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Conserved domains on  [gi|446457379|ref|WP_000535233|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Bacillus]

Protein Classification

HTH_36 and HTH domain-containing protein( domain architecture ID 10617572)

HTH_36 and HTH domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_36 pfam13730
Helix-turn-helix domain;
34-92 8.84e-09

Helix-turn-helix domain;


:

Pssm-ID: 463970 [Multi-domain]  Cd Length: 55  Bit Score: 50.57  E-value: 8.84e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446457379   34 QLNKTDATIIHFLGKYAVNEkqktvGVACPLMETIATNVGKSIRTVRRSIAKLEELGII 92
Cdd:pfam13730   2 RLSPTAKLLLLILASYANKD-----GGCFPSVETLAKRLGLSRRTIQRAIKELEELGYL 55
COG3355 super family cl47318
Predicted transcriptional regulator [Transcription];
8-126 4.62e-07

Predicted transcriptional regulator [Transcription];


The actual alignment was detected with superfamily member COG3355:

Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 48.04  E-value: 4.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446457379   8 MKPYSEFQSKEEFNIyqKQVLKYYrFQLNKTDATIIHFLgkyAVNEKQKTVgvacplmETIATNVGKSIRTVRRSIAKLE 87
Cdd:COG3355    1 MSDSIEMLVRLEPDL--EDVLECV-YGLSETDAEVYLIL---LENGEPLTV-------EELAEALDRSRSTVYRSLQKLL 67

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446457379  88 ELGIIKRvaTKERHKRGGYSanlYIFLISAIDRMDDRMK 126
Cdd:COG3355   68 EAGLVER--EKRNLEGGGYP---YVYYAIDPEELKEKLV 101
 
Name Accession Description Interval E-value
HTH_36 pfam13730
Helix-turn-helix domain;
34-92 8.84e-09

Helix-turn-helix domain;


Pssm-ID: 463970 [Multi-domain]  Cd Length: 55  Bit Score: 50.57  E-value: 8.84e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446457379   34 QLNKTDATIIHFLGKYAVNEkqktvGVACPLMETIATNVGKSIRTVRRSIAKLEELGII 92
Cdd:pfam13730   2 RLSPTAKLLLLILASYANKD-----GGCFPSVETLAKRLGLSRRTIQRAIKELEELGYL 55
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
8-126 4.62e-07

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 48.04  E-value: 4.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446457379   8 MKPYSEFQSKEEFNIyqKQVLKYYrFQLNKTDATIIHFLgkyAVNEKQKTVgvacplmETIATNVGKSIRTVRRSIAKLE 87
Cdd:COG3355    1 MSDSIEMLVRLEPDL--EDVLECV-YGLSETDAEVYLIL---LENGEPLTV-------EELAEALDRSRSTVYRSLQKLL 67

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446457379  88 ELGIIKRvaTKERHKRGGYSanlYIFLISAIDRMDDRMK 126
Cdd:COG3355   68 EAGLVER--EKRNLEGGGYP---YVYYAIDPEELKEKLV 101
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
68-114 9.47e-04

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 38.61  E-value: 9.47e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 446457379  68 IATNVGKSIRTVRRSIAKLEELGIIKRVATKERHKRGGYSANLYIFL 114
Cdd:COG1522   25 LAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEV 71
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 68-123 4.97e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.35  E-value: 4.97e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446457379  68 IATNVGKSIRTVRRSIAKLEELGIIKRvatKERHKRGGYSANLYIFLISAIDRMDD 123
Cdd:cd00090   26 LAERLGLSQSTVSRHLKKLEEAGLVES---RREGRRVYYSLTDAERLLALLESLLE 78
 
Name Accession Description Interval E-value
HTH_36 pfam13730
Helix-turn-helix domain;
34-92 8.84e-09

Helix-turn-helix domain;


Pssm-ID: 463970 [Multi-domain]  Cd Length: 55  Bit Score: 50.57  E-value: 8.84e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446457379   34 QLNKTDATIIHFLGKYAVNEkqktvGVACPLMETIATNVGKSIRTVRRSIAKLEELGII 92
Cdd:pfam13730   2 RLSPTAKLLLLILASYANKD-----GGCFPSVETLAKRLGLSRRTIQRAIKELEELGYL 55
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
8-126 4.62e-07

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 48.04  E-value: 4.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446457379   8 MKPYSEFQSKEEFNIyqKQVLKYYrFQLNKTDATIIHFLgkyAVNEKQKTVgvacplmETIATNVGKSIRTVRRSIAKLE 87
Cdd:COG3355    1 MSDSIEMLVRLEPDL--EDVLECV-YGLSETDAEVYLIL---LENGEPLTV-------EELAEALDRSRSTVYRSLQKLL 67

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446457379  88 ELGIIKRvaTKERHKRGGYSanlYIFLISAIDRMDDRMK 126
Cdd:COG3355   68 EAGLVER--EKRNLEGGGYP---YVYYAIDPEELKEKLV 101
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
68-114 9.47e-04

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 38.61  E-value: 9.47e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 446457379  68 IATNVGKSIRTVRRSIAKLEELGIIKRVATKERHKRGGYSANLYIFL 114
Cdd:COG1522   25 LAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEV 71
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 68-123 4.97e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.35  E-value: 4.97e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446457379  68 IATNVGKSIRTVRRSIAKLEELGIIKRvatKERHKRGGYSANLYIFLISAIDRMDD 123
Cdd:cd00090   26 LAERLGLSQSTVSRHLKKLEEAGLVES---RREGRRVYYSLTDAERLLALLESLLE 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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