|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10133 |
PRK10133 |
L-fucose:H+ symporter permease; |
1-438 |
0e+00 |
|
L-fucose:H+ symporter permease;
Pssm-ID: 182260 [Multi-domain] Cd Length: 438 Bit Score: 796.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 1 MGNTTIQTQSFRAVDAEQSKSKRYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIP 80
Cdd:PRK10133 1 MGNTSIQTQSYRAVDKDAGQSRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 81 AGILMKKLSYKAGIITGLFLYAFGAALFWPAAEIMNYTLFLIGLFIIAAGLGCLETAANPFVTVLGPESGGHFRLNLAQT 160
Cdd:PRK10133 81 AGILMKKLSYKAGIITGLFLYALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 161 FNSFGAIIAVVFGQSLILSNVPHQSQEALDKMTPDQLSAYKHSLVLSVQTPYMIIVAIVLVVALLIMLTKFPALQSDDHS 240
Cdd:PRK10133 161 FNSFGAIIAVVFGQSLILSNVPHQSQDVLDKMTPEQLSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 241 DAKQSSFLSSLSRLIRIRHWRWAVLAQFCYVGAQTACWSYLIRYAIEEIPGMTPGFAANYLTGTMVCFFIGRFTGTWLIS 320
Cdd:PRK10133 241 DAKQGSFSASLSRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVEEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLIS 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 321 RFAPHKVLAAYALFAMLLCLISAFSGGHIGLLALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPV 400
Cdd:PRK10133 321 RFAPHKVLAAYALIAMALCLISAFAGGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPV 400
|
410 420 430
....*....|....*....|....*....|....*...
gi 446450765 401 MGFVSDAAGKIPTAELVPALCFAVIFIFARFRSQAATN 438
Cdd:PRK10133 401 MGFVSDAAGNIPTAELIPALCFAVIFIFARFRSQTATN 438
|
|
| fucP |
TIGR00885 |
L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. ... |
24-429 |
0e+00 |
|
L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. L-fucose(6-deoxy-L-galactose) is a monosaccharide found in glycoproteins and cell wall polysaccharides. L-fucose is used in bacteria through an inducible pathway mediated by atleast four enzymes: a permease, isomerase, kinase and an aldolase which are encoded by fucP, fucI, fucK, fucA respectively. The fuc genes belong to a regulon comprising of four linked operons: fucO, fucA, fucPIK and fucR. The positive regulator is encoded by fucR, whose protein responds to fuculose-1-phosphate, which acts as an effector. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 211614 Cd Length: 408 Bit Score: 554.85 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 24 YIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAF 103
Cdd:TIGR00885 1 YIIPFALITSLFALWGFANDITNPMVPQFQQAFTLTAFQAALVQSAFYGGYFIMAIPAAIFMKKLSYKAGILLGLFLYAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 104 GAALFWPAAEIMNYTLFLIGLFIIAAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFNSFGAIIAVVFGQSLILSNVPH 183
Cdd:TIGR00885 81 GAFLFWPAAEIMNYTLFLVGLFILTAGLGFLETAANPYILVMGPESTATRRLNLAQSFNPFGSIIGMVVAQQLILSNLPH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 184 QSQEALDKMTPDQLSAYKHSLVLSVQTPYMIIVAIVLVVALLIMLTKFPALqsdDHSDAKQSSFLSSLSRLIRIRHWRWA 263
Cdd:TIGR00885 161 QSQDVLDKLSPEELSAIKHSDLASVQTPYMIIGAVVLAVALLIMLTKMPAL---NHSDAKQISFSASLSRLARIRHYREG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 264 VLAQFCYVGAQTACWSYLIRYAIEEIPGMTPGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALFAMLLCLISA 343
Cdd:TIGR00885 238 VIAQFFYVGVQIMCWTFIIQYAVRLIPGMTAGFAANYNIGAMVIFFISRFIGTWLISYLAAHKVLMAYAIIGMALCLGSI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 344 FSGGHIGLLALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVMGFVSD-----AAGKIPTAELVP 418
Cdd:TIGR00885 318 FAGGHVGLYCLTLCSAFMSLMFPTIYGIALKGLGQDTKYGAAGLVMAIIGGGIVPPLQGFIIDmkeiaAAPAVNTSFILP 397
|
410
....*....|.
gi 446450765 419 ALCFAVIFIFA 429
Cdd:TIGR00885 398 LLCFAVIFIYG 408
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
28-431 |
8.12e-153 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 438.96 E-value: 8.12e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 28 FALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGAAL 107
Cdd:cd17394 1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 108 FWPAAEIMNYTLFLIGLFIIAAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFNSFGAIIAVVFGQSLILSNVPHQSqE 187
Cdd:cd17394 81 FIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPSTA-T 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 188 ALDKMTPDQLSAYKHSLVLSVQTPYMIIVAIVLVVALLIMLTKFPALQSDDHSDAKQssfLSSLSRLIRIRHWRWAVLAQ 267
Cdd:cd17394 160 ALAAMSAAELQAYKTAELASVQLPYLGIALVLLLLAVLILLSKLPEIEAAEAEALGS---KGTLLRLLKNPHLRLGVLAI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 268 FCYVGAQTACWSYLIRYAIEEIPGMTPGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALFAMLLCLISAFSGG 347
Cdd:cd17394 237 FFYVGAEVAIWSFLINYLMEYIAGLTETSAATFVSYYWGGFMVGRFLGTALLKKISPKKLLAVFALLGLLLLLGAIFTGG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 348 HIGLLALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVMGFVSDAAGKIPTAELVPALCFAVIFI 427
Cdd:cd17394 317 MVALYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGAVADDAAGLRIAFLVPLLCFAYILF 396
|
....
gi 446450765 428 FARF 431
Cdd:cd17394 397 YGLR 400
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
21-431 |
7.96e-90 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 277.89 E-value: 7.96e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 21 SKRYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFL 100
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 101 YAFGAALFwpaAEIMNYTLFLIGLFIIAAGLGCLETAANPFVTVLGPESGGHfRLNLAQTFNSFGAIIAVVFGQSLILSN 180
Cdd:COG0738 83 MALGLLLF---ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAS-RLNLLHAFFSLGALLGPLLGGLLILLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 181 VPhqsqealdkmtpdqlsaykhslvLSVQTPYMIIVAIVLVVALLIMLTKFPALQSDDHSDAKqssFLSSLSRLIRIRHW 260
Cdd:COG0738 159 LS-----------------------LSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAG---SAASLKSLLKNPRL 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 261 RWAVLAQFCYVGAQTACWSYLIRYAiEEIPGMTPGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALFAMLLCL 340
Cdd:COG0738 213 LLGGLAIFLYVGAEGAIGDWLPLYL-KDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 341 ISAFSGG-HIGLLALTLCSAFMSIQYPTIFSLGIKNLGQDT-KYGSSFIVMTIIGGGIVTPVMGFVSDAAGkIPTAELVP 418
Cdd:COG0738 292 LALLAPGpWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTaAAVSAVLIMGIVGGAIGPPLIGFLADAFG-LRAAFLVP 370
|
410
....*....|...
gi 446450765 419 ALCFAVIFIFARF 431
Cdd:COG0738 371 LVCYLLILLLALA 383
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
31-431 |
1.00e-75 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 240.69 E-value: 1.00e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 31 LCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGAALFWP 110
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 111 AAEIMnytLFLIGLFIIAAGLGCLETAANPFVTVLGPESgGHFRLNLAQTFNSFGAIIAVVFGQSLILSnvphqsqeald 190
Cdd:cd17333 81 TPSIY---LFVVLMFLAGLGAGILDTGANTFVGALFEES-SATRLNVLHGFFGLGALIGPLIATSLLTS----------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 191 kmtpdqlsaykhslVLSVQTPYMIIVAIVLVVALLIMLTKFPALQSDDHSDAKQSSFLSSLSRLIRIRHWRWAVLAQFCY 270
Cdd:cd17333 146 --------------ELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 271 VGAQTACWSYLIRYAIEEiPGMTPGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALFAMLLCLISAFSGG-HI 349
Cdd:cd17333 212 VGAETAFSSWVPSYLVEK-KHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTlVV 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 350 GLLALTLCSAFMSIQYPTIFSLGIKNLG-QDTKYGSSFIVMTIIGGGIVTPVMGFVsDAAGKIPTAELVPALCFAVIFIF 428
Cdd:cd17333 291 GLVATALLGLFMAALFPTILSLGISNLPyAKGKGTSVLLAAGSIGGAIIPFIMGFI-AEAVGIQTAMLLITILYAIIFVL 369
|
...
gi 446450765 429 ARF 431
Cdd:cd17333 370 ALL 372
|
|
| gluP |
TIGR01272 |
glucose/galactose transporter; This model describes the glucose/galactose transporter in ... |
108-428 |
7.09e-41 |
|
glucose/galactose transporter; This model describes the glucose/galactose transporter in bacteria. This belongs to the larger facilitator superfamily. Disruption of the loci leads to the total loss of glucose or galactose uptake in E.coli. Putative transporters in other bacterial species were isolated by functional complementation, which restored it functional activity. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273531 [Multi-domain] Cd Length: 310 Bit Score: 147.73 E-value: 7.09e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 108 FWPAAEIMNYTLFLIGLFIIAAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFNSFGAIIAVVFGQSLILSNVPHQSQE 187
Cdd:TIGR01272 1 FGPAASQRYYVLFLGALFVLASGLTILQVAANPYVSILGPIETAASRLALTQAFNKLGTTVAPLFGGSLILSGAGDLSMQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 188 AldkmtpdqlsAYKHSLVLSVQTPYMIIVAIVLVVALLIMLTKFPALQSDDHSDAKQsSFLSSLSRLIRIRHWRWAVLAQ 267
Cdd:TIGR01272 81 V----------ATANAEAAKVHTPYLLLAGALAVLAIIFAFLPLPELQEADVARVSS-GDTTQKTSAFQFTHLVLGALGI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 268 FCYVGAQTACWSYLIRYAIEE-IPGMTPGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALFAMLLCLISAFSG 346
Cdd:TIGR01272 150 FVYVGAEVSAGSFLVNFLSDPhALGLPEDQAAHFTAYTWGGAMVGRFIGSAVMPMISQGRYLAFNAFLAVLLSIGAALTH 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 347 GHIGLLALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVMGFVSDAAGkIPTAELVPALCFAVIF 426
Cdd:TIGR01272 230 GYVAMWFVLALGLFNSIMFPTIFSLALNALGRHTSQGSGILCLAIVGGAIVPLLQGSLADCLG-IQLAFALPVPCYLYIL 308
|
..
gi 446450765 427 IF 428
Cdd:TIGR01272 309 FY 310
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
31-429 |
2.72e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 103.66 E-value: 2.72e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 31 LCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGAALFWP 110
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 111 AAeimNYTLFLIGLFIIAAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFNSFGAIIAVVFGQSLILsnvphqsqeald 190
Cdd:cd06174 81 AP---SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS------------ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 191 kmtpdqlsaykhSLVLSVQTPYMI--IVAIVLVVALLIMLTKFPALQSDDHSDAKQSSFLSSLSRLIRIRHWRWAVLAQF 268
Cdd:cd06174 146 ------------SLGFGWRAVFLIaaALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIF 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 269 CYVGAQTACWSYLIRYAIEEIpGMTPGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALFAMLLCLISAFSGGH 348
Cdd:cd06174 214 LVNLAYYSFSTLLPLFLLDLG-GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPS 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 349 --IGLLALTLCSAFMSIQYPTIFSLGIKN--LGQDTKYGSSFIVMTIIGGGIVTPVMGFVSDAAGKIPTAELVPALCFAV 424
Cdd:cd06174 293 llLLLLLLLLLGFGLGGLLPLSFALIAELfpPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLL 372
|
....*
gi 446450765 425 IFIFA 429
Cdd:cd06174 373 AAILL 377
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-432 |
4.66e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 82.23 E-value: 4.66e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 20 KSKRYIIPFALLCSLFFLWAVANNLNdILLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLF 99
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLS-VAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 100 LYAFGAALFwpaAEIMNYTLFLIGLFIIAAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFNSFGAIIAVVFGQSLILS 179
Cdd:COG2271 84 LWGLATLLF---GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 180 nvphqsqealdkmtpdqlsaykhslvLSVQTPYMIIVAIVLVVALLIMLtkfpalqsddhsdakqssflsslsrlirirh 259
Cdd:COG2271 161 --------------------------FGWRAAFLILGLPGLLLALLRFW------------------------------- 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 260 wrWAVLAQFCYVGAQTACWSYLIRYAIEEIpGMTPGFAANYLTGTMVCFFIGRFTGTWLISRFAPHK---VLAAYALFAM 336
Cdd:COG2271 184 --LLALAYFLVYFALYGFLTWLPTYLVEVR-GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklvLAIGLLLAAL 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 337 LLCLISAFSGGHIGLLALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTI--IGGGIVTPVMGFVSDAAGKIPTA 414
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFgfLGGALGPLLVGYLLDATGYQAAF 340
|
410
....*....|....*...
gi 446450765 415 ELVPALCFAVIFIFARFR 432
Cdd:COG2271 341 LLLAALALLAALLALLLL 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
18-396 |
1.21e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 80.79 E-value: 1.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 18 QSKSKRYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITG 97
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 98 LFLYAFGAALFWPAaeiMNYTLFLIGLFIIAAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFNSFGAIIAVVFGQSLI 177
Cdd:COG2814 82 LLLFALGSLLCALA---PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 178 LsnvphqsqealdkmtpdqlsaykhslVLSVQTPYMIIVAIVLVVALLIMLTKfpalqsDDHSDAKQSSFLSSLSRLIRI 257
Cdd:COG2814 159 D--------------------------LFGWRWVFLVNAVLALLALLLLLRLL------PESRPAARARLRGSLRELLRR 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 258 RHWRWAVLAQFCYVGAQTACWSYLIRYAIEEIpGMTPGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALFAML 337
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL-GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 338 LCLISAFSGGHIGLL-ALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGI 396
Cdd:COG2814 286 GLLLLALAGSLWLLLlALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
28-432 |
3.96e-13 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 70.68 E-value: 3.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 28 FALLCSLFFLWAVannlndiLLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGAAL 107
Cdd:COG2223 14 FFLAFGVWYLWSV-------LAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 108 FWPAAeimNYTLFLIGLFIIAAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFNSFGAIIAVVFGQSLILSnvphqsqe 187
Cdd:COG2223 87 LALAV---SYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAA-------- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 188 aldkmtpdqlsaykhslvLSVQTPYMIIVAIVLVVALLIMLTKFPAlqsDDHSDAKQSSFLSSLSRLIRIRHWRWAVLAQ 267
Cdd:COG2223 156 ------------------FGWRNAFLILGILLLVVAVLAWLFLRDP---PAGAAAAAKASLRDQLEALRDPRFWLLSLLY 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 268 FCYVGAQTACWSYLIRYAIEEIpGMTPGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALFAMLLCLISAFSGG 347
Cdd:COG2223 215 FGTFGSFIGFSSWLPPYLVDQF-GLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 348 HIGL--LALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTI--IGGGIVTPVMGFVSDAAGKIPTAELVPALCFA 423
Cdd:COG2223 294 SLWLflVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAggLGGFLGPLLFGALLDATGSYTAAFLVFAVLAL 373
|
....*....
gi 446450765 424 VIFIFARFR 432
Cdd:COG2223 374 VALVLTLLL 382
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
30-397 |
3.51e-12 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 67.44 E-value: 3.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 30 LLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGAALFW 109
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 110 PAAeimNYTLFLIGLFIIAAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFNSFGAIIAVVFGQSLILSnvphqsqeal 189
Cdd:pfam07690 81 FAS---SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL---------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 190 dkmtpdqlsaykhslvLSVQTPYMIIVAIVLVVALLIMLTKFPALQSDDHSDAKQSSFLSSLSRLIRIRHWRWAVLAQFC 269
Cdd:pfam07690 148 ----------------FGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 270 YVGAQTACWSYLIRYAieEIPGMTPGFAANYLTGTMVCFFIGRFTGTWLISRFAPHK----VLAAYALFAMLLCLISAFS 345
Cdd:pfam07690 212 FGFAFFGLLTYLPLYQ--EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrlllALLLLILAALGLLLLSLTL 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 446450765 346 GGHIGLLALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIV 397
Cdd:pfam07690 290 SSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGA 341
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
48-429 |
3.67e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 67.57 E-value: 3.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 48 LLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGAALFWPAAeimNYTLFLIGLFII 127
Cdd:cd17324 21 LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP---SFALLLLARALA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 128 AAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFNSFGAIIAVVFGQSLilsnvphqsqealdkmtpdqlsaykhSLVLS 207
Cdd:cd17324 98 GLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL--------------------------GQLLG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 208 VQTPYMIIVAIVLVVALLIMLTkfpaLQSDDHSDAKQSSFLSSLSRLIRIRHWRWAVLAQFCYVGAQTACWSYlIRYAIE 287
Cdd:cd17324 152 WRAAFLAIAVLALLAALLLWRL----LPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTY-LAPFLT 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 288 EIPGMTPGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALFAMLLCLISAFSGGHIGLLALT-LCSAFMSIQYP 366
Cdd:cd17324 227 DVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLvLWGLGFFAAHS 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446450765 367 TIFSLGIKNLGQDTKYGSSFIVMTI-IGGGIVTPVMGFVSDAAGKIPTAELVPALCFAVIFIFA 429
Cdd:cd17324 307 ALQTRVLRLAPEARGLASSLYLAAYnLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
48-432 |
2.91e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 64.52 E-value: 2.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 48 LLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGAALFwpaAEIMNYTLFLIGLFII 127
Cdd:cd17325 18 ILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF---AFATSYWQLLLARFLQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 128 AAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFNSFGAIIAVVFGQSLIlsnvphqsqealdkmtpdqlsaykhsLVLS 207
Cdd:cd17325 95 GLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA--------------------------DALG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 208 VQTPYmIIVAIVLVVALLIMLTKFPALQSDDHSDAKQSSFLSSLSRLIRIRHWRWAV-LAQFCYVGAQTACWSYLIRYAI 286
Cdd:cd17325 149 YRAPF-LVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALfLAIFVLAFAFGALEPFLPLYAA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 287 EEIpGMTPGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALFAMLLCLISAFSGGHIGLLALT-LCSAFMSIQY 365
Cdd:cd17325 228 ELG-GLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLaLLGLGLGLVF 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 366 PTIFSLGIKNLGQDtKYGSSF-IVMTIIGGGIVT--PVMGFVSDAAGKIPTAELVPALCFAVIFIFARFR 432
Cdd:cd17325 307 PATLALLADIVPPE-GRGTAMgLFNTAFSLGMVLgpLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
94-431 |
3.83e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 55.29 E-value: 3.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 94 IITGLFLYAFGAALFW---PAAEIMNYTLFLIGLFIIAAGLGCLETAANPFVTVLGPESGGHFRLN-LAQTFNSFGAIIA 169
Cdd:COG2211 84 ILIGAIPLALSFVLLFtapDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSsWRFAFAGLGGLLA 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 170 VVFGQSLIlsnvphqsqealDKMTPDQLSAYkhslvlsvqTPYMIIVAIVLVVALLIMltkFPALQSDDHSDAKQSSFLS 249
Cdd:COG2211 164 SVLPPPLV------------AAFGGDAALGY---------RLTALIFAVLGLLAFLLT---FFGTKERPVPEEEKVSLKE 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 250 SLSRLIRIRHWRWAVLAQFCYVGAQTACWSYLIRYAIEEIpGMTPGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLA 329
Cdd:COG2211 220 SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL-GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFI 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 330 AYALFAMLLCLISAFSGGH---IGLLALTLCSAFMSIQYPTIFSL-------GIKNLGQDT--KYGSSFIVMTIIGGGIV 397
Cdd:COG2211 299 IGLLLAALGLLLLFFLGPGnlwLLLVLAALAGIGLGAILVLPWAMladvvdyDEWKTGRRRegLYFGIFTFAIKLGQALA 378
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 446450765 398 TPVMGFVSDAAGKIPTAE--------------LVPALCFAVIFIFARF 431
Cdd:COG2211 379 GALAGLLLALFGYVAGAAqspsaltgirllffLLPAVLLLLAALLLLF 426
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
28-431 |
8.67e-08 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 53.80 E-value: 8.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 28 FALLCSLFFLWAVannlndiLLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKL-SYKAGIITGLFLYAFGAA 106
Cdd:cd17393 8 FFINGILMASWAT-------RIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFgSRRVTRLGALLLLLALLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 107 LFWPAaeimNYTLFLIGLFIIAAGLGCLETAANPFVTVLGPESGGHFrLNLAQTFNSFGAIIAVVFGQSLILSNVPhqsq 186
Cdd:cd17393 81 LGLAP----SVPALALALFLFGAANGALDVAMNAQGVAVERAYGRPI-MSSLHAMWSLGGLAGALLGAAAIGAGVS---- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 187 ealdkmtpdqlsaykhslvlsvQTPYMIIVAIVLVVALLIMLTKFPALQSDDHSDAKQSSFLSSLSRLiRIRHWRWAVLA 266
Cdd:cd17393 152 ----------------------PGVHLLAAAVLLLLAALVAIRALLPGTGEAAEDRPDGAGKPGFLLP-NRLLLLLGLLA 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 267 QFCYVGAQTAC-WSYLIryaIEEIPGMTPGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALFAMLLCLISAFS 345
Cdd:cd17393 209 LAAALAEGAAAdWSALY---LRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLA 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 346 GGHIGLLALTLCSAF-MSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTP-VMGFVSDAAGkIPTAELVPALCFA 423
Cdd:cd17393 286 PSVWVALAGFALMGLgLSVVVPLAFSAAGALPGLAAGIAVARVATLGYLGFLVGPpLIGFLADATG-LRTAFLVVALLAL 364
|
....*...
gi 446450765 424 VIFIFARF 431
Cdd:cd17393 365 LVALLARA 372
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
47-429 |
8.35e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.63 E-value: 8.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 47 ILLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGAALFwpaAEIMNYTLFLIGLFI 126
Cdd:cd17478 17 ALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLL---GFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 127 IAAGLGCLETAANPFVTVLGPESGGhfrlnLAQTFNSFGAIIAVVFGQSLILsnvphqsqealdkmtpdqlsaykhSLVL 206
Cdd:cd17478 94 AGIGSAAFHPEGARLASQAAGGRRG-----LAMSIFSVGGNLGFALGPLIAA------------------------ALVA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 207 SVQTPYMIIVAIVLVVALLIMLTKFPALQSDDHSDAKQSSFLSSLSRLIRiRHWRWAVLAQFCYVGAQTACWSYLIRYAI 286
Cdd:cd17478 145 LFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVW-RALLLLLIIVFLRSWVLSSLTTFLPFYLV 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 287 EEipGMTPGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALFAMLLCLISAFSGGHIGLLALTLCSAFMSIQYP 366
Cdd:cd17478 224 QR--GYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFP 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446450765 367 TIFSLGIKNLGQDTKYGSSFIVMTIIG-GGIVTPVMGFVSDAAGKIPTAELVPALCFAVIFIFA 429
Cdd:cd17478 302 VTVVLAQELLPGNVGLASGLMMGLSFGlGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
27-168 |
4.97e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 48.34 E-value: 4.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 27 PFALLCSLFFLWAVANNLNDILLPQF-QQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGA 105
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLYaAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446450765 106 ALFWPAAeimNYTLFLIGLFIIAAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFNSFGAII 168
Cdd:cd17325 280 LLLPLAT---SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVL 339
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
48-432 |
6.87e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 47.95 E-value: 6.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 48 LLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGAALFWPAAeimNYTLFLIGLFII 127
Cdd:COG2807 40 LLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP---SVALLLAGTALI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 128 AAGLGCLETAANPFVTVLGPESGGhFRLNLAQTFNSFGAIIAVVFGQSLILSnvphqsqealdkmtpdqlsaykhslvLS 207
Cdd:COG2807 117 GAGIAVGNVLLPGLIKRWFPDRVG-LMTGLYTAAMGLGAALAAGLTVPLAAA--------------------------LG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 208 VQTPYMIIVAIVLVVALLIMLtkfpaLQSDDHSDAKQSSFLSSLSRLIRIRHWRWAVLAQFCYVGAQTACWSYLIRYAIE 287
Cdd:COG2807 170 WRGALAVWALLALLALLLWLP-----LLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 288 EipGMTPGFAANYLTGTMVCFFIGRFTGTWLISRFAPHK-VLAAYALFAMLLCLISAFSGGHIGLLALTLCSAFMSIQYP 366
Cdd:COG2807 245 A--GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRpLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFP 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446450765 367 TIFSLGIKNLGQDTKYG--SSFIVMT-IIGGGIVTPVMGFVSDAAGKiPTAELVPALCFAVIFIFARFR 432
Cdd:COG2807 323 LALTLIGLRARTPAEAAalSGMAQSVgYLLAALGPLLVGALHDATGS-WTAALLLLAALAVLMLVAGLL 390
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
35-431 |
8.86e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.59 E-value: 8.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 35 FFLWAVANNLNdILLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGAALFWPAAEI 114
Cdd:cd17489 6 FFFFLSFYLLL-PVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 115 mnyTLFLIGLFIIAAGLGCLETAANPFVTVLGPESgghfRLNLAQTFNSFGAIIAVVFGQSLILSNVPHqsqealdkmtp 194
Cdd:cd17489 85 ---ALLLVLRLIHGIGWGAFTTAAATLVADIIPPS----RRGEGIGYYGLATTLAMALGPALGLFLYQH----------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 195 dqlsaykhslvLSVQTPYMIIVAIVLVVALLIMLTKFPAlqsddHSDAKQSSFLSSLSRLIRIRHWRWAVLAQFCYVGAQ 274
Cdd:cd17489 147 -----------LGFAVLFIVAAVLALLALLLVFLVKDPP-----PVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAY 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 275 TACWSYLIRYAIEEIPGMtpgfAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALFAML-LCLISAFSGGHIGLLA 353
Cdd:cd17489 211 GAISTFLPLYAAERGISN----AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALgLLLLSFAGSPWMLLLA 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 354 LTLCSAFMSIQYPTIFSLGIKNLGQdTKYGSSFIVMTI---IGGGIVTPVMGFVSDAAGkIPTAELVPALCFAVIFIFAR 430
Cdd:cd17489 287 AVLYGLGFGLLFPALQALAVDLVPP-HRRGAANGTFFIffdLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYI 364
|
.
gi 446450765 431 F 431
Cdd:cd17489 365 F 365
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
27-169 |
1.40e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.03 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 27 PFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGAA 106
Cdd:pfam07690 201 PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAL 280
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446450765 107 LFWPAAEIMNYTLFLIGLFIIAAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFNSFGAIIA 169
Cdd:pfam07690 281 GLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
48-430 |
3.37e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 45.69 E-value: 3.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 48 LLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLyafGAALFWPAAEIMNYTLFLIGLFII 127
Cdd:cd17475 18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLL---MGAAALLMALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 128 AAGLGCLETAANPFVTVLGPESGGHFRLNLAQTFNSFGAIIAVVFGQSLilsnvphqsqealdkmtpdqlsAYKHSLVLS 207
Cdd:cd17475 95 GAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPL----------------------ALHYGWRAA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 208 vqtpyMIIVAIVLVVALLIMLTKFPALQSDDHSDAKQSSFLSSLSRLIRIRHWRWAVLAQFCYVGAQTACWSYLIRYAIE 287
Cdd:cd17475 153 -----FVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 288 EIpGMTPGFAANYLTGTMVCFFIGRFTGTWLISRFAP---HKVLAAYALFAMLLCLISAFSGGHIGLLALTLCSAFMSIQ 364
Cdd:cd17475 228 HL-GLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGgrrRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLF 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446450765 365 ----YPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVT--PVMGFVSDAAGKIPTAELVPALCFAVIFIFAR 430
Cdd:cd17475 307 aigwNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIgpPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
47-230 |
3.44e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 45.63 E-value: 3.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 47 ILLPQFQQ-AFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGAALFWPAAEIMNYTLFLIGLF 125
Cdd:cd17321 189 FLLPLYLQgVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLV 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 126 IIAAGLGCLETAANPFVT-VLGPE-----SGghfrlnLAQTFNSFGAIIAVVFGQSLILSNVPHQSQEALDKMTPDQLSA 199
Cdd:cd17321 269 LLGLGLGLFATPLTNAALsSVPKEkagaaSG------ILNTARQLGGALGVALLGALLTAGLSANLGDSGVAALLSAAAA 342
|
170 180 190
....*....|....*....|....*....|.
gi 446450765 200 ykhSLVLSVQTPYMIIVAIVLVVALLIMLTK 230
Cdd:cd17321 343 ---AFAAGFHLAFLVAAALALLAALLALLLP 370
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
47-230 |
1.80e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 43.33 E-value: 1.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 47 ILLPQF-QQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGAALFWPAAEIMNYTLFLIGLF 125
Cdd:cd17503 199 FLLPLYlQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLF 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 126 IIAAGLGCLETAANP-FVTVLGPESGGHFR--LNLAQTF-NSFGaiIAVVfgqSLILSNVPHQSQEALDKMTPDQLSayK 201
Cdd:cd17503 279 IRGLGMGLVFMPLNTlALNSLPPEQIGDATalFNTIRQLgGSIG--TALL---ATLLTNRTQFHHSRLSELLAQQVQ--K 351
|
170 180
....*....|....*....|....*....
gi 446450765 202 HSLVLSVQTPYMIIVAIVLVVALLIMLTK 230
Cdd:cd17503 352 QALIIAFNDAFLVSAILLLVGLLLALFLR 380
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
47-130 |
2.64e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.94 E-value: 2.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 47 ILLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGAALFwpaAEIMNYTLFLIGLFI 126
Cdd:cd17319 24 VAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALT---GFATSLTSLYVLRFL 100
|
....
gi 446450765 127 IAAG 130
Cdd:cd17319 101 LGVA 104
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
28-130 |
1.59e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 40.63 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 28 FALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGAAL 107
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100
....*....|....*....|...
gi 446450765 108 fwpAAEIMNYTLFLIGLFIIAAG 130
Cdd:cd17474 81 ---CGLSDSFALLLAGRALQGIG 100
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
62-169 |
4.48e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 39.14 E-value: 4.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446450765 62 QAGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFgAALFWPAAEIMNYTLFLIGLFIIAAGLGCLETAANPF 141
Cdd:cd17318 57 TQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITAL-LTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHAL 135
|
90 100
....*....|....*....|....*...
gi 446450765 142 VTVLGPESGGHFRLNLAQTFNSFGAIIA 169
Cdd:cd17318 136 WAKWAPPLERSRLTSIAYSGSQFGTVIA 163
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
39-112 |
7.60e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 38.57 E-value: 7.60e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446450765 39 AVANNLNDILLPQFQQAFTLTnfqaGLIQSAFYFGYFVIPIPAGILMKKLSYKAGIITGLFLYAFGAALFWPAA 112
Cdd:TIGR00894 58 SAENELDNIKNPNFKWSGALQ----GLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAA 127
|
|
| |
