NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446436433|ref|WP_000514288|]
View 

MULTISPECIES: TrkA family potassium uptake protein [Staphylococcus]

Protein Classification

potassium channel family protein( domain architecture ID 11426271)

potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium translocate across cell membranes, similar to Trk system potassium uptake protein TrkA

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
3-202 2.69e-57

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 183.34  E-value: 2.69e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446436433   3 KEYVVIGLGRFGGSIVRELNALDMDVMAIDHDENRVNEYSDIATHAVVADTTDEAVMKSLGIRNFDHVIVAIGeNIQSST 82
Cdd:COG0569   96 MHVIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVLEEAGIEDADAVIAATG-DDEANI 174
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446436433  83 LTTLILKELGVKKVTAKAQNDYHAKILNKIGADTVVHPERDMGRRIAHNVASASVLDYLELAD-EHSIVELKATE--KMA 159
Cdd:COG0569  175 LACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELADgDAEIVEVTVPEgsPLV 254
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446436433 160 GKSIIDLDIRAQYGINIIAIKRGKEFIIsPNPNINLEIGDILI 202
Cdd:COG0569  255 GKTLKELDLRERYGVTVVAIKRGGEVII-PSGDTVLEAGDELI 296
 
Name Accession Description Interval E-value
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
3-202 2.69e-57

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 183.34  E-value: 2.69e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446436433   3 KEYVVIGLGRFGGSIVRELNALDMDVMAIDHDENRVNEYSDIATHAVVADTTDEAVMKSLGIRNFDHVIVAIGeNIQSST 82
Cdd:COG0569   96 MHVIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVLEEAGIEDADAVIAATG-DDEANI 174
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446436433  83 LTTLILKELGVKKVTAKAQNDYHAKILNKIGADTVVHPERDMGRRIAHNVASASVLDYLELAD-EHSIVELKATE--KMA 159
Cdd:COG0569  175 LACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELADgDAEIVEVTVPEgsPLV 254
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446436433 160 GKSIIDLDIRAQYGINIIAIKRGKEFIIsPNPNINLEIGDILI 202
Cdd:COG0569  255 GKTLKELDLRERYGVTVVAIKRGGEVII-PSGDTVLEAGDELI 296
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
5-120 1.10e-29

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 106.46  E-value: 1.10e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446436433    5 YVVIGLGRFGGSIVRELNAlDMDVMAIDHDENRVNEYSDIATHAVVADTTDEAVMKSLGIRNFDHVIVAIGENiQSSTLT 84
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELSE-GGDVVVIDKDEERVEELREEGVPVVVGDATDEEVLEEAGIEEADAVIAATGDD-EANILI 78
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 446436433   85 TLILKEL-GVKKVTAKAQNDYHAKILNKIGADTVVHP 120
Cdd:pfam02254  79 VLLARELnPDKKIIARANDPEHAELLRRLGADHVISP 115
trkA PRK09496
Trk system potassium transporter TrkA;
6-204 4.20e-14

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 70.15  E-value: 4.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446436433   6 VVIGLGRFGGSIVRELNALDMDVMAIDHDENRVNEYSDIATHAVV--ADTTDEAVMKSLGIRNFDhVIVAIGENIQSSTL 83
Cdd:PRK09496 235 MIVGGGNIGYYLAKLLEKEGYSVKLIERDPERAEELAEELPNTLVlhGDGTDQELLEEEGIDEAD-AFIALTNDDEANIL 313
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446436433  84 TTLILKELGVKKVTAKAQNDYHAKILNKIGADTVVHPERDMGRRIAHNVASASVLDYLELADEHS-IVELKATE--KMAG 160
Cdd:PRK09496 314 SSLLAKRLGAKKVIALVNRPAYVDLVEGLGIDIAISPRQATASEILRHVRRGDIVAVHSLRRGAAeAIEAVAHEtsKVVG 393
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 446436433 161 KSIIDLDIRAqyGINIIAIKRGKEFIIsPNPNINLEIGDILIMI 204
Cdd:PRK09496 394 KPLKDLKLPK--GVLIGAIVRGGEVII-PTGDTVIEPGDHVIVF 434
 
Name Accession Description Interval E-value
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
3-202 2.69e-57

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 183.34  E-value: 2.69e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446436433   3 KEYVVIGLGRFGGSIVRELNALDMDVMAIDHDENRVNEYSDIATHAVVADTTDEAVMKSLGIRNFDHVIVAIGeNIQSST 82
Cdd:COG0569   96 MHVIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVLEEAGIEDADAVIAATG-DDEANI 174
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446436433  83 LTTLILKELGVKKVTAKAQNDYHAKILNKIGADTVVHPERDMGRRIAHNVASASVLDYLELAD-EHSIVELKATE--KMA 159
Cdd:COG0569  175 LACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELADgDAEIVEVTVPEgsPLV 254
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 446436433 160 GKSIIDLDIRAQYGINIIAIKRGKEFIIsPNPNINLEIGDILI 202
Cdd:COG0569  255 GKTLKELDLRERYGVTVVAIKRGGEVII-PSGDTVLEAGDELI 296
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
5-120 1.10e-29

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 106.46  E-value: 1.10e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446436433    5 YVVIGLGRFGGSIVRELNAlDMDVMAIDHDENRVNEYSDIATHAVVADTTDEAVMKSLGIRNFDHVIVAIGENiQSSTLT 84
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELSE-GGDVVVIDKDEERVEELREEGVPVVVGDATDEEVLEEAGIEEADAVIAATGDD-EANILI 78
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 446436433   85 TLILKEL-GVKKVTAKAQNDYHAKILNKIGADTVVHP 120
Cdd:pfam02254  79 VLLARELnPDKKIIARANDPEHAELLRRLGADHVISP 115
Kch COG1226
Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];
6-147 3.81e-15

Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];


Pssm-ID: 440839 [Multi-domain]  Cd Length: 279  Bit Score: 72.07  E-value: 3.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446436433   6 VVIGLGRFGGSIVRELNALDMDVMAIDHDENRVNEYSDIATHAVVADTTDEAVMKSLGIRNFDHVIVAIGeNIQSSTLTT 85
Cdd:COG1226  128 IIAGFGRVGQIVARLLRAEGIPFVVIDLDPERVEELRRFGIKVYYGDATRPDVLEAAGIERARALVVAID-DPEAALRIV 206
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446436433  86 LILKELGVK-KVTAKAQNDYHAKILNKIGADTVVHPERDMGRRIAhnvasASVLDYLELADEH 147
Cdd:COG1226  207 ELARELNPDlKIIARARDREHAEELRQAGADEVVRETFESALQLA-----RHALEALGVPEEE 264
trkA PRK09496
Trk system potassium transporter TrkA;
6-204 4.20e-14

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 70.15  E-value: 4.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446436433   6 VVIGLGRFGGSIVRELNALDMDVMAIDHDENRVNEYSDIATHAVV--ADTTDEAVMKSLGIRNFDhVIVAIGENIQSSTL 83
Cdd:PRK09496 235 MIVGGGNIGYYLAKLLEKEGYSVKLIERDPERAEELAEELPNTLVlhGDGTDQELLEEEGIDEAD-AFIALTNDDEANIL 313
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446436433  84 TTLILKELGVKKVTAKAQNDYHAKILNKIGADTVVHPERDMGRRIAHNVASASVLDYLELADEHS-IVELKATE--KMAG 160
Cdd:PRK09496 314 SSLLAKRLGAKKVIALVNRPAYVDLVEGLGIDIAISPRQATASEILRHVRRGDIVAVHSLRRGAAeAIEAVAHEtsKVVG 393
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 446436433 161 KSIIDLDIRAqyGINIIAIKRGKEFIIsPNPNINLEIGDILIMI 204
Cdd:PRK09496 394 KPLKDLKLPK--GVLIGAIVRGGEVII-PTGDTVIEPGDHVIVF 434
trkA PRK09496
Trk system potassium transporter TrkA;
6-215 8.17e-14

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 69.38  E-value: 8.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446436433   6 VVIGLGRFGGSIVRELNALDMDVMAIDHDENRVNEYS---DIAThaVVADTTDEAVMKSLGIRNFDhVIVAIGENIQSST 82
Cdd:PRK09496   4 IIVGAGQVGYTLAENLSGENNDVTVIDTDEERLRRLQdrlDVRT--VVGNGSSPDVLREAGAEDAD-LLIAVTDSDETNM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446436433  83 LTTLILKEL-GVKKVTAKAQN-DY--HAKILNK--IGADTVVHPERDMGRRIAHNVASASVLDYLELADEH-SIVELKAT 155
Cdd:PRK09496  81 VACQIAKSLfGAPTTIARVRNpEYaeYDKLFSKeaLGIDLLISPELLVAREIARLIEYPGALDVEEFADGRvQLVEVKVY 160
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446436433 156 E--KMAGKSIIDLD-IRAQYGINIIAIKRGKEFIIsPNPNINLEIGDILIMIGHDNDLNRFEK 215
Cdd:PRK09496 161 EgsPLVGKPLSDLReHFPDIDVRVVAIFRGGRLII-PRGDTVIEAGDEVYFIGAREHIRAVMS 222
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
124-215 1.48e-13

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 65.33  E-value: 1.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446436433 124 MGRRIAHNVASASVLDYLELADEHSI---VELKATEKMAGKSIIDLDIRAQYGINIIAIKRGKEFIISPNPNINLEIGDI 200
Cdd:COG0490   44 ALLLLLLGELLRLLTRLLIELVLLLAieeVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDT 123
                         90
                 ....*....|....*
gi 446436433 201 LIMIGHDNDLNRFEK 215
Cdd:COG0490  124 LVVVGTREQLERLEE 138
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
149-217 1.55e-12

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 60.70  E-value: 1.55e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446436433  149 IVELKATEKMAGKSIIDLDIRAQYGINIIAIKRGKEFIIsPNPNINLEIGDILIMIGHDNDLNRFEKNI 217
Cdd:pfam02080   3 EVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLII-PSGDTVLEAGDRLLVIGTPDDLAALRELL 70
COG3273 COG3273
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
139-215 1.06e-09

Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];


Pssm-ID: 442504 [Multi-domain]  Cd Length: 387  Bit Score: 57.37  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446436433 139 DYLELADEHS---IVELKATEK--MAGKSIIDLDIRAQYGINIIAIKRGKEFIISPNPNINLEIGDILIMIGHDNDLNRF 213
Cdd:COG3273  302 PVVAEAVRESderIVRVTVPPGspLVGKTLGELKLETETGVRVIAIRRGGGWIYDPDGDTRLRAGDVLIVKGTREGLERL 381

                 ..
gi 446436433 214 EK 215
Cdd:COG3273  382 EE 383
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
156-215 3.86e-07

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 49.74  E-value: 3.86e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446436433 156 EKMAGKSIIDLDIRAQYGINIIAIKR-GKEFIisPNPNINLEIGDILIMIGHDNDLNRFEK 215
Cdd:COG2985  296 KEVAGKTLGELNLRNRFGVVITRVRRgGVELP--ATPDTVLQLGDRLTVVGPKEDVERVAK 354
PRK05326 PRK05326
potassium/proton antiporter;
138-215 4.75e-06

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 46.73  E-value: 4.75e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446436433 138 LDYLELAD-EHSIVELKATEKMAGKSIIDLDIRAqyGINIIAIKRGKEFIIsPNPNINLEIGDILIMIGHDNDLNRFEK 215
Cdd:PRK05326 406 LDPLEESDaELLEYRVPAGSWLVGKALRDLRLPR--GALIALIIRDGKLLV-PTGSTRLKAGDVLLVLGPERDLPALER 481
PRK03818 PRK03818
putative transporter; Validated
156-215 1.27e-05

putative transporter; Validated


Pssm-ID: 179654 [Multi-domain]  Cd Length: 552  Bit Score: 45.24  E-value: 1.27e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446436433 156 EKMAGKSIIDLDIRAQYGINIIAIKR-GKEFIisPNPNINLEIGDILIMIGHDNDLNRFEK 215
Cdd:PRK03818 299 EKVLGKKLRDLHLKNKYGVVISRLNRaGVELV--ASPDLSLQFGDILNLVGRPEAIDAVAN 357
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
156-217 1.44e-04

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 42.03  E-value: 1.44e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446436433 156 EKMAGKSIIDLDIRAQYGINIIAIKRGKEfIISPNPNINLEIGDILIMIGHDNDLNRFEKNI 217
Cdd:COG2985  212 PNLVGKTVAELEALLGTRVVISRIRRGGE-IIVPTPDTVLQEGDIVLVVGTREALEAAEALL 272
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH