Ger(x)C family spore germination protein similar to Bacillus anthracis spore germination protein XC that may allow B.anthracis to germinate within phagocytic cells and is therefore involved in virulence
Spore germination B3/ GerAC like, C-terminal; The GerAC protein of the Bacillus subtilis spore ...
2-187
2.15e-19
Spore germination B3/ GerAC like, C-terminal; The GerAC protein of the Bacillus subtilis spore is required for the germination response to L-alanine. Members of this family are thought to be located in the inner spore membrane. Although the function of this family is unclear, they are likely to encode the components of the germination apparatus that respond directly to this germinant, mediating the spore's response.
The actual alignment was detected with superfamily member COG5903:
Pssm-ID: 473253 Cd Length: 369 Bit Score: 84.18 E-value: 2.15e-19
germination protein, Ger(x)C family; Members of this protein family are restricted to ...
1-191
2.27e-19
germination protein, Ger(x)C family; Members of this protein family are restricted to endospore-forming members of the Firmicutes lineage of bacteria, including the genera Bacillus, Clostridium, Thermoanaerobacter, Carboxydothermus, etc. Members are nearly all predicted lipoproteins and belong to probable transport operons, some of which have been characterized as crucial to germination in response to alanine. Members typically have been gene symbols gerKC, gerAC, gerYC, etc. [Transport and binding proteins, Amino acids, peptides and amines, Cellular processes, Sporulation and germination]
Pssm-ID: 274338 Cd Length: 371 Bit Score: 84.22 E-value: 2.27e-19
Spore germination B3/ GerAC like, C-terminal; The GerAC protein of the Bacillus subtilis spore ...
30-188
5.92e-15
Spore germination B3/ GerAC like, C-terminal; The GerAC protein of the Bacillus subtilis spore is required for the germination response to L-alanine. Members of this family are thought to be located in the inner spore membrane. Although the function of this family is unclear, they are likely to encode the components of the germination apparatus that respond directly to this germinant, mediating the spore's response.
Pssm-ID: 428498 Cd Length: 167 Bit Score: 69.26 E-value: 5.92e-15
germination protein, Ger(x)C family; Members of this protein family are restricted to ...
1-191
2.27e-19
germination protein, Ger(x)C family; Members of this protein family are restricted to endospore-forming members of the Firmicutes lineage of bacteria, including the genera Bacillus, Clostridium, Thermoanaerobacter, Carboxydothermus, etc. Members are nearly all predicted lipoproteins and belong to probable transport operons, some of which have been characterized as crucial to germination in response to alanine. Members typically have been gene symbols gerKC, gerAC, gerYC, etc. [Transport and binding proteins, Amino acids, peptides and amines, Cellular processes, Sporulation and germination]
Pssm-ID: 274338 Cd Length: 371 Bit Score: 84.22 E-value: 2.27e-19
Spore germination B3/ GerAC like, C-terminal; The GerAC protein of the Bacillus subtilis spore ...
30-188
5.92e-15
Spore germination B3/ GerAC like, C-terminal; The GerAC protein of the Bacillus subtilis spore is required for the germination response to L-alanine. Members of this family are thought to be located in the inner spore membrane. Although the function of this family is unclear, they are likely to encode the components of the germination apparatus that respond directly to this germinant, mediating the spore's response.
Pssm-ID: 428498 Cd Length: 167 Bit Score: 69.26 E-value: 5.92e-15
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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