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Conserved domains on  [gi|446439878|ref|WP_000517733|]
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MULTISPECIES: lipopolysaccharide assembly protein LapB [Bacillus cereus group]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 24-317 1.30e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 79.77  E-value: 1.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  24 FYKKGMRAYKGQKLQDAIKYFRRAAQSEKE-PFILCQLATVLSEAGEYQESNQTFFKLVRSNPELEQCYYFIANNYAYMG 102
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEALELDPEtVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 103 LFQQAKKYADRYLEVaeekefvedtlelleimeeeamgaeeieDEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPE 182
Cdd:COG2956   91 LLDRAEELLEKLLEL----------------------------DPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 183 FWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAAQLVSVYPISFEHRLKLGTTL 262
Cdd:COG2956  143 NAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELY 222

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446439878 263 ATIGHFEPAYKWFKLLKRQgyEGDVSFYYWFAYSAYMVKDQQVAEKMWQHVVELH 317
Cdd:COG2956  223 EKLGDPEEALELLRKALEL--DPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 24-317 1.30e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 79.77  E-value: 1.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  24 FYKKGMRAYKGQKLQDAIKYFRRAAQSEKE-PFILCQLATVLSEAGEYQESNQTFFKLVRSNPELEQCYYFIANNYAYMG 102
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEALELDPEtVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 103 LFQQAKKYADRYLEVaeekefvedtlelleimeeeamgaeeieDEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPE 182
Cdd:COG2956   91 LLDRAEELLEKLLEL----------------------------DPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 183 FWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAAQLVSVYPISFEHRLKLGTTL 262
Cdd:COG2956  143 NAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELY 222

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446439878 263 ATIGHFEPAYKWFKLLKRQgyEGDVSFYYWFAYSAYMVKDQQVAEKMWQHVVELH 317
Cdd:COG2956  223 EKLGDPEEALELLRKALEL--DPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 25-243 3.36e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 49.70  E-value: 3.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878   25 YKKGMRAYKGQKLQDAIKYFRRAAQSEKEPFILCQLA-TVLSEAGEYQESNQTFFKLVRSNPELEQCYYFIANNYAYMGL 103
Cdd:TIGR02917 265 YLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAgASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGR 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  104 FQQAKkyadRYLEVAEEKefvedtlelleimeeeamgaeeieDEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEF 183
Cdd:TIGR02917 345 VDEAI----ATLSPALGL------------------------DPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPEN 396

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  184 WSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHAlcNTLIFLYSIGEHKQVEALAAQ 243
Cdd:TIGR02917 397 AAARTQLGISKLSQGDPSEAIADLETAAQLDPELGRA--DLLLILSYLRSGQFDKALAAA 454
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 155-217 2.69e-05

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 41.94  E-value: 2.69e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446439878  155 EEANRYIRNGQLEEAIATLEIVTKDY---PEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGN 217
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALARFpesPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGD 67
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 24-317 1.30e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 79.77  E-value: 1.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  24 FYKKGMRAYKGQKLQDAIKYFRRAAQSEKE-PFILCQLATVLSEAGEYQESNQTFFKLVRSNPELEQCYYFIANNYAYMG 102
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEALELDPEtVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 103 LFQQAKKYADRYLEVaeekefvedtlelleimeeeamgaeeieDEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPE 182
Cdd:COG2956   91 LLDRAEELLEKLLEL----------------------------DPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 183 FWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAAQLVSVYPISFEHRLKLGTTL 262
Cdd:COG2956  143 NAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELY 222

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446439878 263 ATIGHFEPAYKWFKLLKRQgyEGDVSFYYWFAYSAYMVKDQQVAEKMWQHVVELH 317
Cdd:COG2956  223 EKLGDPEEALELLRKALEL--DPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 89-345 2.39e-16

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 81.96  E-value: 2.39e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  89 QCYYFIANNYAYMGLFQQAKKYADRYLEVAEEKEFVEDTLELLEIMEEEAMGAEEIEDEDDLIVM--QEEANRYIRNGQL 166
Cdd:COG3914   15 AALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAllELAALLLQALGRY 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 167 EEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAAQLVS 246
Cdd:COG3914   95 EEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALE 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 247 VYPISFEHRLKLGTTLATIGHFEPAYKWFkllkRQGYEGDVSFYYWFA---YSAYMVKDQQVAEKMWQHVVELHPDKKGK 323
Cdd:COG3914  175 LDPDNAEALNNLGNALQDLGRLEEAIAAY----RRALELDPDNADAHSnllFALRQACDWEVYDRFEELLAALARGPSEL 250

                        250       260
                 ....*....|....*....|..
gi 446439878 324 EPWNALNLADEGQSVLFEELRK 345
Cdd:COG3914  251 SPFALLYLPDDDPAELLALARA 272
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 56-244 9.07e-15

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 76.96  E-value: 9.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  56 ILCQLATVLSEAGEYQESNQTFFKLVRSNPELEQCYYFIANNYAYMGLFQQAKKYADRYLEVaeekefvedtlelleime 135
Cdd:COG3914   80 LLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALAL------------------ 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 136 eeamgaeeieDEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNP 215
Cdd:COG3914  142 ----------NPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDP 211

                        170       180
                 ....*....|....*....|....*....
gi 446439878 216 GNIHALCNTLIFLYSIGEHKQVEALAAQL 244
Cdd:COG3914  212 DNADAHSNLLFALRQACDWEVYDRFEELL 240
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
57-244 8.69e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.11  E-value: 8.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  57 LCQLATVLSEAGEYQESNQTFFKLVRSNPELEQCYYFIANNYAYMGLFQQAKKYADRYLEVaeekefvedtlelleimee 136
Cdd:COG0457   11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALEL------------------- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 137 eamgaeeieDEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPG 216
Cdd:COG0457   72 ---------DPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPD 142

                        170       180
                 ....*....|....*....|....*...
gi 446439878 217 NIHALCNTLIFLYSIGEHKQVEALAAQL 244
Cdd:COG0457  143 DADALYNLGIALEKLGRYEEALELLEKL 170
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
20-244 2.41e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 2.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  20 LADFFYKKGMRAYKGQKLQDAIKYFRRA-AQSEKEPFILCQLATVLSEAGEYQESNQTFFKLVRSNPELEQCYYFIANNY 98
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKAlELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  99 AYMGLFQQAKKYADRYLEVaeekefvedtlelleimeeeamgaeeieDEDDLIVMQEEANRYIRNGQLEEAIATLEIVTK 178
Cdd:COG0457   87 QALGRYEEALEDYDKALEL----------------------------DPDDAEALYNLGLALLELGRYDEAIEAYERALE 138

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446439878 179 DYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAAQL 244
Cdd:COG0457  139 LDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALE 204
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
84-312 1.08e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.95  E-value: 1.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  84 NPELEQCYYFIANNYAYMGLFQQAKKYADRYLEVaeekefvedtlelleimeeeamgaeeieDEDDLIVMQEEANRYIRN 163
Cdd:COG0457    4 DPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALEL----------------------------DPDDAEALYNLGLAYLRL 55

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 164 GQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAAQ 243
Cdd:COG0457   56 GRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYER 135

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446439878 244 LVSVYPISFEHRLKLGTTLATIGHFEPAYKWFKLLKRQGYEGDVSFYYWFAYSAYMVKDQQVAEKMWQH 312
Cdd:COG0457  136 ALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALE 204
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 149-281 4.64e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.89  E-value: 4.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 149 DLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFL 228
Cdd:COG4783    3 CAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLAL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446439878 229 YSIGEHKQVEALAAQLVSVYPISFEHRLKLGTTLATIGHFEPAYKWFKLLKRQ 281
Cdd:COG4783   83 LKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 157-319 5.23e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.13  E-value: 5.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 157 ANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQ 236
Cdd:COG2956   49 GNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEK 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 237 VEALAAQLVSVYPISFEHRLKLGTTLATIGHFEPAYKWFKLLkRQGYEGDVSFYYWFAYSAYMVKDQQVAEKMWQHVVEL 316
Cdd:COG2956  129 AIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKA-LKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQ 207


                 ...
gi 446439878 317 HPD 319
Cdd:COG2956  208 DPD 210
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 98-251 7.45e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 57.66  E-value: 7.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  98 YAYMGLFQQAKKYADRYLEVAEEKEFVEDTLELLEIMEEEAMGAEEIEDEDDLIVMQEEANRYIRNGQLEEAIATLEIVT 177
Cdd:COG5010    2 RALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQAL 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446439878 178 KDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAAQLVSVYPIS 251
Cdd:COG5010   82 QLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSPLK 155
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
160-360 9.17e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 59.25  E-value: 9.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 160 YIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEA 239
Cdd:COG0457   18 YRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALE 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 240 LAAQLVSVYPISFEHRLKLGTTLATIGHFEPAYKWF-KLLKRQgyEGDVSFYYWFAYSAYMVKDQQVAEKMWQHVVELHP 318
Cdd:COG0457   98 DYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYeRALELD--PDDADALYNLGIALEKLGRYEEALELLEKLEAAAL 175

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 446439878 319 DKKGKEPWNALNLADEGQSVLFEELRKSFQQSATLEEQMLAL 360
Cdd:COG0457  176 AALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLA 217
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 59-217 5.75e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.43  E-value: 5.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  59 QLATVLSEAGEYQESNQTFFKLVRSNPELEQCYYFIANNYAYMGLFQQAKKYADRYLEVaeekefvedtlelleimeeea 138
Cdd:COG4783    9 ALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALEL--------------------- 67

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446439878 139 mgaeeieDEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGN 217
Cdd:COG4783   68 -------DPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
160-249 4.10e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 50.94  E-value: 4.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 160 YIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLtEMILEKNPGNIHALCNTLIFLYSIGEHKQVEA 239
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALA 80

                         90
                 ....*....|
gi 446439878 240 LAAQLVSVYP 249
Cdd:COG3063   81 YLERALELDP 90
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 81-217 9.33e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 50.77  E-value: 9.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  81 VRSNPELEQCYYFIANNYAYMGLFQQAKKYADRYLEVaeekefvedtlelleimeeeamgaeeieDEDDLIVMQEEANRY 160
Cdd:COG4235   10 LAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRL----------------------------DPDNADALLDLAEAL 61

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446439878 161 IRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGN 217
Cdd:COG4235   62 LAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPAD 118
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 30-120 2.18e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 50.00  E-value: 2.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  30 RAYKGQ-KLQDAIKYFRRAAQ-SEKEPFILCQLATVLSEAGEYQESNQTFFKLVRSNPELEQCYYFIANNYAYMGLFQQA 107
Cdd:COG4235   25 RAYLRLgRYDEALAAYEKALRlDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEA 104

                         90
                 ....*....|...
gi 446439878 108 KKYADRYLEVAEE 120
Cdd:COG4235  105 IAAWQKLLALLPA 117
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 168-280 2.25e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 49.62  E-value: 2.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 168 EAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAAQLVSV 247
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446439878 248 YPISFEHRLKLGTTLATIGHFEPAYK-WFKLLKR 280
Cdd:COG4235   81 DPDNPEALYLLGLAAFQQGDYAEAIAaWQKLLAL 114
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 146-249 5.42e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.03  E-value: 5.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 146 DEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTL 225
Cdd:COG4783   34 DPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLA 113

                         90       100
                 ....*....|....*....|....
gi 446439878 226 IFLYSIGEHKQVEALAAQLVSVYP 249
Cdd:COG4783  114 RAYRALGRPDEAIAALEKALELDP 137
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 21-120 6.20e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 48.65  E-value: 6.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  21 ADFFYKKGMRAYKGQKLQDAIKYFRRA-AQSEKEPFILCQLATVLSEAGEYQESNQTFFKLVRSNPELEQCYYFIANNYA 99
Cdd:COG4783   38 PEAFALLGEILLQLGDLDEAIVLLHEAlELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYR 117

                         90       100
                 ....*....|....*....|.
gi 446439878 100 YMGLFQQAKKYADRYLEVAEE 120
Cdd:COG4783  118 ALGRPDEAIAALEKALELDPD 138
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
19-116 8.03e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.39  E-value: 8.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  19 QLADFFYKKGMRAYKGQKLQDAIKYFRRAAQSE-KEPFILCQLATVLSEAGEYQESNQTFFKLVRSNPELEQCYYFIANN 97
Cdd:COG0457   40 DDAEALYNLGLAYLRLGRYEEALADYEQALELDpDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLA 119

                         90
                 ....*....|....*....
gi 446439878  98 YAYMGLFQQAKKYADRYLE 116
Cdd:COG0457  120 LLELGRYDEAIEAYERALE 138
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
36-120 1.67e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 46.32  E-value: 1.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  36 KLQDAIKYFRRA-AQSEKEPFILCQLATVLSEAGEYQESnQTFFKLVRSNPELEQCYYFIANNYAYMGLFQQAKKYADRY 114
Cdd:COG3063    7 DLEEAEEYYEKAlELDPDNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERA 85


                 ....*.
gi 446439878 115 LEVAEE 120
Cdd:COG3063   86 LELDPS 91
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 146-249 2.58e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.92  E-value: 2.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 146 DEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTL 225
Cdd:COG4235   13 NPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLG 92

                         90       100
                 ....*....|....*....|....
gi 446439878 226 IFLYSIGEHKQVEALAAQLVSVYP 249
Cdd:COG4235   93 LAAFQQGDYAEAIAAWQKLLALLP 116
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
155-241 3.30e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 48.37  E-value: 3.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 155 EEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEH 234
Cdd:COG4785   78 ERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRY 157


                 ....*..
gi 446439878 235 KqvEALA 241
Cdd:COG4785  158 E--LAIA 162
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 25-243 3.36e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 49.70  E-value: 3.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878   25 YKKGMRAYKGQKLQDAIKYFRRAAQSEKEPFILCQLA-TVLSEAGEYQESNQTFFKLVRSNPELEQCYYFIANNYAYMGL 103
Cdd:TIGR02917 265 YLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAgASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGR 344

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  104 FQQAKkyadRYLEVAEEKefvedtlelleimeeeamgaeeieDEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEF 183
Cdd:TIGR02917 345 VDEAI----ATLSPALGL------------------------DPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPEN 396

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  184 WSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHAlcNTLIFLYSIGEHKQVEALAAQ 243
Cdd:TIGR02917 397 AAARTQLGISKLSQGDPSEAIADLETAAQLDPELGRA--DLLLILSYLRSGQFDKALAAA 454
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 19-183 8.07e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.57  E-value: 8.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  19 QLADFFYKKGMRAYKGQKLQDAIKYFRRAAQSEKE-PFILCQLATVLSEAGEYQESNQTFFKLVRSNPELEQCYYFIANN 97
Cdd:COG4783    2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDnPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  98 YAYMGLFQQAKKYADRYLEvaeekefvedtlelleimeeeamgaeeiEDEDDLIVMQEEANRYIRNGQLEEAIATLEIVT 177
Cdd:COG4783   82 LLKAGDYDEALALLEKALK----------------------------LDPEHPEAYLRLARAYRALGRPDEAIAALEKAL 133


                 ....*.
gi 446439878 178 KDYPEF 183
Cdd:COG4783  134 ELDPDD 139
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 155-217 2.69e-05

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 41.94  E-value: 2.69e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446439878  155 EEANRYIRNGQLEEAIATLEIVTKDY---PEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGN 217
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALARFpesPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGD 67
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 36-116 8.97e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.03  E-value: 8.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  36 KLQDAIKYFRRAAQ-SEKEPFILCQLATVLSEAGEYQESNQTFFKLVRSNPELEQCYYFIANNYAYMGLFQQAKKYADRY 114
Cdd:COG5010   69 DFEESLALLEQALQlDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRA 148


                 ..
gi 446439878 115 LE 116
Cdd:COG5010  149 LG 150
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 48-273 1.01e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.07  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878   48 AQSEKEPFILCQLATVLSEAGEYQESNQTFFKLVRSNPELEQCYYFIANNYAYMGLFQQAkkyadryLEVAEEKEfvedt 127
Cdd:TIGR02917  50 QKDPNDAEARFLLGKIYLALGDYAAAEKELRKALSLGYPKNQVLPLLARAYLLQGKFQQV-------LDELPGKT----- 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  128 lelleimeeeamgaeeIEDEDDLIVMQE-EANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKL 206
Cdd:TIGR02917 118 ----------------LLDDEGAAELLAlRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARAL 181

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446439878  207 TEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAAQLVSVYPISFEHRLKLGTTLATIGHFEPAYK 273
Cdd:TIGR02917 182 IDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEK 248
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 13-122 2.08e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.83  E-value: 2.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  13 QVISFN-QLADFFYKKGMRAYKGQKLQDAIKYFRRA-AQSEKEPFILCQLATVLSEAGEYQESNQTFFKLVRSNPELEQC 90
Cdd:COG3914  137 RALALNpDFAEAYLNLGEALRRLGRLEEAIAALRRAlELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADA 216

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446439878  91 YYFIANNYAYMGLFQQAKKYADRYLEVAEEKE 122
Cdd:COG3914  217 HSNLLFALRQACDWEVYDRFEELLAALARGPS 248
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
146-215 2.47e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.15  E-value: 2.47e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 146 DEDDLIVMQEEANRYIRNGQLEEAIAtLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNP 215
Cdd:COG3063   22 DPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDP 90
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 156-265 3.26e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.53  E-value: 3.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  156 EANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHK 235
Cdd:TIGR02917 233 LATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLE 312

                          90       100       110
                  ....*....|....*....|....*....|
gi 446439878  236 QvealAAQLVSVYPISFEHRLKLGTTLATI 265
Cdd:TIGR02917 313 Q----AYQYLNQILKYAPNSHQARRLLASI 338
TPR_19 pfam14559
Tetratricopeptide repeat;
163-221 4.30e-04

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 38.72  E-value: 4.30e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446439878  163 NGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGN--IHAL 221
Cdd:pfam14559   1 EGDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDprYAAL 61
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 146-276 4.85e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 40.71  E-value: 4.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 146 DEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTL 225
Cdd:COG5010   16 LLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLA 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446439878 226 IFLYSIGEHKQVEALAAQLVSVYPISFEHRLKLGTTLATIGHFEPAYKWFK 276
Cdd:COG5010   96 LLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQ 146
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 190-319 5.12e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.18  E-value: 5.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 190 LAIAHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALAAQLVSVYPISFEHRLKLGTTLATIGHFE 269
Cdd:COG4783   10 LAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYD 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 446439878 270 PAykwfkllkrqgyegdvsfyywfaysaymvkdqqvaEKMWQHVVELHPD 319
Cdd:COG4783   90 EA-----------------------------------LALLEKALKLDPE 104
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 19-116 8.98e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.25  E-value: 8.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  19 QLADFFYKKGMRAYKGQKLQDAIKYFRRAAQSEKEPF-ILCQLATVLSEAGEYQESNQTFFKLVRSNPELEQCYYFIANN 97
Cdd:COG2956  142 ENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCArALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAEL 221

                         90
                 ....*....|....*....
gi 446439878  98 YAYMGLFQQAKKYADRYLE 116
Cdd:COG2956  222 YEKLGDPEEALELLRKALE 240
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
193-276 1.35e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.23  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 193 AHFQSGNVDKALKLTEMILEKNPGNIHALCNTLIFLYSIGEHKQVEALaAQLVSVYPISFEHRLKLGTTLATIGHFEPAY 272
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEAL 79


                 ....
gi 446439878 273 KWFK 276
Cdd:COG3063   80 AYLE 83
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 29-116 2.26e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 38.05  E-value: 2.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  29 MRAYKGQKLQDAIKYFRRAAQ----SEKEPFILCQLATVLSEAGEYQESNQTFFKLVRSNPE---LEQCYYFIANNYAYM 101
Cdd:COG1729    1 KALLKAGDYDEAIAAFKAFLKrypnSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDspkAPDALLKLGLSYLEL 80

                         90
                 ....*....|....*
gi 446439878 102 GLFQQAKKYADRYLE 116
Cdd:COG1729   81 GDYDKARATLEELIK 95
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 148-266 5.32e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.68  E-value: 5.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  148 DDLIVMQEEANRYIRNGQLEEAIATLEIVTKDYPEFWSGHNNLAIAHFQSGNvDKALKLTEMILEKNPgNIHALCNTL-I 226
Cdd:TIGR02917 768 NDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWLYLELKD-PRALEYAERALKLAP-NIPAILDTLgW 845

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 446439878  227 FLYSIGEHKQVEALAAQLVSVYPISFEHRLKLGTTLATIG 266
Cdd:TIGR02917 846 LLVEKGEADRALPLLRKAVNIAPEAAAIRYHLALALLATG 885
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 160-249 8.50e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.12  E-value: 8.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878 160 YIRNGQLEEAIATLEIVTKDYPE---FWSGHNNLAIAHFQSGNVDKALKLTEMILEKNPGNIH---ALCNTLIFLYSIGE 233
Cdd:COG1729    3 LLKAGDYDEAIAAFKAFLKRYPNsplAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYLELGD 82

                         90
                 ....*....|....*.
gi 446439878 234 HKQVEALAAQLVSVYP 249
Cdd:COG1729   83 YDKARATLEELIKKYP 98
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 27-319 8.74e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 38.81  E-value: 8.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878   27 KGMRAYKGQKLQDAIKYFRRAAQSEKEPFILCQLATVLSEAGEYQESNQTFFKLVRSNPELEQCYYFIANNYAYMGlfqq 106
Cdd:TIGR00990 133 KGNKAYRNKDFNKAIKLYSKAIECKPDPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNRRANAYDGLG---- 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  107 akKYADRYLEVAE-------EKEFVEDTLELLEIMEEEAMGAEEIEDEDDLIVMQEEANRYIRNGQLEEAIATLEIVTKD 179
Cdd:TIGR00990 209 --KYADALLDLTAsciidgfRNEQSAQAVERLLKKFAESKAKEILETKPENLPSVTFVGNYLQSFRPKPRPAGLEDSNEL 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446439878  180 YPEFWSGHNNLAIAHFQSG---NVDKALKLTEMILEKN---PGNIHALCNTLIFLYSIGEHKQVEALAAQLVSVYPISFE 253
Cdd:TIGR00990 287 DEETGNGQLQLGLKSPESKadeSYEEAARAFEKALDLGklgEKEAIALNLRGTFKCLKGKHLEALADLSKSIELDPRVTQ 366

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446439878  254 HRLKLGTTLATIGHFEPAYKWF-KLLKRQGYEGDVsfYYWFAYSAYMVKDQQVAEKMWQHVVELHPD 319
Cdd:TIGR00990 367 SYIKRASMNLELGDPDKAEEDFdKALKLNSEDPDI--YYHRAQLHFIKGEFAQAGKDYQKSIDLDPD 431
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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