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Conserved domains on  [gi|446458469|ref|WP_000536323|]
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MULTISPECIES: class I SAM-dependent methyltransferase [Bacillus]

Protein Classification

class I SAM-dependent DNA methyltransferase( domain architecture ID 11471966)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047
PubMed:  23180741|12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
8-195 1.50e-22

Predicted methyltransferase, contains TPR repeat [General function prediction only];


:

Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 90.06  E-value: 1.50e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469   8 LFDEWAHTYDSFVqGEDIQYKEVFAHYEDILEDVVNKSFGNVLEFGVGTGNLTNKLLLAGRTVYGIEPSREMRMIAKEKl 87
Cdd:COG4976   10 LFDQYADSYDAAL-VEDLGYEAPALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREK- 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469  88 PKEFSITEGDFLSFEVP-NSIDTIVSTYAFHHLTDDEKnvAVAKYSQLLNKGGKIVFadtifadqdaydkTVETAKQRGF 166
Cdd:COG4976   88 GVYDRLLVADLADLAEPdGRFDLIVAADVLTYLGDLAA--VFAGVARALKPGGLFIF-------------SVEDADGSGR 152

                        170       180
                 ....*....|....*....|....*....
gi 446458469 167 HQLANDlqteYYtripvmQTIFENNGFHV 195
Cdd:COG4976  153 YAHSLD----YV------RDLLAAAGFEV 171
 
Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
8-195 1.50e-22

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 90.06  E-value: 1.50e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469   8 LFDEWAHTYDSFVqGEDIQYKEVFAHYEDILEDVVNKSFGNVLEFGVGTGNLTNKLLLAGRTVYGIEPSREMRMIAKEKl 87
Cdd:COG4976   10 LFDQYADSYDAAL-VEDLGYEAPALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREK- 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469  88 PKEFSITEGDFLSFEVP-NSIDTIVSTYAFHHLTDDEKnvAVAKYSQLLNKGGKIVFadtifadqdaydkTVETAKQRGF 166
Cdd:COG4976   88 GVYDRLLVADLADLAEPdGRFDLIVAADVLTYLGDLAA--VFAGVARALKPGGLFIF-------------SVEDADGSGR 152

                        170       180
                 ....*....|....*....|....*....
gi 446458469 167 HQLANDlqteYYtripvmQTIFENNGFHV 195
Cdd:COG4976  153 YAHSLD----YV------RDLLAAAGFEV 171
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 49-139 7.22e-18

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 75.29  E-value: 7.22e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469   49 VLEFGVGTGNLTNKLL-LAGRTVYGIEPSREMRMIAKEKLPKE---FSITEGDFLSFEVP-NSIDTIVSTYAFHHLTDDE 123
Cdd:pfam13649   1 VLDLGCGTGRLTLALArRGGARVTGVDLSPEMLERARERAAEAglnVEFVQGDAEDLPFPdGSFDLVVSSGVLHHLPDPD 80

                          90
                  ....*....|....*.
gi 446458469  124 KNVAVAKYSQLLNKGG 139
Cdd:pfam13649  81 LEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 48-148 2.52e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.51  E-value: 2.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469  48 NVLEFGVGTGNLTNKLLLA-GRTVYGIEPSREMRMIAKE----KLPKEFSITEGDF--LSFEVPNSIDTIVSTYAFHHLT 120
Cdd:cd02440    1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELARKaaaaLLADNVEVLKGDAeeLPPEADESFDVIISDPPLHHLV 80

                         90       100
                 ....*....|....*....|....*...
gi 446458469 121 DDEKNVaVAKYSQLLNKGGKIVFADTIF 148
Cdd:cd02440   81 EDLARF-LEEARRLLKPGGVLVLTLVLA 107
PRK08317 PRK08317
hypothetical protein; Provisional
 49-146 1.73e-08

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 53.02  E-value: 1.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469  49 VLEFGVGTGNLTnkLLLAGRT-----VYGIEPSREMRMIAKEK-----LPKEFSITEGDFLSFEvPNSIDTIVSTYAFHH 118
Cdd:PRK08317  23 VLDVGCGPGNDA--RELARRVgpegrVVGIDRSEAMLALAKERaaglgPNVEFVRGDADGLPFP-DGSFDAVRSDRVLQH 99

                         90       100
                 ....*....|....*....|....*...
gi 446458469 119 LTDDEKnvAVAKYSQLLNKGGKIVFADT 146
Cdd:PRK08317 100 LEDPAR--ALAEIARVLRPGGRVVVLDT 125
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 13-151 8.67e-08

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 50.75  E-value: 8.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469   13 AHTYDSFVqgeDIQyKEVFAHYEDILEDVVNKSFGNVLEFGVGTGNLTNKLLLAGRTVYGI--EPSREMRMIAKEKLPKE 90
Cdd:TIGR02072   6 AKTYDRHA---KIQ-REMAKRLLALLKEKGIFIPASVLDIGCGTGYLTRALLKRFPQAEFIalDISAGMLAQAKTKLSEN 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446458469   91 FSITEGDF--LSFEvPNSIDTIVSTYAFHHLTDdeKNVAVAKYSQLLNKGGkiVFADTIFADQ 151
Cdd:TIGR02072  82 VQFICGDAekLPLE-DSSFDLIVSNLALQWCDD--LSQALSELARVLKPGG--LLAFSTFGPG 139
rADc smart00650
Ribosomal RNA adenine dimethylases;
48-112 5.12e-07

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 47.89  E-value: 5.12e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446458469    48 NVLEFGVGTGNLTNKLLLAGRTVYGIEPSREMRMIAKEKLPKEFSIT--EGDFLSFEVP-NSIDTIVS 112
Cdd:smart00650  16 TVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFAAADNLTviHGDALKFDLPkLQPYKVVG 83
 
Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
8-195 1.50e-22

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 90.06  E-value: 1.50e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469   8 LFDEWAHTYDSFVqGEDIQYKEVFAHYEDILEDVVNKSFGNVLEFGVGTGNLTNKLLLAGRTVYGIEPSREMRMIAKEKl 87
Cdd:COG4976   10 LFDQYADSYDAAL-VEDLGYEAPALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREK- 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469  88 PKEFSITEGDFLSFEVP-NSIDTIVSTYAFHHLTDDEKnvAVAKYSQLLNKGGKIVFadtifadqdaydkTVETAKQRGF 166
Cdd:COG4976   88 GVYDRLLVADLADLAEPdGRFDLIVAADVLTYLGDLAA--VFAGVARALKPGGLFIF-------------SVEDADGSGR 152

                        170       180
                 ....*....|....*....|....*....
gi 446458469 167 HQLANDlqteYYtripvmQTIFENNGFHV 195
Cdd:COG4976  153 YAHSLD----YV------RDLLAAAGFEV 171
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 9-166 4.01e-22

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 87.74  E-value: 4.01e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469   9 FDEWAHTYDsfvqgediqykevfaHYEDILEDVVNKSFGNVLEFGVGTGNLTNKLLLAGRTVYGIEPSREMRMIAKEKLP 88
Cdd:COG2226    1 FDRVAARYD---------------GREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAA 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469  89 KEF---SITEGDFLSFEVP-NSIDTIVSTYAFHHLTDDEKnvAVAKYSQLLNKGGKIVFADTIFADQDAYDKTVETAkqr 164
Cdd:COG2226   66 EAGlnvEFVVGDAEDLPFPdGSFDLVISSFVLHHLPDPER--ALAEIARVLKPGGRLVVVDFSPPDLAELEELLAEA--- 140


                 ..
gi 446458469 165 GF 166
Cdd:COG2226  141 GF 142
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 49-139 7.22e-18

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 75.29  E-value: 7.22e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469   49 VLEFGVGTGNLTNKLL-LAGRTVYGIEPSREMRMIAKEKLPKE---FSITEGDFLSFEVP-NSIDTIVSTYAFHHLTDDE 123
Cdd:pfam13649   1 VLDLGCGTGRLTLALArRGGARVTGVDLSPEMLERARERAAEAglnVEFVQGDAEDLPFPdGSFDLVVSSGVLHHLPDPD 80

                          90
                  ....*....|....*.
gi 446458469  124 KNVAVAKYSQLLNKGG 139
Cdd:pfam13649  81 LEAALREIARVLKPGG 96
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
47-145 1.65e-17

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 74.47  E-value: 1.65e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469  47 GNVLEFGVGTGNLTNKLL--LAGRTVYGIEPSREMRMIAKEKLPkEFSITEGDFLSFEVPNSIDTIVSTYAFHHLTDDEK 124
Cdd:COG4106    3 RRVLDLGCGTGRLTALLAerFPGARVTGVDLSPEMLARARARLP-NVRFVVADLRDLDPPEPFDLVVSNAALHWLPDHAA 81

                         90       100
                 ....*....|....*....|.
gi 446458469 125 nvAVAKYSQLLNKGGKIVFAD 145
Cdd:COG4106   82 --LLARLAAALAPGGVLAVQV 100
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 32-145 3.26e-17

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 74.28  E-value: 3.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469  32 AHYEDILEDVVNKSfGNVLEFGVGTGNLTNKLLLAGRTVYGIEPSREMRMIAKEKLPK-EFSITEGDFLSFEVP-NSIDT 109
Cdd:COG2227   12 RRLAALLARLLPAG-GRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAElNVDFVQGDLEDLPLEdGSFDL 90

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446458469 110 IVSTYAFHHLTDDEKnvAVAKYSQLLNKGGKIVFAD 145
Cdd:COG2227   91 VICSEVLEHLPDPAA--LLRELARLLKPGGLLLLST 124
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 50-143 1.31e-16

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 71.93  E-value: 1.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469   50 LEFGVGTGNLTNKLLLAGRTVYGIEPSREMRMIAKEKLPKE-FSITEGDF--LSFEvPNSIDTIVSTYAFHHLTDDEKnv 126
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREgLTFVVGDAedLPFP-DNSFDLVLSSEVLHHVEDPER-- 77

                          90
                  ....*....|....*..
gi 446458469  127 AVAKYSQLLNKGGKIVF 143
Cdd:pfam08241  78 ALREIARVLKPGGILII 94
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 47-172 1.83e-11

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 60.70  E-value: 1.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469  47 GNVLEFGVGTGNLTNKLL-LAGRTVYGIEPSREMRMIAKEKLPKEF--SIT--EGDFLSFE--VPNSIDTIVSTYAFHHL 119
Cdd:COG0500   28 GRVLDLGCGTGRNLLALAaRFGGRVIGIDLSPEAIALARARAAKAGlgNVEflVADLAELDplPAESFDLVVAFGVLHHL 107

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446458469 120 TDDEKNVAVAKYSQLLNKGGKIVFADTIFADQDAYDKTVETAKQRGFHQLAND 172
Cdd:COG0500  108 PPEEREALLRELARALKPGGVLLLSASDAAAALSLARLLLLATASLLELLLLL 160
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 50-141 8.25e-11

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 56.61  E-value: 8.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469   50 LEFGVGTGNLTNKLL--LAGRTVYGIEPSREMRMIAKEKLpKEFSITEGDFLSFEV-------PNSIDTIVSTYAFHHLt 120
Cdd:pfam08242   1 LEIGCGTGTLLRALLeaLPGLEYTGLDISPAALEAARERL-AALGLLNAVRVELFQldlgeldPGSFDVVVASNVLHHL- 78

                          90       100
                  ....*....|....*....|.
gi 446458469  121 dDEKNVAVAKYSQLLNKGGKI 141
Cdd:pfam08242  79 -ADPRAVLRNIRRLLKPGGVL 98
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 48-148 2.52e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.51  E-value: 2.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469  48 NVLEFGVGTGNLTNKLLLA-GRTVYGIEPSREMRMIAKE----KLPKEFSITEGDF--LSFEVPNSIDTIVSTYAFHHLT 120
Cdd:cd02440    1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELARKaaaaLLADNVEVLKGDAeeLPPEADESFDVIISDPPLHHLV 80

                         90       100
                 ....*....|....*....|....*...
gi 446458469 121 DDEKNVaVAKYSQLLNKGGKIVFADTIF 148
Cdd:cd02440   81 EDLARF-LEEARRLLKPGGVLVLTLVLA 107
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 43-145 6.40e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 55.90  E-value: 6.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469   43 NKSFGNVLEFGVGTGNLTNKLLLAGRTVYGIEPSREMRMIAKEKLPKE-FSITEGDFLSfevpNSIDTIVSTYAFHHLTD 121
Cdd:pfam13489  20 LPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALLNVRFDqFDEQEAAVPA----GKFDVIVAREVLEHVPD 95

                          90       100
                  ....*....|....*....|....
gi 446458469  122 DEKNVAVAKysQLLNKGGKIVFAD 145
Cdd:pfam13489  96 PPALLRQIA--ALLKPGGLLLLST 117
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 49-145 3.04e-09

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 53.78  E-value: 3.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469  49 VLEFGVGTGNLTnkLLLAGR---TVYGIEPSREM-----RMIAKEKLPKEFSITEGDFLSFEVPNSIDTIVSTYAFHHLT 120
Cdd:COG2230   55 VLDIGCGWGGLA--LYLARRygvRVTGVTLSPEQleyarERAAEAGLADRVEVRLADYRDLPADGQFDAIVSIGMFEHVG 132

                         90       100
                 ....*....|....*....|....*
gi 446458469 121 DDEKNVAVAKYSQLLNKGGKIVFAD 145
Cdd:COG2230  133 PENYPAYFAKVARLLKPGGRLLLHT 157
PRK08317 PRK08317
hypothetical protein; Provisional
 49-146 1.73e-08

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 53.02  E-value: 1.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469  49 VLEFGVGTGNLTnkLLLAGRT-----VYGIEPSREMRMIAKEK-----LPKEFSITEGDFLSFEvPNSIDTIVSTYAFHH 118
Cdd:PRK08317  23 VLDVGCGPGNDA--RELARRVgpegrVVGIDRSEAMLALAKERaaglgPNVEFVRGDADGLPFP-DGSFDAVRSDRVLQH 99

                         90       100
                 ....*....|....*....|....*...
gi 446458469 119 LTDDEKnvAVAKYSQLLNKGGKIVFADT 146
Cdd:PRK08317 100 LEDPAR--ALAEIARVLRPGGRVVVLDT 125
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 13-151 8.67e-08

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 50.75  E-value: 8.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469   13 AHTYDSFVqgeDIQyKEVFAHYEDILEDVVNKSFGNVLEFGVGTGNLTNKLLLAGRTVYGI--EPSREMRMIAKEKLPKE 90
Cdd:TIGR02072   6 AKTYDRHA---KIQ-REMAKRLLALLKEKGIFIPASVLDIGCGTGYLTRALLKRFPQAEFIalDISAGMLAQAKTKLSEN 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446458469   91 FSITEGDF--LSFEvPNSIDTIVSTYAFHHLTDdeKNVAVAKYSQLLNKGGkiVFADTIFADQ 151
Cdd:TIGR02072  82 VQFICGDAekLPLE-DSSFDLIVSNLALQWCDD--LSQALSELARVLKPGG--LLAFSTFGPG 139
rADc smart00650
Ribosomal RNA adenine dimethylases;
48-112 5.12e-07

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 47.89  E-value: 5.12e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446458469    48 NVLEFGVGTGNLTNKLLLAGRTVYGIEPSREMRMIAKEKLPKEFSIT--EGDFLSFEVP-NSIDTIVS 112
Cdd:smart00650  16 TVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFAAADNLTviHGDALKFDLPkLQPYKVVG 83
PTZ00338 PTZ00338
dimethyladenosine transferase-like protein; Provisional
 49-104 3.48e-06

dimethyladenosine transferase-like protein; Provisional


Pssm-ID: 240367 [Multi-domain]  Cd Length: 294  Bit Score: 46.53  E-value: 3.48e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446458469  49 VLEFGVGTGNLTNKLLLAGRTVYGIE--PsremRMIAKEK-------LPKEFSITEGDFLSFEVP 104
Cdd:PTZ00338  40 VLEIGPGTGNLTEKLLQLAKKVIAIEidP----RMVAELKkrfqnspLASKLEVIEGDALKTEFP 100
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
49-112 1.38e-05

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 44.51  E-value: 1.38e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446458469  49 VLEFGVGTGNLTNKLLLAGRTVYGIEPSREMRMIAKEKLPKE--FSITEGDFLSFEVPNsIDTIVS 112
Cdd:PRK14896  33 VLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDEIAAgnVEIIEGDALKVDLPE-FNKVVS 97
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 35-104 1.60e-05

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 44.35  E-value: 1.60e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446458469  35 EDILEDVVN----KSFGNVLEFGVGTGNLTNKLLLAGRTVYGIEPSREMRMIAKEKLP--KEFSITEGDFLSFEVP 104
Cdd:COG0030   23 PNIIRRIVDaagiTPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAayPNLTVIEGDALKVDLP 98
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 48-145 4.25e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 42.02  E-value: 4.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469   48 NVLEFGVGTGNLTNKL---LLAGRTVYGIEPSREM----RMIAKEKLPKEFSITEGDFLSFE---VPNSIDTIVSTYAFH 117
Cdd:pfam13847   6 RVLDLGCGTGHLSFELaeeLGPNAEVVGIDISEEAiekaRENAQKLGFDNVEFEQGDIEELPellEDDKFDVVISNCVLN 85

                          90       100
                  ....*....|....*....|....*...
gi 446458469  118 HLTDdeKNVAVAKYSQLLNKGGKIVFAD 145
Cdd:pfam13847  86 HIPD--PDKVLQEILRVLKPGGRLIISD 111
COG3963 COG3963
Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];
47-142 1.90e-04

Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];


Pssm-ID: 443163  Cd Length: 193  Bit Score: 40.58  E-value: 1.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469  47 GNVLEFGVGTGNLTNKLL---LAGRTVYGIEPSREMRMIAKEKLPkEFSITEGD------FLSFEVPNSIDTIVSTYAFH 117
Cdd:COG3963   47 GPVVELGPGTGVFTRAILargVPDARLLAVEINPEFAEHLRRRFP-RVTVVNGDaedlaeLLAEHGIGKVDAVVSGLPLL 125

                         90       100
                 ....*....|....*....|....*
gi 446458469 118 HLTDDEKNVAVAKYSQLLNKGGKIV 142
Cdd:COG3963  126 SFPPELRRAILDAAFRVLAPGGVFV 150
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 44-143 2.56e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 40.51  E-value: 2.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469  44 KSFGNVLEFGVGTGNLTnkLLLAGRT----VYGIEPSREMRMIAKE-----KLPKEFSITEGDFLSFE---VPNSIDTIV 111
Cdd:COG4123   36 KKGGRVLDLGTGTGVIA--LMLAQRSpgarITGVEIQPEAAELARRnvalnGLEDRITVIHGDLKEFAaelPPGSFDLVV 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 446458469 112 ST--YaFHHLT-----DDEKNVA-----------VAKYSQLLNKGGKIVF 143
Cdd:COG4123  114 SNppY-FKAGSgrkspDEARAIArhedaltledlIRAAARLLKPGGRFAL 162
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
34-173 6.51e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 36.55  E-value: 6.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446458469  34 YEDILEDVVNKSfGNVLEFGVGTGNLTnklLLAGR----TVYGIEPSREM-----RMIAKEKLPKEFSITEGDFLSFEVP 104
Cdd:COG4076   25 FKAAIERVVKPG-DVVLDIGTGSGLLS---MLAARagakKVYAVEVNPDIaavarRIIAANGLSDRITVINADATDLDLP 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446458469 105 NSIDTIVSTyAFHHLTDDEKNVAVAKYS--QLLNKGGKI------VFADTIFADQDAYDKTVETAKQRGFHQLANDL 173
Cdd:COG4076  101 EKADVIISE-MLDTALLDEGQVPILNHArkRLLKPGGRIiperitNAAQPVESPVDAEGFEDWQFDGFDFRLFGFLL 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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