|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10133 |
PRK10133 |
L-fucose:H+ symporter permease; |
1-438 |
0e+00 |
|
L-fucose:H+ symporter permease;
Pssm-ID: 182260 [Multi-domain] Cd Length: 438 Bit Score: 821.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 1 MGNTSIQTQSYRAVDKDAGQSRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIP 80
Cdd:PRK10133 1 MGNTSIQTQSYRAVDKDAGQSRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 81 AGILMKKLSYKAGIITGLFLYALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQT 160
Cdd:PRK10133 81 AGILMKKLSYKAGIITGLFLYALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 161 FNSFGAIIAVVFGQSLILSNVPHQSQDVLDKMSPEQLSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHS 240
Cdd:PRK10133 161 FNSFGAIIAVVFGQSLILSNVPHQSQDVLDKMTPEQLSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 241 DAKQGSFSASLSRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVEEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLIS 320
Cdd:PRK10133 241 DAKQGSFSASLSRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVEEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLIS 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 321 RFAPHKVLAAYALIAMALCLISAFAGGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPV 400
Cdd:PRK10133 321 RFAPHKVLAAYALIAMALCLISAFAGGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPV 400
|
410 420 430
....*....|....*....|....*....|....*...
gi 446450748 401 MGFVSDAAGNIPTAELIPALCFAVIFIFARFRSQTATN 438
Cdd:PRK10133 401 MGFVSDAAGNIPTAELIPALCFAVIFIFARFRSQTATN 438
|
|
| fucP |
TIGR00885 |
L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. ... |
24-429 |
0e+00 |
|
L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. L-fucose(6-deoxy-L-galactose) is a monosaccharide found in glycoproteins and cell wall polysaccharides. L-fucose is used in bacteria through an inducible pathway mediated by atleast four enzymes: a permease, isomerase, kinase and an aldolase which are encoded by fucP, fucI, fucK, fucA respectively. The fuc genes belong to a regulon comprising of four linked operons: fucO, fucA, fucPIK and fucR. The positive regulator is encoded by fucR, whose protein responds to fuculose-1-phosphate, which acts as an effector. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 211614 Cd Length: 408 Bit Score: 591.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 24 YIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYAL 103
Cdd:TIGR00885 1 YIIPFALITSLFALWGFANDITNPMVPQFQQAFTLTAFQAALVQSAFYGGYFIMAIPAAIFMKKLSYKAGILLGLFLYAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 104 GAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILSNVPH 183
Cdd:TIGR00885 81 GAFLFWPAAEIMNYTLFLVGLFILTAGLGFLETAANPYILVMGPESTATRRLNLAQSFNPFGSIIGMVVAQQLILSNLPH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 184 QSQDVLDKMSPEQLSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALqsdNHSDAKQGSFSASLSRLARIRHWRWA 263
Cdd:TIGR00885 161 QSQDVLDKLSPEELSAIKHSDLASVQTPYMIIGAVVLAVALLIMLTKMPAL---NHSDAKQISFSASLSRLARIRHYREG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 264 VLAQFCYVGAQTACWSYLIRYAVEEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCLISA 343
Cdd:TIGR00885 238 VIAQFFYVGVQIMCWTFIIQYAVRLIPGMTAGFAANYNIGAMVIFFISRFIGTWLISYLAAHKVLMAYAIIGMALCLGSI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 344 FAGGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVMGFVSD-----AAGNIPTAELIP 418
Cdd:TIGR00885 318 FAGGHVGLYCLTLCSAFMSLMFPTIYGIALKGLGQDTKYGAAGLVMAIIGGGIVPPLQGFIIDmkeiaAAPAVNTSFILP 397
|
410
....*....|.
gi 446450748 419 ALCFAVIFIFA 429
Cdd:TIGR00885 398 LLCFAVIFIYG 408
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
28-431 |
2.09e-158 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 453.22 E-value: 2.09e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 28 FALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAAL 107
Cdd:cd17394 1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 108 FWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILSNVPHQSQD 187
Cdd:cd17394 81 FIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPSTATA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 188 VLdKMSPEQLSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQGsfsASLSRLARIRHWRWAVLAQ 267
Cdd:cd17394 161 LA-AMSAAELQAYKTAELASVQLPYLGIALVLLLLAVLILLSKLPEIEAAEAEALGSK---GTLLRLLKNPHLRLGVLAI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 268 FCYVGAQTACWSYLIRYAVEEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCLISAFAGG 347
Cdd:cd17394 237 FFYVGAEVAIWSFLINYLMEYIAGLTETSAATFVSYYWGGFMVGRFLGTALLKKISPKKLLAVFALLGLLLLLGAIFTGG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 348 HVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVMGFVSDAAGNIPTAELIPALCFAVIFI 427
Cdd:cd17394 317 MVALYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGAVADDAAGLRIAFLVPLLCFAYILF 396
|
....
gi 446450748 428 FARF 431
Cdd:cd17394 397 YGLR 400
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
20-431 |
2.24e-91 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 281.74 E-value: 2.24e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 20 QSRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLF 99
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 100 LYALGAALFwpaAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHfRLNLAQTFNSFGAIIAVVFGQSLILS 179
Cdd:COG0738 82 LMALGLLLF---ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAS-RLNLLHAFFSLGALLGPLLGGLLILL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 180 NVPhqsqdvldkmspeqlsaykhslvLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDnhsDAKQGSFSASLSRLARIRH 259
Cdd:COG0738 158 GLS-----------------------LSWHLPYLILAVLLLLLALLFLRSKLPEIEEE---EEEAAGSAASLKSLLKNPR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 260 WRWAVLAQFCYVGAQTACWSYLIRYAVeEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALC 339
Cdd:COG0738 212 LLLGGLAIFLYVGAEGAIGDWLPLYLK-DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 340 LISAFAGG-HVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDT-KYGSSFIVMTIIGGGIVTPVMGFVSDAAGnIPTAELI 417
Cdd:COG0738 291 LLALLAPGpWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTaAAVSAVLIMGIVGGAIGPPLIGFLADAFG-LRAAFLV 369
|
410
....*....|....
gi 446450748 418 PALCFAVIFIFARF 431
Cdd:COG0738 370 PLVCYLLILLLALA 383
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
31-431 |
4.04e-83 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 259.95 E-value: 4.04e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 31 LCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFWP 110
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 111 AAEIMnytLFLVGLFIIAAGLGCLETAANPFVTVLGPESSgHFRLNLAQTFNSFGAIIAVVFGQSLILSnvphqsqdvld 190
Cdd:cd17333 81 TPSIY---LFVVLMFLAGLGAGILDTGANTFVGALFEESS-ATRLNVLHGFFGLGALIGPLIATSLLTS----------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 191 kmspeqlsaykhslVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQGSFSASLSRLARIRHWRWAVLAQFCY 270
Cdd:cd17333 146 --------------ELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 271 VGAQTACWSYLIRYAVEEiPGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCLISAFAGG-HV 349
Cdd:cd17333 212 VGAETAFSSWVPSYLVEK-KHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTlVV 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 350 GLIALTLCSAFMSIQYPTIFSLGIKNLG-QDTKYGSSFIVMTIIGGGIVTPVMGFVsDAAGNIPTAELIPALCFAVIFIF 428
Cdd:cd17333 291 GLVATALLGLFMAALFPTILSLGISNLPyAKGKGTSVLLAAGSIGGAIIPFIMGFI-AEAVGIQTAMLLITILYAIIFVL 369
|
...
gi 446450748 429 ARF 431
Cdd:cd17333 370 ALL 372
|
|
| gluP |
TIGR01272 |
glucose/galactose transporter; This model describes the glucose/galactose transporter in ... |
108-428 |
4.26e-41 |
|
glucose/galactose transporter; This model describes the glucose/galactose transporter in bacteria. This belongs to the larger facilitator superfamily. Disruption of the loci leads to the total loss of glucose or galactose uptake in E.coli. Putative transporters in other bacterial species were isolated by functional complementation, which restored it functional activity. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273531 [Multi-domain] Cd Length: 310 Bit Score: 148.51 E-value: 4.26e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 108 FWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILSNVPHQSQD 187
Cdd:TIGR01272 1 FGPAASQRYYVLFLGALFVLASGLTILQVAANPYVSILGPIETAASRLALTQAFNKLGTTVAPLFGGSLILSGAGDLSMQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 188 VldkmspeqlsAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQGSFSASLSRLaRIRHWRWAVLAQ 267
Cdd:TIGR01272 81 V----------ATANAEAAKVHTPYLLLAGALAVLAIIFAFLPLPELQEADVARVSSGDTTQKTSAF-QFTHLVLGALGI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 268 FCYVGAQTACWSYLIRYAVEE-IPGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCLISAFAG 346
Cdd:TIGR01272 150 FVYVGAEVSAGSFLVNFLSDPhALGLPEDQAAHFTAYTWGGAMVGRFIGSAVMPMISQGRYLAFNAFLAVLLSIGAALTH 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 347 GHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVMGFVSDAAGnIPTAELIPALCFAVIF 426
Cdd:TIGR01272 230 GYVAMWFVLALGLFNSIMFPTIFSLALNALGRHTSQGSGILCLAIVGGAIVPLLQGSLADCLG-IQLAFALPVPCYLYIL 308
|
..
gi 446450748 427 IF 428
Cdd:TIGR01272 309 FY 310
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
31-429 |
1.40e-26 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 110.21 E-value: 1.40e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 31 LCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFWP 110
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 111 AAeimNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILsnvphqsqdvld 190
Cdd:cd06174 81 AP---SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS------------ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 191 kmspeqlsaykhSLVLSVQTPYMI--IVAIVLLVALLIMLTKFPALQSDNHSDAKQGSFSASLSRLARIRHWRWAVLAQF 268
Cdd:cd06174 146 ------------SLGFGWRAVFLIaaALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIF 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 269 CYVGAQTACWSYLIRYAVEEIpGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCLISAFAGGH 348
Cdd:cd06174 214 LVNLAYYSFSTLLPLFLLDLG-GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPS 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 349 --VGLIALTLCSAFMSIQYPTIFSLGIKN--LGQDTKYGSSFIVMTIIGGGIVTPVMGFVSDAAGNIPTAELIPALCFAV 424
Cdd:cd06174 293 llLLLLLLLLLGFGLGGLLPLSFALIAELfpPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLL 372
|
....*
gi 446450748 425 IFIFA 429
Cdd:cd06174 373 AAILL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
20-396 |
1.70e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 86.18 E-value: 1.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 20 QSRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLF 99
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 100 LYALGAALFWPAaeiMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLIls 179
Cdd:COG2814 84 LFALGSLLCALA---PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 180 nvphqsqdvldkmspeqlsaykhsLVLSVQTPYMIIVAIVLLVALLIMLTKfpalqsDNHSDAKQGSFSASLSRLARIRH 259
Cdd:COG2814 159 ------------------------DLFGWRWVFLVNAVLALLALLLLLRLL------PESRPAARARLRGSLRELLRRPR 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 260 WRWAVLAQFCYVGAQTACWSYLIRYAVEEIpGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVL-AAYALIAMAL 338
Cdd:COG2814 209 LLLLLLLAFLLGFGFFALFTYLPLYLQEVL-GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLlIGLLLLALGL 287
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446450748 339 CLISAFAGGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGI 396
Cdd:COG2814 288 LLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
28-436 |
7.17e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 84.54 E-value: 7.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 28 FALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAAL 107
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 108 FwpaAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILSnvphqsqd 187
Cdd:COG2271 92 F---GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA-------- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 188 vldkmspeqlsaykhslvLSVQTPYMIIVAIVLLVALLIMLtkfpalqsdnhsdakqgsfsaslsrlarirhwrWAVLAQ 267
Cdd:COG2271 161 ------------------FGWRAAFLILGLPGLLLALLRFW---------------------------------LLALAY 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 268 FCYVGAQTACWSYLIRYAVEEIpGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHK---VLAAYALIAMALCLISAF 344
Cdd:COG2271 190 FLVYFALYGFLTWLPTYLVEVR-GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklvLAIGLLLAALALLLLALL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 345 AGGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTI--IGGGIVTPVMGFVSDAAGNIPTAELIPALCF 422
Cdd:COG2271 269 PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFgfLGGALGPLLVGYLLDATGYQAAFLLLAALAL 348
|
410
....*....|....
gi 446450748 423 AVIFIFARFRSQTA 436
Cdd:COG2271 349 LAALLALLLLRETR 362
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
28-432 |
6.63e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 76.07 E-value: 6.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 28 FALLCSLFFLWAVannlndiLLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAAL 107
Cdd:COG2223 14 FFLAFGVWYLWSV-------LAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 108 FWPAAeimNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILSnvphqsqd 187
Cdd:COG2223 87 LALAV---SYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAA-------- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 188 vldkmspeqlsaykhslvLSVQTPYMIIVAIVLLVALLIMLTKFPAlqSDNHSDAKQGSFsASLSRLARIRHWRWAVLAQ 267
Cdd:COG2223 156 ------------------FGWRNAFLILGILLLVVAVLAWLFLRDP--PAGAAAAAKASL-RDQLEALRDPRFWLLSLLY 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 268 FCYVGAQTACWSYLIRYAVEEIpGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCLISAFAGG 347
Cdd:COG2223 215 FGTFGSFIGFSSWLPPYLVDQF-GLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 348 HVGL--IALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTI--IGGGIVTPVMGFVSDAAGNIPTAELIPALCFA 423
Cdd:COG2223 294 SLWLflVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAggLGGFLGPLLFGALLDATGSYTAAFLVFAVLAL 373
|
....*....
gi 446450748 424 VIFIFARFR 432
Cdd:COG2223 374 VALVLTLLL 382
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
48-429 |
9.08e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 72.20 E-value: 9.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 48 LLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFWPAAeimNYTLFLVGLFII 127
Cdd:cd17324 21 LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP---SFALLLLARALA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 128 AAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLilsnvphqsqdvldkmspeqlsaykhSLVLS 207
Cdd:cd17324 98 GLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL--------------------------GQLLG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 208 VQTPYMIIVAIVLLVALLIMLTkFPALQSDNhsdAKQGSFSASLSRLARIRHWRWAVLAQFCYVGAQTACWSYlIRYAVE 287
Cdd:cd17324 152 WRAAFLAIAVLALLAALLLWRL-LPSLPPKK---PGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTY-LAPFLT 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 288 EIPGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCLISAFAGGHVGLIALT-LCSAFMSIQYP 366
Cdd:cd17324 227 DVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLvLWGLGFFAAHS 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446450748 367 TIFSLGIKNLGQDTKYGSSFIVMTI-IGGGIVTPVMGFVSDAAGNIPTAELIPALCFAVIFIFA 429
Cdd:cd17324 307 ALQTRVLRLAPEARGLASSLYLAAYnLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
48-432 |
9.19e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 69.14 E-value: 9.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 48 LLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFwpaAEIMNYTLFLVGLFII 127
Cdd:cd17325 18 ILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF---AFATSYWQLLLARFLQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 128 AAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLIlsnvphqsqdvldkmspeqlsaykhsLVLS 207
Cdd:cd17325 95 GLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA--------------------------DALG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 208 VQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQGSFSASLSRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVE 287
Cdd:cd17325 149 YRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 288 EIpGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFaPHKVLAAYALIAMALCLIS-AFAGGHVGLIALT-LCSAFMSIQY 365
Cdd:cd17325 229 LG-GLSPAQIGLLFGAQGLASALSQPPAGKLSDRI-GRKPLILIGLLLSAVALLLlPLATSFWLLLLLLaLLGLGLGLVF 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 366 PTIFSLGIKNLGQDtKYGSSF-IVMTIIGGGIVT--PVMGFVSDAAGNIPTAELIPALCFAVIFIFARFR 432
Cdd:cd17325 307 PATLALLADIVPPE-GRGTAMgLFNTAFSLGMVLgpLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
30-397 |
2.07e-12 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 67.83 E-value: 2.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 30 LLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFW 109
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 110 PAAeimNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILSnvphqsqdvl 189
Cdd:pfam07690 81 FAS---SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL---------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 190 dkmspeqlsaykhslvLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQGSFSASLSRLARIRHWRWAVLAQFC 269
Cdd:pfam07690 148 ----------------FGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 270 YVGAQTACWSYLIRYAveEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHK----VLAAYALIAMALCLISAFA 345
Cdd:pfam07690 212 FGFAFFGLLTYLPLYQ--EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrlllALLLLILAALGLLLLSLTL 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446450748 346 GGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIV 397
Cdd:pfam07690 290 SSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGA 341
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
94-431 |
2.65e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 65.31 E-value: 2.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 94 IITGLFLYALGAALFW---PAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLN-LAQTFNSFGAIIA 169
Cdd:COG2211 84 ILIGAIPLALSFVLLFtapDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSsWRFAFAGLGGLLA 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 170 VVFGQSLIlsnvphqsqdvldkmspeqlsaykHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQGSFSA 249
Cdd:COG2211 164 SVLPPPLV------------------------AAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKE 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 250 SLSRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVEEIpGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLA 329
Cdd:COG2211 220 SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL-GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFI 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 330 AYALIAMALCLISAFAGGH---VGLIALTLCSAFMSIQYPTIFSL-------GIKNLGQDT--KYGSSFIVMTIIGGGIV 397
Cdd:COG2211 299 IGLLLAALGLLLLFFLGPGnlwLLLVLAALAGIGLGAILVLPWAMladvvdyDEWKTGRRRegLYFGIFTFAIKLGQALA 378
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 446450748 398 TPVMGFVSDAAGNIPTAE--------------LIPALCFAVIFIFARF 431
Cdd:COG2211 379 GALAGLLLALFGYVAGAAqspsaltgirllffLLPAVLLLLAALLLLF 426
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
28-431 |
2.93e-09 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 58.42 E-value: 2.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 28 FALLCSLFFLWAVannlndiLLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKA-----GIITGLFLYA 102
Cdd:cd17393 8 FFINGILMASWAT-------RIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRvtrlgALLLLLALLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 103 LGAALFWPAaeimnytlFLVGLFIIAAGLGCLETAANpfvtVLGPESSGHFRLNLAQTFN---SFGAIIAVVFGQSLILS 179
Cdd:cd17393 81 LGLAPSVPA--------LALALFLFGAANGALDVAMN----AQGVAVERAYGRPIMSSLHamwSLGGLAGALLGAAAIGA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 180 NVPhqsqdvldkmspeqlsaykhslvlsvQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQGSFSAsLSRLARIRH 259
Cdd:cd17393 149 GVS--------------------------PGVHLLAAAVLLLLAALVAIRALLPGTGEAAEDRPDGAGKP-GFLLPNRLL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 260 WRWAVLAQFCYVGAQTAC-WSYLIRYAVEEIPGMTAGFAANYLTGTMVcffIGRFTGTWLISRFAPHKVLAAYALIAMAL 338
Cdd:cd17393 202 LLLGLLALAAALAEGAAAdWSALYLRDVLGASAALAALGYAVFSLAMT---VGRLFGDRLVDRFGDVAVLRAGALLAALG 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 339 CLISAFAGGHVGLIALTLCSAF-MSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTP-VMGFVSDAAGnIPTAEL 416
Cdd:cd17393 279 LLLALLAPSVWVALAGFALMGLgLSVVVPLAFSAAGALPGLAAGIAVARVATLGYLGFLVGPpLIGFLADATG-LRTAFL 357
|
410
....*....|....*
gi 446450748 417 IPALCFAVIFIFARF 431
Cdd:cd17393 358 VVALLALLVALLARA 372
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
48-432 |
3.29e-09 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 58.35 E-value: 3.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 48 LLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFWPAAeimNYTLFLVGLFII 127
Cdd:COG2807 40 LLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP---SVALLLAGTALI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 128 AAGLGCLETAANPFVTVLGPESSGhFRLNLAQTFNSFGAIIAVVFGQSLILSnvphqsqdvldkmspeqlsaykhslvLS 207
Cdd:COG2807 117 GAGIAVGNVLLPGLIKRWFPDRVG-LMTGLYTAAMGLGAALAAGLTVPLAAA--------------------------LG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 208 VQTPYMIIVAIVLLVALLIMLtkfpaLQSDNHSDAKQGSFSASLSRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVE 287
Cdd:COG2807 170 WRGALAVWALLALLALLLWLP-----LLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 288 EipGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHK-VLAAYALIAMALCLISAFAGGHVGLIALTLCSAFMSIQYP 366
Cdd:COG2807 245 A--GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRpLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFP 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446450748 367 TIFSLGIKNLGQDTKYG--SSFIVMT-IIGGGIVTPVMGFVSDAAGNiPTAELIPALCFAVIFIFARFR 432
Cdd:COG2807 323 LALTLIGLRARTPAEAAalSGMAQSVgYLLAALGPLLVGALHDATGS-WTAALLLLAALAVLMLVAGLL 390
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
35-431 |
4.85e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.60 E-value: 4.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 35 FFLWAVANNLNdILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFWPAAEI 114
Cdd:cd17489 6 FFFFLSFYLLL-PVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 115 mnyTLFLVGLFIIAAGLGCLETAANPFVTVLGPESsghfRLNLAQTFNSFGAIIAVVFGQSLILSNVPHQSQDVLdkmsp 194
Cdd:cd17489 85 ---ALLLVLRLIHGIGWGAFTTAAATLVADIIPPS----RRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVL----- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 195 eqlsaykhslvlsvqtpYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQGSFSASLSRLArIRHWRWAVLAQFCYVGAQ 274
Cdd:cd17489 153 -----------------FIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKV-LPPALILFLASIAYGAIS 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 275 TacwsYLIRYAVEEipGMTAgfAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLA-AYALIAMALCLISAFAGGHVGLIA 353
Cdd:cd17489 215 T----FLPLYAAER--GISN--AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIpGLLLLALGLLLLSFAGSPWMLLLA 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 354 LTLCSAFMSIQYPTIFSLGIKNLGQdTKYGSSFIVMTI---IGGGIVTPVMGFVSDAAGnIPTAELIPALCFAVIFIFAR 430
Cdd:cd17489 287 AVLYGLGFGLLFPALQALAVDLVPP-HRRGAANGTFFIffdLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYI 364
|
.
gi 446450748 431 F 431
Cdd:cd17489 365 F 365
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
47-429 |
2.49e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 55.64 E-value: 2.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 47 ILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFwpaAEIMNYTLFLVGLFI 126
Cdd:cd17478 17 ALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLL---GFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 127 IAAGLGCLETAANPFVTVLGPESSGhfrlnLAQTFNSFGAIIAVVFGQSLILsnvphqsqdvldkmspeqlsaykhSLVL 206
Cdd:cd17478 94 AGIGSAAFHPEGARLASQAAGGRRG-----LAMSIFSVGGNLGFALGPLIAA------------------------ALVA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 207 SVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQGSfSASLSRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAV 286
Cdd:cd17478 145 LFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKS-SARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLV 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 287 EEipGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCLISAFAGGHVGLIALTLCSAFMSIQYP 366
Cdd:cd17478 224 QR--GYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFP 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446450748 367 TIFSLGIKNLGQDTKYGSSFIVMTIIG-GGIVTPVMGFVSDAAGNIPTAELIPALCFAVIFIFA 429
Cdd:cd17478 302 VTVVLAQELLPGNVGLASGLMMGLSFGlGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
48-430 |
3.89e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 51.86 E-value: 3.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 48 LLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALfwpAAEIMNYTLFLVGLFII 127
Cdd:cd17475 18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALL---MALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 128 AAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLilsnvphqsqdvldkmspeqlsAYKHSLVLS 207
Cdd:cd17475 95 GAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPL----------------------ALHYGWRAA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 208 vqtpyMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQGSFSASLSRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVE 287
Cdd:cd17475 153 -----FVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 288 EIpGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAP---HKVLAAYALIAMALCLISAFAGGHVGLIALTLCSAFMSIQ 364
Cdd:cd17475 228 HL-GLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGgrrRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLF 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446450748 365 ----YPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVT--PVMGFVSDAAGNIPTAELIPALCFAVIFIFAR 430
Cdd:cd17475 307 aigwNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIgpPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
22-429 |
5.41e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 48.34 E-value: 5.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 22 RSYIIPFALLCSlFFLWAVANNLNdILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLY 101
Cdd:cd17319 1 RWRIIPLLFLAY-VINYLDRVNIS-VAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 102 ALGAALFwpaAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILSNv 181
Cdd:cd17319 79 SLFTALT---GFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 182 phqsqdvldkmspeqlsAYKHSLVLsvqtpyMIIVAIVLLVALLIMLTKFPALqsdnhsdakqgsfsaslsrlarirhwr 261
Cdd:cd17319 155 -----------------GWRWAFII------EGLLGLLLAVLWWFYLRQVWGL--------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 262 waVLAQFCYVGAQTACWSYLIRYAVEE--IPGMTAGF--AANYLTGTMVCFFIGRFTgTWLISRFAPHKVLAAYALIAMA 337
Cdd:cd17319 185 --ALGYFGINYALYGLLTWLPTYLKQArgFSLKQVGLlaAIPFLAGAIGMILGGRLS-DRLLRGARRLVIIIGLLLAAVG 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 338 LCLISAFAGGHVGLIALTLCSAFMSIQYPTIFSLGIKnLGQDTKYGSSFIVMTIIG--GGIVTP-VMGFVSDAAGNiPTA 414
Cdd:cd17319 262 LLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPAD-LLPGEAAATAGGLINSGGnlGGFVAPlLIGYLVDATGS-YTA 339
|
410
....*....|....*
gi 446450748 415 ELIPALCFAVIFIFA 429
Cdd:cd17319 340 AFLFLAAVALLAALL 354
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
27-169 |
7.60e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.80 E-value: 7.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 27 PFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAA 106
Cdd:pfam07690 201 PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAL 280
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446450748 107 LFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIA 169
Cdd:pfam07690 281 GLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
27-168 |
7.94e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.57 E-value: 7.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 27 PFALLCSLFFLWAVANNLNDILLPQF-QQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGA 105
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLYaAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446450748 106 ALFWPAAeimNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAII 168
Cdd:cd17325 280 LLLPLAT---SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVL 339
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
27-228 |
1.50e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 27 PFALLCSLFFLWAVANNLNDILLPQF-QQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGA 105
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVAALLLYYfKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 106 ALFWpAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSF--------GAIIAVVFGQSLI 177
Cdd:COG2211 309 LLLF-FLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIftfaiklgQALAGALAGLLLA 387
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 446450748 178 LSN-VPHQSQdvldkmSPEQLSAYKHSlvlsvqtpYMIIVAIVLLVALLIML 228
Cdd:COG2211 388 LFGyVAGAAQ------SPSALTGIRLL--------FFLLPAVLLLLAALLLL 425
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
47-228 |
3.07e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.01 E-value: 3.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 47 ILLPQFQQ-AFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFWPAAEIMNYTLFLVGLF 125
Cdd:cd17321 189 FLLPLYLQgVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLV 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 126 IIAAGLGCLETAANPFVT-VLGPESSGhfrlnLAQTFNSFGAIIAVVFGQSLILSNVPHQSQDVLDKMSPEQLSAYKHSL 204
Cdd:cd17321 269 LLGLGLGLFATPLTNAALsSVPKEKAG-----AASGILNTARQLGGALGVALLGALLTAGLSANLGDSGVAALLSAAAAA 343
|
170 180
....*....|....*....|....
gi 446450748 205 VLSVQTPYMIIVAIVLLVALLIML 228
Cdd:cd17321 344 FAAGFHLAFLVAAALALLAALLAL 367
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
47-230 |
1.95e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 43.33 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 47 ILLPQF-QQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFWPAAEIMNYTLFLVGLF 125
Cdd:cd17503 199 FLLPLYlQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLF 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 126 IIAAGLGCLETAANP-FVTVLGPESSGHFR--LNLAQTF-NSFGaiIAVVfgqSLILSNVPHQSQDVLDKMSPEQLSayK 201
Cdd:cd17503 279 IRGLGMGLVFMPLNTlALNSLPPEQIGDATalFNTIRQLgGSIG--TALL---ATLLTNRTQFHHSRLSELLAQQVQ--K 351
|
170 180
....*....|....*....|....*....
gi 446450748 202 HSLVLSVQTPYMIIVAIVLLVALLIMLTK 230
Cdd:cd17503 352 QALIIAFNDAFLVSAILLLVGLLLALFLR 380
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
28-363 |
2.19e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.37 E-value: 2.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 28 FALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAAL 107
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 108 FwpAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSL---ILSnvphq 184
Cdd:cd06173 81 L--ALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALgglLVA----- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 185 sqdvldkmspeqlsaykhslVLSVQTPYMIIVAIVLLVALLIMLTKFP-ALQSDNHSDAKQGSFSASLSRLARIRHWRWA 263
Cdd:cd06173 154 --------------------LLGPGGAFAINALSFLLSALLLLFIRRPpPAAPGESSSLLLRDLREGLRYLRRSPLLRLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 264 VLAQFCYVGAQTACWSYLIRYAVEEIPGMTAGFAanYLTGTM-VCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCLIS 342
Cdd:cd06173 214 LLALALFALLGGALTVLLPLLAKEVLGGGAAGYG--LLLAAFgVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVL 291
|
330 340
....*....|....*....|.
gi 446450748 343 AFAGGHVGLIALTLCSAFMSI 363
Cdd:cd06173 292 GLSPSLWLLLAALFLLGLAGG 312
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
30-424 |
3.42e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.55 E-value: 3.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 30 LLCSLFFLwAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFW 109
Cdd:cd17477 1 LLLSVALL-GLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 110 PAAEIMnytLFLVGLFIIAAGLGCLETAANPFVTVLGPESsghfrlNLAQTFNSFGAIIAVVFGQS-LILSNVPHQSqdv 188
Cdd:cd17477 80 LTDSPW---VWFLLRFVMGIGLAGLFVVSESWLNALATNE------NRGRVLGLYSTVLGLGFALGpLLLALVGTAG--- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 189 ldkmspeqlsaykhslvlsvQTPYMIIVAIVLLVALLIMLTKFPALQSDNHsdakqgsfsASLSRLARIRHWRWAVLAQF 268
Cdd:cd17477 148 --------------------ALPFLIAAVLLLLALVPLLLTRRAAPEIEEA---------ESISLRRLLRIAPLALLGAF 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 269 CYVGAQTACWSYLIRYAVEEipGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCLISAFAGGH 348
Cdd:cd17477 199 VAGFLEGAFYSLLPLYGLRL--GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 349 vgLIALTLCSAFMSIQYPTIFSLGIKNLGQD----------TKYGSSFIVMTIIGGGIVTPVMGFVSDAAgnIPTAELIP 418
Cdd:cd17477 277 --PLALLVLLFLWGGAAGPLYTLALALAGDRlpgdelvaanAALLLLYGLGSVIGPLLAGALMDAFGPHG--LFLFLAAV 352
|
....*.
gi 446450748 419 ALCFAV 424
Cdd:cd17477 353 ALLFLL 358
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
62-169 |
1.18e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 41.07 E-value: 1.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 62 QAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALgAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPF 141
Cdd:cd17318 57 TQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITAL-LTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHAL 135
|
90 100
....*....|....*....|....*...
gi 446450748 142 VTVLGPESSGHFRLNLAQTFNSFGAIIA 169
Cdd:cd17318 136 WAKWAPPLERSRLTSIAYSGSQFGTVIA 163
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
39-137 |
1.23e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 40.88 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 39 AVANNLNDILLPQFQQAFTLTnfqaGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFWPAAEIMNYT 118
Cdd:TIGR00894 58 SAENELDNIKNPNFKWSGALQ----GLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIAL 133
|
90
....*....|....*....
gi 446450748 119 LFLVGlFIIAAGLGCLETA 137
Cdd:TIGR00894 134 VVFCR-VIQGLAQGSVSPA 151
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
28-130 |
1.59e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 40.63 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 28 FALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAAL 107
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100
....*....|....*....|...
gi 446450748 108 fwpAAEIMNYTLFLVGLFIIAAG 130
Cdd:cd17474 81 ---CGLSDSFALLLAGRALQGIG 100
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
47-369 |
2.29e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.91 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 47 ILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALfwpAAEIMNYTLFLVGLFI 126
Cdd:cd17328 20 GVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL---SSFAPNFWQLLLFRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 127 IAAGLGCLETAANPFVTVLGPESsghfRLNLAQTFNSF----GAIIAVVFGQSLIlsnvphqsqdvldkmspeqlsaykh 202
Cdd:cd17328 97 VGIGEASYSPIAPTIIADLFPKE----KRTRALGVFYFaiplGSGLGYVVGGLVA------------------------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 203 SLVLSVQTPYMI--IVAIVLLVALLIMLTKFPALQSDNHSDAKQG--SFSASLSRLARIRHWRWAVLAQFCYV---GAQT 275
Cdd:cd17328 148 QATGGWRWAFRVtgVLGVLLAILLLLFVREPPRGAAEGGVMAKSTatSFLADLKALAKNPSFILSTLGFTAVSfvtGALA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 276 ACWSYLIRYAVEEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLiSRFAPHKVLAAYALIamalCLISAFAGGHVGLIALT 355
Cdd:cd17328 228 FWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGIL-ADRLRRKTPRADPLV----CAVGLLAAAPFLFLALV 302
|
330
....*....|....
gi 446450748 356 LCSAFMSIQYPTIF 369
Cdd:cd17328 303 LALSNLLLAWVLLF 316
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
197-427 |
4.32e-03 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 39.14 E-value: 4.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 197 LSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQGSFSAslsrlarirhWRWAVL----AQFCYVG 272
Cdd:PRK03699 150 IAAYLLARSIEWYWVYACIGLVYVAIFILTLFSEFPALGKHAPKADKPVAKEK----------WGIGVLflaiAALLYIL 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 273 AQTACWSYLIRYaVEEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMAL--CLISAFAGGHVG 350
Cdd:PRK03699 220 AQLTFISWVPEY-AQKKFGMSLEDAGNLVSNFWMAYMVGMWIFSFIVRFFDLQRILTVLAGLALVLmyLFVNTDDPSHLL 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 351 LIALTLcSAFMSIQYPTIFSLGIknlgQDTKYGSSFIVMTII----GGGIVTPVMGFVSDAAGNIPTAELIPALCFAVIF 426
Cdd:PRK03699 299 YAILGL-GFFSSAIYTTIITLGS----QQTKVASPKLVNFILtcgtIGTMLTFVVTSPIVAHFGLQAALLTANGLYAVVF 373
|
.
gi 446450748 427 I 427
Cdd:PRK03699 374 V 374
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
212-431 |
9.84e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 37.97 E-value: 9.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 212 YMIIVAIVLLVALLIMLTKFPALQSDNHSdAKQGSFSASLSRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVEEIPG 291
Cdd:cd17332 176 ALIIGIIGIILLLICFFGTRERVVPPEEE-KSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 292 MTAGFaaNYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCLISAFAGGH---VGLIALTLCSAFMSIQYPTI 368
Cdd:cd17332 255 RAELV--LLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGnlvLILVLAVLAGIGYGGANLLP 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450748 369 FSL-------GIKNLGQDTKyGSSFIVMTI---IGGGIVTPVMGFVSDAAGNIPTAE---------------LIPALCFA 423
Cdd:cd17332 333 WAMladvidyGELKTGKRRE-GIFYSVMTFfrkLGLALAGALVGLILSLAGYVANAAaqsasalngirlliaVLPAVLLL 411
|
....*...
gi 446450748 424 VIFIFARF 431
Cdd:cd17332 412 LALILMSF 419
|
|
| |
