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Conserved domains on  [gi|446438696|ref|WP_000516551|]
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DNA cytosine methyltransferase [Streptococcus pneumoniae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Dcm super family cl43082
DNA-cytosine methylase [Replication, recombination and repair];
1-51 5.25e-17

DNA-cytosine methylase [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG0270:

Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 70.99  E-value: 5.25e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446438696   1 MGKIVAIDLFSGAGGTTSGLKKSGIDVQVAVEIDSVAVKTYKLNNPEVSVI 51
Cdd:COG0270    1 SKKLTVIDLFAGAGGLSLGFEKAGFEVVFAVEIDPDACETYRANFPEAKVI 51
 
Name Accession Description Interval E-value
Dcm COG0270
DNA-cytosine methylase [Replication, recombination and repair];
1-51 5.25e-17

DNA-cytosine methylase [Replication, recombination and repair];


Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 70.99  E-value: 5.25e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446438696   1 MGKIVAIDLFSGAGGTTSGLKKSGIDVQVAVEIDSVAVKTYKLNNPEVSVI 51
Cdd:COG0270    1 SKKLTVIDLFAGAGGLSLGFEKAGFEVVFAVEIDPDACETYRANFPEAKVI 51
Cyt_C5_DNA_methylase cd00315
Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many ...
 7-51 6.96e-12

Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.


Pssm-ID: 238192 [Multi-domain]  Cd Length: 275  Bit Score: 57.24  E-value: 6.96e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 446438696   7 IDLFSGAGGTTSGLKKSGIDVQVAVEIDSVAVKTYKLNNPEVSVI 51
Cdd:cd00315    4 IDLFAGIGGFRLGLEKAGFEIVAANEIDKSAAETYEANFPNKLIE 48
DNA_methylase pfam00145
C-5 cytosine-specific DNA methylase;
7-52 7.35e-11

C-5 cytosine-specific DNA methylase;


Pssm-ID: 395093 [Multi-domain]  Cd Length: 324  Bit Score: 54.63  E-value: 7.35e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 446438696    7 IDLFSGAGGTTSGLKKSGIDVQVAVEIDSVAVKTYKLNNPEVSVID 52
Cdd:pfam00145   4 IDLFAGIGGFRLGLEQAGFECVAANEIDKSAAKTYEANFPKVPIGD 49
dcm TIGR00675
DNA-methyltransferase (dcm); All proteins in this family for which functions are known are ...
 7-47 1.47e-07

DNA-methyltransferase (dcm); All proteins in this family for which functions are known are DNA-cytosine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273211 [Multi-domain]  Cd Length: 315  Bit Score: 45.40  E-value: 1.47e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 446438696    7 IDLFSGAGGTTSGLKKSGIDVQVAVEIDSVAVKTYKLNNPE 47
Cdd:TIGR00675   2 IDLFAGIGGIRLGFEQAGFKCVFASEIDKYAQKTYEANFGN 42
PRK10458 PRK10458
DNA cytosine methylase; Provisional
 7-44 9.14e-03

DNA cytosine methylase; Provisional


Pssm-ID: 236696 [Multi-domain]  Cd Length: 467  Bit Score: 31.96  E-value: 9.14e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 446438696   7 IDLFSGAGGTTSGLKKSGIDVQVAVEIDSVAVKTYKLN 44
Cdd:PRK10458  92 IDLFAGIGGIRRGFEAIGGQCVFTSEWNKHAVRTYKAN 129
 
Name Accession Description Interval E-value
Dcm COG0270
DNA-cytosine methylase [Replication, recombination and repair];
1-51 5.25e-17

DNA-cytosine methylase [Replication, recombination and repair];


Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 70.99  E-value: 5.25e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446438696   1 MGKIVAIDLFSGAGGTTSGLKKSGIDVQVAVEIDSVAVKTYKLNNPEVSVI 51
Cdd:COG0270    1 SKKLTVIDLFAGAGGLSLGFEKAGFEVVFAVEIDPDACETYRANFPEAKVI 51
Cyt_C5_DNA_methylase cd00315
Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many ...
 7-51 6.96e-12

Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.


Pssm-ID: 238192 [Multi-domain]  Cd Length: 275  Bit Score: 57.24  E-value: 6.96e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 446438696   7 IDLFSGAGGTTSGLKKSGIDVQVAVEIDSVAVKTYKLNNPEVSVI 51
Cdd:cd00315    4 IDLFAGIGGFRLGLEKAGFEIVAANEIDKSAAETYEANFPNKLIE 48
DNA_methylase pfam00145
C-5 cytosine-specific DNA methylase;
7-52 7.35e-11

C-5 cytosine-specific DNA methylase;


Pssm-ID: 395093 [Multi-domain]  Cd Length: 324  Bit Score: 54.63  E-value: 7.35e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 446438696    7 IDLFSGAGGTTSGLKKSGIDVQVAVEIDSVAVKTYKLNNPEVSVID 52
Cdd:pfam00145   4 IDLFAGIGGFRLGLEQAGFECVAANEIDKSAAKTYEANFPKVPIGD 49
dcm TIGR00675
DNA-methyltransferase (dcm); All proteins in this family for which functions are known are ...
 7-47 1.47e-07

DNA-methyltransferase (dcm); All proteins in this family for which functions are known are DNA-cytosine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273211 [Multi-domain]  Cd Length: 315  Bit Score: 45.40  E-value: 1.47e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 446438696    7 IDLFSGAGGTTSGLKKSGIDVQVAVEIDSVAVKTYKLNNPE 47
Cdd:TIGR00675   2 IDLFAGIGGIRLGFEQAGFKCVFASEIDKYAQKTYEANFGN 42
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 5-39 8.24e-03

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 32.07  E-value: 8.24e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 446438696   5 VAIDLFSGAGGTTSGLKKSGIDVqVAVEIDSVAVK 39
Cdd:COG2265  236 RVLDLYCGVGTFALPLARRAKKV-IGVEIVPEAVE 269
PRK10458 PRK10458
DNA cytosine methylase; Provisional
 7-44 9.14e-03

DNA cytosine methylase; Provisional


Pssm-ID: 236696 [Multi-domain]  Cd Length: 467  Bit Score: 31.96  E-value: 9.14e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 446438696   7 IDLFSGAGGTTSGLKKSGIDVQVAVEIDSVAVKTYKLN 44
Cdd:PRK10458  92 IDLFAGIGGIRRGFEAIGGQCVFTSEWNKHAVRTYKAN 129
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 7-45 9.51e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 31.25  E-value: 9.51e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 446438696   7 IDLFSGAGGTTSGLKKSGIDVQVAVEIDSVAVKTYKLNN 45
Cdd:cd02440    3 LDLGCGTGALALALASGPGARVTGVDISPVALELARKAA 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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