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Conserved domains on  [gi|446470179|ref|WP_000548033|]
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MULTISPECIES: GntR family transcriptional regulator [Bacillus]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448193)

GntR family transcriptional regulator simlar to MngR, which is involved in the regulation of mannosyl-glycerate transport and metabolism

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0003700
PubMed:  33509775|26172911|2060763

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
3-116 2.15e-47

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


:

Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 148.79  E-value: 2.15e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446470179   3 IQLDPRSNTPIWEQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVSQSITP 82
Cdd:COG1725    1 IRIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARE 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446470179  83 TLDERKIAMVEKQFHQLLLEASYLGVTKDKIHDW 116
Cdd:COG1725   81 LLEERREEFLEEALRELVAEARRLGLSLEELLEL 114
 
Name Accession Description Interval E-value
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
3-116 2.15e-47

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 148.79  E-value: 2.15e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446470179   3 IQLDPRSNTPIWEQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVSQSITP 82
Cdd:COG1725    1 IRIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARE 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446470179  83 TLDERKIAMVEKQFHQLLLEASYLGVTKDKIHDW 116
Cdd:COG1725   81 LLEERREEFLEEALRELVAEARRLGLSLEELLEL 114
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 12-77 4.97e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 85.19  E-value: 4.97e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446470179  12 PIWEQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVS 77
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
17-76 9.81e-17

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 69.14  E-value: 9.81e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446470179    17 IVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFV 76
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 15-76 1.05e-15

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 66.48  E-value: 1.05e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446470179   15 EQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFV 76
Cdd:pfam00392   3 EQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 15-83 1.26e-13

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 66.22  E-value: 1.26e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446470179  15 EQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVSQSITPT 83
Cdd:PRK15481   8 NEIFDSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGSPSPV 76
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 7-76 2.83e-07

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 47.86  E-value: 2.83e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446470179    7 PRSNTPIWEQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFV 76
Cdd:TIGR02325   3 RTSGVALWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFV 72
 
Name Accession Description Interval E-value
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
3-116 2.15e-47

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 148.79  E-value: 2.15e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446470179   3 IQLDPRSNTPIWEQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVSQSITP 82
Cdd:COG1725    1 IRIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARE 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446470179  83 TLDERKIAMVEKQFHQLLLEASYLGVTKDKIHDW 116
Cdd:COG1725   81 LLEERREEFLEEALRELVAEARRLGLSLEELLEL 114
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-86 2.06e-28

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 107.99  E-value: 2.06e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446470179   1 MHIQLDPRSNTPIWEQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVSQSI 80
Cdd:COG1167    1 MLIRLDRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARL 80


                 ....*.
gi 446470179  81 TPTLDE 86
Cdd:COG1167   81 PAPAPA 86
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 12-77 4.97e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 85.19  E-value: 4.97e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446470179  12 PIWEQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVS 77
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
8-78 7.83e-18

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 76.44  E-value: 7.83e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446470179   8 RSNTPIWEQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVSQ 78
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAE 71
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
17-76 9.81e-17

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 69.14  E-value: 9.81e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446470179    17 IVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFV 76
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 15-76 1.05e-15

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 66.48  E-value: 1.05e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446470179   15 EQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFV 76
Cdd:pfam00392   3 EQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 15-83 1.26e-13

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 66.22  E-value: 1.26e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446470179  15 EQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVSQSITPT 83
Cdd:PRK15481   8 NEIFDSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGSPSPV 76
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
7-77 3.99e-13

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 63.80  E-value: 3.99e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446470179   7 PRSNTPIWEQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVS 77
Cdd:COG2186    2 PIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVR 72
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 15-91 1.14e-10

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 57.08  E-value: 1.14e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446470179  15 EQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVsQSITPTLDERKIAM 91
Cdd:PRK10421   5 DEVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI-RWRHETWSEQNIVQ 80
PRK14999 PRK14999
histidine utilization repressor; Provisional
 1-78 2.42e-07

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 48.01  E-value: 2.42e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446470179   1 MHIQLDPRSNTPIWEQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVSQ 78
Cdd:PRK14999   1 MYSSRSRSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAE 78
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 7-76 2.83e-07

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 47.86  E-value: 2.83e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446470179    7 PRSNTPIWEQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFV 76
Cdd:TIGR02325   3 RTSGVALWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFV 72
PRK11402 PRK11402
transcriptional regulator PhoB;
5-76 1.02e-06

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 45.98  E-value: 1.02e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446470179   5 LDPRSNTPIWEQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFV 76
Cdd:PRK11402   2 TDRYSHQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFV 73
PRK10225 PRK10225
Uxu operon transcriptional regulator;
6-82 1.57e-06

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 45.78  E-value: 1.57e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446470179   6 DPRSNTPIWEQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVSQSITP 82
Cdd:PRK10225   3 SATSAQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGS 79
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
17-103 2.15e-06

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 45.40  E-value: 2.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446470179  17 IVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVS----QSITPTLDERKIAMV 92
Cdd:PRK09464  15 IEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQsslwQSFSDPLVELLSDHP 94

                         90
                 ....*....|.
gi 446470179  93 EKQFHqlLLEA 103
Cdd:PRK09464  95 ESQFD--LLET 103
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
6-86 5.18e-06

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 44.14  E-value: 5.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446470179   6 DPRSNTPIWEQIVQNIKELVLKNMLAPSDKLpSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVSQsitPTLD 85
Cdd:COG1802    5 SPLRRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP---LSPE 80


                 .
gi 446470179  86 E 86
Cdd:COG1802   81 E 81
PRK09764 PRK09764
GntR family transcriptional regulator;
9-78 1.46e-05

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 42.89  E-value: 1.46e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446470179   9 SNTPIWEQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVSQ 78
Cdd:PRK09764   2 GHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKE 71
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 13-76 2.73e-05

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 41.97  E-value: 2.73e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446470179   13 IWEQIVQNIKELVLKnmlaPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFV 76
Cdd:TIGR02404   5 IYQDLEQKITKGQYK----EGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIV 64
Rrf2 pfam02082
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
 30-73 4.41e-05

Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 396591 [Multi-domain]  Cd Length: 131  Bit Score: 40.61  E-value: 4.41e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 446470179   30 LAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKG 73
Cdd:pfam02082  17 LHPGGEPVTSEEIAERQNISPVYLEKILAKLRKAGLVESVRGAG 60
IscR COG1959
DNA-binding transcriptional regulator, IscR family [Transcription];
30-73 6.86e-05

DNA-binding transcriptional regulator, IscR family [Transcription];


Pssm-ID: 441562  Cd Length: 141  Bit Score: 40.21  E-value: 6.86e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 446470179  30 LAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKG 73
Cdd:COG1959   18 LHPGGEPVTSKEIAERQGISPSYLEKILQKLRKAGLVESVRGPG 61
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 12-78 6.88e-05

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 40.91  E-value: 6.88e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446470179  12 PIWEQIVQNIKELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVSQ 78
Cdd:PRK09990   7 PIADVVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVAR 73
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 39-115 5.06e-04

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 36.81  E-value: 5.06e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446470179    39 VRELASLLVINPNTVSKAYQELERQGIIETLRGKGtfvsqsITPTLDERKIAMVEKQFHQLL--LEASYLGVTKDKIHD 115
Cdd:smart00529   1 TSEIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRG------ITLTEKGRRLARRLLRKHRLLerFLVDVLGVDEEEVHE 73
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 11-73 6.04e-04

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 37.97  E-value: 6.04e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446470179  11 TPIWEQIVQNIKELVLKNMLAPSdklpsVRELASLLVINPNTVSKAYQELERQGIIETLRGKG 73
Cdd:COG1974    5 TKRQREILDFIKEYIRERGYPPS-----QREIAEALGLSSSAVHRHLKALEKKGYLRRDPGKS 62
HTH_36 pfam13730
Helix-turn-helix domain;
37-66 2.52e-03

Helix-turn-helix domain;


Pssm-ID: 463970 [Multi-domain]  Cd Length: 55  Bit Score: 34.00  E-value: 2.52e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 446470179   37 PSVRELASLLVINPNTVSKAYQELERQGII 66
Cdd:pfam13730  26 PSVETLAKRLGLSRRTIQRAIKELEELGYL 55
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
33-115 2.84e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 35.56  E-value: 2.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446470179  33 SDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGtfvsqsITPTLDERKIA--MVEKqfHQLLLE--ASYLGV 108
Cdd:COG1321   21 EGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGG------ITLTEEGRELAlrIVRR--HRLLERflVEVLGV 92


                 ....*..
gi 446470179 109 TKDKIHD 115
Cdd:COG1321   93 DWDEAHE 99
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 1-76 3.57e-03

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 35.91  E-value: 3.57e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446470179   1 MHIQLDPRSNTPIWEQIVQNIkELVLKNMLAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFV 76
Cdd:PRK10079   1 MHLSRHPTSYPTRYQEIAAKL-EQELRQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLV 75
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 26-85 5.93e-03

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 35.38  E-value: 5.93e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446470179  26 LKNM-----LAPSDKLPSVRELASLLVINPNTVSKAYQELERQGIIETLRGKGTFVSQsitPTLD 85
Cdd:PRK03837  22 LEQMirsgeFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSR---PSAD 83
HTH_Crp_2 pfam13545
Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain ...
 38-68 9.45e-03

Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.


Pssm-ID: 463917 [Multi-domain]  Cd Length: 68  Bit Score: 32.81  E-value: 9.45e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 446470179   38 SVRELASLLVINPNTVSKAYQELERQGIIET 68
Cdd:pfam13545  24 TQEDLADLLGTTRETVSRVLSELRREGLIER 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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