYS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 119 PATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGL---LFENYRLQLFI--GLTVIAVITLYVMaVYMEEVYVAR 193
Cdd:cd17328 106 PIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLvaqATGGWRWAFRVtgVLGVLLAILLLLF-VREPPRGAAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 194 KIVEKKNVLKDMADSYKVVMKDKAFLI----FCAASICTLSLEFQINNYlgvrLQKEFETVHFLFGNgVTFDLTGIRMLS 269
Cdd:cd17328 185 GGVMAKSTATSFLADLKALAKNPSFILstlgFTAVSFVTGALAFWAPTF----FLRAFGVGDLSSAD-VGLIFGAITCIA 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 270 wisaenTILVVLCSALLIKMLKSFN---DLKILYVGLFI---YTIGFTILGTSNSLWILLIAGLFQTVGEMMYVPVRQSI 343
Cdd:cd17328 260 ------GVLGVLLGGILADRLRRKTpraDPLVCAVGLLAaapFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAIL 333
|
330
....*....|....*.
gi 446430331 344 MADMVPNeARGSYMAI 359
Cdd:cd17328 334 LYVVIPT-RRSTASAI 348
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
267-402 |
3.81e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.57 E-value: 3.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 267 MLSWISAENTILVVLCSALLIKMLKSFNDLKILYVGLFIYTIGFTILGTSNSLWILLIAGLFQTVGEMMYVPVRQSIMAD 346
Cdd:pfam07690 33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIAD 112
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446430331 347 MVPNEARGSYMAINGMVFQVAkmnGALGVMLGSFIAS-WGMSALYFIVGMSSILLFM 402
Cdd:pfam07690 113 WFPPEERGRALGLVSAGFGLG---AALGPLLGGLLASlFGWRAAFLILAILSLLAAV 166
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-188 |
4.63e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 48.33 E-value: 4.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 14 IITSFLTRTVSTMIFPFMAIYFSIKLG--SAIAGALLLINVIASLVIGLYGGYVGDRLGR--KKVMIIGQSIQVISIACM 89
Cdd:COG2271 186 ALAYFLVYFALYGFLTWLPTYLVEVRGlsLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLL 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 90 GiansdYVDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYRLQ--- 166
Cdd:COG2271 266 A-----LLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQaaf 340
|
170 180
....*....|....*....|...
gi 446430331 167 -LFIGLTVIAVITLYVMAVYMEE 188
Cdd:COG2271 341 lLLAALALLAALLALLLLRETRK 363
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
26-409 |
5.65e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 48.34 E-value: 5.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 26 MIFPFMAIYFSIKLG--SAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIqvISIACMGIAnsdYVDSPWLT 103
Cdd:COG2223 22 YLWSVLAPPLAEEFGlsAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL--LGIGLLLLA---LAVSYWLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 104 FIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYRLQL-FIGLTVIAVITLYVM 182
Cdd:COG2223 97 LLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNaFLILGILLLVVAVLA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 183 AVYMEEVYVARKIVEKKNVLkdmadSYKVVMKDKAFLIFCAASICTLSLEFQINNYLGVRLQKEFetvhflfgnGVTFDL 262
Cdd:COG2223 177 WLFLRDPPAGAAAAAKASLR-----DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQF---------GLSAAT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 263 TGIrMLSWISAENTILVVLCSALLIKMLKSfndlKILYVGLFIYTIGFTILG-TSNSLWILLIAGLFQTVGEMMYVPVRQ 341
Cdd:COG2223 243 AGL-LAALFALLGALGRPLGGWLSDRIGGR----RVLLIVFALMALGLLLLAlALGSLWLFLVLFLLLGLALGGGNGAVF 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446430331 342 SIMADMVPNEARGSYMAINGMVFQVA-----KMNGALGVMLGSFIASWGMSALYFIVGMSSILLFMKAIGREK 409
Cdd:COG2223 318 ALVPDIFPTKNAGAVYGLVGAAGGLGgflgpLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
15-184 |
2.44e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 46.03 E-value: 2.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 15 ITSFLTRTVSTMIFPFMAIYFSIKLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIANS 94
Cdd:cd17330 184 FLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASS 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 95 dyvdsPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYRLQL-FIGLTV 173
Cdd:cd17330 264 -----VPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVpFLLAAG 338
|
170
....*....|.
gi 446430331 174 IAVITLYVMAV 184
Cdd:cd17330 339 LLLIALFLLSL 349
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
17-247 |
5.00e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 45.31 E-value: 5.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 17 SFLTRTVSTMIfPFMAIYFSIKLGSA--IAGALLLINVIASLVIGlyggYVGDRLGRKKVMIIGQSIQVISIACMGIANs 94
Cdd:cd17475 9 SLVAQGIPALA-PFLQEDLHLSLAQVglLLSALNLGVAVSMLPAG----WLLDRFGERRVLAVGLLLMGAAALLMALVG- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 95 dyvdSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENYRLQL-FIGLTV 173
Cdd:cd17475 83 ----SYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAaFVVAGL 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446430331 174 IAVI-TLYVMAVYMEEVYVARKIVEKKNVLKdmadSYKVVMKDKAFLIFCAASICTLSLEFQINNYLGVRLQKEF 247
Cdd:cd17475 159 VSILaAVLFWLFYREPPAASAATESASTLLR----SLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHL 229
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
22-134 |
5.35e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 45.14 E-value: 5.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 22 TVSTMIFPfmaIYFS--IKLGSAIAGALLL--INVIASLVIGLYG---GYVGDRLGRKKVMIIGQS-IQVISIACMGIAN 93
Cdd:COG2270 28 VITTFVFP---PYFTsvAALGDPAAATALWgyALAIAGLLVALLApvlGAIADRSGRKKPFLAFFTlLGVLATAALFFVA 104
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 446430331 94 SDYVdspWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENR 134
Cdd:COG2270 105 PGGL---WLGLLLFVLANIGFEGSLVFYNAFLPDIATPEEI 142
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
52-400 |
7.77e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.46 E-value: 7.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 52 VIASLVIGLyggyVGDRLGRKKVMIIGQSIQVISIACMGIANSdyvdsPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTP 131
Cdd:cd17324 48 ALGALLLGP----LSDRIERRRLLLVLLLLFILGNLLAALAPS-----FALLLLARALAGLAHGGFWAIAAAYAADLVPP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 132 ENRKVMYSINYWAINLSIAIGAIFGGLLFE--NYRLqLFIGLTVIAVITLYVMAVYMeevyvaRKIVEKKNVLKDMADSY 209
Cdd:cd17324 119 EKRGRAIGLVFSGLTLGLVLGRPLGGLLGQllGWRA-AFLAIAVLALLAALLLWRLL------PSLPPKKPGSLGLLSSL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 210 KVVMKDKAFLIFCAASICTLSLEFQINNYLGVRLQKEFET-------VHFLFG-NGVTFDLTGIRMLSWISAENTILV-V 280
Cdd:cd17324 192 LLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFsssaiigLLLLFGvAGVVGSPLAGRLADRGGRRALLIAlL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 281 LCSALLIKMLKSFNDLKILYVGLFIYTIGFTILGTSNSLWILLIAGlfqtvgemmyvpvrqsimadmvpnEARGSYMAIN 360
Cdd:cd17324 272 LLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP------------------------EARGLASSLY 327
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 446430331 361 GMVFQVAkmnGALGVMLGSFIASWGMSALYFIVGMSSILL 400
Cdd:cd17324 328 LAAYNLG---GALGAALGGLVLDHGGWAGVGWVGAALLLL 364
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
297-384 |
7.85e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.49 E-value: 7.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 297 KILYVGLFIYTIGFTILGTSNSLWILLIAGLFQTVGEMMYVPVRQSIMADMVPNEARGSYMAINGMVFQVAKmngALGVM 376
Cdd:cd17503 62 RLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAP---AIGPT 138
|
....*...
gi 446430331 377 LGSFIASW 384
Cdd:cd17503 139 LGGWLTDN 146
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
3-157 |
1.17e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 44.05 E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 3 FWSMHRNIKIRIITSFLTRTVSTMIFPFMAIYFSIKLG---SAIAGALLLINVIASLVIGLYGgYVGDRLGRKKVMIIGQ 79
Cdd:cd17369 223 LRRHWRALLLAIGLRLAENVLFYLFTTFALSYATQTLGvdrSTVLLAVLIASVVAAITIPLFG-WLSDRVGRRPVYLAGA 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 80 SIQVISI--ACMGIANSdyvDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRkvmysinYWAINLSIAIGAIFGG 157
Cdd:cd17369 302 LLAALFAfpFFWLLDTG---STWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVR-------YTGASLGYQLGAILGG 371
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
276-401 |
2.01e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 43.31 E-value: 2.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 276 TILVVLCSALLIKMLKSFNDLKILYVGLFIYTIGFTILGTSNSLWILLIAGLFQTVGEMMYVPVRQSIMADMVPNEARGS 355
Cdd:cd17324 44 ALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGR 123
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 446430331 356 YMAINGMVFQVAkmnGALGVMLGSFIAS-WGMSALYFIVGMSSILLF 401
Cdd:cd17324 124 AIGLVFSGLTLG---LVLGRPLGGLLGQlLGWRAAFLAIAVLALLAA 167
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
7-170 |
2.18e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.95 E-value: 2.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 7 HRNIKIRIITSFLTRTVSTMIFPFMAIYFS------IKLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQS 80
Cdd:cd17504 176 RRNVLLANITALLAGFGMFMVFQLLPQLLQlptptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLV 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 81 IQVISIACMGIansdYVDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLF 160
Cdd:cd17504 256 ISAVGLLLLAL----LHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIL 331
|
170
....*....|
gi 446430331 161 ENYRLQLFIG 170
Cdd:cd17504 332 TTYTVSITSG 341
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-153 |
2.60e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.79 E-value: 2.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 14 IITSFLTRTVSTMIFPFMAIYFSIK-LGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIA 92
Cdd:pfam07690 206 LLALLLFGFAFFGLLTYLPLYQEVLgLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLL 285
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446430331 93 NSdyVDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGA 153
Cdd:pfam07690 286 SL--TLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
14-163 |
2.61e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 42.98 E-value: 2.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 14 IITSFLTRTVSTMIFPFMAIYFS-IKLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIA 92
Cdd:cd17332 227 LLAYLLYFLAFNIVNTVLVYYFKyVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFL 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446430331 93 nsdYVDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRK-------VMYSINYWAINLSIAIGAIFGGLLFENY 163
Cdd:cd17332 307 ---PPGNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGELKtgkrregIFYSVMTFFRKLGLALAGALVGLILSLA 381
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
35-188 |
2.94e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 42.56 E-value: 2.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 35 FSIKLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIANSDYVdspwltFIFM-LVNSLG 113
Cdd:cd17315 27 LGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV------LIVGrFLLGLG 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446430331 114 SGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENY--RLQLFIGLTVIAVITLYVMAVYMEE 188
Cdd:cd17315 101 VGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPpgWWRLMFALAAVPALLQLLLMFFLPE 177
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
17-188 |
3.46e-04 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 42.75 E-value: 3.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 17 SFLTRTVSTMIFPFMAIYFSIKLGSAIAGALLLINVIASLVIGLYGgyvgDRLGRKKVMIIGQSIQVISIACMGIANSdY 96
Cdd:cd17368 19 GFFAVYIGRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYA----DRIGRKPAMTLTLAIMALGTLLIALAPT-Y 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 97 ----VDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFE----------N 162
Cdd:cd17368 94 atigIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSLtltaealaewG 173
|
170 180
....*....|....*....|....*.
gi 446430331 163 YRLQLFIGLTVIAVItlYVMAVYMEE 188
Cdd:cd17368 174 WRIPFFIGLLIIPLG--LWLRRSLEE 197
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
27-402 |
3.49e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 42.57 E-value: 3.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 27 IFPFMAIYF-SIKLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIgqsiqvISIACMGIANSDY---VDSPWL 102
Cdd:cd17335 16 LLPFLSVYLkQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLL------LSLLAAVLFFLSLffvAQIFWL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 103 TFIFMLVNSLGSGLMNPATEAMLIDvSTPENRKvmysiNYWAINL--SIA--IGAIFGGLLFENYRLQ-----LFIGLTV 173
Cdd:cd17335 90 LLLLVILGAFFSAPVVPLVDSITLQ-YLGEERE-----RYGKQRLwgSIGfgIAALLVGILIDRSSTYknytiAFYVFAV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 174 IAVITLYVMAVYMEEVYVARKIVEKKNVLKdmadsykvVMKDKAFLIF-CAASICTLSLEFqINNYLGVRLQkefetvhf 252
Cdd:cd17335 164 LMLLALLLALKFPFRPKHPEPNENTGGLLA--------LLRNPRVLAFlLVAFLMGFGHGL-IYSFLFWHLQ-------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 253 lfgngvtfDLTGIRML-SWISAENTILVVLCSALLIKMLKSFNDLKILYVGLFIYTIGFTILGTSNSLWILLIAGLFQ-- 329
Cdd:cd17335 227 --------DLGGSKTLiGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHgl 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446430331 330 TVGEMMYVPVrqSIMADMVPNEARGSYMAINGMVFqvAKMNGALGVML-GSFIASWGMSALYFIVGMSSILLFM 402
Cdd:cd17335 299 TFALVWAAAV--SYASAAAPPGLRATAQGLLQGLY--FGLGGGLGSLIgGYLYEAFGARTTFRFFAIAALAGLL 368
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
14-179 |
3.77e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.16 E-value: 3.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 14 IITSFLTRTVSTMIFPFMAIYFSIK-LGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGia 92
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLEREgVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 93 nsdYVDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGlLFENYRLQLFIGLT 172
Cdd:cd17477 80 ---LTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLA-LVGTAGALPFLIAA 155
|
....*..
gi 446430331 173 VIAVITL 179
Cdd:cd17477 156 VLLLLAL 162
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
15-157 |
4.30e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 42.25 E-value: 4.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 15 ITSFLTRTVSTMIFPFMAIYFSIKLGSA-----IAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQ---SIQVISI 86
Cdd:cd17391 208 VTTFIIQLANQSIEPILTLYIRQLMGDAsnlafISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALlasALLYIPQ 287
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446430331 87 AcmgiansdYVDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGG 157
Cdd:cd17391 288 A--------FVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGS 350
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
5-384 |
4.30e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 42.34 E-value: 4.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 5 SMHRNIKIRIITSFLTRTVS---TMIFPFMA--IYFSIKLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIgq 79
Cdd:TIGR00895 10 PLSRYQWRAIILSFLIMLMDgydLAAMGFAApaISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLW-- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 80 SIQVISIACMGIANSDYVDSpwlTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLL 159
Cdd:TIGR00895 88 SILLFSVFTLLCALATNVTQ---LLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 160 FENYRLQ-LFIGLTVIAVITLYVMAVYMEEVY---VARKIVEKKNVLKDMADSY------------------KVVMK--- 214
Cdd:TIGR00895 165 IPVFGWRsLFYVGGIAPLLLLLLLMRFLPESIdflVSKRPETVRRIVNAIAPQMqaeaqsalpeqkstqgtkRSVFKalf 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 215 ----DKAFLIFCAASICTLSLEFQINNYLGVrlqkefetvhFLFGNGVTFDLTGIRMLSwISAENTILVVLCSALLIKML 290
Cdd:TIGR00895 245 qgktARITVLLWLLYFMLLVGVYFLTNWLPK----------LMVELGFSLSLAATGGAL-FNFGGVIGSIIFGWLADRLG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 291 KSFNDLKILYVGLFIYTIGFTILGTSNSLWILLIAGLFQTVGEMMYVpvrqSIMADMVPNEARGSymAINGMVfqvakMN 370
Cdd:TIGR00895 314 PRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLY----ALMALFYPTAIRAT--GVGWAI-----GI 382
|
410
....*....|....
gi 446430331 371 GALGVMLGSFIASW 384
Cdd:TIGR00895 383 GRLGAIIGPILAGY 396
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
297-401 |
5.05e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.83 E-value: 5.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 297 KILYVGLFIYTIGFTILGTSNSLWILLIAGLFQTVGEMMYVPVRQSIMADMVPNEARGSYMAINGMVFQVAkmnGALGVM 376
Cdd:cd17329 66 PVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLG---VAIGPL 142
|
90 100
....*....|....*....|....*
gi 446430331 377 LGSFIASWGMSALYFIVGMSSILLF 401
Cdd:cd17329 143 LGGLLLLYSFRLLFLAAAVLFLLAA 167
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
8-155 |
5.22e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 41.78 E-value: 5.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 8 RNIKIRIITSFLTRTVSTMIFPFMAIYF-SIKLGSAIAGALLLINVIASLVIGLY-GGYVGDRLGR-KKVMIIGQSIQVI 84
Cdd:cd17502 167 RTILLSSIFGFLFGGALFGLIYYLPLYFqLVLGDSATKSGVRLLPLIIGLVIGSIiSGALISKTGRyKPLIVIGTILMSV 246
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446430331 85 SIACMgiANSDYVDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIF 155
Cdd:cd17502 247 GAGLL--TTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
297-401 |
5.96e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.79 E-value: 5.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 297 KILYVGLFIYTIGFTILGTSNSLWILLIAGLFQTVGEMMYVPVRQSIMADMVPNEARGSYMAINGMVFQVAKmngALGVM 376
Cdd:cd17474 65 KVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGI---AVGPL 141
|
90 100
....*....|....*....|....*
gi 446430331 377 LGSFIASWGMSALYFIVGMSSILLF 401
Cdd:cd17474 142 LGGLLAAISWRYPFFLLAALIPVAF 166
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
27-181 |
1.30e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.66 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 27 IFPFMAIYFSIKLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACMGIAnsdyvDSPWLTFIF 106
Cdd:cd17316 21 VAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL-----PTPILLLVL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 107 MLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLL------FENYRLQLFIGLtVIAVITLY 180
Cdd:cd17316 96 RFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllsgDWGWRILFLIGA-LPALLALL 174
|
.
gi 446430331 181 V 181
Cdd:cd17316 175 L 175
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
297-400 |
1.37e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 40.62 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 297 KILYVGLFIYTIGFTILGTSNSLWILLIAGLFQTVGEMMYVPVRQSIMADMVPNEARGSYMAINGMVFQVAkmNGALGVM 376
Cdd:COG2271 76 RVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLG--GALAPPL 153
|
90 100
....*....|....*....|....
gi 446430331 377 LGSFIASWGMSALYFIVGMSSILL 400
Cdd:COG2271 154 LGWLLAAFGWRAAFLILGLPGLLL 177
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
63-379 |
1.80e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 40.25 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 63 GYVGDRLGRKKVMIIGQSIQVISIACMGIANSdyvdSPWLTfIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINY 142
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPN----LASLI-IFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 143 WAINLSIAIGAIFGGLLFENYRLQ-LFIGLTVIAVITLYVMAVYmeevyvarkivekknvlkDMAdsykvVMKDKAFLIF 221
Cdd:cd17503 127 LVILLAPAIGPTLGGWLTDNLSWRwIFYINLPIGILALLLAPLL------------------DLR-----LFKDRNFTLG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 222 CAAS----ICTLSLEFQINNYLGVRLqkefetvhflfgnGVTFDLTGIRMLSWIsaentILVVLCSALLIKMLKSFNDLK 297
Cdd:cd17503 184 LLLSfllgLGLFGAMFLLPLYLQNVL-------------GYSAFESGLVLAPGG-----LASAILSPLVGRLLDKFGPRL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 298 ILYVGLFIYTIG---FTILGTSNSLWILLIAGLFQTVGEMM-YVPVRQSIMADmVPNEARGSYMAINGMVFQVAkmnGAL 373
Cdd:cd17503 246 LLLAGLLLLALGtllLAFLTPDTSLWLIILPLFIRGLGMGLvFMPLNTLALNS-LPPEQIGDATALFNTIRQLG---GSI 321
|
....*.
gi 446430331 374 GVMLGS 379
Cdd:cd17503 322 GTALLA 327
|
|
| MFS_FBT |
cd17484 |
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ... |
28-240 |
2.29e-03 |
|
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 39.90 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 28 FPFMAIYFSIK----LGSAIAGALLLINVIASLVIGLYGgYVGDRLG-----RKKVMIIGQSIQVISIACMGIANSDyvd 98
Cdd:cd17484 15 LSWLAVSYYYKddlhLGPASVQALTSIASLPWAIKPLYG-LLSDSVPifgyrRKPYLILAGALGALSWLALALVSNS--- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 99 SPWLTFIFMLVNSLGSGLMNPATEAMLIDVStpenRKVMYSINYWAINL---SIAIGAI----FGGLLFENYRLQLFIGL 171
Cdd:cd17484 91 SLALALLLLLLASLGVAFSDVVIDALVVEAS----RGAPQSLAGDLQSLcwgSSAIGGIvgsyFSGYLLELLGPRTVFAV 166
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446430331 172 TVIAVITLYVMA--VYMEEVYVARKIVEKKNVLKDM--ADSYKVVMKDKAF-LIFCAASICTLSLEFQINNYLG 240
Cdd:cd17484 167 TSFFPLLLLIVAffVKEERVPPHRTKENFDEQLKALweTVKQPSIWLPALFiFLYQATPSSGSAMFYFMTNELG 240
|
|
| PRK10054 |
PRK10054 |
efflux MFS transporter YdeE; |
29-405 |
3.21e-03 |
|
efflux MFS transporter YdeE;
Pssm-ID: 182213 Cd Length: 395 Bit Score: 39.34 E-value: 3.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 29 PFMAIYFS--IKLGSAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGqsiqvISIACMGIANSDYVDSPWLTFIF 106
Cdd:PRK10054 28 PFMTIYLSrqYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLA-----ITAFASGFIAIPLVNNVTLVVLF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 107 MLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFEnYRLQLFIGLTVI-AVITLYVMAVY 185
Cdd:PRK10054 103 FALINCAYSVFSTVLKAWFADNLSSTSKTKIFSLNYTMLNIGWTVGPPLGTLLVM-QSINLPFWLAAIcSAFPLVFIQIW 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 186 MEEVYVArkIVEKKNVlkdmADSYKVVMKDKAFLIFCA----ASICTLSLEFQINNYLGVRLQKEFETvhflfgngvtfd 261
Cdd:PRK10054 182 VQRSEKA--IATETGS----VWSPSVLLQDKALLWFTCsgflASFVSGAFASCISQYVMVVADSDFAE------------ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 262 ltgiRMLSWISAENTILVVLCSALLIKMLKSFNDLKILYVGLFIYTI---GFTILGtsNSLWILLIAGLFQTVGEMMYVP 338
Cdd:PRK10054 244 ----KVVAVVLPVNAAMVVSLQYSVGRRLNAANIRPLMTAGTLCFVIglvGFIFSG--NSLLLWGMSAAVFTVGEIIYAP 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446430331 339 VRQSIMADMVPNEARGSYMAINGMVFQVAKMNGALGVMLGSFIASWGMSALYFIVGMSSILLFMKAI 405
Cdd:PRK10054 318 GEYMLIDHIAPPGMKASYFSAQSLGWLGAAINPLVSGVILTTLPPWSLFVILALAIVAAWLLMLKGM 384
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
297-384 |
3.22e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.41 E-value: 3.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 297 KILYVGLFIYTIGFTILGTSNSLWILLIAGLFQTVGEMMYVPVRQSIMADMVPNEARGSYMAINGMVFQVAkmnGALGVM 376
Cdd:COG0477 80 RVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLG---LALGPL 156
|
....*...
gi 446430331 377 LGSFIASW 384
Cdd:COG0477 157 LGGLLVAA 164
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
41-188 |
3.92e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 39.17 E-value: 3.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 41 SAIAGALLLINVIASLVIGLyggyVGDRLGRKKVMIIGQSIQVISIACMGIANSDYvdSPWLTFIFMLVNSLGSGLMNPA 120
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAF----LANRFGRKNGLLISNALLVVSSLLMFLSKSAK--SPELLIFGRFLVGIACGLSTGF 125
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 121 TEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFG--GLLFENYRLQLFIGLTVIAVITLYVMAVYMEE 188
Cdd:cd17357 126 VPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFGlpSVLGTETLWPYLLFFPGIPALLQLAALPFFPE 195
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
6-183 |
4.45e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.12 E-value: 4.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 6 MHRNIKIRIITSFLTRTVSTMIFPFMAIYFSIKLG--SAIAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQV 83
Cdd:cd17316 175 LRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGlsPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 84 ISIACMGIANSdyvDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENY 163
Cdd:cd17316 255 ILALPLFYLLS---GSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAST 331
|
170 180
....*....|....*....|
gi 446430331 164 RLQLFIGLTVIAVITLYVMA 183
Cdd:cd17316 332 GGTGVPALILALLAIVALIV 351
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
7-160 |
4.71e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.98 E-value: 4.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 7 HRNIKIRIITSFLTRTVSTMIFPFMAIYFSIKLG---SAIAGALLLINVIAsLVIGLYGGYVGDRLGRKKVMIIgqSIQV 83
Cdd:COG2270 237 YRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGfstTELIVFGLLVQIVA-ALGALLFGRLDDRIGPKRVILV--SLVI 313
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446430331 84 ISIACMGIAnsdYVDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSInYwaiNLSIAIGAIFGGLLF 160
Cdd:COG2270 314 WIVVCLAAY---FLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGL-Y---ALSGKAASFLGPLLF 383
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
41-195 |
4.79e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 39.52 E-value: 4.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 41 SAIAGALLLINVIaslVIGLYGGYVGDRLGRKKVMIIGQSIQVIsIACMGIAnSDYVDSPWLTFIFMLVNSLGSGLMNPA 120
Cdd:PRK08633 49 TAIVNALFLLPFL---LLSSPAGFLADKFSKNRVIRIVKLFEVG-LTLLIVL-AYYLGWFWLAFAVTFLLGAQSAIYSPA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 121 TEAMLIDVSTPEN----RKVMYSINYwainLSIAIGAIFGGLLFEN-YRLQLFIGLTVIAVITLYVMAVYMEEVYVARKI 195
Cdd:PRK08633 124 KYGIIPELVGKENlsraNGLLEAFTI----VAILAGTALFSFLFESvNGNTPSEILGRIAPAGLVLLAVAVLGLIFAYRL 199
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
15-163 |
5.02e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 38.75 E-value: 5.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446430331 15 ITSFLTRTVSTMIFPFMAIYFSIKLGSA-----IAGALLLINVIASLVIGLYGGYVGDRLGRKKVMIIGQSIQVISIACM 89
Cdd:PRK09874 226 VTTLIIQVATGSIAPILTLYVRELAGNVsniafISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPM 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446430331 90 giansDYVDSPWLTFIFMLVNSLGSGLMNPATEAMLIDVSTPENRKVMYSINYWAINLSIAIGAIFGGLLFENY 163
Cdd:PRK09874 306 -----SFVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANY 374
|
|
| |
