|
Name |
Accession |
Description |
Interval |
E-value |
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
20-436 |
1.33e-141 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 410.87 E-value: 1.33e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 20 FLITYAIIISEKINRAVIALLGAALMVIVGVVDLHNAFTKHIEWG---TITLLIGMMILVNITSKSGVFQYVAIKAAKGA 96
Cdd:cd01116 1 FIITYALIIFEKVHRTVAALAGALWLVILGLATLSPDLETIVSWVdweTLALLLGMMIIVSILSETGVFEYLAIWAVKIS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 97 QGNPIKILISLSLLTALGSAFLDNVTTVLLVVPVTLSITRILQVNPVPYLLSEIIFSNIGGTATLIGDPPNIMIGSANkH 176
Cdd:cd01116 81 KGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGSAA-G 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 177 LDFNAFLLNLAPIVIIIIGVTATILYFMYRKQLIADPVQVKKLMSLDEKQYIKDPVLMKKSLTVLGLTIVGFMTHSIFHI 256
Cdd:cd01116 160 LTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLALAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPLGV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 257 DAAIIALTGATVLMLIGVKeHEIEEVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQKVIGITGGDISYASILILWVS 336
Cdd:cd01116 240 SLGWIALLGALLLLLLADK-LDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVILILWIS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 337 GIASATIDNIPFVATMIPLINDMAvglglSPSDAQIDVLWWALALGACLGGNGTLIGASANVIVAGIASREGHKFSYMEF 416
Cdd:cd01116 319 ALLSAFIDNIPVTATMIPIVKDLA-----SQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWEF 393
|
410 420
....*....|....*....|
gi 446467380 417 LKVGFPIMIVSLIISHIYIY 436
Cdd:cd01116 394 LKVGFPIMLVSLILATVYLL 413
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
12-440 |
5.57e-130 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 381.40 E-value: 5.57e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 12 QYYFAIAVFLITYAIIISEK--INRAVIALLGAALMVIVGVVDLHNAFtKHIEWGTITLLIGMMILVNITSKSGVFQYVA 89
Cdd:COG1055 1 MMILALAIFVLTYLLIILEPrgLNRAVAALLGAALLLLLGVVSLEDAL-EAIDWNTILFLLGMMIIVAILDESGFFEWLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 90 IKAAKGAQGNPIKILISLSLLTALGSAFLDNVTTVLLVVPVTLSITRILQVNPVPYLLSEIIFSNIGGTATLIGDPPNIM 169
Cdd:COG1055 80 IKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNPTNIM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 170 IGSANkHLDFNAFLLNLAPIVIIIIGVTATILYFMYRKQLiadpvQVKKLMSLDEKQYIKDPVLMKKSLTVLGLTIVGFM 249
Cdd:COG1055 160 IASAG-GLSFLDFLANLFPPSLVSLLVTLLVLYLLFRKEL-----PAAPDLEDDPKEAIKDRRLLRISLLVLALLLVGFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 250 THSIFHIDAAIIALTGATVLMLIGvkEHEIEEVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQKVIGITGGDISYAS 329
Cdd:COG1055 234 LHSFLGLPPALIALLGAAVLLLLA--RVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 330 ILILWVSGIASATIDNIPFVATMIPLINDMAVGLGLSPsdaqidvLWWALALGACLGGNGTLIGASANVIVAGIASREGH 409
Cdd:COG1055 312 LLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNPEP-------LWLALALGATLGGNLTPIGSAANVIVLGIAEKKGI 384
|
410 420 430
....*....|....*....|....*....|.
gi 446467380 410 KFSYMEFLKVGFPIMIVSLIISHIYIYLRYL 440
Cdd:COG1055 385 KISFGEFLKVGLPLTLLTLLIALLYLLLLYF 415
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
24-382 |
3.90e-60 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 199.46 E-value: 3.90e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 24 YAIIISEKINRAVIALLGAALMVIVGVVDLHNAFTkHIEWGTITLLIGMMILVNITSKSGVFQYVAIKAAKGAQGNPIKI 103
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALS-GIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 104 LISLSLLTALGSAFLDNVTTVLLVVPVTLSITRILQVNPVPYLLSEIIFSNIGGTATLIGDPPNIMIGSANKHLdFNAFL 183
Cdd:pfam03600 80 LVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLS-FGDFG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 184 LNLAPIVIIIIGVTATI-LYFMYRKQLIADPVQVKKLMSLdEKQYIKDPVLMKKSLTVLGLTIVGFMTHSIFHIDAAiia 262
Cdd:pfam03600 159 FFMFPPVGVALLLVGLLpLLLIFRKLLPVRKEEEAELEEL-RKRAIKDKLLLAISALVLALVILGFLLLSVLALAGA--- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 263 ltgatvLMLIGVKEHEIEEVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQKVIGITGGDIsyASILILWVSGIASAT 342
Cdd:pfam03600 235 ------LLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLSGLLV--ALALILWLSALLSAF 306
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 446467380 343 IDNIPFVATMIPLINDMAVGLGLSPsdaqIDVLWWALALG 382
Cdd:pfam03600 307 ISNVPTAALMAPIIVGMAPAAGLGD----PDPLAWALAVG 342
|
|
| PRK15445 |
PRK15445 |
arsenical efflux pump membrane protein ArsB; |
14-441 |
1.27e-24 |
|
arsenical efflux pump membrane protein ArsB;
Pssm-ID: 185342 Cd Length: 427 Bit Score: 105.25 E-value: 1.27e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 14 YFAIAVFLITYAIIISE--KINRAVIALLGAALMVIVGVVDLHNAFT-KHIEWGTITLLIGMMILVNITSKSGVFQYVAI 90
Cdd:PRK15445 1 LLAIAIFLLTLVLVIWQpkGLGIGWSALLGAVLALLTGVVSLGDVPVvWGIVWNATLTFIAIIIISLLLDEAGFFEWAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 91 KAAKGAQGNPIKILISLSLLTALGSAFLDNVTTVLLVVPVTLSITRILQVNPvPYLLSEIIFSN-IGGTATL---IGDPP 166
Cdd:PRK15445 81 HVARWAKGNGRKLFVYIVLLGAAVAALFANDGAALILTPIVLAMLLALGFSK-KATLAFVMAAGfIADTASLplvVSNLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 167 NIMigSANK-HLDFNAFLLNLAPIVIIIIGVTATILYFMYRKQLIA--DPVQVKklmslDEKQYIKDPVLMKKSLTVLGL 243
Cdd:PRK15445 160 NIV--SADYfGIGFAEYASVMVPVNLVSLAASLLVLWLYFRKDIPKtyDLELLK-----EPASAIKDPALFKLGWIVLAL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 244 TIVGFMTHSIFHIDAAIIALTGATVLMLIGVKEHEIE--EVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQKVIGIT 321
Cdd:PRK15445 233 LLVGYFVLEPLGIPVSAIAGVGALILLLVARRGHAINtkKVLKGAPWQIVIFSLGMYLVVYGLRNAGLTDYLAGVLNYLA 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 322 GGDISYASILILWVSGIASATIDNIPFVatmipLINDMAVGlGLSPSDAQIDVLWWALALGACLGGNGTLIGASANVIVA 401
Cdd:PRK15445 313 DQGLFAATLGTGFLAAFLSSVMNNMPTV-----LIGALAID-GSNATGVIKEAMIYANVIGSDLGPKITPIGSLATLLWL 386
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 446467380 402 GIASREGHKFSYMEFLKVGFPIMIVSLIISHIYIYLRYLM 441
Cdd:PRK15445 387 HVLAQKGVKISWGYYFKVGIIITLPVLLVTLLALALRLSL 426
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
16-437 |
1.05e-15 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 78.93 E-value: 1.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 16 AIAVFLITYAIIISEKINRAVIALLG-AALMVIVGVVDLHNAFTKHIEW--GTITLLIGMMILVNITSKSGVFQYVAIKA 92
Cdd:TIGR00785 13 LLAIFVAAIVGWILEPLPLPVTALLAiPIIAVLLGVLSAFKFKNALSGFadPTIWLFFGAFILATALVKTGLGKRIAYKL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 93 AKGAQGNPIKILISLSLL-TALGSAFLDNVTTVLLVVP-VTLSITRILQVNPVP-------YLLSEIIFS-NIGGTATLI 162
Cdd:TIGR00785 93 VGKMGGTTLGLGYFLVFLeTLLAPMWPSNTARAGGILLpIIKSLLPLLGSKPEKsprkigkYLMLGIAYSaSIGSSGFLT 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 163 GDPPNIMIGS-----ANKHLDFNAFLLNLAPIVIIIIGVTATILYFMYRKQLIA-DPVQVKKLMSLDEKQYIKdpVLMKK 236
Cdd:TIGR00785 173 GSAPNALAAGilskiLGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELKLkDEVDLWAKEELEEMGPMS--FREKA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 237 SLTVLGLTIVGFMTHSIFHIDAAIIALTGATVLMLIGVKEHEiEEVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQK 316
Cdd:TIGR00785 251 LLGIFLLALLLWIFGGSLGINASVVALLAVVLMLFLGIVTWK-DIQKNKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEK 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 317 VIGITGGDISYASILILWVSGIASAT--IDNIPFVATMIPLINDMAVGLGLSPSDAQIdvlwwALALGACLGGNGTLIGA 394
Cdd:TIGR00785 330 LVGILDGLSPTIAVLVLVVLFYIILYffASNTAHTAALVPIFFSVASAQGIPLELLAL-----ALALSASLMGFLTPYAT 404
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 446467380 395 SANVIVAGIASREghkfsYMEFLKVGFPIMIVSLIISHIYIYL 437
Cdd:TIGR00785 405 PPNAIAYGSGYVK-----IKDMWRVGAIIGIVGLIVLLLVGTL 442
|
|
| NhaD_1 |
NF038006 |
sodium:proton antiporter NhaD; Proteins of this family usually have 10-13 transmembrane ... |
150-419 |
7.04e-06 |
|
sodium:proton antiporter NhaD; Proteins of this family usually have 10-13 transmembrane regions. They extrudes Na+ or Li+ in exchange for H+. They have been identified and characterized in a number of bacterial species.
Pssm-ID: 439423 Cd Length: 405 Bit Score: 47.91 E-value: 7.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 150 IIFSNIGGTATLIGDPPNIMIGSAnKHLDFNAFLLNLAPIVIIIIgVTATILYFMYRKQliadpvqvkKLMSLDEKQYIK 229
Cdd:NF038006 129 VIAANAGGAFSPFGDITTLMVWQA-GLVRFQEFMELFGPALVNYL-VPAIVMSLFVPNR---------KPSAIEEHVELK 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 230 DPVlmKKSLTVLGLTIV-GFMTHSIFHIDAAIIALTGATVLMLIGV---------------------KEHEIE------- 280
Cdd:NF038006 198 RGA--RRIVLLFLLTIAtAVLCHAMLHLPPVLGMMMGLGYLQFFGYflrktlprslarkramasargDWRKLKrlgsvvp 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 281 -EVFASV---EWVTIFFFAGLFVLVGGLIDIGLIKMLAQkvIGITGGDISYASILIlwvsGIASATIDNIPFVATMIPLI 356
Cdd:NF038006 276 fDVFTRIsraEWDTLLFFYGVVMCVGGLGFLGYLGLVSE--TLYTGWNPVWANILL----GLLSSVVDNIPVMFAVLSMQ 349
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446467380 357 NDMAVGlglspsdaqidvLWWALALGACLGGNGTLIGASANVIVAGIASREGHKFSYMEFLKV 419
Cdd:NF038006 350 PEMSMG------------NWLLITLTAGVGGSLLSIGSAAGVALMGQARGIYTFFSHLKWAPV 400
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
20-436 |
1.33e-141 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 410.87 E-value: 1.33e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 20 FLITYAIIISEKINRAVIALLGAALMVIVGVVDLHNAFTKHIEWG---TITLLIGMMILVNITSKSGVFQYVAIKAAKGA 96
Cdd:cd01116 1 FIITYALIIFEKVHRTVAALAGALWLVILGLATLSPDLETIVSWVdweTLALLLGMMIIVSILSETGVFEYLAIWAVKIS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 97 QGNPIKILISLSLLTALGSAFLDNVTTVLLVVPVTLSITRILQVNPVPYLLSEIIFSNIGGTATLIGDPPNIMIGSANkH 176
Cdd:cd01116 81 KGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGSAA-G 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 177 LDFNAFLLNLAPIVIIIIGVTATILYFMYRKQLIADPVQVKKLMSLDEKQYIKDPVLMKKSLTVLGLTIVGFMTHSIFHI 256
Cdd:cd01116 160 LTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLALAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPLGV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 257 DAAIIALTGATVLMLIGVKeHEIEEVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQKVIGITGGDISYASILILWVS 336
Cdd:cd01116 240 SLGWIALLGALLLLLLADK-LDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVILILWIS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 337 GIASATIDNIPFVATMIPLINDMAvglglSPSDAQIDVLWWALALGACLGGNGTLIGASANVIVAGIASREGHKFSYMEF 416
Cdd:cd01116 319 ALLSAFIDNIPVTATMIPIVKDLA-----SQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWEF 393
|
410 420
....*....|....*....|
gi 446467380 417 LKVGFPIMIVSLIISHIYIY 436
Cdd:cd01116 394 LKVGFPIMLVSLILATVYLL 413
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
12-440 |
5.57e-130 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 381.40 E-value: 5.57e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 12 QYYFAIAVFLITYAIIISEK--INRAVIALLGAALMVIVGVVDLHNAFtKHIEWGTITLLIGMMILVNITSKSGVFQYVA 89
Cdd:COG1055 1 MMILALAIFVLTYLLIILEPrgLNRAVAALLGAALLLLLGVVSLEDAL-EAIDWNTILFLLGMMIIVAILDESGFFEWLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 90 IKAAKGAQGNPIKILISLSLLTALGSAFLDNVTTVLLVVPVTLSITRILQVNPVPYLLSEIIFSNIGGTATLIGDPPNIM 169
Cdd:COG1055 80 IKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNPTNIM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 170 IGSANkHLDFNAFLLNLAPIVIIIIGVTATILYFMYRKQLiadpvQVKKLMSLDEKQYIKDPVLMKKSLTVLGLTIVGFM 249
Cdd:COG1055 160 IASAG-GLSFLDFLANLFPPSLVSLLVTLLVLYLLFRKEL-----PAAPDLEDDPKEAIKDRRLLRISLLVLALLLVGFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 250 THSIFHIDAAIIALTGATVLMLIGvkEHEIEEVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQKVIGITGGDISYAS 329
Cdd:COG1055 234 LHSFLGLPPALIALLGAAVLLLLA--RVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 330 ILILWVSGIASATIDNIPFVATMIPLINDMAVGLGLSPsdaqidvLWWALALGACLGGNGTLIGASANVIVAGIASREGH 409
Cdd:COG1055 312 LLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNPEP-------LWLALALGATLGGNLTPIGSAANVIVLGIAEKKGI 384
|
410 420 430
....*....|....*....|....*....|.
gi 446467380 410 KFSYMEFLKVGFPIMIVSLIISHIYIYLRYL 440
Cdd:COG1055 385 KISFGEFLKVGLPLTLLTLLIALLYLLLLYF 415
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
24-435 |
7.81e-83 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 259.87 E-value: 7.81e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 24 YAIIISEKINRAVIALLGAALMVIVGVVDLHNAFTKhIEWGTITLLIGMMILVNITSKSGVFQYVAIKAAKGAQGNPIKI 103
Cdd:cd00625 1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSA-IDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 104 LISLSLLTALGSAFLDNVTTVLLVVPVTLSITRILQVNPVPYLLSEIIFSNIGGTATLIGDPPNIMIGSANkHLDFNAFL 183
Cdd:cd00625 80 LLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPPVPLLLALAFAANIGGAATPIGNPPNLIIASLS-GLGFLDFL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 184 LNLAPIVIIIIGVTATILYFMYRKQLIA-DPVQVKKLMSLDEKQYIKDPVLMKKSLTVLGLTIVGFmthsiFHIDAAIIA 262
Cdd:cd00625 159 AFMAPPALGLLLLLLGLLYLLFRKKLLLpDEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFF-----FLIPLGLIA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 263 LTGATVLMLIGVKEHEIEEVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQKVIGITGGDISYASILILWVSGIASAT 342
Cdd:cd00625 234 LLGALLLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNF 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 343 IDNIPFVATMIPLIndmavglglsPSDAQIDVLWWALALGACLGGNGTLIGASANVIVAGIASREGHKFSYMEFLKVGFP 422
Cdd:cd00625 314 ISNVPTVALLLPIA----------ASLAPPEPAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGISFGEFLKVGLP 383
|
410
....*....|...
gi 446467380 423 IMIVSLIISHIYI 435
Cdd:cd00625 384 LTLLSLVVSLLYL 396
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
24-382 |
3.90e-60 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 199.46 E-value: 3.90e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 24 YAIIISEKINRAVIALLGAALMVIVGVVDLHNAFTkHIEWGTITLLIGMMILVNITSKSGVFQYVAIKAAKGAQGNPIKI 103
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALS-GIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 104 LISLSLLTALGSAFLDNVTTVLLVVPVTLSITRILQVNPVPYLLSEIIFSNIGGTATLIGDPPNIMIGSANKHLdFNAFL 183
Cdd:pfam03600 80 LVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLS-FGDFG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 184 LNLAPIVIIIIGVTATI-LYFMYRKQLIADPVQVKKLMSLdEKQYIKDPVLMKKSLTVLGLTIVGFMTHSIFHIDAAiia 262
Cdd:pfam03600 159 FFMFPPVGVALLLVGLLpLLLIFRKLLPVRKEEEAELEEL-RKRAIKDKLLLAISALVLALVILGFLLLSVLALAGA--- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 263 ltgatvLMLIGVKEHEIEEVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQKVIGITGGDIsyASILILWVSGIASAT 342
Cdd:pfam03600 235 ------LLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLSGLLV--ALALILWLSALLSAF 306
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 446467380 343 IDNIPFVATMIPLINDMAVGLGLSPsdaqIDVLWWALALG 382
Cdd:pfam03600 307 ISNVPTAALMAPIIVGMAPAAGLGD----PDPLAWALAVG 342
|
|
| YbiR_permease |
cd01117 |
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ... |
31-435 |
4.55e-48 |
|
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.
Pssm-ID: 238537 [Multi-domain] Cd Length: 384 Bit Score: 169.00 E-value: 4.55e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 31 KINRAVIALLGAALMVIVGVVDLHNAFtKHIEWGTITLLIGMMILVNITSKSGVFQYVAIKAAKGAqGNPIKILISLSLL 110
Cdd:cd01117 10 RLDRWAIALLGAALMLLFGVISLEDAP-AAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKA-GSPRRLLFLLVLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 111 TALGSAFLDNVTTVLLVVPVTLSITRILQVNPVPYLLSEIIFSNIGGTATLIGDPPNIMIGSANKhLDFNAFLLNLAPIV 190
Cdd:cd01117 88 SGILSALLTNDTACLVFTPIVLELARVAGLPPIPLLLALATAANIGSAATPIGNPQNLLIASESG-ISFPFFLAAMAPLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 191 IIIIGVTATILYFMYRKQLIADPvqvkkLMSLDEKQYIKDPVLMKKSLTVLGLTIVGFMTHSIFHIdAAIIALTGATVLM 270
Cdd:cd01117 167 LLGLLLLLILLLVLFPGELKGLP-----LDKATKEEGVGARKLAVKLLVLILLLLVAFLALLGVIP-LWTAALVAAVLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 271 LIGVKeheIEEVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQKVIGITGGdisyasILILWVSGIASATIDNIPFVA 350
Cdd:cd01117 241 LTRLK---PRRVLKKVDWGLLLFFAGLFILVGGFAQGLPLEGLSRLLPLLDSV------LSLFLVSIGLSQLISNVPAVL 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 351 TMIPLIndmavglglsPSDAQIDvlWWALALGACLGGNGTLIGASANVIVAGIASREGHKFSYMEFLKVGFPIMIVSLII 430
Cdd:cd01117 312 LLLPFL----------PSADEKD--WLLLAAGSTIAGNLTLLGSAANLIVAEAAERRGVRLSFGEFLKYGVPLTLLTAAI 379
|
....*
gi 446467380 431 SHIYI 435
Cdd:cd01117 380 GILWL 384
|
|
| ArsB_permease |
cd01118 |
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ... |
16-431 |
1.19e-30 |
|
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.
Pssm-ID: 238538 [Multi-domain] Cd Length: 416 Bit Score: 122.37 E-value: 1.19e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 16 AIAVFLITYAIIISE--KINRAVIALLGAALMVIVGVVDLHNAFTK-HIEWGTITLLIGMMILVNITSKSGVFQYVAIKA 92
Cdd:cd01118 2 AIAIFVLTLVLVIWRpfGLPEAVWAVLGAVIALILGLVSPHDALEVwGIVWDVTLTLIGVILLSLLLDEEGFFEWVAALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 93 AKGAQGNPIKILISLSLLTALGSAFLDNVTTVLLVVPVTLSITRILQVNP---VPYLLSEIIFSNIGGTATLIGDPPNIm 169
Cdd:cd01118 82 ARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKnrtLPFLYACAFIADAASLPLPISNLVNI- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 170 IGSANKHLDFNAFLLNLAPIVIIIIGVTATILYFMYRKQLIADPV--QVKKlmsldEKQYIKDPVLMKKSLTVLGLTIVG 247
Cdd:cd01118 161 VTAGYFGIGFTEYAALMFLPSIVSILATYVVLYLFFRRALPKRLEtaSVKK-----PSLAIKDPLLFGLAWTLLVLLVVS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 248 FMTHSIFHIDAAIIALTGATVLMLIGVKEHEIE--EVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQKVIGITGGDI 325
Cdd:cd01118 236 AFGVDILLIPPSFIAGVLALIFLLLARRGGAINplKVLKEAPWGVLLFSLGLYVVVFGLKNAGLTAILADLLNWLVSQGL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 326 SYASILILWVSGIASATIDNIPFVatmipLINDMAVGLGLSPSdaqidVLWWALALGACLGGNGTLIGASANVIVAGIAS 405
Cdd:cd01118 316 LAAILGVGLLAAFLSNVMNNLPAV-----LIGALALAAGHAPE-----ALVYANLIGVDLGPKLTPIGSLATLLWLHVLR 385
|
410 420
....*....|....*....|....*.
gi 446467380 406 REGHKFSYMEFLKVGFPIMIVSLIIS 431
Cdd:cd01118 386 RKGIRVSWGYYLKVGLIVTPPVLVVT 411
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
70-437 |
1.96e-27 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 112.17 E-value: 1.96e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 70 IGMMILVNITSKSGVFQYVAIKAAKGAQGNPIKILISLSLLTALGSAFLDNVTTVLLVVPVTLSITRILQVN-----PVP 144
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEkrskfGSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 145 YLLSEIIFSNIGGTATLIGDPPNIMI-----GSANKHLDFNAFLLNLAPIVIIIIGVTATILYFMYRKQLIADP------ 213
Cdd:COG0471 81 LLLPIAFAASIGGMGTLIGTPPNLIAaglleEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEIKEVPgskevi 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 214 -VQVKKLMSLDEKQyikdpvlmKKSLTVLGLTIVGFMTHSIFHIDAAIIALTGATVLMLIGVKehEIEEVFASVEWVTIF 292
Cdd:COG0471 161 rEELAELGPLSRRE--------KIALAIFALTVLLWITGSLHGIPIAVVALLGAVLLLLTGVL--TWKDAYKSIPWGVLL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 293 FFAGLFVLVGGLIDIGLIKMLAQKVIGITGGDISYASILILW-VSGIASATIDNIPFVATMIPLINDMAVGLGLSPsdaq 371
Cdd:COG0471 231 LFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLAlLTLLLTEFASNTATAALLLPIAISLAQALGVNP---- 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446467380 372 idvlwWALALGACLGGNG---TLIGASANVIVAGIAsreghKFSYMEFLKVGFPIMIVSLIISHIYIYL 437
Cdd:COG0471 307 -----LPLALAVAFAASCaflLPVGTPPNAIVYGSG-----YYKFKDFLKVGLPLNLIGLVVLLLLGPL 365
|
|
| PRK15445 |
PRK15445 |
arsenical efflux pump membrane protein ArsB; |
14-441 |
1.27e-24 |
|
arsenical efflux pump membrane protein ArsB;
Pssm-ID: 185342 Cd Length: 427 Bit Score: 105.25 E-value: 1.27e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 14 YFAIAVFLITYAIIISE--KINRAVIALLGAALMVIVGVVDLHNAFT-KHIEWGTITLLIGMMILVNITSKSGVFQYVAI 90
Cdd:PRK15445 1 LLAIAIFLLTLVLVIWQpkGLGIGWSALLGAVLALLTGVVSLGDVPVvWGIVWNATLTFIAIIIISLLLDEAGFFEWAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 91 KAAKGAQGNPIKILISLSLLTALGSAFLDNVTTVLLVVPVTLSITRILQVNPvPYLLSEIIFSN-IGGTATL---IGDPP 166
Cdd:PRK15445 81 HVARWAKGNGRKLFVYIVLLGAAVAALFANDGAALILTPIVLAMLLALGFSK-KATLAFVMAAGfIADTASLplvVSNLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 167 NIMigSANK-HLDFNAFLLNLAPIVIIIIGVTATILYFMYRKQLIA--DPVQVKklmslDEKQYIKDPVLMKKSLTVLGL 243
Cdd:PRK15445 160 NIV--SADYfGIGFAEYASVMVPVNLVSLAASLLVLWLYFRKDIPKtyDLELLK-----EPASAIKDPALFKLGWIVLAL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 244 TIVGFMTHSIFHIDAAIIALTGATVLMLIGVKEHEIE--EVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQKVIGIT 321
Cdd:PRK15445 233 LLVGYFVLEPLGIPVSAIAGVGALILLLVARRGHAINtkKVLKGAPWQIVIFSLGMYLVVYGLRNAGLTDYLAGVLNYLA 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 322 GGDISYASILILWVSGIASATIDNIPFVatmipLINDMAVGlGLSPSDAQIDVLWWALALGACLGGNGTLIGASANVIVA 401
Cdd:PRK15445 313 DQGLFAATLGTGFLAAFLSSVMNNMPTV-----LIGALAID-GSNATGVIKEAMIYANVIGSDLGPKITPIGSLATLLWL 386
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 446467380 402 GIASREGHKFSYMEFLKVGFPIMIVSLIISHIYIYLRYLM 441
Cdd:PRK15445 387 HVLAQKGVKISWGYYFKVGIIITLPVLLVTLLALALRLSL 426
|
|
| PLN00136 |
PLN00136 |
silicon transporter; Provisional |
32-437 |
1.13e-20 |
|
silicon transporter; Provisional
Pssm-ID: 215070 [Multi-domain] Cd Length: 482 Bit Score: 94.29 E-value: 1.13e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 32 INRAVIALLGAALMVIVGVVDLHNAFTKhIEWGTITLLIGMMILVNITSKSGVFQYVAIKAAKGAQGNPiKILISLSLLT 111
Cdd:PLN00136 33 IGRTAGALLSAVLMIVFHVISPDDAYAS-IDLPILGLLFATMVVGSYLKNAGMFKHLGRLLAWRSQGGR-DLLCRVCVVT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 112 ALGSAFLDNVTTVLLVVPVTLSITRILQVNPVPYLLSEIIFSNIGGTATLIGDPPNIMIgSANKHLDFNAFLLNLAPIVI 191
Cdd:PLN00136 111 ALASALFTNDTCCVVLTEFVLELAAERNLPAKPFLLALASSANIGSSATPIGNPQNLVI-AFNSKITFPKFLLGILPAML 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 192 IIIGVTATILYFMYRKQL--IADPVQVKKLMS-------------------------------------LDEKQYIKDPV 232
Cdd:PLN00136 190 AGMAVNMVMLLCMYWKDLdgGAELSVDGKQMEaveegrspasakstkqqspallqaglngdgngdmssmMSENISTKHPW 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 233 LMK----------KSLTVlgLTIVGFMTHSIFHIDAAIIALTgaTVLMLIGVKEHEIEEVFASVEWVTIFFFAGLFVLVG 302
Cdd:PLN00136 270 FMQctehrrklflKSFAY--VVTVGMVVAYMVGLNMSWTAIT--TAIALVVVDFRDAEPCLDTVSYSLLVFFSGMFITVS 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 303 GLIDIGLIKML------AQKVIGITGgdISYASILILWVSGIASatidNIPFVAtmipLINDMAVGLGLSPSDAQIDVLW 376
Cdd:PLN00136 346 GFNKTGLPGAIwnfmapYSKVNSVGG--ISVLSVIILLLSNLAS----NVPTVL----LMGDEVAAAAALISPAAVTRSW 415
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446467380 377 WALALGACLGGNGTLIGASANVIV---AGIASREGHKFSYMEFLKVGFPimiVSLIISHIYIYL 437
Cdd:PLN00136 416 LLLAWVSTVAGNLSLLGSAANLIVceqARRAPRNAYDLTFWQHIVFGVP---STLIVTAIGIPL 476
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
17-437 |
1.99e-18 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 86.48 E-value: 1.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 17 IAVFLITYAIIISEKINRAVIALLGAALMVIVGVVDLHNAFTKHIEwGTITLLIGMMILVNITSKSGVFQYVAIKAAKGA 96
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSD-PAVILFLAGFILGAALTRTGLAKRIATKLLKRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 97 QGNPIKILISLSLLTALGSAFLDNVTTVLLVVPVTLSITRILQVNPVPYLLSEIIFSNIGGTATLIGDPPNIMIGSANKH 176
Cdd:cd01115 80 GKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLES 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 177 LDFNAF-LLNLAPIVIIIIGVTATILYFMYRkqliadpvqvkklmsldekqyikdpvlmkksLTVLGLTIVGF-MTHSIF 254
Cdd:cd01115 160 LGGQGFsFFEFTPIGLPLLIIGLLYLWFIFR-------------------------------LAVLIITIVLLaALAAIT 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 255 HIDAAIIALTGATVLMLIGVKEHEiEEVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQKVIGITGGDISYASILILW 334
Cdd:cd01115 209 GLLPVSVAIAIGAIVLVFGGVLLT-KEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISLLGGLPPFAILLLLC 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 335 VSGIASAT-IDNIPFVATMIPLINDMAVGLGLSPSdaqidvlwwALALGACLGGN---GTLIGASANVIVAGiasreGHK 410
Cdd:cd01115 288 LLTLVLTNfISNTATAVLLAPIALSIALSLGLPPE---------ALLLAVAIGAScafMLPVGTPPNAIVLG-----PGG 353
|
410 420
....*....|....*....|....*..
gi 446467380 411 FSYMEFLKVGFPIMIVSLIISHIYIYL 437
Cdd:cd01115 354 YKFSDFAKVGLPLSILSLVVSVTMIPL 380
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
256-441 |
3.23e-16 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 79.28 E-value: 3.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 256 IDAAIIALTGATVLMLIGVkeHEIEEVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQKVIGITGGDISYASILILWV 335
Cdd:pfam03600 9 LPRDVVALLGAVLLVLLGV--LTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 336 SGIASATIDNIPFVATMIPLINDMAVGLGLSPSDAQIdvlwwALALGACLGGNGTLIGASANVIVAGIASREGHKFSYME 415
Cdd:pfam03600 87 TALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLI-----ALAFAANIGGTATPIGDPPNIIIASALGLSFGDFGFFM 161
|
170 180
....*....|....*....|....*.
gi 446467380 416 FLKVGFPIMIVSLIIshIYIYLRYLM 441
Cdd:pfam03600 162 FPPVGVALLLVGLLP--LLLIFRKLL 185
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
16-437 |
1.05e-15 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 78.93 E-value: 1.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 16 AIAVFLITYAIIISEKINRAVIALLG-AALMVIVGVVDLHNAFTKHIEW--GTITLLIGMMILVNITSKSGVFQYVAIKA 92
Cdd:TIGR00785 13 LLAIFVAAIVGWILEPLPLPVTALLAiPIIAVLLGVLSAFKFKNALSGFadPTIWLFFGAFILATALVKTGLGKRIAYKL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 93 AKGAQGNPIKILISLSLL-TALGSAFLDNVTTVLLVVP-VTLSITRILQVNPVP-------YLLSEIIFS-NIGGTATLI 162
Cdd:TIGR00785 93 VGKMGGTTLGLGYFLVFLeTLLAPMWPSNTARAGGILLpIIKSLLPLLGSKPEKsprkigkYLMLGIAYSaSIGSSGFLT 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 163 GDPPNIMIGS-----ANKHLDFNAFLLNLAPIVIIIIGVTATILYFMYRKQLIA-DPVQVKKLMSLDEKQYIKdpVLMKK 236
Cdd:TIGR00785 173 GSAPNALAAGilskiLGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELKLkDEVDLWAKEELEEMGPMS--FREKA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 237 SLTVLGLTIVGFMTHSIFHIDAAIIALTGATVLMLIGVKEHEiEEVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQK 316
Cdd:TIGR00785 251 LLGIFLLALLLWIFGGSLGINASVVALLAVVLMLFLGIVTWK-DIQKNKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEK 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 317 VIGITGGDISYASILILWVSGIASAT--IDNIPFVATMIPLINDMAVGLGLSPSDAQIdvlwwALALGACLGGNGTLIGA 394
Cdd:TIGR00785 330 LVGILDGLSPTIAVLVLVVLFYIILYffASNTAHTAALVPIFFSVASAQGIPLELLAL-----ALALSASLMGFLTPYAT 404
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 446467380 395 SANVIVAGIASREghkfsYMEFLKVGFPIMIVSLIISHIYIYL 437
Cdd:TIGR00785 405 PPNAIAYGSGYVK-----IKDMWRVGAIIGIVGLIVLLLVGTL 442
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
295-439 |
4.06e-15 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 76.35 E-value: 4.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 295 AGLFVLVGGLIDIGLIKMLAQKVIGITGGDISYASILILWVSGIASATIDNIPFVATMIPLINDMAVGLGLSPSDAQIDV 374
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEKRSKFGSA 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446467380 375 LWWALALGACLGGNGTLIGASANVIVAGIASRE-GHKFSYMEFLKVGFPIMIVSLIISHIYIYLRY 439
Cdd:COG0471 81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEAtGIPISFFEWMLVGLPVALVGLLLLWLVLYRLL 146
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
256-439 |
3.38e-12 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 67.66 E-value: 3.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 256 IDAAIIALTGATVLMLIGVKEheIEEVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQKVIGITGGDISYASILILwV 335
Cdd:cd00625 9 LPRAVVALLGAVLLVLLGVVS--PKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLLLLML-L 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 336 SGIASATIDNIPFVATMIPLINDMAVGLGLSPSDAqidvLWWALALGACLGGNGTLIGASANVIVAGIAsreghKFSYME 415
Cdd:cd00625 86 TAALSAFFSNDATAVLLTPIVLALLRKLGLSPPVP----LLLALAFAANIGGAATPIGNPPNLIIASLS-----GLGFLD 156
|
170 180
....*....|....*....|....
gi 446467380 416 FLKVGFPIMIVSLIISHIYIYLRY 439
Cdd:cd00625 157 FLAFMAPPALGLLLLLLGLLYLLF 180
|
|
| ArsB |
pfam02040 |
Arsenical pump membrane protein; |
15-437 |
4.21e-11 |
|
Arsenical pump membrane protein;
Pssm-ID: 460426 Cd Length: 423 Bit Score: 64.61 E-value: 4.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 15 FAIAVFLITYAIIISEKINRAV--IALLGAALMVIVGVVDLHNAFTKHIEWGTITLLIGMMILVNIT-SKSGVFQYVAIK 91
Cdd:pfam02040 6 FALFIFLLILQLKILQIGNLACggAACAGAAGALIAGDVLFHDGITVNAILAFAAIAFIAIILDNIGfDEIAAFEMAAAA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 92 AAKGAQGNPIKILISLSLLTALGSAFLDNVTTVLLVVPVTLSITRILQVNPvpyllsEIIFSNI--GGTATLIGDPPNIM 169
Cdd:pfam02040 86 KAKAAKGFGVRMFLGAILAAAFAAAGAALDGAAIILAMIRAAHFNAKHFFE------FIIAPFFiaDGFIADFTSLNFVN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 170 IGSANK-HLDF--NAFLLNLAPIVIIIIGVTATILYFMYRKQLIADPVQVKKLMSLDEKQYIKDPVLMKKSLTVLGLTIV 246
Cdd:pfam02040 160 INLADIfHADFfdIAFIDVAPRLFSLLAFIILASIFFLKLFFKKSDLKEVDKPEEAIKDEAIFDLNMFILGLLIIGLFAI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 247 GFMTHSIFHIDAAIIALTGATVLMLIGVKEHEI--EEVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQKVIGITGGD 324
Cdd:pfam02040 240 EFFAIEFFSIAGSIAAGFIAAAFKIAAQHSKAVhkEAPVAEAFFAIGFFSIGMGVRNAGLRDAGLDDILAAADQAAAAGG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 325 ISYASILILWVSGIASATIDNIPFVATMiplindmavglGLSPSDAQIDVLWWALALGACLGGNGTLIGASANVIVAGIA 404
Cdd:pfam02040 320 IFAGFIAAGFIAAILNLIMNMIDALAIA-----------ALAIAGMDREALIRAALIGADLGGKDLGIGILAIGLLAHLL 388
|
410 420 430
....*....|....*....|....*....|...
gi 446467380 405 SREGHKFSYMEFLKVGFPIMIVSLIISHIYIYL 437
Cdd:pfam02040 389 SHHGLKHKGGKIFKGGIFKTGIILLIPLLGITI 421
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
256-439 |
3.81e-10 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 61.50 E-value: 3.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 256 IDAAIIALTGATVLMLIGV--KEHEIEEVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQKVIGITGGDISYASILIL 333
Cdd:cd01116 13 VHRTVAALAGALWLVILGLatLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 334 WVSGIASATIDNIPFVATMIPLINDMAVGLGLSPSDAQIdvlwwALALGACLGGNGTLIGASANVIVAGIAsreghKFSY 413
Cdd:cd01116 93 LLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLI-----SEVIAANIGGAATLIGDPPNIMIGSAA-----GLTF 162
|
170 180
....*....|....*....|....*.
gi 446467380 414 MEFLKVGFPIMIVSLIISHIYIYLRY 439
Cdd:cd01116 163 NDFLLHMLPSVVLALVVTFILLYFLY 188
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
290-439 |
7.08e-10 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 60.82 E-value: 7.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 290 TIFFFAGLFVLVGGLIDIGLIKMLAQKVIGITGGDISYASILILWVS-GIASATIDNIPFV-ATMIPLINDMAVGLGLSP 367
Cdd:TIGR00785 65 TIWLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLGYFLVFLEtLLAPMWPSNTARAgGILLPIIKSLLPLLGSKP 144
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446467380 368 SDAQIDV---LWWALALGACLGGNGTLIGASANVIVAGIASREGHK-FSYMEFLKVGFPIMIVSLIISHIYIYLRY 439
Cdd:TIGR00785 145 EKSPRKIgkyLMLGIAYSASIGSSGFLTGSAPNALAAGILSKILGIqISWGDWFLAGLPLGIILLLLVPLLLYVLF 220
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
15-206 |
6.73e-09 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 57.47 E-value: 6.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 15 FAIAVFLITYAIIISE---KINRAVIALLGAALMVIVGVVDLHNAFtKHIEWGTITLLIGMMILVNITSKSGVFQYVAIK 91
Cdd:COG0471 176 IALAIFALTVLLWITGslhGIPIAVVALLGAVLLLLTGVLTWKDAY-KSIPWGVLLLFGGGLALGAALEKTGLAAWLADA 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 92 AAKGAQG-NPIKILISLSLLTALGSAFLDNVTTVLLVVPVTLSITRILQVNPVPYLLSeIIFSNIGGTATLIGDPPNIMI 170
Cdd:COG0471 255 LLPLLGGlSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALA-VAFAASCAFLLPVGTPPNAIV 333
|
170 180 190
....*....|....*....|....*....|....*.
gi 446467380 171 GSAnKHLDFNAFLLNLAPIVIIIIGVTATILYFMYR 206
Cdd:COG0471 334 YGS-GYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWP 368
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
14-201 |
3.71e-08 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 54.95 E-value: 3.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 14 YFAIAVFLITYAIIISEKINRAVIALLGAALMVIVGVVDLHNAFtKHIEWGTITLLIGMMILVNITSKSGVFQYVAIKAA 93
Cdd:cd00625 211 LALLLLLLFVLLFFFLIPLGLIALLGALLLLLLLVRGLDPEEVL-KSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLV 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 94 KGAQGNPIKILISLSLLTALGSAFLDNVTTVLLVVPVTLSItrilqVNPVPYLLSEIIFSNIGGTATLIGDPPNI----M 169
Cdd:cd00625 290 ALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASL-----APPEPAWLALALGSTLGGNLTLIGSLANLiplgA 364
|
170 180 190
....*....|....*....|....*....|..
gi 446467380 170 IGSANKHLDFNAFLLNLAPIVIIIIGVTATIL 201
Cdd:cd00625 365 AENAGVGISFGEFLKVGLPLTLLSLVVSLLYL 396
|
|
| YbiR_permease |
cd01117 |
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ... |
253-440 |
6.21e-08 |
|
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.
Pssm-ID: 238537 [Multi-domain] Cd Length: 384 Bit Score: 54.21 E-value: 6.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 253 IFHIDAAIIALTGATVLMLIGVKEheIEEVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLAQKVIGITGGDISYASILI 332
Cdd:cd01117 8 GLRLDRWAIALLGAALMLLFGVIS--LEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAGSPRRLLFLLV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 333 LwVSGIASATIDNIPFVATMIPLINDMAVGLGLSPSDAQIdvlwwALALGACLGGNGTLIGASANVIvagIASREGhkFS 412
Cdd:cd01117 86 L-LSGILSALLTNDTACLVFTPIVLELARVAGLPPIPLLL-----ALATAANIGSAATPIGNPQNLL---IASESG--IS 154
|
170 180
....*....|....*....|....*...
gi 446467380 413 YMEFLKVGFPIMIVSLIISHIYIYLRYL 440
Cdd:cd01117 155 FPFFLAAMAPLALLGLLLLLILLLVLFP 182
|
|
| PLN00137 |
PLN00137 |
NHAD transporter family protein; Provisional |
16-406 |
1.01e-07 |
|
NHAD transporter family protein; Provisional
Pssm-ID: 215071 Cd Length: 424 Bit Score: 53.93 E-value: 1.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 16 AIAVFLITYAIIISEK---INRAVIALLGA-ALMVIVG---------VVDLHNAFTKHIEwgTITLLIGMMILVNITSKS 82
Cdd:PLN00137 8 MALVFGAGYAGIIFEEslaFNKSGVALLMAvSLWVIRAigapsleivTLELRHALAEVSE--IVFFLLGAMTIVEIVDAH 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 83 GVFQYVAikaAKGAQGNPIKILISLSLLTALGSAFLDNVTTVLLVVPVTLSIT------RILQVNPVpyllseiIFSNIG 156
Cdd:PLN00137 86 QGFKLVT---DSITTRSPRTLLWVVGFITFFLSSILDNLTTTIVMVSLLRKLVppseyrKLLGAVVV-------VAANAG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 157 GTATLIGDPPNIMIGSANKHLDFNAFLLNLAPIVIIIigvtATILYFMYRKQLIADPVQVKKLMSLDEKqyikdpvLMKK 236
Cdd:PLN00137 156 GAWTPIGDVTTTMLWIHGQISTLPTMQGLFLPSAVSL----AVPLALMSLTSEENGSPQDSSPLLASEQ-------MAPR 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 237 SLTVLGLTIVGFMTHSIFHIDAA----IIALTGATVLMLI------GVKEHEIEEVFAS---VEWVTIFFFAGLFVLVGG 303
Cdd:PLN00137 225 GQLVFGVGVGALLFVPVFKALTGlppyMGMLLGLGVLWILtdaihyGESERQALKVPQAlsrIDTQGILFFLGILLSVGS 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 304 LIDIGLIKMLAQKVIG-ITGGDISYASIlilwvsGIASATIDNIPFV-ATMiplindmavGLGLSPSDAQIDVLWWALAL 381
Cdd:PLN00137 305 LDAAGILRELANYLDAnIPNVELIASAI------GVASAIIDNVPLVaATM---------GMYDLTDYPMDSELWQLIAL 369
|
410 420
....*....|....*....|....*
gi 446467380 382 GACLGGNGTLIGASANVIVAGIASR 406
Cdd:PLN00137 370 CAGTGGSLLVIGSAAGVAFMGMEKV 394
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
235-430 |
1.76e-06 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 50.06 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 235 KKSLTVLGLTIVGFMTHSIFHIDAAIIALTGATVLMLIGVKEHEiEEVFASVEWVTIFFFAGLFVLVGGLIDIGLIKMLA 314
Cdd:pfam00939 270 KALLGLFVLLLLLWIFGGSLNIDATTVAIIGLALMLLLRILDWK-DIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLG 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 315 QKVIGITGGDISYASILILWVSGIASATI--DNIPFVATMIPLINDMAVGLGLSPsdaqIDVLWWALALGACLGGNGTLI 392
Cdd:pfam00939 349 NTLSTSLSGFSPAMAFIIILSLFYLSHYLfaSATAHTAAMLPIFAAVAQAIPGAP----PLLAALLLGFAISLGGFLTPY 424
|
170 180 190
....*....|....*....|....*....|....*...
gi 446467380 393 GASANVIVAGIasregHKFSYMEFLKVGFPIMIVSLII 430
Cdd:pfam00939 425 GTGPGPIYFGS-----GYLKVKDWWRIGAILTIIGLLI 457
|
|
| NhaD_1 |
NF038006 |
sodium:proton antiporter NhaD; Proteins of this family usually have 10-13 transmembrane ... |
150-419 |
7.04e-06 |
|
sodium:proton antiporter NhaD; Proteins of this family usually have 10-13 transmembrane regions. They extrudes Na+ or Li+ in exchange for H+. They have been identified and characterized in a number of bacterial species.
Pssm-ID: 439423 Cd Length: 405 Bit Score: 47.91 E-value: 7.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 150 IIFSNIGGTATLIGDPPNIMIGSAnKHLDFNAFLLNLAPIVIIIIgVTATILYFMYRKQliadpvqvkKLMSLDEKQYIK 229
Cdd:NF038006 129 VIAANAGGAFSPFGDITTLMVWQA-GLVRFQEFMELFGPALVNYL-VPAIVMSLFVPNR---------KPSAIEEHVELK 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 230 DPVlmKKSLTVLGLTIV-GFMTHSIFHIDAAIIALTGATVLMLIGV---------------------KEHEIE------- 280
Cdd:NF038006 198 RGA--RRIVLLFLLTIAtAVLCHAMLHLPPVLGMMMGLGYLQFFGYflrktlprslarkramasargDWRKLKrlgsvvp 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 281 -EVFASV---EWVTIFFFAGLFVLVGGLIDIGLIKMLAQkvIGITGGDISYASILIlwvsGIASATIDNIPFVATMIPLI 356
Cdd:NF038006 276 fDVFTRIsraEWDTLLFFYGVVMCVGGLGFLGYLGLVSE--TLYTGWNPVWANILL----GLLSSVVDNIPVMFAVLSMQ 349
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446467380 357 NDMAVGlglspsdaqidvLWWALALGACLGGNGTLIGASANVIVAGIASREGHKFSYMEFLKV 419
Cdd:NF038006 350 PEMSMG------------NWLLITLTAGVGGSLLSIGSAAGVALMGQARGIYTFFSHLKWAPV 400
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
15-205 |
3.38e-05 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 45.65 E-value: 3.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 15 FAIAVFLITYAIIISEKINRAVIALLGAALMVIVGVVDLHNAFtKHIEWGTITLLIGMMILVNITSKSGVFQYVAIKAAK 94
Cdd:cd01115 194 LIITIVLLAALAAITGLLPVSVAIAIGAIVLVFGGVLLTKEDY-KSIDWGIIFLFAGGIPLGKALESSGAAALIAEALIS 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446467380 95 GAQG-NPIKILISLSLLTALGSAFLDNVTTVLLVVPVTLSITRILQVNPVPYLLSeIIFSNIGGTATLIGDPPNIMIGSA 173
Cdd:cd01115 273 LLGGlPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLA-VAIGASCAFMLPVGTPPNAIVLGP 351
|
170 180 190
....*....|....*....|....*....|..
gi 446467380 174 NKhLDFNAFLLNLAPIVIIIIGVTATILYFMY 205
Cdd:cd01115 352 GG-YKFSDFAKVGLPLSILSLVVSVTMIPLIW 382
|
|
| |
