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Conserved domains on  [gi|446458298|ref|WP_000536152|]
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MULTISPECIES: hypothetical protein [Bacillus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BclA_C super family cl47267
BclA C-terminal domain; This is the C-terminal domain of BclA (Bacillus collagen-like protein ...
 50-182 1.98e-05

BclA C-terminal domain; This is the C-terminal domain of BclA (Bacillus collagen-like protein of anthracis) which is expressed on spores of Bacillus species. Trimers of the C-terminal domain (CTD) form the tips of the spore's hair-like nap and are the immunodominant target of vertebrate antibodies and drive trimerization. Structure analysis indicate the C-terminal region of the peptide folding into an all-beta structure with a jelly-fold topology, similar to the first human complement C1q, a member of the tumor necrosis factor (TNF)-like family. The C-terminal globular domain has been shown to be located on the exterior of the exosporium, and therefore is critical in determining the immunogenicity of the spore in a mammalian host.


The actual alignment was detected with superfamily member pfam18573:

Pssm-ID: 436587 [Multi-domain]  Cd Length: 127  Bit Score: 42.26  E-value: 1.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458298   50 VPFGDPFPFNHVGPLAGGVSLLNPTTIHFRQAGDYRVSFIssINTTLNPVFphipVITIFLNNNPLANSQGDFAIQMNTs 129
Cdd:pfam18573  13 VLGGTPVPLPNNQNLSGITVNGTNTTFTVNEAGRYYISYQ--VNTTAALLV----GLRLLVNGTPVPGSIITPALSTSS- 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 446458298  130 snneclqLVGETIVTVPANSTLQLRNnsgFNRQSIVTCDNGINSiELTVTKLS 182
Cdd:pfam18573  86 -------YSNSVIVTLTAGDTISLQL---FGLAGAATLGGGTGA-SLTIIRLA 127
 
Name Accession Description Interval E-value
BclA_C pfam18573
BclA C-terminal domain; This is the C-terminal domain of BclA (Bacillus collagen-like protein ...
 50-182 1.98e-05

BclA C-terminal domain; This is the C-terminal domain of BclA (Bacillus collagen-like protein of anthracis) which is expressed on spores of Bacillus species. Trimers of the C-terminal domain (CTD) form the tips of the spore's hair-like nap and are the immunodominant target of vertebrate antibodies and drive trimerization. Structure analysis indicate the C-terminal region of the peptide folding into an all-beta structure with a jelly-fold topology, similar to the first human complement C1q, a member of the tumor necrosis factor (TNF)-like family. The C-terminal globular domain has been shown to be located on the exterior of the exosporium, and therefore is critical in determining the immunogenicity of the spore in a mammalian host.


Pssm-ID: 436587 [Multi-domain]  Cd Length: 127  Bit Score: 42.26  E-value: 1.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458298   50 VPFGDPFPFNHVGPLAGGVSLLNPTTIHFRQAGDYRVSFIssINTTLNPVFphipVITIFLNNNPLANSQGDFAIQMNTs 129
Cdd:pfam18573  13 VLGGTPVPLPNNQNLSGITVNGTNTTFTVNEAGRYYISYQ--VNTTAALLV----GLRLLVNGTPVPGSIITPALSTSS- 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 446458298  130 snneclqLVGETIVTVPANSTLQLRNnsgFNRQSIVTCDNGINSiELTVTKLS 182
Cdd:pfam18573  86 -------YSNSVIVTLTAGDTISLQL---FGLAGAATLGGGTGA-SLTIIRLA 127
 
Name Accession Description Interval E-value
BclA_C pfam18573
BclA C-terminal domain; This is the C-terminal domain of BclA (Bacillus collagen-like protein ...
 50-182 1.98e-05

BclA C-terminal domain; This is the C-terminal domain of BclA (Bacillus collagen-like protein of anthracis) which is expressed on spores of Bacillus species. Trimers of the C-terminal domain (CTD) form the tips of the spore's hair-like nap and are the immunodominant target of vertebrate antibodies and drive trimerization. Structure analysis indicate the C-terminal region of the peptide folding into an all-beta structure with a jelly-fold topology, similar to the first human complement C1q, a member of the tumor necrosis factor (TNF)-like family. The C-terminal globular domain has been shown to be located on the exterior of the exosporium, and therefore is critical in determining the immunogenicity of the spore in a mammalian host.


Pssm-ID: 436587 [Multi-domain]  Cd Length: 127  Bit Score: 42.26  E-value: 1.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458298   50 VPFGDPFPFNHVGPLAGGVSLLNPTTIHFRQAGDYRVSFIssINTTLNPVFphipVITIFLNNNPLANSQGDFAIQMNTs 129
Cdd:pfam18573  13 VLGGTPVPLPNNQNLSGITVNGTNTTFTVNEAGRYYISYQ--VNTTAALLV----GLRLLVNGTPVPGSIITPALSTSS- 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 446458298  130 snneclqLVGETIVTVPANSTLQLRNnsgFNRQSIVTCDNGINSiELTVTKLS 182
Cdd:pfam18573  86 -------YSNSVIVTLTAGDTISLQL---FGLAGAATLGGGTGA-SLTIIRLA 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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