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Conserved domains on  [gi|446439856|ref|WP_000517711|]
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MULTISPECIES: lipopolysaccharide assembly protein LapB [Bacillus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 24-317 5.49e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 78.23  E-value: 5.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  24 FYKKGMRAYKGQKLQDAIKYFRRAAQSEKE-PFILCQLAIALSEAGEYQESNQIFLKLARSNPELEQCYYFIANNYAYMG 102
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEALELDPEtVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 103 LFQQAKKYADRYLEVakekefvedtlelleimeeeamgaeeieDEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPE 182
Cdd:COG2956   91 LLDRAEELLEKLLEL----------------------------DPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 183 FWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAGQLVSVYPISFEHRLKLGTTL 262
Cdd:COG2956  143 NAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELY 222

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446439856 263 ATIGYFEHAYKWF-KVLKRQgyeGDVSFYYWFAYSAYMVKNQQVAEKMWQHVVELH 317
Cdd:COG2956  223 EKLGDPEEALELLrKALELD---PSDDLLLALADLLERKEGLEAALALLERQLRRH 275
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 24-317 5.49e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 78.23  E-value: 5.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  24 FYKKGMRAYKGQKLQDAIKYFRRAAQSEKE-PFILCQLAIALSEAGEYQESNQIFLKLARSNPELEQCYYFIANNYAYMG 102
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEALELDPEtVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 103 LFQQAKKYADRYLEVakekefvedtlelleimeeeamgaeeieDEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPE 182
Cdd:COG2956   91 LLDRAEELLEKLLEL----------------------------DPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 183 FWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAGQLVSVYPISFEHRLKLGTTL 262
Cdd:COG2956  143 NAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELY 222

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446439856 263 ATIGYFEHAYKWF-KVLKRQgyeGDVSFYYWFAYSAYMVKNQQVAEKMWQHVVELH 317
Cdd:COG2956  223 EKLGDPEEALELLrKALELD---PSDDLLLALADLLERKEGLEAALALLERQLRRH 275
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 157-362 1.22e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.16  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  157 ANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQ 236
Cdd:TIGR02917 506 ARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKK 585

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  237 VEALAGQLVSVYPISFEHRLKLGTTLATIGYFEHAYKWF-KVLKRQGYEGDVsfYYWFAYSAYMVKNQQVAEKMWQHVVE 315
Cdd:TIGR02917 586 ALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFkKLLALQPDSALA--LLLLADAYAVMKNYAKAITSLKRALE 663

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 446439856  316 LHPDKKGKEPWNALNLADEGQ----NVLFEELQKSFQQSATLEEQMLALYL 362
Cdd:TIGR02917 664 LKPDNTEAQIGLAQLLLAAKRtesaKKIAKSLQKQHPKAALGFELEGDLYL 714
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 155-217 2.06e-05

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 42.32  E-value: 2.06e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446439856  155 EEANRYIRNGQLEEAIATLEIVTKDY---PEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGN 217
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALARFpesPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGD 67
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 24-317 5.49e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 78.23  E-value: 5.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  24 FYKKGMRAYKGQKLQDAIKYFRRAAQSEKE-PFILCQLAIALSEAGEYQESNQIFLKLARSNPELEQCYYFIANNYAYMG 102
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEALELDPEtVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 103 LFQQAKKYADRYLEVakekefvedtlelleimeeeamgaeeieDEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPE 182
Cdd:COG2956   91 LLDRAEELLEKLLEL----------------------------DPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 183 FWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAGQLVSVYPISFEHRLKLGTTL 262
Cdd:COG2956  143 NAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELY 222

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446439856 263 ATIGYFEHAYKWF-KVLKRQgyeGDVSFYYWFAYSAYMVKNQQVAEKMWQHVVELH 317
Cdd:COG2956  223 EKLGDPEEALELLrKALELD---PSDDLLLALADLLERKEGLEAALALLERQLRRH 275
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 56-244 1.19e-15

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 79.65  E-value: 1.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  56 ILCQLAIALSEAGEYQESNQIFLKLARSNPELEQCYYFIANNYAYMGLFQQAKKYADRYLEVakekefvedtlelleime 135
Cdd:COG3914   80 LLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALAL------------------ 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 136 eeamgaeeieDEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNP 215
Cdd:COG3914  142 ----------NPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDP 211

                        170       180
                 ....*....|....*....|....*....
gi 446439856 216 GNIHALCNTLIFLYSIGEHKQVEALAGQL 244
Cdd:COG3914  212 DNADAHSNLLFALRQACDWEVYDRFEELL 240
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 154-345 9.73e-15

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 76.96  E-value: 9.73e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 154 QEEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGE 233
Cdd:COG3914   82 ELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGR 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 234 HKQVEALAGQLVSVYPISFEHRLKLGTTLATIGYFEHAYKWFkvlkRQGYEGDVSFYYWFA---YSAYMVKNQQVAEKMW 310
Cdd:COG3914  162 LEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAY----RRALELDPDNADAHSnllFALRQACDWEVYDRFE 237

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 446439856 311 QHVVELHPDKKGKEPWNALNLADEGQNVLFEELQK 345
Cdd:COG3914  238 ELLAALARGPSELSPFALLYLPDDDPAELLALARA 272
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
57-244 1.00e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.11  E-value: 1.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  57 LCQLAIALSEAGEYQESNQIFLKLARSNPELEQCYYFIANNYAYMGLFQQAKKYADRYLEVakekefvedtlelleimee 136
Cdd:COG0457   11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALEL------------------- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 137 eamgaeeieDEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPG 216
Cdd:COG0457   72 ---------DPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPD 142

                        170       180
                 ....*....|....*....|....*...
gi 446439856 217 NIHALCNTLIFLYSIGEHKQVEALAGQL 244
Cdd:COG0457  143 DADALYNLGIALEKLGRYEEALELLEKL 170
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
20-244 4.74e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 4.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  20 LADFFYKKGMRAYKGQKLQDAIKYFRRA-AQSEKEPFILCQLAIALSEAGEYQESNQIFLKLARSNPELEQCYYFIANNY 98
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKAlELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  99 AYMGLFQQAKKYADRYLEVakekefvedtlelleimeeeamgaeeieDEDDLIVMQEEANRYIRNGQLEEAIATLEIVTK 178
Cdd:COG0457   87 QALGRYEEALEDYDKALEL----------------------------DPDDAEALYNLGLALLELGRYDEAIEAYERALE 138

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446439856 179 DYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAGQL 244
Cdd:COG0457  139 LDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALE 204
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 59-217 4.38e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.89  E-value: 4.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  59 QLAIALSEAGEYQESNQIFLKLARSNPELEQCYYFIANNYAYMGLFQQAKKYADRYLEVakekefvedtlelleimeeea 138
Cdd:COG4783    9 ALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALEL--------------------- 67

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446439856 139 mgaeeieDEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGN 217
Cdd:COG4783   68 -------DPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
84-345 5.77e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 59.64  E-value: 5.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  84 NPELEQCYYFIANNYAYMGLFQQAKKYADRYLEVakekefvedtlelleimeeeamgaeeieDEDDLIVMQEEANRYIRN 163
Cdd:COG0457    4 DPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALEL----------------------------DPDDAEALYNLGLAYLRL 55

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 164 GQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAGQ 243
Cdd:COG0457   56 GRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYER 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 244 LVSVYPISFEHRLKLGTTLATIGYFEHAYKWFKVLKRQGYEGDVSFYYWFAYSAYMVKNQQVAEKMWQHVVELHPDKKGK 323
Cdd:COG0457  136 ALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILT 215

                        250       260
                 ....*....|....*....|..
gi 446439856 324 EPWNALNLADEGQNVLFEELQK 345
Cdd:COG0457  216 LAALAELLLLALALLLALRLAA 237
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 157-319 8.13e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 59.74  E-value: 8.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 157 ANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQ 236
Cdd:COG2956   49 GNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEK 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 237 VEALAGQLVSVYPISFEHRLKLGTTLATIGYFEHAYKWF-KVLKRqgYEGDVSFYYWFAYSAYMVKNQQVAEKMWQHVVE 315
Cdd:COG2956  129 AIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALeKALKL--DPDCARALLLLAELYLEQGDYEEAIAALERALE 206


                 ....
gi 446439856 316 LHPD 319
Cdd:COG2956  207 QDPD 210
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 98-251 1.77e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 56.51  E-value: 1.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  98 YAYMGLFQQAKKYADRYLEVAKEKEFVEDTLELLEIMEEEAMGAEEIEDEDDLIVMQEEANRYIRNGQLEEAIATLEIVT 177
Cdd:COG5010    2 RALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQAL 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446439856 178 KDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAGQLVSVYPIS 251
Cdd:COG5010   82 QLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSPLK 155
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 149-276 3.29e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.20  E-value: 3.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 149 DLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFL 228
Cdd:COG4783    3 CAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLAL 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446439856 229 YSIGEHKQVEALAGQLVSVYPISFEHRLKLGTTLATIGYFEHAYKWFK 276
Cdd:COG4783   83 LKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALE 130
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 21-120 6.46e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 51.73  E-value: 6.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  21 ADFFYKKGMRAYKGQKLQDAIKYFRRA-AQSEKEPFILCQLAIALSEAGEYQESNQIFLKLARSNPELEQCYYFIANNYA 99
Cdd:COG4783   38 PEAFALLGEILLQLGDLDEAIVLLHEAlELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYR 117

                         90       100
                 ....*....|....*....|.
gi 446439856 100 YMGLFQQAKKYADRYLEVAKE 120
Cdd:COG4783  118 ALGRPDEAIAALEKALELDPD 138
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
160-249 7.73e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 50.17  E-value: 7.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 160 YIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLtEMILEKNPGNIHALCNTLIFLYSIGEHKQVEA 239
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALA 80

                         90
                 ....*....|
gi 446439856 240 LAGQLVSVYP 249
Cdd:COG3063   81 YLERALELDP 90
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 30-120 1.60e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 50.39  E-value: 1.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  30 RAYKGQ-KLQDAIKYFRRAAQ-SEKEPFILCQLAIALSEAGEYQESNQIFLKLARSNPELEQCYYFIANNYAYMGLFQQA 107
Cdd:COG4235   25 RAYLRLgRYDEALAAYEKALRlDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEA 104

                         90
                 ....*....|...
gi 446439856 108 KKYADRYLEVAKE 120
Cdd:COG4235  105 IAAWQKLLALLPA 117
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 82-217 1.60e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 50.39  E-value: 1.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  82 RSNPELEQCYYFIANNYAYMGLFQQAKKYADRYLEVakekefvedtlelleimeeeamgaeeieDEDDLIVMQEEANRYI 161
Cdd:COG4235   11 AANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRL----------------------------DPDNADALLDLAEALL 62

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446439856 162 RNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGN 217
Cdd:COG4235   63 AAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPAD 118
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
19-171 5.77e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.78  E-value: 5.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  19 QLADFFYKKGMRAYKGQKLQDAIKYFRRA-AQSEKEPFILCQLAIALSEAGEYQESNQIFLKLARSNPELEQCYYFIANN 97
Cdd:COG0457   74 DDAEALNNLGLALQALGRYEEALEDYDKAlELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA 153

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446439856  98 YAYMGLFQQAKKYADRYLEVAKEKEFVEDTLELLEIMEEEAMGAEEIEDEDDLIVMQEEANRYIRNGQLEEAIA 171
Cdd:COG0457  154 LEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLAL 227
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
19-116 9.38e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.01  E-value: 9.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  19 QLADFFYKKGMRAYKGQKLQDAIKYFRRAAQSE-KEPFILCQLAIALSEAGEYQESNQIFLKLARSNPELEQCYYFIANN 97
Cdd:COG0457   40 DDAEALYNLGLAYLRLGRYEEALADYEQALELDpDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLA 119

                         90
                 ....*....|....*....
gi 446439856  98 YAYMGLFQQAKKYADRYLE 116
Cdd:COG0457  120 LLELGRYDEAIEAYERALE 138
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 146-249 1.20e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.88  E-value: 1.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 146 DEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTL 225
Cdd:COG4783   34 DPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLA 113

                         90       100
                 ....*....|....*....|....
gi 446439856 226 IFLYSIGEHKQVEALAGQLVSVYP 249
Cdd:COG4783  114 RAYRALGRPDEAIAALEKALELDP 137
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
155-241 2.93e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 48.37  E-value: 2.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 155 EEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEH 234
Cdd:COG4785   78 ERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRY 157


                 ....*..
gi 446439856 235 KqvEALA 241
Cdd:COG4785  158 E--LAIA 162
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 146-249 3.90e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.15  E-value: 3.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 146 DEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTL 225
Cdd:COG4235   13 NPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLG 92

                         90       100
                 ....*....|....*....|....
gi 446439856 226 IFLYSIGEHKQVEALAGQLVSVYP 249
Cdd:COG4235   93 LAAFQQGDYAEAIAAWQKLLALLP 116
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
36-120 4.79e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.16  E-value: 4.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  36 KLQDAIKYFRRA-AQSEKEPFILCQLAIALSEAGEYQESNQiFLKLARSNPELEQCYYFIANNYAYMGLFQQAKKYADRY 114
Cdd:COG3063    7 DLEEAEEYYEKAlELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERA 85


                 ....*.
gi 446439856 115 LEVAKE 120
Cdd:COG3063   86 LELDPS 91
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 168-281 5.58e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.77  E-value: 5.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 168 EAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAGQLVSV 247
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446439856 248 YPISFEHRLKLGTTLATIGYFEHAYKWFKVLKRQ 281
Cdd:COG4235   81 DPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLAL 114
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 157-362 1.22e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.16  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  157 ANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQ 236
Cdd:TIGR02917 506 ARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKK 585

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  237 VEALAGQLVSVYPISFEHRLKLGTTLATIGYFEHAYKWF-KVLKRQGYEGDVsfYYWFAYSAYMVKNQQVAEKMWQHVVE 315
Cdd:TIGR02917 586 ALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFkKLLALQPDSALA--LLLLADAYAVMKNYAKAITSLKRALE 663

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 446439856  316 LHPDKKGKEPWNALNLADEGQ----NVLFEELQKSFQQSATLEEQMLALYL 362
Cdd:TIGR02917 664 LKPDNTEAQIGLAQLLLAAKRtesaKKIAKSLQKQHPKAALGFELEGDLYL 714
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 36-116 1.24e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 45.34  E-value: 1.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  36 KLQDAIKYFRRAAQ-SEKEPFILCQLAIALSEAGEYQESNQIFLKLARSNPELEQCYYFIANNYAYMGLFQQAKKYADRY 114
Cdd:COG5010   69 DFEESLALLEQALQlDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRA 148


                 ..
gi 446439856 115 LE 116
Cdd:COG5010  149 LG 150
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 19-183 1.51e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.80  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  19 QLADFFYKKGMRAYKGQKLQDAIKYFRRAAQSEKE-PFILCQLAIALSEAGEYQESNQIFLKLARSNPELEQCYYFIANN 97
Cdd:COG4783    2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDnPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  98 YAYMGLFQQAKKYADRYLEvakekefvedtlelleimeeeamgaeeiEDEDDLIVMQEEANRYIRNGQLEEAIATLEIVT 177
Cdd:COG4783   82 LLKAGDYDEALALLEKALK----------------------------LDPEHPEAYLRLARAYRALGRPDEAIAALEKAL 133


                 ....*.
gi 446439856 178 KDYPEF 183
Cdd:COG4783  134 ELDPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 25-223 1.55e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.77  E-value: 1.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856   25 YKKGMRAYKGQKLQDAIKYFRRAAQSEKEPFILCQLA-IALSEAGEYQESNQIF---LKLARSNP---------ELEQCY 91
Cdd:TIGR02917 265 YLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAgASEYQLGNLEQAYQYLnqiLKYAPNSHqarrllasiQLRLGR 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856   92 Y---------FIANN-----------YAYMGL--FQQAKKY-----------ADRYLEVAKEKEFVEDTLELLEIMEEEA 138
Cdd:TIGR02917 345 VdeaiatlspALGLDpddpaalsllgEAYLALgdFEKAAEYlakateldpenAAARTQLGISKLSQGDPSEAIADLETAA 424

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  139 MGAEEIEDEDDLIVMQeeanrYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNI 218
Cdd:TIGR02917 425 QLDPELGRADLLLILS-----YLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFF 499


                  ....*
gi 446439856  219 HALCN 223
Cdd:TIGR02917 500 PAAAN 504
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 155-217 2.06e-05

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 42.32  E-value: 2.06e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446439856  155 EEANRYIRNGQLEEAIATLEIVTKDY---PEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGN 217
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALARFpesPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGD 67
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 156-271 3.61e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 3.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  156 EANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHK 235
Cdd:TIGR02917 233 LATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLE 312

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 446439856  236 QVEALAGQLVSVYPISFEHRLKLGTTLATIGYFEHA 271
Cdd:TIGR02917 313 QAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEA 348
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 13-122 1.01e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.98  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  13 QVISFN-QLADFFYKKGMRAYKGQKLQDAIKYFRRA-AQSEKEPFILCQLAIALSEAGEYQESNQIFLKLARSNPELEQC 90
Cdd:COG3914  137 RALALNpDFAEAYLNLGEALRRLGRLEEAIAALRRAlELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADA 216

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446439856  91 YYFIANNYAYMGLFQQAKKYADRYLEVAKEKE 122
Cdd:COG3914  217 HSNLLFALRQACDWEVYDRFEELLAALARGPS 248
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
146-215 2.40e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.15  E-value: 2.40e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 146 DEDDLIVMQEEANRYIRNGQLEEAIAtLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNP 215
Cdd:COG3063   22 DPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDP 90
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 29-116 3.55e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.97  E-value: 3.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  29 MRAYKGQKLQDAIKYFRRAAQ----SEKEPFILCQLAIALSEAGEYQESNQIFLKLARSNPE---LEQCYYFIANNYAYM 101
Cdd:COG1729    1 KALLKAGDYDEAIAAFKAFLKrypnSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDspkAPDALLKLGLSYLEL 80

                         90
                 ....*....|....*
gi 446439856 102 GLFQQAKKYADRYLE 116
Cdd:COG1729   81 GDYDKARATLEELIK 95
TPR_19 pfam14559
Tetratricopeptide repeat;
163-221 4.01e-04

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 38.72  E-value: 4.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446439856  163 NGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGN--IHAL 221
Cdd:pfam14559   1 EGDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDprYAAL 61
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 19-116 4.47e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.02  E-value: 4.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  19 QLADFFYKKGMRAYKGQKLQDAIKYFRRAAQSEKEPF-ILCQLAIALSEAGEYQESNQIFLKLARSNPELEQCYYFIANN 97
Cdd:COG2956  142 ENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCArALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAEL 221

                         90
                 ....*....|....*....
gi 446439856  98 YAYMGLFQQAKKYADRYLE 116
Cdd:COG2956  222 YEKLGDPEEALELLRKALE 240
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 190-319 5.42e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.18  E-value: 5.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 190 LAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAGQLVSVYPISFEHRLKLGTTLATIGYFE 269
Cdd:COG4783   10 LAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYD 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 446439856 270 HAykwfkvlkrqgyegdvsfyywfaysaymvknqqvaEKMWQHVVELHPD 319
Cdd:COG4783   90 EA-----------------------------------LALLEKALKLDPE 104
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 146-276 1.25e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.56  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 146 DEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTL 225
Cdd:COG5010   16 LLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLA 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446439856 226 IFLYSIGEHKQVEALAGQLVSVYPISFEHRLKLGTTLATIGYFEHAYKWFK 276
Cdd:COG5010   96 LLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQ 146
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 48-273 1.48e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856   48 AQSEKEPFILCQLAIALSEAGEYQESNQIFLKLARSNPELEQCYYFIANNYAYMGLFQQAKKYADRYlevakekefvedt 127
Cdd:TIGR02917  50 QKDPNDAEARFLLGKIYLALGDYAAAEKELRKALSLGYPKNQVLPLLARAYLLQGKFQQVLDELPGK------------- 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  128 lelleimeeeamgaeEIEDEDDLIVMQE-EANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKL 206
Cdd:TIGR02917 117 ---------------TLLDDEGAAELLAlRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARAL 181

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446439856  207 TEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAGQLVSVYPISFEHRLKLGTTLATIGYFEHAYK 273
Cdd:TIGR02917 182 IDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEK 248
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 62-182 2.93e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 37.66  E-value: 2.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  62 IALSEAGEYQESNQIFLKLARSNPE---LEQCYYFIANNYAYMGLFQQAKKYADRYLEVAKEKEFVEDtlelleimeeea 138
Cdd:COG1729    1 KALLKAGDYDEAIAAFKAFLKRYPNsplAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPD------------ 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446439856 139 mgaeeiededdliVMQEEANRYIRNGQLEEAIATLEIVTKDYPE 182
Cdd:COG1729   69 -------------ALLKLGLSYLELGDYDKARATLEELIKKYPD 99
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
193-276 3.28e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.07  E-value: 3.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856 193 AHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAgQLVSVYPISFEHRLKLGTTLATIGYFEHAY 272
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIALE-KALKLDPNNAEALLNLAELLLELGDYDEAL 79


                 ....
gi 446439856 273 KWFK 276
Cdd:COG3063   80 AYLE 83
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
19-116 5.60e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 38.36  E-value: 5.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  19 QLADFFYKKGMRAYKGQKLQDAIKYFRRAAQSE-KEPFILCQLAIALSEAGEYQESNQIFLKLARSNPELEQCYYFIANN 97
Cdd:COG4785   71 DLAQLYYERGVAYDSLGDYDLAIADFDQALELDpDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIA 150

                         90
                 ....*....|....*....
gi 446439856  98 YAYMGLFQQAKKYADRYLE 116
Cdd:COG4785  151 LYYLGRYELAIADLEKALE 169
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 148-266 6.88e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 6.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  148 DDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNvDKALKLTEMILEKNPgNIHALCNTL-I 226
Cdd:TIGR02917 768 NDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWLYLELKD-PRALEYAERALKLAP-NIPAILDTLgW 845

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 446439856  227 FLYSIGEHKQVEALAGQLVSVYPISFEHRLKLGTTLATIG 266
Cdd:TIGR02917 846 LLVEKGEADRALPLLRKAVNIAPEAAAIRYHLALALLATG 885
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
19-116 9.31e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 37.59  E-value: 9.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439856  19 QLADFFYKKGMRAYKGQKLQDAIKYFRRAAQSEKEPFILCQLAIALSEAGEYQESNQIFLKLARSNPELEQCYYFIANNY 98
Cdd:COG4785   38 AIALADLALALAAAALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAY 117

                         90
                 ....*....|....*...
gi 446439856  99 AYMGLFQQAKKYADRYLE 116
Cdd:COG4785  118 LLLGDYDAALEDFDRALE 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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