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Conserved domains on  [gi|446448853|ref|WP_000526708|]
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mannitol dehydrogenase family protein [Escherichia coli]

Protein Classification

mannitol dehydrogenase family protein( domain architecture ID 11415531)

mannitol dehydrogenase family protein similar to Aspergillus fumigatus mannitol 2-dehydrogenase, which catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway

EC:  1.1.1.-
Gene Ontology:  GO:0016616
PubMed:  30945211
SCOP:  4000105

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MtlD COG0246
Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism];
6-483 0e+00

Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism];


:

Pssm-ID: 440016 [Multi-domain]  Cd Length: 492  Bit Score: 724.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853   6 LSAKATLPVYDRNNLAPRIVHLGFGAFHRAHQGVYADILATEHFSDWGYYEVNLIGGEQQIADLQQQDNLYTVAEMSADA 85
Cdd:COG0246   12 LPAGVARPAYDRSALPPGIVHFGVGNFHRAHQAWYTDRLLNAGDFDWGIVGVGLRSGDALRDALAAQDGLYTLVERGPDG 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853  86 -WTARVVGVVKKALHVQIDGlETVLAAMCEPQIAIVSLTITEKGYFHSPATGQLMLDHPMVVADVQNPHQPKTATGVIVE 164
Cdd:COG0246   92 vEEARVIGSISEVLVAPEDP-EAVLALLADPALRIVSLTITEKGYCLDPATGELDLDHPDIQADLANPAPPRSAPGKLTA 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 165 ALARRKAAGLPAFTVMSCDNMPENGHVMRDVVTSYAQAIDVKLAQWIEDNVTFPSTMVDRIVPAVTEDTLAKIEQLTGVR 244
Cdd:COG0246  171 ALYRRRAAGLKPFTVLSCDNLPHNGDVLREAVLAFARLWDPELADWIEENVTFPNTMVDRIVPATTDEDRARLAAELGYE 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 245 DPAGVACEPFRQWVIEDNFVAGRPEWEKAGVELVSDVLPYEEMKLRMLNGSHSFLAYLGYLAGYQHINDCMEDEHYRHAA 324
Cdd:COG0246  251 DAAPVVAEPFRQWVIEDDFPAGRPPLEKAGVQFVDDVAPYEEMKLRLLNGSHTALAYLGYLAGYETVAEAMADPLLRAFV 330
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 325 YTLMLQEQAPTLK-VQGVDLQDYANRLIARYSNPALRHRTWQIAMDGSQKLPQRMLDSVRWHLAHDSKFDLLALGVAGWM 403
Cdd:COG0246  331 RRLMLEEIIPTLPpPPGVDLEAYADAVLERFANPAIRHTLARIALDGSQKLPQRLLPTLRDYLAAGRDPKRLALAVAAWL 410
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 404 RYVGGVDEQGNPIEISDPLLPVIQKAVQSSAEGTARVQSLLAIKAIFGDDLPDNSLFTTKVTEAYLSLLAHGAKATVAKY 483
Cdd:COG0246  411 RYLRGVDDDGEPIELSDPLADELAALAAAADDPADLVRAFLALEAIFGDDLADDPGFVEAVTAALEELLAKGARATLAAL 490
 
Name Accession Description Interval E-value
MtlD COG0246
Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism];
6-483 0e+00

Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism];


Pssm-ID: 440016 [Multi-domain]  Cd Length: 492  Bit Score: 724.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853   6 LSAKATLPVYDRNNLAPRIVHLGFGAFHRAHQGVYADILATEHFSDWGYYEVNLIGGEQQIADLQQQDNLYTVAEMSADA 85
Cdd:COG0246   12 LPAGVARPAYDRSALPPGIVHFGVGNFHRAHQAWYTDRLLNAGDFDWGIVGVGLRSGDALRDALAAQDGLYTLVERGPDG 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853  86 -WTARVVGVVKKALHVQIDGlETVLAAMCEPQIAIVSLTITEKGYFHSPATGQLMLDHPMVVADVQNPHQPKTATGVIVE 164
Cdd:COG0246   92 vEEARVIGSISEVLVAPEDP-EAVLALLADPALRIVSLTITEKGYCLDPATGELDLDHPDIQADLANPAPPRSAPGKLTA 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 165 ALARRKAAGLPAFTVMSCDNMPENGHVMRDVVTSYAQAIDVKLAQWIEDNVTFPSTMVDRIVPAVTEDTLAKIEQLTGVR 244
Cdd:COG0246  171 ALYRRRAAGLKPFTVLSCDNLPHNGDVLREAVLAFARLWDPELADWIEENVTFPNTMVDRIVPATTDEDRARLAAELGYE 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 245 DPAGVACEPFRQWVIEDNFVAGRPEWEKAGVELVSDVLPYEEMKLRMLNGSHSFLAYLGYLAGYQHINDCMEDEHYRHAA 324
Cdd:COG0246  251 DAAPVVAEPFRQWVIEDDFPAGRPPLEKAGVQFVDDVAPYEEMKLRLLNGSHTALAYLGYLAGYETVAEAMADPLLRAFV 330
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 325 YTLMLQEQAPTLK-VQGVDLQDYANRLIARYSNPALRHRTWQIAMDGSQKLPQRMLDSVRWHLAHDSKFDLLALGVAGWM 403
Cdd:COG0246  331 RRLMLEEIIPTLPpPPGVDLEAYADAVLERFANPAIRHTLARIALDGSQKLPQRLLPTLRDYLAAGRDPKRLALAVAAWL 410
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 404 RYVGGVDEQGNPIEISDPLLPVIQKAVQSSAEGTARVQSLLAIKAIFGDDLPDNSLFTTKVTEAYLSLLAHGAKATVAKY 483
Cdd:COG0246  411 RYLRGVDDDGEPIELSDPLADELAALAAAADDPADLVRAFLALEAIFGDDLADDPGFVEAVTAALEELLAKGARATLAAL 490
PRK15037 PRK15037
D-mannonate oxidoreductase; Provisional
13-481 0e+00

D-mannonate oxidoreductase; Provisional


Pssm-ID: 184997 [Multi-domain]  Cd Length: 486  Bit Score: 621.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853  13 PVYDRNNLAPRIVHLGFGAFHRAHQGVYADILATEHFSDWGYYEVNLIGGEQQ--IADLQQQDNLYTVAEMSADAWTARV 90
Cdd:PRK15037  14 PSWDHSRLESRIVHLGCGAFHRAHQALYTHHLLESTDSDWGICEVNLMPGNDRvlIENLKKQQLLYTVAEKGAESTELKI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853  91 VGVVKKALHVQIDGLETVLAAMCEPQIAIVSLTITEKGYFHSPATGQLMLDHPMVVADVQNPHQPKTATGVIVEALARRK 170
Cdd:PRK15037  94 IGSMKEALHPEIDGCEGILNAMARPQTAIVSLTVTEKGYCADAASGQLDLNNPLIKHDLENPTAPKSAIGYIVEALRLRR 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 171 AAGLPAFTVMSCDNMPENGHVMRDVVTSYAQAIDVKLAQWIEDNVTFPSTMVDRIVPAVTEDTLAKIEQLTGVRDPAGVA 250
Cdd:PRK15037 174 EKGLKAFTVMSCDNVRENGHVAKVAVLGLAQARDPQLAAWIEENVTFPCTMVDRIVPAATPETLQEIADQLGVYDPCAIA 253
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 251 CEPFRQWVIEDNFVAGRPEWEKAGVELVSDVLPYEEMKLRMLNGSHSFLAYLGYLAGYQHINDCMEDEHYRHAAYTLMLQ 330
Cdd:PRK15037 254 CEPFRQWVIEDNFVNGRPDWDKVGAQFVADVVPFEMMKLRMLNGSHSFLAYLGYLGGYETIADTMTNPAYRKAAFALMMQ 333
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 331 EQAPTLKV-QGVDLQDYANRLIARYSNPALRHRTWQIAMDGSQKLPQRMLDSVRWHLAHDSKFDLLALGVAGWMRYVGGV 409
Cdd:PRK15037 334 EQAPTLSMpEGTDLNAYATLLIERFSNPSLRHRTWQIAMDGSQKLPQRLLDPVRLHLQNGGSWRHLALGVAGWMRYTQGV 413
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446448853 410 DEQGNPIEISDPLLPVIQKaVQSSAEGTARVQSLLAIKAIFGDDLPDNSLFTTKVTEAYLSLLAHGAKATVA 481
Cdd:PRK15037 414 DEQGNAIDVVDPMLAEFQK-INAQYQGADRVKALLGLSGIFADDLPQNADFVGAVTAAYQQLCERGARECVA 484
Mannitol_dh_C pfam08125
Mannitol dehydrogenase C-terminal domain;
213-460 7.53e-142

Mannitol dehydrogenase C-terminal domain;


Pssm-ID: 369700  Cd Length: 246  Bit Score: 406.77  E-value: 7.53e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853  213 DNVTFPSTMVDRIVPAVTEDTLAKIEQLTGVRDPAGVACEPFRQWVIEDNFVAGRPEWEKAGVELVSDVLPYEEMKLRML 292
Cdd:pfam08125   1 DNVGFPNTMVDRIVPATTDDELAKIAQALGVEDPLPVTVEPFRQWVIEDNFVKGRPLLEKVGVEYVEDVDPYEERKLRIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853  293 NGSHSFLAYLGYLAGYQHINDCMEDEHYRHAAYTLMLQEQAPTL-KVQGVDLQDYANRLIARYSNPALRHRTWQIAMDGS 371
Cdd:pfam08125  81 NGGHATLAYLGYLAGYQTIHEAMLDPEIRAFVKGVMTEEVAPLLaKVPGDDLEAYADKIIERFSNPYIKDTVWRVARDGS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853  372 QKLPQRMLDSVRWHLAHDSKFDLLALGVAGWMRYVGGVDEQGNPIEISDPLLPVIQKAVQSSAEgtaRVQSLLAIKAIFG 451
Cdd:pfam08125 161 QKLPQRKLPSLRRHIRAGPLPELLALGVAGWMRYLQGVDEGGNYIDPEDPQAQELQAAAIIAKE---RPAAVLAEVSGLG 237

                  ....*....
gi 446448853  452 DDLPDNSLF 460
Cdd:pfam08125 238 DDLAQNSEF 246
 
Name Accession Description Interval E-value
MtlD COG0246
Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism];
6-483 0e+00

Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism];


Pssm-ID: 440016 [Multi-domain]  Cd Length: 492  Bit Score: 724.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853   6 LSAKATLPVYDRNNLAPRIVHLGFGAFHRAHQGVYADILATEHFSDWGYYEVNLIGGEQQIADLQQQDNLYTVAEMSADA 85
Cdd:COG0246   12 LPAGVARPAYDRSALPPGIVHFGVGNFHRAHQAWYTDRLLNAGDFDWGIVGVGLRSGDALRDALAAQDGLYTLVERGPDG 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853  86 -WTARVVGVVKKALHVQIDGlETVLAAMCEPQIAIVSLTITEKGYFHSPATGQLMLDHPMVVADVQNPHQPKTATGVIVE 164
Cdd:COG0246   92 vEEARVIGSISEVLVAPEDP-EAVLALLADPALRIVSLTITEKGYCLDPATGELDLDHPDIQADLANPAPPRSAPGKLTA 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 165 ALARRKAAGLPAFTVMSCDNMPENGHVMRDVVTSYAQAIDVKLAQWIEDNVTFPSTMVDRIVPAVTEDTLAKIEQLTGVR 244
Cdd:COG0246  171 ALYRRRAAGLKPFTVLSCDNLPHNGDVLREAVLAFARLWDPELADWIEENVTFPNTMVDRIVPATTDEDRARLAAELGYE 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 245 DPAGVACEPFRQWVIEDNFVAGRPEWEKAGVELVSDVLPYEEMKLRMLNGSHSFLAYLGYLAGYQHINDCMEDEHYRHAA 324
Cdd:COG0246  251 DAAPVVAEPFRQWVIEDDFPAGRPPLEKAGVQFVDDVAPYEEMKLRLLNGSHTALAYLGYLAGYETVAEAMADPLLRAFV 330
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 325 YTLMLQEQAPTLK-VQGVDLQDYANRLIARYSNPALRHRTWQIAMDGSQKLPQRMLDSVRWHLAHDSKFDLLALGVAGWM 403
Cdd:COG0246  331 RRLMLEEIIPTLPpPPGVDLEAYADAVLERFANPAIRHTLARIALDGSQKLPQRLLPTLRDYLAAGRDPKRLALAVAAWL 410
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 404 RYVGGVDEQGNPIEISDPLLPVIQKAVQSSAEGTARVQSLLAIKAIFGDDLPDNSLFTTKVTEAYLSLLAHGAKATVAKY 483
Cdd:COG0246  411 RYLRGVDDDGEPIELSDPLADELAALAAAADDPADLVRAFLALEAIFGDDLADDPGFVEAVTAALEELLAKGARATLAAL 490
PRK15037 PRK15037
D-mannonate oxidoreductase; Provisional
13-481 0e+00

D-mannonate oxidoreductase; Provisional


Pssm-ID: 184997 [Multi-domain]  Cd Length: 486  Bit Score: 621.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853  13 PVYDRNNLAPRIVHLGFGAFHRAHQGVYADILATEHFSDWGYYEVNLIGGEQQ--IADLQQQDNLYTVAEMSADAWTARV 90
Cdd:PRK15037  14 PSWDHSRLESRIVHLGCGAFHRAHQALYTHHLLESTDSDWGICEVNLMPGNDRvlIENLKKQQLLYTVAEKGAESTELKI 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853  91 VGVVKKALHVQIDGLETVLAAMCEPQIAIVSLTITEKGYFHSPATGQLMLDHPMVVADVQNPHQPKTATGVIVEALARRK 170
Cdd:PRK15037  94 IGSMKEALHPEIDGCEGILNAMARPQTAIVSLTVTEKGYCADAASGQLDLNNPLIKHDLENPTAPKSAIGYIVEALRLRR 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 171 AAGLPAFTVMSCDNMPENGHVMRDVVTSYAQAIDVKLAQWIEDNVTFPSTMVDRIVPAVTEDTLAKIEQLTGVRDPAGVA 250
Cdd:PRK15037 174 EKGLKAFTVMSCDNVRENGHVAKVAVLGLAQARDPQLAAWIEENVTFPCTMVDRIVPAATPETLQEIADQLGVYDPCAIA 253
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 251 CEPFRQWVIEDNFVAGRPEWEKAGVELVSDVLPYEEMKLRMLNGSHSFLAYLGYLAGYQHINDCMEDEHYRHAAYTLMLQ 330
Cdd:PRK15037 254 CEPFRQWVIEDNFVNGRPDWDKVGAQFVADVVPFEMMKLRMLNGSHSFLAYLGYLGGYETIADTMTNPAYRKAAFALMMQ 333
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 331 EQAPTLKV-QGVDLQDYANRLIARYSNPALRHRTWQIAMDGSQKLPQRMLDSVRWHLAHDSKFDLLALGVAGWMRYVGGV 409
Cdd:PRK15037 334 EQAPTLSMpEGTDLNAYATLLIERFSNPSLRHRTWQIAMDGSQKLPQRLLDPVRLHLQNGGSWRHLALGVAGWMRYTQGV 413
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446448853 410 DEQGNPIEISDPLLPVIQKaVQSSAEGTARVQSLLAIKAIFGDDLPDNSLFTTKVTEAYLSLLAHGAKATVA 481
Cdd:PRK15037 414 DEQGNAIDVVDPMLAEFQK-INAQYQGADRVKALLGLSGIFADDLPQNADFVGAVTAAYQQLCERGARECVA 484
Mannitol_dh_C pfam08125
Mannitol dehydrogenase C-terminal domain;
213-460 7.53e-142

Mannitol dehydrogenase C-terminal domain;


Pssm-ID: 369700  Cd Length: 246  Bit Score: 406.77  E-value: 7.53e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853  213 DNVTFPSTMVDRIVPAVTEDTLAKIEQLTGVRDPAGVACEPFRQWVIEDNFVAGRPEWEKAGVELVSDVLPYEEMKLRML 292
Cdd:pfam08125   1 DNVGFPNTMVDRIVPATTDDELAKIAQALGVEDPLPVTVEPFRQWVIEDNFVKGRPLLEKVGVEYVEDVDPYEERKLRIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853  293 NGSHSFLAYLGYLAGYQHINDCMEDEHYRHAAYTLMLQEQAPTL-KVQGVDLQDYANRLIARYSNPALRHRTWQIAMDGS 371
Cdd:pfam08125  81 NGGHATLAYLGYLAGYQTIHEAMLDPEIRAFVKGVMTEEVAPLLaKVPGDDLEAYADKIIERFSNPYIKDTVWRVARDGS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853  372 QKLPQRMLDSVRWHLAHDSKFDLLALGVAGWMRYVGGVDEQGNPIEISDPLLPVIQKAVQSSAEgtaRVQSLLAIKAIFG 451
Cdd:pfam08125 161 QKLPQRKLPSLRRHIRAGPLPELLALGVAGWMRYLQGVDEGGNYIDPEDPQAQELQAAAIIAKE---RPAAVLAEVSGLG 237

                  ....*....
gi 446448853  452 DDLPDNSLF 460
Cdd:pfam08125 238 DDLAQNSEF 246
Mannitol_dh pfam01232
Mannitol dehydrogenase Rossmann domain;
22-185 3.99e-57

Mannitol dehydrogenase Rossmann domain;


Pssm-ID: 395986 [Multi-domain]  Cd Length: 151  Bit Score: 186.46  E-value: 3.99e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853   22 PRIVHLGFGAFHRAHQGvYADILATEHFSDWGYYEVNLIGGEQqIADLQQQDNLYTVAEMSADAWTARVVGVVKKALHVQ 101
Cdd:pfam01232   1 MRIVHFGAGNFHRAHQA-FIGDLLAENGFDWGIVDVNLRVVDA-REALNAQDGLYTVIEDGEEGRQARLVGSVNAVNSVE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853  102 IDgLETVLAAMCEPQIAIVSLTITEKGYFHspaTGQLMLDHPMVVADVQNPHqpktatgVIVEALARRKAAGLPAFTVMS 181
Cdd:pfam01232  79 ED-LEALIELMAEPQADIVSTTVTEGGIDA---TGQLDNDLPDIAADLAKPE-------YLVEALKRRRAAGLKPLTIIA 147

                  ....
gi 446448853  182 CDNM 185
Cdd:pfam01232 148 CDNM 151
PRK03643 PRK03643
tagaturonate reductase;
69-472 4.93e-48

tagaturonate reductase;


Pssm-ID: 235147 [Multi-domain]  Cd Length: 471  Bit Score: 171.95  E-value: 4.93e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853  69 LQQQDNLYTVA--------EMSadawTARVVGVVKKALHVQIDgLETVLAAMCEPQIA-IVSLTiTEKGY-FHspATGQL 138
Cdd:PRK03643  62 LNEQDGLYTLIirglnegeAVS----EARLIRSISREINPYSD-WDEFLKLARNPELRfVFSNT-TEAGIsYH--AEDKF 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 139 MlDHPmvvadvqnphqPKTATGVIVEALARR-------KAAGLpafTVMSCDNMPENGHVMRDVVTSYAQ--AIDVKLAQ 209
Cdd:PRK03643 134 D-DAP-----------PVSFPAKLTALLYERfkhfngaADKGL---IIIPCELIDYNGEKLKEIVLRYAQewNLPEAFIQ 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 210 WIEDNVTFPSTMVDRIVPAVTEDTLAKIEQLTGVRDPAGVACEPFRQWVIE-DNFVAGRPEWEKAG--VELVSDVLPYEE 286
Cdd:PRK03643 199 WLEEANTFCSTLVDRIVTGYPRDEAAALEEELGYEDGLLDTAEPFYLWVIEgPKSLAKELPFDKAGlnVLIVDDIKPYRE 278
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 287 MKLRMLNGSHSFLAYLGYLAGYQHINDCMEDEHYRHAAYTLMLQEQAPTLKVQGVDLQDYANRLIARYSNPALRHRTWQI 366
Cdd:PRK03643 279 RKVRILNGAHTALVPVAYLAGLDTVGEAMEDAEIGAFVEKAIYEEIIPVLDLPEDELESFAEAVLDRFRNPFIKHQLLSI 358
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 367 AMDGSQKLPQRMLDSVrwhLAHDSKFD----LLALGVAGWMR-YVGGVDEQGNPIEISDPLLPVIQKAVQSSAEGTAR-- 439
Cdd:PRK03643 359 ALNSMSKFRTRILPQL---LAYQERKGtlpaRLTFALAALIAfYRGERNGETYPIQDDAHWLERFKQLWSQVDDGEISla 435
                        410       420       430
                 ....*....|....*....|....*....|....*
gi 446448853 440 --VQSLLAIKAIFGDDLPDNSLFTTKVTEAYLSLL 472
Cdd:PRK03643 436 elVAAVLSDEKHWGQDLTQVPGLVEQVTEYLQAIL 470
PRK02318 PRK02318
mannitol-1-phosphate 5-dehydrogenase; Provisional
160-359 9.65e-29

mannitol-1-phosphate 5-dehydrogenase; Provisional


Pssm-ID: 235031 [Multi-domain]  Cd Length: 381  Bit Score: 116.84  E-value: 9.65e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 160 GVIVEALARRKAAG-LPAFTVMSCDNMpenghVMrdvVTSY-AQAI----DVKLAQWIEDNVTFPSTMVDRIVPAVTEDt 233
Cdd:PRK02318  98 PLIAKGLKKRKAQGnTKPLNIIACENM-----IR---GTSFlKKHVlkalSEDEKAWLEEHVGFVDSAVDRIVPAQKNE- 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446448853 234 lakieqltgvrDPAGVACEPFRQWVIEDNFVAGRPEwEKAGVELVSDVLPYEEMKLRMLNGSHSFLAYLGYLAGYQHIND 313
Cdd:PRK02318 169 -----------DPLDVTVEPFSEWIVDKTQFKGALP-KIKGMEYVDNLMPFIERKLFTVNTGHATTAYLGYLKGYKTIRE 236
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 446448853 314 CMEDEHYRHAAYTLMLQEQAPTLKVQGVD---LQDYANRLIARYSNPAL 359
Cdd:PRK02318 237 AILDPSIRAVVKGALEESGAVLIKKYGFDkeeHAAYIEKILGRFENPYL 285
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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