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Conserved domains on  [gi|446466976|ref|WP_000544830|]
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MULTISPECIES: IS21-like element IS21 family helper ATPase IstB [Bacteria]

Protein Classification

ATP-binding protein( domain architecture ID 17609121)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain; similar to the ATPase subunit of IS21, IstB, that assembles into a clamshell-shaped decamer that sandwiches DNA to facilitate efficient transposition

CATH:  3.40.50.300
Gene Ontology:  GO:0005524

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 8-239 7.23e-119

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


:

Pssm-ID: 439516  Cd Length: 232  Bit Score: 339.06  E-value: 7.23e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976   8 LSRLKMEHLSYHVESLLEQAAKKELNYREFLCMALQQEWNGRHQRGMESRLKQARLPWVKTLEQFDFTFQPGIDRKVVRE 87
Cdd:NF038214   1 LRQLKLPGMARALEELAEQAAREELSFEEFLALLLEAELAERENRRIERRLKRARFPAAKTLEDFDFTAAPGLDKAQIRE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  88 LAGLAFVERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQLSYARVLILDEI 167
Cdd:NF038214  81 LATLDFIERAENVLLLGPPGTGKTHLAIALGYAACRQGYRVRFTTAADLVEQLAQARADGRLGRLLRRLARYDLLIIDEL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446466976 168 GYLPMNREEASLFFRLLNRRYEKASIILTSNKGFADWGEMFGDHVLATAILDRLLHHSTTLNIKGESYRLKE 239
Cdd:NF038214 161 GYLPFSREGANLLFELIADRYERGSTIITSNLPFSEWGEVFGDPTLAAAILDRLVHHAHILELKGESYRLKE 232
 
Name Accession Description Interval E-value
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 8-239 7.23e-119

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 339.06  E-value: 7.23e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976   8 LSRLKMEHLSYHVESLLEQAAKKELNYREFLCMALQQEWNGRHQRGMESRLKQARLPWVKTLEQFDFTFQPGIDRKVVRE 87
Cdd:NF038214   1 LRQLKLPGMARALEELAEQAAREELSFEEFLALLLEAELAERENRRIERRLKRARFPAAKTLEDFDFTAAPGLDKAQIRE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  88 LAGLAFVERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQLSYARVLILDEI 167
Cdd:NF038214  81 LATLDFIERAENVLLLGPPGTGKTHLAIALGYAACRQGYRVRFTTAADLVEQLAQARADGRLGRLLRRLARYDLLIIDEL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446466976 168 GYLPMNREEASLFFRLLNRRYEKASIILTSNKGFADWGEMFGDHVLATAILDRLLHHSTTLNIKGESYRLKE 239
Cdd:NF038214 161 GYLPFSREGANLLFELIADRYERGSTIITSNLPFSEWGEVFGDPTLAAAILDRLVHHAHILELKGESYRLKE 232
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
1-240 3.24e-116

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 332.90  E-value: 3.24e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976   1 MHELEVLLSRLKMEHLSYHVESLLEQAAKKELNYREFLCMALQQEWNGRHQRGMESRLKQARLPWVKTLEQFDFTFQPGI 80
Cdd:COG1484    3 MEELKELLKALKLPGMAEALDELLAQAACDELSYEEFLALLLEAEVAEREQRRIERRLKAARFPAAKTLEDFDFDAQPGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  81 DRKVVRELAGLAFVERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQLSYAR 160
Cdd:COG1484   83 DRRQILELATLDFIERGENLILLGPPGTGKTHLAIALGHEACRAGYRVRFTTAPDLVNELKEARADGRLERLLKRLAKVD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976 161 VLILDEIGYLPMNREEASLFFRLLNRRYEKASIILTSNKGFADWGEMFGDHVLATAILDRLLHHSTTLNIKGESYRLKEK 240
Cdd:COG1484  163 LLILDELGYLPLDAEGAELLFELISDRYERRSTIITSNLPFSEWGEVFGDPTLATAILDRLVHHAHIIELKGESYRLKEA 242
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 7-243 4.27e-96

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 281.64  E-value: 4.27e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976    7 LLSRLKMEHLSYHVESLLEQAAKKELNYREFLCMALQQEWNGRHQRGMESRLKQARLPWVKTLEQFDFTFQPGIDRKVVR 86
Cdd:pfam01695   2 QLKQLKLPGMAEAWEELSQQAASTSLSYEEFLEHLLEEELAWRDTRRLERLLRMAKLPPHKTLEDFDFTFAPGLDQRIVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976   87 ELAGLAFVERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQLSYARVLILDE 166
Cdd:pfam01695  82 ELASLSFIDRAQNVVLLGPPGVGKTHLAIALGVEACRAGYSVRFTSAADLVNQLKRAHGDGKLTRKLQQLLKPDVLILDE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446466976  167 IGYLPMNREEASLFFRLLNRRYEKASIILTSNKGFADWGEMFGDHVLATAILDRLLHHSTTLNIKGESYRLKEKRKA 243
Cdd:pfam01695 162 WGYLPLDQAEANLLFQVISKRYEHRSIILTSNLPFGEWGQVFGDAVLATAILDRLLHHCHIVPIKGESYRLKTKSEA 238
PRK09183 PRK09183
transposase/IS protein; Provisional
 2-249 3.78e-95

transposase/IS protein; Provisional


Pssm-ID: 181681  Cd Length: 259  Bit Score: 280.05  E-value: 3.78e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976   2 HE-LEVLLSRLKMEHLSYHVESLLEQAAKKELNYREFLCMALQQEWNGRHQRGMESRLKQARLPWVKTLEQFDFTFQPGI 80
Cdd:PRK09183   6 HQrLMALCGQLQLESLISAAPALAQQAVDQEWSYMDFLEHLLHEEKLARHQRKQAMYTRMAAFPAVKTFEEYDFTFATGA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  81 DRKVVRELAGLAFVERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQ-LSYA 159
Cdd:PRK09183  86 PQKQLQSLRSLSFIERNENIVLLGPSGVGKTHLAIALGYEAVRAGIKVRFTTAADLLLQLSTAQRQGRYKTTLQRgVMAP 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976 160 RVLILDEIGYLPMNREEASLFFRLLNRRYEKASIILTSNKGFADWGEMF-GDHVLATAILDRLLHHSTTLNIKGESYRLK 238
Cdd:PRK09183 166 RLLIIDEIGYLPFSQEEANLFFQVIAKRYEKGSMILTSNLPFGQWDQTFaGDAALTSAMLDRLLHHSHVVQIKGESYRLK 245

                        250
                 ....*....|.
gi 446466976 239 EKRKAGVLTKN 249
Cdd:PRK09183 246 QKRKAGVIAEA 256
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 79-224 5.96e-13

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 64.86  E-value: 5.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  79 GIDRKVVRELAGLAFVERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQEN----RLERQLQ 154
Cdd:cd00009    1 VGQEEAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANELFRPGAPFLYLNASDLLEGLVVAELFGhflvRLLFELA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446466976 155 QLSYARVLILDEIGYLPM----NREEASLFFRLLNRRYEKASIILTSNKGFadwgemfgDHVLATAILDRLLHH 224
Cdd:cd00009   81 EKAKPGVLFIDEIDSLSRgaqnALLRVLETLNDLRIDRENVRVIGATNRPL--------LGDLDRALYDRLDIR 146
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 96-224 2.85e-10

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 57.38  E-value: 2.85e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976    96 RSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAK---------------QENRLERQLQQLSYAR 160
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLlliivggkkasgsgeLRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976   161 VLILDEIGYLPMNREEASLFFRLLNR------RYEKASIILTSNkgfadWGEMFGDHVLAtAILDRLLHH 224
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRlllllkSEKNLTVILTTN-----DEKDLGPALLR-RRFDRRIVL 144
DnaA TIGR00362
chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; ...
 104-199 1.48e-05

chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273037 [Multi-domain]  Cd Length: 437  Bit Score: 45.60  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  104 GPPGVGKTHL--AIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQLSYARVLILDEIGYL---PMNREEas 178
Cdd:TIGR00362 144 GGVGLGKTHLlhAIGNEILENNPNAKVLYVSSEKFTNDFVNALRNNKMEEFKEKYRSVDLLLIDDIQFLagkERTQEE-- 221

                          90       100
                  ....*....|....*....|..
gi 446466976  179 lFFRLLNRRYEKAS-IILTSNK 199
Cdd:TIGR00362 222 -FFHTFNALHENNKqIVLTSDR 242
 
Name Accession Description Interval E-value
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 8-239 7.23e-119

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 339.06  E-value: 7.23e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976   8 LSRLKMEHLSYHVESLLEQAAKKELNYREFLCMALQQEWNGRHQRGMESRLKQARLPWVKTLEQFDFTFQPGIDRKVVRE 87
Cdd:NF038214   1 LRQLKLPGMARALEELAEQAAREELSFEEFLALLLEAELAERENRRIERRLKRARFPAAKTLEDFDFTAAPGLDKAQIRE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  88 LAGLAFVERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQLSYARVLILDEI 167
Cdd:NF038214  81 LATLDFIERAENVLLLGPPGTGKTHLAIALGYAACRQGYRVRFTTAADLVEQLAQARADGRLGRLLRRLARYDLLIIDEL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446466976 168 GYLPMNREEASLFFRLLNRRYEKASIILTSNKGFADWGEMFGDHVLATAILDRLLHHSTTLNIKGESYRLKE 239
Cdd:NF038214 161 GYLPFSREGANLLFELIADRYERGSTIITSNLPFSEWGEVFGDPTLAAAILDRLVHHAHILELKGESYRLKE 232
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
1-240 3.24e-116

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 332.90  E-value: 3.24e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976   1 MHELEVLLSRLKMEHLSYHVESLLEQAAKKELNYREFLCMALQQEWNGRHQRGMESRLKQARLPWVKTLEQFDFTFQPGI 80
Cdd:COG1484    3 MEELKELLKALKLPGMAEALDELLAQAACDELSYEEFLALLLEAEVAEREQRRIERRLKAARFPAAKTLEDFDFDAQPGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  81 DRKVVRELAGLAFVERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQLSYAR 160
Cdd:COG1484   83 DRRQILELATLDFIERGENLILLGPPGTGKTHLAIALGHEACRAGYRVRFTTAPDLVNELKEARADGRLERLLKRLAKVD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976 161 VLILDEIGYLPMNREEASLFFRLLNRRYEKASIILTSNKGFADWGEMFGDHVLATAILDRLLHHSTTLNIKGESYRLKEK 240
Cdd:COG1484  163 LLILDELGYLPLDAEGAELLFELISDRYERRSTIITSNLPFSEWGEVFGDPTLATAILDRLVHHAHIIELKGESYRLKEA 242
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 7-243 4.27e-96

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 281.64  E-value: 4.27e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976    7 LLSRLKMEHLSYHVESLLEQAAKKELNYREFLCMALQQEWNGRHQRGMESRLKQARLPWVKTLEQFDFTFQPGIDRKVVR 86
Cdd:pfam01695   2 QLKQLKLPGMAEAWEELSQQAASTSLSYEEFLEHLLEEELAWRDTRRLERLLRMAKLPPHKTLEDFDFTFAPGLDQRIVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976   87 ELAGLAFVERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQLSYARVLILDE 166
Cdd:pfam01695  82 ELASLSFIDRAQNVVLLGPPGVGKTHLAIALGVEACRAGYSVRFTSAADLVNQLKRAHGDGKLTRKLQQLLKPDVLILDE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446466976  167 IGYLPMNREEASLFFRLLNRRYEKASIILTSNKGFADWGEMFGDHVLATAILDRLLHHSTTLNIKGESYRLKEKRKA 243
Cdd:pfam01695 162 WGYLPLDQAEANLLFQVISKRYEHRSIILTSNLPFGEWGQVFGDAVLATAILDRLLHHCHIVPIKGESYRLKTKSEA 238
PRK09183 PRK09183
transposase/IS protein; Provisional
 2-249 3.78e-95

transposase/IS protein; Provisional


Pssm-ID: 181681  Cd Length: 259  Bit Score: 280.05  E-value: 3.78e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976   2 HE-LEVLLSRLKMEHLSYHVESLLEQAAKKELNYREFLCMALQQEWNGRHQRGMESRLKQARLPWVKTLEQFDFTFQPGI 80
Cdd:PRK09183   6 HQrLMALCGQLQLESLISAAPALAQQAVDQEWSYMDFLEHLLHEEKLARHQRKQAMYTRMAAFPAVKTFEEYDFTFATGA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  81 DRKVVRELAGLAFVERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQ-LSYA 159
Cdd:PRK09183  86 PQKQLQSLRSLSFIERNENIVLLGPSGVGKTHLAIALGYEAVRAGIKVRFTTAADLLLQLSTAQRQGRYKTTLQRgVMAP 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976 160 RVLILDEIGYLPMNREEASLFFRLLNRRYEKASIILTSNKGFADWGEMF-GDHVLATAILDRLLHHSTTLNIKGESYRLK 238
Cdd:PRK09183 166 RLLIIDEIGYLPFSQEEANLFFQVIAKRYEKGSMILTSNLPFGQWDQTFaGDAALTSAMLDRLLHHSHVVQIKGESYRLK 245

                        250
                 ....*....|.
gi 446466976 239 EKRKAGVLTKN 249
Cdd:PRK09183 246 QKRKAGVIAEA 256
PRK06526 PRK06526
transposase; Provisional
 3-251 3.77e-84

transposase; Provisional


Pssm-ID: 180607  Cd Length: 254  Bit Score: 252.10  E-value: 3.77e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976   3 ELEVLLSRLKMEHLSYHVESLLEQAAKKELNYREFLCMALQQEWNGRHQRGMESRLKQARLPWVKTLEQFDFTFQPGIDR 82
Cdd:PRK06526   4 ELAYLTRALKAPTLAGAVERLAERARAESWSHEEFLAACLQREVAARESHGGEGRIRAARFPARKSLEEFDFDHQRSLKR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  83 KVVRELAGLAFVERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQLSYARVL 162
Cdd:PRK06526  84 DTIAHLGTLDFVTGKENVVFLGPPGTGKTHLAIGLGIRACQAGHRVLFATAAQWVARLAAAHHAGRLQAELVKLGRYPLL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976 163 ILDEIGYLPMNREEASLFFRLLNRRYEKASIILTSNKGFADWGEMFGDHVLATAILDRLLHHSTTLNIKGESYRLKEKRK 242
Cdd:PRK06526 164 IVDEVGYIPFEPEAANLFFQLVSSRYERASLIVTSNKPFGRWGEVFGDDVVAAAMIDRLVHHAEVISLKGDSYRLKDRDL 243


                 ....*....
gi 446466976 243 AGVLTKNTT 251
Cdd:PRK06526 244 GRVPAATKT 252
PRK08181 PRK08181
transposase; Validated
 4-244 1.69e-49

transposase; Validated


Pssm-ID: 136670 [Multi-domain]  Cd Length: 269  Bit Score: 163.95  E-value: 1.69e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976   4 LEVLLSRLKMEHLSYHVESLLEQAAKKELNYREFLCMALQQEWNGRHQRGMESRLKQARLPWVKTLEQFDFTFQPGIDRK 83
Cdd:PRK08181  12 LGLLLNELRLPTIKTLWPQFAEQADKEGWPAARFLAAIAEHELAERARRRIERHLAEAHLPPGKTLDSFDFEAVPMVSKA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  84 VVREL-AGLAFVERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQLSYARVL 162
Cdd:PRK08181  92 QVMAIaAGDSWLAKGANLLLFGPPGGGKSHLAAAIGLALIENGWRVLFTRTTDLVQKLQVARRELQLESAIAKLDKFDLL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976 163 ILDEIGYLPMNREEASLFFRLLNRRYEKASIILTSNKGFADWGEMFGDHVLATAILDRLLHHSTTLNIKGESYR----LK 238
Cdd:PRK08181 172 ILDDLAYVTKDQAETSVLFELISARYERRSILITANQPFGEWNRVFPDPAMTLAAVDRLVHHATIFEMNVESYRrrtaLE 251


                 ....*.
gi 446466976 239 EKRKAG 244
Cdd:PRK08181 252 RKRGPG 257
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 79-224 5.96e-13

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 64.86  E-value: 5.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  79 GIDRKVVRELAGLAFVERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQEN----RLERQLQ 154
Cdd:cd00009    1 VGQEEAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANELFRPGAPFLYLNASDLLEGLVVAELFGhflvRLLFELA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446466976 155 QLSYARVLILDEIGYLPM----NREEASLFFRLLNRRYEKASIILTSNKGFadwgemfgDHVLATAILDRLLHH 224
Cdd:cd00009   81 EKAKPGVLFIDEIDSLSRgaqnALLRVLETLNDLRIDRENVRVIGATNRPL--------LGDLDRALYDRLDIR 146
PRK06835 PRK06835
DNA replication protein DnaC; Validated
 93-244 1.25e-11

DNA replication protein DnaC; Validated


Pssm-ID: 235871 [Multi-domain]  Cd Length: 329  Bit Score: 63.77  E-value: 1.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  93 FVERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQEN--RLERQLQQLSYARVLILDEIGYL 170
Cdd:PRK06835 179 FDKNNENLLFYGNTGTGKTFLSNCIAKELLDRGKSVIYRTADELIEILREIRFNNdkELEEVYDLLINCDLLIIDDLGTE 258

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446466976 171 PMNREEASLFFRLLNRRYEKA-SIILTSNKGFADWGEMFGDHvlataILDRLLHHSTTLNIKGESYRLKEKRKAG 244
Cdd:PRK06835 259 KITEFSKSELFNLINKRLLRQkKMIISTNLSLEELLKTYSER-----ISSRLLGNFTLLKFYGEDIRIKKNLQKK 328
PRK08116 PRK08116
hypothetical protein; Validated
 40-242 1.77e-11

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 62.73  E-value: 1.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  40 MALQQEW-NGRHQRGMEsRLK----QARLPWVKTLEQFDFTfqPGIDRKVvreLAGLAFVE-----RSENVILL--GPPG 107
Cdd:PRK08116  51 EAKEREEeNREKQRRIE-RLKsnslLDEKFRNSTFENFLFD--KGSEKAY---KIARKYVKkfeemKKENVGLLlwGSVG 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976 108 VGKTHLAIALGVKAVDAGHRVLFMP----LDRLIATLMKAKQENRLErQLQQLSYARVLILDEIGYLPMNREEASLFFRL 183
Cdd:PRK08116 125 TGKTYLAACIANELIEKGVPVIFVNfpqlLNRIKSTYKSSGKEDENE-IIRSLVNADLLILDDLGAERDTEWAREKVYNI 203

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976 184 LNRRYEKA-SIILTSNKGFADWGEMFGDHvlataILDRLLHHSTTLNIKGESYRlKEKRK 242
Cdd:PRK08116 204 IDSRYRKGlPTIVTTNLSLEELKNQYGKR-----IYDRILEMCTPVENEGKSYR-KEIAK 257
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 96-224 2.85e-10

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 57.38  E-value: 2.85e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976    96 RSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAK---------------QENRLERQLQQLSYAR 160
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLlliivggkkasgsgeLRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976   161 VLILDEIGYLPMNREEASLFFRLLNR------RYEKASIILTSNkgfadWGEMFGDHVLAtAILDRLLHH 224
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRlllllkSEKNLTVILTTN-----DEKDLGPALLR-RRFDRRIVL 144
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
89-199 7.29e-10

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 58.28  E-value: 7.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  89 AGLAFVE---RSENVILL-GPPGVGKTHL--AIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQLSYARVL 162
Cdd:COG0593   22 AALAVAEwpgKAYNPLFLyGGVGLGKTHLlhAIGNEALENNPGARVVYLTAEEFTNDFINAIRNNTIEEFKEKYRSVDVL 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 446466976 163 ILDEIGYL---PMNREEaslFFRLLNRRYE-KASIILTSNK 199
Cdd:COG0593  102 LIDDIQFLagkEATQEE---FFHTFNALREaGKQIVLTSDR 139
PRK07952 PRK07952
DNA replication protein DnaC; Validated
 101-243 2.50e-08

DNA replication protein DnaC; Validated


Pssm-ID: 181180 [Multi-domain]  Cd Length: 244  Bit Score: 53.23  E-value: 2.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976 101 ILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATlMKAKQENR---LERQLQQLSYARVLILDEIGYLPMNREEA 177
Cdd:PRK07952 103 IFSGKPGTGKNHLAAAICNELLLRGKSVLIITVADIMSA-MKDTFSNSetsEEQLLNDLSNVDLLVIDEIGVQTESRYEK 181

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446466976 178 SLFFRLLNRRY-EKASIILTSNKGFADWGEMFGDHVlataiLDRL-LHHSTTLNIKGESYRLKEKRKA 243
Cdd:PRK07952 182 VIINQIVDRRSsSKRPTGMLTNSNMEEMTKLLGERV-----MDRMrLGNSLWVIFNWDSYRSRVTGKE 244
PRK12377 PRK12377
putative replication protein; Provisional
 99-236 1.61e-06

putative replication protein; Provisional


Pssm-ID: 183482 [Multi-domain]  Cd Length: 248  Bit Score: 47.91  E-value: 1.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  99 NVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQ-LQQLSYARVLILDEIGYLPMNREEA 177
Cdd:PRK12377 103 NFVFSGKPGTGKNHLAAAIGNRLLAKGRSVIVVTVPDVMSRLHESYDNGQSGEKfLQELCKVDLLVLDEIGIQRETKNEQ 182

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446466976 178 SLFFRLLNRRYEKA-SIILTSNKGFADWGEMFGDHvlataILDRL-LHHSTTLNIKGESYR 236
Cdd:PRK12377 183 VVLNQIIDRRTASMrSVGMLTNLNHEAMSTLLGER-----VMDRMtMNGGRWVNFNWESWR 238
Bac_DnaA pfam00308
Bacterial dnaA protein;
104-199 2.36e-06

Bacterial dnaA protein;


Pssm-ID: 278724 [Multi-domain]  Cd Length: 219  Bit Score: 47.32  E-value: 2.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  104 GPPGVGKTHL--AIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQLSYARVLILDEIGYLPMNREEASLFF 181
Cdd:pfam00308  41 GGVGLGKTHLlhAIGNYALQNAPNLRVVYLTAEEFLNDFVDAIRDNKTNQFKEKYRNVDVLLIDDIQFLAGKEGTQEEFF 120

                          90
                  ....*....|....*....
gi 446466976  182 RLLNRRYEKA-SIILTSNK 199
Cdd:pfam00308 121 HTFNALHESGkQIVFSSDR 139
DnaA TIGR00362
chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; ...
 104-199 1.48e-05

chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273037 [Multi-domain]  Cd Length: 437  Bit Score: 45.60  E-value: 1.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  104 GPPGVGKTHL--AIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQLSYARVLILDEIGYL---PMNREEas 178
Cdd:TIGR00362 144 GGVGLGKTHLlhAIGNEILENNPNAKVLYVSSEKFTNDFVNALRNNKMEEFKEKYRSVDLLLIDDIQFLagkERTQEE-- 221

                          90       100
                  ....*....|....*....|..
gi 446466976  179 lFFRLLNRRYEKAS-IILTSNK 199
Cdd:TIGR00362 222 -FFHTFNALHENNKqIVLTSDR 242
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 99-198 4.17e-05

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 42.66  E-value: 4.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  99 NVILLGPPGVGKTHLAIALgvkavdAGHrvLFMPLDRLIATLMKAKQENRLERQLQQL-SYAR-----VLILDEI----- 167
Cdd:cd19481   28 GILLYGPPGTGKTLLAKAL------AGE--LGLPLIVVKLSSLLSKYVGESEKNLRKIfERARrlapcILFIDEIdaigr 99

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446466976 168 --GYLPMNREEASLFFRLLNR-----RYEKASIILTSN 198
Cdd:cd19481  100 krDSSGESGELRRVLNQLLTEldgvnSRSKVLVIAATN 137
PRK08939 PRK08939
primosomal protein DnaI; Reviewed
 54-238 4.29e-05

primosomal protein DnaI; Reviewed


Pssm-ID: 236353 [Multi-domain]  Cd Length: 306  Bit Score: 44.09  E-value: 4.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  54 MESRLKQArlpwvkTLEQFDFTfqpGIDRKVVRELAgLAFVERSEN------VILLGPPGVGKTHLAIALGVKAVDAGHR 127
Cdd:PRK08939 117 MPKDLLQA------SLADIDLD---DRDRLDALMAA-LDFLEAYPPgekvkgLYLYGDFGVGKSYLLAAIANELAKKGVS 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976 128 VLFMPLDRLIATLMKAKQENRLERQLQQLSYARVLILDEIGylpmnREEASLFFR-------LLNRRYEKASIILTSNKG 200
Cdd:PRK08939 187 STLLHFPEFIRELKNSISDGSVKEKIDAVKEAPVLMLDDIG-----AEQMSSWVRdevlgviLQYRMQEELPTFFTSNFD 261

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446466976 201 FADWGEMF-------GDHVLATAILDRLLHHSTTLNIKGESYRLK 238
Cdd:PRK08939 262 FDELEHHLaytqrgeDETWKAARIMERIRYLAKEVHLEGKNRRNN 306
dnaA PRK00149
chromosomal replication initiator protein DnaA;
102-199 1.26e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 234667 [Multi-domain]  Cd Length: 401  Bit Score: 42.81  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976 102 LLGPPGVGKTHL--AIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQLSYARVLILDEIGYLpmNREEASL 179
Cdd:PRK00149 104 IYGGVGLGKTHLlhAIGNYILEKNPNAKVVYVTSEKFTNDFVNALRNNTMEEFKEKYRSVDVLLIDDIQFL--AGKERTQ 181

                         90       100
                 ....*....|....*....|...
gi 446466976 180 --FFRLLNRRYEKAS-IILTSNK 199
Cdd:PRK00149 182 eeFFHTFNALHEAGKqIVLTSDR 204
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 94-187 1.50e-04

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 41.24  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  94 VERSENVILLGPPGVGKTHLAIALgvkavdAGHrvLFMPLDRLIATL----MKAKQENRLeRQL--QQLSYAR-VLILDE 166
Cdd:cd19518   31 VEPPRGVLLHGPPGCGKTMLANAI------AGE--LKVPFLKISATEivsgVSGESEEKI-RELfdQAISNAPcIVFIDE 101

                         90       100
                 ....*....|....*....|.
gi 446466976 167 IGYLPMNREEASlffRLLNRR 187
Cdd:cd19518  102 IDAITPKRESAQ---REMERR 119
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
72-199 2.08e-04

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 42.14  E-value: 2.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  72 FDFTFQPgiDRKVVRE---------LAGLAFVERSENVILLGPPGVGKTHLA---------------IALGVKAVDA-GH 126
Cdd:COG1474   19 LSPDYVP--DRLPHREeeieelasaLRPALRGERPSNVLIYGPTGTGKTAVAkyvleeleeeaeergVDVRVVYVNCrQA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976 127 RVLFMPLDRLIATLMKAKQ-----------ENRLERQLQQLSYARVLILDEIGYLPmnREEASLFFRLLNRRYE-----K 190
Cdd:COG1474   97 STRYRVLSRILEELGSGEDipstglstdelFDRLYEALDERDGVLVVVLDEIDYLV--DDEGDDLLYQLLRANEelegaR 174


                 ....*....
gi 446466976 191 ASIILTSNK 199
Cdd:COG1474  175 VGVIGISND 183
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
 94-213 2.45e-04

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 40.69  E-value: 2.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  94 VERSENVILLGPPGVGKTHLA-IALGVKAVDAGhRVLFMPLDrlIATLMKAKQENRL---------ERQLQQLSYA---- 159
Cdd:cd00267   22 LKAGEIVALVGPNGSGKSTLLrAIAGLLKPTSG-EILIDGKD--IAKLPLEELRRRIgyvpqlsggQRQRVALARAllln 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446466976 160 -RVLILDEIG-YL-PMNREEASLFFRLLNRryEKASIILTSNkgFADWGEMFGDHVL 213
Cdd:cd00267   99 pDLLLLDEPTsGLdPASRERLLELLRELAE--EGRTVIIVTH--DPELAELAADRVI 151
PhoH pfam02562
PhoH-like protein; PhoH is a cytoplasmic protein and predicted ATPase that is induced by ...
 100-134 2.78e-04

PhoH-like protein; PhoH is a cytoplasmic protein and predicted ATPase that is induced by phosphate starvation.


Pssm-ID: 460592 [Multi-domain]  Cd Length: 204  Bit Score: 40.93  E-value: 2.78e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 446466976  100 VILLGPPGVGKTHLAIALGVK---------------AVDAGHRVLFMPLD 134
Cdd:pfam02562  21 VFGIGPAGTGKTYLAVAMAVDalkngkvkriiltrpAVEAGEKLGFLPGD 70
radB PRK09361
DNA repair and recombination protein RadB; Provisional
 104-131 4.11e-04

DNA repair and recombination protein RadB; Provisional


Pssm-ID: 236482 [Multi-domain]  Cd Length: 225  Bit Score: 40.62  E-value: 4.11e-04
                         10        20
                 ....*....|....*....|....*...
gi 446466976 104 GPPGVGKTHLAIALGVKAVDAGHRVLFM 131
Cdd:PRK09361  30 GPPGSGKTNICLQLAVEAAKNGKKVIYI 57
COG1373 COG1373
Predicted ATPase, AAA+ superfamily [General function prediction only];
80-196 4.43e-04

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440984 [Multi-domain]  Cd Length: 405  Bit Score: 41.08  E-value: 4.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  80 IDRKVVRELagLAFVERSENVILLGPPGVGKTHLAIALGvkavDAGHRVLFMPLDR-LIATLMKAKQENRLERQLQQLSY 158
Cdd:COG1373    5 IKRKILDKL--LKLLDNRKAVVITGPRQVGKTTLLKQLA----KELENILYINLDDpRLRALAEEDPDDLLEALKELYPG 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446466976 159 ARVLILDEIGYLPmnreEASLFFRLLNRRYEKASIILT 196
Cdd:COG1373   79 KTYLFLDEIQRVP----EWEDALKRLVDDGRNGRFILT 112
AAA_14 pfam13173
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 100-201 5.83e-04

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 463799 [Multi-domain]  Cd Length: 128  Bit Score: 38.72  E-value: 5.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  100 VILLGPPGVGKTHLAIALGVKAVDAGHrVLFMPLDRLiatLMKAKQENRLERQLQQLSYAR--VLILDEIGYLPmnreEA 177
Cdd:pfam13173   5 LVITGPRQVGKTTLLLQLIKELLPPEN-ILYINLDDP---RLLKLADFELLELFLELLYPGktYLFLDEIQRVP----DW 76

                          90       100
                  ....*....|....*....|....*
gi 446466976  178 SLFFRLLNRRYEKASIILT-SNKGF 201
Cdd:pfam13173  77 ELALKRLYDDGPNGRVILTgSSALL 101
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
62-197 7.29e-04

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 40.94  E-value: 7.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  62 RLPWVKTLEQFDFTFQPGIDRKVVRELAGLAFVERSENVIL-LGPPGVGKT----HLAIALGVKAVDAGHRV-LFMPLDR 135
Cdd:COG5635  144 LLDADGLLVSLDDLYVPLNLLERIESLKRLELLEAKKKRLLiLGEPGSGKTtllrYLALELAERYLDAEDPIpILIELRD 223

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446466976 136 L-----IATLMKAKQENRLERQLQQLSYA----RVLIL----DEIGyLPMNREEASLFFRLLNRRYEKASIILTS 197
Cdd:COG5635  224 LaeeasLEDLLAEALEKRGGEPEDALERLlrngRLLLLldglDEVP-DEADRDEVLNQLRRFLERYPKARVIITS 297
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
99-167 1.28e-03

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 39.10  E-value: 1.28e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  99 NVILLGPPGVGKTHLAIALgvkAVDAGHRVLFMPLDRLIATLMkAKQENRLERQLQQLSYAR-VLILDEI 167
Cdd:COG1223   37 KILFYGPPGTGKTMLAEAL---AGELKLPLLTVRLDSLIGSYL-GETARNLRKLFDFARRAPcVIFFDEF 102
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
 100-221 1.32e-03

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 37.87  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976 100 VILLGPPGVGKTHLAIALGVKAVDAGHRVLF-MPLDRLIATLMKAKQENRLerqlqqlsyaRVLILDEIGYL------PM 172
Cdd:cd01120    1 ILITGPPGSGKTTLLLQFAEQALLSDEPVIFiSFLDTILEAIEDLIEEKKL----------DIIIIDSLSSLarasqgDR 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 446466976 173 NREEASLFFRLLNR-RYEKASIILTSNKGfaDWGEMFGDHVLATAILDRL 221
Cdd:cd01120   71 SSELLEDLAKLLRAaRNTGITVIATIHSD--KFDIDRGGSSNDERLLKSL 118
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 100-167 1.73e-03

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 37.57  E-value: 1.73e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446466976  100 VILLGPPGVGKTHLAIALgvkAVDAGHRVLFMPLDRLIATLMKAKqenrlERQLQQ-LSYAR-----VLILDEI 167
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAV---AKELGAPFIEISGSELVSKYVGES-----EKRLRElFEAAKklapcVIFIDEI 66
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 99-167 2.25e-03

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 38.91  E-value: 2.25e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446466976  99 NVILLGPPGVGKTHLA--IALGVK-------AVDAGhrvlfmpldrlIATLMKAKQENRLERQLQQlsyaR-VLILDEI 167
Cdd:PRK13342  38 SMILWGPPGTGKTTLAriIAGATDapfealsAVTSG-----------VKDLREVIEEARQRRSAGR----RtILFIDEI 101
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 100-178 2.62e-03

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 37.66  E-value: 2.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976 100 VILLGPPGVGKTHLAIALgvkAVDAGHRVLFmpldrLIATLMKAKQENRLERQLQQL-----SYARVLI-LDEIGYLPMN 173
Cdd:cd19503   37 VLLHGPPGTGKTLLARAV---ANEAGANFLS-----ISGPSIVSKYLGESEKNLREIfeearSHAPSIIfIDEIDALAPK 108


                 ....*
gi 446466976 174 REEAS 178
Cdd:cd19503  109 REEDQ 113
DEXXQc_SF1 cd18043
DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are ...
 94-130 3.02e-03

DEXXQ-box helicase domain of Superfamily 1 helicases; Superfamily 1 (SF1) helicases are nucleic acid motor proteins that couple ATP hydrolysis to translocation along with the concomitant unwinding of DNA or RNA. This is central to many aspects of cellular DNA and RNA metabolism and accordingly, they are implicated in a wide range of nucleic acid processing events including DNA replication, recombination, and repair as well as many aspects of RNA metabolism. Superfamily 1 helicases are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350801 [Multi-domain]  Cd Length: 127  Bit Score: 36.79  E-value: 3.02e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 446466976  94 VERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLF 130
Cdd:cd18043   11 ARNGKNVVIQGPPGTGKSQTIANIIANALARGKRVLF 47
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 91-117 3.10e-03

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 38.60  E-value: 3.10e-03
                         10        20
                 ....*....|....*....|....*..
gi 446466976  91 LAFVERSENVILLGPPGVGKTHLAIAL 117
Cdd:COG1401  215 LAALKTKKNVILAGPPGTGKTYLARRL 241
KaiC-like_C cd19487
C-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock ...
 94-140 3.51e-03

C-terminal domain of KaiC family protein; uncharacterized subfamily; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410895 [Multi-domain]  Cd Length: 219  Bit Score: 37.66  E-value: 3.51e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 446466976  94 VERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATL 140
Cdd:cd19487   16 LERGTSTLLIGPAGVGKSTLALQFAKAAAARGERSVLFSFDESIGTL 62
YlaK COG1875
Predicted ribonuclease YlaK, contains NYN-type RNase and PhoH-family ATPase domains [General ...
 100-176 3.54e-03

Predicted ribonuclease YlaK, contains NYN-type RNase and PhoH-family ATPase domains [General function prediction only];


Pssm-ID: 441479 [Multi-domain]  Cd Length: 441  Bit Score: 38.53  E-value: 3.54e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446466976 100 VILLGPPGVGKTHLAIALGVKAVdaghrvlfmpLDrliatlmkakqenrlERQLQQLSYARVLI-LDE-IGYLPMNREE 176
Cdd:COG1875  250 VTLLGKAGTGKTLLALAAGLEQV----------LE---------------EKRYRKIIVTRPTVpVGEdIGFLPGTEEE 303
recomb_radB TIGR02237
DNA repair and recombination protein RadB; This family consists exclusively of archaeal RadB ...
 94-166 3.68e-03

DNA repair and recombination protein RadB; This family consists exclusively of archaeal RadB protein, a homolog of bacterial RecA (TIGR02012), eukaryotic RAD51 (TIGR02239) and DMC1 (TIGR02238), and archaeal RadA (TIGR02236).


Pssm-ID: 274047 [Multi-domain]  Cd Length: 209  Bit Score: 37.78  E-value: 3.68e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446466976   94 VERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQLSYARVLILDE 166
Cdd:TIGR02237   9 VERGTITQIYGPPGSGKTNICMILAVNAARQGKKVVYIDTEGLSPERFKQIAEDRPERALSNFIVFEVFDFDE 81
AAA_22 pfam13401
AAA domain;
94-195 3.69e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 36.55  E-value: 3.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976   94 VERSENVILL-GPPGVGKTHLAIALGVKAVDAGHRVLFM---------PLDRLIATLMKAKQEN---------RLERQLQ 154
Cdd:pfam13401   1 IRFGAGILVLtGESGTGKTTLLRRLLEQLPEVRDSVVFVdlpsgtspkDLLRALLRALGLPLSGrlskeellaALQQLLL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 446466976  155 QLSYARVLILDEIGYLPMNREEasLFFRLLNRRYEKASIIL 195
Cdd:pfam13401  81 ALAVAVVLIIDEAQHLSLEALE--ELRDLLNLSSKLLQLIL 119
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 85-166 4.21e-03

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 38.29  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976   85 VRELAGLAFVERSENVILLGPPGVGKTHLAIALGvkAVDAGHRVLFMPLDR------LIATLM---KAKQENRLERQLqq 155
Cdd:TIGR03922 300 ARAERGLPVAQTSNHMLFAGPPGTGKTTIARVVA--KIYCGLGVLRKPLVRevsradLIGQYIgesEAKTNEIIDSAL-- 375

                          90
                  ....*....|.
gi 446466976  156 lsyARVLILDE 166
Cdd:TIGR03922 376 ---GGVLFLDE 383
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 100-195 5.99e-03

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 36.63  E-value: 5.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976 100 VILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQL----------QQLSYARVLILDEIGY 169
Cdd:COG4088    7 LILTGPPGSGKTTFAKALAQRLYAEGIAVALLHSDDFRRFLVNESFPKETYEEVvedvrtttadNALDNGYSVIVDGTFY 86

                         90       100
                 ....*....|....*....|....*.
gi 446466976 170 LPMNREEaslfFRLLNRRYEKASIIL 195
Cdd:COG4088   87 YRSWQRD----FRNLAKHKAPIHIIY 108
ArsA COG0003
Anion-transporting ATPase, ArsA/GET3 family [Inorganic ion transport and metabolism];
100-134 6.43e-03

Anion-transporting ATPase, ArsA/GET3 family [Inorganic ion transport and metabolism];


Pssm-ID: 439774  Cd Length: 299  Bit Score: 37.11  E-value: 6.43e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 446466976 100 VILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLD 134
Cdd:COG0003    6 IFFTGKGGVGKTTVAAATALALAERGKRTLLVSTD 40
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 99-167 6.57e-03

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 37.34  E-value: 6.57e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446466976  99 NVILLGPPGVGKTHLA--IALGVK-------AVDAGhrvlfmpldrlIATLMKAKQENRLERQLQQlsyaR-VLILDEI 167
Cdd:COG2256   51 SMILWGPPGTGKTTLArlIANATDaefvalsAVTSG-----------VKDIREVIEEARERRAYGR----RtILFVDEI 114
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 96-192 6.94e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 36.33  E-value: 6.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976   96 RSENVILLGPPGVGKTHLAIALGVKAVDAGHRVL------FMPLDRLIATLMKAKQENRLERQLQ--QLSYARVLILDEI 167
Cdd:pfam13191  23 RPPSVLLTGEAGTGKTTLLRELLRALERDGGYFLrgkcdeNLPYSPLLEALTREGLLRQLLDELEssLLEAWRAALLEAL 102

                          90       100
                  ....*....|....*....|....*.
gi 446466976  168 GYLP-MNREEASLFFRLLNRRYEKAS 192
Cdd:pfam13191 103 APVPeLPGDLAERLLDLLLRLLDLLA 128
PRK06921 PRK06921
hypothetical protein; Provisional
 95-237 7.82e-03

hypothetical protein; Provisional


Pssm-ID: 180750 [Multi-domain]  Cd Length: 266  Bit Score: 37.07  E-value: 7.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  95 ERSENVILLGPPGVGKTHLAIALGVKAVDAGH-RVLFMPldrLIATLMKAKQE-NRLERQLQQLSYARVLILDEIgYLPM 172
Cdd:PRK06921 115 SRKNSIALLGQPGSGKTHLLTAAANELMRKKGvPVLYFP---FVEGFGDLKDDfDLLEAKLNRMKKVEVLFIDDL-FKPV 190

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446466976 173 N-REEASLF-----FRLLNRRYEKASIILTSNKGFADwGEMFGDHVLATAILDRLLHHstTLNIKGESYRL 237
Cdd:PRK06921 191 NgKPRATEWqieqmYSVLNYRYLNHKPILISSELTID-ELLDIDEALGSRIVEMCKDY--LVIIKGDSFEL 258
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 99-223 9.02e-03

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 35.73  E-value: 9.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976   99 NVILLGPPGVGKT----HLAIAL--GVKAVDAGHRvlFMPLDRL-----IATLMKAKQENRLERQLQQlsyARVLILDEI 167
Cdd:pfam07728   1 GVLLVGPPGTGKTelaeRLAAALsnRPVFYVQLTR--DTTEEDLfgrrnIDPGGASWVDGPLVRAARE---GEIAVLDEI 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446466976  168 gylpmNREEASLF---FRLLNRRYekasiILTSNKGFADWGEMFGDHVLATA-ILDRLLH 223
Cdd:pfam07728  76 -----NRANPDVLnslLSLLDERR-----LLLPDGGELVKAAPDGFRLIATMnPLDRGLN 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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